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6 results on '"Fernández, Diana R."'

1. Open-label phase I/II clinical trial of SARS-CoV-2 receptor binding domain-tetanus toxoid conjugate vaccine (FINLAY-FR-2) in combination with receptor binding domain-protein vaccine (FINLAY-FR-1A) in children

Author

Mesa-Herrera, María Elena, García-Cristiá, Yarmila, Verdecia-Sánchez, Leonor, del Valle Rodríguez, Rafael, Oquendo-de la Cruz, Yudalvies, Álvarez-Montalvo, Daysi, Grillo-Fortún, Randy, López-González, Liset, Galindo, Omaida Fonte, Reyes-González, Yeseni, González-Álvarez, Ana Beatriz, Gorrita-Mora, Linet, Valera-Fernández, Rodrigo, Ontivero-Pino, Ivis, Martínez-Pérez, Marisel, Caballero-Gonzalez, Esperanza, Garcés-Hechavarría, Aniurka, Martínez-Bedoya, Dayle, Medina-Nápoles, Maite, Domínguez-Pentón, Yeney Regla, Cazañas-Quintana, Yadira, Barrios, Thais Fundora, Fernández, Diana R. Hernández, Bergado-Báez, Gretchen, Orosa-Vazquez, Ivette, Pi-Estopiñan, Franciscary, Díaz-Hernández, Marianniz, Cruz-Sui, Otto, Noa-Romero, Enrique, García-López, Arilia, Muro, Sandra Rivadereira, Baro-Roman, Gerardo, Puga-Gómez, Rinaldo, Ricardo-Delgado, Yariset, Rojas-Iriarte, Chaumey, Céspedes-Henriquez, Leyanis, Piedra-Bello, Misleidys, Vega-Mendoza, Dania, Pérez, Noelvia Pestana, Paredes-Moreno, Beatriz, Rodríguez-González, Meiby, Valenzuela-Silva, Carmen, Sánchez-Ramírez, Belinda, Rodríguez-Noda, Laura, Pérez-Nicado, Rocmira, González-Mugica, Raul, Hernández-García, Tays, Fundora-Barrios, Talía, Echevarría, Martha Dubet, Enriquez-Puertas, Juliet María, Infante-Hernández, Yenicet, Palenzuela-Díaz, Ariel, Gato-Orozco, Evelyn, Chappi-Estévez, Yanet, Francisco-Pérez, Julio Cesar, Suarez-Martinez, Miladi, Castillo-Quintana, Ismavy C., Fernandez-Castillo, Sonsire, Climent-Ruiz, Yanet, Santana-Mederos, Darielys, García-Vega, Yanelda, Toledo-Romani, María Eugenia, Doroud, Delaram, Biglari, Alireza, Valdés-Balbín, Yury, García-Rivera, Dagmar, and Vérez-Bencomo, Vicente

Published
2023
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2. Open-label phase I/II clinical trial of SARS-CoV-2 receptor binding domain-tetanus toxoid conjugate vaccine (FINLAY-FR-2) in combination with receptor binding domain-protein vaccine (FINLAY-FR-1A) in children

Author

Puga-Gómez, Rinaldo, primary, Ricardo-Delgado, Yariset, additional, Rojas-Iriarte, Chaumey, additional, Céspedes-Henriquez, Leyanis, additional, Piedra-Bello, Misleidys, additional, Vega-Mendoza, Dania, additional, Pérez, Noelvia Pestana, additional, Paredes-Moreno, Beatriz, additional, Rodríguez-González, Meiby, additional, Valenzuela-Silva, Carmen, additional, Sánchez-Ramírez, Belinda, additional, Rodríguez-Noda, Laura, additional, Pérez-Nicado, Rocmira, additional, González-Mugica, Raul, additional, Hernández-García, Tays, additional, Fundora-Barrios, Talía, additional, Echevarría, Martha Dubet, additional, Enriquez-Puertas, Juliet María, additional, Infante-Hernández, Yenicet, additional, Palenzuela-Díaz, Ariel, additional, Gato-Orozco, Evelyn, additional, Chappi-Estévez, Yanet, additional, Francisco-Pérez, Julio Cesar, additional, Suarez-Martinez, Miladi, additional, Castillo-Quintana, Ismavy C., additional, Fernandez-Castillo, Sonsire, additional, Climent-Ruiz, Yanet, additional, Santana-Mederos, Darielys, additional, García-Vega, Yanelda, additional, Toledo-Romani, María Eugenia, additional, Doroud, Delaram, additional, Biglari, Alireza, additional, Valdés-Balbín, Yury, additional, García-Rivera, Dagmar, additional, Vérez-Bencomo, Vicente, additional, Mesa-Herrera, María Elena, additional, García-Cristiá, Yarmila, additional, Verdecia-Sánchez, Leonor, additional, del Valle Rodríguez, Rafael, additional, Oquendo-de la Cruz, Yudalvies, additional, Álvarez-Montalvo, Daysi, additional, Grillo-Fortún, Randy, additional, López-González, Liset, additional, Galindo, Omaida Fonte, additional, Reyes-González, Yeseni, additional, González-Álvarez, Ana Beatriz, additional, Gorrita-Mora, Linet, additional, Valera-Fernández, Rodrigo, additional, Ontivero-Pino, Ivis, additional, Martínez-Pérez, Marisel, additional, Caballero-Gonzalez, Esperanza, additional, Garcés-Hechavarría, Aniurka, additional, Martínez-Bedoya, Dayle, additional, Medina-Nápoles, Maite, additional, Domínguez-Pentón, Yeney Regla, additional, Cazañas-Quintana, Yadira, additional, Barrios, Thais Fundora, additional, Fernández, Diana R. Hernández, additional, Bergado-Báez, Gretchen, additional, Orosa-Vazquez, Ivette, additional, Pi-Estopiñan, Franciscary, additional, Díaz-Hernández, Marianniz, additional, Cruz-Sui, Otto, additional, Noa-Romero, Enrique, additional, García-López, Arilia, additional, Muro, Sandra Rivadereira, additional, and Baro-Roman, Gerardo, additional

Published
2023
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5. Specific immune response induced in mice by immunization with the human Epidermal Growth Factor Receptor extracellular domain.

Author

Sánchez, Belinda, Aguiar, Yeranddy, Garrido, Greta, Rabasa, Ailem, Fernández, Diana R., Pérez, Rolando, and Fernández, Luis E.

Subjects
*MOLECULAR immune response, *LABORATORY mice, *EPIDERMAL growth factor, *CELL receptors, *IMMUNIZATION, *CELL physiology, *RESEARCH methodology, *AFFINITY chromatography, *CLINICAL immunology, EPITHELIAL cell tumors
Abstract

Epidermal Growth Factor Receptor (EGFR or HER1) is considered a tumor associated antigen. HER1 is overexpressed in many human epithelial tumors and involved in crucial cellular functions for tumor development. For this reason HER1 is considered a good target for cancer immunotherapy and some passive agents are being evaluated in clinical trials. However , HER1-based active immunotherapy has not been clinically explored. To develop an active immunotherapy approach based on HER1 for the treatment of HER1+ cancer patients, we cloned and expressed in mammalian cells the HER1 extracellular domain protein (HER1-ECD), which was specifically recognized by an anti- EGFR monoclonal antibody. HER1-ECD was purified by affinity chromatography and adjuvated in Very Small Size Proteoliposomes (VSSP) or Complete Freund adjuvant to immunize C57BL/6 mice. Immunization elicited specific humoral and cellular immune response. The polyclonal antibodies induced by immunization recognized the full length HER1 on the surface of a lung tumor cell line. These results suggest that HER1-ECD could be an appropriated antigen to induce specific immune response in patients with HER1+ tumors. [ABSTRACT FROM AUTHOR]

Published
2008

6. [Prenatal diagnosis of congenital heart disease by echocardiography in Matanzas Province, Cuba, from 1990 to 1995].

Author

González Font AE, Carrete Ramírez FA, and González Fernández DR

Subjects
Cuba, Echocardiography methods, Female, Fetal Diseases diagnostic imaging, Fetal Heart abnormalities, Fetal Heart diagnostic imaging, Humans, Infant, Newborn, Pregnancy, Pregnancy Outcome, Heart Defects, Congenital diagnostic imaging, Prenatal Diagnosis, Ultrasonography, Prenatal methods
Abstract

We analyze the intra-uterine diagnoses of congenital cardiopathies performed by means of fetal echocardiographies from 1990 to 1995 in Matanzas, Cuba. All patients were examined in search of risk factors and indicators; 39 complex cardiopathies were detected, the most frequent ones were univentricular heart, hypoplasia of the left ventricle, and pulmonary atresia. Significant references were an abnormal image of the four cavities and the associated fetal anomalies; 66% of the malformations were diagnosed before week 24 of gestation. It was observed that the group of patients not diagnosed prenatally had a significant perinatal mortality. Although 32% of the newborns' complex cardiopathies in that period were diagnosed prenatally, it is necessary to improve this result aimed at reducing the morbidity and mortality due to these anomalies, offering the best survival conditions at the time of birth.

Published
2005

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