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1. Comparative external validation of the PRECISE-DAPT and PARIS risk scores in 4424 acute coronary syndrome patients treated with prasugrel or ticagrelor

Author

Bianco, Matteo, D'ascenzo, Fabrizio, Raposeiras Roubin, Sergio, Kinnaird, Tim, Peyracchia, Mattia, Ariza-Solé, Albert, Cerrato, Enrico, Manzano-Fernández, Sergio, Gravinese, Carol, Templin, Christian, Destefanis, Paola, Velicki, Lazar, Luciano, Alessia, Xanthopoulou, Ioanna, Rinaldi, Mauro, Rognoni, Andrea, Varbella, Ferdinando, Boccuzzi, Giacomo, Omedè, Pierluigi, Montabone, Andrea, Bernardi, Alessandro, Taha, Salma, Rossini, Roberta, Durante, Alessandro, Gili, Sebastiano, Magnani, Giulia, Autelli, Michele, Grosso, Alberto, Blanco, Pedro Flores, Giustetto, Carla, Garay, Alberto, Quadri, Giorgio, Queija, Berenice Caneiro, Srdanovic, Ilija, Paz, Rafael Cobas, Fernández, María Cespón, Pousa, Isabel Muñoz, Gallo, Diego, Morbiducci, Umberto, Dominguez-Rodriguez, Alberto, Lopez-Cuenca, Ángel, Cequier, Angel, Alexopoulos, Dimitrios, Iñiguez-Romo, Andres, Pozzi, Roberto, Assi, Emad Abu, and Valgimigli, Marco

Published
2020
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2. Average daily ischemic versus bleeding risk in patients with ACS undergoing PCI: Insights from the BleeMACS and RENAMI registries

Author

D’Ascenzo, Fabrizio, Biolè, Carloalberto, Raposeiras-Roubin, Sergio, Gaido, Federico, Abu-Assi, Emad, Kinnaird, Tim, Ariza-Solé, Albert, Liebetrau, Christoph, Manzano-Fernández, Sergio, Boccuzzi, Giacomo, Henriques, Jose Paulo Simao, Templin, Christian, Wilton, Stephen B., Omedè, Pierluigi, Velicki, Lazar, Xanthopoulou, Ioanna, Correia, Luis, Cerrato, Enrico, Rognoni, Andrea, Fabrizio, Ugo, Nuñez-Gil, Iván, Montabone, Andrea, Taha, Salma, Fujii, Toshiharu, Durante, Alessandro, Song, Xiantao, Gili, Sebastiano, Magnani, Giulia, Autelli, Michele, Bongiovanni, Federica, Grosso, Alberto, Kawaji, Tetsuma, Blanco, Pedro Flores, Garay, Alberto, Quadri, Giorgio, Alexopoulos, Dimitrios, Queija, Berenice Caneiro, Huczek, Zenon, Paz, Rafael Cobas, González-Juanatey, José Ramón, Fernández, María Cespón, Nie, Shao-Ping, Pousa, Isabel Muñoz, Kawashiri, Masa-aki, Rettegno, Sara, Gallo, Diego, Morbiducci, Umberto, Conrotto, Federico, Dominguez-Rodriguez, Alberto, Valdés, Mariano, Cequier, Angel, Iñiguez-Romo, Andrés, Biondi-Zoccai, Giuseppe, Stone, Gregg W., and De Ferrari, Gaetano Maria

Published
2020
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3. Efficacy and Safety of Clopidogrel, Prasugrel and Ticagrelor in ACS Patients Treated with PCI: A Propensity Score Analysis of the RENAMI and BleeMACS Registries

Author

Peyracchia, Mattia, Saglietto, Andrea, Biolè, Carloalberto, Raposeiras-Roubin, Sergio, Abu-Assi, Emad, Kinnaird, Tim, Ariza-Solé, Albert, Liebetrau, Christoph, Manzano-Fernández, Sergio, Boccuzzi, Giacomo, Henriques, Jose Paulo Simao, Wilton, Stephen B., Velicki, Lazar, Xanthopoulou, Ioanna, Correia, Luis, Rognoni, Andrea, Fabrizio, Ugo, Nuñez-Gil, Iván, Montabone, Andrea, Taha, Salma, Fujii, Toshiharu, Durante, Alessandro, Gili, Sebastiano, Magnani, Giulia, Autelli, Michele, Grosso, Alberto, Kawaji, Tetsuma, Blanco, Pedro Flores, Garay, Alberto, Quadri, Giorgio, Queija, Berenice Caneiro, Huczek, Zenon, Paz, Rafael Cobas, González-Juanatey, José Ramón, Fernández, María Cespón, Nie, Shao-Ping, D’Amico, Maurizio, Pousa, Isabel Muñoz, Kawashiri, Masa-aki, Gallo, Diego, Morbiducci, Umberto, Dominguez-Rodriguez, Alberto, Lopez-Cuenca, Angel, Cequier, Angel, Alexopoulos, Dimitrios, Iñiguez-Romo, Andrés, Grossomarra, Walter, Usmiani, Tullio, Rinaldi, Mauro, and D’Ascenzo, Fabrizio

Published
2020
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4. Incidence and predictors of bleeding in ACS patients treated with PCI and prasugrel or ticagrelor: An analysis from the RENAMI registry

Author

D'Ascenzo, Fabrizio, Grosso, Alberto, Abu-Assi, Emad, Kinnaird, Tim, Ariza-Solé, Albert, Manzano-Fernández, Sergio, Templin, Christian, Velicki, Lazar, Xanthopoulou, Ioanna, Cerrato, Enrico, Rognoni, Andrea, Boccuzzi, Giacomo, Omedè, Pierluigi, Montabone, Andrea, Taha, Salma, Durante, Alessandro, Gili, Sebastiano, Ali, Hosam Hasan, Magnani, Giulia, Autelli, Michele, Blanco, Pedro Flores, Garay, Alberto, Quadri, Giorgio, Marra, Walter Grosso, Varbella, Ferdinando, Queija, Berenice Caneiro, Paz, Rafael Cobas, Fernández, María Cespón, Pousa, Isabel Muñoz, Gallo, Diego, Morbiducci, Umberto, Dominguez-Rodriguez, Alberto, Valdés, Mariano, Cequier, Angel, Alexopoulos, Dimitrios, Iñiguez-Romo, Andrés, Gaita, Fiorenzo, and Raposeiras-Roubin, Sergio

Published
2018
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5. Anemia in patients with acute coronary syndromes treated with prasugrel or ticagrelor: Insights from the RENAMI registry

Author

Guerrero, Carme, Garay, Alberto, Ariza-Solé, Albert, Formiga, Francesc, Raposeiras-Roubín, Sergio, Abu-Assi, Emad, D'Ascenzo, Fabrizio, Kinnaird, Timm, Manzano-Fernández, Sergio, Alegre, Oriol, Sánchez-Salado, José C., Lorente, Victòria, Templin, Christian, Velicki, Lazar, Xanthopoulou, Ioanna, Cerrato, Enrico, Rognoni, Andrea, Boccuzzi, Giacomo, Omedè, Pierluigi, Montabone, Andrea, Taha, Salma, Durante, Alessandro, Gili, Sebastiano, Magnani, Giulia, Conrotto, Federico, Bertaina, Maurizio, Autelli, Michele, Grosso, Alberto, Blanco, Pedro Flores, Quadri, Giorgio, Varbella, Ferdinando, Tomassini, Francesco, Queija, Berenice Caneiro, Paz, Rafael Cobas, Fernández, María Cespón, Pousa, Isabel Muñoz, Gallo, Diego, Morbiducci, Umberto, Dominguez-Rodriguez, Alberto, Valdés, Mariano, Alexopoulos, Dimitrios, Iñiguez-Romo, Andrés, Gaita, Fiorenzo, and Cequier, Ángel

Published
2018
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6. Real-World Data of Prasugrel vs. Ticagrelor in Acute Myocardial Infarction: Results from the RENAMI Registry

Author

De Filippo, Ovidio, Cortese, Martina, D´Ascenzo, Fabrizio, Raposeiras-Roubin, Sergio, Abu-Assi, Emad, Kinnaird, Tim, Ariza-Solé, Albert, Manzano-Fernández, Sergio, Templin, Christian, Velicki, Lazar, Xanthopoulou, Ioanna, Cerrato, Enrico, Rognoni, Andrea, Boccuzzi, Giacomo, Montefusco, Antonio, Montabone, Andrea, Taha, Salma, Durante, Alessandro, Gili, Sebastiano, Magnani, Giulia, Autelli, Michele, Grosso, Alberto, Blanco, Pedro Flores, Garay, Alberto, Quadri, Giorgio, Varbella, Ferdinando, Queija, Berenice Caneiro, Paz, Rafael Cobas, Fernández, María Cespón, Pousa, Isabel Muñoz, Gallo, Diego, Morbiducci, Umberto, Dominguez-Rodriguez, Alberto, Valdés, Mariano, Cequier, Angel, Alexopoulos, Dimitrios, Iñiguez-Romo, Andrés, and Rinaldi, Mauro

Published
2019
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7. Hypotension at heart failure discharge: Should it be a limiting factor for drug titration?

Author

Melendo-Viu, Maria, primary, Dobarro, David, additional, López, Álvaro Marchán, additional, Domínguez, Luis Manuel, additional, Raposeiras-Roubín, Sergio, additional, Abu-Assi, Emad, additional, González, Carmen Cardero, additional, Pérez-Expósito, Lucía, additional, Fernández, María Cespón, additional, Barcia, Jose Antonio Parada, additional, Pérez, Manuel Barreiro, additional, García, Enrique, additional, and Romo, Andrés Íñiguez, additional

Published
2023
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8. Correction to: Real-World Data of Prasugrel vs. Ticagrelor in Acute Myocardial Infarction: Results from the RENAMI Registry

Author

De Fillippo, Ovidio, Cortese, Martina, D´Ascenzo, Fabrizio, Raposeiras-Roubin, Sergio, Abu-Assi, Emad, Kinnaird, Tim, Ariza-Solé, Albert, Manzano-Fernández, Sergio, Templin, Christian, Velicki, Lazar, Xanthopoulou, Ioanna, Cerrato, Enrico, Rognoni, Andrea, Boccuzzi, Giacomo, Montefusco, Antonio, Montabone, Andrea, Taha, Salma, Durante, Alessandro, Gili, Sebastiano, Magnani, Giulia, Autelli, Michele, Grosso, Alberto, Blanco, Pedro Flores, Garay, Alberto, Quadri, Giorgio, Varbella, Ferdinando, Queija, Berenice Caneiro, Paz, Rafael Cobas, Fernández, María Cespón, Pousa, Isabel Muñoz, Gallo, Diego, Morbiducci, Umberto, Dominguez-Rodriguez, Alberto, Valdés, Mariano, Cequier, Angel, Alexopoulos, Dimitrios, Iñiguez-Romo, Andrés, and Rinaldi, Mauro

Published
2019
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9. Long versus short dual antiplatelet therapy in acute coronary syndrome patients treated with prasugrel or ticagrelor and coronary revascularization: Insights from the RENAMI registry

Author

D'Ascenzo, Fabrizio, Bertaina, Maurizio, Fioravanti, Francesco, Bongiovanni, Federica, Raposeiras-Roubin, Sergio, Abu-Assi, Emad, Kinnaird, Tim, Ariza-Solé, Albert, Manzano-Fernández, Sergio, Templin, Christian, Velicki, Lazar, Xanthopoulou, Ioanna, Cerrato, Enrico, Rognoni, Andrea, Boccuzzi, Giacomo, Omedè, Pierluigi, Montabone, Andrea, Taha, Salma, Durante, Alessandro, Gili, Sebastiano, Magnani, Giulia, Autelli, Michele, Grosso, Alberto, Blanco, Pedro Flores, Garay, Alberto, Quadri, Giorgio, Varbella, Ferdinando, Queija, Berenice Caneiro, Paz, Rafael Cobas, Fernández, María Cespón, et al, University of Zurich, and D'Ascenzo, Fabrizio

Subjects
10209 Clinic for Cardiology, 610 Medicine & health, 2705 Cardiology and Cardiovascular Medicine, 2713 Epidemiology
Published
2020

10. Efficacy and Safety of Clopidogrel, Prasugrel and Ticagrelor in ACS Patients Treated with PCI: A Propensity Score Analysis of the RENAMI and BleeMACS Registries

Author

Peyracchia, Mattia, primary, Saglietto, Andrea, additional, Biolè, Carloalberto, additional, Raposeiras-Roubin, Sergio, additional, Abu-Assi, Emad, additional, Kinnaird, Tim, additional, Ariza-Solé, Albert, additional, Liebetrau, Christoph, additional, Manzano-Fernández, Sergio, additional, Boccuzzi, Giacomo, additional, Henriques, Jose Paulo Simao, additional, Wilton, Stephen B., additional, Velicki, Lazar, additional, Xanthopoulou, Ioanna, additional, Correia, Luis, additional, Rognoni, Andrea, additional, Fabrizio, Ugo, additional, Nuñez-Gil, Iván, additional, Montabone, Andrea, additional, Taha, Salma, additional, Fujii, Toshiharu, additional, Durante, Alessandro, additional, Gili, Sebastiano, additional, Magnani, Giulia, additional, Autelli, Michele, additional, Grosso, Alberto, additional, Kawaji, Tetsuma, additional, Blanco, Pedro Flores, additional, Garay, Alberto, additional, Quadri, Giorgio, additional, Queija, Berenice Caneiro, additional, Huczek, Zenon, additional, Paz, Rafael Cobas, additional, González-Juanatey, José Ramón, additional, Fernández, María Cespón, additional, Nie, Shao-Ping, additional, D’Amico, Maurizio, additional, Pousa, Isabel Muñoz, additional, Kawashiri, Masa-aki, additional, Gallo, Diego, additional, Morbiducci, Umberto, additional, Dominguez-Rodriguez, Alberto, additional, Lopez-Cuenca, Angel, additional, Cequier, Angel, additional, Alexopoulos, Dimitrios, additional, Iñiguez-Romo, Andrés, additional, Grossomarra, Walter, additional, Usmiani, Tullio, additional, Rinaldi, Mauro, additional, and D’Ascenzo, Fabrizio, additional

Published
2019
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11. Long versus short dual antiplatelet therapy in acute coronary syndrome patients treated with prasugrel or ticagrelor and coronary revascularization: Insights from the RENAMI registry

Author

D'Ascenzo, Fabrizio, primary, Bertaina, Maurizio, additional, Fioravanti, Francesco, additional, Bongiovanni, Federica, additional, Raposeiras-Roubin, Sergio, additional, Abu-Assi, Emad, additional, Kinnaird, Tim, additional, Ariza-Solé, Albert, additional, Manzano-Fernández, Sergio, additional, Templin, Christian, additional, Velicki, Lazar, additional, Xanthopoulou, Ioanna, additional, Cerrato, Enrico, additional, Rognoni, Andrea, additional, Boccuzzi, Giacomo, additional, Omedè, Pierluigi, additional, Montabone, Andrea, additional, Taha, Salma, additional, Durante, Alessandro, additional, Gili, Sebastiano, additional, Magnani, Giulia, additional, Autelli, Michele, additional, Grosso, Alberto, additional, Blanco, Pedro Flores, additional, Garay, Alberto, additional, Quadri, Giorgio, additional, Varbella, Ferdinando, additional, Queija, Berenice Caneiro, additional, Paz, Rafael Cobas, additional, Fernández, María Cespón, additional, Pousa, Isabel Muñoz, additional, Gallo, Diego, additional, Morbiducci, Umberto, additional, Dominguez-Rodriguez, Alberto, additional, Valdés, Mariano, additional, Cequier, Angel, additional, Alexopoulos, Dimitrios, additional, Iñiguez-Romo, Andrés, additional, Gaita, Fiorenzo, additional, Rinaldi, Mauro, additional, and Lüscher, Thomas F, additional

Published
2019
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12. Long versus short dual antiplatelet therapy in acute coronary syndrome patients treated with prasugrel or ticagrelor and coronary revascularization: Insights from the RENAMI registry.

Author

D'Ascenzo F, Bertaina M, Fioravanti F, Bongiovanni F, Raposeiras-Roubin S, Abu-Assi E, Kinnaird T, Ariza-Solé A, Manzano-Fernández S, Templin C, Velicki L, Xanthopoulou I, Cerrato E, Rognoni A, Boccuzzi G, Omedè P, Montabone A, Taha S, Durante A, Gili S, Magnani G, Autelli M, Grosso A, Blanco PF, Garay A, Quadri G, Varbella F, Queija BC, Paz RC, Fernández MC, Pousa IM, Gallo D, Morbiducci U, Dominguez-Rodriguez A, Valdés M, Cequier A, Alexopoulos D, Iñiguez-Romo A, Gaita F, Rinaldi M, and Lüscher TF

Subjects
Acute Coronary Syndrome diagnosis, Acute Coronary Syndrome mortality, Aged, Aspirin adverse effects, Drug Administration Schedule, Europe, Female, Hemorrhage chemically induced, Humans, Male, Non-ST Elevated Myocardial Infarction diagnosis, Non-ST Elevated Myocardial Infarction mortality, Platelet Aggregation Inhibitors adverse effects, Prasugrel Hydrochloride adverse effects, Recurrence, Registries, Risk Assessment, Risk Factors, ST Elevation Myocardial Infarction diagnosis, ST Elevation Myocardial Infarction mortality, Stents, Ticagrelor adverse effects, Time Factors, Treatment Outcome, Acute Coronary Syndrome therapy, Aspirin administration & dosage, Dual Anti-Platelet Therapy adverse effects, Dual Anti-Platelet Therapy mortality, Non-ST Elevated Myocardial Infarction therapy, Percutaneous Coronary Intervention adverse effects, Percutaneous Coronary Intervention instrumentation, Percutaneous Coronary Intervention mortality, Platelet Aggregation Inhibitors administration & dosage, Prasugrel Hydrochloride administration & dosage, ST Elevation Myocardial Infarction therapy, Ticagrelor administration & dosage
Abstract

Introduction: The benefits of short versus long-term dual antiplatelet therapy (DAPT) based on the third generation P2Y12 antagonists prasugrel or ticagrelor, in patients with acute coronary syndromes treated with percutaneous coronary intervention remain to be clearly defined due to current evidences limited to patients treated with clopidogrel., Methods: All acute coronary syndrome patients from the REgistry of New Antiplatelets in patients with Myocardial Infarction (RENAMI) undergoing percutaneous coronary intervention and treated with aspirin, prasugrel or ticagrelor were stratified according to DAPT duration, that is, shorter than 12 months (D1 group), 12 months (D2 group) and longer than 12 months (D3 group). The three groups were compared before and after propensity score matching. Net adverse clinical events (NACEs), defined as a combination of major adverse cardiac events (MACEs) and major bleedings (including therefore all cause death, myocardial infarction and Bleeding Academic Research Consortium (BARC) 3-5 bleeding), were the primary end points, MACEs (a composite of all cause death and myocardial infarction) the secondary one. Single components of NACEs were co-secondary end points, along with BARC 2-5 bleeding, cardiovascular death and stent thrombosis., Results: A total of 4424 patients from the RENAMI registry with available data on DAPT duration were included in the model. After propensity score matching, 628 patients from each group were selected. After 20 months of follow up, DAPT for 12 months and DAPT for longer than 12 months significantly reduced the risk of NACE (D1 11.6% vs . D2 6.7% vs . D3 7.2%, p  = 0.003) and MACE (10% vs . 6.2% vs . 2.4%, p  < 0.001) compared with DAPT for less than 12 months. These differences were driven by a reduced risk of all cause death (7.8% vs . 1.3% vs . 1.6%, p  < 0.001), cardiovascular death (5.1% vs . 1.0% vs . 1.2%, p  < 0.0001) and recurrent myocardial infarction (8.3% vs . 5.2% vs . 3.5%, p  = 0.002). NACEs were lower with longer DAPT despite a higher risk of BARC 2-5 bleedings (4.6% vs . 5.7% vs . 6.2%, p  = 0.04) and a trend towards a higher risk of BARC 3-5 bleedings (2.4% vs . 3.3% vs . 3.9%, p  = 0.06). These results were not consistent for female patients and those older than 75 years old, due to an increased risk of bleedings which exceeded the reduction in myocardial infarction., Conclusion: In unselected real world acute coronary syndrome patients treated with percutaneous coronary intervention, DAPT with prasugrel or ticagrelor prolonged beyond 12 months markedly reduces fatal and non-fatal ischaemic events, offsetting the increased risk deriving from the higher bleeding risk. On the contrary, patients >75 years old and female ones showed a less favourable risk-benefit ratio for longer DAPT due to excess of bleedings.

Published
2020
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13. Average daily ischemic versus bleeding risk in patients with ACS undergoing PCI: Insights from the BleeMACS and RENAMI registries.

Author

D'Ascenzo F, Biolè C, Raposeiras-Roubin S, Gaido F, Abu-Assi E, Kinnaird T, Ariza-Solé A, Liebetrau C, Manzano-Fernández S, Boccuzzi G, Henriques JPS, Templin C, Wilton SB, Omedè P, Velicki L, Xanthopoulou I, Correia L, Cerrato E, Rognoni A, Fabrizio U, Nuñez-Gil I, Montabone A, Taha S, Fujii T, Durante A, Song X, Gili S, Magnani G, Autelli M, Bongiovanni F, Grosso A, Kawaji T, Blanco PF, Garay A, Quadri G, Alexopoulos D, Queija BC, Huczek Z, Paz RC, González-Juanatey JR, Fernández MC, Nie SP, Pousa IM, Kawashiri MA, Rettegno S, Gallo D, Morbiducci U, Conrotto F, Dominguez-Rodriguez A, Valdés M, Cequier A, Iñiguez-Romo A, Biondi-Zoccai G, Stone GW, and De Ferrari GM

Subjects
Aged, Clopidogrel therapeutic use, Female, Hemorrhage etiology, Humans, Ischemia etiology, Male, Middle Aged, Platelet Aggregation Inhibitors adverse effects, Platelet Aggregation Inhibitors therapeutic use, Postoperative Complications etiology, Prasugrel Hydrochloride therapeutic use, Recurrence, Registries, ST Elevation Myocardial Infarction complications, ST Elevation Myocardial Infarction therapy, Ticagrelor adverse effects, Ticagrelor therapeutic use, Time Factors, Acute Coronary Syndrome therapy, Hemorrhage epidemiology, Ischemia epidemiology, Percutaneous Coronary Intervention adverse effects, Postoperative Complications epidemiology
Abstract

Background: The risk of recurrent ischemia and bleeding after percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) may vary during the first year of follow-up according to clinical presentation, and medical and interventional strategies., Methods: BleeMACS and RENAMI are 2 multicenter registries enrolling patients with ACS treated with PCI and clopidogrel, prasugrel, or ticagrelor. The average daily ischemic and bleeding risks (ADIR and ADBR) in the first year after PCI were the primary end points. The difference between ADBR and ADIR was calculated to estimate the potential excess of bleeding/ischemic events in a given period or specific subgroup., Results: A total of 19,826 patients were included. Overall, in the first year after PCI, the ADBR was 0.008085%, whereas ADIR was 0.008017% (P = .886). In the first 2 weeks ADIR was higher than ADBR (P = .013), especially in patients with ST-segment elevation myocardial infarction or incomplete revascularization. ADIR continued to be, albeit non-significantly, greater than ADBR up to the third month, whereas ADBR became higher, although not significantly, afterward. Patients with incomplete revascularization had an excess in ischemic risk (P = .003), whereas non-ST-segment elevation ACS patients and those on ticagrelor had an excess of bleeding (P = .012 and P = .022, respectively)., Conclusions: In unselected ACS patients, ADIR and ADBR occurred at similar rates within 1 year after PCI. ADIR was greater than ADBR in the first 2 weeks, especially in ST-segment elevation myocardial infarction patients and those with incomplete revascularization. In the first year, ADIR was higher than ADBR in patients with incomplete revascularization, whereas ADBR was higher in non-ST-segment elevation ACS patients and in those discharged on ticagrelor., (Copyright © 2019 Elsevier Inc. All rights reserved.)

Published
2020
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