82 results on '"Fernandez-Alvarez, J"'
Search Results
2. Experiencia en pacientes geriátricos del servicio de Gastrocirugía en el Hospital Español de México 2013-2019. Gastrocirugía en pacientes geriátricos: experiencia de 5 años
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Fernández-Álvarez, J., Cores-Ogando, V., Rodríguez-Bustos, B., and Turrent-Pinedo, R.
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- 2023
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3. Dropping out of a transdiagnostic online intervention: A qualitative analysis of client's experiences
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Fernández-Álvarez, J., Díaz-García, A., González-Robles, A., Baños, R., García-Palacios, A., and Botella, C.
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- 2017
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4. A Posteriori Inference of Model Parameters in a Geophysical Inverse Problem Using GA
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Fernández-Álvarez, J. Paulino, Fernández-Martínez, Juan Luis, Menéndez-Pérez, C. Omar, Kacprzyk, Janusz, editor, López-Díaz, Miguel, Gil, María Á., Grzegorzewski, Przemysław, Hryniewicz, Olgierd, and Lawry, Jonathan
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- 2004
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5. IAPP and Insulin Regulation in Human Pancreatic Islets
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Novials, A., Gasa, R., Fernandez-Alvarez, J., Gomis, R., and Soria, Bernat, editor
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- 1997
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6. Optiflow vs Vapotherm as extended weaning mode from nasal continuous positive airway pressure in preterm infants ≤ 28 weeks gestational age
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Fernandez‐Alvarez, J. Ramon, primary, Mahoney, Liam, additional, Gandhi, Rashmi, additional, and Rabe, Heike, additional
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- 2020
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7. Diagnostic tests for congenital cytomegalovirus infection
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Gandhi, R S, Fernandez-Alvarez, J-R, and Rabe, H
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- 2010
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8. Diagnostic value of subependymal pseudocysts and choroid plexus cysts on neonatal cerebral ultrasound: a meta-analysis
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Fernandez Alvarez, J R, Amess, P N, Gandhi, R S, and Rabe, H
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- 2009
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9. Enzymatic, metabolic and secretory patterns in human islets of Type 2 (non-insulin-dependent) diabetic patients
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Fernandez-Alvarez, J., Conget, I., Rasschaert, J., Sener, A., Gomis, R., and Malaisse, W. J.
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- 1994
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10. Semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 activity exerts an antidiabetic action in Goto-Kakizaki rats. (Islet Studies)
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Abella, Anna, Marti, Luc, Camps, Marta, Claret, Marc, Fernandez-Alvarez, J., Gomis, Ramon, Guma, Anna, Viguerie, Nathalie, Carpene, Christian, Palacin, Manuel, Testar, Xavier, and Zorzano, Antonio
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Diabetes therapy -- Research -- Physiological aspects -- Models ,Glucose metabolism -- Physiological aspects -- Models -- Research ,Type 2 diabetes -- Physiological aspects -- Models -- Research ,Health ,Physiological aspects ,Models ,Research - Abstract
In this study we have explored whether the bifunctional protein semicarbazide-sensitive amine oxidase (SSAO)/ vascular adhesion protein-1 (VAP-1) represents a novel target for type 2 diabetes. To this end, Goto-Kakizaki (GK) diabetic rats were treated with the SSAO substrate benzylamine and with low ineffective doses of vanadate previously shown to have antidiabetic effects in streptozotocin-induced diabetic rats. The administration of benzylamine in combination with vanadate in type 2 diabetic rats acutely stimulated glucose tolerance, and the chronic treatment normalized hyperglycemia, stimulated glucose transport in adipocytes, and reversed muscle insulin resistance. Acute in vivo administration of benzylamine and vanadate stimulated skeletal muscle glucose transport, an effect that was also observed in incubated muscle preparations coincubated with adipose tissue explants or with human recombinant SSAO. Acute administration of benzylamine/vanadate also ameliorated insulin secretion in diabetic GK rats, and this effect was also observed in incubated pancreatic islets. In keeping with these observations, we also demonstrate that pancreatic islets express SSAO/ VAP-1. As far as mechanisms of action, we have found that benzylamine/vanadate causes enhanced tyrosine phosphorylation of proteins and reduced protein tyrosine phosphatase activity in adipocytes. In addition, incubation of human recombinant SSAO, benzylamine, and vanadate generates peroxovanadinm compounds in vitro. Based on these data, we propose that benzylamine/vanadate administration generates peroxovanadium locally in pancreatic islets, which stimulates insulin secretion and also produces peroxovanadium in adipose tissue, activating glucose metabolism in adipocytes and in neighboring muscle. This opens the possibility of using the SSAO/VAP-1 activity as a local generator of protein tyrosine phosphatase inhibitors in antidiabetic therapy. Diabetes 52:1004-1013, 2003, The semicarbazide-sensitive amine oxidase (SSAO)/vascular adhesion protein-1 (VAP-1) is a bifunctional membrane protein. On one hand, SSAO/VAP-1 is a copper-containing ectoenzyme with amine oxidase activity that is inhibited by carbonylreactive [...]
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- 2003
11. Towards Fully Coupled Finite Element Modelling of DC resistivity in Complex Seawater Intrusion Scenarios
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Gonzalez Quiros, A., primary, Comte, J., additional, Rubio-Melendi, D., additional, and Fernandez-Alvarez, J., additional
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- 2019
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12. A Computational and Experimental Investigation of λ/2 and λ/4 Sampling Step in Phaseless Planar Near-Field Measurements at 60GHz
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Fernandez Alvarez, J., primary and Breinbjerg, O., additional
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- 2018
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13. Discovery of a mass grave from the Spanish Civil War using GPR and forensic archaeology
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Fernandez-Alvarez, J-P, Rubio-Melendi, D, Martinez-Velasco, A, Pringle, JK, and Aguilera, D
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RA1001 - Abstract
An estimated 500,000 people died from all causes during the Spanish Civil War between 1936 and 1939, with a further 135,000 killed after the war ended. There are currently over 2,000 known mass burial locations throughout Spain but many more are unknown. This study details the successful search for an unmarked mass grave in mountainous terrain in the Asturias region of Northern Spain. Two approximate locations were known due to eyewitness accounts. A phased site investigation approach was undertaken, which included ground penetrating radar. Results showed a clear geophysical anomaly on 2D GPR profiles. The identified area was subsequently intrusively investigated by forensic archaeologists and human remains were successfully discovered. Careful and sensitive investigations are essential in these approaches where living relatives are involved.
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- 2016
14. Metabolic and functional studies on islets isolated from a new rat model of type 2 diabetes
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Novelli, Michela, Fernandez Alvarez, J, Fabregat, Me, Gomis, R, and Masiello, Pellegrino
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- 1999
15. Diagnosis of grey matter heterotopia on cerebral ultrasound in a newborn: lessons from a case report for daily clinical practice
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Fernandez Alvarez, J R, primary, Moorthy, Ima, additional, Kenney, Ian Joseph, additional, and Rabe, Heike, additional
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- 2012
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16. 1055 All-In-One Versus Two-Compartment Parenteral Nutrition in Extremely Preterm Infants < 27 Weeks Gestation and < 1000 G Birthweight (ELBWI)
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Doyle, S S R, primary, Fernandez-Alvarez, J R, additional, Pettit, M, additional, and Rabe, H, additional
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- 2010
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17. Negative and Positive Affect Regulation in a Transdiagnostic Internet-Based Protocol for Emotional Disorders: Randomized Controlled Trial
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Díaz-García, Amanda, González-Robles, Alberto, García-Palacios, Azucena, Fernández-Álvarez, Javier, Castilla, Diana, Bretón, Juana María, Baños, Rosa María, Quero, Soledad, and Botella, Cristina
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Computer applications to medicine. Medical informatics ,R858-859.7 ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundEmotional disorders (EDs) are among the most prevalent mental disorders. Existing evidence-based psychological treatments are not sufficient to reduce the disease burden of mental disorders. It is therefore essential to implement innovative solutions to achieve a successful dissemination of psychological treatment protocols, and in this regard, the use of information and communication technologies such as the internet can be very useful. Furthermore, the literature suggests that not everyone with an ED receives the appropriate treatment. This situation has led to the development of new intervention proposals based on the transdiagnostic perspective, which attempts to address the underlying processes common to EDs. Most of these transdiagnostic interventions focus primarily on downregulating negative affectivity (NA), and less attention has been paid to strengths and the upregulation of positive affectivity, despite its importance for well-being and mental health. ObjectiveThis study aims to evaluate the efficacy of a transdiagnostic internet-based treatment for EDs in a community sample. MethodsA 3-armed randomized controlled trial was conducted. A total of 216 participants were randomly assigned to a transdiagnostic internet-based protocol (TIBP), a TIBP+ positive affect (PA) component, or a waiting list (WL) control group. The treatment protocol contained core components mainly addressed to downregulate NA (ie, present-focused emotional awareness and acceptance, cognitive flexibility, behavioral and emotional avoidance patterns, and interoceptive and situational exposure) as well as a PA regulation component to promote psychological strengths and enhance well-being. Data on depression, anxiety, quality of life, neuroticism and extraversion, and PA/NA before and after treatment were analyzed. Expectations and opinions of treatment were also analyzed. ResultsWithin-group comparisons indicated significant pre-post reductions in the two experimental conditions. In the TIBP+PA condition, the effect sizes were large for all primary outcomes (d=1.42, Beck Depression Inventory [BDI-II]; d=0.91, Beck Anxiety Inventory [BAI]; d=1.27, Positive and Negative Affect Schedule-Positive [PANAS-P]; d=1.26, Positive and Negative Affect Schedule-Negative [PANAS-N]), whereas the TIBP condition yielded large effect sizes for BDI-II (d=1.19) and PANAS-N (d=1.28) and medium effect sizes for BAI (d=0.63) and PANAS-P (d=0.69). Between-group comparisons revealed that participants who received one of the two active treatments scored better at posttreatment than WL participants. Although there were no statistically significant differences between the two intervention groups on the PA measure, effect sizes were consistently larger in the TIBP+PA condition than in the standard transdiagnostic protocol. ConclusionsOverall, the findings indicate that EDs can be effectively treated with a transdiagnostic intervention via the internet, as significant improvements in depression, anxiety, and quality of life measures were observed. Regarding PA measures, promising effects were found, but more research is needed to study the role of PA as a therapeutic component. Trial RegistrationClinicalTrials.gov NCT02578758; https://clinicaltrials.gov/ct2/show/NCT02578758 International Registered Report Identifier (IRRID)RR2-10.1186/s12888-017-1297-z
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- 2021
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18. Culture of Differentiated Adult Rabbit Auricular Chondrocytes
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Villar, V., primary, Colaco, B., additional, Calles-Venal, I., additional, Fernandez-Alvarez, J. G., additional, Fernandez-Caso, M., additional, and Villar, J. M., additional
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- 2005
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19. 114 Comparison of Capillary Reactivity by White Light Spectroscopy with Laboratory Markers in Nosocomial Neonatal Sepsis
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Fernandez Alvarez, J R, primary, Lawson, F E, additional, Watkins, R, additional, Lawn, C, additional, Jungmann, H, additional, and Rabe, H, additional
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- 2005
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20. 115 Blood Sugar Monitoring in Preterm Infants < 31 Weeks and < 1000 G
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Fernandez Alvarez, J R, primary, Graham-Evans, K, additional, Smyth, J P, additional, Amess, P N, additional, and Rabe, H, additional
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- 2005
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21. Hirschsprung's disease as a rare cause of refractory constipation in an adult patient
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Alcocer-Sánchez, E., Pérez y López, N., Fernández-Álvarez, J., and Zárate-Osorno, A.
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- 2019
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22. Enfermedad de Hirschsprung como causa rara de estreñimiento refractario en un paciente adulto
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Alcocer-Sánchez, E., Pérez y López, N., Fernández-Álvarez, J., and Zárate-Osorno, A.
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- 2019
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23. Metabolic and functional studies on isolated islets in a new rat model of type 2 diabetes
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Novelli, M., primary, Fabregat, M.E., additional, Fernandez-Alvarez, J., additional, Gomis, R., additional, and Masiello, P., additional
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- 2001
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24. 4-Hydroxyisoleucine: a novel amino acid potentiator of insulin secretion
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Sauvaire, Y., primary, Petit, P., additional, Broca, C., additional, Manteghetti, M., additional, Baissac, Y., additional, Fernandez-Alvarez, J., additional, Gross, R., additional, Roye, M., additional, Leconte, A., additional, Gomis, R., additional, and Ribes, G., additional
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- 1998
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25. Immunodetection of Mitochondrial Glycerophosphate Dehydrogenase (mGDH) by a Polyclonal Antibody Raised against a Recombinant mGDH Fragment Product
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Novials, A., primary, Fabregat, M.E., additional, Benito, C., additional, Fernandez-Alvarez, J., additional, Gallart, T., additional, Malaisse, W.J., additional, and Gomis, R., additional
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- 1996
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26. Signals derived from glucose metabolism are required for glucose regulation of pancreatic islet GLUT2 mRNA and protein
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Ferrer, J., primary, Gomis, R., additional, Fernandez Alvarez, J., additional, Casamitjana, R., additional, and Vilardell, E., additional
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- 1993
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27. Management of congenital cytomegalovirus infection: an evidence-based approach.
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Gandhi, R. S., Fernandez-Alvarez, J. R., and Rabe, H.
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CYTOMEGALOVIRUS diseases , *HERPESVIRUS diseases , *PSYCHOMOTOR disorders , *MOVEMENT disorders , *NEUROLOGICAL disorders - Abstract
Despite cytomegalovirus being the most common congenital infection leading to psychomotor impairment and sensori-neural hearing loss, little is known about early identification and management of congenitally infected neonates. This article reviews the literature and devises an algorithm for identification and management of these neonates. Conclusion: Application of the current knowledge in the management of congenital cytomegalovirus infected neonates could be beneficial, until further evidence is available. [ABSTRACT FROM AUTHOR]
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- 2010
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28. Adsorptive voltammetric behaviour of immunoglobulin M
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Fernandez Alvarez, J, primary
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- 1991
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29. Pitfalls bei der Diagnose des kongenitalen Hyperinsulinismus: Ein Fallbericht und �bersicht der Literatur.
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Fernandez Alvarez, J. R., Rabe, H., Wilichowski, E., and Pekrun, A.
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- 2006
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30. Observaciones en el punto de unión neuroectodermo-ectodermo no neural en embriones de pollo en neurulación tratados con citocalasina B ≪in ovo≫.
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Fernandez-Caso, M., Fernandez-Alvarez, J. G., Chamorro, C. A., Paz, P. de, and Villar, J. M.
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- 1987
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31. Estimation of pharmacokinetic parameters of sodium tungstate after multiple-dose during preclinical studies in beagle dogs
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Lamer, S. Le, Cros, G., Serrano, J. J., Pinol, C., Fernandez-Alvarez, J., and Bressolle, F.
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- 2001
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32. 35th Annual Meeting of the European Association for the Study of Diabetes
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Melander, A., Olsson, J., Lindberg, G., Salzman, A., Howard, T., Stang, P., Lydick, E., Emslie-Smith, A., Boyle, D. I. R., Evans, J. M. M., Macdonald, T. M., Bain, J., Sullivan, F., Juhl, C., Pørksen, N., Sturis, J., Hollingdal, M., Pincus, S., Veldhuis, J., Dejgaard, A., Schmitz, O., Kristensen, J. S., Frandsen, K. B., Bayer, Th., Müller, P., Dunning, B. E., Paladini, S., Gutierrez, C., Deacon, R., Valentin, M., Grunberger, G., Weston, W. M., Patwardhan, R., Rappaport, E. B., Sargeant, L. A., Wareham, N. J., Khaw, K. T., Zethelius, Björn, Lithell, Hans, Hales, C. Nicholas, Berne, Christian, Lakka, H.-M., Oksanen, L., Tuomainen, T.-P., Kontula, K., Salonen, J. T., Dekker, J. M., de Boks, P., de Vegt, F., Stehouwer, C. D. A., Nijpels, G., Bouter, L. M., Heine, R. J., Bruno, G., Cavallo-Perin, P., Bargero, G., D’Errico, N., Borra, M., Macchia, G., Pagano, G., Newton, R. W., Ruta, D. A., New, J. P., Wallace, C., Roxburgh, M. A., Young, R. J., Vaughan, N. J. A., Elliott, P., Brennan, G., Devers, M., MacAlpine, R., Steinke, D., Lawson, D. H., Decallonne, B., Casteels, K., Gysemans, C., Bouillon, R., Mathieu, C., Linn, Thomas, Strate, Christine, Schneider, Kerstin, Funda, D. P., Jirsa, M., Kozáková, H., Kaas, A., Kofronová, O., Tlaskalová-Hogenová, H., Buschard, K., Wanka, H., Hartmann, A., Kuttler, B., Rasmussen, S. B., Sørensen, T. S., Markholst, H., Petersen, J. S., Karounos, D., Dyrberg, T., Mabley, J. G., Haskó, G., Szabó, C., Seissler, J., Nguyen, T. B. T., Steinbrenner, H., Scherbaum, W. A., Cipriani, R., Gabriele, A., Sensi, M., Guidobaldi, L., Pantellini, F., Cerrito, M. G., Scarpa, S., Di Mario, U., Morano, S., Ceolotto, G., Iori, E., Baritono, E., Del Prato, S., Semplicini, A., Trevisan, R., Zerbini, G., Meregalli, G., Asnaghi, V., Tentori, F., Maestroni, A., Mangili, R., Marescotti, C., Vedovato, M., Tiengo, A., Tadjieva, J., Mankovsky, B. N., Van Aken, S., Raes, A., Vande Walle, J., Matthys, D., Craen, M., Hansen, H. P., Lund, S. S., Rossing, P., Jensen, T., Parving, H.-H., Andersen, S., Tarnow, L., Hansen, B. V., Trautner, C., Haastert, B., Ennenbach, N., Willich, S., Tabák, Á. Gy., Orchard, T. J., Spranger, J., Preissner, K. T., Schatz, H., Pfeiffer, A., Cantón, A., Burgos, R., Hernández, C., Lecube, A., Mesa, J., Segura, R. M., Mateo, C., Simó, R., Fathallah, L., Greene, D. A., Obrosova, I., Gilbert, R. E., Kelly, D. J., Cox, A. J., Berka-Wilkinson, J. L., Taylor, H. R., Panagiotopoulos, S., Lee, V., Jerums, G., Cooper, M. E., Hitman, G. A., Aganna, E., Ogunkolade, W. B., Rema, M., Deepa, R., Shanthi-Rani, C. S., Barakat, K., Kumarajeewa, T. R., Cassell, P. G., McDermott, M. F., Mohan, V., Ways, K., Bursell, S., Devries, T., Woodworth, J., Alatorre, C., King, G., Aiello, L. P., Karisen, A. E., Pavlovic, D., Nielsen, K., Jensen, J., Andersen, H. U., Pociot, F., Mandrup-Poulsen, T., Eizirik, D. L., Nerup, J., Lortz, S., Tiedge, M., Lenzen, S., Lally, F. J., Bone, A. J., Darville, M. I., Ho, Y.-S., Sternesjö, J., Sandler, S., Chen, M.-C., Schuit, F., Pipeleers, D. G., Merezak, S., Hardikar, A., Hoet, J. J., Remacle, C., Reusens, B., Bréant, B., Garofano, A., Czernichow, P., Kubota, N., Terauchi, Y., Miki, H., Tamemoto, H., Yamauchi, T., Nakano, R., Komeda, K., Eto, K., Tobe, K., Kimura, S., Kadowaki, T., Ide, T., Murakami, K., Tsunoda, M., Mochizuki, T., Ozanne, S. E., Nave, B. T., Wang, C. L., Dorling, M. W., Petry, C. J., Koopmans, S. J., van der Bent, C., Que, I., Radder, J. K., Sebokova, E., Sana, A. K., Klimes, I., Ruderman, N., Morviducci, L., Pastore, L., Morelli, S., Sagratella, E., Zorretta, D., Buongiomo, A., Tamburrano, G., Giaccari, A., Martinenghi, Sabina, De Angelis, Gabriella Cusella, Ravasi, Flavio, Bifari, Francesco, Bordignon, Claudio, Falqui, Luca, Kessler, A., Dransfeld, O., Sasson, S., Tomas, E., Zorzano, A., Eckel, J., Thorsby, P., Rosenfalck, A. M., Kjems, L., Hanssen, K. F., Madsbad, S., Birkeland, K. I., Hamilton-Wessler, M., Markussen, J., Bergman, R. N., Melki, V., Hanaire-Broutin, H., Bessières-Lacombe, S., Tauber, J.-P., Home, P. D., Lindholm, A., Riis, A., Rosenstock, J., Schwartz, S., Clark, C., Edwards, M., Donley, D., Swift, P., Mortensen, H. B., Lynggaard, H., Hougaard, P., Cull, C. A., Neil, H. A. W., Frighi, V., Manley, S. E., Holman, R. R., Turner, R. C., Steiner, G., Davis, W. A., Weeraratna, T., Bruce, D. G., Davis, T. M. E., Vergès, B., Duvillard, L., Pont, F., Florentin, E., Gambert, Ph., Benko, B., Ljubić, S., Turk, Z., Granić, M., März, W., Wollschläger, H., Klein, G., Neiss, A., Wehling, M., Huxtable, S. J., Saker, P. J., Walker, M., Frayling, T. M., Levy, J. C., O’Rahilly, S., Hattersley, A. T., McCarthy, M. I., Orecchio, A., Giacchini, A., Dominici, R., Canettieri, G., Trinti, B., Zani, M., Andreoli, M., Sciacchitano, S., de Silva, A. M., Whitecross, K., Pasco, J., Kotowicz, M., Nicholson, G., Zimmet, P., Boyko, E. J., Collier, G. R., Frittitta, L., Pizzuti, A., Argiolas, A., Graci, S., Goldfine, I. D., Bozzali, M., Ercolino, T., Costanzo, B., Iacoviello, L., Tassi, V., Trischitta, V., Wauters, M., Rankinen, T., Mertens, I., Chagnon, M., Bouchard, C., Van Gaal, L., Sivenius, K., Valve, R., Hakkarainen, V., Niskanen, L., Laakso, M., Uusitupa, M., Beridze, N., Japaridze, M., Kurashvili, R., Dundua, M., Kebuladze, G., Kazakhashvili, N., Offley-Shore, B., Thomas, B., Ghebremeskel, K., Crawford, M., Lowy, C., Eriksson, Ulf J., Martin Simán, C., Wisse, Bert, Gittenberger-de Groot, Adriana C., Wentzel, P., Eriksson, U. J., Wender-Ożegowska, E., Drews, K., Biczysko, R., Bronisz, A., Rość, D., Graczykowska-Koczorowska, A., Kotschy, M., Sokup, A., Kohnert, K. D., Besch, W., Strese, J., Frick, U., Zander, E., Kemer, W., Škrha, J., Kvasnička, J., Kalvodová, B., Hilgertová, J., Schatteman, K., Goossens, F., Scharpé, S., De Leeuw, I., Hendriks, D., Legakis, I. N., Panayiotou, D., Mountokalakis, Th. D., Enderle, M. D., Beckmann, P., Balletshofer, B., Rittig, K., Maerker, E., Volk, A., Meisner, C., Jacob, S., Matthaei, S., Häring, H. U., Rett, K., Ueda, K., Nakagawa, T., Shimajiri, Y., Kokawa, M., Matsumoto, E., Sasaki, H., Sanke, T., Nanjo, K., McKinnon, Caroline M., Macfarlane, Wendy M., Docherty, Kevin, Furukawa, N., Shirotani, T., Kishikawa, H., Kaneko, K., Araki, E., Shichiri, M., Prentki, M., Roduit, R., Susini, S., Buteau, J., Ejrnæs, A. M., Andersen, N. Aa., Osterhoff, M., Möhlig, M., Ortmann, J., Bikashaghi, F., Mayer, C., Bikashagi, F., Ackermans, M. T., Pereira Arias, A. M., Bisschop, P. H. L. T., Endert, E., Sauerwein, H. P., Romijn, J. A., Gastaldelli, A., Baldi, S., Pettiti, M., Natali, A., Frascerra, S., Camastra, S., Toschi, E., Ferrannini, E., Stingl, H., Krssak, M., Bischof, M. G., Krebs, M., Fürnsinn, C., Nowotny, P., Waldhäusl, W., Roden, M., Neeft, M., Meijer, A. J., Båvenholm, P., Pigon, J., Efendic, S., Kästenbauer, T., Sauseng, S., Sokol, G., Auinger, M., Irsigler, K., Abbott, C. A., Carrington, A. L., Faragher, B., Kulkarni, J., Van Ross, E. R. E., Boulton, A. J. M., Armstrong, D. G., Hadi, S., Nguyen, H. C., Harkless, L. B., Jirkovská, A., Kasalicky, P., Hosová, J., Skibova, J., Uccioli, L., Caselli, A., Giacomozzi, C., Macellari, V., Giurato, L., Lardieri, L., Menzinger, G., Pham, H. T., Rosenblum, B. I., Lyons, T. E., Giurini, J. M., Smakowski, P., Chrzan, J. S., Habershaw, G. M., Veves, A., Foster, A. M., Bates, M., Doxford, M., Edmonds, M. E., Kecha, O., Winkler, R., Martens, H., Collette, J., Lefèbvre, P. J., Greiner, D., Geenen, V., Atlan-Gepner, C., Naspetti, M., Valéro, R., Barad, M., Lepault, F., Vialettes, B., Naquet, P., de Galan, B., Netea, M. G., Hancu, N., Smits, P., Van der Meer, J. W. M., Osterbye, T., Jørgensen, K. H., Tranum-Jensen, J., Fredman, P., Høy, M., Bokvist, K., Olsen, H. 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- 1999
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33. Hexokinase and glucokinase activity in cross-linked and permeabilized pancreatic islets
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Vanhoutte, C., Fernandez-Alvarez, J., Malaisse-Lagae, F., and Malaisse, W. J.
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- 1996
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34. Organelle distribution in chick neuroepithelial cells: Effects of colchicine and cytochalasin B
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Fernandez Alvarez, J. G., Paz, P., and Cesar Chamorro
35. An Overview of Factors Associated with Adherence and Dropout to Ecological Momentary Assessments in Depression
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Colombo, D., Cipresso, P., Fernandez Alvarez, J., Garcia Palacios, A., Riva, G., Cristina Botella, and This work was supported by the Marie Curie EF-ST AffecTech Project, approved at call H2020 – MSCA – ITN – 2016 (project reference: 722022)
- Subjects
Adherence,Dropout,Ecological momentary assessment,Major depressive disorder,MHealth ,major depressive disorder ,mHealth ,Adherence ,Dropout ,ecological momentary assessment ,Ecological Momentary Assessment ,Major Depressive Disorder ,Settore M-PSI/01 - PSICOLOGIA GENERALE ,Major depressive disorder ,adherence ,MHealth ,dropout ,Ecological momentary assessment - Abstract
The use of technology-based Ecological Momentary Assessments (EMAs) allows to repeatedly assess patients during daily life, in naturalistic settings and in precise moments of the day. To date, EMAs have been broadly adopted for the investigation of Major Depressive Disorder (MDD). Nevertheless, adherence still represents a clinical challenge, as depressed patients may be less prone to regularly complete daily reports. Through a systematic narrative review, we qualitatively investigated factors affecting adherence and dropout of MDD patients to EMA protocols. The mean adherence rate across studies was generally encouraging (mean: 80.66%, SD 11.71%), and was higher in studies collecting self-reports by means of smartphones, prompting patients less than 8 times per day and using a prefixed sampling method. Dropouts were mainly related to technical problems or under-threshold number of collected answers, often occurring in studies collecting data by means of Personal Digital Assistants (PDAs). The implications of these results are discussed. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 722022, This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 722022
36. 35th Annual Meeting of the European Association for the Study of Diabetes : Brussels, Belgium, 28 September-2 October 1999
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Melander, A., Olsson, J., Lindberg, G., Salzman, A., Howard, T., Stang, P., Lydick, E., Emslie-Smith, A., Boyle, D. I. R., Evans, J. M. M., Macdonald, T. M., Bain, J., Sullivan, F., Ad Darts Memo, Morris For The Collaboration, Juhl, C., Porksen, N., Sturis, J., Hollingdal, M., Pincus, S., Veldhuis, J., Dejgaard, A., Schmitz, O., Kristensen, J. S., Frandsen, K. B., Bayer, Th, Muller, P., Dunning, B. E., Paladini, S., Gutierrez, C., Deacon, R., Valentin, M., Grunberger, G., Weston, W. M., Patwardhan, R., Rappaport, E. B., Sargeant, L. A., Wareham, N. J., Khaw, K. T., Zethelius, Bjorn, Lithell, Hans, Hales, C. Nicholas, Berne, Christian, Lakka, H-M, Oksanen, L., Tuomainen, T-P, Kontula, K., Salonen, J. T., Dekker, J. M., Boks, P., Vegt, F., Stehouwer, C. D. A., Nijpels, G., Bouter, L. M., Heine, R. J., Bruno, G., Cavallo-Perin, P., Bargero, G., D Errico, N., Borra, M., Macchia, G., Pagano, G., Newton, R. W., Ruta, D. A., New, J. P., Wallace, C., Roxburgh, M. A., Young, R. J., Vaughan, N. J. A., Elliott, P., Brennan, G., Devers, M., Macalpine, R., Steinke, D., Lawson, D. H., Decallonne, B., Casteels, K., Gysemans, C., Bouillon, R., Mathieu, C., Linn, Thomas, Strate, Christine, Schneider, Kerstin, Funda, D. P., Jirsa, M. Jr, Kozakova, H., Kaas, A., Kofronova, O., Tlaskalova-Hogenova, H., Buschard, K., Wanka, H., Hartmann, A., Kuttler, B., Rasmussen, S. B., Sorensen, T. S., Markholst, H., Petersen, J. S., Karounos, D., Dyrberg, T., Mabley, J. G., Hasko, G., Szabo, C., Seissler, J., Nguyen, T. B. T., Steinbrenner, H., Scherbaum, W. A., Cipriani, R., Gabriele, A., Sensi, M., Guidobaldi, L., Pantellini, F., Cerrito, M. G., Scarpa, S., Di Mario, U., Morano, S., Ceolotto, G., Iori, E., Baritono, E., Del Prato, S., Semplicini, A., Trevisan, R., Zerbini, G., Meregalli, G., Asnaghi, V., Tentori, F., Maestroni, A., Mangili, R., Marescotti, C., Vedovato, M., Tiengo, A., Tadjieva, J., Mankovsky, B. N., Aken, S., Raes, A., Vande Walle, J., Matthys, D., Craen, M., Hansen, H. 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V., Jarvis, W. R., Archibald, L. K., Corcoran, S., Mansell, J., Pibworth, L., Terada, H., Shiba, T., Utugi, N., Utugi, T., Blum, M., Strobel, J., Hoffken, K., Razvi, F. M., Kritzinger, E. E., Taylor, K., Jones, S., Illahi, W., Grubetaer, M., Hartmann, P., Hoffstadt, K., Leiden, H. A., Moll, A. C., Polak, B. C. P., Pietragalla, G. B., Maurino, M., Montanaro, M., Karadeniz, S., Tommasini, P., Quadrini, C., Demiraj, V., Rispoli, E., Ota, A., Takama, H., Saito, N., Hemandez, C., Lepore, D., Antico, L., Giardina, B., Franconi, F., Michoud, E., Chamot, S., Riva, Ch, Hammes, H-P, Renner, O., Breier, G., Lin, J., Alt, A., Betzholtz, C., Bretzel, R. G. Rd, Manti, R., Gallo, M., Molinar Hin, A., Brignardello, E., Boccuzzi, G., Li, Shanfang, Xiang, Kunsan, Zhang, Rugeng, Shangguan, Xinhong, Wu, Jianrong, Donnan, P. T., Broomhall, J., Hunter, K., Morris, A. 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37. Intracellular distribution of yolk droplets, lipid bodies and Golgi apparatus in the chick neuroepithelial cells during neurulation
- Author
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Fernandez-Alvarez, J. G., Paulino de Paz, Chamorro, C. A., Fernandez-Caso, M., and Villar, J. M.
38. Delamination of neuroepithelium and nonneural ectoderm and its relation to the convergence step in chick neurulation
- Author
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Fernandez Caso, M., Paulino de Paz, Fernandez Alvarez, J. G., Chamorro, C., and Villar, J. M.
39. Observaciones en el punto de uni�n neuroectodermo-ectodermo no neural en embriones de pollo en neurulaci�n tratados con citocalasina B ?in ovo?
- Author
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Fernandez-Caso, M., primary, Fernandez-Alvarez, J. G., additional, Chamorro, C. A., additional, Paz, P. de, additional, and Villar, J. M., additional
- Published
- 1987
- Full Text
- View/download PDF
40. Nuclear response of pancreatic islets to interleukin-1
- Author
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Fernandez-Alvarez, J., Tomas, C., Casamitjana, R., and Gomis, R.
- Published
- 1994
- Full Text
- View/download PDF
41. Using virtual reality to target positive autobiographical memory in individuals with moderate-to-moderately severe depressive symptoms: A single case experimental design
- Author
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Azucena García Palacios, Giuseppe Riva, Desirée Colombo, Alice Chirico, Carlos Suso-Ribera, Silvia Serino, Daniele Di Lernia, Javier Fernández-Álvarez, Cristina Botella, Fernandez-Alvarez, J, Colombo, D, Suso-Ribera, C, Chirico, A, Serino, S, Di Lernia, D, García Palacios, A, Riva, G, and Botella, C
- Subjects
Overgeneral memory ,050103 clinical psychology ,single case study ,Health Informatics ,Information technology ,Single-subject design ,Virtual reality ,03 medical and health sciences ,0302 clinical medicine ,Reminiscence ,Intervention (counseling) ,Psychology ,Settore M-PSI/01 - PSICOLOGIA GENERALE ,0501 psychology and cognitive sciences ,030212 general & internal medicine ,Depression (differential diagnoses) ,reminiscence ,Recall ,Autobiographical memory ,overgeneral memory ,05 social sciences ,autobiographical memory ,T58.5-58.64 ,Single case study ,Full length Article ,BF1-990 ,Multiple baseline design ,virtual reality ,Brief intervention ,M-PSI/01 - PSICOLOGIA GENERALE ,Clinical psychology - Abstract
So far, several aspects of autobiographical memory (AM) have been found to be impaired in depression. Among others, depressed patients show the tendency to recall more negative than positive events (i.e., negative bias) and usually retrieve memories that lack of specificity and details (i.e., overgeneral memories). Based on this, we designed an AM task enhanced by the use of virtual reality (VR) to specifically train the recall of positive memories. Using a single-case, multiple baseline experimental design, we explored the effects of a brief intervention consisting of two sessions of this training in a sample of 18 individuals with moderate-to-moderately severe depressive symptoms. According to the results, changes occurred at the short term only. In particular, almost all participants reported a significant improvement in at least one outcome measure 0–3 days after the intervention. However, these clinical gains were not maintained in the mid-term (from day 4 to 10). The present findings do not support the efficacy of our VR-based AM recall treatment as a standalone intervention. Nevertheless, it might represent a suitable procedure to obtain immediate and/or short-term improvements. It might also serve as a valid component to be integrated in broader protocols for patients with moderate-to-moderately severe depressive symptoms., Highlights • There is increasing evidence supporting the association between depression and autobiographical memory impairments. • Addressing memory impairments represents a useful therapeutic tool for the treatment of depression. • Virtual reality could enhance the retrieve of positive events, thus making it a good candidate in memory interventions. • After the training, all participants reported a significant improvement in at least one outcome measure. • This training may be a suitable procedure to obtain immediate and/or brief-term improvements.
- Published
- 2020
42. Insulin and glucagon secretion in isolated pancreatic islets from rats with CCL4-induced cirrhosis
- Author
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Fernández-Alvárez, J, Pizcueta, P, Gomis, R, Tomás, C, Casamitjana, R, Bosch, J, and Rodés, J
- Published
- 1989
- Full Text
- View/download PDF
43. Study of the accuracy of a radial arterial pressure waveform cardiac output measurement device after cardiac surgery.
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Ordoñez-Rufat P, Mancho-Fora N, Tebe-Cordomi C, Polit-Martinez V, Abellan-Lencina R, Fernandez-Alvarez J, and Lopez-Delgado JC
- Subjects
- Humans, Aged, Cardiac Output, Monitoring, Intraoperative, Coronary Artery Bypass, Reproducibility of Results, Arterial Pressure, Cardiac Surgical Procedures
- Abstract
Background: Less invasive monitoring, such as radial arterial pulse contour analysis (ProAQT® sensor), represents an alternative when hemodynamic monitoring is necessary to guide postoperative management and invasive monitoring is not technically feasible. The aim of the study is to evaluate the accuracy of the ProAQT® sensor cardiac output measurements in comparison with Pulmonary Artery Catheter (PAC) during the postoperative course of patients who underwent cardiac surgery with cardiopulmonary bypass., Case Presentation: Prospective observational study in a Surgical Intensive Care Unit of a tertiary university hospital. Ten patients with a mean age of 73.5 years were included. The main comorbidities were hypertension, diabetes, dyslipidemia and the preoperative left ejection fraction was 43.8 ± 14.5%. Regarding the type of surgery, six patients underwent valve surgery, two underwent coronary artery bypass grafting and two underwent aortic surgery. The cardiac index measured simultaneously by the ProAQT® sensor was compared with the PAC. The parameters were evaluated at predefined time points during the early postoperative courses (6 h, 12 h, 24 h, 48 h and 72 h). The degree of agreement with the cardiac index between the PAC and the ProAQT® sensor along the time points was measured using the concordance correlation coefficient, Bland-Altman analysis, and four-quadrant plot. Sixty-three pairs of measurements were analyzed. We showed that measurements of cardiac index were slightly higher with PAC (β ̂ = - 0.146, p-value = 0.094). The concordance correlation coefficient for the additive model of cardiac index was 0.64 (95% Confidence Interval: 0.36, 0.82), indicating a high concordance between both sensors. Bland-Altmann analysis showed a mean bias of 0.45 L·min
-1 ·m-2 , limits of agreement from - 1.65 to 2.3 L·min-1 ·m-2 , and percentage of error was 82.5%. Four-quadrant plot of changes in cardiac index showed a good concordance rate (75%), which increases after applying the exclusion zone (87%)., Conclusions: In patients undergoing cardiac surgery, the ProAQT® sensor may be useful to monitor cardiac index during the postoperative period, especially when more invasive monitoring is not possible., (© 2023. The Author(s).)- Published
- 2023
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- View/download PDF
44. Using virtual reality to target positive autobiographical memory in individuals with moderate-to-moderately severe depressive symptoms: A single case experimental design.
- Author
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Fernandez-Alvarez J, Colombo D, Suso-Ribera C, Chirico A, Serino S, Di Lernia D, Palacios AG, Riva G, and Botella C
- Abstract
So far, several aspects of autobiographical memory (AM) have been found to be impaired in depression. Among others, depressed patients show the tendency to recall more negative than positive events (i.e., negative bias) and usually retrieve memories that lack of specificity and details (i.e., overgeneral memories). Based on this, we designed an AM task enhanced by the use of virtual reality (VR) to specifically train the recall of positive memories. Using a single-case, multiple baseline experimental design, we explored the effects of a brief intervention consisting of two sessions of this training in a sample of 18 individuals with moderate-to-moderately severe depressive symptoms. According to the results, changes occurred at the short term only. In particular, almost all participants reported a significant improvement in at least one outcome measure 0-3 days after the intervention. However, these clinical gains were not maintained in the mid-term (from day 4 to 10). The present findings do not support the efficacy of our VR-based AM recall treatment as a standalone intervention. Nevertheless, it might represent a suitable procedure to obtain immediate and/or short-term improvements. It might also serve as a valid component to be integrated in broader protocols for patients with moderate-to-moderately severe depressive symptoms., Competing Interests: The authors declare that there is no conflict of interest., (© 2021 The Authors.)
- Published
- 2021
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- View/download PDF
45. Savoring the present: The reciprocal influence between positive emotions and positive emotion regulation in everyday life.
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Colombo D, Pavani JB, Fernandez-Alvarez J, Garcia-Palacios A, and Botella C
- Subjects
- Adult, Expressed Emotion, Female, Happiness, Humans, Male, Pleasure, Spain, Young Adult, Activities of Daily Living psychology, Adaptation, Psychological, Emotions, Mindfulness, Optimism
- Abstract
A growing body of research has investigated the regulation of negative emotions in ecological settings, but little is known about the mechanisms underlying positive emotion regulation in everyday life. Although some evidence suggests that adopting positive strategies is beneficial for emotional well-being, the literature is inconsistent about the effects of positive emotions on subsequent regulatory processes. In the present study, we adopted a two-week ecological momentary assessment to explore the association between positive emotions and positive emotion regulation in daily life. According to our results, the less individuals felt positive emotions at one point, the more they tended to enhance their use of positive strategies from this time to the next, which in turn resulted in subsequent higher levels of positive emotions. This prototype of positive regulation can be seen as a highly adaptive mechanism that makes it possible to compensate for a lack of positive emotions by enhancing the deployment of positive strategies. The theoretical and clinical implications of these findings are discussed., Competing Interests: The authors have declared that no competing interests exist.
- Published
- 2021
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46. [Pitfalls in the diagnosis of congenital hyperinsulinism: a case report and review of the literature].
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Fernandez Alvarez JR, Rabe H, Wilichowski E, and Pekrun A
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- Diagnostic Errors, Diazoxide therapeutic use, Dominance, Cerebral physiology, Female, Glutamate Dehydrogenase deficiency, Humans, Hyperinsulinism drug therapy, Infant, Epilepsies, Partial diagnosis, Hyperinsulinism diagnosis, Hyperinsulinism genetics, Hypoglycemia diagnosis, Hypoglycemia genetics
- Abstract
Background: Congenital hyperinsulinism is the most common cause for recurrent hypoglycaemia in neonates and infants. Uncontrolled hypoglycaemia leads to seizures and long-term cerebral damage. Often, the diagnosis is delayed because of nonspecific symptoms and confusing laboratory results., Patient: We report a patient with hyperinsulinism who was initially wrongly diagnosed as having idiopathic cerebral convulsions and treated accordingly., Conclusions: Diagnosis of congenital hyperinsulinism is based on a strong suspicion and a thorough family history. Normal random blood glucose or random insulin levels are not helpful in excluding this disease.
- Published
- 2006
- Full Text
- View/download PDF
47. Can treatment with somatostatin analogs replace neurosurgery?
- Author
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Lorenzo-Solar M, Castro A, Peino R, Fernandez-Alvarez J, Dieguez C, and Casanueva FF
- Subjects
- Adenoma pathology, Drug Costs, Health Care Costs, Humans, Pituitary Neoplasms pathology, Postoperative Complications, Acromegaly drug therapy, Acromegaly surgery, Neurosurgical Procedures economics, Somatostatin analogs & derivatives
- Abstract
There is an ongoing controversy on first-line treatment in acromegaly. Although transsphenoidal surgery has always traditionally been considered the first option, the evolution of new medical treatments is now challenging the clinical paradigm. In fact, somatostatin analogs are highly effective, convenient, avoid the growth of tumors or even shrink them, and also have the advantage of preserving normal pituitary function. On the other hand, when successful, neurosurgery has the advantage of eliminating long-term medical treatment and is less expensive. This manuscript discusses the pros and cons of both treatments.
- Published
- 2005
48. P2 receptor agonists stimulate insulin release from human pancreatic islets.
- Author
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Fernandez-Alvarez J, Hillaire-Buys D, Loubatières-Mariani MM, Gomis R, and Petit P
- Subjects
- Adult, Glucose pharmacology, Humans, Insulin Secretion, Islets of Langerhans metabolism, Male, Middle Aged, Radioimmunoassay, Receptors, Purinergic P2X, Receptors, Purinergic P2Y1, Adenosine Diphosphate analogs & derivatives, Adenosine Diphosphate pharmacology, Adenosine Triphosphate analogs & derivatives, Adenosine Triphosphate pharmacology, Insulin metabolism, Islets of Langerhans drug effects, Purinergic P2 Receptor Agonists, Thionucleotides pharmacology
- Abstract
Although P2 receptors for adenosine 5'-triphosphate (ATP) and/or adenosine 5'-diphosphate (ADP) have been characterized in mammalian pancreatic beta cells, no evidence for an insulin-secreting effect of P2 receptor agonists has been reported as yet in humans. The present study aimed at investigating whether P2 receptor agonists could stimulate insulin release in human pancreatic islets obtained from brain-dead organ donors. Experiments were performed using different glucose concentrations and insulin was measured by radioimmunoassay. When the glucose concentration (8.3 mmol/L) was slightly stimulating for insulin release, alpha,beta-methylene ATP (200 micromol/L) and ADPbetaS (50 micromol/L) similarly amplified insulin secretion: both compounds induced a threefold increase in insulin response. In the presence of a nonstimulating glucose concentration (3.0 mmol/L), only alpha,beta-methylene ATP could induce a significant 1.4-fold increase in insulin release, ADPbetaS being completely ineffective. These results give evidence that P2 receptor agonists are effective in stimulating insulin release in humans, the effect of the P2Y agonist being essentially glucose dependent.
- Published
- 2001
- Full Text
- View/download PDF
49. Dexamethasone-induced changes in FAD-glycerophosphate dehydrogenase mRNA, content and activity, and insulin release in human pancreatic islets.
- Author
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Fabregat ME, Fernandez-Alvarez J, Franco C, Malaisse WJ, and Gomis R
- Subjects
- Adult, Aged, Blotting, Northern, Blotting, Western, Female, Flavin-Adenine Dinucleotide metabolism, Glycerolphosphate Dehydrogenase metabolism, Humans, Insulin Secretion, Islets of Langerhans drug effects, Islets of Langerhans ultrastructure, Middle Aged, Mitochondria enzymology, Dexamethasone pharmacology, Glucocorticoids pharmacology, Glycerolphosphate Dehydrogenase genetics, Insulin metabolism, Islets of Langerhans metabolism, RNA, Messenger metabolism
- Abstract
Human pancreatic islets were cultured for 63 hr at 2.8 or 16.7 mM D-glucose in the absence or presence of dexamethasone. In the 1.0 to 10 microM range, dexamethasone caused a concentration-related decrease in the FAD (flavin adenine dinucleotide)-linked mitochondrial glycerophosphate dehydrogenase (mGDH) mRNA content of the islets, and decreased both the mGDH content of the islets and the catalytic activity of the enzyme in islet homogenates, these effects being often more marked in islets cultured at 16.7 mM, rather than 2.8 mM, D-glucose. Even after culture in the presence of no more than 10 nM dexamethasone, namely under conditions in which the mGDH mRNA content and activity were both virtually unaffected, the corticosteroid restored the capacity of the beta-cells to display an increase in insulin output in response to a rise in D-glucose concentration in islets first cultured at 2.8 mM D-glucose but suppressed the insulinotropic action of the hexose in islets first cultured at 16.7 mM D-glucose. Whilst revealing an untoward effect of high concentrations of dexamethasone upon mGDH mRNA, content and activity in human islets, these findings also document a dual effect of a low concentration of the corticosteroid (10 nM) upon the secretory responsiveness of human islets to D-glucose, independently of any significant change in mGDH gene expression. It is proposed that such a dual action may account, in part at least, for both the well known increase in insulin output found in hypercorticism and the more recently discovered unfavourable direct effect of corticosteroid hormones on the secretory activity of islet beta-cells.
- Published
- 1999
50. Effect of high glucose concentration on proinsulin biosynthesis and conversion by human islets.
- Author
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Usac EF, Nadal B, Gasa R, Fernandez-Alvarez J, and Gomis R
- Subjects
- Aged, Blotting, Western, Cells, Cultured, Culture Media, Female, Humans, Islets of Langerhans cytology, Male, Middle Aged, Proinsulin biosynthesis, Glucose pharmacology, Insulin biosynthesis, Islets of Langerhans metabolism, Proinsulin metabolism
- Abstract
In the present study we investigate whether glucose concentration could have an effect on proinsulin biosynthesis and processing. We cultured control human islets under chronic high and low glucose concentrations. After the culture period, islets were pulse-labeled and chased for different periods of time. Proteins from islets were collected, insulin immunoprecipitated, and analyzed by alkaline-urea gel electrophoresis. We have found an accelerated rate of proinsulin conversion by those islets exposed to high glucose concentration (at 24.4 mM of glucose), but not by those islets cultured at low glucose concentration (at 5.5 mM of glucose). However, we do not observe any decrease or increase on newly proinsulin synthesis in any of these conditions.
- Published
- 1998
- Full Text
- View/download PDF
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