14 results on '"Fernandes, Natália C. C. A."'
Search Results
2. Benign Peripheral Nerve Sheath Tumor in a Wild Toco Toucan (Ramphastos toco)
- Author
-
Carvalho, Marcelo P. N., Fernandes, Natalia C. C. A., Nemer, Viviane C., Neto, Ramiro N. Dias, Teixeira, Rodrigo H. F., Miranda, Bruna S., Mamprim, Maria J., Catão-Dias, José L., and Réssio, Rodrigo A.
- Published
- 2016
3. Supplemental Material, sj-pdf-1-vet-10.1177_03009858211009781 - Yellow Fever as Cause of Death of Titi Monkeys (Callicebus Spp.)
- Author
-
De A. Fernandes, Natália C. C., Cunha, Mariana S., Guerra, Juliana M., Diaz-Delgado, Josué, Ressio, Rodrigo A., Cirqueira, Cinthya S., Kanamura, Cristina T., Fuentes-Castillo, Danny, and Catão-Dias, José Luiz
- Subjects
70706 Veterinary Medicine ,FOS: Clinical medicine ,FOS: Veterinary sciences ,111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified - Abstract
Supplemental Material, sj-pdf-1-vet-10.1177_03009858211009781 for Yellow Fever as Cause of Death of Titi Monkeys (Callicebus Spp.) by Natália C. C. de A. Fernandes, Mariana S. Cunha, Juliana M. Guerra, Josué Diaz-Delgado, Rodrigo A. Ressio, Cinthya S. Cirqueira, Cristina T. Kanamura, Danny Fuentes-Castillo and José Luiz Catão-Dias in Veterinary Pathology
- Published
- 2021
- Full Text
- View/download PDF
4. Yellow Fever as Cause of Death of Titi Monkeys (Callicebus Spp.)
- Author
-
Fernandes, Natália C. C. de A., primary, Cunha, Mariana S., additional, Guerra, Juliana M., additional, Diaz-Delgado, Josué, additional, Ressio, Rodrigo A., additional, Cirqueira, Cinthya S., additional, Kanamura, Cristina T., additional, Fuentes-Castillo, Danny, additional, and Catão-Dias, José Luiz, additional
- Published
- 2021
- Full Text
- View/download PDF
5. Genomic Surveillance of Yellow Fever Virus Epizootic in São Paulo, Brazil, 2016 – 2018
- Author
-
Lauring, Adam S., Hill, Sarah C., de Souza, Renato, Thézé, Julien, Claro, Ingra, Aguiar, Renato S., Abade, Leandro, Santos, Fabiana C. P., Cunha, Mariana S., Nogueira, Juliana S., Salles, Flavia C. S., Rocco, Iray M., Maeda, Adriana Y., Vasami, Fernanda G. S., du Plessis, Louis, Silveira, Paola P., de Jesus, Jaqueline G., Quick, Joshua, Fernandes, Natália C. C. A., Guerra, Juliana M., Réssio, Rodrigo A., Giovanetti, Marta, Alcantara, Luiz C. J., Cirqueira, Cinthya S., Díaz-Delgado, Josué, Macedo, Fernando L. L., Timenetsky, Maria do Carmo S. T., de Paula, Regiane, Spinola, Roberta, Telles de Deus, Juliana, Mucci, Luís F., Tubaki, Rosa Maria, de Menezes, Regiane M. T., Ramos, Patrícia L., de Abreu, Andre L., Cruz, Laura N., Loman, Nick, Dellicour, Simon, Pybus, Oliver G., Sabino, Ester C., and Faria, Nuno R.
- Subjects
parasitic diseases ,geographic locations - Abstract
São Paulo, a densely inhabited state in southeast Brazil that contains the fourth most populated city in the world, recently experienced its largest yellow fever virus (YFV) outbreak in decades. YFV does not normally circulate extensively in São Paulo, so most people were unvaccinated when the outbreak began. Surveillance in non-human primates (NHPs) is important for determining the magnitude and geographic extent of an epizootic, thereby helping to evaluate the risk of YFV spillover to humans. Data from infected NHPs can give more accurate insights into YFV spread than when using data from human cases alone. To contextualise human cases, identify epizootic foci and uncover the rate and direction of YFV spread in São Paulo, we generated and analysed virus genomic data and epizootic case data from NHPs in São Paulo. We report the occurrence of three spatiotemporally distinct phases of the outbreak in São Paulo prior to February 2018. We generated 51 new virus genomes from YFV positive cases identified in 23 different municipalities in São Paulo, mostly sampled from NHPs between October 2016 and January 2018. Although we observe substantial heterogeneity in lineage dispersal velocities between phylogenetic branches, continuous phylogeographic analyses of generated YFV genomes suggest that YFV lineages spread in São Paulo at a mean rate of approximately 1km per day during all phases of the outbreak. Viral lineages from the first epizootic phase in northern São Paulo subsequently dispersed towards the south of the state to cause the second and third epizootic phases there. This alters our understanding of how YFV was introduced into the densely populated south of São Paulo state. Our results shed light on the sylvatic transmission of YFV in highly fragmented forested regions in São Paulo state and highlight the importance of continued surveillance of zoonotic pathogens in sentinel species.
- Published
- 2020
6. Genomic Surveillance of Yellow Fever Virus Epizootic in São Paulo, Brazil, 2016 – 2018
- Author
-
Hill, Sarah C., primary, de Souza, Renato, additional, Thézé, Julien, additional, Claro, Ingra, additional, Aguiar, Renato S., additional, Abade, Leandro, additional, Santos, Fabiana C. P., additional, Cunha, Mariana S., additional, Nogueira, Juliana S., additional, Salles, Flavia C. S., additional, Rocco, Iray M., additional, Maeda, Adriana Y., additional, Vasami, Fernanda G. S., additional, du Plessis, Louis, additional, Silveira, Paola P., additional, de Jesus, Jaqueline G., additional, Quick, Joshua, additional, Fernandes, Natália C. C. A., additional, Guerra, Juliana M., additional, Réssio, Rodrigo A., additional, Giovanetti, Marta, additional, Alcantara, Luiz C. J., additional, Cirqueira, Cinthya S., additional, Díaz-Delgado, Josué, additional, Macedo, Fernando L. L., additional, Timenetsky, Maria do Carmo S. T., additional, de Paula, Regiane, additional, Spinola, Roberta, additional, Telles de Deus, Juliana, additional, Mucci, Luís F., additional, Tubaki, Rosa Maria, additional, de Menezes, Regiane M. T., additional, Ramos, Patrícia L., additional, de Abreu, Andre L., additional, Cruz, Laura N., additional, Loman, Nick, additional, Dellicour, Simon, additional, Pybus, Oliver G., additional, Sabino, Ester C., additional, and Faria, Nuno R., additional
- Published
- 2020
- Full Text
- View/download PDF
7. Molecular, serological, pathological, immunohistochemical and microbiological investigation ofBrucellaspp. in marine mammals of Brazil reveals new cetacean hosts
- Author
-
Sánchez‐Sarmiento, Angélica M., primary, Carvalho, Vitor L., additional, Díaz‐Delgado, Josué, additional, Ressio, Rodrigo A., additional, Fernandes, Natália C. C. A., additional, Guerra, Juliana M., additional, Sacristán, Carlos, additional, Groch, Kátia R., additional, Silvestre‐Perez, Natalia, additional, Ferreira‐Machado, Eduardo, additional, Costa‐Silva, Samira, additional, Navas‐Suárez, Pedro, additional, Meirelles, Ana C. O., additional, Favero, Cintia, additional, Marigo, Juliana, additional, Bertozzi, Carolina P., additional, Colosio, Adriana C., additional, Marcondes, Milton C. C., additional, Cremer, Marta J., additional, Santos Silva, Nairléia, additional, Ferreira Neto, Jose Soares, additional, Keid, Lara B., additional, Soares, Rodrigo, additional, Sierra, Eva, additional, Fernández, Antonio, additional, and Catão‐Dias, José L., additional
- Published
- 2019
- Full Text
- View/download PDF
8. Comparative Immunopathology of Cetacean morbillivirus Infection in Free-Ranging Dolphins From Western Mediterranean, Northeast-Central, and Southwestern Atlantic
- Author
-
Díaz-Delgado, Josué, primary, Groch, Kátia R., additional, Ressio, Rodrigo, additional, Riskallah, Isis P. J., additional, Sierra, Eva, additional, Sacchini, Simona, additional, Quesada-Canales, Óscar, additional, Arbelo, Manuel, additional, Fernández, Antonio, additional, Santos-Neto, Elitieri, additional, Ikeda, Joana, additional, Carvalho, Rafael Ramos de, additional, Azevedo, Alexandre de Freitas, additional, Lailson-Brito, Jose, additional, Flach, Leonardo, additional, Kanamura, Cristina T., additional, Fernandes, Natália C. C. A., additional, Cogliati, Bruno, additional, Centelleghe, Cinzia, additional, Mazzariol, Sandro, additional, Di Renzo, Ludovica, additional, Di Francesco, Gabriella, additional, Di Guardo, Giovanni, additional, and Catão-Dias, José Luiz, additional
- Published
- 2019
- Full Text
- View/download PDF
9. Feline Sporothrix spp. detection using cell blocks from brushings and fine‐needle aspirates: Performance and comparisons with culture and histopathology
- Author
-
Gonsales, Fernanda F., primary, Fernandes, Natália C. C. A., additional, Mansho, Wilson, additional, Montenegro, Hildebrando, additional, Guerra, Juliana M., additional, de Araújo, Leonardo José T., additional, da Silva, Silvana M. P., additional, and Benites, Nilson R., additional
- Published
- 2019
- Full Text
- View/download PDF
10. Differential Yellow Fever Susceptibility in New World Nonhuman Primates, Comparison with Humans, and Implications for Surveillance.
- Author
-
de Azevedo Fernandes, Natalia C. C., Guerra, Juliana M., Díaz-Delgado, Josué, Cunha, Mariana S., Saad, Leila del C., Iglezias, Silvia D., Ressio, Rodrigo A., dos Santos Cirqueira, Cinthya, Kanamura, Cristina T., Jesus, Isis P., Maeda, Adriana Y., Vasami, Fernanda G. S., de Carvalho, Júlia, de Araújo, Leonardo J. T., Pereira de Souza, Renato, Nogueira, Juliana S., Spinola, Roberta M. F., Catão-Dias, José L., de Azevedo Fernandes, Natália C C, and Saad, Leila delC
- Subjects
RESEARCH ,ANIMAL experimentation ,FLAVIVIRUSES ,RESEARCH methodology ,YELLOW fever ,MEDICAL cooperation ,EVALUATION research ,PRIMATES ,COMPARATIVE studies - Abstract
A major outbreak of yellow fever (YF) occurred in Brazil during 2016-2018. Epizootics in New World nonhuman primates are sentinel events for YF virus circulation. However, genus-specific susceptibilities and suitability for YF surveillance remain poorly understood. We obtained and compared epidemiologic, histopathologic, immunohistochemical, and molecular results from 93 human and 1,752 primate cases submitted during the recent YF outbreak in Brazil (2017), with the support of the Brazilian National YF Surveillance Program. We detected heterogeneous YF-associated profiles among the various genera of primates we analyzed. Alouatta primates were the most reliable sentinel; Sapajus and Callicebus primates had higher viral loads but lower proportional mortality rates. Callithrix primates were the least sensitive, showing lower viral loads, lower proportional mortality rates, and no demonstrable YF virus antigen or extensive lesions in liver, despite detectable viral RNA. These differences in susceptibility, viral load, and mortality rates should be considered in strategic surveillance of epizootics and control measures for YF. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
11. Molecular, serological, pathological, immunohistochemical and microbiological investigation of Brucella spp. in marine mammals of Brazil reveals new cetacean hosts.
- Author
-
Sánchez‐Sarmiento, Angélica M., Carvalho, Vitor L., Díaz‐Delgado, Josué, Ressio, Rodrigo A., Fernandes, Natália C. C. A., Guerra, Juliana M., Sacristán, Carlos, Groch, Kátia R., Silvestre‐Perez, Natalia, Ferreira‐Machado, Eduardo, Costa‐Silva, Samira, Navas‐Suárez, Pedro, Meirelles, Ana C. O., Favero, Cintia, Marigo, Juliana, Bertozzi, Carolina P., Colosio, Adriana C., Marcondes, Milton C. C., Cremer, Marta J., and Santos Silva, Nairléia
- Subjects
MARINE mammals ,BRUCELLA ,CETACEA ,AGGLUTINATION tests ,ROSE bengal ,CARNIVORA - Abstract
Summary: Brucella‐exposure and infection is increasingly recognized in marine mammals worldwide. To better understand the epidemiology and health impacts of Brucella spp. in marine mammals of Brazil, molecular (conventional PCR and/or real‐time PCR), serological (Rose Bengal Test [RBT], Competitive [c]ELISA, Serum Agglutination Test [SAT]), pathological, immunohistochemical (IHC) and/or microbiological investigations were conducted in samples of 129 stranded or by‐caught marine mammals (orders Cetartiodactyla [n = 124], Carnivora [n = 4] and Sirenia [n = 1]). Previous serological tests performed on available sera of 27 of the 129 animals (26 cetaceans and one manatee), indicated 10 seropositive cetaceans. Conventional PCR and/or real‐time PCR performed in cases with available organs (n = 119) and/or blood or swabs (n = 10) revealed 4/129 (3.1%) Brucella‐infected cetaceans (one of them with positive serology; the remaining three with no available sera). Pathological, IHC and/or microbiological analyses conducted in PCR/real‐time PCR and/or seropositive cases (n = 13) revealed Brucella‐type lesions, including meningitis/meningoencephalitis, pneumonia, necrotizing hepatitis, pericarditis and osteoarthritis in some of those animals, and positive IHC was found in all of them (excepting two live‐stranded animals without available organs). Brucella spp. culture attempts were unsuccessful. Our results demonstrated exposure, asymptomatic, acute and chronic Brucella sp. infection in several cetacean species in the Brazilian coast, highlighting the role of this pathogen in stranding and/or death, particularly in Clymene dolphin (Stenella clymene) and short‐finned pilot whale (Globicephala macrorhynchus) off Ceará State. Novel hosts susceptible to Brucella included the franciscana (Pontoporia blainvillei), the Guiana dolphin (Sotalia guianensis) and the spinner dolphin (Stenella longirostris). Additionally, three coinfection cases involving Brucella spp. and cetacean morbillivirus, Edwarsiella tarda and Proteus mirabilis were detected. To the best of our knowledge, this is the first long‐term and large‐scale survey of Brucella spp. in marine mammals of South America, widening the spectrum of susceptible hosts and geographical distribution range of this agent with zoonotic potential. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
12. Myeloid and histiocytic sarcomas in subantarctic fur seals Arctocephalus tropicalis, Brazil.
- Author
-
Reisfeld L, Fernandes NCCA, Sarmiento A, Canedo P, Salvagni F, Ewbank AC, Zecchini Barrese T, Cilento Ponce C, Albergaria Ressio R, Catão-Dias JL, and Sacristán C
- Subjects
- Animals, Brazil epidemiology, Caniformia, Fur Seals, Herpesviridae, Histiocytic Sarcoma veterinary
- Abstract
Histopathological and immunohistochemical methods were used to diagnose round cell tumors in 2 subantarctic fur seals Arctocephalus tropicalis with marked anemia. Although wild-born, both individuals were placed under human care while juveniles in a Brazilian aquarium. Both pinnipeds were PCR tested for herpesvirus, and 1 was infected with otariid gammaherpesvirus 5 (OtHV-5), previously described in a subantarctic fur seal stranded in Brazil. Although some gammaherpesviruses can cause sarcomas and other neoplasms, it was not possible to definitively associate OtHV-5 with the neoplasm. To our knowledge, these are the first neoplasm records in subantarctic fur seals.
- Published
- 2022
- Full Text
- View/download PDF
13. Cytokine profile and parasite load in lymph nodes of dogs naturally infected with Leishmania infantum from distinct epidemiological scenarios in São Paulo State, Brazil.
- Author
-
Guerra JM, Fernandes NCCA, Réssio RA, Kimura LM, Barbosa JER, Taniguchi HH, Hiramoto RM, Motoie G, Tolezano JE, and Cogliati B
- Subjects
- Animals, Brazil epidemiology, Dog Diseases epidemiology, Dog Diseases parasitology, Dog Diseases pathology, Dogs, Female, Leishmaniasis, Visceral epidemiology, Leishmaniasis, Visceral immunology, Leishmaniasis, Visceral pathology, Lymph Nodes pathology, Male, Parasite Load, Cytokines immunology, Dog Diseases immunology, Leishmania infantum immunology, Leishmaniasis, Visceral veterinary, Lymph Nodes parasitology
- Abstract
Visceral leishmaniasis (VL) is an important zoonotic vector-borne disease and domestic dogs are considered the main domiciliary and peri-domiciliary reservoir of Leishmania (Leishmania) infantum in South America. Distinct eco-epidemiological scenarios associated to the prevalence of the disease, clusters of parasite genotypes and chemotypes of vectors population are described in Brazil, especially in the state of São Paulo (SP). In this context, the purpose of the present study is to evaluate the clinical signs, histopathological lesions, parasite load and cytokine profile by immunohistochemistry (IHC) in popliteal lymph nodes of canines naturally infected with L. infantum, from different municipalities of the state of SP. Eighty-three dogs with VL, 61 from northwest SP (NWSP) and 22 from southeast SP (SESP), were clinically classified in stage II, with no babesiosis and ehrlichiosis. Subcapsular inflammatory infiltration and histiocytosis were significantly higher in the SESP group (p = 0.0128; 0.0077, respectively). On the other hand, dogs from NWSP revealed 4.6-fold significantly higher parasite burden (p = 0.0004) and higher IHC scores of IL-1β (p = 0.0275) and IL-4 (p = 0.0327) in the popliteal lymph node tissues, which may be associated with the susceptibility and progression of the disease in these dogs. Differences in immune response profile associated with higher parasite load in dogs can also contribute to explain the distinct eco-epidemiological patterns of VL in specific geographic regions., (Copyright © 2021 Elsevier B.V. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
14. Experimental Zika virus infection induces spinal cord injury and encephalitis in newborn Swiss mice.
- Author
-
Fernandes NC, Nogueira JS, Réssio RA, Cirqueira CS, Kimura LM, Fernandes KR, Cunha MS, Souza RP, and Guerra JM
- Subjects
- Animals, Animals, Newborn, Brain pathology, Encephalitis pathology, Female, Male, Mice, Myelitis pathology, Spinal Cord pathology, Disease Models, Animal, Encephalitis virology, Myelitis virology, Zika Virus Infection pathology
- Abstract
A widespread epidemic of Zika virus (ZIKV) infection was reported in 2015 in South and Central America, with neurological symptons including meningoencephalitis and Guillain-Barré syndrome in adults, besides an apparent increased incidence of microcephaly in infants born to infected mothers. It is becoming a necessity to have a trustworthy animal model to better understand ZIKV infection. In this study we used newborn white Swiss mice as a model to investigate the ZIKV strain recently isolated in Brazil. ZIKV was inoculated via intracerebral and subcutaneous routes and analysed through gross histopathology and immunohistochemistry. Here we demonstrated first that the intracerebral group (ICG) displayed severe cerebral lesions, with neuronal death, presence of apoptotic bodies, white matter degeneration and neutrophil perivascular cuffing. In the subcutaneous group (SCG), we observed moderate cerebral lesions, morphologically similar to that found in ICG and additional myelopathy, with architectural loss, marked by neuronal death and apoptotic bodies. Interestingly, we found an intense astrogliosis in brain of both groups, with increased immunoexpression of GFAP (glial fibrillary acidic protein) and presence of hypertrophic astrocytes. The spinal cord of subcutaneous group (SCG) exhibited reduction of astrocytes, but those positive for GFAP were hypertrophic and presented prolonged cellular processes. Finally significant lesions in the central nervous system (CNS) were present in newborn mice inoculated by both routes, but SCG method led to an important neurological manifestations (including myelopathy), during a longer period of time and appears for us to be a better model for ZIKV infection., (Copyright © 2016 Elsevier GmbH. All rights reserved.)
- Published
- 2017
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.