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Over the last 75 years, significant shifts in dietary patterns have mirrored the rise of non-communicable diseases, which account for approximately 75% of deaths in developed countries. Cardiometabolic diseases (CMD) remain the leading cause of death globally, with disparities particularly evident among various racial/ethnic minority groups in the United States (US) . These disparities are highly impacted by the Modern Western Diet (MWD), differential nutrient metabolism, and destructive gene-diet interactions. A decade of nutrigenomics research has highlighted how ancestry-related genetic variation interacts with the consumption of 18-carbon (18C) essential omega-6 and -3 polyunsaturated fatty acids (n-6 PUFA and n-3 PUFA), to influence molecular and clinical biomarkers. Specifically, variations in the fatty acid desaturases (FADS1/2/3) cluster, crucial for determining the efficiency for converting dietary 18C alpha-linolenic acid (ALA) and linoleic acid (LA) into long chain (>=20) highly unsaturated fatty acids (HUFA), are linked to levels of cardiometabolic (CMD) markers. These genetic variations alter the balance of n-6 and n-3 HUFAs and the production of their respective bioactive oxylipins. Previous research established that African-ancestry populations primarily carry two copies of variants linked to the FADS “derived” haplotype (DH) associated with the efficient conversion of 18C PUFA to HUFAs. The "ancestral" haplotype (AH), linked to reduced conversion capacity is prevalent in Hispanic Americans and nearly fixed in Indigenous American populations. This dissertation investigates the impact of FADS and elongase (ELOVL5/2, responsible for PUFA and HUFA elongation) variants on CMD risk in Latinos of Mexican Ancestry (LAM) and American Indians (AI), employing regression models with covariate adjustments to explore associations between genotypes and PUFAs, HUFAs and CMD markers. Individuals carrying two copies of AH variants (~50% in LAM and ~78% in AI) exhibite

Study design, case-control study: Background, Morton’s extension (ME) is a kind of orthotic that has been used as a conservative treatment of painful hallux rigidus (HR) osteoarthritis, but only their effects on first metatarsophalangeal joint (MPJ) mobility and position in healthy subjects have been studied, but not on its applied pulled tension forces neither in subjects with HR. Objectives: This study sought to understand how ME’s orthotics with three different thicknesses could influence the kinematic first MPJ by measuring hallux dorsiflexion using Jack’s test and a digital algometer with a rigid strip anchored to the iron hook’s extremity and comparing subjects with healthy first MPJ mobility to those with HR.We aimed to clarify whether tension values were different between healthy and HR subjects. Methods: Fifty-eight subjects were selected, of whom thirty were included in the case group according to HR criteria and twenty-eight were included in the control group. A digital algometer (FPX®® 25,Wagner Instruments®®, Greenwich, CT, USA) was used to assess the pulled tension values (kgf) of the first MPJ during Jack’s test. Results: The pulled tension values were highly reliable (ICC > 0.963). There were no statistically significant differences between the pulled tension values for the different ME conditions in the case (p = 0.969) or control (p = 0.718) groups. However, as it’s expected, there were statistically significant differences comparing all pulled tension values between case and control group subjects (p < 0.001). Conclusions: Different ME’s thicknesses had no influence on the pulled effort applied during the dorsiflexion Jack’s test between the healthy and HR groups; therefore, it can be prescribed without joint-care danger. In addition, it is proven that there is greater resistance to performing Jack’s test in the HR group than in the healthy group, regardless of ME’s orthotics. Furthermore, it is shown that the digital algometer device is a valid t, Fac. de Enfermería, Fisioterapia y Podología, TRUE, pub

El proyecto CONTRIVE-UCM se basa en crear una herramienta digital en línea que permita transformar la gestión de la calidad e innovación dentro de la Facultad de Enfermería, Fisioterapia y Podología (FEFyP) hacia un modelo virtual, mediante la captación de ideas por parte de todo el personal del centro involucrando tanto docentes como estudiantes, con el fin de democratizar y mejorar la transparencia de los programas formativos, los procesos de calidad, a través de la participación activa en el uso de la herramienta digital como experiencia innovadora.