20 results on '"Fernández-Sánchez R"'
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2. Scanning force microscopy three-dimensional modes applied to the study of the dielectric response of adsorbed DNA molecules
- Author
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Gómez-Navarro, C, primary, Gil, A, additional, Álvarez, M, additional, Pablo, P J De, additional, Moreno-Herrero, F, additional, Horcas, I, additional, Fernández-Sánchez, R, additional, Colchero, J, additional, Gómez-Herrero, J, additional, and Baró, A M, additional
- Published
- 2002
- Full Text
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3. Colegio internado de lzarra Vitoria – España
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Benlloch, E., Pérez González, J. M., Ruiz Duerto, A., Alamán Simón, A., and Fernández Sánchez, R.
- Abstract
This new pavilion completes the female boarding school and an attempt has been made to integrate the entire unit into the surrounding landscape. For greater economy and shorter construction time, systems have been selected for the greatest possible use of prefabricated elements as well as modular building units. Different prefabrication systems have been used for the common zones, auditoriums, bedrooms and dining room and the building has been covered with prefabricated timber trusses, compressed wood pulp boards and cement tiles. The College is equipped with heating, fire extinction appliances and ventilation in the bedrooms. Within the framework of modern technology the results fulfill the aims set up by the proprietors., Con este nuevo pabellón exento se completa el internado masculino existente, cuidando de integrar el conjunto edificado en el paisaje circundante. En beneficio de las máximas economía y rapidez de construcción, se han elegido sistemas que permitan la mayor utilización de elementos prefabricados, procurando acudir a una modulación rígida donde ha sido posible. Se emplean diferentes sistemas de prefabricación para las zonas comunes, aulas y comedor y dormitorios, cubriendo el edificio con cerchas prefabricadas de madera, tableros aglomerados y tejas de cemento. El Colegio está dotado de calefacción, protección contra incendios y ventilación forzada en dormitorios y aseos. El resultado satisface las aspiraciones expuestas por la propiedad, dentro de la tecnología moderna.
- Published
- 1975
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4. Autopista Tarragona – Valencia - España
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Fernández Sánchez, R. and Jofré, C.
- Abstract
The present article describes the construction of the stretch Puzol-Castellón of the Mediterranean Highway in which for the second time the Californian techniques of rigid pavements have been used in a Spanish highway: bases of gravel-cement and slabs of mass concrete, with oblique, sawn, unsealed joints. This system is especially appropriate for the use of sliding shutterings which means greater savings and faster execution of the roadbed., En el presente artículo se describe la construcción del tramo Puzol-Castellón de la Autopista del Mediterráneo, en el que por segunda vez se han utilizado en una autopista española las técnicas californianas de pavimentos rígidos: bases de grava-cemento y losas de hormigón en masa, con juntas oblicuas serradas y sin sellar. Este sistema está especialmente adecuado para la utilización de equipos de encofrados deslizantes, lo que se traduce en una mayor economía y rapidez en la ejecución del firme.
- Published
- 1974
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5. Instituto de productos lácteos y derivados grasos del P.J.C. Arganda – España
- Author
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Ruiz Duerto, A., Fernández Sánchez, R., Alamán Simón, Aurelio, and Ferreres, T.
- Abstract
This article describes. a) The CLUB-DINING-ROOM, made up of: premises for different uses, kitchen, air conditioning installation, semi-basement, stores, covered porch and covered tennis court, which can be reached from outside. Metal structure, ceramic forging and enclosures of silicocalcareous brick. b) The LABORATORY BUILDING for the Institute of Dairy Products and By-Products comprises: semibasements, for plant, workshop, changing rooms, stores and other services; first floor: for direction, management, hali, board room, library and laboratory; two floors of laboratories. The structure is metal in girders and pillars, forming a three-dimensional main network —vertically and horizontally— allowing thé passage of any duct. The upright projections which undergo solar action are protected by vertical and horizontal sunbreakers which give the building a most unusual appearance., Se describen en este artículo: a) El CLUB-COMEDOR, compuesto de: local para distintos usos, cocina, instalación de acondicionami¿nto de aire, semisótano, almacén, porche cubierto y campo de tenis en la cubierta, con acceso exterior. Estructura metálica, forjados cerámicos y cerramientos de ladrillo silicocalcáreo. b) El EDIFICIO DE LABORATORIOS para el Instituto de Productos Lácteos y Derivados Grasos, consta de semisótano: para instalaciones, taller, vestuarios, almacén y otros servicios; planta primera: de dirección, administración, aula, juntas, biblioteca y laboratorio; dos plantas de laboratorios. La estructura es metálica en vigas y pilares, constituyendo una red principal tridimensional —en vei-tical y en horizontal— que permite el paso de cualquier conducto. Los alzados que sufren la acción solar están protegidos por córtaseles verticales y horizontales que prestan una fisonomía singular al edificio.
- Published
- 1973
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6. Pavimentos de hormigón en vías urbanas
- Author
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Fernández Sánchez, R. and García Meseguer, A.
- Abstract
This article describes the work done in paving the street Pedro IV, en Barcelona, and the Travesía de Manresa. The project was carried out with the collaboration of the Department of Stiff Pavements, of the Instituto Eduardo Torroja. The advantages and shortcomings connected with this type of pavement are discussed., En este artículo se describen las obras de la calle de Pedro IV, en Barcelona, y la travesía de Manresa, en cuya construcción ha colaborado el Servicio de Pavimentos Rígidos del I.E.T.c.c, destacando las ventajas e inconvenientes que presenta este tipo de solución.
- Published
- 1971
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7. Mejora del comportamiento táctico ofensivo del deporte: situaciones de colaboración y progresión empleando una enseñanza comprensiva = Improvement of tactical offensive behavior in collaborative situations and progression using a comprehensive teaching sp
- Author
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Cañabate Ortiz, Dolors, Fernández-Sánchez, R., Lara Sánchez, Amador J., and Ruiz Rico, G.
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School sports ,Educació física ,Esports escolars ,Physical education and training - Abstract
The aim of this work is to determine whether teaching as imparting a fundamental methodological aspects of teaching sport comprehensive improvement is tactical offensive behavior in students from 6th grade. The work is done with 32 students in 6th primary education Espriu Vidreres School of Girona, belonging to two different groups although the activities undertaken during the process are the same. Declarative knowledge is observed by an open-ended questionnaire that presents specific tactical situations with photographs. Procedural knowledge observed by recording and viewing video and data recording table concerning various aspects tactical offensive. The instruments used are standardized table GPAI of (Oslin, 2005), for decision-making and other table-made and validated by a pilot for guidance. The results show that students with more practical skills improve declarative knowledge, while students with less practical skills improved procedural knowledge El objetivo de este trabajo es constatar si impartiendo docencia según los aspectos metodológicos fundamentales de la enseñanza comprensiva del deporte, existe una mejora del comportamiento táctico ofensivo en alumnos de 6º de educación primaria. El trabajo se realiza con 32 alumnos de 6º de educación primaria de la Escuela Salvador Espriu de Vidreres de Girona. El conocimiento declarativo se observa mediante un cuestionario de respuestas abiertas que presenta situaciones tácticas concretas con fotografías. El procedimental mediante la grabación y visionado de vídeos y una mesa de registro de datos referente a varios aspectos tácticos ofensivos. Los instrumentos utilizados son la tabla estandarizada GPAI de Oslin (2005) para la toma de decisiones y otra, de elaboración propia y validada por una prueba piloto, para la orientación. Los resultados muestran que los alumnos con más habilidades en la práctica mejoran el conocimiento declarativo y los que muestran menos habilidades lo hacen en el conocimiento procedimental
8. Aldosterone increases vascular calcification in 'in vitro' studies,La aldosterona aumenta la calcificación vascular in vitro
- Author
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Solís, A. J., González-Pacheco, F. R., Deudero, J. J. P., Fernando Neria, Calabia, O., Fernández-Sánchez, R., and Caramelo, C.
9. ¿Qué comemos hoy?
- Author
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Lupiáñez Moral, M. D., Fernández Sánchez, R., Morón Alcalde, L., Collado, C., Mena, Isabel, and Muñoz, M.
- Subjects
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FOOD habits , *CHILD nutrition , *DIET , *REGULATION of body weight , *FOOD preferences in children - Abstract
Justificación: Paciente infantil con estancia hospitalaria prolongada y hábitos alimenticios diferentes. Presenta déficit nutricional, relacionado en principio con su patología neurológica y posteriormente con la prolongación de su estancia, que le lleva a aborrecer la comida, se intenta solucionar con dieta especial. Con esta dieta se detectaron déficit nutricional, agravándose en este caso, por sus costumbres alimenticias, rechaza algunos alimentos. Se presenta en sesión clínica, surge un plan de mejora en el que familia y paciente tienen mayor protagonismo en su alimentación, aumentando conocimientos y motivación. Objetivos: Conseguir un estado nutricional adecuado en el niño. Aumentar conocimientos familiares. Implicar a los padres en cuidados alimentarios. Eliminar déficit nutricional de dietas especiales. Aumentar peso. Metodología: Estudio de caso único. Se ha valorado según el modelo Virginia Henderson elaborándose un Plan de Cuidado individualizado, dándole seguimiento y evaluando los objetivos. Sesión clínica: Plan de mejora: Consenso enfermera-familia en los menús y Enseñar necesidades nutricionales y componentes de los alimentos para que sepan adaptarlo a sus hábitos. Resultados: Mejora la ingesta Peso: Aumento del peso de 21 kg a 26,400 kg en tres semanas. Participación de familia-paciente en elaboración de menús y registro. Conclusiones: La participación familiar es posible y necesaria, tanto para conocer las preferencias alimenticias y ajustarlas a la dieta, como en registro y motivación del niño. La familia adquiere los conocimientos para seguir tomando los nutrientes necesarios en su dieta habitual al alta (energéticos, ricos en potasio…etc). Implicación multidisciplinar. [ABSTRACT FROM AUTHOR]
- Published
- 2012
10. [Application of therapy in negative pressure complex wounds in pediatrics].
- Author
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Fernández Sánchez R and Muñoz-Miguelsanz MÁ
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- Adolescent, Child, Child, Preschool, Humans, Preoperative Care, Negative-Pressure Wound Therapy, Pain Management
- Abstract
Negative pressure wound therapy (NPWT) has been widely used in the adult patient, contrary to what happens in children, with just a few long series papers. NPWT avoids long and expensive hospital admissions, reducing the hospital costs; it also decreases the family dynamics and allows for an early return to everyday activities. In this article, we present three clinical cases consisting of a toddler, a child and a teenager with complex wounds treated with NPWT in the pediatric surgery department of the Virgen de las Nieves University Hospital in Granada. The results were excellent, with a good adherence to treatment in all cases, achieving a complete closure in two cases; the third case needed a deferred surgical closure after surgical site preparation, and showed a decrease of the wound size after the NPWT. Moreover, successful pain management was achieved during the wound cleansing, which was done under an ambulatory regime. No general anesthesia was needed. From our experience, we propose the NPWT as an alternative therapy to the classic surgical approach for this type of complex lesions in children, which offers the same advantages and results than in adults., (Copyright © 2016 Elsevier España, S.L.U. All rights reserved.)
- Published
- 2016
- Full Text
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11. AG490 promotes HIF-1α accumulation by inhibiting its hydroxylation.
- Author
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Fernández-Sánchez R, Berzal S, Sánchez-Niño MD, Neria F, Gonçalves S, Calabia O, Tejedor A, Calzada MJ, Caramelo C, Deudero JJ, and Ortiz A
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- Animals, Cattle, Cells, Cultured, Endothelial Cells cytology, Endothelial Cells drug effects, Endothelial Cells metabolism, ErbB Receptors antagonists & inhibitors, ErbB Receptors metabolism, Guanylate Cyclase antagonists & inhibitors, Guanylate Cyclase metabolism, Humans, Hydroxylation drug effects, Hypoxia-Inducible Factor 1, alpha Subunit genetics, Janus Kinase 2 antagonists & inhibitors, Janus Kinase 2 metabolism, Proteasome Endopeptidase Complex metabolism, Swine, Transcription, Genetic drug effects, Vascular Endothelial Growth Factor A genetics, Vascular Endothelial Growth Factor A metabolism, Von Hippel-Lindau Tumor Suppressor Protein metabolism, Hypoxia-Inducible Factor 1, alpha Subunit metabolism, Tyrphostins pharmacology
- Abstract
AG490 is a tyrphostin originally described as a Janus Activated Kinase (JAK) 2 inhibitor. AG490 also inhibits epidermal growth factor receptor (EGFR) and guanylyl cyclases (GC). More recently, AG490 was associated with oxidative stress protection in experimental acute kidney injury models. We now show that AG490 is also a strong activator of the Hypoxia Inducible Factor (HIF)-1. Under normoxic conditions HIF-1α is degraded through hydroxylation, von Hippel Lindau protein (VHL)-mediated ubiquitin tagging and proteasomal degradation. AG490 increased HIF-1α protein, but not HIF-1α mRNA levels, dose- and time-dependently in cultured endothelial, vascular smooth muscle and kidney proximal tubular epithelial cells. AG490 increased HIF-1α protein half-life, suggesting that HIF-1α protein accumulation resulted from a decreased degradation. In this regard, AG490 prevented HIF-1α hydroxylation and increased HIF-1α protein levels in human renal carcinoma cells expressing VHL, but did not further increase HIF-1α in VHL negative cells. AG490 did not prevent the proteasomal degradation of other proteins. HIF-1α was not upregulated by dominant negative JAK2constructs, tyrphostin AG9, the EGFR inhibitors erbstatin and genistein, the GC inhibitor Ly83583 or cGMP analogues. Finally, AG490 also increased HIF-1α transcriptional activity evidenced by the increased HIF-1α-dependent VEGF expression. In conclusion, AG490 is a novel HIF-1α activator that increases HIF-1α half-life and protein levels through interference with HIF-1α hydroxylation and VHL-mediated degradation. This action may contribute to the cell and tissue protective effects of AG490.
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- 2012
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12. Late onset retinitis pigmentosa.
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Avila-Fernández A, Cortón M, López-Molina MI, Martín-Garrido E, Cantalapiedra D, Fernández-Sánchez R, Blanco-Kelly F, Riveiro-Álvarez R, Tatu SD, Trujillo-Tiebas MJ, García-Sandoval B, Ayuso C, and Cremers FP
- Subjects
- Adult, Chromosomes, Human, Pair 14 genetics, Consanguinity, Electroretinography, Female, Genetic Linkage, Genome-Wide Association Study, Humans, Lod Score, Phenotype, Retinitis Pigmentosa diagnosis, Codon, Nonsense, DNA-Binding Proteins genetics, Polymorphism, Single Nucleotide, Retinitis Pigmentosa genetics
- Published
- 2011
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13. [Conservative treatment of penetrating trauma of the gallbladder].
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Pascual I, Fernández Luengas D, Vaquero Pérez MA, Fernández Sánchez R, and Torres Jiménez J
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- Adult, Humans, Male, Gallbladder injuries, Wounds, Stab therapy
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- 2011
- Full Text
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14. Induction of hypoxia-inducible factor 1alpha gene expression by vascular endothelial growth factor.
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Deudero JJ, Caramelo C, Castellanos MC, Neria F, Fernández-Sánchez R, Calabia O, Peñate S, and González-Pacheco FR
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- Animals, Cattle, Cytoplasm metabolism, Humans, Hydrogen Peroxide pharmacology, Hypoxanthine metabolism, Models, Biological, Mutation, Reactive Oxygen Species, Superoxide Dismutase metabolism, Superoxides metabolism, Xanthine Oxidase metabolism, rac1 GTP-Binding Protein genetics, rac1 GTP-Binding Protein metabolism, Gene Expression Regulation, Hypoxia-Inducible Factor 1, alpha Subunit metabolism, Vascular Endothelial Growth Factor A metabolism
- Abstract
Transcriptional regulation of vascular endothelial growth factor (VEGF) is critically dependent on hypoxia-inducible factor 1 (HIF-1). However, not only hypoxia, but selected growth factors can induce HIF-1. High levels of both VEGF and HIF-1 coexist in certain conditions, e.g. tumors. Nonetheless, the possibility that the stimulatory relationship between HIF-1 and VEGF may be bi-directional has not been addressed up to date. The present study in endothelial cells analyzed whether HIF-1 is regulated by a product of its own transcriptionally activated genes, namely, VEGF. As a main finding, VEGF-A(165) induced the increase of HIF-1alpha mRNA and HIF-1alpha protein and nuclear translocation. Autologous endothelial cell VEGF mRNA and protein were also increased upon exposure to exogenous VEGF. The signaling implication of reactive oxygen species was examined by comparison with H(2)O(2) and hypoxanthine/xanthine oxidase and by the superoxide dismutase mimetic, MnTMPyP, the Rac1-NAD(P)H oxidase complex inhibitor, apocynin, transfection of a dominant negative Rac1 mutant, and transfection of a p67phox antisense oligonucleotide. Superoxide anion, largely dependent on Rac1-NAD(P)H oxidase complex activity, was the critical signaling element. The transductional functionality of the pathway was confirmed by means of a reporter gene flanked by a transcription site-related VEGF sequence and by quantitative PCR. In summary, the present results reveal a previously undescribed action of VEGF on the expression of its own transcription factor, HIF-1, and on VEGF itself. This effect is principally mediated by superoxide anion, therefore identifying a new, potentially relevant role of reactive oxygen species in VEGF signaling.
- Published
- 2008
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15. [Aldosterone increases in vitro vascular calcification].
- Author
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de Solís AJ, González-Pacheco FR, Deudero JJ, Neria F, Calabia O, Fernández-Sánchez R, and Caramelo C
- Subjects
- Aldosterone pharmacology, Cells, Cultured, Humans, Muscle, Smooth, Vascular cytology, Aldosterone physiology, Calcinosis etiology, Vascular Diseases etiology
- Published
- 2008
16. Mechanisms of endothelial cell protection by blockade of the JAK2 pathway.
- Author
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Neria F, Caramelo C, Peinado H, González-Pacheco FR, Deudero JJ, de Solis AJ, Fernández-Sánchez R, Peñate S, Cano A, and Castilla MA
- Subjects
- Animals, Cattle, Cell Survival drug effects, Cells, Cultured, Cytoprotection drug effects, Cytoprotection physiology, Dose-Response Relationship, Drug, Humans, Signal Transduction drug effects, Endothelial Cells cytology, Endothelial Cells metabolism, Janus Kinase 2 antagonists & inhibitors, Janus Kinase 2 metabolism, Signal Transduction physiology, Tyrphostins administration & dosage
- Abstract
Inhibition of the JAK2/STAT pathway has been implicated recently in cytoprotective mechanisms in both vascular smooth muscle cells and astrocytes. The advent of JAK2-specific inhibitors provides a practical tool for the study of this pathway in different cellular types. An interest in finding methods to improve endothelial cell (EC) resistance to injury led us to examine the effect of JAK2/STAT inhibition on EC protection. Furthermore, the signaling pathways involved in JAK2/STAT inhibition-related actions were examined. Our results reveal, for the first time, that blockade of JAK2 with the tyrosine kinase inhibitor AG490 strongly protects cultured EC against cell detachment-dependent death and serum deprivation and increases reseeding efficiency. Confirmation of the specificity of the effects of JAK2 inhibition was attained by finding protective effects on transfection with a dominant negative JAK2. Furthermore, AG490 blocked serum deprivation-induced phosphorylation of JAK2. In terms of mechanism, treatment with AG490 induces several relevant responses, both in monolayer and detached cells. These mechanisms include the following: 1) Increase and nuclear translocation of the active, dephosphorylated form of beta-catenin. In functional terms, this translocation is transcriptionally active, and its protective effect is further supported by the stimulation of EC cytoprotection by transfectionally induced excess of beta-catenin. 2) Increase of platelet endothelial cell adhesion molecule (PECAM)/CD31 levels. 3) Increase in total and phosphorylated AKT. 4) Increase in phosphorylated glycogen synthase kinase (GSK)3alpha/beta. The present findings imply potential practical applications of JAK2 inhibition on EC. These applications affect not only EC in the monolayer but also circulating detached cells and involve mechanistic interactions not previously described.
- Published
- 2007
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17. Direct effect of F12511, a systemic inhibitor of Acyl-CoA cholesterol acyltransferase on bovine aortic endothelial cells.
- Author
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Zamorano-León JJ, Fernández-Sánchez R, López Farré AJ, Lapuente-Tiana L, Alonso-Orgaz S, Sacristán D, Junquera D, Delhon A, Conesa A, Mateos-Cáceres PJ, and Macaya C
- Subjects
- Anilides, Animals, CD40 Ligand metabolism, Cattle, Cells, Cultured, Gene Expression Regulation, Enzymologic, Nitric Oxide Synthase Type II genetics, Nitric Oxide Synthase Type II metabolism, Nitric Oxide Synthase Type III metabolism, Sterol O-Acyltransferase genetics, Sterol O-Acyltransferase metabolism, Tumor Necrosis Factor-alpha pharmacology, Acetanilides pharmacology, Aorta drug effects, Aorta enzymology, Endothelial Cells drug effects, Endothelial Cells enzymology, Enzyme Inhibitors pharmacology, Sterol O-Acyltransferase antagonists & inhibitors, Sulfhydryl Compounds pharmacology
- Abstract
F12511(S)-2',3',5'-trimethyl-4'-hydroxy-alpha-dodecylthio-alpha-phenylacetanilide (F12511) is a new Acyl-CoA cholesterol acyltransferase (ACAT) inhibitor that not only reduces the plasma cholesterol levels but also has anti-atherosclerotic actions in animals models. The study's aim was to analyze if F12511 may directly modify the ability of tumor necrosis factor--alpha (TNF-alpha)-incubated bovine aortic endothelial cells (BAEC) to express endothelial nitric oxide synthase (eNOS) protein and inflammatory-related proteins such as platelet endothelial cell adhesion molecule (PECAM) and CD40 ligand (CD40L). The addition of increasing concentrations of F12511 (10 to 10 mol/L) failed to modify the level of eNOS protein expressed in control BAEC. TNF-alpha (10 ng/mL) reduced the expression of eNOS protein. In TNF-alpha--incubated BAEC, F12511 protected eNOS expression in a concentration-dependent manner. TNF-alpha stimulated the expression of both CD40L and PECAM in cultured BAEC. F12511 (10 mol/L) failed to modify the expression of CD40L and PECAM in control and TNF-alpha-incubated BAEC. Reverse transcriptase polymerase chain reaction showed a marked expression of the ACAT-2 isoform and absent of expression of the ACAT-1 isoform in BAEC. The presence of ACAT-2 isoform in BAEC was further confirmed by Western blot. F12511 failed to modify the expression of the proinflammatory associated proteins PECAM and CD40L in the endothelium but protected eNOS expression in the endothelial cells exposed to inflammatory conditions.
- Published
- 2006
- Full Text
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18. Effect of clopidogrel on the expression of inflammatory markers in rabbit ischemic coronary artery.
- Author
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Molero L, López-Farré A, Mateos-Cáceres PJ, Fernández-Sánchez R, Luisa Maestro M, Silva J, Rodríguez E, and Macaya C
- Subjects
- Animals, CD40 Ligand metabolism, Clopidogrel, Coronary Vessels metabolism, Disease Models, Animal, Male, P-Selectin metabolism, Rabbits, Thromboplastin metabolism, Ticlopidine therapeutic use, Anti-Inflammatory Agents therapeutic use, Coronary Vessels drug effects, Myocardial Ischemia drug therapy, Platelet Aggregation Inhibitors therapeutic use, Ticlopidine analogs & derivatives
- Abstract
Inflammation and platelet activation are critical phenomena in the setting of acute coronary syndromes. Platelets may contribute to increase ischemic injury by enhancing the inflammatory response of leukocytes and endothelial myocardial cells. Pharmacological inhibition of platelet activation prevents ischemic complications in patients with coronary diseases. Agents directed against the integrin glycoprotein IIb/IIIa (GP IIb/IIIa) receptor not only inhibit platelet aggregation but also have been demonstrated to limit the inflammatory response in acute coronary syndromes. The question then raised is if the inhibition of platelet activation by other mechanisms than the blockade of GP IIb/IIIa may also exert anti-inflammatory effects. The aim of the present study was to analyze if clopidogrel may exert anti-inflammatory effects during the acute phase of myocardial infarction. A ligature was placed around the left anterior descending coronary artery of New Zealand White rabbits. After 15 min of ischemia, the myocardium was reperfused and the ischemic coronary artery was isolated 24 h after the ischemia. A group of ischemic rabbits was given a single oral dose of clopidogrel (20 mg kg(-1)) just after the arterial occlusion and the animal was recovered. Sham-operated animals served as control. P-selectin expression was significantly increased in infarcted rabbits with respect to control rabbits. Clopidogrel administration reduced P-selectin expression with respect to untreated infarcted rabbits. CD40 ligand and tissue factor expression was increased in the ischemic coronary artery and reduced after clopidogrel administration. Clopidogrel also protected endothelial nitric oxide synthase protein expression in the ischemic coronary artery, a protein that has been found downregulated under inflammatory conditions. In conclusion, inhibition of platelet activation by clopidogrel exerted anti-inflammatory effects on the ischemic coronary artery.
- Published
- 2005
- Full Text
- View/download PDF
19. [Work-related stress factors and the psychological well-being of hospital nurses].
- Author
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Escribà Agüir V, Más Pons R, Cárdenas Echegaray M, Burguete Ramos D, and Fernández Sánchez R
- Subjects
- Adult, Burnout, Professional etiology, Burnout, Professional prevention & control, Cross-Sectional Studies, Factor Analysis, Statistical, Humans, Job Satisfaction, Middle Aged, Occupational Health, Risk Factors, Spain, Surveys and Questionnaires, Burnout, Professional psychology, Nursing Staff, Hospital psychology
- Abstract
Objective: To analyze the factors which cause stress at work among hospital nursing staff according to their socio-demographic and professional characteristics and their affects on psychological welfare., Methods: A cross study carried out on a randomly chosen group of 201 nursing professionals composed of nurses and nurses aides from a general public hospital in the city of Valencia. The data was gathered by means of a self-administered questionnaire. To measure the variable response, psychological welfare, The Goldberg General Health 28 item version questionnaire, GHQ-28, was used. Work stress factors were evaluated by means of a scale valid for our cultural environment, Spain,: the Nursing Stress Scale, NSS, which consists of 34 items having a range from 0 to 102. In addition, information about diverse socio-demographic and professional variables were gathered. The authors carried out a simple analysis on all the data obtained., Results: The scores registered on the work stress factors scale were lower for nursing professionals older than 55 and for those who have more than 20 years experience in their service, with a medium of 23.28 (IC 95% = 9.87-54.84) and 25.29 (IC 95% = 11.80-54.22) respectively. On the other hand, the medium was higher for nurses with a medium of 34.16 (IC: 15.29-76.29) in comparison to the score for nurses aides. The total score on the work stress factors scale was higher in the "probable situations" of psychological stress with a medium of 42.40 (IC 95% = 21.35-84.21)., Conclusions: The results of this study demonstrate that a higher level exposure to work stress factors lowers the psychological welfare among nursing staff.
- Published
- 2000
20. [Giant lipoma of the cecum as a cause of invagination].
- Author
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Fernández Sánchez R, Vázquez Echarri J, Giménez Alvira L, and Rábago L
- Subjects
- Aged, Cecal Diseases surgery, Cecal Neoplasms surgery, Female, Humans, Intussusception surgery, Lipoma surgery, Cecal Diseases etiology, Cecal Neoplasms complications, Intussusception etiology, Lipoma complications
- Published
- 1990
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