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219 results on '"Ferguson, D. J. P."'

9. Ultrastructural characterization of host–parasite interactions of Plasmodium coatneyi in rhesus macaques.

Author

Lombardini, E. D., Malleret, B., Rungojn, A., Popruk, N., Kaewamatawong, T., Brown, A. E., Turner, G. D. H., Russell, B., and Ferguson, D. J. P.

Subjects
RHESUS monkeys, MACAQUES, PLASMODIUM, PARASITES, ERYTHROCYTES, PLASMODIUM falciparum, ELECTRON microscopy, BLOOD vessels
Abstract

Plasmodium coatneyi has been proposed as an animal model for human Plasmodium falciparum malaria as it appears to replicate many aspects of pathogenesis and clinical symptomology. As part of the ongoing evaluation of the rhesus macaque model of severe malaria, a detailed ultrastructural analysis of the interaction between the parasite and both the host erythrocytes and the microvasculature was undertaken. Tissue (brain, heart and kidney) from splenectomized rhesus macaques and blood from spleen-intact animals infected with P. coatneyi were examined by electron microscopy. In all three tissues, similar interactions (sequestration) between infected red blood cells (iRBC) and blood vessels were observed with evidence of rosette and auto-agglutinate formation. The iRBCs possessed caveolae similar to P. vivax and knob-like structures similar to P. falciparum. However, the knobs often appeared incompletely formed in the splenectomized animals in contrast to the intact knobs exhibited by spleen intact animals. Plasmodium coatneyi infection in the monkey replicates many of the ultrastructural features particularly associated with P. falciparum in humans and as such supports its use as a suitable animal model. However, the possible effect on host–parasite interactions and the pathogenesis of disease due to the use of splenectomized animals needs to be taken into consideration. [ABSTRACT FROM AUTHOR]

Published
2022
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12. Cabochonicus, a new genus for species of gemmate megaspores previously referred to Verrutriletes

Author

Batten, D. J. and Ferguson, D. J. P.

Abstract

Several species of Mesozoic megaspores that are sculptured with globular, often gemmate elements are sufficiently distinct from most verrucate forms to warrant their inclusion in a genus other than Verrutriletes. Cabochonicus is erected to accommodate them with C. (al. Verrutriletes) carbunculus as the type species. The form of the gemmae, which have a glossy appearance, has been the subject of past debate with one interpretation being that they are the manifestation of fungal attack rather than sculpture. Evidence from ultrastructural studies suggests, however, that they are exinal excrescences. The spores are assumed to be the products of heterosporous lycopods and the structure of the wall layers may indicate selaginellalean affinities. The plants are more likely to have been terrestrial than aquatic or semi-aquatic.

Published
2018

28. Light and electron microscopical observations of the effects of high-density lipoprotein on growth of Plasmodium falciparum in vitro

Author

Imrie, H., Ferguson, D. J. P., Carter, M., Drain, J., Schiflett, A., Hajduk, Stephen L., Day, K. P., Imrie, H., Ferguson, D. J. P., Carter, M., Drain, J., Schiflett, A., Hajduk, Stephen L., and Day, K. P.

Abstract

Author Posting. © Cambridge University Press, 2004. This article is posted here by permission of Cambridge University Press for personal use, not for redistribution. The definitive version was published in Parasitology 128 (2004): 577-584, doi:10.1017/S0031182004005025., Human serum high-density lipoprotein (HDL) is necessary and sufficient for the short-term maintenance of Plasmodium falciparum in in vitro culture. However, at high concentrations it is toxic to the parasite. A heat-labile component is apparently responsible for the stage-specific toxicity to parasites within infected erythrocytes 12–42 h after invasion, i.e. during trophozoite maturation. The effects of HDL on parasite metabolism (as determined by nucleic acid synthesis) are evident at about 30 h after invasion. Parasites treated with HDL show gross abnormalities by light and electron microscopy., Professor Hajduk was supported by NIH. Professor Day was supported by a Research Leave Fellowship from The Wellcome Trust. Dr Imrie and Ms Carter were supported by Programme Grant funding awarded to Professor Day from The Wellcome Trust. Dr Ferguson was supported by an equipment grant from The Wellcome Trust.

Published
2005

31. Can cytoplasmic nucleophosmin be detected by immunocytochemical staining of cell smears in acute myeloid leukemia?

Author

Mattsson, G., primary, Turner, S. H., additional, Cordell, J., additional, Ferguson, D. J. P., additional, Schuh, A., additional, Grimwade, L. F., additional, Bench, A. J., additional, Weinberg, O. K., additional, Marafioti, T., additional, George, T. I., additional, Arber, D. A., additional, Erber, W. N., additional, and Mason, D. Y., additional

Published
2009
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