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96 results on '"Fernandez-Teruel, Alberto"'

13. Prevalence and influence of cys407* Grm2 mutation in Hannover-derived Wistar rats: mGlu2 receptor loss links to alcohol intake, risk taking and emotional behaviour

Author

Wood, Christian M., Nicolas, Celine S., Choi, Sun-Lim, Roman, Erika, Nylander, Ingrid, Fernandez-Teruel, Alberto, Kiianmaa, Kalervo, Bienkowski, Przemyslaw, de Jong, Trynke R., Colombo, Giancarlo, Chastagnier, Denis, Wafford, Keith A., Collingridge, Graham L., Wildt, Sheryl J., Conway-Campbell, Becky L., Robinson, Emma S.J., and Lodge, David

Published
2017
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14. Neonatal handling enduringly decreases anxiety and stress responses and reduces hippocampus and amygdala volume in a genetic model of differential anxiety: Behavioral-volumetric associations in the Roman rat strains

Author

Río-Álamos, Cristóbal, Oliveras, Ignasi, Piludu, Maria Antonietta, Gerbolés, Cristina, Cañete, Toni, Blázquez, Gloria, Lope-Piedrafita, Silvia, Martínez-Membrives, Esther, Torrubia, Rafael, Tobeña, Adolf, and Fernández-Teruel, Alberto

Published
2017
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19. Acute relaxation response induced by tibetan singing bowl sounds: a randomized controlled trial

Author

Rio Alamos, Cristobal, Montefusco Siegmund, Rodrigo, Cañete, Toni, Sotomayor, Joaquín, Fernandez Teruel, Alberto, Rio Alamos, Cristobal, Montefusco Siegmund, Rodrigo, Cañete, Toni, Sotomayor, Joaquín, and Fernandez Teruel, Alberto

Abstract

The prevalence of anxiety has increased dramatically due to COVID-19, so effective preventive interventions are welcome. The main objective of our study was to compare the acute relaxation response (RR) induced by Tibetan singing bowl (TSB) sound-based treatment against progressive muscle relaxation (PMR) and a control waiting list group (CWL) in a single treatment session in an adult nonclinical anxious population. In this cross-sectional randomized control trial, 50 participants selected based on high state anxiety were randomly assigned to one of the experimental groups. Pre/post self-reported anxiety, electroencephalographic activity (EEG), and heart rate variability (HRV) were recorded at baseline (T1), minute 15 (T2), minute 30 (T3), and minute 45 (T4). The TSB group showed significant reductions in alpha power (from T2 to T4) and increased HRV (from T3 to T4) compared with the PMR and CWL groups. Moreover, TSB and PMR both showed significant reductions in self-reported anxiety compared with CWL, with this effect being more evident in the TSB group. We concluded that a single session of TSB treatment was able to induce a more evident psychological/physiological relaxation response compared with PMR and CWL. TSB could be a relevant acute intervention in stressful situations or crisis intervention and while waiting for conventional interventions.

Published
2023

20. A maturational shift in the frontal cortex synaptic transcriptional landscape underlies schizophrenia-relevant behavioural traits:A congenital rat model

Author

Sønderstrup, Marie, Batiuk, Mykhailo Y., Mantas, Panagiotis, Tapias-Espinosa, Carles, Oliveras, Ignasi, Cañete, Toni, Sampedro-Viana, Daniel, Brudek, Tomasz, Rydbirk, Rasmus, Khodosevich, Konstantin, Fernandez-Teruel, Alberto, Elfving, Betina, Aznar, Susana, Sønderstrup, Marie, Batiuk, Mykhailo Y., Mantas, Panagiotis, Tapias-Espinosa, Carles, Oliveras, Ignasi, Cañete, Toni, Sampedro-Viana, Daniel, Brudek, Tomasz, Rydbirk, Rasmus, Khodosevich, Konstantin, Fernandez-Teruel, Alberto, Elfving, Betina, and Aznar, Susana

Abstract

Disruption of brain development early in life may underlie the neurobiology behind schizophrenia. We have reported more immature synaptic spines in the frontal cortex (FC) of adult Roman High-Avoidance (RHA-I) rats, a behavioural model displaying schizophrenia-like traits. Here, we performed a whole transcriptome analysis in the FC of 4 months old male RHA-I (n=8) and its counterpart, the Roman Low-Avoidance (RLA-I) (n=8). We identified 203 significant genes with overrepresentation of genes involved in synaptic function. Next, we performed a gene set enrichment analysis (GSEA) for genes co-expressed during neurodevelopment. Gene networks were obtained by weighted gene co-expression network analysis (WGCNA) of a transcriptomic dataset containing human FC during lifespan (n=269). Out of thirty-one functional gene networks, six were significantly enriched in the RHA-I. These were differentially regulated during infancy and enriched in biological ontologies related to myelination, synaptic function, and immune response. We validated differential gene expression in a new cohort of adolescent (<=2 months old) and young-adult (>=3 months old) RHA-I and RLA-I rats. The results confirmed overexpression of Gsn, Nt5cd1, Ppp1r1b, and Slc9a3r1 in young-adult RHA-I, while Cables1, a regulator of Cdk5 phosphorylation in actin regulation and involved in synaptic plasticity and maturation, was significantly downregulated in adolescent RHA-I. This age-related expression change was also observed for presynaptic components Snap25 and Snap29. Our results show a different maturational expression profile of synaptic components in the RHA-I strain, supporting a shift in FC maturation underlying schizophrenia-like behavioural traits and adding construct validity to this strain as a neurodevelopmental model.

Published
2023

21. Fine mapping of bone structure and strength QTLs in heterogeneous stock rat

Author

Alam, Imranul, Koller, Daniel L., Cañete, Toni, Blázquez, Gloria, Mont-Cardona, Carme, López-Aumatell, Regina, Martínez-Membrives, Esther, Díaz-Morán, Sira, Tobeña, Adolf, Fernández-Teruel, Alberto, Stridh, Pernilla, Diez, Margarita, Olsson, Tomas, Johannesson, Martina, Baud, Amelie, Econs, Michael J., and Foroud, Tatiana

Published
2015
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29. Gene expression in hippocampus as a function of differential trait anxiety levels in genetically heterogeneous NIH-HS rats

Author

Díaz-Morán, Sira, Palència, Marta, Mont-Cardona, Carme, Cañete, Toni, Blázquez, Gloria, Martínez-Membrives, Esther, López-Aumatell, Regina, Sabariego, Marta, Donaire, Rocío, Morón, Ignacio, Torres, Carmen, Martínez-Conejero, José Antonio, Tobeña, Adolf, Esteban, Francisco José, and Fernández-Teruel, Alberto

Published
2013
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34. Heterogeneous stock rat: A unique animal model for mapping genes influencing bone fragility

Author

Alam, Imranul, Koller, Daniel L., Sun, Qiwei, Roeder, Ryan K., Cañete, Toni, Blázquez, Gloria, López-Aumatell, Regina, Martínez-Membrives, Esther, Vicens-Costa, Elia, Mont, Carme, Díaz, Sira, Tobeña, Adolf, Fernández-Teruel, Alberto, Whitley, Adam, Strid, Pernilla, Diez, Margarita, Johannesson, Martina, Flint, Jonathan, Econs, Michael J., Turner, Charles H., and Foroud, Tatiana

Published
2011
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45. Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine [A.sub.1] receptor

Author

Johansson, Bjorn, Halldner, Linda, Dunwiddie, Thomas V., Masino, Susan A., Poelchen, Wolfgang, Gimenez-Llort, Lydia, Escorihuela, Rosa M., Fernandez-Teruel, Alberto, Wiesenfeld-Hallin, Zsuzsanna, Xu, Xiao-Jun, Hardemark, Anna, Betsholtz, Christer, Herlenius, Eric, and Fredholm, Bertil B.

Subjects
Anxiety -- Physiological aspects, Hypoxia -- Physiological aspects, Mice -- Physiological aspects, Adenosine -- Physiological aspects, Caffeine -- Physiological aspects, Science and technology
Abstract

Caffeine is believed to act by blocking adenosine [A.sub.1] and [A.sub.2A] receptors ([A.sub.1]R, [A.sub.2A]R), indicating that some [A.sub.1] receptors are tonically activated. We generated mice with a targeted disruption of the second coding exon of the [A.sub.1]R ([A.sub.1][R.sup.-/-]). These animals bred and gained weight normally and had a normal heart rate, blood pressure, and body temperature. In most behavioral tests they were similar to [A.sub.1][R.sup.+/+] mice, but [A.sub.1][R.sup.-/-] mice showed signs of increased anxiety. Electrophysiological recordings from hippocampal slices revealed that both adenosine-mediated inhibition and theophylline-mediated augmentation of excitatory glutamatergic neurotransmission were abolished in [A.sub.1][R.sup.-/-] mice. In [A.sub.1][R.sup.+/-] mice the potency of adenosine was halved, as was the number of [A.sub.1]R. In [A.sub.1][R.sup.-/-] mice, the analgesic effect of intrathecal adenosine was lost, and thermal hyperalgesia was observed, but the analgesic effect of morphine was intact. The decrease in neuronal activity upon hypoxia was reduced both in hippocampal slices and in brainstem, and functional recovery after hypoxia was attenuated. Thus [A.sub.1]Rs do not play an essential role during development, and although they significantly influence synaptic activity, they play a nonessential role in normal physiology. However, under pathophysiological conditions, including noxious stimulation and oxygen deficiency, they are important.

Published
2001

46. A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: the NIH heterogenous stock

Author

Johannesson, Martina, Lopez-Aumatell, Regina, Stridh, Pernilla, Diez, Margarita, Tuncel, Jonatan, Blazquez, Gloria, Martinez-membrives, Esther, Canete, Toni, Vicens-Costa, Elia, Graham, Delyth, Copley, Richard R., Hernandez-Pliego, Polinka, Beyeen, Amennai D., Ockinger, Johan, Fernandez-Santamaria, Cristina, Gulko, Percio S., Brenner, Max, Tobena, Olsson, Mott, Richard, Valdar, William, Redei, Eva E., Fernandez-Teruel, Alberto, and Flint, Jonathan

Subjects
Chromosome mapping -- Analysis, Quantitative trait loci -- Analysis, Rats -- Genetic aspects, Rats -- Physiological aspects, Rattus -- Genetic aspects, Rattus -- Physiological aspects, Health
Published
2009

47. Genomes and phenomes of a population of outbred rats and its progenitors

Author

Baud, Amelie, Guryev, Victor, Hummel, Oliver, Johannesson, Martina, Hermsen, Roel, Stridh, Pernilla, Graham, Delyth, McBride, Martin W., Foroud, Tatiana, Calderari, Sophie, Diez, Margarita, Ockinger, Johan, Beyeen, Amennai D., Gillett, Alan, Abdelmagid, Nada, Guerreiro-Cacais, Andre Ortlieb, Jagodic, Maja, Tuncel, Jonatan, Norin, Ulrika, Beattie, Elisabeth, Huynh, Ngan, Miller, William H., Koller, Daniel L., Alam, Imranul, Falak, Samreen, Osborne-Pellegrin, Mary, Martinez-Membrives, Esther, Canete, Toni, Blazquez, Gloria, Vicens-Costa, Elia, Mont-Cardona, Carme, Diaz-Moran, Sira, Tobena, Adolf, Zelenika, Diana, Saar, Kathrin, Patone, Giannino, Bauerfeind, Anja, Bihoreau, Marie-Therese, Heinig, Matthias, Lee, Young-Ae, Rintisch, Carola, Schulz, Herbert, Wheeler, David A., Worley, Kim C., Muzny, Donna M., Gibbs, Richard A., Lathrop, Mark, Lansu, Nico, Toonen, Pim, Ruzius, Frans Paul, de Bruijn, Ewary, Hauser, Heidi, Adams, David J., Keane, Thomas, Atanur, Santosh s., Aitman, Tim J., Flicek, Paul, Malinauskas, Tomas, Jones, E Yvonne, Ekman, Diana, Lopez-Aumatell, Regina, Dominiczak, Anna F., Holmdahl, Rikard, Olsson, Tomas, Gauguier, Dominique, Hubner, Norbert, Fernandez-Teruel, Alberto, Cuppen, Edwin, Mott, Richard, and Flint, Jonathan

Abstract

Finding genetic variants that contribute to phenotypic variation is one of the main challenges of modern genetics. We used an outbred population of rats (Heterogeneous Stock, HS) in a combined sequence-based and genetic mapping analysis to identify sequence variants and genes contributing to complex traits of biomedical relevance. Here we describe the sequences of the eight inbred progenitors of the HS and the variants that segregate between them. We report the genotyping of 1,407 HS rats, and the collection from 2,006 rats of 195 phenotypic measures that are relevant to models of anxiety, type 2 diabetes, hypertension and osteoporosis. We make available haplotype dosages for the 1,407 genotyped rats, since genetic mapping in the HS is best carried out by reconstructing each HS chromosome as a mosaic of the progenitor genomes. Finally, we have deposited an R object that makes it easy to incorporate our sequence data into any genetic study of HS rats. Our genetic data are available for both Rnor3.4 and Rnor5.0 rat assemblies.

Published
2014

49. A quantitative trait locus influencing anxiety in the laboratory rat

Author

Fernandez-Teruel, Alberto, Gray, Jeffrey A., Escorihuela, Rosa M., Aguilar, Raul, Gimenez-Llort, Lydia, Gil, Luis, Tobena, Adolf, Nicod, Alison, Bhomra, Amarjit, Mott, Richard, Driscoll, Peter, Dawson, Gerard R., and Flint, Jonathan

Subjects
Mice -- Behavior, Mice -- Research, Mice as laboratory animals -- Research, Quantitative trait loci -- Research, Genetic research, Health
Abstract

The analysis to explore the genetic architecture of rodent behavior in a battery of animal models of anxiety is presented. This analysis was conducted to determine whether the quantitative trait loci (QTL) detected to date specifically influence fear related traits. The analysis reveals that the QTL have relevance to trait anxiety in humans also.

Published
2002

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