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Abstract Background A common genetic variant at the glutamate-ammonia ligase (GLUL) locus has been previously associated with an increased risk of coronary artery disease (CAD) as well as alterations of glutamic acid metabolism and the γ-glutamyl cycle in individuals with type 2 diabetes (T2D). Here we investigated whether less frequent variants in GLUL and 15 additional genes in these pathways are associated with differences in CAD risk in T2D. Methods Coding sequences and regulatory elements of these genes were sequenced in 2,394 individuals with T2D from three CAD case/control sets. Results Ninety-six variants with minor allele frequency [MAF]

Background Gait speed is associated with a higher prevalence of balance disorders in older adults residing at high altitudes. This study investigated this association in older adults from 12 high-altitude Andean Peruvian communities. Methods We performed a secondary data analysis from an analytical cross-sectional study of adults >60 years of age, residing in 12 high-altitude Andean Peruvian communities, enrolled between 2013 and 2019. The exposure and outcome variables were gait speed (categorized in tertiles), and balance disorders (defined as a functional reach value of ≤20.32 cm), respectively. We built generalized linear models of the Poisson family with a logarithmic link function and robust variances, and estimated crude prevalence ratios (cPR) and adjusted prevalence ratios (aPR) with 95% confidence intervals (CIs). Results We analyzed 418 older adults; 38.8% (n=162) were male, and the mean age was 73.2±6.9 years. The mean gait speed and functional reach were 0.66±0.24 m/s and 19.9±6.48 cm, respectively. In the adjusted regression model, the intermediate (aPR=1.88; 95% CI, 1.39–2.55; p

RESUMO Esta pesquisa aborda a relação entre agricultura e indústria no processo de acumulação de capital no Brasil do final dos anos 20 até o início dos anos 60. É uma exploração da dinâmica das articulações intersetoriais no período e dos efeitos das políticas estaduais sobre essas dinâmicas. Foi demonstrado que, embora a agricultura brasileira tenha desempenhado suas cinco funções tradicionais ao longo do período de 1930 a 1960, seu desempenho não foi uma história de progresso constante em cada frente. Durante os anos 50, as cinco funções pareciam conter contradições internas associadas ao estabelecimento das indústrias de consumo durável e de bens de capital pesado. As políticas de Estado foram vistas como reforçando as contradições que contribuíram para a crise da economia brasileira do início dos anos sessenta.

Abstract Background The prevalence of frailty and activities of daily living (ADL) disability may be higher in high-altitude Andean regions, due to chronic hypoxia, malnutrition, and physical challenges. and their association is relevant. This study aimed to evaluate the association between frailty and ADL disability among older adults residing in the Totos district in Peru during the year 2022. Methods A cross-sectional study was conducted in Totos district (mean altitude: 3286 m above sea level), located in Ayacucho, Peru, during 2022. A complete census was employed including residents aged 60 and above. The exposure variable was frailty, defined by fulfilling 3 or more criteria of the Fried phenotype. The outcome variable was ADL disability, defined as a score below 95 on the Barthel index. Generalized linear models with a Poisson family, logarithmic link function, and robust variances were employed to estimate crude prevalence ratios and adjusted prevalence ratios (aPRs), along with their corresponding 95% confidence intervals (CIs). Results We evaluated 272 older adults with a mean age of 74 years, of whom 59.9% were female, 62.1% were cohabiting or married and 83.1% had not completed primary education. We found that 19.5% were frail, while 51.1% had ADL disability. In the adjusted regression model, we found frailty increased the prevalence of ADL disability (aPR = 1.77; 95%CI: 1.44–2.16; p

Summary: Purpose: Older adults have a higher risk of malnutrition and hospitalization and, likewise, malnutrition can be a risk factor for hospitalization. The purpose of the present study was to determine the possible association between malnutrition and hospitalization in older adults at the Naval Medical Center “Cirujano Mayor Santiago Távara'' in Peru. Patients and Methods: A cross-sectional analytical study was conducted in older adults over 60 years of age attended by the outpatient and Day Clinic during the period 2010–2015. Malnutrition was assessed using the Mini Nutritional Assessment scale. Multivariate analysis of the association between malnutrition and hospitalization with control of confounding variables was performed using a Poisson regression model with robust variance, obtaining an adjusted prevalence ratio (aPR). Results: The study included 1865 older adults. 58.7% were male, and 46% were between 70 and 80 years of age. 16.3% had malnutrition, 80.6% had at least one emergency department visit, and 35.6% were hospitalized at least once. Multivariate analysis showed a statistically significant association between malnutrition and hospitalization (aPR = 3.22; 95% confidence interval [CI]: 2.56–4.03), as well as between depressive symptoms and hospitalization (aPR = 1.54; 95% CI: 1.23–1.93). On the other hand, emergency department visits were associated with a lower frequency of hospitalization (aPR = 0.70; 95% CI: 0.54–0.90). Conclusion: Malnutrition and depressive symptoms were associated with hospitalization in retired naval personnel and their families at the Naval Medical Center, while emergency department visits constituted a protective factor.

Abstract Textile dyes are frequently disposable in aqueous effluents, making it difficult to remove them from industrial effluents before their release to natural waters. This paper deals with the fabrication of cellulose-based adsorbents by reacting nanocelulose crystalline (nanocel) with N-[3-(trimethoxysilyl)propyl]ethylenediamine (TMSPEDA), forming the hybrid (silylpropyl)ethylenediamine@nanocellulose (SPEDA@nanocel), which was employed as adsorbent for the uptake of reactive yellow 2 dye (RY-2) from aqueous effluents. Characterisation of SPEDA@nanocel was carried out using FTIR, SEM–EDS, XRD, TGA, surface area, pHpzc, and hydrophobicity/hydrophilicity ratio (HI). Also, adsorption studies were thoroughly investigated. The effect of initial pH indicated that the maximum uptake of RY-2 takes place at pH 2, which is an indication of the electrostatic mechanism. The kinetic data carried out with 250 and 500 mg L−1 RY-2 with SPEDA@nanocel followed better the nonlinear fractional-like pseudo-first-order model. The t0.5 and t0.95 for the dye uptake were about 30 and 141 min, respectively. The equilibrium data from 10 to 45 °C indicated that the Liu isotherm model was the best-fitted isothermal model. The maximum sorption capacity attained was 112.3 mg g−1 at 45 °C. The thermodynamic data have shown that the equilibrium was favorable and endothermic, and the ΔH° was compatible with an electrostatic attraction between RY-2 and SPEDA@nanocel. Experiments of desorption of loaded adsorbent showed promising results for real applications since at least 5 adsorption/desorption cycles could be employed without significant changes in the recovery and with high precision.

Abstract The lymphatic circulation plays a crucial role in maintaining fluid balance and supporting immune responses by returning serum proteins and lipids to the systemic circulation. Lymphatic leaks, though rare, pose significant challenges post-radical neck surgery, oesophagectomy, and thoracic or retroperitoneal oncological resections, leading to heightened morbidity and mortality. Managing lymphatic leaks necessitates consideration of aetiology, severity, and volume of leakage. Traditionally, treatment involved conservative measures such as dietary restrictions, drainage, and medical management, with surgical intervention reserved for severe cases, albeit with variable outcomes and extended recovery periods. Lymphography, introduced in the 1950s, initially served as a diagnostic tool for lymphoedema, lymphoma, tumour staging, and monitoring chemotherapy response. However, its widespread adoption was impeded by alternative techniques like Computed Tomography, learning curves, and its associated complications. Contemporary lymphatic interventions have evolved, favouring nodal lymphangiography over pedal lymphangiography for its technical simplicity and reduced complexity. Effective management of chylous leaks mandates a multimodal approach encompassing clinical evaluation and imaging techniques. In cases where conservative management proves ineffective, embolization through conventional lymphangiography by bipedal dissection or intranodal injection emerges as a viable option. This review underscores the importance of a comprehensive approach to diagnosing and treating lymphatic leaks, highlighting advancements in imaging and therapeutic interventions that enhance patient outcomes.

Background Sarcopenia is a musculoskeletal disease involving the reduction of muscle mass, strength, and performance. Handgrip strength (HGS) measurements included in frailty assessments are great biomarkers of aging and are related to functional deficits. We assessed the association between potential influencing factors and HGS asymmetry in older Peruvian adults. Methods We used a database of the Peruvian Naval Medical Center "Cirujano Santiago Távara" located in Callao, Peru. All the patients included were ≥60 years old and had an HGS measurement in the dominant and non-dominant hand. Results From a total of 1,468 patients, 74.66% had HGS asymmetry. After adjustment, calf circumference weakness (adjusted prevalence ratio [aPR]=1.08; 95% confidence interval [CI], 1.01–1.15), falls risk (aPR = 1.08; 95% CI, 1.02–1.16), and an altered Lawton index (aPR=0.92; 95% CI, 0.84–0.99) were associated with HGS asymmetry. Conclusion Our findings suggest that HGS asymmetry should be measured along with other geriatric assessments used to evaluate health outcomes in the elderly to enhance health promotion and prevention aimed at preserving muscle strength to curb functional limitations in the elderly.

This study introduces a novel silica-graphene oxide@chitosan (SiGO@CS) material as a packed biosorbent for microextraction by packed sorbent (MEPS), followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis of pesticides (atrazine and thiamethoxam) and antibiotics (ceftiofur and sulfonamide) in food samples. The graphene-based aerogel was modified with varying percentages of silica-graphene oxide/chitosan (w/w) and characterized to confirm successful chitosan incorporation. Optimization of the MEPS protocol, using 24–1 and 23 experimental designs, identified draw/eject and washing cycles as the most influential parameters for extraction efficiency. The SiGO@CS biosorbent with 80 % CS/SiGO (w/w) exhibited superior extraction efficiency compared to other ratios and commercial sorbents. The method demonstrated excellent linearity for all analytes (R² > 0.9900), with low limits of detection (LOD) and quantification (LOQ) ranging from 0.020 to 0.045 µg l-1 and 0.045 to 1.0 µg l-1 for pesticides, respectively, and 5 to 15 µg l-1 and 15 to 20 µg l-1 for antibiotics, respectively. Trueness values were within 82 % to 109 %. The method's green credentials were confirmed using AGREEprep and the Green Analytical Procedure Index (GAPI) approach, highlighting sorbent reusability (over 15 times) and rapid analytical throughput (5 min per sample) with low use of pre-treated sample extract volume (500 µL). The application to local corn, tomato, and milk samples confirmed the detection and quantification of thiamethoxam and atrazine at concentrations above the recommended ingestion per day for one sample of tomato and corn out of the three samples analyzed. Furthermore, using the novel SiGO@CS biosorbent in the MEPS protocol offers a green, high-performance analytical alternative to traditional sorbent phases, with the potential for evaluating trace levels of pesticides and antibiotics in food matrices.

Neuromorphic computing relies on event-based, energy-efficient communication, inherently implying the need for conversion between real-valued (sensory) data and binary, sparse spiking representation. This is usually accomplished by using the real-valued data as current input to a spiking neuron model and tuning the neuron’s parameters to match a desired – often biologically inspired – behavior. To support the investigation of neuron models and parameter combinations to identify suitable configurations for neuron-based encoding of sample-based data into spike trains we developed the WiN-GUI. Thanks to the generalized LIF model implemented by default, next to the LIF and Izhikevich neuron models, many spiking behaviors can be investigated out of the box offering the possibility of tuning biologically plausible responses to the input data. The GUI is provided open source and with documentation and is easy to extend with further neuron models and personalize with data analysis functions.

ABSTRACT Objective Polycystic ovary syndrome (PCOS) is an endocrine disease characterized by metabolic, reproductive, and psychological manifestations. Growth and differentiation factor 15 (GDF-15) is a cytokine associated with metabolic and inflammatory disorders. Metformin is commonly used for the treatment of PCOS. We investigated the relationship between GDF-15 levels and PCOS, the effect of metformin on GDF-15 levels, and potential biologic pathways related to GDF-15. Subjects and methods The study included 35 women with PCOS and 32 women without PCOS (controls). Both groups were compared in terms of GDF-15 levels. Additional analysis was conducted on samples from 22 women with PCOS who were treated with either metformin (n = 7) or placebo (n = 15), retrieved from a previous randomized, controlled trial. Levels of GDF-15 were measured using MILLIPLEX. The biologic pathways related to GDF-15 were evaluated using the databases STRING, SIGNOR, and Pathway Commons. The statistical analysis was conducted using the software SPSS. Results Levels of GDF-15 were higher in the PCOS group compared with the non-PCOS group (p = 0.039). Among women with PCOS, GDF-15 levels were higher in those treated with metformin compared with placebo (p = 0.007). The proteins related to GDF-15 overlapped between the databases, and a significant interaction was found between GDF-15 and proteins related to PCOS and its complications, including those related to estrogen response, oxidative stress, ovarian infertility, interleukin (IL)-18, IL-4, the ratio of advanced glycation end products to their receptor (AGE/RAGE), leptin, transforming growth factor beta (TGF-β), adipogenesis, and insulin. Conclusion The findings of the present study suggest a relationship between GDF-15 and PCOS and a potential increase in GDF-15 levels with metformin treatment. An additional finding was that GDF-15 could be involved in biologic pathways related to PCOS complications.

Abstract Jacobsite is a relatively rare mineral of composition MnFe2O4, found in Urandi (Bahia State) in Brazil. It is also a common species in the deep-sea manganese nodules, attracting the interest of many mineral-extracting companies. Because of its spinel constitution similar to magnetite, Jacobsite is commonly called a manganese-ferrite. However, the manganese/iron content may vary substantially according to its origin, demanding specific studies in each case. The Jacobsite mineral inspired our laboratory synthesis of the analogous manganese ferrite nanoparticles. The direct synthesis by the coprecipitation method has not been successful; however, it can be carried in the presence of citrate ions, yielding strongly magnetic nanoparticles, with a maximum magnetization of 45.6 emu.g1. Although they were structurally identical to Jacobsite, the mineral from Bahia exhibited a rather weak magnetism, because it involves a ferrimagnetic coupling. For this reason, the synthetic method seems to provide a better way of obtaining strongly magnetic manganese ferrites. These magnetic nanoparticles have been investigated in detail, including their interaction with diatoms, providing interesting magnetic bio-silicate carriers in drug delivery.

Extreme weather has made 2023 virtually certain to be the warmest year on record, signaling unprecedented climate and biodiversity crises. Brazil, the world’s most biodiverse country, with two hotspots and complex social and economic layers, has experienced escalating environmental degradation over the past years. Alarming rates of native vegetation loss, wildfires, severe and prolonged droughts, and heatwaves have adversely impacted several Brazilian ecosystems and societies. Despite the country’s decisive role in global carbon neutrality, bridging the gap between Brazil’s discourse on the international stage and its concrete actions at home remains a significant challenge. This correspondence, a collective plea from scientists across various sectors, underscores the urgent imperative for national engagement and commitment to halt and mitigate these crises. We aim to catalyze a robust international public debate, influencing Brazilian decision-makers to chart a concrete sustainable pathway. Aligned with global initiatives, we emphasize the crucial interplay between national and international efforts in combating climate change and the conservation of biodiversity and socio-biodiversity.

Abstract Background Neutrophils are granulocytes with essential antimicrobial effector functions and short lifespans. During infection or sterile inflammation, emergency granulopoiesis leads to release of immature neutrophils from the bone marrow, serving to boost circulating neutrophil counts. Steady state and emergency granulopoiesis are incompletely understood, partly due to a lack of genetically amenable models of neutrophil development. Methods We optimised a method for ex vivo production of human neutrophils from CD34+ haematopoietic progenitors. Using flow cytometry, we phenotypically compared cultured neutrophils with native neutrophils from donors experiencing emergency granulopoiesis, and steady state neutrophils from non-challenged donors. We carry out functional and proteomic characterisation of cultured neutrophils and establish genome editing of progenitors. Results We obtain high yields of ex vivo cultured neutrophils, which phenotypically resemble immature neutrophils released into the circulation during emergency granulopoiesis. Cultured neutrophils have similar rates of ROS production and bacterial killing but altered degranulation, cytokine release and antifungal activity compared to mature neutrophils isolated from peripheral blood. These differences are likely due to incomplete synthesis of granule proteins, as demonstrated by proteomic analysis. Conclusion Ex vivo cultured neutrophils are genetically tractable via genome editing of precursors and provide a powerful model system for investigating the properties and behaviour of immature neutrophils.

Abstract Investigative exploration and foraging leading to food consumption have vital importance, but are not well-understood. Since GABAergic inputs to the lateral and ventrolateral periaqueductal gray (l/vlPAG) control such behaviors, we dissected the role of vgat-expressing GABAergic l/vlPAG cells in exploration, foraging and hunting. Here, we show that in mice vgat l/vlPAG cells encode approach to food and consumption of both live prey and non-prey foods. The activity of these cells is necessary and sufficient for inducing food-seeking leading to subsequent consumption. Activation of vgat l/vlPAG cells produces exploratory foraging and compulsive eating without altering defensive behaviors. Moreover, l/vlPAG vgat cells are bidirectionally interconnected to several feeding, exploration and investigation nodes, including the zona incerta. Remarkably, the vgat l/vlPAG projection to the zona incerta bidirectionally controls approach towards food leading to consumption. These data indicate the PAG is not only a final downstream target of top-down exploration and foraging-related inputs, but that it also influences these behaviors through a bottom-up pathway.

This work investigates the classical and quantum duality between the SIM(1)-Maxwell-Chern-Simons (MCS) model and its self-dual counterpart. Initially, we focus on free-field cases to establish equivalence through two distinct approaches: comparing the equations of motion and utilizing the master Lagrangian method. In both instances, the classical correspondence between the self-dual and MCS dual fields undergoes modifications due to very special relativity (VSR). Specifically, the duality is established when the associated VSR-mass parameters are identical, and the dual field is introduced through a non-local VSR correction. Furthermore, we analyze the duality when the self-dual model is minimally coupled to fermions. As a result, we demonstrate that Thirring-like interactions, corrected for non-local VSR contributions, are included in the MCS model. Additionally, we establish the quantum equivalence of the models by performing a functional integration of the fields and comparing the resulting effective Lagrangians.

Interventional oncology (IO) has emerged as a pivotal field within interventional radiology (IR), gaining prominence in the past three decades. It has transcended its initial role in cancer care, expanding beyond biopsies and vascular access to offer a spectrum of percutaneous and transarterial procedures, transforming into a curative and palliative discipline. However, implementing IO in children presents distinctive challenges. While the technical aspects of IO procedures mirror those in adults, paediatric cases require specialised considerations. Radiologists must possess an in-depth understanding of the paediatric disease, tailor imaging modalities to the case, discern unique risks, and interpret disease markers specific to children. Notably, paediatric tumour biopsies demand significantly larger tissue samples for genetic sequencing, staging, and prognostication. Paediatric IO also confronts procedural disparities. Tumours in children may be larger relative to body size, necessitating precise radioembolisation dose calculations. The proximity of critical structures in small bodies amplifies the risk of collateral damage. When performing percutaneous ablation and endovascular therapies, these challenges must also be faced so that radiologists can navigate these complex clinical and technical considerations to ensure safe and effective interventions, all while prioritising the well-being of their young patients. This review summarises the current role and future opportunities for IO in paediatric cancer.

RESUMO O artigo analisa as relações entre inflação, imposto inflacionário e déficit público para a economia brasileira durante os anos oitenta. Inicialmente, essas relações são descritas de forma um tanto simplista usando o chamado modelo de imposto inflacionário. As hipóteses de trabalho são (1) existe um limite absoluto para o financiamento do déficit do governo pelo imposto inflacionário; (2) um determinado montante de imposto inflacionário pode ser arrecadado com uma taxa de inflação alta ou baixa e (3) o imposto inflacionário arrecadado pelo governo depende das condições monetárias da economia. Usando este arcabouço analítico, um exercício de simulação é realizado para estimar o financiamento fiscal inflacionário do déficit público da economia brasileira durante o período 1982-88. As principais conclusões são: (1) as condições do financiamento tributário inflacionário mudam após 1986, quando o foco da política econômica se desloca da ortodoxia convencional para o que se chama de abordagem heterodoxa; (2) a aceleração da inflação enfraqueceu radicalmente a capacidade do governo de arrecadar impostos inflacionários e (3) nessas condições, o congelamento de preços e a fixação da taxa de câmbio podem ser considerados necessários para assegurar a transição de um nível de inflação alto para baixo.

Abstract Management of vitreoretinal disorders (e.g., neovascular age-related macular degeneration [nAMD] and diabetic macular edema [DME]) have assumed the standard therapy of lifelong anti-VEGF injections with drugs like aflibercept, brolucizumab, ranibizumab and bevacizumab. However, the burden imposed on patients is a major deterrent for continual therapy and recovery. Faricimab, a bispecific antibody, blocking both VEGF-A and Ang-2 molecules, produces a comparable functional and anatomical results, with less injections, significantly reducing patient burden. Visual acuity, safety, adverse effects, and anatomical outcomes are discussed in the pivotal clinical trials (YOSEMITE/RHINE and TENAYA/LUCERNE), and early data from real-world studies (TRUCKEE, TAHOE, FARWIDE-DME, FARETINA and others). In YOSEMITE and RHINE, faricimab demonstrated non-inferior vision gains, better anatomical outcomes compared to aflibercept every 8 weeks. Faricimab in the personalized treatment interval (PTI), after week 96, achieved 12-week interval in 78.1% of the patients and 16-week interval in 62.3%. TENAYA and LUCERNE reported comparable best corrected visual acuity (BCVA) improvement and better anatomic outcomes during head-to-head phase, parallel to aflibercept, at its 8-week treatment schedule. Faricimab in the PTI regimen, after week 96 achieved 12-week interval in 77.8% of the patients and 16-week interval in 63.1%. Safety of faricimab has been comparable to aflibercept in these pivotal trials. Real-world data supports the data from the pivotal studies regarding the efficacy and safety profile of faricimab in heterogenous real world patient population. Moreover, in previously treated patients, it also demonstrated a faster fluid resolution, good safety profile. Considering faricimab has demonstrated anatomic and durability benefit in the treatment of nAMD and DME, additional data from ongoing extension clinical trials, AVONELLE-X and RHONE-X will help understand longer term outcomes for patients treated with faricimab as well as patients switching from aflibercept to faricimab after finishing the pivotal trials. Longer term data from the real-world studies will also continue to contribute to our understanding of long-term efficacy, safety and durability in the real world patient population.

Abstract Background Autism Spectrum Disorder (ASD) diagnosis can be aided by approaches based on eye-tracking signals. Recently, the feasibility of building Visual Attention Models (VAMs) from features extracted from visual stimuli and their use for classifying cases and controls has been demonstrated using Neural Networks and Support Vector Machines. The present work has three aims: 1) to evaluate whether the trained classifier from the previous study was generalist enough to classify new samples with a new stimulus; 2) to replicate the previously approach to train a new classifier with a new dataset; 3) to evaluate the performance of classifiers obtained by a new classification algorithm (Random Forest) using the previous and the current datasets. Methods The previously approach was replicated with a new stimulus and new sample, 44 from the Typical Development group and 33 from the ASD group. After the replication, Random Forest classifier was tested to substitute Neural Networks algorithm. Results The test with the trained classifier reached an AUC of 0.56, suggesting that the trained classifier requires retraining of the VAMs when changing the stimulus. The replication results reached an AUC of 0.71, indicating the potential of generalization of the approach for aiding ASD diagnosis, as long as the stimulus is similar to the originally proposed. The results achieved with Random Forest were superior to those achieved with the original approach, with an average AUC of 0.95 for the previous dataset and 0.74 for the new dataset. Conclusion In summary, the results of the replication experiment were satisfactory, which suggests the robustness of the approach and the VAM-based approaches feasibility to aid in ASD diagnosis. The proposed method change improved the classification performance. Some limitations are discussed and additional studies are encouraged to test other conditions and scenarios.

Microbially induced calcite precipitation is a soil improvement technique in which bacteria are used to produce calcium carbonate (biocement), precipitated after the hydrolysis of urea by the urease enzyme present in the microorganisms. This technique is becoming popular, and there have been several real cases of its use; however, the dosages and reaction times used to attain a required percentage of biocement mainly stem from previous experimental tests, and calculations are not performed. Thus, it is fundamental to have more robust tools and the existence of numerical models able to compute the amount precipitated, such as the one proposed in this paper, can be an important contribution. A two-phase porous medium model is created to analyse the precipitation process. The solid phase contains soil particles, bacteria and biocement, while the fluid phase contains water, urea and other dissolved species. A coupled bio-chemo-hydro-mechanical finite element formulation is defined, embodying the biochemical reaction, water seepage, the diffusion of species and soil deformation. The main novelties of this study are as follows: (i) porosity changes are computed considering the generation of solid mass due to biocement precipitation, and, therefore, soil permeability is updated during the calculation, with these highly coupled equations being integrated in time simultaneously and not sequentially; and (ii) the model is calibrated with experimental tests conceived especially for this purpose. The model is then used to compute the biocement precipitated in a sand column simulating a real experimental test. The results of the simulations present a distribution of biocement along the column closer to that observed in the experimental tests, validating the model.

Backcrossing between Sikitita and its male parent Arbequina, offers the possibility to check the suitability of different self-incompatibility models proposed for olive. To determine Sikitita’s response to self- and cross-pollination treatments, including pollination with its father Arbequina, we compared the parameters following pollen–pistil interaction, the resulting initial and final fruit set, and the paternity of the seeds produced under different crosses. The results showed that Sikitita behaves as a self-incompatible cultivar due to the inhibition of pollen tube growth in the pistil of self-pollinated flowers. This incompatibility reaction led to a significant reduction of self-fertilization and fruit set. Seed paternity analyses confirmed the self-incompatibility response of Sikitita. A similar incompatibility response was observed in Sikitita flowers when hand-pollinated with pollen of Arbequina and Koroneiki. On the contrary, cross-pollination with Arbosana gave excellent results, with analyses showing that pollen of Arbosana is largely preferred by Sikitita to father its seeds more than the pollen of other cultivars presented in the orchard. The backcross failure of Sikitita with Arbequina pollen suggests that the self-incompatibility system in olives is not of the gametophytic type. In contrast, pollination tests fit features of previously reported sporophytic self-incompatibility systems. However, some amendments are proposed, among them the incompatibility groups for Sikitita and Koroneiki.

Chlamydia trachomatis (C. trachomatis) screening and treatment in pregnancy allows the opportunity to reduce adverse pregnancy and neonatal outcomes worldwide. Although C. trachomatis infection is easily treated and cured with antibiotics, only some countries have routine pregnancy screening and treatment programs. We therefore evaluated whether just one maternal screening for C. trachomatis is enough to prevent adverse pregnancy and negative neonatal outcomes. Among the 4087 first-time gynecological–obstetric consultations granted at the National Institute of Perinatology in 2018, we selected the study population according to a case–cohort design. Antenatal C. trachomatis screening and treatment interventions were performed on 628 pregnant women using COBAS® TaqMan CT. C. trachomatis DNA was also detected in samples from 157 infants of these mothers. In the maternal cohort, incidence of C. trachomatis infection was 10.5%. The vertical transmission rate was 1.5% for the cohort of mothers who tested positive for C. trachomatis and received treatment, and 29.7% for those with a negative test. By evaluating symptomatic neonatal infection, the hazard rate of perinatal pneumonia was 3.6 times higher in C. trachomatis-positive babies than in C. trachomatis-negative babies. Despite the low rate of mother-to-child transmission in women positive for C. trachomatis, possible maternal infection that is not detected in pregnancy significantly increases the risk of neonatal infection with consequent perinatal pneumonia.

We present a mathematical model for agri-food industry residual streams flow management, which serves as a decision support tool for optimizing their valorization. The aim is to determine, under a cost-benefit analysis approach, the best strategy at a global level. The proposed mathematical model provides the optimal valorization scenario, namely the set of routes followed by agri-food industry residual streams that maximizes the total profit obtained. The model takes into account the complete stoichiometry of the residual stream at each step of the valorization route. Furthermore, the model allows for the calculations of different scenarios to support decision-making. The proposed approach is illustrated through a case study using a real-case network of a region. The case study bears evidence that the use of the model can lead to significant profit increases compared to those obtained with current practices. Moreover, notable profit improvements are obtained in the case study if the selling price of all the value-added products considered increases or if the processing cost of the animal feed producer decreases. Therefore, our model enables the detection of key factors that influence the optimal strategy, making it a powerful decision-support tool for optimizing the valorization of agri-food industry residual streams.

NESIM-RT is a specialized tool designed for simulating neuromorphic systems. In this new release we extend its capabilities to include state-of-the art models like the AdexLIF and Izhikevich, and to incorporate dynamic synaptic mechanisms such as Spike-Timing Dependent Plasticity (STDP). With these new features, researchers can now observe in real-time how different parameters influence these models and learning rules, thereby gaining deeper insights into neuronal function and network dynamics.

La videodeglución es un estudio fisiológico y en tiempo real que, al momento, no tiene reemplazo por otra modalidad. Ofrece información relevante sobre el sistema estomatognático del paciente, así como sobre la estructura y la funcionalidad orofaríngea y esofágica. Este estudio cuenta con distintas fases (oral, faríngea y esofágica) en las que se analizan diversas estructuras, así como la funcionalidad de estas a través de degluciones inducidas de diferentes consistencias (semisólido, líquido, sólido). Las patologías que pueden encontrarse son múltiples, siendo algunas de las más frecuentes la disfunción del músculo cricofaríngeo, la penetración/aspiración en la vía aérea, los divertículos y la acalasia. Resulta fundamental su ejecución con una técnica correcta, conociendo previamente la sintomatología, el motivo por el cual fue indicada, la anatomía de las estructuras/cavidades y la fisiología de la deglución. Por lo tanto, una adecuada técnica en la ejecución de la videodeglución y el conocimiento preliminar de la anatomía y la fisiología, así como de los hallazgos y patologías más frecuentes, son fundamentales para una adecuada evaluación del paciente y una correcta interpretación de las imágenes.

La preeclampsia es un trastorno hipertensivo de la gestación que se evidencia durante las últimas semanas de esta. Globalmente, la preeclampsia es la segunda causa de mortalidad materna. Se estima que su incidencia es de aproximadamente un 16% en los países en vías de desarrollo, y llega a superar el 25% en algunos países de Latinoamérica. Se describirán las principales estrategias de prevención de la preeclampsia y su relevancia en el contexto latinoamericano. La búsqueda de información tuvo lugar en PubMed y BVS para las publicaciones realizadas sobre prevención de la preeclampsia, utilizando la expresión de búsqueda (“Disease Prevention” OR “Primary Prevention”) AND (Pre-eclampsia OR Preeclampsia OR “Pre eclampsia”) AND (“Latin America” OR “Central America” OR “South America” OR Caribbean). En PubMed se encontraron 60 y en BVS 42 resultados que responden a la expresión de búsqueda, y fueron seleccionados 18 artículos que discuten estrategias de prevención de la preeclampsia en Latinoamérica. Con estos resultados, se pueden afirmar que, describir las mejores estrategias de prevención de la preeclampsia en Latinoamérica es una tarea pendiente, pues existe una relativa carencia de publicaciones. En consecuencia, se espera que esta revisión motive futuras investigaciones y sea un recurso útil en la actualización médica.

Introducción: La pancreatitis aguda se observa con mayor frecuencia en la edad pediátrica. Actualmente existen guías de recomendaciones para su adecuado diagnóstico y tratamiento. El objetivo de este estudio fue evaluar el nivel de conocimiento de las recomendaciones internacionales sobre pancreatitis aguda de la North American Society for Pediatric Gastroenterology, Hepatology and Nutrition en un grupo de pediatras. Métodos: Estudio observacional, multicéntrico, mediante una encuesta aplicada a médicos pediatras y médicos pediatras en formación. Resultados: El 48.8% de los médicos tenían conocimiento de las guías para tratamiento de pancreatitis aguda en niños. El 72.4% conocían los criterios actuales para el diagnóstico de pancreatitis aguda. No hubo diferencias en la mayoría de las respuestas entre médicos pediatras y médicos pediatras en formación. Conclusiones: Aunque solo la mitad de los encuestados conocían la guía para el diagnóstico y el tratamiento de la pancreatitis aguda, cerca de tres cuartas partes utilizan adecuadamente los criterios para el diagnóstico. Existe adecuado conocimiento sobre la prescripción de antibióticos y el seguimiento posterior a la pancreatitis aguda. Hay déficit en el conocimiento sobre las recomendaciones de la monitorización de los signos vitales y el momento adecuado para realizar la colecistectomía ante una pancreatitis de origen biliar.

Presentamos y reflexionamos sobre las potencialidades de la comunicación pública de la arqueología mediante la enciclopedia Wikipedia, a partir de nuestra experiencia como Equipo de Wikimedistas de la Universidad Nacional de La Plata (WikiUNLP). Wikipedia, una enciclopedia multilingüe, en línea, gratuita, libre y abierta, contiene sesgos geopolíticos, de género y de conocimiento, que son el reflejo de las comunidades que la editan. Nos propusimos reducir estos sesgos mediante la edición de contenidos, entendiendo que mejorar contenidos en Wikipedia es una forma potente de comunicar ciencia. En este trabajo analizamos algunas ediciones realizadas sobre Arqueología, como la creación de biografías de arqueólogas y revistas académicas; y artículos sobre temáticas arqueológicas. En general, identificamos falta de información en los artículos sobre las arqueólogas y las revistas, así como fricciones que éstos deben atravesar para ser considerados relevantes por los editores del Norte Global. Observamos también que la incorporación de referencias y mejora de artículos aumentan el promedio de visitas mensuales. Finalmente, discutimos los desafíos que suponen la Ciencia Abierta y la Comunicación Pública de la Ciencia desde la perspectiva colaborativa que proponen los Proyectos Wikimedia, así como los puntos en común y tensiones entre las comunidades científica y de wikimedistas.

For pheochromocytoma and paraganglioma (PPGL), the efficacy of percutaneous ablative therapies in achieving control of metastatic tumors measuring

Introduction and Objectives: Acute liver failure, also known as fulminant hepatic failure (FHF), includes a spectrum of clinical entities characterized by acute liver injury, severe hepatocellular dysfunction and hepatic encephalopathy. The objective of this study was to assess cerebral autoregulation (CA) in 25 patients (19 female) with FHF and to follow up with seventeen of these patients before and after liver transplantation. Patients and Methods: The mean age was 33.8 years (range 14–56, SD 13.1 years). Cerebral hemodynamics was assessed by transcranial Doppler (TCD) bilateral recordings of cerebral blood velocity (CBv) in the middle cerebral arteries (MCA). Results: CA was assessed based on the static CA index (SCAI), reflecting the effects of a 20–30 mmHg increase in mean arterial blood pressure on CBv induced with norepinephrine infusion. SCAI was estimated at four time points: pretransplant and on the 1st, 2nd and 3rd posttransplant days, showing a significant difference between pre- and posttransplant SCAI (p = 0.005). SCAI peaked on the third posttransplant day (p = 0.006). Categorical analysis of SCAI showed that for most patients, CA was reestablished on the second day posttransplant (SCAI > 0.6). Conclusions: These results suggest that CA impairment pretransplant and on the 1st day posttransplant was re-established at 48–72 h after transplantation. These findings can help to improve the management of this patient group during these specific phases, thereby avoiding neurological complications, such as brain swelling and intracranial hypertension.

Abstract Genotype-by-environment (G×E) interactions can significantly affect crop performance and stability. Investigating G×E requires extensive data sets with diverse cultivars tested over multiple locations and years. The Genomes-to-Fields (G2F) Initiative has tested maize hybrids in more than 130 year-locations in North America since 2014. Here, we curate and expand this data set by generating environmental covariates (using a crop model) for each of the trials. The resulting data set includes DNA genotypes and environmental data linked to more than 70,000 phenotypic records of grain yield and flowering traits for more than 4000 hybrids. We show how this valuable data set can serve as a benchmark in agricultural modeling and prediction, paving the way for countless G×E investigations in maize. We use multivariate analyses to characterize the data set’s genetic and environmental structure, study the association of key environmental factors with traits, and provide benchmarks using genomic prediction models.

The main goal of this study was to verify the best combination of density, moisture content, and feed speed on the surface quality of Pinus elliottii boards aimed at deck manufacturing. The secondary goal was to compare three methods of surface quality assessment. Tangential boards were sampled and sorted by density (level 1: 414 kg·m-³ to 525 kg·m-³; level 2: 526 kg·m-³ to 668 kg·m-³) and moisture content (level 1: 13.5% to 17.5%; level 2: 17.6% to 20.0%). A four-side planer molder was used, at three levels of feed speed (15, 20, and 25 m·min-1). Surface quality was assessed immediately after machining by visual-tactile analysis, stylus surface profilometer reading (parameters Ra, Rz, and Rt), and feed per tooth (fz) measurement. The best surface quality results were obtained with denser (526 kg·m-³ to 668 kg·m-³) and wetter boards (17.6% to 20.0% moisture content) at feed speed 20 m•min-1. This recommendation represents an optimal balance between the quality standard of the deck boards and high productivity. Because of the low cost and because it has some correspondence with the stylus surface profilometer readings, visual-tactile analysis is recommended to assess the surface quality.

In today's rapidly evolving educational landscape, European universities are increasingly relying on digital technologies for collaboration and learning. European Universities, as transnational alliances, aim to reshape higher education by fostering academic exchange and innovation across borders. With over 40 alliances in existence, enhancing virtual mobility and exchange through interconnected learning infrastructures has become imperative. This paper provides insights into Learning Management System (LMS) adoption within European alliances, focusing on the Unite! alliance as a case study. While Unite! demonstrates successful implementation of Moodle as its central LMS, challenges persist in achieving uniformity across all partners. A desktop analysis of European alliances reveals that Moodle might be the most often used LMS in February 2023. A description of the LMS implementation within the Unite! analysis shows as well that a majority uses Moodle – at least as a second LMS. So, although the decision for a federated LMS based on Moodle might be the right one, these results as well indicate the need for tailored technical solutions for future developments for some partners and disparities in lecturers‘ and students‘ concerning a Moodle so that pre-emptive measures to ensure equitable participation are important. Despite these challenges, Unite!'s experience underscores the potential of Moodle as a widely adopted platform, prompting further exploration into solutions like LTI integration.

The primary cause of bottled wine sediment is tartrate crystal precipitation. To prevent this, wines undergo a stabilization process before bottling. The most commonly used method is cold stabilization, which induces the precipitation of tartrate crystals that are then removed, thereby eliminating the excess ions that cause instability in wine. Another approach to tartaric stabilization is using enological stabilizers with a colloid protective effect, which prevents the formation of tartrate crystals. The most commonly used tartaric stabilizers are sodium carboxymethylcellulose (CMC) and metatartaric acid. However, both have drawbacks: they are semi-synthetic products, and metatartaric acid degrades over time, losing its stabilizing effect. This study aims to compare the effects of cold stabilization, stabilization with CMC, and metatartaric acid on the chemical composition, particularly the volatilome, of white, rosé, and red wines. Cold stabilization significantly impacted the wine volatilome, especially in white and rosé wines, by decreasing total alcohols and increasing total esters. It also reduced the color intensity of rosé and red wines by lowering monomeric anthocyanins. In contrast, enological stabilizers had minimal impact on the wines’ phenolic composition, chromatic characteristics, and volatilome. The sensory impact of cold stabilization is complex; it can potentially enhance the aroma of white and rosé wines by increasing ester VOCs and decreasing higher alcohols, but it negatively affects the color of rosé and red wines.

Trendy high-density olive fields are often monovarietal orchards, mostly using the cultivar Arbequina. However, Arbequina shows a strong self-incompatibility response, and its yields depend on wind cross-pollination, which is not always available. With the aim of finding suitable self-compatible cultivars that can replace Arbequina, we evaluated pollen–pistil interaction, fruit set and seed paternity in Arbosana under different pollination treatments: self-pollination, open-pollination and three cross-pollination treatments: × Arbequina, × Sikitita and × Koroneiki. All these cultivars are low-vigor cultivars suitable for high-density orchards, making them potential pollinizers for Arbosana. The results show that Arbosana is also self-incompatible with a strong reduction in fruit set due to a lower fertilization level caused by a strong inhibition of pollen tube growth in self-pollinated flowers. Seed-paternity analyses confirmed the self-incompatibility response of Arbosana and suggest that some fruit obtained in bagged shoots under self-pollination were, in fact, a product of cross-fertilization. In conclusion, we recommend against the use of Arbosana in large monovarietal orchards. On the contrary, good results were obtained under cross-pollination with Sikitita, Arbequina and Koroneiki pollen, allowing us to recommend them as pollinizers for Arbosana in appropriate pollination designs. This is the first time Arbosana self-incompatibility has been reported.

The effects of normal (NA) and controlled atmosphere (CA) storage and postharvest treatment with 1-methylcyclopropene (1-MCP) before CA storage for 5 months on the volatilome, biochemical composition and quality of ‘Golden Delicious’ (GD) and ‘Red Delicious’ (RD) apples were studied. Apples stored under NA and CA maintained and 1-MCP treatment increased firmness in both cultivars. NA storage resulted in a decrease of glucose, sucrose and fructose levels in both cultivars. When compared to CA storage, 1-MCP treatment caused a more significant decrease in sucrose levels and an increase in glucose levels. Additionally, 1-MCP-treated apples exhibited a significant decrease in malic acid content for both cultivars. All storage conditions led to significant changes in the abundance and composition of the volatilome in both cultivars. GD and RD apples responded differently to 1-MCP treatment compared to CA storage; higher abundance of hexanoate esters and (E,E)-α-farnesene was observed in RD apples treated with 1-MCP. While 1-MCP was effective in reducing (E,E)-α-farnesene abundance in GD apples, its impact on RD apples was more limited. However, for both cultivars, all storage conditions resulted in lower levels of 2-methylbutyl acetate, butyl acetate and hexyl acetate. The effectiveness of 1-MCP is cultivar dependent, with GD showing better results than RD.

Hybrid PVT solar systems offer an innovative approach that allows solar energy to be used to simultaneously generate thermal and electrical energy. It is still a challenge to develop an energy-efficient hybrid PVT system. The aim of this work is to develop a mathematical model, investigate the system’s performance based on parameters, include sensitivity analysis in the upper layer mainly photovoltaic part, and provide an efficient and innovative system. Performance analysis of the hybrid system is obtained by establishing a mathematical model and efficiency analysis. The electrical model and thermal model of the hybrid system is also obtained by appropriate and complete mathematical modeling. It establishes a good connection of the system in the context of electrical analysis and power generation. The parameters variation impact and sensitivity analysis of the most important parameters, namely, irradiance, ambient temperature, panel temperature, wind speed, and humidity in the PV panel section, are also obtained using a MATLAB model. The results show the effective increase or decrease in the electrical power and sensitiveness in the output of the system due to this modification. Related MPP values as a result of these parameters variation and their impact on the overall output of the hybrid PVT system are also analyzed.

The instability of calcium tartrate (CaT) in wines occurs when the effective concentration of ions surpasses the solubility product, leading to the formation of CaT crystals. Unlike potassium hydrogen tartrate (KHT), temperature has little effect on the rate of CaT precipitation, making cold stabilization ineffective. Additives like metatartaric acid and carboxymethylcellulose (CMC) have been used to mitigate this problem, but metatartaric acid’s effectiveness is limited due to hydrolysis. Additionally, potassium polyaspartate (KPA), commonly used as a KHT stabilizer, has been reported to reduce wine stability regarding CaT instability. Therefore, exploring alternative stabilization methods is crucial. Alginic acid, permitted as a processing aid in winemaking, can be an alternative to CMC and metatartaric acid due to its strong negative charge and ability to bind calcium ions. This study aimed to assess alginic acid’s efficacy as a CaT stabilizer compared to CMC and investigate the impact of KPA on CaT instability. The results showed that KPA did not increase CaT instability and even improved its stability in some wines. Alginic acid outperformed both CMC and KPA in mitigating CaT instability, possibly due to its higher zeta potential and calcium ion complexation ability. This study is the first to investigate the use of alginic acid for CaT stability in wine.

Beginning in ancient times, human societies around the world continue to produce fermented beverages from locally available sugar sources [...]

Seven new abietane diterpenoids, comprising medusanthol A–G (1–3, 5, 7–9) and two previously identified analogs (4 and 6), were isolated from the hexane extract of the aerial parts of Medusantha martiusii. The structures of the compounds were elucidated by HRESIMS, 1D/2D NMR spectroscopic data, IR spectroscopy, NMR calculations with DP4+ probability analysis, and ECD calculations. The anti-neuroinflammatory potential of compounds 1–7 was evaluated by determining their ability to inhibit the production of nitric oxide (NO) and the proinflammatory cytokine TNF-α in BV2 microglia stimulated with LPS and IFN-γ. Compounds 1–4 and 7 exhibited decreased NO levels at a concentration of 12.5 µM. Compound 1 demonstrated strong activity with an IC50 of 3.12 µM, and compound 2 had an IC50 of 15.53 µM; both compounds effectively reduced NO levels compared to the positive control quercetin (IC50 11.8 µM). Additionally, both compounds significantly decreased TNF-α levels, indicating their potential as promising anti-neuroinflammatory agents.

Abstract Hashimoto thyroiditis is an autoimmune disease characterized by hypothyroidism and a high level of anti-thyroid autoantibodies. It has shown to negatively impact female fertility; however, the mechanisms are unclear. Ovarian follicular fluid appears to be the key to understanding how Hashimoto thyroiditis affecst fertility. Thus, we aimed to evaluated the metabolic profile of follicular fluid and antithyroid autoantibody levels in the context of Hashimoto thyroiditis. We collected follicular fluid from 61 patients, namely 38 women with thyroid autoantibody positivity and 23 women as negative controls, undergoing in vitro fertilization treatment. Follicular fluid samples were analyzed using metabolomics, and thyroid autoantibodies were measured. Fifteen metabolites with higher concentrations in the follicular fluid samples from Hashimoto thyroiditis were identified, comprising five possible affected pathways: the glycerophospholipid, arachidonic acid, linoleic acid, alpha-linolenic acid, and sphingolipid metabolism pathways. These pathways are known to regulate ovarian functions. In addition, antithyroglobulin antibody concentrations in both serum and follicular fluid were more than tenfold higher in women with Hashimoto thyroiditis than in controls. Our data showed that the metabolic profile of follicular fluid is altered in women with Hashimoto thyroiditis, suggesting a potential mechanistic explanation for the association of this disease with female infertility.

Abstract Background Tumour hypoxia is a negative predictive and prognostic biomarker in colorectal cancer typically assessed by invasive sampling methods, which suffer from many shortcomings. This retrospective proof-of-principle study explores the potential of MRI-derived imaging markers in predicting tumour hypoxia non-invasively in patients with colorectal liver metastases (CLM). Methods A single-centre cohort of 146 CLMs from 112 patients were segmented on preoperative T2-weighted (T2W) images and diffusion-weighted imaging (DWI). HIF-1 alpha immunohistochemical staining index (high/low) was used as a reference standard. Radiomic features were extracted, and machine learning approaches were implemented to predict the degree of histopathological tumour hypoxia. Results Radiomic signatures from DWI b200 (AUC = 0.79, 95% CI 0.61–0.93, p = 0.002) and ADC (AUC = 0.72, 95% CI 0.50–0.90, p = 0.019) were significantly predictive of tumour hypoxia. Morphological T2W TE75 (AUC = 0.64, 95% CI 0.42–0.82, p = 0.092) and functional DWI b0 (AUC = 0.66, 95% CI 0.46–0.84, p = 0.069) and b800 (AUC = 0.64, 95% CI 0.44–0.82, p = 0.071) images also provided predictive information. T2W TE300 (AUC = 0.57, 95% CI 0.33–0.78, p = 0.312) and b = 10 (AUC = 0.53, 95% CI 0.33–0.74, p = 0.415) images were not predictive of tumour hypoxia. Conclusions T2W and DWI sequences encode information predictive of tumour hypoxia. Prospective multicentre studies could help develop and validate robust non-invasive hypoxia-detection algorithms. Critical relevance statement Hypoxia is a negative prognostic biomarker in colorectal cancer. Hypoxia is usually assessed by invasive sampling methods. This proof-of-principle retrospective study explores the role of AI-based MRI-derived imaging biomarkers in non-invasively predicting tumour hypoxia in patients with colorectal liver metastases (CLM). Graphical Abstract

Introduction: One hundred thirty million Chlamydia trachomatis infections are reported worldwide each year. Nineteen serotypes of this pathogen can cause infection in pregnant women and neonates. The distribution of these genotypes in newborns with respiratory infections in Mexico is unknown. Material and methods: We tested 1062 bronchial lavage samples from neonates with respiratory distress syndrome for Chlamydia infection. The diagnosis of Chlamydia was made by plasmid detection with an in-house PCR assay, and genotypes were identified using a PCR-RFLP assay for the ompA gene. Results: The genotyping of 40 strains identified 14 as I/Ia (35%), 13 as E (32.5%), 7 as D (17.5%), 5 as F (12.5%), and 1 as L2 (2.5%). The relative risk analysis showed that genotype D was associated with neonatal sepsis (RR, 5.83; 95% confidence interval [CI], 1.51–25.985; P

Objective. To determine whether there is an association between subclinical hypothyroidism and glycemic control in older adults who received care at the “Centro Médico Naval” from 2010 to 2015. Methods. This retrospective analytical study analyzed a secondary database of the care of elderly in the study hospital. The sample was comprised of 1,385 older adults. To detect an association between variables, the Poisson regression with robust variance was used at a significance level of 95%. The analyses were carried out with the STATA 16 program. Results. Of the elderly 45.6% were between 71 and 80 years old; 58.4% were women and 43.8% had a normal body mass index. There was evidence of inadequate glycemic control in 8.1% and subclinical hypothyroidism in 15.2% of the elderly patients. Subclinical hypothyroidism was more frequent in the inadequate glycemic control vs. adequate glycemic control populations (41.1% vs. 13.0%). In the multivariance analysis, subclinical hypothyroidism (aPR = 2.22 95% CI [1.47–3.36]) was independent factor associated with inadequate glycemic control (p

Importantes conceitos de gnosiologia e ontologia na Sagrada Escritura são incompatíveis com não poucas idéias no pensamento gentitico antigo, assim como, com parte substancial do pensamento filosófico na era cristã tributário da filosofia grega. Entretanto essas idéias bíblicas podem ser encontradas em concepções epistemotõgicas e ontolôgicas da$sica moderna. Exemplos: opacidade da realidade e impotência dos sentidos, matematização universal, unicidade da matéria, realidade do espaço e do tempo, substanciatidade da luz, existência do vácuo, não existência dos cinco elementos, etc.