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The current global food system is characterized by anonymity in the value chain, global food trade, loss of knowledge about food sources, and a distant producer-consumer relationship. In addition, the negative environmental impacts of the agricultural sector, such as pollution, degradation of soil and water quality, loss of biodiversity, and significant greenhouse gas emissions, make this sector a major driver of climate change. In contrast, the city region food system (CRFS) approach captures the complexity of a food system and its actors at the local level. It aims to meet the requirements of sustainable transformation along the food value chain and offers an alternative approach to the challenges of the global food system. However, the actors and their relationships in CRFS are rarely analyzed. To fill this gap, this study focuses on analyzing CRFSs as networks using the Net-Map tool to study different CRFS in seven European cities (Bologna, Naples, Lansingerland, Tenerife, Oslo, Dortmund, and Romainville). The aim of this paper is to concentrate on the method and to show how the Net-Map tool can effectively support the evaluation of the CRFS by identifying different actor roles, recognizing patterns of relationships. Additionally, the strengths and weaknesses of the network can be assessed by a strengths, weaknesses, opportunities and threats (SWOT) analysis. The paper highlights the limitations, advantages, and practical use of the Net-Map tool and discusses potential transferability to other case studies.

Primary amoebic meningoencephalitis (PAM) is a central nervous system (CNS) disease caused by Naegleria fowleri that mainly affects children and young adults with fatal consequences in most of the cases. Treatment protocols are based on the combination of different antimicrobial agents, nonetheless there is the need to develop new anti-Naegleria compounds with low toxicity and full effects compared to the currently used drug combination. The marine environment is a well-established source of bioactive natural products. In this work, we have focused on the structure of Laurencia cyclolaurane-type sesquiterpenes as potential chemical model against Naegleria species. The effects of debromolaurinterol (1) to induce PCD/apoptosis-like events in Naegleria fowleri have been evaluated, revealing that this compound induced reduction of ATP production showing a decrease of 99.98% in treated parasite cells. A SAR analysis have been supported with molecular modeling and analysis of the in silico ADME/Tox properties of the Laurencia sesquiterpenes debromolaurinterol (1), laurinterol (2) and allolaurinterol (3), which reinforce cyclolaurane metabolites as plausible molecular models to develop PAM treatments.

It is frequent to hear artisanal fishers criticizing a regulatory system that is not aligned with the reality of the territory, and that is defined by civil servants without the appropriate knowledge of the field and whose decisions respond to pressures that have nothing to do with the health of the ecosystems, the wellbeing of fishers, and the optimal supply of food.The commercialization of local fishery products in Tenerife is an excellent example. The European legislation allows the acquisition of small quantities by final consumers, but the different transpositions of the member states have resulted in regulatory frameworks with diverse implications depending on the side of the border where the fishing gear are used. In Tenerife, the applicable law and the market structure of local fishery products have generated certain shortages in the coastline, so consumers must travel to the few fishmongers remaining in distant urban areas or buy in their communities as they have traditionally done, either from professional fishers selling their products, now unlawfully, or to poachers, promoting black market in both cases. This paper analyses the regulatory framework regarding direct sales in Tenerife and its consequences., Es frecuente escuchar a pescadores artesanales criticar regulaciones que no se ajustan a la realidad del territorio, definidas por funcionarios desconocedores del terreno y cuyas decisiones responden a presiones que poco tienen que ver con la salud de los ecosistemas, el bienestar de los pescadores o el suministro óptimo de alimentos. En la comercialización de productos pesqueros locales en Tenerife tenemos un claro ejemplo. La normativa europea contempla la posibilidad de vender pequeñas cantidades a consumidores finales, pero las transposiciones de los países miembros han generado marcos regulatorios con diferentes implicaciones, dependiendo de si un pescador cala sus artes a un lado u otro de la frontera, o incluso en una región u otra del mismo país. En Tenerife, la legislación vigente y la estructura del mercado de productos pesqueros locales han generado cierto desabastecimiento en el litoral, por lo que los consumidores deben desplazarse a las pocas pescaderías que quedan en distantes núcleos urbanos, o adquirirlo en su comunidad, como tradicionalmente han hecho, a pescadores profesionales que venden ahora su producto de forma ilegal, o a pescadores furtivos, fomentando en ambos casos el mercado negro. Este trabajo analiza la normativa que enmarca la venta directa en Tenerife y sus consecuencias.

The City Region Food Systems approach has been proposed to achieve food system resilience and nutrition security while promoting the urgent ecological transition within urban and peri-urban areas, especially after the COVID-19 pandemic. However, the great diversity of the initiatives composing City Region Food Systems in Europe poses barriers to the assessment of their integrated sustainability. Hence, the present work is developed within the EU-H2020 project Food System in European Cities (FoodE), to build a consistent sustainability scoring system that allows comparative evaluation of City Region Food System Initiatives. Adopting a Life Cycle Thinking approach, it advances on existing knowledge and past projects, taking advantage of a participatory process, with stakeholders from multidisciplinary expertise. As a result, the research designs, and tests on 100 case studies a simplified and ready-to-use scoring mechanism based on a quali-quantitative appraisal survey tool, delivering a final sustainability score on a 1–5 points scale, to get insights on the social, economic, and environmental impacts. As in line with the needs of the UN Sustainable Development Goals, the outcome represents a step forward for the sustainable development and social innovation of food communities in cities and regions, providing a practical and empirical lens for improved planning and governance.

Naegleria fowleri is the causative agent of a central nervous system affecting disease called primary amoebic meningoencephalitis. It is a fulminant disease with a rapid progression that affects mainly children and young adults who report previous water exposure. Current treatment options are not totally effective and involve several side effects. In this work, six meroterpenoids isolated from the brown algae Gongolaria abies-marina were evaluated against N. fowleri. Gongolarone B (1), 6Z-1′-methoxyamentadione (2), and 1′-methoxyamentadione (3) were the most active molecules against N. fowleri with IC50 values between 13.27 ± 0.96 µM and 21.92 ± 1.60 µM. However, cystomexicone B (6) was the molecule with the highest selectivity index (>8.5). Moreover, all these compounds induced different cellular events compatible with the apoptosis-like PCD process, such as chromatin condensation, damages at the mitochondrial level, cell membrane disruption, and production of reactive oxygen species (ROS). Therefore, G. abies-marina could be considered as a promising source of active molecules to treat the N. fowleri infections.

Among neglected tropical diseases, leishmaniasis is one of the leading causes, not only of deaths but also of disability-adjusted life years. This disease, caused by protozoan parasites of the genus Leishmania, triggers different clinical manifestations, with cutaneous, mucocutaneous, and visceral forms. As existing treatments for this parasitosis are not sufficiently effective or safe for the patient, in this work, different sesquiterpenes isolated from the red alga Laurencia johnstonii have been studied for this purpose. The different compounds were tested in vitro against the promastigote and amastigote forms of Leishmania amazonensis. Different assays were also performed, including the measurement of mitochondrial potential, determination of ROS accumulation, and chromatin condensation, among others, focused on the detection of the cell death process known in this type of organism as apoptosis-like. Five compounds were identified that displayed leishmanicidal activity: laurequinone, laurinterol, debromolaurinterol, isolaurinterol, and aplysin, showing IC50 values against promastigotes of 1.87, 34.45, 12.48, 10.09, and 54.13 µM, respectively. Laurequinone was the most potent compound tested and was shown to be more effective than the reference drug miltefosine against promastigotes. Different death mechanism studies carried out showed that laurequinone appears to induce programmed cell death or apoptosis in the parasite studied. The obtained results underline the potential of this sesquiterpene as a novel anti-kinetoplastid therapeutic agent.