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Cardiovascular diseases (CVD) are the leading cause of death globally (1). The risk increases with age. Statins and ezetimibe are indicated for the prevention of CVD and its efficacy in secondary prevention (patients who have had an adverse CVD event) has been demonstrated in all age groups (2). However, there is controversy about its use in primary prevention (people without established CVD) in the elderly (3, 4), since the patients older than 75 years are a group of underrepresented population in clinical trials. This age threshold has been used in meta-analysis of randomized controlled trials that did not shown evidence of an effect in cardiovascular events in people older than 75 years without vascular disease (5–7) . The latest clinical guidelines published in the United States and Europe differ notably in their recommendations (8–10). As other medicines, statins and ezetimibe are not exempt from adverse events. These are more frequent in geriatric patients, since comorbidities and polypharmacy frequently coexist. These factors can increase the risk of drug interactions and contribute to the impairment of renal and hepatic function (11). We describe a protocol for a systematic review that will evaluate the effectiveness and safety of statins and ezetimibe in people over 75 years of age.

This paper presents a hybrid metal-graphene printed Yagi antenna with reconfigurable gain that operates in the 5.5-GHz band. The balun and the driven elements are made of copper, while the directors are made of graphene. The graphene acts as a tunable material in the design. By switching the conductivity of the graphene, it is achieved a similar effect to adding or subtracting directors in the antenna. Hence the gain of the printed Yagi can be easily controlled. This could be of special interest in RF energy harvesting in the design of reconfigurable harvesting elements. Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.

This work presents a new configuration to create glide-symmetric structures in a single plane, which can be printed on the metallic face of a dielectric substrate. This type of glide symmetry facilitates the fabrication and avoids alignment problems in the assembly process when compared to traditional glide-symmetric structures based on several planes. This article also includes a study based on dispersion diagrams on the appearance of stop-bands by breaking the symmetry. Finally, we present the simulated S parameters of structures with 10×10 unit cells to illustrate the attenuation in these stop-bands.