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15 results on '"Fernandez Campos, Francisco"'

12. Amoxicillin and Clarithromycin Mucoadhesive Delivery System for Helicobacter pylori Infection in a Mouse Model: Characterization, Pharmacokinetics, and Efficacy

Author

Villegas, Isabel, primary, Rosillo, María Ángeles, additional, Alarcón-de-la-Lastra, Catalina, additional, Vázquez-Román, Victoria, additional, Llorente, Maria, additional, Sánchez, Susana, additional, Gil, Ana Gloria, additional, Alcalde, Pilar, additional, González, Esther, additional, Rosell, Elisabet, additional, Nieto, Carles, additional, and Fernandez-Campos, Francisco, additional

Published
2021
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13. In situ bioadhesive film-forming system for topical delivery of mometasone furoate: Characterization and biopharmaceutical properties

Author

Fernandez-Campos Francisco, González Plágaro Jordi, and Labella-Lorite Monica

Subjects
chemistry.chemical_classification, Materials science, Bioadhesive, Plasticizer, Pharmaceutical Science, Mometasone furoate, 02 engineering and technology, Polymer, Permeation, 021001 nanoscience & nanotechnology, 030226 pharmacology & pharmacy, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Biopharmaceutical, chemistry, Drug delivery, medicine, Methyl methacrylate, 0210 nano-technology, medicine.drug, Biomedical engineering
Abstract

In situ film-forming systems (FFS) are attractive drug delivery systems employed for the topical administration of drugs. They are transparent and have high substantivity and improved cosmetic attributes. Two types of polymeric materials, methyl methacrylate and cellulosic derivates, were employed for the topical delivery of mometasone furoate. A previous screening of polymers and plasticizers was performed to select the best candidates based on cosmetic characteristics. Water vapor permeability determines the occlusive profile, and it has been observed that it depends on the polymer type. The rheological, bioadhesion, and mechanical properties of the films revealed that the best candidates were Eudragit S100 and HPMC films. These polymers also exhibited the slowest drug release and limited permeation across the skin, with no alteration in the microstructure of the skin layers after diffusion experiments. Both FFS were adequate to improve patient compliance with treatment due to the cosmetic attractiveness and a potential reduction in administration frequency. They also potentially allow for administration to high-friction areas and the face.

Published
2020
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15. Pharmaceutical design of a new lactose-free coprocessed excipient: application of hydrochlorothiazide as a low solubility drug model.

Author

Viscasillas Clerch, Anna, Fernandez Campos, Francisco, del Pozo, Alfonso, and Calpena Campmany, Ana Cristina

Subjects
DRUG design, DRUG solubility, EXCIPIENTS, DRUG tablets, LACTOSE intolerance, CALCIUM phosphate, BIOPHARMACEUTICS, PHARMACOKINETICS
Abstract

Most co-processed excipients used in direct-compression tablets contain lactose, which prevents lactose-intolerant patients from taking such tablets. Therefore, a novel lactose-free co-processed excipient for direct compression tablets has been prepared. Microcrystalline cellulose and dicalcium phosphate dehydrate were used as primary excipients which underwent a wet granulation process and factorial experiment in order to ascertain the best prototype. Finally, the best two prototypes were added to hydrochlorothiazide, which has chosen as the model drug because of its low solubility. An extensive characterization of the new excipient as well as the drug loaded tablets is reported. Our results show adequate parameters (rheological and compression behavior, uniformity of weight, disintegration, friability, crushing force and cohesion index). Moreover, the biopharmaceutical profile was evaluated; the tablets exhibits a Weibull kinetic function and fast drug release. [ABSTRACT FROM AUTHOR]

Published
2013
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