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6. Genomic and Epigenomic Landscaping Defines New Therapeutic Targets for Adenosquamous Carcinoma of the Pancreas

Author

Lenkiewicz, Elizabeth, Malasi, Smriti, Hogenson, Tara L, Flores, Luis F, Barham, Whitney, Phillips, William J, Roesler, Alexander S, Chambers, Kendall R, Rajbhandari, Nirakar, Hayashi, Akimasa, Antal, Corina E, Downes, Michael, Grandgenett, Paul M, Hollingsworth, Michael A, Cridebring, Derek, Xiong, Yuning, Lee, Jeong-Heon, Ye, Zhenqing, Yan, Huihuang, Hernandez, Matthew C, Leiting, Jennifer L, Evans, Ronald M, Ordog, Tamas, Truty, Mark J, Borad, Mitesh J, Reya, Tannishtha, Von Hoff, Daniel D, Fernandez-Zapico, Martin E, and Barrett, Michael T

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Bioinformatics and Computational Biology, Genetics, Oncology and Carcinogenesis, Rare Diseases, Biotechnology, Cancer, Digestive Diseases, Human Genome, Pancreatic Cancer, Aetiology, 2.1 Biological and endogenous factors, Carcinoma, Adenosquamous, Carcinoma, Pancreatic Ductal, Chromatin, Epigenome, Humans, Mutation, Organoids, Pancreatic Neoplasms, Proto-Oncogene Proteins p21(ras), Receptor, Fibroblast Growth Factor, Type 1, Single-Cell Analysis, Smad4 Protein, Exome Sequencing, Oncology & Carcinogenesis, Biochemistry and cell biology, Oncology and carcinogenesis
Abstract

Adenosquamous cancer of the pancreas (ASCP) is a subtype of pancreatic cancer that has a worse prognosis and greater metastatic potential than the more common pancreatic ductal adenocarcinoma (PDAC) subtype. To distinguish the genomic landscape of ASCP and identify actionable targets for this lethal cancer, we applied DNA content flow cytometry to a series of 15 tumor samples including five patient-derived xenografts (PDX). We interrogated purified sorted tumor fractions from these samples with whole-genome copy-number variant (CNV), whole-exome sequencing, and Assay for Transposase-Accessible Chromatin using sequencing (ATAC-seq) analyses. These identified a variety of somatic genomic lesions targeting chromatin regulators in ASCP genomes that were superimposed on well-characterized genomic lesions including mutations in TP53 (87%) and KRAS (73%), amplification of MYC (47%), and homozygous deletion of CDKN2A (40%) that are common in PDACs. Furthermore, a comparison of ATAC-seq profiles of three ASCP and three PDAC genomes using flow-sorted PDX models identified genes with accessible chromatin unique to the ASCP genomes, including the lysine methyltransferase SMYD2 and the pancreatic cancer stem cell regulator RORC in all three ASCPs, and a FGFR1-ERLIN2 fusion associated with focal CNVs in both genes in a single ASCP. Finally, we demonstrate significant activity of a pan FGFR inhibitor against organoids derived from the FGFR1-ERLIN2 fusion-positive ASCP PDX model. Our results suggest that the genomic and epigenomic landscape of ASCP provide new strategies for targeting this aggressive subtype of pancreatic cancer. SIGNIFICANCE: These data provide a unique description of the ASCP genomic and epigenomic landscape and identify candidate therapeutic targets for this dismal cancer.

Published
2020

8. Estrogen receptor beta repurposes EZH2 to suppress oncogenic NFκB/p65 signaling in triple negative breast cancer

Author

Aspros, Kirsten G. M., Carter, Jodi M., Hoskin, Tanya L., Suman, Vera J., Subramaniam, Malayannan, Emch, Michael J., Ye, Zhenqing, Sun, Zhifu, Sinnwell, Jason P., Thompson, Kevin J., Tang, Xiaojia, Rodman, Esther P. B., Wang, Xiyin, Nelson, Adam W., Chernukhin, Igor, Hamdan, Feda H., Bruinsma, Elizabeth S., Carroll, Jason S., Fernandez-Zapico, Martin E., Johnsen, Steven A., Kalari, Krishna R., Huang, Haojie, Leon-Ferre, Roberto A., Couch, Fergus J., Ingle, James N., Goetz, Matthew P., and Hawse, John R.

Published
2022
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11. PFKFB3 controls acinar IP3R-mediated Ca2+ overload to regulate acute pancreatitis severity

Author

Zhang, Tan, primary, Chen, Shengchuan, additional, Li, Liang, additional, Jin, Yuepeng, additional, Liu, Siying, additional, Liu, Zhu, additional, Shi, Fengyu, additional, Xie, Lifen, additional, Guo, Panpan, additional, Cannon, Andrew C., additional, Ergashev, Akmal, additional, Yao, Haiping, additional, Huang, Chaohao, additional, Zhang, Baofu, additional, Wu, Lijun, additional, Sun, Hongwei, additional, Chen, Siming, additional, Shan, Yunfeng, additional, Yu, Zhengping, additional, Tolosa, Ezequiel J., additional, Liu, Jianghuai, additional, Fernandez-Zapico, Martin E., additional, Ma, Feng, additional, and Chen, Gang, additional

Published
2024
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14. Targeting of the Hedgehog/GLI and mTOR pathways in advanced pancreatic cancer, a phase 1 trial of Vismodegib and Sirolimus combination

Author

Carr, Ryan M., Duma, Narjust, McCleary-Wheeler, Angela L., Almada, Luciana L., Marks, David L., Graham, Rondell P., Smyrk, Thomas C., Lowe, Val, Borad, Mitesh J., Kim, George, Johnson, Geoffrey B., Allred, Jacob B., Yin, Jun, Lim, Vun-Sin, Bekaii-Saab, Tanios, Ma, Wen We, Erlichman, Charles, Adjei, Alex A., and Fernandez-Zapico, Martin E.

Published
2020
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15. Phase 1 trial of Vismodegib and Erlotinib combination in metastatic pancreatic cancer

Author

McCleary-Wheeler, Angela L., Carr, Ryan M., Palmer, Shanique R., Smyrk, Thomas C., Allred, Jacob B., Almada, Luciana L., Tolosa, Ezequiel J., Lamberti, Maria J., Marks, David L., Borad, Mitesh J., Molina, Julian R., Qi, Yingwei, Lingle, Wilma L., Grothey, Axel, Pitot, Henry C., Jatoi, Aminah, Northfelt, Donald W., Bryce, Alan H., McWilliams, Robert R., Okuno, Scott H., Haluska, Paul, Kim, George P., Colon-Otero, Gerardo, Lowe, Val J., Callstrom, Matthew R., Ma, Wen We, Bekaii-Saab, Tanios, Hung, Mien-Chie, Erlichman, Charles, and Fernandez-Zapico, Martin E.

Published
2020
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16. Supplementary Figure 2 from Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression

Author

Hasselluhn, Marie C., primary, Decker-Farrell, Amanda R., primary, Vlahos, Lukas, primary, Thomas, Dafydd H., primary, Curiel-Garcia, Alvaro, primary, Maurer, H. Carlo, primary, Wasko, Urszula N., primary, Tomassoni, Lorenzo, primary, Sastra, Stephen A., primary, Palermo, Carmine F., primary, Dalton, Tanner C., primary, Ma, Alice, primary, Li, Fangda, primary, Tolosa, Ezequiel J., primary, Hibshoosh, Hanina, primary, Fernandez-Zapico, Martin E., primary, Muir, Alexander, primary, Califano, Andrea, primary, and Olive, Kenneth P., primary

Published
2024
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17. Gemcitabine Activates Natural Killer Cells to Attenuate Pancreatic Cancer Recurrence

Author

Dawson, David W and Fernandez-Zapico, Martin E

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Nutrition and Dietetics, Antimetabolites, Antineoplastic, Cell Line, Tumor, Deoxycytidine, Drug Resistance, Neoplasm, Humans, Killer Cells, Natural, Neoplasm Recurrence, Local, Pancreatic Neoplasms, Gemcitabine, Neurosciences, Paediatrics and Reproductive Medicine, Gastroenterology & Hepatology, Clinical sciences, Nutrition and dietetics
Published
2016

18. RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis

Author

Carr, Ryan M., Vorobyev, Denis, Lasho, Terra, Marks, David L., Tolosa, Ezequiel J., Vedder, Alexis, Almada, Luciana L., Yurcheko, Andrey, Padioleau, Ismael, Alver, Bonnie, Coltro, Giacomo, Binder, Moritz, Safgren, Stephanie L., Horn, Isaac, You, Xiaona, Solary, Eric, Balasis, Maria E., Berger, Kurt, Hiebert, James, Witzig, Thomas, Buradkar, Ajinkya, Graf, Temeida, Valent, Peter, Mangaonkar, Abhishek A., Robertson, Keith D., Howard, Matthew T., Kaufmann, Scott H., Pin, Christopher, Fernandez-Zapico, Martin E., Geissler, Klaus, Droin, Nathalie, Padron, Eric, Zhang, Jing, Nikolaev, Sergey, and Patnaik, Mrinal M.

Published
2021
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21. Hedgehog Signaling Plays a Dual Role in Pancreatic Carcinogenesis

Author

Hogenson, Tara L., Olson, Rachel L. O., Fernandez-Zapico, Martin E., Urrutia, Raul A., Section Editor, Büchler, Markus W., Section Editor, Neoptolemos, John, Section Editor, Neoptolemos, John P., editor, Urrutia, Raul, editor, Abbruzzese, James L., editor, and Büchler, Markus W., editor

Published
2018
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22. ZIP4 Promotes Muscle Wasting and Cachexia in Mice With Orthotopic Pancreatic Tumors by Stimulating RAB27B-Regulated Release of Extracellular Vesicles From Cancer Cells

Author

Yang, Jingxuan, Zhang, Zicheng, Zhang, Yuqing, Ni, Xiaoling, Zhang, Guohua, Cui, Xiaobo, Liu, Mingyang, Xu, Can, Zhang, Qiang, Zhu, Huiyun, Yan, Jie, Zhu, Vivian F., Luo, Yusheng, Hagan, John P., Li, Zhaoshen, Fang, Jing, Jatoi, Aminah, Fernandez-Zapico, Martin E., Zheng, Lei, Edil, Barish H., Bronze, Michael S., Houchen, Courtney W., Li, Yi-Ping, and Li, Min

Published
2019
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23. Endoplasmic Reticulum Stress-Activated Transcription Factor ATF6α Requires the Disulfide Isomerase PDIA5 To Modulate Chemoresistance

Author

Higa, Arisa, Taouji, Said, Lhomond, Stéphanie, Jensen, Devon, Fernandez-Zapico, Martin E, Simpson, Jeremy C, Pasquet, Jean-Max, Schekman, Randy, and Chevet, Eric

Subjects
Genetics, Rare Diseases, Cancer, Biotechnology, 2.1 Biological and endogenous factors, Aetiology, Generic health relevance, Activating Transcription Factor 6, Antineoplastic Agents, Benzamides, COP-Coated Vesicles, Cell Survival, Cystine, Drug Resistance, Neoplasm, Endoplasmic Reticulum Chaperone BiP, Endoplasmic Reticulum Stress, HeLa Cells, Heat-Shock Proteins, Humans, Imatinib Mesylate, Piperazines, Protein Disulfide-Isomerases, Protein Transport, Pyrimidines, Unfolded Protein Response, Hela Cells, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

ATF6α, a membrane-anchored transcription factor from the endoplasmic reticulum (ER) that modulates the cellular response to stress as an effector of the unfolded-protein response (UPR), is a key player in the development of tumors of different origin. ATF6α activation has been linked to oncogenic transformation and tumor maintenance; however, the mechanism(s) underlying this phenomenon remains elusive. Here, using a phenotypic small interfering RNA (siRNA) screening, we identified a novel role for ATF6α in chemoresistance and defined the protein disulfide isomerase A5 (PDIA5) as necessary for ATF6α activation upon ER stress. PDIA5 contributed to disulfide bond rearrangement in ATF6α under stress conditions, thereby leading to ATF6α export from the ER and activation of its target genes. Further analysis of the mechanism demonstrated that PDIA5 promotes ATF6α packaging into coat protein complex II (COPII) vesicles and that the PDIA5/ATF6α activation loop is essential to confer chemoresistance on cancer cells. Genetic and pharmacological inhibition of the PDIA5/ATF6α axis restored sensitivity to the drug treatment. This work defines the mechanisms underlying the role of ATF6α activation in carcinogenesis and chemoresistance; furthermore, it identifies PDIA5 as a key regulator ATF6α-mediated cellular functions in cancer.

Published
2014

24. Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression

Author

Hasselluhn, Marie C., primary, Decker-Farrell, Amanda R., additional, Vlahos, Lukas, additional, Thomas, Dafydd H., additional, Curiel-Garcia, Alvaro, additional, Maurer, H. Carlo, additional, Wasko, Urszula N., additional, Tomassoni, Lorenzo, additional, Sastra, Stephen A., additional, Palermo, Carmine F., additional, Dalton, Tanner C., additional, Ma, Alice, additional, Li, Fangda, additional, Tolosa, Ezequiel J., additional, Hibshoosh, Hanina, additional, Fernandez-Zapico, Martin E., additional, Muir, Alexander, additional, Califano, Andrea, additional, and Olive, Kenneth P., additional

Published
2023
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27. Biology and prognostic impact of clonal plasmacytoid dendritic cells in chronic myelomonocytic leukemia

Author

Lucas, Nolwenn, Duchmann, Matthieu, Rameau, Philippe, Noël, Floriane, Michea, Paula, Saada, Véronique, Kosmider, Olivier, Pierron, Gérard, Fernandez-Zapico, Martin E, Howard, Matthew T., King, Rebecca L., Niyongere, Sandrine, Diop, M’boyba Khadija, Fenaux, Pierre, Itzykson, Raphael, Willekens, Christophe, Ribrag, Vincent, Fontenay, Michaela, Padron, Eric, Soumelis, Vassili, Droin, Nathalie, Patnaik, Mrinal M, and Solary, Eric

Published
2019
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29. Role of Transcription Factor KLF11 and Its Diabetes-Associated Gene Variants in Pancreatic Beta Cell Function

Author

Neve, Bernadette, Fernandez-Zapico, Martin E., Ashkenazi-Katalan, Vered, Dina, Christian, Hamid, Yasmin H., Joly, Erik, Vaillant, Emmanuel, Benmezroua, Yamina, Durand, Emmanuelle, Bakaher, Nicolas, Delannoy, Valerie, Vaxillaire, Martine, Cook, Tiffany, Dallinga-Thie, Geesje M., Jansen, Hans, Charles, Marie-Aline, Clément, Karine, Galan, Pilar, Hercberg, Serge, Helbecque, Nicole, Charpentier, Guillaume, Prentki, Marc, Hansen, Torben, Pedersen, Oluf, Urrutia, Raul, Melloul, Danielle, Froguel, Philippe, and Steiner, Donald F.

Published
2005

30. SUFU promotes GLI activity in a Hedgehog-independent manner in pancreatic cancer

Author

Paradise, Brooke D., primary, Gainullin, Vladimir G., additional, Almada, Luciana L., additional, Sigafoos, Ashley N., additional, Sen, Sandhya, additional, Vera, Renzo E., additional, Raja Arul, Glancis Luzeena, additional, Toruner, Murat, additional, Pease, David R., additional, Gonzalez, Alina L., additional, Mentucci, Fatima M., additional, Grasso, Daniel H., additional, and Fernandez-Zapico, Martin E., additional

Published
2023
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31. Supplementary Table S1 from Targeting BET Proteins Downregulates miR-33a To Promote Synergy with PIM Inhibitors in CMML

Author

Letson, Christopher T., primary, Balasis, Maria E., primary, Newman, Hannah, primary, Binder, Moritz, primary, Vedder, Alexis, primary, Kinose, Fumi, primary, Ball, Markus, primary, Kruer, Traci, primary, Quintana, Ariel, primary, Lasho, Terra L., primary, Finke, Christy M., primary, Almada, Luciana L., primary, Grants, Jennifer M., primary, Zhang, Guolin, primary, Fernandez-Zapico, Martin E., primary, Gaspar-Maia, Alexandre, primary, Lancet, Jeffrey, primary, Komrokji, Rami, primary, Haura, Eric, primary, Sallman, David A., primary, Reuther, Gary W., primary, Karsan, Aly, primary, Rix, Uwe, primary, Patnaik, Mrinal M., primary, and Padron, Eric, primary

Published
2023
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32. Supplementary Figure S2 from Targeting BET Proteins Downregulates miR-33a To Promote Synergy with PIM Inhibitors in CMML

Author

Letson, Christopher T., primary, Balasis, Maria E., primary, Newman, Hannah, primary, Binder, Moritz, primary, Vedder, Alexis, primary, Kinose, Fumi, primary, Ball, Markus, primary, Kruer, Traci, primary, Quintana, Ariel, primary, Lasho, Terra L., primary, Finke, Christy M., primary, Almada, Luciana L., primary, Grants, Jennifer M., primary, Zhang, Guolin, primary, Fernandez-Zapico, Martin E., primary, Gaspar-Maia, Alexandre, primary, Lancet, Jeffrey, primary, Komrokji, Rami, primary, Haura, Eric, primary, Sallman, David A., primary, Reuther, Gary W., primary, Karsan, Aly, primary, Rix, Uwe, primary, Patnaik, Mrinal M., primary, and Padron, Eric, primary

Published
2023
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33. Supplementary Data S1 from Targeting BET Proteins Downregulates miR-33a To Promote Synergy with PIM Inhibitors in CMML

Author

Letson, Christopher T., primary, Balasis, Maria E., primary, Newman, Hannah, primary, Binder, Moritz, primary, Vedder, Alexis, primary, Kinose, Fumi, primary, Ball, Markus, primary, Kruer, Traci, primary, Quintana, Ariel, primary, Lasho, Terra L., primary, Finke, Christy M., primary, Almada, Luciana L., primary, Grants, Jennifer M., primary, Zhang, Guolin, primary, Fernandez-Zapico, Martin E., primary, Gaspar-Maia, Alexandre, primary, Lancet, Jeffrey, primary, Komrokji, Rami, primary, Haura, Eric, primary, Sallman, David A., primary, Reuther, Gary W., primary, Karsan, Aly, primary, Rix, Uwe, primary, Patnaik, Mrinal M., primary, and Padron, Eric, primary

Published
2023
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34. Data from Targeting BET Proteins Downregulates miR-33a To Promote Synergy with PIM Inhibitors in CMML

Author

Letson, Christopher T., primary, Balasis, Maria E., primary, Newman, Hannah, primary, Binder, Moritz, primary, Vedder, Alexis, primary, Kinose, Fumi, primary, Ball, Markus, primary, Kruer, Traci, primary, Quintana, Ariel, primary, Lasho, Terra L., primary, Finke, Christy M., primary, Almada, Luciana L., primary, Grants, Jennifer M., primary, Zhang, Guolin, primary, Fernandez-Zapico, Martin E., primary, Gaspar-Maia, Alexandre, primary, Lancet, Jeffrey, primary, Komrokji, Rami, primary, Haura, Eric, primary, Sallman, David A., primary, Reuther, Gary W., primary, Karsan, Aly, primary, Rix, Uwe, primary, Patnaik, Mrinal M., primary, and Padron, Eric, primary

Published
2023
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35. Phase II Trial of Trifluridine/Tipiracil Plus Irinotecan in Patients with Advanced, Refractory Biliary Tract Carcinoma

Author

Tella, Sri Harsha, primary, Foster, Nathan, additional, Qian, Shi, additional, Nguyen, Tran, additional, Borad, Mitesh J, additional, McWilliams, Robert R, additional, Alberts, Steven R, additional, Wee Ma, Wen, additional, Chakrabarti, Sakti, additional, Fruth, Briant, additional, Wessling, Jaclynn, additional, Hartgers, Mindy, additional, Washburn, Leslie, additional, Fernandez-Zapico, Martin E, additional, Hogenson, Tara L, additional, Pitot, Henry, additional, Jin, Zhaohui, additional, and Mahipal, Amit, additional

Published
2023
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37. Targeting BET Proteins Downregulates miR-33a To Promote Synergy with PIM Inhibitors in CMML

Author

Letson, Christopher T., primary, Balasis, Maria E., additional, Newman, Hannah, additional, Binder, Moritz, additional, Vedder, Alexis, additional, Kinose, Fumi, additional, Ball, Markus, additional, Kruer, Traci, additional, Quintana, Ariel, additional, Lasho, Terra L., additional, Finke, Christy M., additional, Almada, Luciana L., additional, Grants, Jennifer M., additional, Zhang, Guolin, additional, Fernandez-Zapico, Martin E., additional, Gaspar-Maia, Alexandre, additional, Lancet, Jeffrey, additional, Komrokji, Rami, additional, Haura, Eric, additional, Sallman, David A., additional, Reuther, Gary W., additional, Karsan, Aly, additional, Rix, Uwe, additional, Patnaik, Mrinal M., additional, and Padron, Eric, additional

Published
2023
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38. Translational relevance of SOS1 targeting for KRAS ‐mutant colorectal cancer

Author

Alem, Diego, primary, Yang, Xinrui, additional, Beato, Francisca, additional, Sarcar, Bhaswati, additional, Tassielli, Alexandra F., additional, Dai, Ruifan, additional, Hogenson, Tara L., additional, Park, Margaret A., additional, Jiang, Kun, additional, Cai, Jianfeng, additional, Yuan, Yu, additional, Fernandez‐Zapico, Martin E., additional, Tan, Aik Choon, additional, Fleming, Jason B., additional, and Xie, Hao, additional

Published
2023
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39. Supplementary Figure 3 from Inflammation-Induced NFATc1–STAT3 Transcription Complex Promotes Pancreatic Cancer Initiation by KrasG12D

Author

Baumgart, Sandra, primary, Chen, Nai-Ming, primary, Siveke, Jens T., primary, König, Alexander, primary, Zhang, Jin-San, primary, Singh, Shiv K., primary, Wolf, Elmar, primary, Bartkuhn, Marek, primary, Esposito, Irene, primary, Heßmann, Elisabeth, primary, Reinecke, Johanna, primary, Nikorowitsch, Julius, primary, Brunner, Marius, primary, Singh, Garima, primary, Fernandez-Zapico, Martin E., primary, Smyrk, Thomas, primary, Bamlet, William R., primary, Eilers, Martin, primary, Neesse, Albrecht, primary, Gress, Thomas M., primary, Billadeau, Daniel D., primary, Tuveson, David, primary, Urrutia, Raul, primary, and Ellenrieder, Volker, primary

Published
2023
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40. Supplementary Figure 1 from Inflammation-Induced NFATc1–STAT3 Transcription Complex Promotes Pancreatic Cancer Initiation by KrasG12D

Author

Baumgart, Sandra, primary, Chen, Nai-Ming, primary, Siveke, Jens T., primary, König, Alexander, primary, Zhang, Jin-San, primary, Singh, Shiv K., primary, Wolf, Elmar, primary, Bartkuhn, Marek, primary, Esposito, Irene, primary, Heßmann, Elisabeth, primary, Reinecke, Johanna, primary, Nikorowitsch, Julius, primary, Brunner, Marius, primary, Singh, Garima, primary, Fernandez-Zapico, Martin E., primary, Smyrk, Thomas, primary, Bamlet, William R., primary, Eilers, Martin, primary, Neesse, Albrecht, primary, Gress, Thomas M., primary, Billadeau, Daniel D., primary, Tuveson, David, primary, Urrutia, Raul, primary, and Ellenrieder, Volker, primary

Published
2023
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41. Supplementary Figure 5 from Inflammation-Induced NFATc1–STAT3 Transcription Complex Promotes Pancreatic Cancer Initiation by KrasG12D

Author

Baumgart, Sandra, primary, Chen, Nai-Ming, primary, Siveke, Jens T., primary, König, Alexander, primary, Zhang, Jin-San, primary, Singh, Shiv K., primary, Wolf, Elmar, primary, Bartkuhn, Marek, primary, Esposito, Irene, primary, Heßmann, Elisabeth, primary, Reinecke, Johanna, primary, Nikorowitsch, Julius, primary, Brunner, Marius, primary, Singh, Garima, primary, Fernandez-Zapico, Martin E., primary, Smyrk, Thomas, primary, Bamlet, William R., primary, Eilers, Martin, primary, Neesse, Albrecht, primary, Gress, Thomas M., primary, Billadeau, Daniel D., primary, Tuveson, David, primary, Urrutia, Raul, primary, and Ellenrieder, Volker, primary

Published
2023
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42. Data from Inflammation-Induced NFATc1–STAT3 Transcription Complex Promotes Pancreatic Cancer Initiation by KrasG12D

Author

Baumgart, Sandra, primary, Chen, Nai-Ming, primary, Siveke, Jens T., primary, König, Alexander, primary, Zhang, Jin-San, primary, Singh, Shiv K., primary, Wolf, Elmar, primary, Bartkuhn, Marek, primary, Esposito, Irene, primary, Heßmann, Elisabeth, primary, Reinecke, Johanna, primary, Nikorowitsch, Julius, primary, Brunner, Marius, primary, Singh, Garima, primary, Fernandez-Zapico, Martin E., primary, Smyrk, Thomas, primary, Bamlet, William R., primary, Eilers, Martin, primary, Neesse, Albrecht, primary, Gress, Thomas M., primary, Billadeau, Daniel D., primary, Tuveson, David, primary, Urrutia, Raul, primary, and Ellenrieder, Volker, primary

Published
2023
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43. Supplementary Figure 4 from Inflammation-Induced NFATc1–STAT3 Transcription Complex Promotes Pancreatic Cancer Initiation by KrasG12D

Author

Baumgart, Sandra, primary, Chen, Nai-Ming, primary, Siveke, Jens T., primary, König, Alexander, primary, Zhang, Jin-San, primary, Singh, Shiv K., primary, Wolf, Elmar, primary, Bartkuhn, Marek, primary, Esposito, Irene, primary, Heßmann, Elisabeth, primary, Reinecke, Johanna, primary, Nikorowitsch, Julius, primary, Brunner, Marius, primary, Singh, Garima, primary, Fernandez-Zapico, Martin E., primary, Smyrk, Thomas, primary, Bamlet, William R., primary, Eilers, Martin, primary, Neesse, Albrecht, primary, Gress, Thomas M., primary, Billadeau, Daniel D., primary, Tuveson, David, primary, Urrutia, Raul, primary, and Ellenrieder, Volker, primary

Published
2023
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44. Supplementary Information from Inflammation-Induced NFATc1–STAT3 Transcription Complex Promotes Pancreatic Cancer Initiation by KrasG12D

Author

Baumgart, Sandra, primary, Chen, Nai-Ming, primary, Siveke, Jens T., primary, König, Alexander, primary, Zhang, Jin-San, primary, Singh, Shiv K., primary, Wolf, Elmar, primary, Bartkuhn, Marek, primary, Esposito, Irene, primary, Heßmann, Elisabeth, primary, Reinecke, Johanna, primary, Nikorowitsch, Julius, primary, Brunner, Marius, primary, Singh, Garima, primary, Fernandez-Zapico, Martin E., primary, Smyrk, Thomas, primary, Bamlet, William R., primary, Eilers, Martin, primary, Neesse, Albrecht, primary, Gress, Thomas M., primary, Billadeau, Daniel D., primary, Tuveson, David, primary, Urrutia, Raul, primary, and Ellenrieder, Volker, primary

Published
2023
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45. Supplementary Figure 2 from Inflammation-Induced NFATc1–STAT3 Transcription Complex Promotes Pancreatic Cancer Initiation by KrasG12D

Author

Baumgart, Sandra, primary, Chen, Nai-Ming, primary, Siveke, Jens T., primary, König, Alexander, primary, Zhang, Jin-San, primary, Singh, Shiv K., primary, Wolf, Elmar, primary, Bartkuhn, Marek, primary, Esposito, Irene, primary, Heßmann, Elisabeth, primary, Reinecke, Johanna, primary, Nikorowitsch, Julius, primary, Brunner, Marius, primary, Singh, Garima, primary, Fernandez-Zapico, Martin E., primary, Smyrk, Thomas, primary, Bamlet, William R., primary, Eilers, Martin, primary, Neesse, Albrecht, primary, Gress, Thomas M., primary, Billadeau, Daniel D., primary, Tuveson, David, primary, Urrutia, Raul, primary, and Ellenrieder, Volker, primary

Published
2023
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46. Supplementary Figure 6 from Inflammation-Induced NFATc1–STAT3 Transcription Complex Promotes Pancreatic Cancer Initiation by KrasG12D

Author

Baumgart, Sandra, primary, Chen, Nai-Ming, primary, Siveke, Jens T., primary, König, Alexander, primary, Zhang, Jin-San, primary, Singh, Shiv K., primary, Wolf, Elmar, primary, Bartkuhn, Marek, primary, Esposito, Irene, primary, Heßmann, Elisabeth, primary, Reinecke, Johanna, primary, Nikorowitsch, Julius, primary, Brunner, Marius, primary, Singh, Garima, primary, Fernandez-Zapico, Martin E., primary, Smyrk, Thomas, primary, Bamlet, William R., primary, Eilers, Martin, primary, Neesse, Albrecht, primary, Gress, Thomas M., primary, Billadeau, Daniel D., primary, Tuveson, David, primary, Urrutia, Raul, primary, and Ellenrieder, Volker, primary

Published
2023
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47. 250 A Living Library for Uveal Melanoma

Author

Dalvin, Lauren A., primary, Erickson, Samantha R., additional, Pfannkoch, Cynthia M., additional, Miley, David R., additional, Salomao, Diva R., additional, Fautsch, Michael P., additional, Markovic, Svetomir N., additional, and Fernandez-Zapico, Martin E., additional

Published
2023
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48. Figure S7 from Genomic and Epigenomic Landscaping Defines New Therapeutic Targets for Adenosquamous Carcinoma of the Pancreas

Author

Lenkiewicz, Elizabeth, primary, Malasi, Smriti, primary, Hogenson, Tara L., primary, Flores, Luis F., primary, Barham, Whitney, primary, Phillips, William J., primary, Roesler, Alexander S., primary, Chambers, Kendall R., primary, Rajbhandari, Nirakar, primary, Hayashi, Akimasa, primary, Antal, Corina E., primary, Downes, Michael, primary, Grandgenett, Paul M., primary, Hollingsworth, Michael A., primary, Cridebring, Derek, primary, Xiong, Yuning, primary, Lee, Jeong-Heon, primary, Ye, Zhenqing, primary, Yan, Huihuang, primary, Hernandez, Matthew C., primary, Leiting, Jennifer L., primary, Evans, Ronald M., primary, Ordog, Tamas, primary, Truty, Mark J., primary, Borad, Mitesh J., primary, Reya, Tannishtha, primary, Von Hoff, Daniel D., primary, Fernandez-Zapico, Martin E., primary, and Barrett, Michael T., primary

Published
2023
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49. Supplementary table 1 from ZIP4 Promotes Pancreatic Cancer Progression by Repressing ZO-1 and Claudin-1 through a ZEB1-Dependent Transcriptional Mechanism

Author

Liu, Mingyang, primary, Yang, Jingxuan, primary, Zhang, Yuqing, primary, Zhou, Zhijun, primary, Cui, Xiaobo, primary, Zhang, Liyang, primary, Fung, Kar-Ming, primary, Zheng, Wei, primary, Allard, Felicia D., primary, Yee, Eric U., primary, Ding, Kai, primary, Wu, Huanwen, primary, Liang, Zhiyong, primary, Zheng, Lei, primary, Fernandez-Zapico, Martin E., primary, Li, Yi-Ping, primary, Bronze, Michael S., primary, Morris, Katherine T., primary, Postier, Russell G., primary, Houchen, Courtney W., primary, Yang, Jing, primary, and Li, Min, primary

Published
2023
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50. Supplementary Figures Legends from Transcriptional Induction of Periostin by a Sulfatase 2–TGFβ1–SMAD Signaling Axis Mediates Tumor Angiogenesis in Hepatocellular Carcinoma

Author

Chen, Gang, primary, Nakamura, Ikuo, primary, Dhanasekaran, Renumathy, primary, Iguchi, Eriko, primary, Tolosa, Ezequiel J., primary, Romecin, Paola A., primary, Vera, Renzo E., primary, Almada, Luciana L., primary, Miamen, Alexander G., primary, Chaiteerakij, Roongruedee, primary, Zhou, Mengtao, primary, Asiedu, Michael K., primary, Moser, Catherine D., primary, Han, Shaoshan, primary, Hu, Chunling, primary, Banini, Bubu A., primary, Oseini, Abdul M., primary, Chen, Yichun, primary, Fang, Yong, primary, Yang, Dongye, primary, Shaleh, Hassan M., primary, Wang, Shaoqing, primary, Wu, Dehai, primary, Song, Tao, primary, Lee, Ju-Seog, primary, Thorgeirsson, Snorri S., primary, Chevet, Eric, primary, Shah, Vijay H., primary, Fernandez-Zapico, Martin E., primary, and Roberts, Lewis R., primary

Published
2023
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