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2. Clinical risk factors of adverse outcomes among women with COVID-19 in the pregnancy and postpartum period: a sequential, prospective meta-analysis

Author

Smith, Emily R., Oakley, Erin, Grandner, Gargi Wable, Rukundo, Gordon, Farooq, Fouzia, Ferguson, Kacey, Baumann, Sasha, Adams Waldorf, Kristina Maria, Afshar, Yalda, Ahlberg, Mia, Ahmadzia, Homa, Akelo, Victor, Aldrovandi, Grace, Bevilacqua, Elisa, Bracero, Nabal, Brandt, Justin S., Broutet, Natalie, Carrillo, Jorge, Conry, Jeanne, Cosmi, Erich, Crispi, Fatima, Crovetto, Francesca, del Mar Gil, Maria, Delgado-López, Camille, Divakar, Hema, Driscoll, Amanda J., Favre, Guillaume, Fernandez Buhigas, Irene, Flaherman, Valerie, Gale, Christopher, Godwin, Christine L., Gottlieb, Sami, Gratacós, Eduard, He, Siran, Hernandez, Olivia, Jones, Stephanie, Joshi, Sheetal, Kalafat, Erkan, Khagayi, Sammy, Knight, Marian, Kotloff, Karen L., Lanzone, Antonio, Laurita Longo, Valentina, Le Doare, Kirsty, Lees, Christoph, Litman, Ethan, Lokken, Erica M., Madhi, Shabir A., Magee, Laura A., Martinez-Portilla, Raigam Jafet, Metz, Torri D., Miller, Emily S., Money, Deborah, Moungmaithong, Sakita, Mullins, Edward, Nachega, Jean B., Nunes, Marta C., Onyango, Dickens, Panchaud, Alice, Poon, Liona C., Raiten, Daniel, Regan, Lesley, Sahota, Daljit, Sakowicz, Allie, Sanin-Blair, Jose, Stephansson, Olof, Temmerman, Marleen, Thorson, Anna, Thwin, Soe Soe, Tippett Barr, Beth A., Tolosa, Jorge E., Tug, Niyazi, Valencia-Prado, Miguel, Visentin, Silvia, von Dadelszen, Peter, Whitehead, Clare, Wood, Mollie, Yang, Huixia, Zavala, Rebecca, and Tielsch, James M.

Published
2023
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3. Continuous Risk Assessment of Late and Term Preeclampsia Throughout Pregnancy: A Retrospective Cohort Study.

Author

Rolle, Valeria, Chaveeva, Petya, Diaz-Navarro, Ander, Fernández-Buhigas, Irene, Cuenca-Gómez, Diana, Tilkova, Tanya, Santacruz, Belén, Pérez, Teresa, and Gil, Maria M.

Subjects
PREGNANCY complications, PREGNANT women, PREECLAMPSIA, PREGNANCY, LONGITUDINAL method, TEENAGE pregnancy
Abstract

Simple Summary: Preeclampsia is a serious pregnancy complication affecting between 2 to 5% of pregnancies, significantly increasing health risks for both mother and baby. Traditionally, biomarkers measured in the first trimester are used to predict the risk of preeclampsia, performing well in detecting preeclampsia happening early in pregnancy, but only identify around 40–50% of cases that develop later. This study evaluates whether incorporating repeated biomarker measurements throughout pregnancy improves the detection of preeclampsia. Using data from almost 5000 pregnancies, we developed a model that integrates these routinely measured biomarkers taking all the measures into account at the same time. The addition of repeated measures improved prediction accuracy from 50% at the start of pregnancy to approximately 84% by the end. This allows for a better, more personalized approach to monitoring each pregnancy. Background and Objectives: To evaluate the diagnostic accuracy of widely available biomarkers longitudinally measured throughout pregnancy to predict all and term (delivery at ≥37 weeks) preeclampsia (PE). Materials and Methods: This is a longitudinal retrospective study performed at Hospital Universitario de Torrejón (Madrid, Spain) and Shterev Hospital (Sofia, Bulgaria) between August 2017 and December 2022. All pregnant women with singleton pregnancies and non-malformed live fetuses attending their routine ultrasound examination and first-trimester screening for preterm PE at 11 + 0 to 13 + 6 weeks' gestation at the participating centers were invited to participate in a larger study for the prediction of pregnancy complications. The dataset was divided into two subsets to develop and validate a joint model of time-to-event outcome and longitudinal data, and to evaluate how the area under the receiving operating characteristic curve (AUROC) evolved with time. Results: 4056 pregnancies were included in the training set (59 all PE, 40 term PE) and 944 in the validation set (23 all PE, 20 term PE). For the joint model and all PE, the AUROC was 0.84 (95% CI 0.73 to 0.94) and the detection rate (DR) for a 10% screening positive rate (SPR) was 56.5 (95% CI 34.5 to 76.8). For term PE, AUROC was 0.80 (95% CI 0.69 to 0.91), and DR for a 10% SPR was 55.0 (95% CI 31.5 to 76.9). The AUROC using only information from the first trimester was 0.50 (95% CI 0.37 to 0.64) and it increased to 0.84 (0.73 to 0.94) when using all information available. Conclusions: Routinely measuring MAP and UtA-PI throughout pregnancy may improve the predictive prediction power for all and term-PE. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Association between Perinatal Outcomes and Maternal Risk Factors: A Cohort Study.

Author

Martin-Alonso, Raquel, Prieto, Paula, Fernández-Buhigas, Irene, German-Fernandez, Cristina, Aramburu, Cristina, Piqueras, Victor, Cuenca-Gomez, Diana, Ferrer, Emilia, Rolle, Valeria, Santacruz, Belén, and Gil, María M.

Subjects
GESTATIONAL diabetes, PREGNANCY complications, MATERNAL age, COHORT analysis, PREMATURE labor, MOLAR pregnancy
Abstract

Background and Objectives: The aim of this study was to analyze the association between maternal risk factors, such as age, body mass index (BMI), and cigarette smoking, and perinatal outcomes. Materials and Methods: We conducted a retrospective analysis based on prospectively collected data at Hospital Universitario de Torrejón (Madrid, Spain) between September 2017 and December 2019. All pregnant women with singleton pregnancies and non-malformed live fetuses attending their routine ultrasound examination at 11+0 to 13+6 weeks' gestation were invited to participate. The association between preeclampsia, preterm birth, gestational diabetes mellitus (GDM), small-for-gestational-age (SGA) or fetal-growth-restricted (FGR) neonates, and type of delivery and maternal age, BMI, and cigarette smoking was studied. Logistic mixed models were used to analyze the data. Results: A total of 1921 patients were included in the analysis. Women who were ≥40 years old had a significantly higher risk of having GDM (odds ratio (OR) 1.61, 95% confidence interval (CI) 1.08 to 2.36) and SGA neonates (OR 1.54, 95% CI 1.00 to 2.37). Women with a BMI < 18 had an increased rate of giving birth to SGA and FGR neonates (OR 3.28, 95% CI 1.51 to 7.05, and OR 3.73, 95% CI 1.54 to 8.37, respectively), whereas women with a BMI ≥ 35 had a higher risk of GDM (OR 3.10, 95% CI 1.95 to 4.89). Smoking increased the risk of having SGA and FGR neonates (OR 1.83, 95% CI 1.36 to 2.46, and OR 1.91, 95% CI 1.29 to 2.78). Conclusions: Advanced maternal age, low or high BMI, and smoking status are significant risk factors for pregnancy complications. Both clinicians and society should concentrate their efforts on addressing these factors to enhance reproductive health. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Efficiency of the Cerebroplacental Ratio in Identifying High-Risk Late-Term Pregnancies

Author

Martin-Alonso, Raquel, primary, Rolle, Valeria, additional, Akolekar, Ranjit, additional, de Paco Matallana, Catalina, additional, Fernández-Buhigas, Irene, additional, Sánchez-Camps, Maria Isabel, additional, Giacchino, Tara, additional, Rodríguez-Fernández, Miguel, additional, Blanco-Carnero, Jose Eliseo, additional, Santacruz, Belén, additional, and Gil, María M., additional

Published
2023
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8. PRECORSE study: Seroprevalence of severe acute respiratory syndrome coronavirus 2 in the first trimester of pregnancy during the first wave of the COVID‐19 pandemic and subsequent pregnancy complications—A cohort study

Author

Aquise, Adriana, primary, Rayo, Nieves, additional, Fernández‐Buhigas, Irene, additional, Alfonso, Ana, additional, Pagola, Natalia, additional, Rodriguez, Miguel, additional, de Miguel, Laura, additional, Santacruz, Irene, additional, Valor, Santiago, additional, Poon, Liona C., additional, Gil, María M., additional, and Santacruz, Belén, additional

Published
2023
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9. Adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection: an individual participant data meta-analysis.

Author

Smith, Emily R, Smith, Emily R, Oakley, Erin, Grandner, Gargi Wable, Ferguson, Kacey, Farooq, Fouzia, Afshar, Yalda, Ahlberg, Mia, Ahmadzia, Homa, Akelo, Victor, Aldrovandi, Grace, Tippett Barr, Beth A, Bevilacqua, Elisa, Brandt, Justin S, Broutet, Nathalie, Fernández Buhigas, Irene, Carrillo, Jorge, Clifton, Rebecca, Conry, Jeanne, Cosmi, Erich, Crispi, Fatima, Crovetto, Francesca, Delgado-López, Camille, Divakar, Hema, Driscoll, Amanda J, Favre, Guillaume, Flaherman, Valerie J, Gale, Chris, Gil, Maria M, Gottlieb, Sami L, Gratacós, Eduard, Hernandez, Olivia, Jones, Stephanie, Kalafat, Erkan, Khagayi, Sammy, Knight, Marian, Kotloff, Karen, Lanzone, Antonio, Le Doare, Kirsty, Lees, Christoph, Litman, Ethan, Lokken, Erica M, Laurita Longo, Valentina, Madhi, Shabir A, Magee, Laura A, Martinez-Portilla, Raigam Jafet, McClure, Elizabeth M, Metz, Tori D, Miller, Emily S, Money, Deborah, Moungmaithong, Sakita, Mullins, Edward, Nachega, Jean B, Nunes, Marta C, Onyango, Dickens, Panchaud, Alice, Poon, Liona C, Raiten, Daniel, Regan, Lesley, Rukundo, Gordon, Sahota, Daljit, Sakowicz, Allie, Sanin-Blair, Jose, Söderling, Jonas, Stephansson, Olof, Temmerman, Marleen, Thorson, Anna, Tolosa, Jorge E, Townson, Julia, Valencia-Prado, Miguel, Visentin, Silvia, von Dadelszen, Peter, Adams Waldorf, Kristina, Whitehead, Clare, Yassa, Murat, Tielsch, Jim M, Perinatal COVID PMA Study Collaborators, Smith, Emily R, Smith, Emily R, Oakley, Erin, Grandner, Gargi Wable, Ferguson, Kacey, Farooq, Fouzia, Afshar, Yalda, Ahlberg, Mia, Ahmadzia, Homa, Akelo, Victor, Aldrovandi, Grace, Tippett Barr, Beth A, Bevilacqua, Elisa, Brandt, Justin S, Broutet, Nathalie, Fernández Buhigas, Irene, Carrillo, Jorge, Clifton, Rebecca, Conry, Jeanne, Cosmi, Erich, Crispi, Fatima, Crovetto, Francesca, Delgado-López, Camille, Divakar, Hema, Driscoll, Amanda J, Favre, Guillaume, Flaherman, Valerie J, Gale, Chris, Gil, Maria M, Gottlieb, Sami L, Gratacós, Eduard, Hernandez, Olivia, Jones, Stephanie, Kalafat, Erkan, Khagayi, Sammy, Knight, Marian, Kotloff, Karen, Lanzone, Antonio, Le Doare, Kirsty, Lees, Christoph, Litman, Ethan, Lokken, Erica M, Laurita Longo, Valentina, Madhi, Shabir A, Magee, Laura A, Martinez-Portilla, Raigam Jafet, McClure, Elizabeth M, Metz, Tori D, Miller, Emily S, Money, Deborah, Moungmaithong, Sakita, Mullins, Edward, Nachega, Jean B, Nunes, Marta C, Onyango, Dickens, Panchaud, Alice, Poon, Liona C, Raiten, Daniel, Regan, Lesley, Rukundo, Gordon, Sahota, Daljit, Sakowicz, Allie, Sanin-Blair, Jose, Söderling, Jonas, Stephansson, Olof, Temmerman, Marleen, Thorson, Anna, Tolosa, Jorge E, Townson, Julia, Valencia-Prado, Miguel, Visentin, Silvia, von Dadelszen, Peter, Adams Waldorf, Kristina, Whitehead, Clare, Yassa, Murat, Tielsch, Jim M, and Perinatal COVID PMA Study Collaborators

Abstract

IntroductionDespite a growing body of research on the risks of SARS-CoV-2 infection during pregnancy, there is continued controversy given heterogeneity in the quality and design of published studies.MethodsWe screened ongoing studies in our sequential, prospective meta-analysis. We pooled individual participant data to estimate the absolute and relative risk (RR) of adverse outcomes among pregnant women with SARS-CoV-2 infection, compared with confirmed negative pregnancies. We evaluated the risk of bias using a modified Newcastle-Ottawa Scale.ResultsWe screened 137 studies and included 12 studies in 12 countries involving 13 136 pregnant women.Pregnant women with SARS-CoV-2 infection-as compared with uninfected pregnant women-were at significantly increased risk of maternal mortality (10 studies; n=1490; RR 7.68, 95% CI 1.70 to 34.61); admission to intensive care unit (8 studies; n=6660; RR 3.81, 95% CI 2.03 to 7.17); receiving mechanical ventilation (7 studies; n=4887; RR 15.23, 95% CI 4.32 to 53.71); receiving any critical care (7 studies; n=4735; RR 5.48, 95% CI 2.57 to 11.72); and being diagnosed with pneumonia (6 studies; n=4573; RR 23.46, 95% CI 3.03 to 181.39) and thromboembolic disease (8 studies; n=5146; RR 5.50, 95% CI 1.12 to 27.12).Neonates born to women with SARS-CoV-2 infection were more likely to be admitted to a neonatal care unit after birth (7 studies; n=7637; RR 1.86, 95% CI 1.12 to 3.08); be born preterm (7 studies; n=6233; RR 1.71, 95% CI 1.28 to 2.29) or moderately preterm (7 studies; n=6071; RR 2.92, 95% CI 1.88 to 4.54); and to be born low birth weight (12 studies; n=11 930; RR 1.19, 95% CI 1.02 to 1.40). Infection was not linked to stillbirth. Studies were generally at low or moderate risk of bias.ConclusionsThis analysis indicates that SARS-CoV-2 infection at any time during pregnancy increases the risk of maternal death, severe maternal morbidities and neonatal morbidity, but not stillbirth or intrauterine growth restriction. As more dat

Published
2023

12. Adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection: an individual participant data meta-analysis

Author

Smith, Emily R, primary, Oakley, Erin, additional, Grandner, Gargi Wable, additional, Ferguson, Kacey, additional, Farooq, Fouzia, additional, Afshar, Yalda, additional, Ahlberg, Mia, additional, Ahmadzia, Homa, additional, Akelo, Victor, additional, Aldrovandi, Grace, additional, Tippett Barr, Beth A, additional, Bevilacqua, Elisa, additional, Brandt, Justin S, additional, Broutet, Nathalie, additional, Fernández Buhigas, Irene, additional, Carrillo, Jorge, additional, Clifton, Rebecca, additional, Conry, Jeanne, additional, Cosmi, Erich, additional, Crispi, Fatima, additional, Crovetto, Francesca, additional, Delgado-López, Camille, additional, Divakar, Hema, additional, Driscoll, Amanda J, additional, Favre, Guillaume, additional, Flaherman, Valerie J, additional, Gale, Chris, additional, Gil, Maria M, additional, Gottlieb, Sami L, additional, Gratacós, Eduard, additional, Hernandez, Olivia, additional, Jones, Stephanie, additional, Kalafat, Erkan, additional, Khagayi, Sammy, additional, Knight, Marian, additional, Kotloff, Karen, additional, Lanzone, Antonio, additional, Le Doare, Kirsty, additional, Lees, Christoph, additional, Litman, Ethan, additional, Lokken, Erica M, additional, Laurita Longo, Valentina, additional, Madhi, Shabir A, additional, Magee, Laura A, additional, Martinez-Portilla, Raigam Jafet, additional, McClure, Elizabeth M, additional, Metz, Tori D, additional, Miller, Emily S, additional, Money, Deborah, additional, Moungmaithong, Sakita, additional, Mullins, Edward, additional, Nachega, Jean B, additional, Nunes, Marta C, additional, Onyango, Dickens, additional, Panchaud, Alice, additional, Poon, Liona C, additional, Raiten, Daniel, additional, Regan, Lesley, additional, Rukundo, Gordon, additional, Sahota, Daljit, additional, Sakowicz, Allie, additional, Sanin-Blair, Jose, additional, Söderling, Jonas, additional, Stephansson, Olof, additional, Temmerman, Marleen, additional, Thorson, Anna, additional, Tolosa, Jorge E, additional, Townson, Julia, additional, Valencia-Prado, Miguel, additional, Visentin, Silvia, additional, von Dadelszen, Peter, additional, Adams Waldorf, Kristina, additional, Whitehead, Clare, additional, Yassa, Murat, additional, and Tielsch, Jim M, additional

Published
2023
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15. Protocol for a sequential, prospective meta-analysis to describe coronavirus disease 2019 (COVID-19) in the pregnancy and postpartum periods

Author

Smith, Emily R., primary, Oakley, Erin, additional, He, Siran, additional, Zavala, Rebecca, additional, Ferguson, Kacey, additional, Miller, Lior, additional, Grandner, Gargi Wable, additional, Abejirinde, Ibukun-Oluwa Omolade, additional, Afshar, Yalda, additional, Ahmadzia, Homa, additional, Aldrovandi, Grace, additional, Akelo, Victor, additional, Tippett Barr, Beth A., additional, Bevilacqua, Elisa, additional, Brandt, Justin S., additional, Broutet, Natalie, additional, Fernández Buhigas, Irene, additional, Carrillo, Jorge, additional, Clifton, Rebecca, additional, Conry, Jeanne, additional, Cosmi, Erich, additional, Delgado-López, Camille, additional, Divakar, Hema, additional, Driscoll, Amanda J., additional, Favre, Guillaume, additional, Flaherman, Valerie, additional, Gale, Christopher, additional, Gil, Maria M., additional, Godwin, Christine, additional, Gottlieb, Sami, additional, Hernandez Bellolio, Olivia, additional, Kara, Edna, additional, Khagayi, Sammy, additional, Kim, Caron Rahn, additional, Knight, Marian, additional, Kotloff, Karen, additional, Lanzone, Antonio, additional, Le Doare, Kirsty, additional, Lees, Christoph, additional, Litman, Ethan, additional, Lokken, Erica M., additional, Laurita Longo, Valentina, additional, Magee, Laura A., additional, Martinez-Portilla, Raigam Jafet, additional, McClure, Elizabeth, additional, Metz, Torri D., additional, Money, Deborah, additional, Mullins, Edward, additional, Nachega, Jean B., additional, Panchaud, Alice, additional, Playle, Rebecca, additional, Poon, Liona C., additional, Raiten, Daniel, additional, Regan, Lesley, additional, Rukundo, Gordon, additional, Sanin-Blair, Jose, additional, Temmerman, Marleen, additional, Thorson, Anna, additional, Thwin, Soe, additional, Tolosa, Jorge E., additional, Townson, Julia, additional, Valencia-Prado, Miguel, additional, Visentin, Silvia, additional, von Dadelszen, Peter, additional, Adams Waldorf, Kristina, additional, Whitehead, Clare, additional, Yang, Huixia, additional, Thorlund, Kristian, additional, and Tielsch, James M., additional

Published
2022
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16. Protocol for a sequential, prospective meta-analysis to describe coronavirus disease 2019 (COVID-19) in the pregnancy and postpartum periods.

Author

Smith, Emily R, Laganà, Antonio Simone1, Smith, Emily R, Oakley, Erin, He, Siran, Zavala, Rebecca, Ferguson, Kacey, Miller, Lior, Grandner, Gargi Wable, Abejirinde, Ibukun-Oluwa Omolade, Afshar, Yalda, Ahmadzia, Homa, Aldrovandi, Grace, Akelo, Victor, Tippett Barr, Beth A, Bevilacqua, Elisa, Brandt, Justin S, Broutet, Natalie, Fernández Buhigas, Irene, Carrillo, Jorge, Clifton, Rebecca, Conry, Jeanne, Cosmi, Erich, Delgado-López, Camille, Divakar, Hema, Driscoll, Amanda J, Favre, Guillaume, Flaherman, Valerie, Gale, Christopher, Gil, Maria M, Godwin, Christine, Gottlieb, Sami, Hernandez Bellolio, Olivia, Kara, Edna, Khagayi, Sammy, Kim, Caron Rahn, Knight, Marian, Kotloff, Karen, Lanzone, Antonio, Le Doare, Kirsty, Lees, Christoph, Litman, Ethan, Lokken, Erica M, Laurita Longo, Valentina, Magee, Laura A, Martinez-Portilla, Raigam Jafet, McClure, Elizabeth, Metz, Torri D, Money, Deborah, Mullins, Edward, Nachega, Jean B, Panchaud, Alice, Playle, Rebecca, Poon, Liona C, Raiten, Daniel, Regan, Lesley, Rukundo, Gordon, Sanin-Blair, Jose, Temmerman, Marleen, Thorson, Anna, Thwin, Soe, Tolosa, Jorge E, Townson, Julia, Valencia-Prado, Miguel, Visentin, Silvia, von Dadelszen, Peter, Adams Waldorf, Kristina, Whitehead, Clare, Yang, Huixia, Thorlund, Kristian, Tielsch, James M, Smith, Emily R, Laganà, Antonio Simone1, Smith, Emily R, Oakley, Erin, He, Siran, Zavala, Rebecca, Ferguson, Kacey, Miller, Lior, Grandner, Gargi Wable, Abejirinde, Ibukun-Oluwa Omolade, Afshar, Yalda, Ahmadzia, Homa, Aldrovandi, Grace, Akelo, Victor, Tippett Barr, Beth A, Bevilacqua, Elisa, Brandt, Justin S, Broutet, Natalie, Fernández Buhigas, Irene, Carrillo, Jorge, Clifton, Rebecca, Conry, Jeanne, Cosmi, Erich, Delgado-López, Camille, Divakar, Hema, Driscoll, Amanda J, Favre, Guillaume, Flaherman, Valerie, Gale, Christopher, Gil, Maria M, Godwin, Christine, Gottlieb, Sami, Hernandez Bellolio, Olivia, Kara, Edna, Khagayi, Sammy, Kim, Caron Rahn, Knight, Marian, Kotloff, Karen, Lanzone, Antonio, Le Doare, Kirsty, Lees, Christoph, Litman, Ethan, Lokken, Erica M, Laurita Longo, Valentina, Magee, Laura A, Martinez-Portilla, Raigam Jafet, McClure, Elizabeth, Metz, Torri D, Money, Deborah, Mullins, Edward, Nachega, Jean B, Panchaud, Alice, Playle, Rebecca, Poon, Liona C, Raiten, Daniel, Regan, Lesley, Rukundo, Gordon, Sanin-Blair, Jose, Temmerman, Marleen, Thorson, Anna, Thwin, Soe, Tolosa, Jorge E, Townson, Julia, Valencia-Prado, Miguel, Visentin, Silvia, von Dadelszen, Peter, Adams Waldorf, Kristina, Whitehead, Clare, Yang, Huixia, Thorlund, Kristian, and Tielsch, James M

Abstract

We urgently need answers to basic epidemiological questions regarding SARS-CoV-2 infection in pregnant and postpartum women and its effect on their newborns. While many national registries, health facilities, and research groups are collecting relevant data, we need a collaborative and methodologically rigorous approach to better combine these data and address knowledge gaps, especially those related to rare outcomes. We propose that using a sequential, prospective meta-analysis (PMA) is the best approach to generate data for policy- and practice-oriented guidelines. As the pandemic evolves, additional studies identified retrospectively by the steering committee or through living systematic reviews will be invited to participate in this PMA. Investigators can contribute to the PMA by either submitting individual patient data or running standardized code to generate aggregate data estimates. For the primary analysis, we will pool data using two-stage meta-analysis methods. The meta-analyses will be updated as additional data accrue in each contributing study and as additional studies meet study-specific time or data accrual thresholds for sharing. At the time of publication, investigators of 25 studies, including more than 76,000 pregnancies, in 41 countries had agreed to share data for this analysis. Among the included studies, 12 have a contemporaneous comparison group of pregnancies without COVID-19, and four studies include a comparison group of non-pregnant women of reproductive age with COVID-19. Protocols and updates will be maintained publicly. Results will be shared with key stakeholders, including the World Health Organization (WHO) Maternal, Newborn, Child, and Adolescent Health (MNCAH) Research Working Group. Data contributors will share results with local stakeholders. Scientific publications will be published in open-access journals on an ongoing basis.

Published
2022

17. Anti-SARS-CoV-2-specific antibodies in human breast milk following SARS-CoV-2 infection during pregnancy: a prospective cohort study

Author

Fernández-Buhigas, Irene, primary, Rayo, Nieves, additional, Silos, Julia Cuesta, additional, Serrano, Berta, additional, Ocón-Hernández, Olga, additional, Leung, Bo Wah, additional, Delgado, Juan Luis, additional, Sánchez-Nieves, David, additional, Valle, Silvia, additional, de Miguel, Laura, additional, Salgado, Aroa, additional, Tanoira, Ramón Perez, additional, Rolle, Valeria, additional, Santacruz, Belén, additional, Gil, María M, additional, and Poon, Liona C., additional

Published
2022
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18. Protocol for a sequential, prospective meta-analysis to describe coronavirus disease 2019 (COVID-19) in the pregnancy and postpartum periods

Author

Smith, Emily R., primary, Oakley, Erin, additional, He, Siran, additional, Zavala, Rebecca, additional, Ferguson, Kacey, additional, Miller, Lior, additional, Grandner, Gargi Wable, additional, Abejirinde, Ibukun-Oluwa Omolade, additional, Afshar, Yalda, additional, Ahmadzia, Homa, additional, Aldrovandi, Grace, additional, Akelo, Victor, additional, Tippett Barr, Beth A., additional, Bevilacqua, Elisa, additional, Brandt, Justin S., additional, Broutet, Natalie, additional, Fernández-Buhigas, Irene, additional, Carrillo, Jorge, additional, Clifton, Rebecca, additional, Conry, Jeanne, additional, Cosmi, Erich, additional, Delgado-López, Camille, additional, Divakar, Hema, additional, Driscoll, Amanda J., additional, Favre, Guillaume, additional, Flaherman, Valerie, additional, Gale, Christopher, additional, Gil, Maria M., additional, Godwin, Christine, additional, Gottlieb, Sami, additional, Bellolio, Olivia Hernandez, additional, Kara, Edna, additional, Khagayi, Sammy, additional, Kim, Caron Rahn, additional, Knight, Marian, additional, Kotloff, Karen, additional, Lanzone, Antonio, additional, Le Doare, Kirsty, additional, Lees, Christoph, additional, Litman, Ethan, additional, Lokken, Erica M., additional, Longo, Valentina Laurita, additional, Magee, Laura A., additional, Martinez-Portilla, Raigam Jafet, additional, McClure, Elizabeth, additional, Metz, Torri D., additional, Money, Deborah, additional, Mullins, Edward, additional, Nachega, Jean B., additional, Panchaud, Alice, additional, Playle, Rebecca, additional, Poon, Liona C., additional, Raiten, Daniel, additional, Regan, Lesley, additional, Rukundo, Gordon, additional, Sanin-Blair, Jose, additional, Temmerman, Marleen, additional, Thorson, Anna, additional, Thwin, Soe Soe, additional, Tolosa, Jorge E., additional, Townson, Julia, additional, Valencia-Prado, Miguel, additional, Visentin, Silvia, additional, von Dadelszen, Peter, additional, Waldorf, Kristina Adams, additional, Whitehead, Clare, additional, Yang, Huixia, additional, Thorlund, Kristian, additional, and Tielsch, James M., additional

Published
2020
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19. Colaboradores

Author

Acién Álvarez, Pedro, Acién Sánchez, M.ª Isabel, Alcázar Zambrano, Juan Luis, Alconchel Gago, Felipe, Alguilar Melgar, Ashanti Edith, Arroyo Lemarroy, Tayde, Barceló Valcárcel, Francisco, Luis Bartha Rasero, José, Batiza Resendiz, Víctor Alfonso, Baumgarten Kuster Uyeda, M.ª Gabriela, Bayoumi Delis, Blanca, Blanco Carnero, José Eliseo, San Cristóbal, Jorge Burgos, Caamiña Álvarez, Sara, Calaf Alsina, Joaquim, Calero Megías, Raúl, Calvo Alemán, Mercedes, Campos Hernández, Irene, Cancelo Hidalgo, M.ª Jesús, Cánovas López, Laura, Carratalá Pérez, Olga, Carrillo Badillo, M.ª Paz, Casanova Pedraz, Cristina, Cascales Campos, Pedro Antonio, Castelo Branco, Camil, César Garello, Néstor, Chacón Cruz, Enrique, Company Calabuig, Ana M.ª, Cortés León, Marta, Cortés Sandoval, Salvador, Crespo Criado, Marta, Cruz Martínez, Milagros, Cuerva González, Marcos Javier, De Dulanto García, Lucía, Katalin de Jármy Di Bella, Zsuzsanna Ilona, Fernández-Miranda, María De la Calle, de la Viuda García, Esther, Rodríguez, Carmen de Luis, De Paco Matallana, Catalina, Real, Ana del Campo, del Castillo, Andrés, Delgado Gonzálvez, Juan Luis, Delgado Marín, Juan Luis, Díaz Rosas, Gema, Domingo del Pozol, Santiago, Donaire González, M.ª Concepción, Dosouto Capel, Carlos, Escribano Tórtola, Juan José, Escrig Estrems, Julia, Espinós Gómez, Juan José, Farràs Llobet, Alba, Fernández Blanco, Lorena, Fernández Buhigas, Irene, Fernández Lara, Alfredo, Ferreira Sartori, Marair Gracio, Fidalgo Conde, Ana M.ª, Fiol Ruiz, Gabriel, Ganzo Suárez, Tania, García Campaña, Encarnación, García González, Coral, García Ruiz, Itziar, García Sánchez, Marta, García Velasco, Juan Antonio, Garrido Esteban, Rosa Ana, Giavedoni, M.ª Eugenia, Gil Mira, M.ª del Mar, Gómez Carrascosa, Inmaculada, Gómez Monreal, Benjamina, Vanegas, Otilia R. González, Guijarro Campillo, Alberto Rafael, Guillén Antón, Alfredo, Henales Almaraz, José Gerardo, Henales Ocampo, Alexis Stephano, Hernández del Rincón, Juan Pedro, Hernández Suárez, Mercedes, Herrera Giménez, Javier, Herrero Calderón, Rosa, Iniesta Albadalejo, Miguel Ángel, Jiménez Hernández, M.ª Carmen, Lago Leal, Víctor, Larrañaga Azcárate, Carlos, Leal García, M.ª Ángeles, Lessa Ortiz, Luiz Felipe, Ling García, José Pablo, Lino de Faria, Amanda, Lizárraga Cepeda, Esteban, López de la Manzanara Cano, Carlos Andrés, López Fernández, José Antonio, López Magallón, Sara, Machado Linde, Francisco, Magdaleno Dans, Fernando, Manzanares López, Julia, Marcos Puig, Beatriz, Mariconde, José M.ª, Marín Sánchez, Pilar, Martí Edo, Marina, Martín Bermejo, Natalia, Martín Gómez, María, Martínez Cendán, Juan Pedro, Martínez Escoriza, Juan Carlos, Martínez García, M.ª Sol, Martínez Jareño, Manuel, Martínez Varea, Alicia, Martínez Vicente, Laura, Mateos López, Silvia, Matorras Weinig, Roberto, Melchor Corcóstegui, Iñigo, Melchor Marcos, Juan Carlos, Méndez Sánchez, Nieves, Mendoza, Manel, Mendoza Huertas, Loreto, Ladrón de Guevara, Nicolás Mendoza, Messiaen, Eline, Michel Vergara, Jorge Alejandro, Mínguez Milio, José Ángel, García, Francisca S. Molina, Muñoz Contreras, María, Muñoz Muñiz, Mar, Navas Bermejo, Yanire, Nazario Redondo, Conny, Nieto Díaz, Aníbal, Núñez Calonge, Rocío, Núñez Cerrato, M.ª Elena, Oliva Sánchez, Raquel, Orenes Moreno, María, Orós López, Daniel, Orozco Fernández, Rodrigo, Ortiz Simón, Almudena, Ortola Vercher, Victoria, Carrillo de Albornoz, Eduardo Osuna, Padilla Lara, Felipe, Palacios Marqués, Ana M.ª, Paules Tejero, Cristina, Peces Rama, Almudena, Penadés Sanz, Inmaculada, Perales Marín, Alfredo, Pingarrón Santofimia, Carmen, Piñel Pérez, Carlos, Piñero Madrona, Antonio, Pires Núñez, Yumay, Plasencia Acevedo, Walter, Polo Ramos, Ana, Porcel Marín, M.ª Carmen, Prieto Sánchez, M.ª Teresa, Puertas Prieto, Alberto, Puga Álvarez, Marco, Puig Marzal, Isabel, Quereda Seguí, Francisco, Quintana Bert, Raquel, Remezal Solano, Manuel, Rodríguez Gómez, Leire, Rodríguez Hernández, José Ramón, Rodríguez Jiménez, Bibiana, Ros Cerro, Cristina, Rovira Negre, Ramón, Ruiz Durán, Susana, Ruiz García, Marta, Ruiz Martínez, Sara, Julián Salas Camacho, José, Sánchez Beltrán, Cristina, Sánchez Borrego, Rafael, Sánchez Ferrer, M.ª Luisa, Sánchez Hipólito, Lourdes, Sánchez Prieto, Manuel, Sánchez Romero, Javier, Sánchez-Mateos Enrique, M.ª Rosa, Santacruz Martín, Belén, Sepúlveda González, Gerardo, Serrano Sánchez, Berta, Suy Franch, Anna, Tapiador Albertos, Silvia, Toro Ortiz, Juan Carlos, Torroba Carón, M.ª Amparo, Tur Torres, M.ª Helena, Turiel Miranda, Miriam, Urbano Reyes, M.ª Isabel, Usandizaga Elío, Ramón, Valfré, Roberto, Rodríguez, Sheila A. Vázquez, Laveriano, Walter R. Ventura, Vilches Jiménez, José Carlos, and Zabaleta Loinaz, Irati

Published
2022
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21. Congenital infection of SARS-CoV-2 in live-born neonates: a population-based descriptive study

Author

Burgos, Jorge, Diago, Vicente, de la Calle, María, Muner, Marta, Ruiz, Sara, Orós, Daniel, Ocón, Olga, Molina García, Francisca Sonia, Gil, Mar, Delgado, Juan Luis, Garcia-Ruiz, Itziar, Sulleiro, Elena, Serrano, Berta, Fernandez-Buhigas, Irene, Rodriguez-Gomez, Leire, Sanchez-Nieves Fernandez, David, Anton-Pagarolas, Andrés, Esperalba-Esquerra, Juliana, Frick, Marie Antoinette, Camba, Fatima, Navarro-Jimenez, Alexandra, Fernandez-Hidalgo, Nuria, Maiz, Nerea, Carreras, Elena, and Suy, Anna

Published
2021
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22. Pregnancy Outcomes and SARS-CoV-2 Infection: The Spanish Obstetric Emergency Group Study.

Author

Cruz Melguizo, Sara, de la Cruz Conty, María Luisa, Carmona Payán, Paola, Abascal-Saiz, Alejandra, Pintando Recarte, Pilar, González Rodríguez, Laura, Cuenca Marín, Celia, Martínez Varea, Alicia, Oreja Cuesta, Ana Belén, Rodríguez, Pilar Prats, Fernández Buhigas, Irene, Rodríguez Gallego, María Victoria, Fernández Alonso, Ana María, López Pérez, Rocío, Broullón Molanes, José Román, Encinas Pardilla, María Begoña, Ramírez Gómez, Mercedes, Gimeno Gimeno, María Joaquina, Sánchez Muñoz, Antonio, and Martínez-Pérez, Oscar

Subjects
PREGNANCY outcomes, SARS-CoV-2, OBSTETRICAL emergencies, PREMATURE labor, PREGNANT women, ECLAMPSIA, PREMATURE rupture of fetal membranes
Abstract

Pregnant women who are infected with SARS-CoV-2 are at an increased risk of adverse perinatal outcomes. With this study, we aimed to better understand the relationship between maternal infection and perinatal outcomes, especially preterm births, and the underlying medical and interventionist factors. This was a prospective observational study carried out in 78 centers (Spanish Obstetric Emergency Group) with a cohort of 1347 SARS-CoV-2 PCR-positive pregnant women registered consecutively between 26 February and 5 November 2020, and a concurrent sample of PCR-negative mothers. The patients' information was collected from their medical records, and the association of SARS-CoV-2 and perinatal outcomes was evaluated by univariable and multivariate analyses. The data from 1347 SARS-CoV-2-positive pregnancies were compared with those from 1607 SARS-CoV-2-negative pregnancies. Differences were observed between both groups in premature rupture of membranes (15.5% vs. 11.1%, p < 0.001); venous thrombotic events (1.5% vs. 0.2%, p < 0.001); and severe pre-eclampsia incidence (40.6 vs. 15.6%, p = 0.001), which could have been overestimated in the infected cohort due to the shared analytical signs between this hypertensive disorder and COVID-19. In addition, more preterm deliveries were observed in infected patients (11.1% vs. 5.8%, p < 0.001) mainly due to an increase in iatrogenic preterm births. The prematurity in SARS-CoV-2-affected pregnancies results from a predisposition to end the pregnancy because of maternal disease (pneumonia and pre-eclampsia, with or without COVID-19 symptoms). [ABSTRACT FROM AUTHOR]

Published
2021
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