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1. Global prevalence, cascade of care, and prophylaxis coverage of hepatitis B in 2022: a modelling study

Author

Razavi-Shearer, Devin, Gamkrelidze, Ivane, Pan, Calvin, Jia, Jidong, Berg, Thomas, Gray, Richard, Lim, Young-Suk, Chen, Chien-Jen, Ocama, Ponsiano, Desalegn, Hailemichael, Abbas, Zaigham, Abdallah, Ayat, Aghemo, Alessio, Ahmadbekova, Sabohat, Ahn, Sang Hoon, Aho, Inka, Akarca, Ulus, Al Masri, Nasser, Alalwan, Abduljaleel, Alavian, Seyed, Al-Busafi, Said, Aleman, Soo, Alfaleh, Faleh, Alghamdi, Abdullah, Al-Hamoudi, Waleed, Aljumah, Abdulrahman, Al-Naamani, Khalid, Al-Rifai, Ahmad, Alserkal, Yousif, Altraif, Ibrahim, Amarsanaa, Jazag, Anderson, Motswedi, Andersson, Monique, Armstrong, Paige, Asselah, Tarik, Athanasakis, Kostas, Baatarkhuu, Oidov, Ben-Ari, Ziv, Bensalem, Aicha, Bessone, Fernando, Biondi, Mia, Bizri, Abdul Rahman, Blach, Sarah, Braga, Wornei, Brandão-Mello, Carlos, Brosgart, Carol, Brown, Kimberly, Brown, Jr, Robert, Bruggmann, Philip, Brunetto, Maurizia, Buti, Maria, Cabezas, Joaquin, Casanovas, Teresa, Chae, Chungman, Chan, Henry Lik Yuen, Cheinquer, Hugo, Chen, Pei-Jer, Cheng, Kent Jason, Cheon, Myeong-Eun, Chien, Cheng-Hung, Choudhuri, Gourdas, Christensen, Peer Brehm, Chuang, Wan-Long, Chulanov, Vladimir, Cisneros, Laura, Coffin, Carla, Contreras, Fernando, Coppola, Nicola, Cornberg, Markus, Cowie, Benjamin, Cramp, Matthew, Craxi, Antonio, Crespo, Javier, Cui, Fuqiang, Cunningham, Chris, Dalgard, Olav, De Knegt, Robert, De Ledinghen, Victor, Dore, Gregory, Drazilova, Sylvia, Duberg, Ann-Sofi, Egeonu, Steve, Elbadri, Mohammed, El-Kassas, Mohamed, El-Sayed, Manal, Estes, Chris, Etzion, Ohad, Farag, Elmobashar, Ferradini, Laurent, Ferreira, Paulo, Flisiak, Robert, Forns, Xavier, Frankova, Sona, Fung, James, Gane, Edward, Garcia, Virginia, García-Samaniego, Javier, Gemilyan, Manik, Genov, Jordan, Gheorghe, Liliana, Gholam, Pierre, Gish, Robert, Goleij, Pouya, Gottfredsson, Magnus, Grebely, Jason, Gschwantler, Michael, Guingane, Nanelin Alice, Hajarizadeh, Behzad, Hamid, Saeed, Hamoudi, Waseem, Harris, Aaron, Hasan, Irsan, Hatzakis, Angelos, Hellard, Margaret, Hercun, Julian, Hernandez, Javier, Hockicková, Ivana, Hsu, Yao-Chun, Hu, Ching-Chih, Husa, Petr, Janicko, Martin, Janjua, Naveed, Jarcuska, Peter, Jaroszewicz, Jerzy, Jelev, Deian, Jeruma, Agita, Johannessen, Asgeir, Kåberg, Martin, Kaita, Kelly, Kaliaskarova, Kulpash, Kao, Jia-Horng, Kelly-Hanku, Angela, Khamis, Faryal, Khan, Aamir, Kheir, Omer, Khoudri, Ibtissam, Kondili, Loreta, Konysbekova, Aliya, Kristian, Pavol, Kwon, Jisoo, Lagging, Martin, Laleman, Wim, Lampertico, Pietro, Lavanchy, Daniel, Lázaro, Pablo, Lazarus, Jeffrey V, Lee, Alice, Lee, Mei-Hsuan, Liakina, Valentina, Lukšić, Boris, Malekzadeh, Reza, Malu, Abraham, Marinho, Rui, Mendes-Correa, Maria Cássia, Merat, Shahin, Meshesha, Berhane Redae, Midgard, Håvard, Mohamed, Rosmawati, Mokhbat, Jacques, Mooneyhan, Ellen, Moreno, Christophe, Mortgat, Laure, Müllhaupt, Beat, Musabaev, Erkin, Muyldermans, Gaëtan, Naveira, Marcelo, Negro, Francesco, Nersesov, Alexander, Nguyen, Van Thi Thuy, Ning, Qing, Njouom, Richard, Ntagirabiri, Rénovat, Nurmatov, Zuridin, Oguche, Stephen, Omuemu, Casimir, Ong, Janus, Opare-Sem, Ohene, Örmeci, Necati, Orrego, Mauricio, Osiowy, Carla, Papatheodoridis, George, Peck-Radosavljevic, Markus, Pessoa, Mário, Pham, Trang, Phillips, Richard, Pimenov, Nikolay, Pincay-Rodríguez, Loreley, Plaseska-Karanfilska, Dijana, Pop, Cora, Poustchi, Hossein, Prabdial-Sing, Nishi, Qureshi, Huma, Ramji, Alnoor, Rautiainen, Henna, Razavi-Shearer, Kathryn, Remak, William, Ribeiro, Sofia, Ridruejo, Ezequiel, Ríos-Hincapié, Cielo, Robalino, Marcia, Roberts, Lewis, Roberts, Stuart, Rodríguez, Manuel, Roulot, Dominique, Rwegasha, John, Ryder, Stephen, Sadirova, Shakhlo, Saeed, Umar, Safadi, Rifaat, Sagalova, Olga, Said, Sanaa, Salupere, Riina, Sanai, Faisal, Sanchez-Avila, Juan F, Saraswat, Vivek, Sargsyants, Narina, Sarrazin, Christoph, Sarybayeva, Gulya, Schréter, Ivan, Seguin-Devaux, Carole, Seto, Wai-Kay, Shah, Samir, Sharara, Ala, Sheikh, Mahdi, Shouval, Daniel, Sievert, William, Simojoki, Kaarlo, Simonova, Marieta, Sinn, Dong Hyun, Sonderup, Mark, Sonneveld, Milan, Spearman, C Wendy, Sperl, Jan, Stauber, Rudolf, Stedman, Catherine, Sypsa, Vana, Tacke, Frank, Tan, Soek-Siam, Tanaka, Junko, Tergast, Tammo, Terrault, Norah, Thompson, Alexander, Thompson, Peyton, Tolmane, Ieva, Tomasiewicz, Krzysztof, Tsang, Tak-Yin, Uzochukwu, Benjamin, Van Welzen, Berend, Vanwolleghem, Thomas, Vince, Adriana, Voeller, Alexis, Waheed, Yasir, Waked, Imam, Wallace, Jack, Wang, Cong, Weis, Nina, Wong, Grace, Wong, Vincent, Wu, Jaw-Ching, Yaghi, Cesar, Yesmembetov, Kakharman, Yip, Terry, Yosry, Ayman, Yu, Ming-Lung, Yuen, Man-Fung, Yurdaydin, Cihan, Zeuzem, Stefan, Zuckerman, Eli, and Razavi, Homie

Published
2023
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2. Supervised versus unsupervised antimalarial treatment with six-dose artemether-lumefantrine: pharmacokinetic and dosage-related findings from a clinical trial in Uganda

Author

Ruzagira Eugene, Grandesso Francesco, Biraro Samuel, Bajunirwe Francis, Fogg Carole, Piola Patrice, Checchi Francesco, Babigumira Joseph, Kigozi Isaac, Kiguli James, Kyomuhendo Juliet, Ferradini Laurent, Taylor Walter RJ, and Guthmann Jean-Paul

Subjects
Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background A six-dose antimalarial regimen of artemether-lumefantrine (A/L) may soon become one of the most widely used drug combination in Africa, despite possible constraints with adherence and poor absorption due to inadequate nutrition, and a lack of pharmacokinetic and effectiveness data. Methods Within a trial of supervised versus unsupervised A/L treatment in a stable Ugandan Plasmodium falciparum transmission setting, plasma lumefantrine concentrations were measured in a subset of patients on day 3 (C [lum]day3) and day 7 (C [lum]day7) post-inclusion. Predictors of lumefantrine concentrations were analysed to show how both C [lum]day7 and the weight-adjusted lumefantrine dose affect 28-day recrudescence and re-infection risks. The implications of these novel findings are discussed in terms of the emergence of lumefantrine-resistant strains in Africa. Results C [lum]day3 and C [lum]day7 distributions among 241 supervised and 238 unsupervised patients were positively skewed. Unsupervised treatment and decreasing weight-adjusted lumefantrine dose were negatively associated with C [lum]day3. Unsupervised treatment and decreasing age showed strong negative associations with C [lum]day7. Both models were poorly predictive (R-squared < 0.25). There were no recrudescences in either arm, but decreasing lumefantrine dose per Kg resulted in up to 13-fold higher adjusted risks of re-infection. Re-infections occurred only among patients with C [lum]day7 below 400 ng/mL (p < 0.001). Conclusion Maintaining the present six-dose regimen and ensuring high adherence and intake are essential to maximize the public health benefits of this valuable drug combination.

Published
2006
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3. Global change in hepatitis C virus prevalence and cascade of care between 2015 and 2020: a modelling study

Author

Blach, Sarah, Terrault, Norah A, Tacke, Frank, Gamkrelidze, Ivane, Craxi, Antonio, Tanaka, Junko, Waked, Imam, Dore, Gregory J, Abbas, Zaigham, Abdallah, Ayat R, Abdulla, Maheeba, Aghemo, Alessio, Aho, Inka, Akarca, Ulus S, Alalwan, Abduljaleel M, Alanko Blomé, Marianne, Al-Busafi, Said A, Aleman, Soo, Alghamdi, Abdullah S, Al-Hamoudi, Waleed K, Aljumah, Abdulrahman A, Al-Naamani, Khalid, Al Serkal, Yousif M, Altraif, Ibrahim H, Anand, Anil C, Anderson, Motswedi, Andersson, Monique I, Athanasakis, Kostas, Baatarkhuu, Oidov, Bakieva, Shokhista R, Ben-Ari, Ziv, Bessone, Fernando, Biondi, Mia J, Bizri, Abdul Rahman N, Brandão-Mello, Carlos E, Brigida, Krestina, Brown, Kimberly A, Brown, Jr, Robert S, Bruggmann, Philip, Brunetto, Maurizia R, Busschots, Dana, Buti, Maria, Butsashvili, Maia, Cabezas, Joaquin, Chae, Chungman, Chaloska Ivanova, Viktorija, Chan, Henry Lik Yuen, Cheinquer, Hugo, Cheng, Kent Jason, Cheon, Myeong-Eun, Chien, Cheng-Hung, Chien, Rong-Nan, Choudhuri, Gourdas, Christensen, Peer Brehm, Chuang, Wan-Long, Chulanov, Vladimir, Cisneros, Laura E, Coco, Barbara, Contreras, Fernando A, Cornberg, Markus, Cramp, Matthew E, Crespo, Javier, Cui, Fuqiang, Cunningham, Chris W, Dagher Abou, Lucy, Dalgard, Olav, Dao, Doan Y, De Ledinghen, Victor, Derbala, Moutaz F, Deuba, Keshab, Dhindsa, Karan, Djauzi, Samsuridjal, Drazilova, Sylvia, Duberg, Ann-Sofi, Elbadri, Mohammed, El-Sayed, Manal H, Esmat, Gamal, Estes, Chris, Ezzat, Sameera, Färkkilä, Martti A, Ferradini, Laurent, Ferraz, Maria Lucia G, Ferreira, Paulo R A, Filipec Kanizaj, Tajana, Flisiak, Robert, Frankova, Sona, Fung, James, Gamkrelidze, Amiran, Gane, Edward, Garcia, Virginia, García-Samaniego, Javier, Gemilyan, Manik, Genov, Jordan, Gheorghe, Liliana S, Gholam, Pierre M, Goldis, Adrian, Gottfredsson, Magnus, Gray, Richard T, Grebely, Jason, Gschwantler, Michael, Hajarizadeh, Behzad, Hamid, Saeed S, Hamoudi, Waseem, Hatzakis, Angelos, Hellard, Margaret E, Himatt, Sayed, Hofer, Harald, Hrstic, Irena, Hunyady, Bela, Husa, Petr, Husic-Selimovic, Azra, Jafri, Wasim S M, Janicko, Martin, Janjua, Naveed, Jarcuska, Peter, Jaroszewicz, Jerzy, Jerkeman, Anna, Jeruma, Agita, Jia, Jidong, Jonasson, Jon G, Kåberg, Martin, Kaita, Kelly D E, Kaliaskarova, Kulpash S, Kao, Jia-Horng, Kasymov, Omor T, Kelly-Hanku, Angela, Khamis, Faryal, Khamis, Jawad, Khan, Aamir G, Khandu, Lekey, Khoudri, Ibtissam, Kielland, Knut B, Kim, Do Young, Kodjoh, Nicolas, Kondili, Loreta A, Krajden, Mel, Krarup, Henrik Bygum, Kristian, Pavol, Kwon, Jisoo A, Lagging, Martin, Laleman, Wim, Lao, Wai Cheung, Lavanchy, Daniel, Lázaro, Pablo, Lazarus, Jeffrey V, Lee, Alice U, Lee, Mei-Hsuan, Li, Michael K K, Liakina, Valentina, Lim, Young-Suk, Löve, Arthur, Lukšić, Boris, Machekera, Shepherd Mufudzi, Malu, Abraham O, Marinho, Rui T, Maticic, Mojca, Mekonnen, Hailemichael D, Mendes-Correa, Maria Cássia, Mendez-Sanchez, Nahum, Merat, Shahin, Meshesha, Berhane Redae, Midgard, Håvard, Mills, Mike, Mohamed, Rosmawati, Mooneyhan, Ellen, Moreno, Christophe, Muljono, David H, Müllhaupt, Beat, Musabaev, Erkin, Muyldermans, Gaëtan, Nartey, Yvonne Ayerki, Naveira, Marcelo C M, Negro, Francesco, Nersesov, Alexander V, Njouom, Richard, Ntagirabiri, Rénovat, Nurmatov, Zuridin S, Obekpa, Solomon A, Oguche, Stephen, Olafsson, Sigurdur, Ong, Janus P, Opare-Sem, Ohene K, Orrego, Mauricio, Øvrehus, Anne L, Pan, Calvin Q, Papatheodoridis, George V, Peck-Radosavljevic, Markus, Pessoa, Mário G, Phillips, Richard O, Pimenov, Nikolay, Plaseska-Karanfilska, Dijana, Prabdial-Sing, Nishi N, Puri, Pankaj, Qureshi, Huma, Rahman, Aninda, Ramji, Alnoor, Razavi-Shearer, Devin M, Razavi-Shearer, Kathryn, Ridruejo, Ezequiel, Ríos-Hincapié, Cielo Y, Rizvi, S M Shahriar, Robaeys, Geert K M M, Roberts, Lewis R, Roberts, Stuart K, Ryder, Stephen D, Sadirova, Shakhlo, Saeed, Umar, Safadi, Rifaat, Sagalova, Olga, Said, Sanaa S, Salupere, Riina, Sanai, Faisal M, Sanchez-Avila, Juan F, Saraswat, Vivek A, Sarrazin, Christoph, Sarybayeva, Gulya, Seguin-Devaux, Carole, Sharara, Ala I, Sheikh, Mahdi, Shewaye, Abate B, Sievert, William, Simojoki, Kaarlo, Simonova, Marieta Y, Sonderup, Mark W, Spearman, C Wendy, Sperl, Jan, Stauber, Rudolf E, Stedman, Catherine A M, Su, Tung-Hung, Suleiman, Anita, Sypsa, Vana, Tamayo Antabak, Natalia, Tan, Soek-Siam, Tergast, Tammo L, Thurairajah, Prem H, Tolmane, Ieva, Tomasiewicz, Krzysztof, Tsereteli, Maia, Uzochukwu, Benjamin S C, Van De Vijver, David A M C, Van Santen, Daniela K, Van Vlierberghe, Hans, Van Welzen, Berend, Vanwolleghem, Thomas, Vélez-Möller, Patricia, Villamil, Federico, Vince, Adriana, Waheed, Yasir, Weis, Nina, Wong, Vincent W-S, Yaghi, Cesar G, Yesmembetov, Kakharman, Yosry, Ayman, Yuen, Man-Fung, Yunihastuti, Evy, Zeuzem, Stefan, Zuckerman, Eli, and Razavi, Homie A

Published
2022
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5. Massive Iatrogenic Outbreak of Human Immunodeficiency Virus Type 1 in Rural Cambodia, 2014–2015

Author

Rouet, François, Nouhin, Janin, Zheng, Du-Ping, Roche, Benjamin, Black, Allison, Prak, Sophearot, Leoz, Marie, Gaudy-Graffin, Catherine, Ferradini, Laurent, Mom, Chandara, Mam, Sovatha, Gautier, Charlotte, Lesage, Gérard, Ken, Sreymom, Phon, Kerya, Kerleguer, Alexandra, Yang, Chunfu, Killam, William, Fujita, Masami, Mean, Chhivun, Fontenille, Didier, Barin, Francis, Plantier, Jean-Christophe, Bedford, Trevor, Ramos, Artur, and Saphonn, Vonthanak

Published
2018

6. Access to prevention of mother-to-child transmission of HIV along HIV services cascade through integrated active case management in 15 operational districts in Cambodia

Author

Samreth, Sovannarith, Keo, Vannak, Tep, Romaing, Ke, Angheng, Ouk, Vichea, Ngauv, Bora, Mam, Sovatha, Ferradini, Laurent, Ly, Penh S., Mean, Chhi V., and Delvaux, Therese

Subjects
Infants -- Analysis, Highly active antiretroviral therapy -- Analysis, HIV tests -- Usage -- Analysis, HIV -- Prevention -- Analysis, Sexually transmitted disease prevention -- Usage -- Analysis, Pregnant women -- Analysis, Company business management, Health, World Health Organization -- Management
Abstract

Introduction: Following the introduction of option B+ in 2013, and with the perspective of eliminating mother-to-child transmission of HIV by 2025, Cambodia has implemented an integrated active case management (IACM) approach since 2014 to improve the notification and follow-up of all HIV-infected cases including pregnant women, and to ensure access to and use of the full prevention of mother-to-child transmission (PMTCT) service package by HIV-infected pregnant women and their HIVexposed infants. This study aimed to analyse PMTCT cascade data in 15 operational districts (ODs) implementing the IACM approach in Cambodia. Methods: We analysed PMTCT cohort data from 15 ODs implementing IACM approach between 1 January 2014 and 31 December 2016. We measured key indicators along the PMTCT cascade and compared them to available (cross-sectional) PMTCT indicators during the 2011 to 2013 period. Results: During the period 2014 to 2016, among 938 identified HIV-infected pregnant women, 308 (32.8%) were tested HIV positive during their pregnancy, 9 (1.0%) during labour, while the remaining 621 (66.2%) were women on antiretroviral therapy (ART) who became pregnant. During the study period, 867 (92.4%) of the 938 women received ART during pregnancy and abour. Subsequently, 456 (85.6%) of the 533 HEI born and alive during the study period received 6-week antiretroviral (ARV) prophylaxis, 390 (76.6%) and 396 (77.8%) of the 509 infants aged six weeks or older received cotrimoxazole prophylaxis and HIV-DNA PCR test respectively. Among the 396 HEI who received HIV-DNA PCR test, 7 (1.8%) were found HIV positive. The comparison with cross-sectional PMTCT indicator obtained during the previous 2011 to 2013 period in the same 15 ODs, showed a significant increase in ARV uptake among HIV-infected pregnant women (from 72.3% to 92.4%), in cotrimoxazole uptake (from 41.6% to 73.2%), and in HIV-DNA PCR testing coverage among HEI (from 41.2% to 74.3%). Conclusions: The implementation of option B+ and IACM may have contributed to the improvement of the PMTCT cascade in Cambodia. However, some gaps in accessing PMTCT services along the HIV cascade persist and need to be addressed. Keywords: ARV; children; HIV prevention; vertical transmission; pediatric; ART; maternal; mother-to-child transmission; PMTCT, 1 | INTRODUCTION Elimination of paediatric HIV infections and ensuring survival and long-term wellbeing of HIV-infected women are of high international public health concern [1-4]. Cambodia has made large progress [...]

Published
2019
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10. High efficacy of lopinavir/r-based second-line antiretroviral treatment after 24 months of follow up at ESTHER/Calmette Hospital in Phnom Penh, Cambodia

Author

Ferradini, Laurent, Ouk, Vara, Segeral, Olivier, Nouhin, Janin, Dulioust, Anne, Hak, Chanroeurn, Fournier, Isabelle, Lerolle, Nathalie, Ngin, Sopheak, Mean, Chhi Vun, Delfraissy, Jean?François, and Nerrienet, Eric

Subjects
Lopinavir -- Dosage and administration -- Patient outcomes, Highly active antiretroviral therapy -- Dosage and administration -- Patient outcomes, HIV infection -- Care and treatment, Health
Abstract

Background: The number of patients on second‐line highly active antiretroviral therapy (HAART) regimens is increasing in resource‐limited settings. We describe the outcomes after 24 months for patients on LPV/r‐based second‐line regimens followed up by the ESTHER programme in Phnom Penh, Cambodia. Methods: Seventy patients who initiated second‐line HAART regimens more than 24 months earlier were included, and immuno‐virological data analyzed. HIV RNA viral load was determined by real‐time RT‐PCR. HIV‐1 drug resistance was interpreted according to the ANRS algorithm. Results: Of the 70 patients, two were lost to follow up, three died and 65 (92.8%) remained on second‐line treatment after 24 months of follow up (median duration of treatment: 27.4 months). At switch to second‐line, the median CD4 T cell count was 106 cells/mm[sup.3] and the median viral load was 4.7 Log[sub.10]. Second‐line regimens prescribed were ddI/3TC/LPV[sub./r] (65.7%), ddI/TDF/LPV[sub./r] (10.0%), ddI/AZT/LPV[sub./r] (8.6%) and TDF/3TC/LPV[sub./r] (7.1%). The median CD4 T cell gain was +258 cells/mm[sup.3] at 24 months (n = 63). After 24 months of follow up, 92.3% (60/65) of the patients presented undetectable viral loads, giving an overall treatment success rate of 85.7% (CI: 75.6‐ 92.0) in intent‐to‐treat analysis. Conclusions: These data suggest that a LPV[sub./r]‐based second‐line regimen is associated with a high rate of virological suppression and immune reconstitution after 24 months of follow up in Cambodia., Background Highly active antiretroviral therapy (HAART) programmes have proven the feasibility and efficacy of first‐line HAART regimens in resource‐limited settings, similar to those reported in developed countries [1‐10]. As initially [...]

Published
2011
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11. Prevalence, determinants of positivity, and clinical utility of cryptococcal antigenemia in Cambodian HIV-infected patients

Author

Micol, Romain, Sar, Borann, Laureillard, Didier, Ngeth, ChanChhaya, Lortholary, Olivier, Dousset, Jean-Philippe, Chanroeun, Hak, Ferradini, Laurent, Jean Guerin, Philippe, Dromer, Francoise, and Fontanet, Arnaud

Subjects
Cambodia -- Health aspects, HIV infection -- Diagnosis, HIV infection -- Risk factors, Cryptococcal infections -- Risk factors, Health
Abstract

The prevalence, determinants of positivity, and clinical utility of serum cryptococcal polysaccharide (CPS) antigen testing determined among HIV-infected patients in 2004 in Cambodia reveal that AIDS patients with a CD[4.sup.+] count less than 100 cells/m[m.sup.3] could be useful in areas highly endemic for cryptococcosis for early diagnosis and treatment of such infection.

Published
2007

12. Impact of HIV-1 genetic diversity on plasma HIV-1 RNA quantification: Usefulness of the Agence Nationale de Recherches sur le SIDA second-generation long terminal repeat-based real-time reverse transcriptase polymerase chain reaction test

Author

Rouet, Francois, Chaix, Marie-Laure, Nerrienet, Eric, Nicole Ngo-Giang-Huong, Plantier, Jean-Christophe, Burgard, Marianne, Peters, Martine, Damond, Florence, Ekouevi, Didier Koumavi, Msellati, Philippe, Ferradini, Laurent, Rukobo, Sandra, Marechal, Valerie, Schvachsa, Nilda, Wakrim, Lahsen, Rafalimanana, Christian, Rakotoambinina, Benjamin, Seigneurin, Jean-Marie, Rouzioux, Christine, and Viard, Jean-Paul

Subjects
HIV infection -- Diagnosis, Blood plasma -- Analysis, Polymerase chain reaction, Health
Abstract

Plasma samples from patients infected with HIV-1 is studied with a second generation (G2), long terminal repeat (LTR) - based real-time reverse transcriptase polymerase chain reaction (RT-PCR) test developed at Necker Hospital, France and its usefulness is compared with commercially available assays. The G2 RT-PCR test is found to be a cost-effective and flexible alternative option to commercial assays.

Published
2007

14. The continuing HIV epidemic among men who have sex with men and transgender women in the ASEAN region: implications for HIV policy and service programming

Author

van Griensven, Frits, primary, de Lind van Wijngaarden, Jan Willem, additional, Eustaquio, Patrick Castillo, additional, Wignall, Stephen, additional, Azwa, Iskandar, additional, Veronese, Vanessa, additional, Ferradini, Laurent, additional, Phanuphak, Nittaya, additional, and Mills, Stephen, additional

Published
2021
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15. Supervised versus unsupervised intake of six-dose artemether-lumefantrine for treatment of acute, uncomplicated Plasmodium falciparum malaria in Mbarara, Uganda: a randomised trial

Author

Piola, Patrice, Fogg, Carole, Bajunirwe, Francis, Biraro, Samuel, Grandesso, Francesco, Ruzagira, Eugene, Babigumira, Joseph, Kigozi, Isaac, Kiguli, James, Kyomuhendo, Juliet, Ferradini, Laurent, Taylor, Walter, Checchi, Francesco, and Guthmann, Jean-Paul

Subjects
Chloroquine -- Dosage and administration, Malaria -- Care and treatment, Malaria -- Drug therapy, Malaria -- Patient outcomes, Uganda -- Health aspects
Published
2005

26. Integrated approach for triple elimination of mother-to-child transmission of HIV, hepatitis B and syphilis is highly effective and cost-effective: an economic evaluation

Author

Zhang, Lei, primary, Tao, Yusha, additional, Woodring, Joseph, additional, Rattana, Kim, additional, Sovannarith, Samreth, additional, Rathavy, Tung, additional, Cheang, Kannitha, additional, Hossain, Shafiqul, additional, Ferradini, Laurent, additional, Deng, Serongkea, additional, Sokun, Chay, additional, Samnang, Chham, additional, Nagai, Mari, additional, Lo, Ying-Ru, additional, and Ishikawa, Naoko, additional

Published
2019
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27. Corrigendum

Author

Vun, Mean Chhi, Fujita, Masami, Rathavy, Tung, Eang, Mao Tang, Sopheap, Seng, Sovannarith, Samreth, Chhorvann, Chhea, Vanthy, Ly, Sopheap, Oum, Welle, Emily, Ferradini, Laurent, Sedtha, Chin, Bunna, Sok, and Verbruggen, Robert

Subjects
Health
Abstract

Introduction: In the mid‐1990s, Cambodia faced one of the fastest growing HIV epidemics in Asia. For its achievement in reversing this trend, and achieving universal access to HIV treatment, the country received a United Nations millennium development goal award in 2010. This article reviews Cambodia’s response to HIV over the past two decades and discusses its current efforts towards elimination of new HIV infections. Methods: A literature review of published and unpublished documents, including programme data and presentations, was conducted. Results and discussion: Cambodia classifies its response to one of the most serious HIV epidemics in Asia into three phases. In Phase I (1991–2000), when adult HIV prevalence peaked at 1.7% and incidence exceeded 20,000 cases, a nationwide HIV prevention programme targeted brothel‐based sex work. Voluntary confidential counselling and testing and home‐based care were introduced, and peer support groups of people living with HIV emerged. Phase II (2001–2011) observed a steady decline in adult prevalence to 0.8% and incidence to 1600 cases by 2011, and was characterized by: expanding antiretroviral treatment (coverage reaching more than 80%) and continuum of care; linking with tuberculosis and maternal and child health services; accelerated prevention among key populations, including entertainment establishment‐based sex workers, men having sex with men, transgender persons, and people who inject drugs; engagement of health workers to deliver quality services; and strengthening health service delivery systems. The third phase (2012–2020) aims to attain zero new infections by 2020 through: sharpening responses to key populations at higher risk; maximizing access to community and facility‐based testing and retention in prevention and care; and accelerating the transition from vertical approaches to linked/integrated approaches. Conclusions: Cambodia has tailored its prevention strategy to its own epidemic, established systematic linkages across different services and communities, and achieved nearly universal coverage of HIV services nationwide. Still, the programme must continually (re)prioritize the most effective and efficient interventions, strengthen synergies between programmes, contribute to health system strengthening, and increase domestic funding so that the gains of the previous two decades are sustained, and the goal of zero new infections is reached., Introduction Situated in the heart of South East Asia, Cambodia is a low‐income country that is recovering from several decades of regional and internal conflict. Its population of 14.86 million [...]

Published
2014
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28. Achieving universal access and moving towards elimination of new HIV infections in Cambodia

Author

Vun, Mean Chhi, Fujita, Masami, Rathavy, Tung, Eang, Mao Tang, Sopheap, Seng, Sovannarith, Samreth, Chhorvann, Chhea, Vanthy, Ly, Sopheap, Oum, Welle, Emily, Ferradini, Laurent, Sedtha, Chin, Bunna, Sok, and Verbruggen, Robert

Subjects
Epidemics -- Research -- Cambodia, HIV infection -- Health aspects -- Research -- Risk factors -- Development and progression -- Patient outcomes -- Care and treatment, Health
Abstract

Introduction: In the mid-1990s, Cambodia faced one of the fastest growing HIV epidemics in Asia. For its achievement in reversing this trend, and achieving universal access to HIV treatment, the country received a United Nations millennium development goal award in 2010. This article reviews Cambodia's response to HIV over the past two decades and discusses its current efforts towards elimination of new HIV infections. Methods: A literature review of published and unpublished documents, including programme data and presentations, was conducted. Results and discussion: Cambodia classifies its response to one of the most serious HIV epidemics in Asia into three phases. In Phase I (1991-2000), when adult HIV prevalence peaked at 1.7% and incidence exceeded 20,000 cases, a nationwide HIV prevention programme targeted brothel-based sex work. Voluntary confidential counselling and testing and home-based care were introduced, and peer support groups of people living with HIV emerged. Phase II (2001-2011) observed a steady decline in adult prevalence to 0.8% and incidence to 1600 cases by 2011, and was characterized by: expanding antiretroviral treatment (coverage reaching more than 80%) and continuum of care; linking with tuberculosis and maternal and child health services; accelerated prevention among key populations, including entertainment establishment-based sex workers, men having sex with men, transgender persons, and people who inject drugs; engagement of health workers to deliver quality services; and strengthening health service delivery systems. The third phase (2012-2020) aims to attain zero new infections by 2020 through: sharpening responses to key populations at higher risk; maximizing access to community and facility-based testing and retention in prevention and care; and accelerating the transition from vertical approaches to linked/integrated approaches. Conclusions: Cambodia has tailored its prevention strategy to its own epidemic, established systematic linkages across different services and communities, and achieved nearly universal coverage of HIV services nationwide. Still, the programme must continually (re)prioritize the most effective and efficient interventions, strengthen synergies between programmes, contribute to health system strengthening, and increase domestic funding so that the gains of the previous two decades are sustained, and the goal of zero new infections is reached. Keywords: HIV; response; epidemic; universal access; service linkage; integration., Introduction Situated in the heart of South East Asia, Cambodia is a low-income country that is recovering from several decades of regional and internal conflict. Its population of 14.86 million [...]

Published
2014
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30. Positive Virological Outcomes of HIV-Infected Patients on Protease Inhibitor-Based Second-Line Regimen in Cambodia: The ANRS 12276 2PICAM Study

Author

Ségéral, Olivier, primary, Nerrienet, Eric, additional, Neth, Sansothy, additional, Spire, Bruno, additional, Khol, Vohith, additional, Ferradini, Laurent, additional, Sarun, Saramony, additional, Mom, Chandara, additional, Ngin, Sopheak, additional, Charpentier, Charlotte, additional, Men, Pagnaroat, additional, Mora, Marion, additional, Mean Chhi, Vun, additional, Ly, Penhsun, additional, and Saphonn, Vonthanak, additional

Published
2018
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31. Massive Iatrogenic Outbreak of Human Immunodeficiency Virus Type 1 in Rural Cambodia, 2014–2015

Author

Rouet, François, primary, Nouhin, Janin, primary, Zheng, Du-Ping, primary, Roche, Benjamin, primary, Black, Allison, primary, Prak, Sophearot, primary, Leoz, Marie, primary, Gaudy-Graffin, Catherine, primary, Ferradini, Laurent, primary, Mom, Chandara, primary, Mam, Sovatha, primary, Gautier, Charlotte, primary, Lesage, Gérard, primary, Ken, Sreymom, primary, Phon, Kerya, primary, Kerleguer, Alexandra, primary, Yang, Chunfu, primary, Killam, William, primary, Fujita, Masami, primary, Mean, Chhivun, primary, Fontenille, Didier, primary, Barin, Francis, primary, Plantier, Jean-Christophe, primary, Bedford, Trevor, primary, Ramos, Artur, primary, and Saphonn, Vonthanak, primary

Published
2017
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32. Cluster of HIV Infections Associated With Unsafe Injection Practices in a Rural Village in Cambodia

Author

Saphonn, Vonthanak, primary, Fujita, Masami, additional, Samreth, Sovannarith, additional, Chan, Sodara, additional, Rouet, Francois, additional, Khol, Vohith, additional, Mam, Sovatha, additional, Mom, Chandara, additional, Tuot, Sovannary, additional, Le, Linh-Vi, additional, Ly, Penh Sun, additional, Ferradini, Laurent, additional, and Mean, Chhi Vun, additional

Published
2017
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34. Implementation and Operational Research

Author

Thyda, Lim, primary, Sineng, Sreng, additional, Delvaux, Thérèse, additional, Srean, Chhim, additional, Mary, Sos, additional, Vuochnea, Penh, additional, Chettana, Pav, additional, Nirada, Nim, additional, Sarim, Chel, additional, Chantha, Pich, additional, Thoeun, Yorn, additional, and Ferradini, Laurent, additional

Published
2015
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35. The marriage of science and optimized HIV care in resource-limited settings

Author

Calmy, Alexandra, Pizzocolo, Cecilia, Pizarro, Louis, Brucker, Gilles, Murphy, Robert, Katlama, Christine, Autran, Brigitte, Calvez, Vincent, Carcelain, Guislaine, Girard, Pierre Marie, Marcelin, Anne-Geneviève, Tubiana, Roland, Descamps, Diane, Fontanet, Arnaud, Peytavin, Gilles, Rouzioux, Christine, Balkan, Suna, Bradol, Jean Hervé, Ferradini, Laurent, Goemaere, Eric, Humblet, Pierre, Mezger, Nathalie, Van Roey, Jens, Von Schoen-Angerer, Tido, Szumilin, Elizabeth, Bonnet, Fabrice, Clumeck, Nathan, Dabis, François, Delaporte, Éric, DelFraissy, Jean-Francois, Eholie, Serge, Sow, Papa Salif, Gilkes, Charles, Hill, Andrew, Lalvani, Paul, Pujades, Mar, Calmy, Alexandra, Pizzocolo, Cecilia, Pizarro, Louis, Brucker, Gilles, Murphy, Robert, Katlama, Christine, Autran, Brigitte, Calvez, Vincent, Carcelain, Guislaine, Girard, Pierre Marie, Marcelin, Anne-Geneviève, Tubiana, Roland, Descamps, Diane, Fontanet, Arnaud, Peytavin, Gilles, Rouzioux, Christine, Balkan, Suna, Bradol, Jean Hervé, Ferradini, Laurent, Goemaere, Eric, Humblet, Pierre, Mezger, Nathalie, Van Roey, Jens, Von Schoen-Angerer, Tido, Szumilin, Elizabeth, Bonnet, Fabrice, Clumeck, Nathan, Dabis, François, Delaporte, Éric, DelFraissy, Jean-Francois, Eholie, Serge, Sow, Papa Salif, Gilkes, Charles, Hill, Andrew, Lalvani, Paul, and Pujades, Mar

Abstract

SCOPUS: no.j, info:eu-repo/semantics/published

Published
2008

39. Prevalence, Risk Factors, and Impact on Outcome of Cytomegalovirus Replication in Serum of Cambodian HIV-Infected Patients (2004-2007)

Author

Micol, Romain, primary, Buchy, Philippe, additional, Guerrier, Gilles, additional, Duong, Veasna, additional, Ferradini, Laurent, additional, Dousset, Jean-Philippe, additional, Guerin, Philippe J, additional, Balkan, Suna, additional, Galimand, Julie, additional, Chanroeun, Hak, additional, Lortholary, Olivier, additional, Rouzioux, Christine, additional, Fontanet, Arnaud, additional, and Leruez-Ville, Marianne, additional

Published
2009
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42. Severe FOXP3+ and Naïve T Lymphopenia in a Non-IPEX Form of Autoimmune Enteropathy Combined With an Immunodeficiency

Author

Zuber, Julien, primary, Viguier, Manuelle, additional, Lemaitre, Fabrice, additional, Senée, Valérie, additional, Patey, Natacha, additional, Elain, Gaëlle, additional, Geissmann, Frédéric, additional, Fakhouri, Fadi, additional, Ferradini, Laurent, additional, Julier, Cécile, additional, and Bandeira, Antonio, additional

Published
2007
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43. Supervised versus unsupervised antimalarial treatment with six-dose artemether-lumefantrine: pharmacokinetic and dosage-related findings from a clinical trial in Uganda

Author

Checchi, Francesco, primary, Piola, Patrice, additional, Fogg, Carole, additional, Bajunirwe, Francis, additional, Biraro, Samuel, additional, Grandesso, Francesco, additional, Ruzagira, Eugene, additional, Babigumira, Joseph, additional, Kigozi, Isaac, additional, Kiguli, James, additional, Kyomuhendo, Juliet, additional, Ferradini, Laurent, additional, Taylor, Walter RJ, additional, and Guthmann, Jean-Paul, additional

Published
2006
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46. Selective Accumulation of Mature DC-Lamp+ Dendritic Cells in Tumor Sites Is Associated with Efficient T-Cell-Mediated Antitumor Response and Control of Metastatic Dissemination in Melanoma

Author

Movassagh, Mojgan, primary, Spatz, Alain, additional, Davoust, Jean, additional, Lebecque, Serge, additional, Romero, Pedro, additional, Pittet, Mikaël, additional, Rimoldi, Donata, additional, Liénard, Danièle, additional, Gugerli, Oliver, additional, Ferradini, Laurent, additional, Robert, Caroline, additional, Avril, Marie-Françoise, additional, Zitvogel, Laurence, additional, and Angevin, Eric, additional

Published
2004
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48. Characterization of antigen-specific repertoire diversity following in vitro restimulation by a recombinant adenovirus expressing human cytomegalovirus pp65

Author

Hamel, Yamina, primary, Rohrlich, Pierre, additional, Baron, Véronique, additional, Bonhomme, Delphine, additional, Rieux-Laucat, Frederic, additional, Necker, Antje, additional, Lemonnier, François, additional, Ferradini, Laurent, additional, Fischer, Alain, additional, and Cavazzana-Calvo, Marina, additional

Published
2003
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