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4. Improvement in cognitive impairment following a 12‐week aerobic exercise intervention in individuals with non‐cirrhotic chronic hepatitis C

Author

O’Gorman, Philip, primary, Strahan, Orla, additional, Ferguson, Damien, additional, Monaghan, Ann, additional, Kennedy, Megan, additional, Forde, Cuisle, additional, Melo, Ashanty M., additional, Doherty, Derek G., additional, O’Brien, Kelly K., additional, McKiernan, Susan, additional, Kenny, Rose Anne, additional, Coen, Robert, additional, Doherty, Colin, additional, Bergin, Colm, additional, Gormley, John, additional, and Norris, Suzanne, additional

Published
2021
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8. FRI-245-Improvement in cognitive impairment following 12 weeks of aerobic exercise in individuals with non-cirrhotic, chronic hepatitis C

Author

O’gorman, Philip, primary, Ferguson, Damien, additional, Strahan, Orla, additional, Monaghan, Ann, additional, Kennedy, Megan, additional, Bergin, Colm, additional, Mckiernan, Susan, additional, Coen, Robert, additional, Doherty, Colin, additional, Forde, Cuisle, additional, Gormley, John, additional, and Norris, Suzanne, additional

Published
2019
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10. Improvement in cognitive impairment following a 12‐week aerobic exercise intervention in individuals with non‐cirrhotic chronic hepatitis C.

Author

O'Gorman, Philip, Strahan, Orla, Ferguson, Damien, Monaghan, Ann, Kennedy, Megan, Forde, Cuisle, Melo, Ashanty M., Doherty, Derek G., O'Brien, Kelly K., McKiernan, Susan, Kenny, Rose Anne, Coen, Robert, Doherty, Colin, Bergin, Colm, Gormley, John, and Norris, Suzanne

Subjects
CHRONIC hepatitis C, COGNITION disorders, TRAIL Making Test, MONTREAL Cognitive Assessment, AEROBIC exercises, CARDIOPULMONARY fitness, CARDIOVASCULAR fitness
Abstract

Cognitive impairment occurs in 30%–50% of patients with non‐cirrhotic chronic hepatitis C virus (HCV) infection. Exercise is beneficial in preventing and treating cognitive impairment and cardiometabolic abnormalities in many chronic inflammatory diseases, but there are few studies investigating the impact of exercise in HCV infection. The study aimed to assess the effect of a 12‐week aerobic exercise intervention on cognition and extrahepatic manifestations in individuals with HCV. In this nonrandomized controlled pilot study, individuals with HCV participated in a 12‐week aerobic exercise intervention. Outcome measures included cognition (Montreal Cognitive Assessment [MOCA], Trail Making Test A & B [TMT‐A; TMT‐B], Digit Symbol Test [DST]), cardiorespiratory fitness (estimated V˙O2max), physical activity (accelerometry), anthropometry, quality of life (depression; fatigue; sleep quality) and biochemical markers. Outcomes were assessed at baseline (T0), intervention completion (T1) and 12 weeks after intervention completion (T2). Thirty‐one patients completed the study (exercise group n = 13, control group n = 18). In the exercise group, cognition improved at T1 in the TMT‐A (31% mean improvement, p = 0.019), TMT‐B (15% mean improvement, p = 0.012) time and MOCA (14% mean improvement, p ≤ 0.001). These improvements were not maintained at T2. Depression (p = 0.038), sleep quality (p = 0.002), fatigue (p = 0.037) and estimated V˙O2max (7.8 mL kg−1 min−1 [22%] mean increase, p = 0.004) also improved at T1. In conclusion, this study demonstrates the benefits of a 12‐week aerobic exercise intervention in improving cognition, quality of life and cardiorespiratory fitness in individuals with HCV. Larger studies are needed to confirm these findings and strategies for continued exercise engagement in individuals with HCV are warranted for sustained benefits. [ABSTRACT FROM AUTHOR]

Published
2021
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11. Very-late-onset Friedreich's ataxia: diagnosis in a kindred with late-onset cerebellar ataxia.

Author

Fearon, Conor, Lonergan, Roisin, Ferguson, Damien, Byrne, Susan, Bradley, David, Langan, Yvonne, and Redmond, Janice

Subjects
CEREBELLAR ataxia, DIFFERENTIAL diagnosis, DIAGNOSTIC errors, FRIEDREICH'S ataxia, MAGNETIC resonance imaging, GENETIC testing, DELAYED onset of disease, SYMPTOMS
Abstract

Friedreich's ataxia is classically considered a disease with onset in the first or second decade. However, late-onset (age of onset 25-39 years) and very-late-onset (age of onset >40 years) forms do occur rarely. Misdiagnosis is common, particularly because the later onset forms of Friedreich's ataxia commonly do not show characteristic features of the disorder (areflexia, dysarthria, sensory neuropathy, extensor plantars, amyotrophy, cardiac involvement, diabetes mellitus, scoliosis). Also, there may be atypical features such as spasticity, brisk reflexes and laryngeal dystonia. We present the clinical, imaging and genetic findings of a kindred with very-late-onset Friedreich's ataxia and discuss the pitfalls and risk of misdiagnosis. [ABSTRACT FROM AUTHOR]

Published
2020
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13. A study of clinical strains of Pseudomonas Aeruginosa and the investigation of antibiotic resistance mechanisms in the multidrug resistant strain PA13

Author

Ferguson, Damien

Subjects
polycyclic compounds, bacteria, biochemical phenomena, metabolism, and nutrition, Microbiology, Biotechnology
Abstract

Thirteen clinical strains of bacteria from two Irish hospitals were identified as Pseudomonas aeruginosa using classical methods, API 20NE and Biolog GN. Their identification was confirmed by 16S rRNA gene sequencing. The antibiotic resistance profiles of the isolates were determined against forty-one antibiotics belonging to eleven distinct classes. All the isolates were resistant to penicillin G, ampicillin, cephalothin, cloxacillin, oxacillin, amoxicillin, cefotaxime, moxalactam, sulphatriad cotrimoxazole, chloramphenicol and tetracycline. All were sensitive to ceftazidime, piperacillin-tazobactam, cefepime, ceftriaxone, meropenem, aztreonam, amikacin, apramycin, butirosin A, lividomycin and colistin sulphate. One of the isolates, PA13, was resistant to a further fourteen antibiotics and was identified as a multidrug resistant strain. A 2.2 kbp PCR product was amplified from P. aeruginosa PA13. When this product was sequenced it was found to contain four open reading frames. BLASTN analysis identified these as being an integrase gene (ORF1), an aminoglycoside acetyltransferase gene, aac(6’)-Ib (ORF2), an oxacillinase gene (ORF3) and a quaternary ammonium compound resistance gene (ORF4). The presence of the integrase gene and the quaternary ammonium compound gene suggested that the genes were on a Class 1 integron. The acetyltransferase aac(6’)-Ib gene contained the mutant type of the enzyme with a leucine substitution by serine at position 119. Two expression vectors were chosen to investigate the novel oxacillinase gene. One was a commercially available vector, pET-28a (Novagen) and the other was an in-house vector, pPC. The gene was successfully cloned into both vectors. Following induction the desired protein was not expressed in either the soluble or insoluble fractions.

Published
2008

14. Biodegradable, non-bactericidal oxygen-functionalised imidazolium esters: A step towards ‘greener’ ionic liquids

Author

Morrissey, Saibh, Pegot, Bruce, Coleman, Deborah, García Ramón, María Teresa, Ferguson, Damien, Quilty, Brid, Gathergood, Nicholas, Morrissey, Saibh, Pegot, Bruce, Coleman, Deborah, García Ramón, María Teresa, Ferguson, Damien, Quilty, Brid, and Gathergood, Nicholas

Abstract

A series of imidazolium ionic liquids was prepared and screened against 7 bacterial strains. The incorporation of ether groups into the ester side-chain significantly reduced the toxicity compared with alkyl ester derivatives. Biodegradation data are also presented for 15 of the ionic liquids—including 6 examples which can be classed as readily biodegradable.

Published
2009

17. FRI-245-Improvement in cognitive impairment following 12 weeks of aerobic exercise in individuals with non-cirrhotic, chronic hepatitis C.

Author

O'gorman, Philip, Ferguson, Damien, Strahan, Orla, Monaghan, Ann, Kennedy, Megan, Bergin, Colm, Mckiernan, Susan, Coen, Robert, Doherty, Colin, Forde, Cuisle, Gormley, John, and Norris, Suzanne

Subjects
*CHRONIC hepatitis C, *AEROBIC exercises, *TREATMENT effectiveness, *EXERCISE therapy, *COGNITION disorders, *COGNITION disorders treatment
Published
2019
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