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13 results on '"Ferrandes, Fabio"'

7. A Novel PSEN1 Variant Leading to Posterior Cortical Atrophy: A Case Report

Author

Roveta, Fausto, primary, Marcinnò, Andrea, additional, Grassini, Alberto, additional, Ferrandes, Fabio, additional, Cermelli, Aurora, additional, Boschi, Silvia, additional, Gallone, Salvatore, additional, Atzori, Cristiana, additional, Imperiale, Daniele, additional, Dentelli, Patrizia, additional, Pasini, Barbara, additional, Brusco, Alfredo, additional, Rubino, Elisa, additional, and Rainero, Innocenzo, additional

Published
2023
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9. Polymorphisms of the Proinflammatory Cytokine Genes Modulate the Response to NSAIDs but Not to Triptans in Migraine Attacks

Author

Rubino, Elisa, primary, Marcinnò, Andrea, additional, Grassini, Alberto, additional, Piella, Elisa Maria, additional, Ferrandes, Fabio, additional, Roveta, Fausto, additional, Boschi, Silvia, additional, Cermelli, Aurora, additional, Gallone, Salvatore, additional, Savi, Lidia, additional, and Rainero, Innocenzo, additional

Published
2022
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12. Polymorphisms of the Proinflammatory Cytokine Genes Modulate the Response to NSAIDs but Not to Triptans in Migraine Attacks.

Author

Rubino, Elisa, Marcinnò, Andrea, Grassini, Alberto, Piella, Elisa Maria, Ferrandes, Fabio, Roveta, Fausto, Boschi, Silvia, Cermelli, Aurora, Gallone, Salvatore, Savi, Lidia, and Rainero, Innocenzo

Subjects
SUMATRIPTAN, MIGRAINE, MIGRAINE aura, NONSTEROIDAL anti-inflammatory agents, CYTOKINES, ANALGESIA, SPREADING cortical depression
Abstract

Migraine is a common neurovascular disorder characterized by recurrent episodes of headache and associated neurological symptoms. At present, a significant portion of patients do not obtain a satisfactory response to acute pain-relieving therapies, including NSAIDs and triptans. In this context, pharmacogenetics plays a key role in the understanding of such a diverse response. In order to investigate whether functional polymorphisms in proinflammatory cytokine genes (IL-1α, IL-1β, IL-1RN; IL-6 and TNF-α) may influence the response to acute treatment, 313 consecutive patients with episodic migraine without aura were enrolled. Pain relief by administration of NSAIDs or triptans for three consecutive migraine attacks was evaluated. We found a significant association between A allele of the TNF-α promoter (−308 A/G) and a lack of efficacy after NSAID administration (p < 0.01, OR 2.51, 95% CI: 1.33 < OR < 4.75 compared to the G allele). Remaining polymorphisms had no significant effect on pain relief. Our study showed that a functional polymorphism in the TNF-α gene significantly modulates the clinical response to NSAID administration in acute attacks. Patients with higher production of the active cytokine during stress showed a significantly lower anti-migraine effect. Our results further support a role for TNF-α in the pathophysiological mechanisms of migraine attack. [ABSTRACT FROM AUTHOR]

Published
2023
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13. Short-latency afferent inhibition and somato-sensory evoked potentials during the migraine cycle: surrogate markers of a cycling cholinergic thalamo-cortical drive?

Author

Coppola, Gianluca, primary, Lenola, Davide Di, additional, Abagnale, Chiara, additional, Ferrandes, Fabio, additional, Sebastianelli, Gabriele, additional, Casillo, Francesco, additional, Lorenzo, Cherubino Di, additional, Serrao, Mariano, additional, Evangelista, Maurizio, additional, Schoenen, Jean, additional, and Pierelli, Francesco, additional

Published
2020
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