47 results on '"Fernandez-Navarro, Pablo"'
Search Results
2. Approximate Bayesian inference for multivariate point pattern analysis in disease mapping
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Palmi-Perales, Francisco, Gomez-Rubio, Virgilio, Lopez-Abente, Gonzalo, Ramis-Prieto, Rebeca, Sanz-Anquela, Jose Miguel, and Fernandez-Navarro, Pablo
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Statistics - Methodology - Abstract
We present a novel approach for the analysis of multivariate case-control georeferenced data using Bayesian inference in the context of disease mapping, where the spatial distribution of different types of cancers is analyzed. Extending other methodology in point pattern analysis, we propose a log-Gaussian Cox process for point pattern of cases and the controls, which accounts for risk factors, such as exposure to pollution sources, and includes a term to measure spatial residual variation. For each disease, its intensity is modeled on a baseline spatial effect (estimated from both controls and cases), a disease-specific spatial term and the effects on covariates that account for risk factors. By fitting these models the effect of the covariates on the set of cases can be assessed, and the residual spatial terms can be easily compared to detect areas of high risk not explained by the covariates. Three different types of effects to model exposure to pollution sources are considered. First of all, a fixed effect on the distance to the source. Next, smooth terms on the distance are used to model non-linear effects by means of a discrete random walk of order one and a Gaussian process in one dimension with a Mat\'ern covariance. Models are fit using the integrated nested Laplace approximation (INLA) so that the spatial terms are approximated using an approach based on solving Stochastic Partial Differential Equations (SPDE). Finally, this new framework is applied to a dataset of three different types of cancer and a set of controls from Alcal\'a de Henares (Madrid, Spain). Covariates available include the distance to several polluting industries and socioeconomic indicators. Our findings point to a possible risk increase due to the proximity to some of these industries.
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- 2019
3. Rural-urban gradients and all-cause, cardiovascular and cancer mortality in Spain using individual data
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Ayuso-Álvarez, Ana, Ortiz, Cristina, López-Cuadrado, Teresa, Rodríguez-Blázquez, Carmen, Fernández-Navarro, Pablo, González-Palacios, Javier, Damián, Javier, and Galán, Iñaki
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- 2022
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4. Genome-wide and transcriptome-wide association studies of mammographic density phenotypes reveal novel loci
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Chen, Hongjie, Fan, Shaoqi, Stone, Jennifer, Thompson, Deborah J., Douglas, Julie, Li, Shuai, Scott, Christopher, Bolla, Manjeet K., Wang, Qin, Dennis, Joe, Michailidou, Kyriaki, Li, Christopher, Peters, Ulrike, Hopper, John L., Southey, Melissa C., Nguyen-Dumont, Tu, Nguyen, Tuong L., Fasching, Peter A., Behrens, Annika, Cadby, Gemma, Murphy, Rachel A., Aronson, Kristan, Howell, Anthony, Astley, Susan, Couch, Fergus, Olson, Janet, Milne, Roger L., Giles, Graham G., Haiman, Christopher A., Maskarinec, Gertraud, Winham, Stacey, John, Esther M., Kurian, Allison, Eliassen, Heather, Andrulis, Irene, Evans, D. Gareth, Newman, William G., Hall, Per, Czene, Kamila, Swerdlow, Anthony, Jones, Michael, Pollan, Marina, Fernandez-Navarro, Pablo, McConnell, Daniel S., Kristensen, Vessela N., Rothstein, Joseph H., Wang, Pei, Habel, Laurel A., Sieh, Weiva, Dunning, Alison M., Pharoah, Paul D. P., Easton, Douglas F., Gierach, Gretchen L., Tamimi, Rulla M., Vachon, Celine M., and Lindström, Sara
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- 2022
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5. Infection fatality risk for SARS-CoV-2 in community dwelling population of Spain : nationwide seroepidemiological study
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ENE-COVID Study Group, Pastor-Barriuso, Roberto, Pérez-Gómez, Beatriz, Hernán, Miguel A, Pérez-Olmeda, Mayte, Yotti, Raquel, Oteo-Iglesias, Jesús, Sanmartín, Jose L, León-Gómez, Inmaculada, Fernández-García, Aurora, Fernández-Navarro, Pablo, Cruz, Israel, Martín, Mariano, Delgado-Sanz, Concepción, de Larrea, Nerea Fernández, Paniagua, Jose León, Muñoz-Montalvo, Juan F, Blanco, Faustino, Larrauri, Amparo, and Pollán, Marina
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- 2020
6. ENE-COVID nationwide serosurvey served to characterize asymptomatic infections and to develop a symptom-based risk score to predict COVID-19
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Pérez-Gómez, Beatriz, Pastor-Barriuso, Roberto, Pérez-Olmeda, Mayte, Hernán, Miguel A, Oteo-Iglesias, Jesús, Fernández de Larrea, Nerea, Fernández-García, Aurora, Martín, Mariano, Fernández-Navarro, Pablo, Cruz, Israel, Sanmartín, Jose L, León Paniagua, Jose, Muñoz-Montalvo, Juan F, Blanco, Faustino, Yotti, Raquel, and Pollán, Marina
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- 2021
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7. Association between physical activity and cardiovascular risk factors: Dose and sex matter
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Santos-Lozano, Alejandro, Barrán, Alberto Torres, Fernández-Navarro, Pablo, Valenzuela, Pedro L., Castillo-Garcia, Adrián, Ruilope, Luis M., Ríos Insua, David, Ordovas, José M., Ley, Victoria, and Lucia, Alejandro
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- 2021
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8. Deprivation gap in colorectal cancer survival attributable to stage at diagnosis: A population-based study in Spain
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Nuñez, Olivier, Rodríguez Barranco, Miguel, Fernández-Navarro, Pablo, Redondo Sanchez, Daniel, Luque Fernández, Miguel Ángel, Pollán Santamaría, Marina, and Sánchez, María-José
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- 2020
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9. Tracking narrative change in the context of extremism and terrorism: Adapting the Innovative Moments Coding System
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da Silva, Raquel, Fernández-Navarro, Pablo, Gonçalves, Miguel M., Rosa, Catarina, and Silva, Joana
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- 2019
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10. Distribución municipal de la incidencia de los tumores más frecuentes en un área de elevada mortalidad por cáncer
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Viñas Casasola, Manuel Jesús, Fernández Navarro, Pablo, Fajardo Rivas, María Luisa, Gurucelain Raposo, José Luis, and Alguacil Ojeda, Juan
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- 2017
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11. Comprehensive characterization of a novel, oncogenic and targetable SEPTIN6::ABL2 fusion in T-ALL
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Lahera, Antonio, Vela-Martín, Laura, López-Nieva, Pilar, Salgado, Rocío N, Rodriguez Perales, Sandra, Raul, Torres-Ruiz, López-Lorenzo, José L, Cornago, Javier, Llamas, Pilar, Fernandez-Navarro, Pablo L, Sánchez-Domínguez, Rebeca, Segovia, José C, Sastre, Isabel, Cobos-Fernández, María Á, Menéndez, Pablo, Santos, Javier, Fernández-Piqueras, José, Villa-Morales, María, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Fundación Ramón Areces, Comunidad de Madrid (España), Asociación Española Contra el Cáncer, Instituto de Salud Carlos III, Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz, Banco Santander, Fundación Asisa, and Harvard University (Estados Unidos)
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Sí
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- 2023
12. The Minimum Basic Data Set (MBDS) as a tool for cancer epidemiological surveillance
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Fernández-Navarro, Pablo, López-Abente, Gonzalo, Salido-Campos, Carmen, and Sanz-Anquela, José Miguel
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- 2016
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13. Acculturation and drug use disorders among Hispanics in the U.S.
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Blanco, Carlos, Morcillo, Carmen, Alegría, Margarita, Dedios, María Cecilia, Fernández -Navarro, Pablo, Regincos, Rosa, and Wang, Shuai
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- 2013
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14. Genetic epistasis in female suicide attempters
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Fernández-Navarro, Pablo, Vaquero-Lorenzo, Concepción, Blasco-Fontecilla, Hilario, Díaz-Hernández, Montserrat, Gratacòs, Mònica, Estivill, Xabier, Costas, Javier, Carracedo, Ángel, Fernández-Piqueras, José, Saiz-Ruiz, Jerónimo, and Baca-Garcia, Enrique
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- 2012
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15. Sistemas de Información epidemiológica para la Vigilancia de las Enfermedades Crónicas
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Fernandez-Navarro, Pablo
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Vigilancia de la salud pública ,Sistema de Información Epidemiológica sobre Mortalidad de las Principales Enfermedades Crónicas en España (SIEMEC) ,Vigilancia de las enfermedades crónicas ,Información epidemiológica ,Enfermedades crónicas ,Sistemas de Información epidemiológica ,Sistema de Información Epidemiológica del Cáncer en España (SIEC) ,Vigilancia epidemiológica - Abstract
Comunicación presentada en las II Jornada del Centro Nacional de Epidemiología - 2021. Se exponen los sistemas de información epidemiológica para vigilancia de las Enfermedades Crónicas del Centro Nacional de Epidemiología. son: Raziel, Ariadna, Informes, Atlas, tablas y diferentes Apps. El Sistema de Información Epidemiológica sobre Mortalidad de las Principales Enfermedades Crónicas en España (SIEMEC) y el Sistema de Información Epidemiológica del Cáncer en España (SIEC).
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- 2021
16. Atlas of Cancer Mortality in Portugal and Spain (2003–2012)
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Fernandez-Navarro, Pablo L, Roquette, Rita, Nuñez, Olivier, de Sousa-Uva, Mafalda, Garcia-Perez, Javier, Lopez-Abente, Gonzalo, Nunes, Baltazar, Gonzalez-Sanchez, Mario, Dinis, José, Carmona-Alferez, Rocio, Rocha Rodrigues, Jéssica, Aragones, Nuria, Bento, María José, Castello Pastor, Adela, Rego, Raúl, Lope Carvajal, Virginia, Henrique, Rui, Boldo, Elena, Pais, Ana, Fernandez de Larrea, Nerea, Bastos, Joana, Ramis, Rebeca, Carrito, Branca, Pastor-Barriuso, Roberto, Miranda, Ana, Perez-Gomez, Beatriz, Forjaz, Gonçalo, Matias Dias, Carlos, Pollan-Santamaria, Marina, Instituto de Salud Carlos III. Centro Nacional de Epidemiología (CNE). Departamento de Enfermedades Crónicas. Unidad de Epidemiología del Cáncer y Ambiental, Instituto de Salud Carlos III. Centro de Investigación Biomédica en Red - CIBERESP (Epidemiología y Salud Pública), Instituto Nacional de Saúde Doutor Ricardo Jorge. Departamento de Epidemiologia. Unidade de Investigação Epidemiológica, and Instituto de Salud Carlos III
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Enviromental health ,Neoplasias da Próstata ,Lung Neoplasms ,Esophageal Neoplasms ,Epidemiology ,España ,Breast Neoplasms ,Cáncer de Laringe ,Cáncer de Páncreas ,Stomach Neoplasms ,Saúde Ambiental ,Neoplasias Gástricas ,Epidemiología ,Leukaemia ,Leucemia ,Cáncer de Estómago ,Mortality ,Neoplasias Laríngeas ,Epidemiologia ,Laryngeal Neoplasms ,Cancer ,Neoplasias Colorretais ,Cáncer de Colón ,Portugal ,Cáncer de Próstata ,Prostatic Neoplasms ,Cáncer de Pecho ,Cáncer ,Neoplasias de la Vejiga Urinaria ,Pancreatic Neoplasms ,Urinary Bladder Neoplasms ,Spain ,Neoplasias Pulmonares ,Mortalidad ,Mortalidade ,Cáncer de Esófago ,Cáncer de Pulmón ,Câncer ,Cáncer de Vejiga ,Colorectal Neoplasms ,Neoplasias da Mama ,Neoplasias Esofágicas ,Neoplasias Pancreáticas ,Salud ambiental - Abstract
El 'Atlas of Cancer Mortality in Portugal and Spain 2003–2012', muestra la distribución espacial de la mortalidad municipal por distintos tipos cáncer para el periodo 2003-2012. Ha sido desarrollado por la Unidad de Epidemiología del Cáncer y Ambiental del Centro Nacional de Epidemiología del ISCIII, que forma parte del CIBERESP, y por el Departamento de Epidemiología del Instituto Nacional De Saúde Doutor Ricardo Jorge de Portugal. El estudio de la distribución geográfica del riesgo de fallecer por cáncer es una de las herramientas que se usan en epidemiología para generar hipótesis sobre la posible implicación de factores ambientales en el origen de los tumores. This project is partially supported by research grant from the Spanish Health Research Fund (FIS) of the National Institute of Health Carlos III (ISCIII), Spain (Project PI17CIII/00040: “Spatial distribution of municipal cancer mortality in Spain (SICAMSA)” (“Distribución Espacial de la Mortalidad municipal por CÁncer en ESpaña (DEMOCAES)”). Introduction. Methods. Results: Oesophagus (ICD-10 C15) Stomach (ICD-10 C16) Colorectal (ICD-10 C18–C21) Pancreas (ICD-10 C25) Larynx (ICD-10 C32) Lung (ICD-10 C33–C34) Female Breast (ICD-10 C50) Prostate (ICD-10 C61) Bladder (ICD-10 C67) Leukaemia (ICD-10 C91–C95) References. Annexes: Annex I and Annex II No
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- 2021
17. Differences in maternal and paternal age between Schizophrenia and other psychiatric disorders
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Lopez-Castroman, Jorge, Gómez, David Delgado, Belloso, Juan José Carballo, Fernandez-Navarro, Pablo, Perez-Rodriguez, M. Mercedes, Villamor, Ignacio Basurte, Navarrete, Francisco Ferre, Ginestar, Consuelo Morant, Currier, Dianne, Torres, Marta Reyes, Navio-Acosta, Mercedes, Saiz-Ruiz, Jerónimo, Jimenez-Arriero, Miguel Angel, and Baca-Garcia, Enrique
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- 2010
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18. Genome wide association study identifies a novel putative mammographic density locus at 1q12-q21
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Fernandez-Navarro, Pablo, González-Neira, Anna, Pita, Guillermo, Díaz-Uriarte, Ramón, Moreno, Leticia Tais, Ederra, María, Pedraz-Pingarrón, Carmen, Sánchez-Contador, Carmen, Vázquez-Carrete, Jose Antonio, Moreo, Pilar, Vidal, Carmen, Salas-Trejo, Dolores, Stone, Jennifer, Southey, Melissa C., Hopper, John L., Pérez-Gómez, Beatriz, Benitez, Javier, and Pollan, Marina
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- 2015
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19. Sistemas de Información epidemiológica para la Vigilancia de las Enfermedades Crónicas
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Fernandez-Navarro, Pablo L
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Vigilancia de la salud pública ,Sistema de Información Epidemiológica sobre Mortalidad de las Principales Enfermedades Crónicas en España (SIEMEC) ,Vigilancia de las enfermedades crónicas ,Información epidemiológica ,Enfermedades crónicas ,Sistemas de Información epidemiológica ,Sistema de Información Epidemiológica del Cáncer en España (SIEC) ,Vigilancia epidemiológica - Abstract
Comunicación presentada en las II Jornada del Centro Nacional de Epidemiología - 2021. Se exponen los sistemas de información epidemiológica para vigilancia de las Enfermedades Crónicas del Centro Nacional de Epidemiología. son: Raziel, Ariadna, Informes, Atlas, tablas y diferentes Apps. El Sistema de Información Epidemiológica sobre Mortalidad de las Principales Enfermedades Crónicas en España (SIEMEC) y el Sistema de Información Epidemiológica del Cáncer en España (SIEC).
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- 2021
20. Impact of Lockdown on COVID-19 Transmissibility During the First Pandemic Wave in Spain
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Fernandez-Navarro, Pablo L, Nuñez, Olivier, Pampaka, Despina, Mazagatos, Clara, Guerrero-Vadillo, María, Peñuelas, Marina, Larrauri, Amparo, and Gomez-Barroso, Diana
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Geography ,Pandemic ,Competing interests ,Coronavirus disease 2019 (COVID-19) ,SARS-CoV-2 ,Spain ,Homogeneous ,Public health interventions ,COVID-19 ,Transmissibility (vibration) ,COVID-19 epidemic ,Demography - Abstract
Background: The analysis of the evolution of the COVID-19 epidemic can provide evidence of the impact of measures implemented to reduce its progression. Our aim was to describe the evolution of the pandemic in the different Spanish regions and to examine the effect of the non-pharmaceutical public health interventions during the first epidemic wave on these trends. Methods: Daily incidence rates of cases were calculated at national and regional level between 31th of January and 10th of May 2020. Epidemic curves, important dates of interventions and effective reproduction number (Rt) were plotted and transmissibility parameters were calculated. To summarize the geographical heterogeneity in the evolution, regional epidemic curves have been classified into homogeneous groups using a clustering procedure. Findings: The incidence rate reached 5 cases per 100,000 on March 1 and peaked at March 20. The Rt gradually decreased after the national lockdown falling below 1 on March 24. Two homogeneous groups of epidemic curves were identified among regions, mainly differentiated by the magnitude of the daily incidence rate and the evolution of the Rt in the period prior to lockdown. However, irrespectively of the previous trend, the lockdown was followed by a steep decrease in the number of cases starting 6 days after its implementation. Interpretation: Our results confirm that the restrictive national lockdown efficiently reduced the progression of the epidemic in Spain during the first wave. This effect was similar in the two regional clusters, independent of the previous dynamics of the epidemic. Funding Statement: The study was supported by Instituto de Salud Carlos III, Spain (ISCIII) grant number COV20-008 Declaration of Interests: All authors declare no competing interests.
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- 2021
21. Conservation genetics of the short-beaked common dolphin (Delphinus delphis) in the Mediterranean Sea and in the eastern North Atlantic Ocean
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Natoli, Ada, Cañadas, Ana, Vaquero, Concepción, Politi, Elena, Fernandez-Navarro, Pablo, and Hoelzel, A. Rus
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- 2008
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22. Large-scale genotyping identifies a new locus at 22q13.2 associated with female breast size
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Li, Jingmei, Foo, Jia Nee, Schoof, Nils, Varghese, Jajini S, Fernandez-Navarro, Pablo, Gierach, Gretchen L, Quek, Swee Tian, Hartman, Mikael, Nord, Silje, Kristensen, Vessela N, Pollán, Marina, Figueroa, Jonine D, Thompson, Deborah J, Li, Yi, Khor, Chiea Chuen, Humphreys, Keith, Liu, Jianjun, Czene, Kamila, and Hall, Per
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- 2013
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23. Socioeconomic Inequalities in Colorectal Cancer Survival in Southern Spain: A Multilevel Population-Based Cohort Study
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Luque-Fernandez, Miguel Angel, Redondo-Sánchez, Daniel, Rodríguez-Barranco, Miguel, Chang-Chan, Yoe-Ling, Salamanca-Fernández, Elena, Núñez, Olivier, Fernandez-Navarro, Pablo, Pollán, Marina, Sánchez, María-José, Instituto de Salud Carlos III, Centro de Investigación Biomedica en Red - CIBER, Gobierno de Andalucía, and Instituto de Salud Carlos III - ISCIII
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multilevel ,socioeconomic inequalities ,Socioeconomic Factors ,Survival ,epidemiological methods ,population-based epidemiology ,Epidemiological Monitoring ,Multilevel Analysis ,Clinical Epidemiology ,colorectal cancer ,Colorectal Neoplasms ,survival ,Original Research - Abstract
Miguel Angel Luque-Fernandez,1– 3 Daniel Redondo-Sánchez,1,2 Miguel Rodríguez-Barranco,1,2,4 Yoe-Ling Chang-Chan,1,4 Elena Salamanca-Fernández,1,2 Olivier Núñez,2,5 Pablo Fernandez-Navarro,2,5 Marina Pollán,2,5 María-José Sánchez1,2,4,6 1Instituto de Investigación Biosanitaria de Granada, Non-Communicable Disease and Cancer Epidemiology Group, ibs.GRANADA, University of Granada, Granada, Spain; 2Biomedical Network Research Centers of Epidemiology and Public Health (CIBERESP), Madrid, Spain; 3London School of Hygiene and Tropical Medicine, Non-Communicable Disease Epidemiology, London, UK; 4Andalusian School of Public Health, Granada, Spain; 5National Centre of Epidemiology, Health Institute Carlos III (CNE-ISCIII), Madrid, Spain; 6Department of Preventive Medicine and Public Health, University of Granada, Granada, SpainCorrespondence: Miguel Angel Luque-FernandezAndalusian School of Public Health, Cuesta Del Observatorio, 4, Granada 18080, SpainEmail miguel-angel.luque@lshtm.ac.ukBackground: Colorectal cancer (CRC) is the most frequently diagnosed cancer in Spain. Socioeconomic inequalities in cancer survival are not documented in Spain. We aim to study the association of socioeconomic inequalities with overall mortality and survival among CRC patients in southern Spain.Methods: We conducted a multilevel population-based cohort study, including CRC cases for the period 2011– 2013. The study time-to-event outcome was death, and the primary exposure was CRC patients’ socioeconomic status assessed by the Spanish deprivation index at the census tract level. We used a mixed-effects flexible hazard model, including census tract as a random intercept, to derive overall survival estimates by deprivation.Results: Among 3589 CRC patients and 12,148 person-years at risk (pyr), 964 patients died before the end of the follow-up. Mortality by deprivation showed the highest mortality rate for the most deprived group (96.2 per 1000 pyr, 95% CI: 84.0– 110.2). After adjusting for sex, age, cancer stage, and the area of residence, the most deprived had a 60% higher excess mortality risk than the less deprived group (excess mortality risk ratio: 1.6, 95% CI: 1.1– 2.3).Conclusions: We found a consistent association between deprivation and CRC excess mortality and survival. The reasons behind these inequalities need further investigation in order to improve equality cancer outcomes in all social groups.Keywords: socioeconomic inequalities, colorectal cancer, survival, population-based epidemiology, epidemiological methods, multilevel
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- 2020
24. Maintenance of Attention and Pathological Gambling
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Verdura Vizcaino, Ernesto Jose, Fernandez-Navarro, Pablo, Blanco, Carlos, Ponce, Guillermo, Navio, Mercedes, Moratti, Stephan, and Rubio, Gabriel
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- 2013
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25. Association study of two polymorphisms of the serotonin-2A receptor gene and suicide attempts
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Vaquero-Lorenzo, Concepcion, Baca-Garcia, Enrique, Diaz-Hernandez, Montserrat, Perez-Rodriguez, Mercedes M., Fernandez-Navarro, Pablo, Giner, Lucas, Carballo, Juan J., Saiz-Ruiz, Jeronimo, Fernandez-Piqueras, Jose, Baldomero, Enrique Baca, de Leon, Jose, and Oquendo, Maria A.
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- 2008
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26. Analysis of matched geographical areas to study potential links between environmental exposure to oil refineries and non-Hodgkin lymphoma mortality in Spain
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Ramis Rebeca, Diggle Peter, Boldo Elena, Garcia-Perez Javier, Fernandez-Navarro Pablo, and Lopez-Abente Gonzalo
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Non-Hodgkin lymphoma ,Refinery ,Pollution ,Mortality ,Matched analysis ,Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
Abstract Background Emissions from refineries include a wide range of substances, such as chrome, lead, nickel, zinc, arsenic, cadmium, benzene, dioxins and furans, all of which are recognized by the International Agency for Research on Cancer (IARC) as carcinogens. Various studies have shown an association between non-Hodgkin lymphoma (NHL) and residence in the vicinity of industrial areas; however, evidence of specific association between refineries and residence in the vicinity has been suggested but not yet established. The aim of this study is to investigate potential links between environmental exposure to emissions from refineries and non-Hodgkin lymphoma mortality in Spain. The spatial distribution of NHL in Spain has an unusual pattern with regions some showing higher risk than others. Methods We designed an analysis of matched geographical areas to examine non-Hodgkin lymphoma mortality in the vicinity of the 10 refineries sited in Spain over the period 1997-2006. Population exposure to refineries was estimated on the basis of distance from town of residence to the facility in a 10 km buffer. We defined 10 km radius areas to perform the matching, accounting for population density, level of industrialization and socio-demographic factors of the area using principal components analysis. For the matched towns we evaluated the risk of NHL mortality associated with residence in the vicinity of the refineries and with different regions using mixed Poisson models. Then we study the residuals to assess a possible risk trend with distance. Results Relative risks (RRs) associated with exposure showed similar values for women and for men, 1.09 (0.97-1.24) and 1.12 (0.99-1.27). RRs for two regions were statistically significant: Canary Islands showed an excess of risk of 1.35 (1.05-1.72) for women and 1.50 (1.18-1.92) for men, whilst Galicia showed an excess of risk of 1.35 (1.04-1.75) for men, but not significant excess for women. Conclusions The results suggest a possible increased risk of NHL mortality among populations residing in the vicinity of refineries; however, a potential distance trend has not been shown. Regional effects in the Canary Islands and Galicia are significantly greater than the regional average.
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- 2012
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27. ATA homozigosity in the IL-10 gene promoter is a risk factor for schizophrenia in Spanish females: a case control study
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Fernandez-Piqueras Jose, Baca-García Enrique, Fernandez-Navarro Pablo, Lopez-Rodriguez Rosario, Dorado Pedro, Lopez-Castroman Jorge, Riveiro-Alvarez Rosa, Almoguera Berta, Dal-Ré Rafael, Abad-Santos Francisco, LLerena Adrián, and Ayuso Carmen
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Internal medicine ,RC31-1245 ,Genetics ,QH426-470 - Abstract
Abstract Background Three IL-10 gene promoter single nucleotide polymorphisms -1082G > A, -819C > T and -592C > A and the haplotypes they define in Caucasians, GCC, ACC, ATA, associated with different IL-10 production rates, have been linked to schizophrenia in some populations with conflicting results. On the basis of the evidence of the sex-dependent effect of certain genes in many complex diseases, we conducted a sex-stratified case-control association study to verify the linkage of the IL-10 gene promoter SNPs and haplotypes with schizophrenia and the possible sex-specific genetic effect in a Spanish schizophrenic population. Methods 241 DSM-IV diagnosed Spanish schizophrenic patients and 435 ethnically matched controls were genotyped for -1082G > A and -592C > A SNPs. Chi squared tests were performed to assess for genetic association of alleles, genotypes and haplotypes with the disease. Results The -1082A allele (p = 0.027), A/A (p = 0.008) and ATA/ATA (p = 0.003) genotypes were significantly associated with schizophrenia in females while neither allelic nor genotypic frequencies reached statistical significance in the male population. Conclusions Our results highlight the hypothesis of an imbalance towards an inflammatory syndrome as the immune abnormality of schizophrenia. Anyway, a better understanding of the involvement of the immune system would imply the search of immune abnormalities in endophenotypes in whose sex and ethnicity might be differential factors. It also reinforces the need of performing complex gene studies based on multiple cytokine SNPs, including anti and pro-inflammatory, to clarify the immune system abnormalities direction in the etiology of schizophrenia.
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- 2011
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28. Risk Model for Prostate Cancer Using Environmental and Genetic Factors in the Spanish Multi-Case- Control (MCC) Study
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Gomez-Acebo, Ines, Dierssen Sotos, Trinidad, Fernandez Navarro, Pablo, Palazuelos, Camilo, Morros, Rosa, Aragonés, Nuria, Castaño-Vinyals, Gemma, Jiménez Monleón, Jose J., Ruiz Cerdá, Jose Luis, Pérez-Gómez, Beatriz, Ruiz-Dominguez, José Manuel, Alonso Molero, Jessica, Pollán, Marina, Kogevinas, M., Llorca, Javier, Universitat Autònoma de Barcelona, Instituto de Salud Carlos III, Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Fundación Marqués de Valdecilla, Junta de Castilla y León (España), Regional Government of Andalusia (España), Generalitat Valenciana (España), Fundación La Caixa, Basque Government (España), Gobierno de la Región de Murcia (España), Unión Europea. Comisión Europea, Asociación Española Contra el Cáncer, Government of Catalonia (España), Fundación Caja de Ahorros de Asturias, University of Oviedo (España), Universidad de Cantabria, and Universitat de Barcelona
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0301 basic medicine ,Male ,Epidemiology ,Logistic regression ,computer.software_genre ,Decile ,Prostate cancer ,0302 clinical medicine ,Human genetics ,Risk Factors ,Medicine ,Family history ,Natural environment ,Pròstata -- Càncer ,Aged, 80 and over ,Multidisciplinary ,Genètica humana ,Factors de risc en les malalties ,Men ,Middle Aged ,030220 oncology & carcinogenesis ,Data mining ,Adult ,medicine.medical_specialty ,Genotype ,Risk factors in diseases ,Science ,Medi ambient ,Single-nucleotide polymorphism ,Polymorphism, Single Nucleotide ,Article ,03 medical and health sciences ,Young Adult ,Genetic predisposition ,Genetics ,Humans ,Genetic Predisposition to Disease ,Espanya ,Epidemiologia ,Aged ,Models, Statistical ,Càncer de pròstata ,business.industry ,Cancer ,Prostatic Neoplasms ,Environmental Exposure ,medicine.disease ,030104 developmental biology ,Homes ,ROC Curve ,Spain ,business ,computer ,Genètica ,Demography - Abstract
Prostate cancer (PCa) is the second most common cancer among men worldwide. Its etiology remains largely unknown compared to other common cancers. We have developed a risk stratification model combining environmental factors with family history and genetic susceptibility. 818 PCa cases and 1,006 healthy controls were compared. Subjects were interviewed on major lifestyle factors and family history. Fifty-six PCa susceptibility SNPs were genotyped. Risk models based on logistic regression were developed to combine environmental factors, family history and a genetic risk score. In the whole model, compared with subjects with low risk (reference category, decile 1), those carrying an intermediate risk (decile 5) had a 265% increase in PCa risk (OR = 3.65, 95% CI 2.26 to 5.91). The genetic risk score had an area under the ROC curve (AUROC) of 0.66 (95% CI 0.63 to 0.68). When adding the environmental score and family history to the genetic risk score, the AUROC increased by 0.05, reaching 0.71 (95% CI 0.69 to 0.74). Genetic susceptibility has a stronger risk value of the prediction that modifiable risk factors. While the added value of each SNP is small, the combination of 56 SNPs adds to the predictive ability of the risk model. Biological samples were stored at the biobanks supported by Instituto de Salud Carlos III- FEDER: Parc de Salut MAR Biobank (MARBiobanc) (), ‘Biobanco La Fe’ () and FISABIO Biobank (), as well as at the Public Health Laboratory of Gipuzkoa, the Basque Biobank, the ICOBIOBANC (sponsored by the Catalan Institute of Oncology), the IUOPA Biobank of the University of Oviedo, and the ISCIII Biobank. SNP genotyping services were provided by the Spanish ‘Centro Nacional de Genotipado’ (CEGEN-ISCIII). We thank all the subjects who participated in the study and all MCC-Spain collaborators. This work was supported by the ‘Acción Transversal del Cancer’, approved by the Spanish Ministry Council on the 11th October 2007, by the Instituto de Salud Carlos III, co-founded by FEDER funds –‘a way to build Europe’ (grants , , , , , , , , , , ,, , , , , , , , , and ). Support was also provided by the Fundación Marqués de Valdecilla (grant ); the Junta de Castilla y León (grant ); the Consejería de Salud of the Junta de Andalucía (); the Conselleria de Sanitat of the Generalitat Valenciana (grant ); the Recercaixa (grant ); the Regional Government of the Basque Country; the Consejería de Sanidad de la Región de Murcia; European Commission grants ; the Spanish Association Against Cancer (AECC) Scientific Foundation; the Catalan Government DURSI (grant ); the Fundación Caja de Ahorros de Asturias; the University of Oviedo; Societat Catalana de Digestologia; and COST action Eucolongene. The authors thank the “Bioinformatics and Research Group in Genetic and Environmental Epidemiology” (BRG-GEE) of the Cancer and Environmental Epidemiology Unit in III Institute of Health (ISCIII), Spain, for their technical scientific support (Group consisting of Pablo Fernández-Navarro (group leader), Mario González-Sánchez (bioinformatic), Javier González-Palacios (bioinformatic)). Sí
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- 2017
29. Leisure-time physical activity and prevalence of non-communicable pathologies and prescription medication in Spain
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Fernandez-Navarro, Pablo, primary, Aragones, María Teresa, additional, and Ley, Victoria, additional
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- 2018
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30. Epidemiological situation of breast cancer in spain
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Pollan-Santamaria, Marina, Garcia Mendizabal, Maria Jose, Perez-Gomez, Beatriz, Aragones, Nuria, Lope, Virginia, Pastor-Barriuso, Roberto, Ramis, Rebeca, Fernandez-Navarro, Pablo, Garcia-Perez, Javier, Vidal, Enric, Boldo, Elena, Pérdomo, Sandra, and Lopez-Abente, Gonzalo
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supervivencia ,Supervivencia ,Survival ,Incidence ,España ,lcsh:BF1-990 ,Distribución geográfica ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,cáncer de mama ,lcsh:RC254-282 ,incidencia ,breast cancer ,lcsh:Psychology ,Cáncer de mama ,distribución geográfica ,Spain ,Mortalidad ,mortalidad ,Mortality ,Incidencia ,geographical pattern - Abstract
Title and summary, also in English. El cáncer de mama es el tumor más frecuente en Europa. Según la Agencia Internacional de Investigación del Cáncer, en 2006 se diagnosticaron unos 429.900 casos nuevos de cáncer de mama en Europa, con una tasa estandarizada de incidencia de 110 casos por 100.000 mujeres. También es la localización más frecuente en mujeres españolas: supone casi la cuarta parte de los casos de cáncer femeninos, y su incidencia está aumentando entre un 2-3% anual. Entre las posibles causas de este incremento están los cambios en los patrones reproductivos y en los hábitos de vida y la introducción de la terapia hormonal sustitutiva. Nuestro país, con una tasa de incidencia estandarizada estimada de 93,6 casos por 100.000 mujeres-año para 2006, ocupa una posición intermedia entre los países de Europa occidental y los del este. Es también una importante causa de mortalidad femenina. En 2005 causó la muerte de 5.703 mujeres españolas, con una tasa de mortalidad estandarizada de 18,6 por 100.000 mujeres-año. Desde los años 90 la mortalidad por cáncer de mama está descendiendo debido al diagnóstico precoz por programas de cribado y a los avances terapéuticos. En España esta tendencia decreciente se observa a partir de 1993, con un descenso de un 2,4% anual.La supervivencia global en Europa a los 5 años es cercana al 79%, inferior a la observada en EEUU (90%), y ha aumentado en los últimos años. En España, se sitúa en un 83%, significativamente más alta que la media europea. Breast cancer is the most frequent neoplasm in Europe. According to the International Agency for Research on Cancer, there were an estimated 429,900 cases diagnosed in Europe in 2006, with an age-standardised incidence rate of 110 cases per 100,000 women.It is also the most frequent cancer in Spanish women, accounting for one forth of female cancer cases, and its incidence is increasing around 2-3% per year. Changes in reproductive behaviour and life style along with the introduction of hormone replacement therapy are partially responsible of this trend. Our country, with an estimated age-standardised incidence rate of 93.6 cases per 100,000 women-year in 2006, occupies an intermediate position between Western and Eastern European countries.This tumour also represents an important cause of female mortality. In 2005, it caused 5,703 deaths in Spanish women, with an age-standardised mortality rate of 18.6 per 100,000 women-year. However, since the 90’s, breast cancer mortality is declining thanks to earlier diagnosis derived from population screening programs and to therapeutical advances. In Spain this downward trend has started in 1993, declining a 2.4% per year.In Europe, 5-year global survival is close to 79%, lower than EEUU survival estimates (90%). Breast cancer survival has risen in recent years. In Spain, 5-year survival is around 83%, significantly higher than European average. Sí
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- 2007
31. Erratum: Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk (Nature Communications (2014) 5:5303 (DOI:10.1038/ncomms6303))
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Lindström, Sara, Thompson, Deborah J., Paterson, Andrew D., Jingmei, Li, Gierach, Gretchen L., Scott, Christopher, Stone, Jennifer, Douglas, Julie A., Dos Santos Silva, Isabel, Fernandez Navarro, Pablo, Verghase, Jajini, Smith, Paula, Brown, Judith, Luben, Robert, Wareham, Nicholas J., Loos, Ruth J. F., Heit, John A., Pankratz, V. Shane, Norman, Aaron, Goode, Ellen L., Cunningham, Julie M., Deandrade, Mariza, Vierkant, Robert A., Czene, Kamila, Fasching, Peter A., Baglietto, Laura, Southey, Melissa C., Giles, Graham G., Shah, Kaanan P., Chan, Heang Ping, Helvie, Mark A., Beck, Andrew H., Knoblauch, Nicholas W., Hazra, Aditi, Hunter, David J., Kraft, Peter, Pollan, Marina, Figueroa, Jonine D., Couch, Fergus J., Hopper, John L., Hall, Per, Easton, Douglas F., Boyd, Norman F., Vachon, Celine M., and Tamimi, Rulla M.
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Genetics and Molecular Biology (all) ,Physics and Astronomy (all) ,Chemistry (all) ,Biochemistry, Genetics and Molecular Biology (all) ,Biochemistry - Published
- 2015
32. Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk
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Lindström, Sara, Thompson, Deborah J, Paterson, Andrew D, Li, Jingmei, Gierach, Gretchen L, Scott, Christopher, Stone, Jennifer, Douglas, Julie A, dos-Santos-Silva, Isabel, Fernandez-Navarro, Pablo, Verghase, Jajini, Smith, Paula, Brown, Judith, Luben, Robert, Wareham, Nicholas J, Loos, Ruth JF, Heit, John A, Pankratz, V Shane, Norman, Aaron, Goode, Ellen L, Cunningham, Julie M, deAndrade, Mariza, Vierkant, Robert A, Czene, Kamila, Fasching, Peter A, Baglietto, Laura, Southey, Melissa C, Giles, Graham G, Shah, Kaanan P, Chan, Heang-Ping, Helvie, Mark A, Beck, Andrew H, Knoblauch, Nicholas W, Hazra, Aditi, Hunter, David J, Kraft, Peter, Pollan, Marina, Figueroa, Jonine D, Couch, Fergus J, Hopper, John L, Hall, Per, Easton, Douglas F, Boyd, Norman F, Vachon, Celine M, and Tamimi, Rulla M
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Mammographic density reflects the amount of stromal and epithelial tissues in relation to adipose tissue in the breast and is a strong risk factor for breast cancer. Here we report the results from meta-analysis of genome-wide association studies (GWAS) of three mammographic density phenotypes: dense area, non-dense area and percent density in up to 7,916 women in stage 1 and an additional 10,379 women in stage 2. We identify genome-wide significant (P
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- 2014
33. CONSULTAAUTOR Industrial pollution and pleural cancer mortality in Spain
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Lopez-Abente, Gonzalo, Fernandez-Navarro, Pablo, Boldo, Elena, Ramis, Rebeca, and Garcia-Perez, Javier
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Male ,Mesothelioma ,Risk ,Air Pollutants ,Pleural Neoplasms ,Asbestos ,Bayes Theorem ,Environmental Exposure ,Risk Factors ,Spain ,Air Pollution ,Occupational Exposure ,Epidemiological Monitoring ,Humans ,Female ,Poisson Distribution ,Environmental Monitoring - Abstract
Pleural cancer mortality is an acknowledged indicator of exposure to asbestos and mesothelioma mortality but in 15%-20% of cases no exposure can be recalled. In the past, asbestos was used in many industries and it is still found in many installations. Our objective was to ascertain whether there might be excess pleural cancer mortality among populations residing in the vicinity of Spanish industrial installations that are governed by the Integrated Pollution Prevention and Control (IPPC) Directive and the European Pollutant Release and Transfer Register Regulation and report their emissions to air. An ecological study was designed to examine pleural cancer mortality at a municipal level (8098 Spanish towns) over the period 1997-2006, during which 2146 deaths were registered. We conducted an exploratory "near vs. far" analysis to estimate the relative risks (RRs) of towns situated at a distance of
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- 2012
34. Correction: Corrigendum: Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk
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Lindström, Sara, primary, Thompson, Deborah J., additional, Paterson, Andrew D., additional, Li, Jingmei, additional, Gierach, Gretchen L., additional, Scott, Christopher, additional, Stone, Jennifer, additional, Douglas, Julie A., additional, dos-Santos-Silva, Isabel, additional, Fernandez-Navarro, Pablo, additional, Verghase, Jajini, additional, Smith, Paula, additional, Brown, Judith, additional, Luben, Robert, additional, Wareham, Nicholas J., additional, Loos, Ruth J. F., additional, Heit, John A., additional, Pankratz, V. Shane, additional, Norman, Aaron, additional, Goode, Ellen L., additional, Cunningham, Julie M., additional, deAndrade, Mariza, additional, Vierkant, Robert A., additional, Czene, Kamila, additional, Fasching, Peter A., additional, Baglietto, Laura, additional, Southey, Melissa C., additional, Giles, Graham G., additional, Shah, Kaanan P., additional, Chan, Heang-Ping, additional, Helvie, Mark A., additional, Beck, Andrew H., additional, Knoblauch, Nicholas W., additional, Hazra, Aditi, additional, Hunter, David J., additional, Kraft, Peter, additional, Pollan, Marina, additional, Figueroa, Jonine D., additional, Couch, Fergus J., additional, Hopper, John L., additional, Hall, Per, additional, Easton, Douglas F., additional, Boyd, Norman F., additional, Vachon, Celine M., additional, and Tamimi, Rulla M., additional
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- 2015
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35. Genome wide association study identifies a novel putative mammographic density locus at 1q12-q21
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Fernandez-Navarro, Pablo, primary, González-Neira, Anna, additional, Pita, Guillermo, additional, Díaz-Uriarte, Ramón, additional, Tais Moreno, Leticia, additional, Ederra, María, additional, Pedraz-Pingarrón, Carmen, additional, Sánchez-Contador, Carmen, additional, Vázquez-Carrete, Jose Antonio, additional, Moreo, Pilar, additional, Vidal, Carmen, additional, Salas-Trejo, Dolores, additional, Stone, Jennifer, additional, Southey, Melissa C., additional, Hopper, John L., additional, Pérez-Gómez, Beatriz, additional, Benitez, Javier, additional, and Pollan, Marina, additional
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- 2014
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36. Maintenance of attention and pathological gambling.
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Vizcaino, Ernesto Jose Verdura, primary, Fernandez-Navarro, Pablo, additional, Blanco, Carlos, additional, Ponce, Guillermo, additional, Navio, Mercedes, additional, Moratti, Stephan, additional, and Rubio, Gabriel, additional
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- 2013
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37. Association analysis between breast cancer genetic variants and mammographic density in a large population-based study (Determinants of Density in Mammographies in Spain) identifies susceptibility loci in TOX3 gene
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Fernandez-Navarro, Pablo, primary, Pita, Guillermo, additional, Santamariña, Carmen, additional, Moreno, María Pilar, additional, Vidal, Carmen, additional, Miranda-García, Josefa, additional, Ascunce, Nieves, additional, Casanova, Francisco, additional, Collado-García, Francisca, additional, Herráez, Belen, additional, González-Neira, Anna, additional, Benítez, Javier, additional, and Pollán, Marina, additional
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- 2013
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38. Risk of Cancer Mortality in Spanish Towns Lying in the Vicinity of Pollutant Industries
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Ramis, Rebeca, primary, Fernandez-Navarro, Pablo, additional, Garcia-Perez, Javier, additional, Boldo, Elena, additional, Gomez-Barroso, Diana, additional, and Lopez-Abente, Gonzalo, additional
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- 2012
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39. Worldwide impact of economic cycles on suicide trends over 3 decades: differences according to level of development. A mixed effect model study
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Blasco-Fontecilla, Hilario, primary, Perez-Rodriguez, M Mercedes, additional, Garcia-Nieto, Rebeca, additional, Fernandez-Navarro, Pablo, additional, Galfalvy, Hanga, additional, de Leon, Jose, additional, and Baca-Garcia, Enrique, additional
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- 2012
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40. Nucleotide variation in central nervous system genes among male suicide attempters
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Baca-Garcia, Enrique, primary, Vaquero-Lorenzo, Concepción, additional, Perez-Rodriguez, M. Mercedes, additional, Gratacòs, Mònica, additional, Bayés, Mònica, additional, Santiago-Mozos, Ricardo, additional, Leiva-Murillo, Jose Miguel, additional, de Prado-Cumplido, Mario, additional, Artes-Rodriguez, Antonio, additional, Ceverino, Antonio, additional, Diaz-Sastre, Carmen, additional, Fernandez-Navarro, Pablo, additional, Costas, Javier, additional, Fernandez-Piqueras, José, additional, Diaz-Hernandez, Montserrat, additional, de Leon, Jose, additional, Baca-Baldomero, Enrique, additional, Saiz-Ruiz, Jeronimo, additional, Mann, J. John, additional, Parsey, Ramin V., additional, Carracedo, Angel, additional, Estivill, Xavier, additional, and Oquendo, Maria A., additional
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- 2009
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41. Association study of two polymorphisms of the serotonin‐2A receptor gene and suicide attempts
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Vaquero‐Lorenzo, Concepcion, primary, Baca‐Garcia, Enrique, additional, Diaz‐Hernandez, Montserrat, additional, Perez‐Rodriguez, M. Mercedes, additional, Fernandez‐Navarro, Pablo, additional, Giner, Lucas, additional, Carballo, Juan J., additional, Saiz‐Ruiz, Jeronimo, additional, Fernandez‐Piqueras, Jose, additional, Baldomero, Enrique Baca, additional, de Leon, Jose, additional, and Oquendo, Maria A., additional
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- 2007
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42. Large-scale genotyping identifies a new locus at 22q13.2 associated with female breast size.
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Jingmei Li, Jia Nee Foo, Schoof, Nils, Varghese, Jajini S, Fernandez-Navarro, Pablo, Gierach, Gretchen L, Swee Tian Quek, Hartman, Mikael, Silje Nord, Kristensen, Vessela N, Pollán, Marina, Figueroa, Jonine D, Thompson, Deborah J, Yi Li, Chiea Chuen Khor, Humphreys, Keith, Jianjun Liu, Czene, Kamila, and Hall, Per
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SIZE of breast ,MATE selection ,META-analysis ,MAMMOGRAMS ,SINGLE nucleotide polymorphisms ,ESTROGEN - Abstract
Background Individual differences in breast size are a conspicuous feature of variation in human females and have been associated with fecundity and advantage in selection of mates. To identify common variants that are associated with breast size, we conducted a large-scale genotyping association meta-analysis in 7169 women of European descent across three independent sample collections with digital or screen film mammograms. Methods The samples consisted of the Swedish KARMA, LIBRO-1 and SASBAC studies genotyped on iCOGS, a custom illumina iSelect genotyping array comprising of 211 155 single nucleotide polymorphisms (SNPs) designed for replication and fine mapping of common and rare variants with relevance to breast, ovary and prostate cancer. Breast size of each subject was ascertained by measuring total breast area (mm
2 ) on a mammogram. Results We confirm genome-wide significant associations at 8p11.23 (rs10086016, p=1.3×10−14 ) and report a new locus at 22q13 (rs5995871, p=3.2×10−8 ). The latter region contains the MKL1 gene, which has been shown to impact endogenous oestrogen receptor α transcriptional activity and is recruited on oestradiol sensitive genes. We also replicated previous genome-wide association study findings for breast size at four other loci. Conclusions A new locus at 22q13 may be associated with female breast size. [ABSTRACT FROM AUTHOR]- Published
- 2013
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43. ATA homozigosity in the IL-10 gene promoter is a risk factor for schizophrenia in Spanish females: a case control study.
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Almoguera, Berta, Riveiro-Alvarez, Rosa, Lopez-Castroman, Jorge, Dorado, Pedro, Lopez-Rodriguez, Rosario, Fernandez-Navarro, Pablo, Baca-García, Enrique, Fernandez-Piqueras, Jose, Dal-Ré, Rafael, Abad-Santos, Francisco, LLerena, Adrián, and Ayuso, Carmen
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SCHIZOPHRENIA ,NUCLEOTIDES ,GENETIC polymorphisms ,DISEASE risk factors ,INTERLEUKIN-10 - Abstract
Background: Three IL-10 gene promoter single nucleotide polymorphisms -1082G > A, -819C > T and -592C > A and the haplotypes they define in Caucasians, GCC, ACC, ATA, associated with different IL-10 production rates, have been linked to schizophrenia in some populations with conflicting results. On the basis of the evidence of the sexdependent effect of certain genes in many complex diseases, we conducted a sex-stratified case-control association study to verify the linkage of the IL-10 gene promoter SNPs and haplotypes with schizophrenia and the possible sex-specific genetic effect in a Spanish schizophrenic population. Methods: 241 DSM-IV diagnosed Spanish schizophrenic patients and 435 ethnically matched controls were genotyped for -1082G > A and -592C > A SNPs. Chi squared tests were performed to assess for genetic association of alleles, genotypes and haplotypes with the disease. Results: The -1082A allele (p = 0.027), A/A (p = 0.008) and ATA/ATA (p = 0.003) genotypes were significantly associated with schizophrenia in females while neither allelic nor genotypic frequencies reached statistical significance in the male population. Conclusions: Our results highlight the hypothesis of an imbalance towards an inflammatory syndrome as the immune abnormality of schizophrenia. Anyway, a better understanding of the involvement of the immune system would imply the search of immune abnormalities in endophenotypes in whose sex and ethnicity might be differential factors. It also reinforces the need of performing complex gene studies based on multiple cytokine SNPs, including anti and pro-inflammatory, to clarify the immune system abnormalities direction in the etiology of schizophrenia. [ABSTRACT FROM AUTHOR]
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- 2011
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44. Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk
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Lindström, Sara, Thompson, Deborah J., Paterson, Andrew D., Li, Jingmei, Gierach, Gretchen L., Scott, Christopher, Stone, Jennifer, Douglas, Julie A., dos-Santos-Silva, Isabel, Fernandez-Navarro, Pablo, Verghase, Jajini, Smith, Paula, Brown, Judith, Luben, Robert, Wareham, Nicholas J., Loos, Ruth J.F., Heit, John A., Pankratz, V. Shane, Norman, Aaron, Goode, Ellen L., Cunningham, Julie M., deAndrade, Mariza, Vierkant, Robert A., Czene, Kamila, Fasching, Peter A., Baglietto, Laura, Southey, Melissa C., Giles, Graham G., Shah, Kaanan P., Chan, Heang-Ping, Helvie, Mark A., Beck, Andrew H., Knoblauch, Nicholas W., Hazra, Aditi, Hunter, David J., Kraft, Peter, Pollan, Marina, Figueroa, Jonine D., Couch, Fergus J., Hopper, John L., Hall, Per, Easton, Douglas F., Boyd, Norman F., Vachon, Celine M., and Tamimi, Rulla M.
- Abstract
Mammographic density reflects the amount of stromal and epithelial tissues in relation to adipose tissue in the breast and is a strong risk factor for breast cancer. Here we report the results from meta-analysis of genome-wide association studies (GWAS) of three mammographic density phenotypes: dense area, non-dense area and percent density in up to 7,916 women in stage 1 and an additional 10,379 women in stage 2. We identify genome-wide significant (P<5×10−8) loci for dense area (AREG, ESR1, ZNF365, LSP1/TNNT3, IGF1, TMEM184B, SGSM3/MKL1), non-dense area (8p11.23) and percent density (PRDM6, 8p11.23, TMEM184B). Four of these regions are known breast cancer susceptibility loci, and four additional regions were found to be associated with breast cancer (P<0.05) in a large meta-analysis. These results provide further evidence of a shared genetic basis between mammographic density and breast cancer and illustrate the power of studying intermediate quantitative phenotypes to identify putative disease susceptibility loci.
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- 2015
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45. Corrigendum: Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk.
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Lindström, Sara, Thompson, Deborah J., Paterson, Andrew D., Li, Jingmei, Gierach, Gretchen L., Scott, Christopher, Stone, Jennifer, Douglas, Julie A., dos-Santos-Silva, Isabel, Fernandez-Navarro, Pablo, Verghase, Jajini, Smith, Paula, Brown, Judith, Luben, Robert, Wareham, Nicholas J., Loos, Ruth J. F., Heit, John A., Pankratz, V. Shane, Norman, Aaron, and Goode, Ellen L.
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- 2015
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46. Municipal distribution of the incidence of the most common tumours in an area with high cancer mortality
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Viñas Casasola, Manuel Jesús, Fernández Navarro, Pablo, Fajardo Rivas, María Luisa, Gurucelain Raposo, José Luis, Alguacil Ojeda, Juan, [Vinas Casasola, Manuel Jesus] Consejeria Salud Junta Andalucia, Delegac Terr Huelva, Huelva, Spain, [Fajardo Rivas, Maria Luisa] Consejeria Salud Junta Andalucia, Delegac Terr Huelva, Huelva, Spain, [Gurucelain Raposo, Jose Luis] Consejeria Salud Junta Andalucia, Delegac Terr Huelva, Huelva, Spain, [Fernandez Navarro, Pablo] Inst Salud Carlos III, Ctr Nacl Epidemiol, Area Epidemiol Ambiental & Canc, Madrid, Spain, [Fernandez Navarro, Pablo] GIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain, [Alguacil Ojeda, Juan] GIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain, and [Alguacil Ojeda, Juan] Univ Huelva, Ctr Invest Salud & Med Ambiente CYSMA, Huelva, Spain
- Subjects
Public health ,Epidemiology ,Spain ,Maps ,Bladder-cancer ,Epidemiología ,Cáncer ,Salud Pública ,Mapas ,Huelva ,Patterns ,Cancer - Abstract
Resumen Objetivo: Describir los patrones de distribución geográfica de la incidencia municipal de los tumores más frecuentes en la provincia de Huelva y compararla con la estimada para el conjunto de España. Método: Se calcularon los riesgos relativos (RR) usando el modelo condicional autorregresivo propuesto por Besag, York y Mollié mediante la herramienta INLA, para los años 2007-2011, de las siguientes localizaciones: colon, recto y ano en hombres y en mujeres; tráquea, bronquios y pulmón, próstata y vejiga en hombres; y mama en mujeres. Estos RR se representaron en mapas de coropletas y de isopletas (mediante interpolación por kriging). Resultados: Los RR para cáncer de vejiga en hombres fueron superiores a 1 en todos los municipios, siendo sus intervalos de credibilidad superiores a la unidad en cuatro municipios, destacando la capital con 1,56 (intervalo de credibilidad al 95%:1,30-1,67). Para el cáncer de próstata, las probabilidades a posteriori en 68 de los 79 municipios quedaron por debajo de 0,1. Para el cáncer de pulmón, nueve municipios mostraron intervalos de credibilidad por debajo de la unidad, casi todos en la zona oriental. En las mujeres, los RR para cáncer de mama fueron significativamente superiores en la zona de la capital. Finalmente, las tasas de incidencia provincial de Huelva muestran en general valores próximos a las estimadas para el conjunto de España, destacando las diferencias en cáncer de vejiga en hombres (35% superior) y en cáncer de próstata (30% inferior). Conclusiones: En la provincia de Huelva existe una distribución espacial municipal de la incidencia de cáncer con unos patrones bien definidos para algunas localizaciones tumorales concretas, presentando en general unas tasas de incidencia cercanas a las del territorio nacional. Abstract Objective: To describe the geographic distribution patterns of the municipal incidence of the most common tumours in the Huelva province (Spain) as compared to the estimated incidence for all of Spain. Methods: Relative risk (RR) was computed based on the conditional autoregressive model proposed by Besag, York and Mollié by applying the INLA tool to the cancer data for 2007-2011 for the following tumour locations: colon, rectum and anus (men and women); trachea, bronchia, and lungs, prostate and bladder in men; and breasts in women. The RR was presented in in choropleth and isopleth (with kriging interpolation) risk maps. Results: RR for bladder cancer in men was greater than 1.0 in all municipalities, with confidence intervals over 1.0 in four municipalities; Madrid having a 1.56 RR (95%CI 1.30-1.67). For prostate cancer, a posteriori probabilities were below 0.1 in 68 of the 79 municipalities. For lung cancer, nine municipalities had confidence limits below 1.0, almost all of them in western Spain. For women, the RR for breast cancer was significantly higher in the capital of province area. The cancer incidence rates for the Huelva province were, in general, similar to those estimated for Spain, standing out bladder cancer in men (35% higher) and prostate cancer (30% lower). Conclusions: In the Huelva province, there is a geographical municipal distribution of cancer incidence with well-defined patterns for some specific tumour locations, with overall incidence rates very similar to those in the rest of Spain.
- Published
- 2017
47. Nucleotide variation in central nervous system genes among male suicide attempters.
- Author
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Baca-Garcia E, Vaquero-Lorenzo C, Perez-Rodriguez MM, Gratacòs M, Bayés M, Santiago-Mozos R, Leiva-Murillo JM, de Prado-Cumplido M, Artes-Rodriguez A, Ceverino A, Diaz-Sastre C, Fernandez-Navarro P, Costas J, Fernandez-Piqueras J, Diaz-Hernandez M, de Leon J, Baca-Baldomero E, Saiz-Ruiz J, Mann JJ, Parsey RV, Carracedo A, Estivill X, and Oquendo MA
- Subjects
- Adult, Humans, Male, Polymorphism, Single Nucleotide, Sensitivity and Specificity, Central Nervous System metabolism, Suicide, Attempted
- Abstract
Despite marked morbidity and mortality associated with suicidal behavior, accurate identification of individuals at risk remains elusive. The goal of this study is to identify a model based on single nucleotide polymorphisms (SNPs) that discriminates between suicide attempters and non-attempters using data mining strategies. We examined functional SNPs (n = 840) of 312 brain function and development genes using data mining techniques. Two hundred seventy-seven male psychiatric patients aged 18 years or older were recruited at a University hospital psychiatric emergency room or psychiatric short stay unit. The main outcome measure was history of suicide attempts. Three SNPs of three genes (rs10944288, HTR1E; hCV8953491, GABRP; and rs707216, ACTN2) correctly classified 67% of male suicide attempters and non-attempters (0.50 sensitivity, 0.82 specificity, positive likelihood ratio = 2.80, negative likelihood ratio = 1.64). The OR for the combined three SNPs was 4.60 (95% CI: 1.31-16.10). The model's accuracy suggests that in the future similar methodologies may generate simple genetic tests with diagnostic utility in identification of suicide attempters. This strategy may uncover new pathophysiological pathways regarding the neurobiology of suicidal acts., ((c) 2009 Wiley-Liss, Inc.)
- Published
- 2010
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