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283 results on '"Ferlazzo, Nadia"'

13. Changes in the Biomarkers of Oxidative/Nitrosative Stress and Endothelial Dysfunction Are Associated with Cardiovascular Risk in Periodontitis Patients

Author

Ferlazzo, Nadia, primary, Currò, Monica, additional, Isola, Gaetano, additional, Maggio, Silvia, additional, Bertuccio, Maria Paola, additional, Trovato-Salinaro, Angela, additional, Matarese, Giovanni, additional, Alibrandi, Angela, additional, Caccamo, Daniela, additional, and Ientile, Riccardo, additional

Published
2021
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19. A Flavonoid-Rich Extract from Bergamot Juice, Alone or in Association with Curcumin and Resveratrol, Shows Protective Effects in a Murine Model of Cadmium-Induced Testicular Injury

Author

Ferlazzo, Nadia, primary, Micali, Antonio, additional, Marini, Herbert Ryan, additional, Freni, Josè, additional, Santoro, Giuseppe, additional, Puzzolo, Domenico, additional, Squadrito, Francesco, additional, Pallio, Giovanni, additional, Navarra, Michele, additional, Cirmi, Santa, additional, and Minutoli, Letteria, additional

Published
2021
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22. Is Melatonin the Cornucopia of the 21st Century?

Author

Ferlazzo, Nadia, primary, Andolina, Giulia, additional, Cannata, Attilio, additional, Costanzo, Maria Giovanna, additional, Rizzo, Valentina, additional, Currò, Monica, additional, Ientile, Riccardo, additional, and Caccamo, Daniela, additional

Published
2020
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29. Correction: Mechanisms underlying the anti-tumoral effects of citrus bergamia juice (PLoS ONE (2013) 8:4 (e61484) DOI: 10.1371/journal.pone.0061484)

Author

Monache, Simona Delle, Sanità, Patrizia, Trapasso, Elena, Ursino, Maria Rita, Dugo, Paola, Russo, Marina, Ferlazzo, Nadia, Calapai, Gioacchino, Angelucci, Adriano, and Navarra, Michele

Subjects
Genetics and Molecular Biology (all), Agricultural and Biological Sciences (all), Biochemistry, Genetics and Molecular Biology (all), Biochemistry
Published
2018

34. Stable Ozonides with Vitamin E Acetate versus Corticosteroid in the Treatment of Lichen Sclerosus in Foreskin: Evaluation of Effects on Inflammation

Author

Russo, Tiziana, primary, Currò, Monica, additional, Ferlazzo, Nadia, additional, Caccamo, Daniela, additional, Perrone, Patrizia, additional, Arena, Salvatore, additional, Antonelli, Enrica, additional, Antonuccio, Pietro, additional, Ientile, Riccardo, additional, Romeo, Carmelo, additional, and Impellizzeri, Pietro, additional

Published
2019
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36. NF-kappaB activation is associated with homocysteine-induced injury in Neuro2a cells

Author

Ientile Riccardo, Parisi Giulia, Currò Monica, Condello Salvatore, Ferlazzo Nadia, and Caccamo Daniela

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurophysiology and neuropsychology, QP351-495
Abstract

Abstract Background Perinatal exposure to hyperhomocysteinemia might disturb neurogenesis during brain development and growth. Also, high levels of homocysteine trigger neurodegeneration in several experimental models. However, the putative mechanisms of homocysteine-induced toxicity in the developing nervous system have poorly been elucidated. This study was aimed to investigate homocysteine effects in undifferentiated neuroblastoma cells, Neuro2a. Results A 4 h exposure to homocysteine in a concentration range of 10–100 μM did not affect cell viability and ROS production in Neuro2a cell cultures. Instead, ROS levels were increased by two-three folds in cells treated with 250 μM and 500 μM homocysteine, respectively, in comparison with control cells. Also, the highest homocysteine dose significantly reduced the viable cell number by 40%. Notably, the treatment with homocysteine (250 μM–500 μM) in the presence of antioxidants, such as N-acetylcysteine and IRFI 016, a synthetic α-tocopherol analogue, recovered cell viability and significantly reduced homocysteine-evoked increases in ROS production. Moreover, antioxidants, particularly IRFI 016, were able to counteract NF-κB activation induced by 250 μM homocysteine. Cell treatment with 250 μM homocysteine also triggered the onset of apoptosis, as demonstrated by the increased expression of early apoptotic markers such as Bax, caspase-3 and p53. In contrast, Bcl2 expression was not affected by homocysteine exposure. Interestingly, the specific inhibition of NF-κB nuclear translocation by the synthetic peptide SN50 was able to almost completely suppress the homocysteine-evoked rises in pro-apoptotic protein expression as well as in caspase-3 activity. Further, also IRFI 016 and N-acetylcysteine were able to significantly reduce caspase-3 activation induced by homocysteine treatment. Conclusion These observations suggest an involvement of redox state alterations and activated NF-κB in apoptosis onset triggered by homocysteine in neuroblastoma cells Neuro2a. However, further investigations are needed to characterize molecular events involved in the NF-κB activation induced by homocysteine.

Published
2008
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37. CO2 Pneumoperitoneum Effects on Molecular Markers of Tumor Invasiveness in SH-SY5Y Neuroblastoma Cells.

Author

Montalto, Angela Simona, Currò, Monica, Russo, Tiziana, Ferlazzo, Nadia, Caccamo, Daniela, Ientile, Riccardo, Romeo, Carmelo, and Impellizzeri, Pietro

Subjects
NEUROBLASTOMA, CANCER invasiveness, TUMOR markers, MESSENGER RNA, VASCULAR endothelial growth factors, PNEUMOPERITONEUM, ENDOSCOPIC surgery, PROTEOLYTIC enzymes, CELL physiology, RNA, CELLULAR signal transduction, CARBON dioxide, CELL lines
Abstract

Introduction:  CO2 pneumoperitoneum can influence the biological behavior of neuroblastoma (NB). Angiogenesis and genetic features are responsible for malignant phenotype of this tumor. We examined the CO2 effects on N-Myc, vascular endothelial growth factor (VEGF), and matrix metalloproteinase-2 (MMP-2) expression as critical biomarkers of tumor invasiveness, in NB cells without N-Myc amplification.Materials and Methods:  SH-SY5Y cells were exposed to CO2 (100%) at 15 mm Hg pressure for 4 hours and then moved to normal condition for 24 hours. Control cells were incubated with 5% CO2 for the same time. In control and CO2-exposed cells, the messenger ribonucleic acid (mRNA) levels of hypoxia-inducible factor (HIF)-1α, HIF-2α, VEGF-A, and MMP-2 were quantified by real-time polymerase chain reaction. N-Myc expression was evaluated by Western blot analysis.Results:  The exposure to 15 mm Hg CO2 (100%) for 4 hours induced an increase in HIF-1α, but not in HIF-2α, mRNA levels. No differences were observed in N-Myc expression between exposed and control cells at each incubation time. Similarly, no significant differences were found for VEGF-A and MMP-2 transcript levels. In CO2 exposed cells, we observed only a slight increase in both VEGF-A and MMP-2 mRNA levels after 4 and 24 hours in comparison to controls.Conclusion:  In our study, the hypoxic environment induced by CO2 exposure does not affect the expression of critical biomarkers of NB aggressiveness, such as N-Myc, VEGF, and MMP-2, in human SH-SY5Y NB cells without N-Myc amplification. These data suggest that CO2 pneumoperitoneum might not adversely impact NB cell invasiveness; however, it is necessary to evaluate these effects in others in vitro and in vivo models. [ABSTRACT FROM AUTHOR]

Published
2020
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38. Ex vivo evaluation of the effects of a white grape juice extract on lymphocytic mitochondrial functions.

Author

Visalli, Giuseppa, Ferlazzo, Nadia, Facciola, Alessio, Picerno, Isa, Navarra, Michele, and Di Pietroa, Angela

Subjects
GRAPE juice, AGE groups, OLD age, EXTRACTS, AGE factors in disease
Abstract

The physio-pathological role of mitochondria in aging and age-related diseases has stimulated the search for compounds able to promote mitochondrial functionality. Our study was designed to evaluate the effect of a white grape juice extract (WGJe) on mitochondrial activity, in an ex vivo experimental model consisting of activated lymphocytes obtained from a younger age group and an older age group of subjects. WGJe steadily decreased the lymphocytic mitochondrial mass in the older subjects, without a relevant effect in their younger counterpart, and significantly enhanced Dwm in both groups investigated. Finally, WGJe reduced the endogenous mitochondrial production of H2O2 in all subjects. The results support the potential use of WGJe to improve mitochondrial functionality, thus maintaining human health and slowing down aging. [ABSTRACT FROM AUTHOR]

Published
2020
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41. Anti-Inflammatory and Tissue Regenerative Effects of Topical Treatment with Ozonated Olive Oil/Vitamin E Acetate in Balanitis Xerotica Obliterans

Author

Currò, Monica, primary, Russo, Tiziana, additional, Ferlazzo, Nadia, additional, Caccamo, Daniela, additional, Antonuccio, Pietro, additional, Arena, Salvatore, additional, Parisi, Saveria, additional, Perrone, Patrizia, additional, Ientile, Riccardo, additional, Romeo, Carmelo, additional, and Impellizzeri, Pietro, additional

Published
2018
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49. The link between the AMPK/SIRT1 axis and a flavonoid-rich extract of Citrus bergamia juice: A cell-free, in silico, and in vitro study.

Author

Maugeri, Alessandro, Ferlazzo, Nadia, De Luca, Laura, Gitto, Rosaria, and Navarra, Michele

Abstract

A previous report indicated that the flavonoid-rich extract of bergamot juice (BJe) exerts an anti-inflammatory effect through the activation of SIRT1 in leukemic monocytes THP-1 exposed to lipopolysaccharide (LPS). In this study, we deeply investigate the mode of action of BJe, along with its major flavonoids on SIRT1 through cell-free, in silico, and in vitro experimental models. In the cell-free assay, all the tested compounds as well as the whole BJe inhibited the deacetylase activity of SIRT1. This finding was reinforced by the results of the in silico study. In THP-1 cells exposed to LPS, a reduction of SIRT1 activity was observed, effect that was reverted by the pre-incubation with either BJe or its major flavonoids. This effect was also observed at gene level. Employing an activator and an inhibitor of AMP-activated protein kinase (AMPK; AICAR and dorsomorphin, respectively), we discovered its involvement in the activation of SIRT1 elicited by BJe or its major flavonoids in whole cell. Our study indicates the dual role of BJe and its components, depending on the employed experimental model as well as reveals their mode of action on the AMPK/SIRT1 axis, suggesting their role as promising candidates in pathologies in which this axis is implied. [ABSTRACT FROM AUTHOR]

Published
2019
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