Search

Your search keyword '"Fernández-Fabrellas, Estrella"' showing total 188 results
Start Over Author "Fernández-Fabrellas, Estrella"
188 results on '"Fernández-Fabrellas, Estrella"'

1. Influencia de las guías de práctica clínica en el diagnóstico y tratamiento de la fibrosis pulmonar idiopática. Datos del Registro de la Sociedad Española de Neumología y Cirugía Torácica

Author

Aburto, Myriam, Rodríguez-Portal, José Antonio, Fernandez-Fabrellas, Estrella, García Sevila, Raquel, Herrera Lara, Susana, Bollo de Miguel, Elena, González Ruiz, José María, Molina-Molina, María, Safont Muñoz, Belén, Godoy Mayoral, Raul, Romero Ortiz, Ana Dolores, Soler Sempere, María José, Castillo Villegas, Diego, Gaudó Navarro, Javier, Tomás López, Laura, Nuñez Sanchez, Belén, Palacios Hidalgo, Zulema, Sellares Torres, Jacobo, Sacristán Bou, Lirios, Nieto Barbero, María Asunción, Casanova Espinosa, Alvaro, Portillo-Carroz, Karina, Cano-Jimenez, Esteban, Acosta Fernández, Orlando, Legarreta, María José, and Valenzuela, Claudia

Published
2024
Full Text
View/download PDF

2. Diagnostic and Prognostic Value of Angiogenic Status in Hereditary Hemorrhagic Telangiectasia.

Author

Jaimes-Díaz, Sherlyne, Juan-Samper, Gustavo, Torres-Martínez, Susana, Escorihuela-Alares, Eva, Calabuig-Fariñas, Silvia, Rodríguez-López, Raquel, Prieto-Colodrero, Nieves, Ramon-Capilla, Mercedes, and Fernández-Fabrellas, Estrella

Subjects
HEREDITARY hemorrhagic telangiectasia, VASCULAR endothelial growth factors, PROGNOSIS, RECEIVER operating characteristic curves, BIOMARKERS
Abstract

Background/Objectives: Angiogenesis is involved in the pathogenesis of hereditary hemorrhagic telangiectasia (HHT). VEGF, ANG2, TGFβ1, and ENG are the most studied angiogenic factors, but their clinical significance in blood samples is still not completely defined. The genetic study of HHT mutations is the test of choice for diagnosing the disease, but this route is expensive, and the causative mutation is not found in up to 10% of cases. Therefore, the use of angiogenic biomarkers could facilitate a cheaper and easier approach to the diagnosis of HHT. To determine the diagnostic and prognostic value of the VEGFA, TGFβ1, ANG2, and ENG plasmatic concentrations in patients with HHT. Methods: All the participants were clinically evaluated and the concentrations of these angiogenic factors were measured using MILLIPLEX®MAP immunoassays in plasma samples collected from 44 patients with HHT and 19 controls. To evaluate the diagnostic validity of these parameters, we estimated the maximum Youden index of the ROC curve and evaluated their diagnostic value using multiple logistic regression. Results: Patients with HHT had increased blood levels of TGFβ1 and decreased ENG compared to the control group. We could not identify any angiogenic markers related to the clinical severity or epistaxis. TGFβ1 and ENG exhibited a higher discriminant capacity for HHT, especially patients with HHT1, and it was possible to develop signatures of these factors with diagnostic value. Conclusions: We identified several angiogenic factors that may be important diagnostic biomarkers for HHT and propose that the combination of TGFβ1 and ENG could represent a signature with diagnostic value for this disease. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

3. Lung Function, Radiological Findings and Biomarkers of Fibrogenesis in a Cohort of COVID-19 Patients Six Months After Hospital Discharge

Author

Safont, Belen, Tarraso, Julia, Rodriguez-Borja, Enrique, Fernández-Fabrellas, Estrella, Sancho-Chust, Jose N., Molina, Virginia, Lopez-Ramirez, Cecilia, Lope-Martinez, Amaia, Cabanes, Luis, Andreu, Ada Luz, Herrera, Susana, Lahosa, Carolina, Ros, Jose Antonio, Rodriguez-Hermosa, Juan Luis, Soriano, Joan B., Moret-Tatay, Ines, Carbonell-Asins, Juan Antonio, Mulet, Alba, and Signes-Costa, Jaime

Published
2022
Full Text
View/download PDF

4. Different Faces of Idiopathic Pulmonary Fibrosis With Preserved Forced Vital Capacity

Author

Bermudo, Guadalupe, Suarez-Cuartin, Guillermo, Rivera-Ortega, Pilar, Rodriguez-Portal, Jose Antonio, Sauleda, Jaume, Nuñez, Belen, Castillo, Diego, Aburto, Myriam, Portillo, Karina, Balcells, Eva, Badenes-Bonet, Diana, Valenzuela, Claudia, Fernandez-Fabrellas, Estrella, González-Budiño, Teresa, Cano, Esteban, Acosta, Orlando, Leiro-Fernández, Virginia, Romero, Ana, Planas-Cerezales, Lurdes, Villar, Ana, Moreno, Amalia, Laporta, Rosalia, Vicens-Zygmunt, Vanesa, Shull, Jessica, Franquet, Tomàs, Luburich, Patricio, and Molina-Molina, Maria

Published
2022
Full Text
View/download PDF

6. Aerosolterapia

Author

Chiner Vives, Eusebi, Fernández Fabrellas, Estrella, Agüero Balbín, Ramón, and Martínez García, Miguel Ángel

Published
2020
Full Text
View/download PDF

11. Cytotoxic Natural Killer Subpopulations as a Prognostic Factor of Malignant Pleural Effusion

Author

Herrera Lara, Susana, Fernández-Fabrellas, Estrella, Juan Samper, Gustavo, Marco Buades, Josefa, Andreu Lapiedra, Rafael, Pinilla Moreno, Amparo, and Morales Suárez-Varela, María

Subjects
Diagnosis, Care and treatment, Physiological aspects, Research, Prognosis, Killer cells -- Physiological aspects -- Research, Pleural effusion -- Diagnosis -- Care and treatment -- Prognosis -- Research
Abstract

Author(s): Susana Herrera Lara [sup.1] , Estrella Fernández-Fabrellas [sup.2] , Gustavo Juan Samper [sup.2] , Josefa Marco Buades [sup.3] , Rafael Andreu Lapiedra [sup.4] , Amparo Pinilla Moreno [sup.3] , [...], Background Malignant pleural effusion (MPE) is a sign of advanced disease of poor prognosis. As natural killer (NK) cells are involved in the first line of tumour defence, we aimed to validate a new diagnostic and prognostic indicator for MPE based on NK subpopulations of pleural fluid (PF) and peripheral blood (PB). Methods NK subpopulations were determined in PF and PB in 71 patients with malignant, paramalignant or benign pleural effusion. The receiver operating characteristic (ROC) curves, Kaplan-Meier, multivariable Cox model and decision trees created with the CHAID (Chi-square automatic interaction detector) methodology were employed. Results We demonstrated that the PF/PB ratios of the CD56 bright CD16- and CD56 dim CD16- NK subpopulations were higher (p = 0.013 and p = 0.003, respectively) in MPEs and paramalignant pleural effusions (PPEs) than in benign ones, with an AUC of 0.757 and 0.741, respectively. The PF/PB ratio of CD16+ NK and CD57+ NK obtained a higher hazard ratio (HR) in the crude Cox's regression analysis. In the adjusted Cox's regression analysis, the PF/PB ratio of CD16+ NK gave the highest HR (HR 6.1 [1.76-21.1]) (p = 0.004). In the decision tree created for the MPE prognosis, we observed that the main predictor variable among the studied clinical, radiological, and analytical variables was lung mass, and that 92.9% of the patients who survived had a PF/PB ratio of the CD56 dim CD16+ NK subpopulation [less than or equal to] 0.43. Conclusions Our data suggest that both the PF/PB ratios of cytotoxic subpopulations CD57+ NK and CD16+ NK are useful as a prognostic factor of MPE. Other subpopulations (CD56 bright CD16- and CD56 dim CD16- NK) could help to diagnose MPE.

Published
2019
Full Text
View/download PDF

16. Predicting Malignant and Paramalignant Pleural Effusions by Combining Clinical, Radiological and Pleural Fluid Analytical Parameters

Author

Herrera Lara, Susana, Fernández-Fabrellas, Estrella, Juan Samper, Gustavo, Marco Buades, Josefa, Andreu Lapiedra, Rafael, Pinilla Moreno, Amparo, and Morales Suárez-Varela, María

Subjects
Diagnosis, Research, Pleural effusion -- Diagnosis -- Research
Abstract

Author(s): Susana Herrera Lara [sup.1] , Estrella Fernández-Fabrellas [sup.2] , Gustavo Juan Samper [sup.2] , Josefa Marco Buades [sup.3] , Rafael Andreu Lapiedra [sup.4] , Amparo Pinilla Moreno [sup.3] , [...], Background The usefulness of clinical, radiological and pleural fluid analytical parameters for diagnosing malignant and paramalignant pleural effusion is not clearly stated. Hence this study aimed to identify possible predictor variables of diagnosing malignancy in pleural effusion of unknown aetiology. Methods Clinical, radiological and pleural fluid analytical parameters were obtained from consecutive patients who had suffered pleural effusion of unknown aetiology. They were classified into three groups according to their final diagnosis: malignant, paramalignant and benign pleural effusion. The CHAID (Chi-square automatic interaction detector) methodology was used to estimate the implication of the clinical, radiological and analytical variables in daily practice through decision trees. Results Of 71 patients, malignant (n = 31), paramalignant (n = 15) and benign (n = 25), smoking habit, dyspnoea, weight loss, radiological characteristics (mass, node, adenopathies and pleural thickening) and pleural fluid analytical parameters (pH and glucose) distinguished malignant and paramalignant pleural effusions (all with a p < 0.05). Decision tree 1 classified 77.8% of malignant and paramalignant pleural effusions in step 2. Decision tree 2 classified 83.3% of malignant pleural effusions in step 2, 73.3% of paramalignant pleural effusions and 91.7% of benign ones. Conclusions The data herein suggest that the identified predictor values applied to tree diagrams, which required no extraordinary measures, have a higher rate of correct identification of malignant, paramalignant and benign effusions when compared to techniques available today and proved most useful for usual clinical practice. Future studies are still needed to further improve the classification of patients.

Published
2017
Full Text
View/download PDF

30. Pathophysiological parameters of microcirculation as determinants of mortality in SARS-CoV-2 pneumonia

Author

Sanz Herrero, Francisco, primary, Puchades Gimeno, Francesc, additional, Verdejo Mengual, Esther, additional, Abril López De Medrano, Vicente, additional, Carrascosa García, Sara, additional, Mateo González, José Ignacio, additional, Lluch Bisbal, Amparo, additional, Carrión Collado, Noelia, additional, González Cruz, Alfonso, additional, García Deltoro, Miguel, additional, and Fernández Fabrellas, Estrella, additional

Published
2021
Full Text
View/download PDF

36. Estudio del Síndrome de apnea-hipopnea del sueño y la resistencia a la insulina

Author

Santabasilisa i Dalmau, Anna, Sampol Rubio, Gabriel, Blanquer Olivas, Rafael, Fernández Fabrellas, Estrella, Universitat Autònoma de Barcelona. Departament de Medicina, and Universitat Autònoma de Barcelona. Facultat de Medicina

Subjects
Insulina, Apnea del son, Síndrome de l'
Abstract

El nostre objectiu fou analitzar la prevalença de la resistència a la insulina (RI) en una cohort de pacients amb síndrome d'apnea-hipopnea de la son (SAHS) sota la hipòtesi que el SAHS és un factor de risc independent per al desenvolupament de RI. Realitzarem un estudi prospectiu transversal incloent-hi pacients consecutius diagnosticats de SAHS. Estudiarem les diferències entre pacients SAHS amb i sense RI. Incloem 103 pacients (73,8% homes). El 46,7% (n=42) tenien RI, i aquest grup va tenir major IMC i paràmetres més greus d'hipòxia intermitent nocturna. Els factors de risc independents per a la RI van ser l'IMC i l'ODI Nuestro objetivo fue analizar la prevalencia de la resistencia a la insulina (RI) en una cohorte de pacientes con síndrome de apnea-hipopnea del sueño (SAHS) bajo la hipótesis de que el SAHS es un factor de riesgo independiente para el desarrollo de RI. Realizamos un estudio prospectivo transversal incluyendo pacientes consecutivos diagnosticados de SAHS. Estudiamos las diferencias entre pacientes SAHS con y sin RI. Incluímos 103 pacientes (73,8% hombres). El 46,7% (n=42) tenían RI, y éste grupo tuvo mayor IMC y parámetros de mayor gravedad de hipoxia intermitente nocturna. Los factores de riesgo independientes para la RI fueron el IMC y el ODI.

Published
2021

39. Influence of the infecting serotype on the development of complications in bacteriemic pneumococcal pneumonia with high inflammatory response

Author

Sanz Herrero, Francisco, primary, Ruiz Iturriaga, Luis Alberto, additional, García Clemente, Marta María, additional, España Yandiola, Pedro Pablo, additional, Guna Serrano, Remedios, additional, Serrano Fernández, Leyre, additional, Herrero Huertas, Julia, additional, Artaraz Ereño, Amaia, additional, Carrión Collado, Noelia, additional, and Fernández Fabrellas, Estrella, additional

Published
2020
Full Text
View/download PDF

40. Angiogenesis in idiopathic pulmonary fibrosis

Author

Juan Samper, Gustavo, primary, Sabater Abad, Cristina, additional, Torres Martinez, Susana, additional, Fernández-Fabrellas, Estrella, additional, Jaimes Diaz, Vanessa, additional, Verdejo Mengual, Esther, additional, and Calabuig Fariñas, Silvia, additional

Published
2020
Full Text
View/download PDF

41. Survival of the idiopathic pulmonary fibrosis (IPF) in spain. National separ registry

Author

Jaimes Diaz, Sherlyne Vanessa, primary, Rodríguez Portal, José Antonio, additional, Fernández Fabrellas, Estrella, additional, Aburto Barrenetxea, Myriam, additional, Valenzuela Valenzuela, Claudia, additional, Planas Cerezales, Lurdes, additional, García Sevila, Raquel, additional, Bollo De Miguel, Elena, additional, Herrera Lara, Susana, additional, González Ruiz, José María, additional, and Sánchez Simón, Rafaela, additional

Published
2019
Full Text
View/download PDF

43. Demographic and clinical profile of idiopathic pulmonary fibrosis patients in Spain: the SEPAR National Registry

Author

Roche, Fernández-Fabrellas, Estrella, Molina-Molina, María, Soriano, Joan B., Rodríguez-Portal, José A., Ancochea, Julio, Valenzuela, Laura, Xaubet, Antoni, Roche, Fernández-Fabrellas, Estrella, Molina-Molina, María, Soriano, Joan B., Rodríguez-Portal, José A., Ancochea, Julio, Valenzuela, Laura, and Xaubet, Antoni

Abstract

[Background] Little is known on the characteristics of patients diagnosed with idiopathic pulmonary fibrosis (IPF) in Spain. We aimed to characterize the demographic and clinical profile of IPF patients included in the IPF National Registry of the Spanish Respiratory Society (SEPAR)., [Methods] This is a prospective, observational, multicentre and nationwide study that involved 608 IPF patients included in the SEPAR IPF Registry up to June 27th, 2017, and who received any treatment for their disease. IPF patients were predominantly males, ex-smokers, and aged in their 70s, similar to other registries., [Results] Upon inclusion, mean ± SD predicted forced vital capacity was 77.6% ± 19.4, diffusing capacity for carbon monoxide was 48.5% ± 17.7, and the 6-min walk distance was 423.5 m ± 110.4. The diagnosis was mainly established on results from the high-resolution computed tomography in the proper clinical context (55.0% of patients), while 21.2% of patients required invasive procedures (surgical lung biopsy) for definitive diagnosis. Anti-fibrotic treatment was prescribed in 69.4% of cases, 51.5% pirfenidone and 17.9% nintedanib, overall with a good safety profile., [Conclusions] The SEPAR IPF Registry should help to further characterize current characteristics and future trends of IPF patients in Spain and compare/pool them with other registries and cohorts.

Published
2019

Catalog

Books, media, physical & digital resources
See catalog results