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2 results on '"Fernandes ALM"'

1. Cerebral Vascular Accident in Young Women: A Problem for Pregnancy and Contraception? Report of Two Cases

Author

Zimmermann Jb, Barbosa Inl, Pacheco Gan, Sant-Ana Gmc, Pinto Cdc, Fonseca Cc, Faria Lp, Barreto Ic, Fernandes Alm, Silva Lff, Mata Ds, Mourão Pa, Amaral Vm, Resende Laf, Gribel Lh, Araujo Ahsl, Caplum Mc, and Luz Ms

Subjects
medicine.medical_specialty, Disease, Case Reports, 030204 cardiovascular system & hematology, Thrombophilia, Preeclampsia, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Ischemic, medicine, Eclampsia, Stroke, Hemorrhagic, business.industry, Obstetrics, Incidence (epidemiology), Asploro Journal of Biomedical and Clinical Case Reports, General Medicine, medicine.disease, Cerebrovascular Disease, Gestation, business, 030217 neurology & neurosurgery
Abstract

Cerebrovascular disease (CVD) is a neurological medical emergency and one of the main causes of death worldwide; it is classified as ischemic or hemorrhagic. The disease is one of the most severe clinical events related to pregnancy due to thrombogenesis and thrombophilia; there is an incidence of 25 to 34 CVD per 100 thousand births. The current research reports two cases of stroke episode, one previous and another during pregnancy, as well as their associated complications. The first patient had hereditary thrombophilia caused by PAI 4G/5G polymorphism and previous stroke; however, she had regular pregnancy. The second patient had hereditary thrombophilia caused by protein C deficit, had a stroke during pregnancy, and preeclampsia in the first gestational semester; therefore, she was subjected to the cesarean section on the 35thweek of pregnancy. Stroke episodes during pregnancy can be very aggressive because it can lead to death or disabilities, not only in the mother but also in the fetus. Based on the association between thrombotic processes and complications, prophylactic anticoagulant therapy is recommended for women with thrombophilia who had a stroke and/or certain adverse pregnancy outcomes, such as recurrent miscarriages.

Published
2020

2. Association of PTX3 gene polymorphisms and PTX3 plasma levels with leprosy susceptibility.

Author

Moraes ACCG, da Luz RCFV, Fernandes ALM, Barbosa MXS, de Andrade LV, Armstrong ADC, de Souza CDF, and do Carmo RF

Subjects
Humans, Drug Therapy, Combination, C-Reactive Protein genetics, C-Reactive Protein analysis, Biomarkers, Polymorphism, Single Nucleotide, Leprostatic Agents, Leprosy genetics
Abstract

Background: Pentraxin 3 (PTX3) is a soluble pattern recognition receptor that plays a crucial role in modulating the inflammatory response and activating the complement system. Additionally, plasma PTX3 has emerged as a potential biomarker for various infectious diseases. The aim of this study was to evaluate the association of PTX3 gene polymorphisms and PTX3 plasma levels with susceptibility to leprosy and clinical characteristics., Methods: Patients with leprosy from a hyperendemic area in the Northeast Region of Brazil were included. Healthy household contacts and healthy blood donors from the same geographical area were recruited as a control group. The rs1840680 and rs2305619 polymorphisms of PTX3 were determined by real-time PCR. Plasma levels of PTX3 were determined by ELISA., Results: A total of 512 individuals were included. Of these, 273 were patients diagnosed with leprosy; 53 were household contacts, and 186 were healthy blood donors. No association was observed between PTX3 polymorphisms and susceptibility to leprosy or development of leprosy reaction or physical disability. On the other hand, plasma levels of PTX3 were significantly higher in patients with leprosy when compared to household contacts (p = 0.003) or blood donors (p = 0.04). It was also observed that PTX3 levels drop significantly after multidrug therapy (p < 0.0001)., Conclusions: Our results suggest that PTX3 may play an important role in the pathogenesis of leprosy and point to the potential use of this molecule as an infection marker., (© 2023. The Author(s).)

Published
2023
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