1. Serum Vitamin D Levels and Life-Threatening Respiratory Syncytial Virus Infection in Previously Healthy Infants.
- Author
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Ferolla, F Martin, Yfran, E Walter, Ballerini, M Gabriela, Caratozzolo, Ana, Toledano, Analía, Giordano, Ana C, Acosta, Patricio L, Cassinelli, Hamilton, Bergada, Ignacio, Ropelato, M Gabriela, Contrini, María M, López, Eduardo L, Network, GUTI Respiratory Infections, and GUTI Respiratory Infections Network
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RESPIRATORY syncytial virus infections , *VITAMIN D , *INFANTS , *RESPIRATORY syncytial virus , *HUMAN metapneumovirus infection , *SEVERITY of illness index , *RESEARCH funding , *LONGITUDINAL method - Abstract
Background: 25-hydroxyvitamin D (VD) effects on lung function and immune-modulation might affect respiratory syncytial virus (RSV) infection outcomes. We aimed to assess VD levels on admission and their association with life-threatening RSV disease (LTD).Methods: A prospective cohort study was conducted during 2017-2019. Previously healthy infants aged <12 months, hospitalized with a first episode of RSV infection, were enrolled. LTD was defined by need for intensive care and ventilatory support. Serum VD levels <20 ng/mL were categorized as deficient, and 20-29.9 ng/mL as insufficient.Results: Of 125 patients studied, 73 (58%) were male. Median age was 4 months. Twenty-two patients developed LTD. No differences in viral load were seen between cases with LTD and controls (P = .94). Patients who developed LTD had significantly lower VD levels: median 18.4 ng/mL (IQR, 15.1-26.9 ng/mL) versus 31.7 ng/mL (IQR, 23.6-42.0 ng/mL), P < .001; 59% of infants with LTD had VD deficiency compared with 12% in those with better outcome. Multivariable regression analysis confirmed VD deficiency as a risk factor (odds ratio, 11.83; 95% confidence interval, 3.89-35.9; P < .001).Conclusions: These findings provide additional evidence for the development of strategies to prevent severe RSV infections. [ABSTRACT FROM AUTHOR]- Published
- 2022
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