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1. The Transcriptomic Portrait of Locally Advanced Breast Cancer and Its Prognostic Value in a Multi-Country Cohort of Latin American Patients

Author

Andrea Sabina Llera, Eliana Saul Furquim Werneck Abdelhay, Nora Artagaveytia, Adrián Daneri-Navarro, Bettina Müller, Carlos Velazquez, Elsa B. Alcoba, Isabel Alonso, Daniela B. Alves da Quinta, Renata Binato, Alicia Inés Bravo, Natalia Camejo, Dirce Maria Carraro, Mónica Castro, Juan M. Castro-Cervantes, Sandra Cataldi, Alfonso Cayota, Mauricio Cerda, Alicia Colombo, Susanne Crocamo, Alicia Del Toro-Arreola, Raúl Delgadillo-Cisterna, Lucía Delgado, Marisa Dreyer-Breitenbach, Laura Fejerman, Elmer A. Fernández, Jorge Fernández, Wanda Fernández, Ramón A. Franco-Topete, Carolina Gabay, Fancy Gaete, Adriana Garibay-Escobar, Jorge Gómez, Gonzalo Greif, Thomas G. Gross, Marisol Guerrero, Marianne K. Henderson, Miguel E. Lopez-Muñoz, Alejandra Lopez-Vazquez, Silvina Maldonado, Andrés J. Morán-Mendoza, Maria Aparecida Nagai, Antonio Oceguera-Villanueva, Miguel A. Ortiz-Martínez, Jael Quintero, Antonio Quintero-Ramos, Rui M. Reis, Javier Retamales, Ernesto Rivera-Claisse, Darío Rocha, Robinson Rodríguez, Cristina Rosales, Efrain Salas-González, Verónica Sanchotena, Laura Segovia, Juan Martín Sendoya, Aida A. Silva-García, Alejandra Trinchero, Olivia Valenzuela, Vidya Vedham, Livia Zagame, United States-Latin American Cancer Research Network (US-LACRN), Osvaldo L. Podhajcer, Juan Abarca, Pamela Acevedo, Graciela Acosta, Gissel Acosta, Gabriela Acosta Haab, Ana Lilian Acosta Silva, Marta Aghazarian, Carola Aguayo, Bernardo Aizen, Gustavo Alarcon Lopez, Liz Almeida, Ana Alvarez, Viviane Andrade, Wenceslao Angeles-Bueno, Roberto Arai, Priscila Elvira Arambula Barreras, Ma. Isabel Aramburo Rubio, Gonzalo Ardao, Lilia A. Arellano-Jimenez, Claudia Arias, Ricardo Armisen, Mauricio Aspee, Rodrigo Assar, Itzel Reneé Astiazarán Rascón, Sebastian Astorga, Maxwell Aviles Rodriguez, Antônio Bailão Junior, Adolfo E. Barragan-Curiel, Adelfo Barragan-Ruiz, Fernanda Bermudez, Julia Bernachin, Wilfrido Bernal Herrera, Mara Bonet, Sarah Brnich, Claudio Bustamante, Miguel Angel Bustamante, Julio Bustos-Gomez, Felipe de J Bustos-Rodriguez, Janett Caballero Jasso, Angie Calfuman, Antonio Hugo José Froes Marques, Mónica Campos, Soledad Cano, Juan C. Canton-Romero, Ricardo Cappetta, Paulina Carmona, Fernando Carrizo, André Lopes Carvalho, Erika Carvallo, Julio Carzoglio, Monica Casalnuovo, Benedicta Caserta, Alvaro Castillo, César Castillo, Roger Chammas, Mario Alberto Chavez Zamudio, Loreto Chia, Elisa Chiarello, Daniela Chirico, Esther Cisneros-Quirarter, Minor Raul Cordero Bautista, Valeria Cornejo, Baldemar Corral Villegas, Andrés Cortés, Sandra Cortés, Laura Cortes-Sanabria, German Salvador Cortez Zamorano, Alejandro Corvalan, Adolfo Cruz, Alba d'Aurora, Sandra De la Fuente, Soledad De la Peña, Roberto de Leon Caballero, Mirian de Souza, César Del Castillo, Azucena Del-Toro-Valero, Mirtha Di Pretoro, Andrea Digonzelli, Jose El Ters, Paula Escobar, Marcela Estolaza, Adriane Feijo Evangelista, Marcelo Fanelli, Paulo Farias, Graciela Fernandez, José R. Filassi, Natalia Filgueiras, Diego Flaks, Edgar G. Flores-Ayala, Maria R. Flores-Marquez, David Franco Hughes, Karina Franco-Topete, Jimena Freire, Cristobal Fresno, Romina Gabrielli, Mario Gallegos, Jorge Gamboa, Daiana Ganiewich, Carlos Garbovesky, Ruben Alejandro Garcia Munguia, Ricardo Garcia-Gaeta, Alma C. Garcia-Martinez, Liliana Gimenez, Hector Gómez Silveira, Mariana M. Gomez-Del Toro, Marcela Gonzalez, Alicia Gonzalez, Germán González, Cesar Osbaldo Gonzalez Mondaca, Leivy P. Gonzalez-Ramirez, Beatriz Gonzalez-Ulloa, Susana Gorostidy, Mariela Grass, Alfonso G. Guevara Torres, Lorena Gutierrez, Susan A. Gutierrez-Rubio, Adrián Hannois, Andrew Hart, Steffen Härtel, Marcos Henriquez, Rafael Hernandez Guevara, Miriam E. Hernandez-Franco, Manuel I. Herrera-Miramontes, Graciela Horton, Gladys Ibañez, Martín Ipiña, Beatriz Jalfin, Lilian Jara, Raul Jara, Maria Luisa Jaramillo, David Javalera-Castro, Maria Eugenia Jimenez, Hugo Ju, Nazareth Juárez Rusjan, Karen Juneman, Ligia Maria Kerr, Alejandra Krupelis, Flor Esmeralda Larios-Jimenez, Jose Domingo Latorre, Guillermo Laviña, Fernando Lavista, Irma Leticia León Duarte, Alberto Lescano, Verónica Lezano, Rossana Mendoza Lopez, Jose Guillermo Lopez Cervantes, Miguel Enrique Lopez Muñoz, Dora Loria, Alejandra Luque, Alejandro Maass, Maria do Socorro Maciel, Flavia Rotea Mangone, Jorge Mansilla, Katherine Marcelain, Carolina Mariani, Marcia Maria Chiquitelli Marques, Reyna J. Martinez-Arriaga, Hector R. Martinez-Ramirez, Marcela Martins, Alma G. Maya-Gonzalez, Brenda Mazzaferri, Yadira Medina-Mora, Mariana Menini, Silvia Míguez, Soledad Milans, Soledad Montes, Ana Verónica Morales Hernández, Giberto Morga-Villela, Carla Morong, Homero Muñoz, Ignacio Miguel Muse, Carina Mussetti, Eduardo Mussetti, Luis J. Najar-Acosta, Elisa Napolitano e Ferreira, Nancy E. Navarro-Ruiz, Cristina Noblía, João Soares Nunes, Daniela Núñez, Fabiola Núñez, Nilton Onari, Emma M. Oropeza-De Anda, David Ortega Tirado, Cynthia Aparecida Bueno de Toledo Osório, Carlos Eduardo Paiva, Paulina Peñaloza, Miguel Peredo-Navarro, David Pereira, Laura Perez Michel, Francisca Pino, Tania Pino, Natalia Pinto, Jessica Pizarro, Carlos Pressa, Enrique Ramirez, Gladys E. Ramirez-Rosales, Claudia Ramis, Maritza Ramos-Ramirez, Adela Rascon Alcantar, Silvana Ravaglio, Francois Richard, Omar Rios Méndez, Ramón Enrique Robles Zepeda, Iara Santana Rocha, Natalia Rodriguez, Vilma Rodriguez, Maria Teresa Rodriguez, Diego Rodriguez-Gonzalez, Rosemeire A Roela, Ana M Romero-Gomez, Ana M Rosales-Sandoval, Omar V Rubio-Plascencia, Florencia Russo, Gaciela Sabini, Isabel Saffie, Helena Salina Dias, Brenda Guadalupe Samaniego Soto, Julio San Martino, Benito Sanchez-Llamas, Daniel Sat-Muñoz, Mariana Savignano, Cristovam Scapulatempo Neto, Max Mano Senna, Carolina Silva, Jaime Silvera, Isabele Small, Fernando Soares, Iberê Soares, Silvana Soares dos Santos, Evandro Sobrosa de Mello, José Antonio Sola, Irene Sorín, Alejandra Sosa, Anabella Sosa, Claudio Sosa, Sandra Soto, Cristiano de Pádua Souza, Lucía Spangenberg, Gustavo Steffanof, Florencia Straminsky, Mónica Tapia, Raziel O. Tapia-Llanos, Geronimo M. Tavares-Macias, Guillermo Temperley, Veronica Terzieff, Vicente Teti, Javier Tognarelli, Verónica Toledo, Paulina Toro, Roberto Torres, Mariana Torres-Palomares, Rogelio Troyo-San Roman, Hernan Urbano, Nicolas Vacca, Daniel Vaimberg, María Lourdes Valencia Peña, Maria Lujan Vaselevich, Jaime Vazquez-Nares, Ezequiel Velez-Gomez, Laura N. Venegas-Godinez, Patricia Vercelli, Ricardo Verdugo, René Aloisio da Costa Vieira, Marta Vilensky, María José Villarubias, Manuel Isaac Villegas Gómez, Stella Viña, Silvia Vornetti, Anapaula Hidemi Uema Watanabe, Carlos Zamorano, Luis Zapata, and Zdenka Zlatar

Subjects
breast cancer, Latin America, PAM50 subtypes, risk of recurrence, biological pathways, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

PurposesMost molecular-based published studies on breast cancer do not adequately represent the unique and diverse genetic admixture of the Latin American population. Searching for similarities and differences in molecular pathways associated with these tumors and evaluating its impact on prognosis may help to select better therapeutic approaches.Patients and MethodsWe collected clinical, pathological, and transcriptomic data of a multi-country Latin American cohort of 1,071 stage II-III breast cancer patients of the Molecular Profile of Breast Cancer Study (MPBCS) cohort. The 5-year prognostic ability of intrinsic (transcriptomic-based) PAM50 and immunohistochemical classifications, both at the cancer-specific (OSC) and disease-free survival (DFS) stages, was compared. Pathway analyses (GSEA, GSVA and MetaCore) were performed to explore differences among intrinsic subtypes.ResultsPAM50 classification of the MPBCS cohort defined 42·6% of tumors as LumA, 21·3% as LumB, 13·3% as HER2E and 16·6% as Basal. Both OSC and DFS for LumA tumors were significantly better than for other subtypes, while Basal tumors had the worst prognosis. While the prognostic power of traditional subtypes calculated with hormone receptors (HR), HER2 and Ki67 determinations showed an acceptable performance, PAM50-derived risk of recurrence best discriminated low, intermediate and high-risk groups. Transcriptomic pathway analysis showed high proliferation (i.e. cell cycle control and DNA damage repair) associated with LumB, HER2E and Basal tumors, and a strong dependency on the estrogen pathway for LumA. Terms related to both innate and adaptive immune responses were seen predominantly upregulated in Basal tumors, and, to a lesser extent, in HER2E, with respect to LumA and B tumors.ConclusionsThis is the first study that assesses molecular features at the transcriptomic level in a multicountry Latin American breast cancer patient cohort. Hormone-related and proliferation pathways that predominate in PAM50 and other breast cancer molecular classifications are also the main tumor-driving mechanisms in this cohort and have prognostic power. The immune-related features seen in the most aggressive subtypes may pave the way for therapeutic approaches not yet disseminated in Latin America.Clinical Trial RegistrationClinicalTrials.gov (Identifier: NCT02326857).

Published
2022
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2. Socioeconomic, Clinical, and Molecular Features of Breast Cancer Influence Overall Survival of Latin American Women

Author

Liz Maria de Almeida, Sandra Cortés, Marta Vilensky, Olivia Valenzuela, Laura Cortes-Sanabria, Mirian de Souza, Rafael Alonso Barbeito, Eliana Abdelhay, Nora Artagaveytia, Adrian Daneri-Navarro, Andrea S. Llera, Bettina Müller, Osvaldo L. Podhajcer, Carlos Velazquez, Elsa Alcoba, Isabel Alonso, Alicia I. Bravo, Natalia Camejo, Dirce Maria Carraro, Mónica Castro, Sandra Cataldi, Alfonso Cayota, Mauricio Cerda, Alicia Colombo, Susanne Crocamo, Alicia Del Toro-Arreola, Raul Delgadillo-Cristerna, Lucia Delgado, Marisa Dreyer Breitenbach, Elmer Fernández, Jorge Fernández, Wanda Fernández, Ramon A. Franco-Topete, Fancy Gaete, Jorge Gómez, Leivy P. Gonzalez-Ramirez, Marisol Guerrero, Susan A. Gutierrez-Rubio, Beatriz Jalfin, Alejandra Lopez-Vazquez, Dora Loria, Silvia Míguez, Andres de J. Moran-Mendoza, Gilberto Morgan-Villela, Carina Mussetti, Maria Aparecida Nagai, Antonio Oceguera-Villanueva, Rui M. Reis, Javier Retamales, Robinson Rodriguez, Cristina Rosales, Efrain Salas-Gonzalez, Laura Segovia, Juan M. Sendoya, Aida A. Silva-Garcia, Stella Viña, Livia Zagame, Beth Jones, Moysés Szklo, United States-Latin American Cancer Research Network (US-LACRN), Juan Abarca, Pamela Acevedo, Graciela Acosta, Ana Acosta, Gabriela Acosta Haab, Keyla Teresa Acosta-Torres, Marta Aghazarian, Carola Aguayo, Gustavo Alarcon-Lopez, Viviane Andrade, Wenceslao Angeles Bueno, Roberto Arai, Priscila Elvira Arambula-Barreras, Maria Isabel Arámburo-Rubio, Estrellita Araus, Gonzalo Ardao, Lilia A. Arellano-Jimenez, Felipe Argandoña, Claudia Arias, Ricardo Armisen, Mauricio Aspee, Rodrigo Assar, Itzel Reneé Astiazarán-Rascón, Sebastian Astorga, Maxwell Avilés-Rodrıguez, Antônio Bailão Junior, Adolfo E. Barragan-Curiel, Adelfo Barragan-Ruiz, Julia Bernachin, Wilfrido Bernal-Herrera, Renata Binato, Sarah Brnich, Claudio Bustamante, Miguel Angel Bustamante, Julio Bustos Gomez, Felipe de J. Bustos Rodriguez, Janett Caballero-Jasso, Angie Calfuman, Antonio Hugo, José Froes Marques Campos, Mónica Campos, Soledad Cano, Juan C. Canton-Romero, Paulina Carmona, Fernando Carrizo, Andre Lopes Carvalho, Erika Carvallo, Julio Carzoglio, Monica Casalnuovo, Benedicta Caserta, Alvaro Castillo, César Castillo, Juan M. Castro-Cervantes, Yascara Cerda, Roger Chammas, Mario Alberto Chavez-Zamudio, Loreto Chia, Daniela Chirico, Esther Cisneros-Quirarter, Minor Raul Cordero-Bautista, Valeria Cornejo, Baldemar Corral-Villegas, Andrés Cortés, German Salvador Cortez-Zamorano, Alejandro Corvalan, Adolfo Cruz, Alba d’Aurora, Sandra De la Fuente, Soledad De la Peña, Roberto de Leon-Caballero, César Del Castillo, Azucena Del-Toro-Valero, Mirtha Di Pretoro, Andrea Digonzelli, Jose El Ters, Paula Escobar, Marcela Estolaza, Adriane Feijo Evangelista, Marcelo Fanelli, Paulo Farias, Diego Flaks, Edgar G. Flores-Ayala, Maria R. Flores-Marquez, David Franco-Hughes, Karina Franco-Topete, Cristobal Fresno, Carolina Gabay, Mario Gallegos, Jorge Gamboa, Daiana Ganiewich, Carlos Garbovesky, Ricardo Garcia-Gaeta, Alma C. Garcia-Martinez, Rubén Alejandro Garcıa-Munguıa, Adriana Garibay-Escobar, Liliana Gimenez, Mariana M. Gomez-Del Toro, Germán González, César Osbaldo González Mondaca, Beatriz Gonzalez-Ulloa, Susana Gorostidy, Gonzalo Greif, Alfonso G. Guevara-Torres, Lorena Gutierrez, Adrián Hannois, Andrew Hart, Steffen Härtel, Marcos Henriquez, Miriam E Hernandez-Franco, Rafael Hernandez-Guevara, Manuel I Herrera-Miramontes, Graciela Horton, Gladys Ibañez, Martın Ipiña, Lilian Jara, Raul Jara, Maria Luisa Jaramillo, Beatriz Jardim, Maria Eugenia Jimenez, Victor M. Jimenez-Moreno, Hugo Ju, Nazareth Juárez Rusjan, Karen Juneman, Ligia Maria Kerr, Alejandra Krupelis, Guillermo Laviña, Fernando Lavista, Irma Leticia León-Duarte, Alberto Lescano, Verónica Lezano, Rossana Mendoza Lopez, Jose Guillermo López-Cervantes, Miguel Enrique Lopez-Muñoz, Francisca Lucena, Alejandra Luque, Alejandro Maass, Maria do Socorro Maciel, Silvina Maldonado, Flavia Rotea Mangone, Jorge Mansilla, Katherine Marcelain, Carolina Mariani, Marcia Maria Chiquitelli Marques, Reyna J Martinez-Arriaga, Hector R Martinez-Ramirez, Marcela Martins, Alma G Maya-Gonzalez, Mariana Menini, Soledad Milans, Soledad Montes, Ana Verónica Morales Hernández, Carla Morong, Eduardo Mussetti, Luis J Najar-Acosta, Elisa Napolitano e Ferreira, Nancy E Navarro Ruiz, Cristina Noblıa, João Soares Nunes, Fabiola Núñez, Nilton Onari, Emma M Oropeza-De Anda, David Ortega-Tirado, Miguel Angel Ortiz-Martinez, Cynthia Aparecida Bueno de Toledo Osório, Carlos Eduardo Paiva, Paulina Peñaloza, Miguel Peredo Navarro, David Pereira, Laura Perez-Michel, Francisca Pino, Tania Pino, Natalia Pinto, Jessica Pizarro, Jael Quintero, Antonio Quintero-Ramos, Enrique Ramirez, Gladys E Ramirez-Rosales, Claudia Ramis, Maritza Ramos Ramirez, Adela Rascon-Alcantar, Francois Richard, Omar Rios-Méndez, Ernesto Rivera-Claisse, Ramón E. Robles-Zepeda, Iara Santana Rocha, Natalia Rodriguez, Vilma Rodriguez, Maria Teresa Rodriguez, Diego Rodriguez-Gonzalez, Rosemeire A Roela, Ana M. Romero-Gomez, Ana M. Rosales-Sandoval, Lidia A. Rubio-Chavez, Omar V. Rubio-Plascencia, Florencia Russo, Gaciela Sabini, Isabel Saffie, Brenda Samaniego, Benito Sanchez-Llamas, Verónica Sanchotena, Daniel Sat-Muñoz, Mariana Savignano, Cristovam Scapulatempo Neto, Max Mano Senna, Carolina Silva, Jaime Silvera, Isabele Small, Fernando Soares, Iberê Soares, Silvana Soares dos Santos, Evandro Sobrosa de Mello, José Antonio Sola, Irene Sorın, Alejandra Sosa, Claudio Sosa, Cristiano de Pádua Souza, Lucıa Spangenberg, Gustavo Steffanof, Florencia Straminsky, Mónica Tapia, Raziel O. Tapia-Llanos, Geronimo M. Tavares-Macias, Veronica Terzieff, Vicente Teti, Javier Tognarelli, Verónica Toledo, Paulina Toro, Roberto Torres, Mariana Torres-Palomares, Alejandra Trinchero, Rogelio Troyo-San Roman, Hernan Urbano, Nicolas Vacca, Marıa Lourdes Valencia-Peña, Jaime Vazquez Nares, Ezequiel Velez-Gomez, Laura N. Venegas-Godinez, Ricardo Verdugo, René Aloisio da Costa Vieira, Manuel Isaac Villegas-Gómez, Silvia Vornetti, Anapaula H. U. Watanabe, Carlos Zamorano, Luis Zapata, and Zdenka Zlatar

Subjects
global excellence, oncology, Latin America, breast cancer, molecular subtypes, risk factors, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Molecular profile of breast cancer in Latin-American women was studied in five countries: Argentina, Brazil, Chile, Mexico, and Uruguay. Data about socioeconomic characteristics, risk factors, prognostic factors, and molecular subtypes were described, and the 60-month overall cumulative survival probabilities (OS) were estimated. From 2011 to 2013, 1,300 eligible Latin-American women 18 years or older, with a diagnosis of breast cancer in clinical stage II or III, and performance status ≦̸1 were invited to participate in a prospective cohort study. Face-to-face interviews were conducted, and clinical and outcome data, including death, were extracted from medical records. Unadjusted associations were evaluated by Chi-squared and Fisher’s exact tests and the OS by Kaplan–Meier method. Log-rank test was used to determine differences between cumulative probability curves. Multivariable adjustment was carried out by entering potential confounders in the Cox regression model. The OS at 60 months was 83.9%. Multivariable-adjusted death hazard differences were found for women living in Argentina (2.27), Chile (1.95), and Uruguay (2.42) compared with Mexican women, for older (≥60 years) (1.84) compared with younger (≤40 years) women, for basal-like subtype (5.8), luminal B (2.43), and HER2-enriched (2.52) compared with luminal A subtype, and for tumor clinical stages IIB (1.91), IIIA (3.54), and IIIB (3.94) compared with stage IIA women. OS was associated with country of residence, PAM50 intrinsic subtype, age, and tumor stage at diagnosis. While the latter is known to be influenced by access to care, including cancer screening, timely diagnosis and treatment, including access to more effective treatment protocols, it may also influence epigenetic changes that, potentially, impact molecular subtypes. Data derived from heretofore understudied populations with unique geographic ancestry and sociocultural experiences are critical to furthering our understanding of this complexity.

Published
2022
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3. Signo del fluido facetario e inestabilidad vertebral segmentaria

Author

Pedro Luis Bazán, Marco Antonio Rosas Mendieta, Emmanuel Padini, Jorge Fernando Carrizo Becerra, Álvaro Enrique Borri, and Martín Medina

Subjects
enfermedad lumbar crónica, inestabilidad angular, inestabilidad traslacional, fluido facetario, lumbalgia, Orthopedic surgery, RD701-811
Abstract

Introducción: La enfermedad degenerativa de la columna lumbar es frecuente, pero aún existen dudas en relación con los criterios de inestabilidad. Objetivos: Analizar la relación del signo del fluido facetario lumbar como criterio de inestabilidad vertebral segmentaria. Materiales y Métodos: Pacientes con enfermedad lumbar crónica, que presentan hidrartrosis facetaria en la resonancia magnética y las radiografías de columna lumbar dinámicas. Se analizan la prevalencia del sexo, la edad, la sintomatología principal y el dolor a la extensión unilateral o bilateral. Resultados: Se evaluó a 139 pacientes (62% mujeres), con un promedio de edad de 50.8 años; el principal motivo de consulta fue lumbalgia (76%). El 65% refería dolor en extensión; el 35%, dolor unilateral y el 30%, dolor bilateral. El 14% tenía espondilolistesis de bajo grado en L4-L5 y el 7%, en L5-S1. La hidrartrosis era unilateral en el 20% y bilateral en el 80%; el nivel de hidrartrosis más frecuente era en L4-L5 (58%). El 6% tenía solo inestabilidad traslacional y el 2%, mixta. Un 8% presentaba Modic I y un 5%, Modic II. Conclusiones: La presencia de fluido facetario no es un criterio de inestabilidad vertebral segmentaria, al margen del nivel y el segmento localizado, o la presentación facetaria lumbar unilateral o bilateral.

Published
2023
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4. Utilidad de la medición de los músculos psoas y paraespinales mediante tomografía computarizada y resonancia magnética

Author

Emmanuel Padini, Pedro Luis Bazán, Álvaro Enrique Borri, Martín Medina, and Jorge Fernando Carrizo Becerra

Subjects
sarcopenia, unidades hounsfield, columna, psoas, multífidos, infiltración grasa, Orthopedic surgery, RD701-811
Abstract

Introducción: La sarcopenia está revistiendo importancia en el estudio de diferentes enfermedades para predecir la morbimortalidad en el perioperatorio. Los objetivos de este estudio fueron evaluar la eficacia de la tomografía y la resonancia en la medición de la musculatura del psoas y los paraespinales, y comparar estos índices con la edad, el sexo y la enfermedad. Materiales y Métodos: Se utilizaron las tomografías computarizadas y las resonancias magnéticas de pacientes ambulatorios. La medición de los músculos se realizó en los pedículos de L3 y L4. Resultados: El estudio incluyó 18 tomografías y 34 resonancias. El rango de edad de los pacientes era de 15 a 80 años, divididos en grupos etarios. En los promedios globales, en ambos estudios, el sexo masculino estaba por encima del promedio global. Con respecto a los rangos etarios, se observó que el primer grupo (15-29 años) tenía un mayor volumen muscular y de unidades Hounsfield en el psoas comparado con el grupo >60 años. Los pacientes que consultaron por espondilolistesis tenían menos masa muscular que aquellos con discopatías. Conclusiones: No existe diferencia entre la resonancia magnética y la tomografía computarizada en cuanto a la medición de los músculos paraespinales y psoas. Queda en evidencia que la disminución del volumen muscular es común en pacientes de mayor edad y con enfermedades que afectan el balance espinal.

Published
2023
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7. Non-invasive follicular neoplasm with papillary-like nuclear features: a challenging and infrequent entity in Argentina

Author

Melina Saban, Norma Tolaba, Ana M Orlandi, Susana Deutsch, Fabián Pitoia, Alicia Lowenstein, Maria Cristina Calabrese, Andrea Cavallo, Alejandro Iotti, Marcelo Monteros Alvi, Marcelo Nallar, Ana Jaén, Silvina Figurelli, Fernando Carrizo, Antonio Colobraro, Gabriela García Tascón, María Saccoliti, Andrea Paez De Lima, Melisa Lencioni, Inés Califano, and Carmen Cabezón

Subjects
Iodine Radioisotopes, Thyroid Cancer, Papillary, Adenocarcinoma, Follicular, Argentina, Humans, Thyroid Neoplasms, Retrospective Studies
Abstract

Purpose: Non-invasive encapsulated follicular variant of papillary thyroid cancer was reclassified as non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). These neoplasms have an extremely low malignant potential. The aim of this study was 1) to assess the prevalence of NIFTP in patients with papillary thyroid carcinoma, 2) to evaluate their outcomes and 3) to determine their molecular profile.Methods: Multicenter, descriptive, retrospective study. Patients with papillary thyroid cancer diagnosed from January 2006 to December 2016 from 11 referral centers were included. Diagnosis of NIFTP was based on criteria described by Nikiforov et al. in 2018. At least two pathologists agreed on the diagnosis. Two thousand six hundred and seventy-seven papillary thyroid cancer patients were included; 456 (17%) of them were follicular variant papillary thyroid cancer, and 30 (1.12%) fulfilled diagnostic criteria for NIFTP.Results: Each of the 30 included patients underwent a total thyroidectomy, and 50% were treated with radioiodine (median dose 100 mCi). After a median follow up of 37 months, 84% of patients had an excellent response, 3% had an indeterminate response and data was missing in the remaining 13%. No metastatic lymph nodes, distant metastases or recurrences were found. RAS mutations were detected in 4 patients (13%).Conclusion: The prevalence of NIFTP in our series is amongst the lowest reported. Excellent outcomes of patients underscore their low malignant potential. Molecular findings differ from other series, probably related to environmental or ethnic features of our population and the meticulous criteria for diagnosing NIFTP.

Published
2022
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8. SARCOMAS OF THE ORAL CAVITY: A STUDY OF A SERIES OF 22 CASES

Author

María Luisa Paparella, Patricia Masquijo Bisio, Liliana G. Olvi, and Fernando Carrizo

Subjects
Series (stratigraphy), Pathology, medicine.medical_specialty, High prevalence, business.industry, Soft tissue, medicine.disease, Oral cavity, Pathology and Forensic Medicine, Male patient, medicine, Immunohistochemistry, Radiology, Nuclear Medicine and imaging, Dentistry (miscellaneous), Surgery, Sarcoma, Oral Surgery, business, Human herpesvirus
Abstract

The study comprised 22 cases of oral sarcomas; clinical, histopathologic, and immunohistochemical features were evaluated. The studied series accounted for 0.1% of all oral-maxillofacial pathology, and 7% of all soft tissue tumors in the oral cavity; 59% (13 cases) were Kaposi sarcomas, mean age was 40 years (range 24-55 y), 85% occurred in male patients, and 54% cases involved the palate. The most prevalent microscopic variant was the solid type (60%), and all cases tested positive for human herpesvirus 8 (HHV-8). The remaining sarcomas were: leiomyosarcoma-3, fibrosarcoma-2, solid alveolar rhabdomyosarcoma-1, pleomorphic undifferentiated sarcoma-1, synovial sarcoma-1, and inflammatory myofibroblastic sarcoma-1. We herein present a series of 22 cases of oral sarcomas diagnosed at a single diagnostic center, thus contributing regional data to the few series reported in the literature. A distinctive feature of the present series is the high prevalence of Kaposi sarcoma, which in all cases was associated with HHV-8.

Published
2020
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9. Spindle basaloid squamous carcinoma of the upper aerodigestive tract: immunohistochemical and clinicopathological study of three cases

Author

Fernando Carrizo, Mario A. Luna, and Basel Altrabulsi

Subjects
Male, Nasal cavity, Pathology, medicine.medical_specialty, CD99, Laryngectomy, Pathology and Forensic Medicine, Carcinoma, Basosquamous, Hypopharyngeal Neoplasm, Monophasic Synovial Sarcoma, Biopsy, Biomarkers, Tumor, Maxilla, medicine, Carcinoma, Humans, Basaloid Squamous Cell Carcinoma, Sarcomatoid carcinoma, Aged, Maxillary Neoplasms, Hypopharyngeal Neoplasms, medicine.diagnostic_test, business.industry, General Medicine, Middle Aged, medicine.disease, Immunohistochemistry, Hypopharynx, Treatment Outcome, medicine.anatomical_structure, Radiotherapy, Adjuvant, business
Abstract

We describe the clinicopathological and immunohistochemical features of three spindle (sarcomatoid) basaloid squamous carcinomas in three men aged 73, 69, and 59 years with a history of tobacco and alcohol abuse. Two tumors were located in the hypopharynx and one was located in the nasal cavity. The three tumors have a pedunculated polypoid appearance. Histologically, they were composed of conventional basaloid squamous carcinomas with extensive malignant spindle cell proliferation, comprising more than 50% of the tumor. The sarcomatoid component demonstrated immunoreactivity with one or more epithelial markers. One case in addition expressed CD99 and Bcl-2 and was originally diagnosed as monophasic synovial sarcoma; however, a subsequent biopsy disclosed basaloid squamous cell carcinoma with sarcomatoid stroma. Two patients were treated with surgery and radiation whereas one refused therapy. The patients were alive 14 (case patient 1), 10 (case patient 2), and 8 (case patient 3) months after diagnosis. In the absence of evidence from immunohistochemical or electron microscopy studies, a polypoid malignant spindle cell tumor of a mucosal surface of the upper aerodigestive tract should be considered a sarcomatoid carcinoma until proven otherwise. The type of epithelial component would determine the subtype of sarcomatoid carcinoma.

Published
2006
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10. Thyroid transcription factor–1 expression in thyroid-like nasopharyngeal papillary adenocarcinoma: report of 2 cases

Author

Fernando Carrizo and Mario A. Luna

Subjects
Male, endocrine system, Pathology, medicine.medical_specialty, Local excision, endocrine system diseases, Thyroid Nuclear Factor 1, Thyroid Transcription Factor 1, Pathology and Forensic Medicine, Diagnosis, Differential, Biomarkers, Tumor, medicine, Humans, Child, business.industry, Keratin-7, Thyroid, Nuclear Proteins, Nasopharyngeal Neoplasms, General Medicine, medicine.disease, Immunohistochemistry, Adenocarcinoma, Papillary, medicine.anatomical_structure, Nasopharyngeal Papillary Adenocarcinoma, Keratins, Adenocarcinoma, business, Immunostaining, After treatment, Transcription Factors
Abstract

We present the cases of 2 pediatric patients with low-grade nasopharyngeal papillary adenocarcinoma with features suggestive of thyroid origin. Both cases showed strong nuclear immunoreactivity for thyroid transcription factor–1 protein and positive immunostaining for cytokeratins 7 and 19. After thyroid imaging studies, local excision was performed in both patients. The patients remain free of disease 2 and 15 years after treatment, with no evidence of lesions in the thyroid or elsewhere.

Published
2005
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11. Primary adrenal leiomyosarcoma treated by laparoscopic adrenalectomy

Author

Inés Califano, Anabella Daffinoti, Néstor Calónico, Sergio Quildrian, and Fernando Carrizo

Subjects
Leiomyosarcoma, medicine.medical_specialty, Endocrinology, Text mining, Laparoscopic adrenalectomy, business.industry, Endocrinology, Diabetes and Metabolism, Urology, medicine, medicine.disease, business, Surgery
Published
2015
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12. Pharyngeal teratocarcinosarcoma: review of the literature and report of two cases

Author

Fernando Carrizo, Keyla Pineda-Daboin, Anatonio Galvao Neto, and Mario A. Luna

Subjects
Male, Teratocarcinoma, Pathology, medicine.medical_specialty, medicine.medical_treatment, Pathology and Forensic Medicine, Fatal Outcome, Pharyngectomy, medicine, Humans, business.industry, Pharynx, Pharyngeal Neoplasms, Sarcoma, General Medicine, Sinonasal Tract, Middle Aged, medicine.disease, Radiation therapy, Pharyngeal Neoplasm, medicine.anatomical_structure, Blastoma, Immunohistochemistry, Radiotherapy, Adjuvant, Neoplasm Recurrence, Local, business
Abstract

Teratocarcinosarcomas are rare malignant neoplasms histologically characterized by the presence of benign and malignant epithelial and mesenchymal elements. They are seen almost exclusively in the sinonasal tract of men. We report two cases of teratocarcinosarcomas involving the posterior pharyngeal wall in a 55-year-old male and 60-year-old men. The tumors consisted of epithelial components including squamous, neuroendocrine, and glandular structures; neuroepithelium, and mesenchymal components with prominent rhabdomyoblastic, osteoblastic and chondroid differentiation. Immunohistochemical studies demonstrated markers characteristic of each component. The tumors were resected, and the patients received postoperative radiation therapy. One patient is alive with recurrent tumor 33 months after treatment and the other died 26 months after radiation therapy with distant metastasis.

Published
2006

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