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1. Wastewater toxicity removal: Integrated chemical and effect-based monitoring of full-scale conventional activated sludge and membrane bioreactor plants

Author

Bertanza, G, Steimberg, N, Pedrazzani, R, Boniotti, J, Ceretti, E, Mazzoleni, G, Menghini, M, Urani, C, Zerbini, I, Feretti, D, Bertanza G., Steimberg N., Pedrazzani R., Boniotti J., Ceretti E., Mazzoleni G., Menghini M., Urani C., Zerbini I., Feretti D., Bertanza, G, Steimberg, N, Pedrazzani, R, Boniotti, J, Ceretti, E, Mazzoleni, G, Menghini, M, Urani, C, Zerbini, I, Feretti, D, Bertanza G., Steimberg N., Pedrazzani R., Boniotti J., Ceretti E., Mazzoleni G., Menghini M., Urani C., Zerbini I., and Feretti D.

Abstract

The literature is currently lacking effect-based monitoring studies targeted at evaluating the performance of full-scale membrane bioreactor plants. In this research, a monitoring campaign was performed at a full-scale wastewater treatment facility with two parallel lines (traditional activated sludge and membrane bioreactor). Beside the standard parameters (COD, nitrogen, phosphorus, and metals), 6 polynuclear aromatic hydrocarbons, 29 insecticides, 2 herbicides, and 3 endocrine disrupting compounds were measured. A multi-tiered battery of bioassays complemented the investigation, targeting different toxic modes of action and employing various biological systems (uni/multicellular, prokaryotes/eukaryotes, trophic level occupation). A traffic light scoring approach was proposed to quickly visualize the impact of treatment on overall toxicity that occurred after the exposure to raw and concentrated wastewater. Analysis of the effluents of the CAS and MBR lines show very good performance of the two systems for removal of organic micropollutants and metals. The most noticeable differences between CAS and MBR occurred in the concentration of suspended solids; chemical analyses did not show major differences. On the other hand, bioassays demonstrated better performance for the MBR. Both treatment lines complied with the Italian law's “ecotoxicity standard for effluent discharge in surface water”. Yet, residual biological activity was still detected, demonstrating the adequacy and sensitivity of the toxicological tools, which, by their inherent nature, allow the overall effects of complex mixtures to be taken into account.

Published
2022

2. Beyond the Black Box of Life Cycle Assessment in Wastewater Treatment Plants: Which Help from Bioassays?

Author

Menghini, M, Pedrazzani, R, Feretti, D, Mazzoleni, G, Steimberg, N, Urani, C, Zerbini, I, Bertanza, G, Menghini, Michele, Pedrazzani, Roberta, Feretti, Donatella, Mazzoleni, Giovanna, Steimberg, Nathalie, Urani, Chiara, Zerbini, Ilaria, Bertanza, Giorgio, Menghini, M, Pedrazzani, R, Feretti, D, Mazzoleni, G, Steimberg, N, Urani, C, Zerbini, I, Bertanza, G, Menghini, Michele, Pedrazzani, Roberta, Feretti, Donatella, Mazzoleni, Giovanna, Steimberg, Nathalie, Urani, Chiara, Zerbini, Ilaria, and Bertanza, Giorgio

Abstract

The assessment of the environmental footprint of an organization or product is based on methods published by the European Union Joint Research Centre, which take 16 impact areas into account. Among the listed categories are human and freshwater ecosystem toxicities. Standard protocols utilize just chemical parameters as input data, hindering the determination of the full impact of complex mixes, such as pollutants released into the environment. Biological assays enable us to overcome this gap: in the present work, assays were employed to determine both baseline and specific toxicity to aquatic species (green algae, luminescent bacteria, and crustacean cladocera) as well as specific toxicity (mutagenicity and carcinogenicity). Ecological footprint was estimated with regard to the impact categories “freshwater toxicity” and “human cancer toxicity” following the standard methodology. In parallel, the impact on the above categories was estimated using the results of biological assays as input. Standard and bioassay-based results are not always congruent, and conventional methods generally underestimate the effects. Likewise, the choice of reference substance (metals or organics) influences the quantification of impact. Appropriate batteries of biological assays could therefore be utilized to complement LCA (Life Cycle Assessment) techniques in order to make them more sensitive when considering toxicity in mid-term impact categories.

Published
2023

7. Modelli, strumenti e metodi per valutare l’impatto delle opere di ingegneria sanitaria sull’ambiente e la salute umana: il trattamento delle acque reflue (WAT_CHALLENGE)

Author

Feretti, D, Pedrazzani, R, Ziliani, E, Steimberg, N, Urani, C, Zerbini, I, Ceretti, E, Mazzoleni, G, Bertanza, G, Feretti, D, Pedrazzani, R, Ziliani, E, Steimberg, N, Urani, C, Zerbini, I, Ceretti, E, Mazzoleni, G, and Bertanza, G

Subjects
saggi biologici, cancerogenesi, acque reflue, WAT_CHALLENGE, mutagensi, BIO/06 - ANATOMIA COMPARATA E CITOLOGIA
Abstract

Introduzione La gestione delle opere afferenti al ciclo idrico integrato può avvalersi di strumenti consolidati e, spesso, standardizzati nell’ambito dei sistemi di gestione della qualità, al fine di perseguire obiettivi di efficienza e sostenibilità (tecnico-economica e ambientale). Tuttavia, l’individuazione della soluzione ottimale implica talvolta la necessità di confrontare e valutare innumerevoli fattori, spesso tra loro contrastanti: per esempio, nel caso della depurazione delle acque reflue, l’obiettivo di rimozione degli inquinanti dalle emissioni liquide potrebbe pesare negativamente sui consumi energetici. Sarebbe utile disporre di uno strumento che consenta sia di definire gli obiettivi, sia di misurare idonei parametri che ne descrivano il raggiungimento, e, infine, di confrontare tra loro il valore di tali parametri, avvalendosi di criteri per l’attribuzione di un peso a questi ultimi. Scopo del progetto è lo sviluppo di protocolli e strumenti integrati per valutare possibili effetti di un’opera (segnatamente, impianti di depurazione delle acque reflue) sulle matrici ambientali e sulla salute umana, fornendo criteri utili al processo decisionale. Materiali e metodi Influenti ed effluenti di due impianti di depurazione di acque reflue urbane sono stati analizzati mediante una batteria di saggi biologici in organismi posti a diversi livelli trofici (batteri, alghe unicellulari, crostacei cladoceri, macrofite, cellule murine e umane) e differenti endpoint (tossicità aspecifica, genotossicità, interferenza endocrina, cancerogenicità). Sulla base della valenza tossicologica dei diversi saggi è stato definito un protocollo di valutazione. Risultati Dai diversi test è emerso un quadro assai complesso. Le acque in entrata agli impianti sono dotate di molta tossicità, che in generale diminuisce in uscita. Relativamente agli interferenti endocrini il trattamento non sembra ridurne la concentrazione. Per quanto riguarda le sostanze che agiscono danneggiando il DNA sembra che non ci siano sostanze mutagene per batteri e cellule vegetali ma siano invece presenti, sia in entrata che in uscita, sostanze in grado di interagire con il DNA di cellule umane. Conclusioni Il monitoraggio dei contaminanti ambientali (tossici, genotossici, cancerogeni e interferenti endocrini) presenti negli effluenti degli impianti di depurazione mediante un approccio integrato, applicando diversi test in differenti tipi cellulari, permette una migliore valutazione dell’impatto sull’ambiente e della possibile esposizione umana a composti pericolosi per la salute. La modellizzazione di questi dati potrebbe essere un utile ausilio per i gestori degli impianti di trattamento. (Finanziato dall’Università di Brescia-Bando “Health and Wealth”).

Published
2019

8. Results from the European Union MAPEC_LIFE cohort study on air pollution and chromosomal damage in children: are public health policies sufficiently protective?

Author

Ceretti, E., Donato, F., Zani, C., Villarini, M., Verani, M., De Donno, A., Bonetta, S., Feretti, D., Carducci, A., Idolo, A., Carraro, E., Covolo, L., Moretti, M., Palomba, G., Grassi, T., Bonetti, A., Bonizzoni, S., Biggeri, A., Gelatti, U., Festa, A., Viola, G. C. V., Zerbini, I., Fatigoni, C., Levorato, S., Monarca, S., Salvatori, T., Vannini, S., Donzelli, G., Bagordo, F., De Giorgi, M., Guido, M., Panico, A., Serio, F., Tumolo, M. R., Gea, M., Gilli, G., Pignata, C., Schiliro, T., Romanazzi, V., Furia, C., Bruni, B., and Casini, B.

Subjects
medicine.medical_specialty, Buccal swab, Air pollution, 010501 environmental sciences, medicine.disease_cause, 01 natural sciences, 03 medical and health sciences, symbols.namesake, 0302 clinical medicine, Environmental health, Epidemiology, medicine, media_common.cataloged_instance, Air quality policy, 030212 general & internal medicine, Poisson regression, European union, Air pollution exposure, Biomarkers of early effects, Children, Chromosomal damage, Air quality index, 0105 earth and related environmental sciences, media_common, Pollutant, business.industry, Pollution, symbols, business, Cohort study
Abstract

Following publication of the original article [1], the typesetters have missed to add the below listed study group author names in XML in author group section. The study group authors have been added to the author group and are presented correctly in this correction article. A minor change has been made to the electronic supplementary files by removing the yellow highlights and included in this correction. Study Group Authors: Andrea Festa1 Gaia Claudia Viviana Viola1 Ilaria Zerbini1 Cristina Fatigoni2 Sara Levorato2 Silvano Monarca2 Tania Salvatori2 Samuele Vannini2 Gabriele Donzelli3 Francesco Bagordo4 Mattia De Giorgi4 Marcello Guido4 Alessandra Panico4 Francesca Serio4 Maria Rosaria Tumolo4 Silvia Bonetta5 Marta Gea5 Giorgio Gilli5 Cristina Pignata5 Tiziana Schilirò5 Valeria Romanazzi5 Camilla Furia6 Beatrice Bruni7 Beatrice Casini7 Study Group Author Affiliations: 1Department of Medical and Surgical Specialties, Radiological Science and Public Health, University of Brescia, 11 Viale Europa, 25123 Brescia, Italy 2Department of Pharmaceutical Sciences, Unit of Public Health, University of Perugia, Via del Giochetto, 06122 Perugia, Italy 3Department of Biology, University of Pisa, 35/39 Via S. Zeno, 56127 Pisa, Italy 4Department of Biological and Environmental Science and Technology, University of Salento, 165 Via Monteroni, 73100 Lecce, Italy 5Department of Public Health and Pediatrics, University of Torino, 94 Piazza Polonia, 10126 Turin, Italy 6Brescia Municipality, 1 Piazza Repubblica, 25100 Brescia, Italy 7Department of Translational Research, N.T.M.S., University of Pisa, 35/39 Via S. Zeno, 56127 Pisa, Italy Author details 1 Department of Medical and Surgical Specialties, Radiological Science and Public Health, University of Brescia, 11 Viale Europa, 25123 Brescia, Italy. 2 Department of Pharmaceutical Sciences, Unit of Public Health, University of Perugia, Via del Giochetto, 06122 Perugia, Italy. 3 Department of Biology, University of Pisa, 35/39 Via S. Zeno, 56127 Pisa, Italy. 4 Department of Biological and Environmental Science and Technology, University of Salento, 165 Via Monteroni, 73100 Lecce, Italy. 5 Department of Public Health and Pediatrics, University of Torino, 94 Piazza Polonia, 10126 Turin, Italy. 6 Multi-sector and Technological Service Centre - CSMT Gestione S.c.a.r.l, 45 Via Branze, 25123 Brescia, Italy. 7 Brescia Municipality, 1 Piazza Repubblica, 25100 Brescia, Italy. 8 Department of Statistic, Computer Science, Applications, University of Florence, 59 Viale Morgagni, 50134 Florence, Italy.

Published
2020

9. Correction to: Results from the European Union MAPEC_LIFE cohort study on air pollution and chromosomal damage in children: are public health policies sufficiently protective? (Environmental Sciences Europe, (2020), 32, 1, (74), 10.1186/s12302-020-00352-3)

Author

Ceretti, E., Donato, F., Zani, C., Villarini, M., Verani, M., De Donno, A., Bonetta, S., Feretti, D., Carducci, A., Idolo, A., Carraro, E., Covolo, L., Moretti, M., Palomba, G., Grassi, T., Bonetti, A., Bonizzoni, S., Biggeri, A., Gelatti, U., Festa, A., Viola, G. C. V., Zerbini, I., Fatigoni, C., Levorato, S., Monarca, S., Salvatori, T., Vannini, S., Donzelli, G., Bagordo, F., De Giorgi, M., Guido, M., Panico, A., Serio, F., Tumolo, M. R., Gea, M., Gilli, G., Pignata, C., Schiliro, T., Romanazzi, V., Furia, C., Bruni, B., and Casini, B.

Subjects
air pollution, chromosomal damage, public health policies, air pollution, public health policies, chromosomal damage
Published
2020

10. Methodological protocol for assessing the environmental footprint by means of ecotoxicological tools: wastewater treatment plants as an example case

Author

Pedrazzani, R, Baroni, P, Feretti, D, Mazzoleni, G, Steimberg, N, Urani, C, Viola, G, Zerbini, I, Ziliani, E, Bertanza, G, Pedrazzani, Roberta, Baroni, Pietro, Feretti, Donatella, Mazzoleni, Giovanna, Steimberg, Nathalie, Urani, Chiara, Viola, Gaia, Zerbini, Ilaria, Ziliani, Emanuele, Bertanza, Giorgio, Pedrazzani, R, Baroni, P, Feretti, D, Mazzoleni, G, Steimberg, N, Urani, C, Viola, G, Zerbini, I, Ziliani, E, Bertanza, G, Pedrazzani, Roberta, Baroni, Pietro, Feretti, Donatella, Mazzoleni, Giovanna, Steimberg, Nathalie, Urani, Chiara, Viola, Gaia, Zerbini, Ilaria, Ziliani, Emanuele, and Bertanza, Giorgio

Abstract

The ecotoxicological tools reveal to be profitably employable within the assessment of the so-called environmental footprint, which is commonly based on the results of a chemical monitoring. Due to the heterogeneity of biological endpoints and the possibility to explore several exposure frames, as well as to consider higher levels of organization (from cells to organisms and mesocosms), the definition of a protocol is desirable.

Published
2020

12. Monitoring air pollution effects on children for supporting public health policies (MAPEC_LIFE study)

Author

Ceretti, E, Donato, F, Feretti, D, Carducci, A, Moretti, M, Donno, A De, Carraro, E, Biggeri, A, and Gelatti, U

Subjects
Public Health, Environmental and Occupational Health
Abstract

Background Children are at high risk of suffering health consequences of air pollution and childhood exposure can increase the risk of developing chronic diseases in adulthood. The MAPEC_LIFE project, funded by EU Life+ Programme (LIFE12 ENV/IT/000614), aimed to evaluate the association between air pollution exposure and biomarkers of early effect in children and to propose guidance for implementing environmental policies. Methods The study was carried out on 6-8-year-old children. Micronucleus (MN) frequency was investigated in buccal cells of children and its association with air pollution exposure was assessed applying multiple Poisson regression mixed models, including socio-demographic and lifestyle factors as confounders. We also dichotomize air pollutants concentration according to the EU Ambient Air Quality Directives and WHO Air Quality Guidelines in all Poisson regression models to assess their risk predictive capacity. Results The project involved 1149 children providing buccal cells in winter and spring. 2139 biological samples were included in the analysis (1093 collected in winter, 1046 in spring). The analysis of the association between MN frequency and air quality parameters found positive associations for PM10, PM2.5, benzene, SO2 and ozone. Considering EU Directives, an association was found between MN frequency and PM10 exposure higher than the annual limit value, with an increase of the risk of 17.9% (95%CIs: 0.6-38.1%). Considering WHO Guidelines, the exposures to levels of PM10, benzene and BaP higher than the annual limits were associated with MN frequency, with a risk increase of 22.5%, 27.8% and 59.8% (95%CIs: 3.9-44.3%, 3.8-57.3%, 21.0-111.1%), respectively. Conclusions The analyses conducted showed an association between MN frequency in buccal cells of children and levels of some air pollutants, even at concentration below EU and WHO thresholds, which hence seemed to be insufficient for protecting children from this type of damage. Key messages Air pollution exposure induced chromosomal damage in buccal cells of children, even at concentration below the law limits. Early biological damage detected might be predictive of the occurrence of future harmful effects in humans, at a population level.

Published
2019

21. Micronucleus cytome assay in exfoliated buccal cells of children exposed to different level of air pollutants. The MAPEC_LIFE project

Author

Ceretti, E., Viola, G. C. V., Feretti, D., Levorato, S., Verani, M., Bagordo, F., Bonetta, Sa., Zerbini, I., Salvatori, T., Casini, B., De Donno, A., Pignata, C., Vannini, S., Bonizzoni, S., Gelatti, U. and the MAPEC_LIFE Study Group., Ceretti, E, Viola, Gcv, Feretti, D, Levorato, S, Verani, M, Bagordo, Francesco, Bonetta, Sa, Zerbini, I, Salvatori, T, Casini, B, DE DONNO, Maria Antonella, Pignata, C, Vannini, S, Bonizzoni, S, and Gelatti, U.

Published
2016

22. monitoring air pollution effects on children for supporting public health policy: the protocol of the prospective cohort MAPEC study

Author

Feretti, D., Ceretti, E., Moretti, M., Carducci, A., Bonetta, S., Marrese, M. R., Bonetti, A., Covolo, L., Villarini, M., Verani, M., Schilirò, T., Limina, R. M., Monarca, S., Casini, B., Carraro, E., Zani, C., Mazzoleni, G., Levaggi, R., Gelatti, U., Compiani, S., Donato, F., Festa, A., Viola, G. C. V., Zerbini, I., Idolo, A., Serio, F., Tumolo, M. R., Dominici, L., Fatigoni, C., Levorato, S., Peverini, M., Vannini, S., Bruni, B., Caponi, E., Donzelli, G., Gilli, G., Pignata, C., Bonizzoni, S., Furia, C., Braga, F., Codenotti, R., Colombi, P., Lini, D., Mario, E., DE DONNO, Maria Antonella, BAGORDO, Francesco, GRASSI, Tiziana, GUIDO, Marcello, VERRI, Tiziano, Feretti, D., Ceretti, E., DE DONNO, Maria Antonella, Moretti, M., Carducci, A., Bonetta, S., Marrese, M. R., Bonetti, A., Covolo, L., Bagordo, Francesco, Villarini, M., Verani, M., Schilirò, T., Limina, R. M., Grassi, Tiziana, Monarca, S., Casini, B., Carraro, E., Zani, C., Mazzoleni, G., Levaggi, R., Gelatti, U., Compiani, S., Donato, F., Festa, A., Viola, G. C. V., Zerbini, I., Guido, Marcello, Idolo, A., Serio, F., Tumolo, M. R., Verri, Tiziano, Dominici, L., Fatigoni, C., Levorato, S., Peverini, M., Vannini, S., Bruni, B., Caponi, E., Donzelli, G., Gilli, G., Pignata, C., Bonizzoni, S., Furia, C., Braga, F., Codenotti, R., Colombi, P., Lini, D., Mario, E., Feretti, D, Ceretti, E, Moretti, M, Carducci, A, Bonetta, S, Marrese, M. R, Bonetti, A, Covolo, L, Villarini, M, Verani, M, Schilirò, T, Limina, R. M, Monarca, S, Casini, B, Carraro, E, Zani, C, Mazzoleni, G, and Levaggi, R

Subjects
COMET ASSAY, air pollution, Air pollution, SALMONELLA MUTAGENICITY, environmental pollution, Public health, child health, Mutagenesis, mucosa buccal cell, medicine.disease_cause, MICRONUCLEUS FREQUENCY, Epidemiology, Environmental monitoring, Protocol, Prospective Studies, Child, ENVIRONMENTAL-POLLUTANTS, Health Policy, Absolute risk reduction, General Medicine, PERIPHERAL-BLOOD LYMPHOCYTES, Public Health, mucosa buccal cells, Human, Environmental Monitoring, medicine.medical_specialty, EUROPEAN COHORTS, AMBIENT AIR, DNA damage, PUBLIC HEALTH, children, early biological effect, Air Pollution, Humans, Medicine (all), Environmental health, medicine, EXPOSURE, Socioeconomic status, Health policy, Pollutant, GENETIC-DAMAGE, business.industry, IN-VITRO, Prospective Studie, business
Abstract

Introduction Genotoxic biomarkers have been studied largely in adult population, but few studies so far have investigated them in children exposed to air pollution. Children are a high-risk group as regards the health effects of air pollution and some studies suggest that early exposure during childhood can play an important role in the development of chronic diseases in adulthood. The objective of the project is to evaluate the associations between the concentration of urban air pollutants and biomarkers of early biological effect in children, and to propose a model for estimating the global risk of early biological effects due to air pollutants and other factors in children. Methods and analysis Two biomarkers of early biological effects, DNA damage by the comet assay and the micronuclei (MN) test, will be investigated in oral mucosa cells of 6–8-year-old children. Concurrently, some toxic airborne pollutants (polycyclic aromatic hydrocarbon (PAH) and nitro-PAH) and in vitro air mutagenicity and toxicity in ultra-fine air particulates (PM0.5) will be evaluated. Furthermore, demographic and socioeconomic variables, other sources of exposures to air pollutants and lifestyle variables will be assessed by a structured questionnaire. The associations between sociodemographic, environmental and other exposure variables and biomarkers of early biological effect using univariate and multivariate models will be analysed. A tentative model for calculating the global absolute risk of having early biological effects caused by air pollution and other variables will be proposed. Ethics and dissemination The project has been approved by the Ethics Committees of the local Health Authorities. The results will be communicated to local Public Health Agencies, for supporting educational programmes and health policy strategies. LIFE+2012 Environment Policy and Governance. LIFE12 ENV/IT/000614.

Published
2014

25. Mutagenicità di acque reflue

Author

Zani, C., Pedrazzani, R., Bertanza, G., Steimberg, N., Viola, G. V. C., Zerbini, I., Ceretti, E., and Feretti, D.

Published
2017

27. Feasibility and reliability of a questionnaire for evaluation of the exposure to indoor and outdoor air pollutants, diet and physical activity in 6-8-year-old children

Author

Zani, C, Donato, F, Grioni, S, Viola, G. C. V, Ceretti, E, Feretti, D, Festa, A, Bonizzoni, S, Bonetti, A, Monarca, S, Villarini, M, Levorato, S, Carducci, A, Verani, M, Casini, B, Carraro, E, Gilli, G, Bonetta, S, Gelatti, U, Covolo, L, Levaggi, R, Limina, RM, Mazzoleni, G, Zerbini, I, Furia, C, Marrese, MR, Colombi, P, Mario, E, Braga, F, Fatigoni, C, Moretti, M, Vannini, S, Bruni, B, Caponi, E, Donzelli, G, Tumolo, MR, Romanazzi, V, Pignata, C, Schilirò T., DE DONNO, Maria Antonella, GRASSI, Tiziana, IDOLO, ADELE, BAGORDO, Francesco, GUIDO, Marcello, DEVOTI, Gabriele, SERIO, FRANCESCA, Zani, C, Donato, F, Grioni, S, Viola, G. C. V, Ceretti, E, Feretti, D, Festa, A, Bonizzoni, S, Bonetti, A, Monarca, S, Villarini, M, Levorato, S, Carducci, A, Verani, M, Casini, B, DE DONNO, Maria Antonella, Grassi, Tiziana, Idolo, Adele, Carraro, E, Gilli, G, Bonetta, S, Gelatti, U, Covolo, L, Levaggi, R, Limina, Rm, Mazzoleni, G, Zerbini, I, Furia, C, Marrese, Mr, Colombi, P, Mario, E, Braga, F, Fatigoni, C, Moretti, M, Vannini, S, Bruni, B, Caponi, E, Donzelli, G, Bagordo, Francesco, Guido, Marcello, Devoti, Gabriele, Tumolo, Mr, Serio, Francesca, Romanazzi, V, Pignata, C, and Schilirò, T.

Subjects
Male, Reproducibility of Result, Environmental Exposure, Health Survey, Motor Activity, Reliability, Food-frequency questionnaire, Diet, Health Statu, Feasibility Studie, Italy, Parent, Air Pollution, Indoor, Surveys and Questionnaires, Female, Repeatability, Child, Children, Environmental Monitoring, Human
Abstract

The MAPEC-Life project aims to study the biological effects of early exposure to air pollutants on the oral mucosa cells of school-age children in five Italian cities. A questionnaire was created to evaluate the association between outdoor and indoor airborne pollutants, lifestyle, diet and biomarker effects. The feasibility and reliability of the questionnaire were evaluated.

Published
2015

30. Chemical analysis, mutagenicity and genotoxicity of PM0.5 collected in Perugia (Italy)

Author

Levorato, S, Ceretti, E, Bonetta, S, Salvatori, T, Feretti, D, Carraro, E, Vannini, S, Zerbini, I, Pignata, C, Carducci, A, Bagordo, F, Fatigoni, C, Bonizzoni, S, Bonetti, A, Villarini, M, and Gelatti, U.

Subjects
Ames test, comet test, micronucleus assay, PM0.5, toxicity, PM0.5, toxicity, Ames test, comet test, micronucleus assay
Published
2016

31. Exposure to air pollution and lifestyles of children partecipating in the MAPEC_LIFE (Monitoring Air Pollution Effects on Children for Supporting Public Health Policy) study

Author

Grassi, T, DONNO A, De, Bagordo, F, Ceretti, E, Zani, C, Moretti, M, Levorato, S, Carducci, A, Verani, M, Bonetta, S, Bonizzoni, S, Bonetti, A, Guido, M, Devoti, G, Gelatti, U, Bruni, B, Carraro, E, Casini, B, Codenotti, R, Colombi, T, Covolo, L, Crottini, S, De Giorgi, M, Donato, F, Donzelli, G, Fatigoni, C, Feretti, D, Festa, A, Furia, C, Gaffurini, L, Gilli, G, Idolo, A, Limina, Rm, Monarca, S, Pignata, C, Romanazzi, V, Salvatori, T, Schilirò, T, Serio, F, Vannini, S, Verri, T, Villarini, M, Viola, Gcv, Zagni, L, and Zerbini, I

Published
2016

33. Are 6-8 year old Italian children moving away from the Mediterranean diet?

Author

Zani, C., Ceretti, E., Grioni, S., Viola, G. C. V., Donato, F., Feretti, D., Festa, A., Bonizzoni, S., Bonetti, A., Monarca, S., Villarini, M., Levorato, S., Carducci, A., Verani, M., Casini, B., De Donno, A., Grassi, T., Idolo, A., Carraro, Elisabetta, Bonetta, Silvia, Bonetta, Sara, Gelatti, MAPEC LIFE Study Group, U., Romanazzi, Valeria, Pignata, Cristina, Schiliro', Tiziana, and Gilli, Giorgio

Subjects
Mediterranean diet, Food-frequency questionnaire, Mediterranean diet, Italian Mediterranean Index, Italian Mediterranean Index, Food-frequency questionnaire
Published
2016

35. The MAPEC_LIFE Study: indoor/outdoor air pollution exposure and lifestyles of the prospective cohort

Author

DONNO A, De, Bagordo, F, Zani, C, Ceretti, E, Villarini, M, Vannini, S, Carducci, A, Casini, B, Bonetta, S, Schilirò, T, Bonizzoni, S, Bonetti, A, Grassi, T, Guido, M, Devoti, G, Gelatti, U, Serio, F., Idolo, A., De Giorgi, M., Tumolo, M. R., Verri, T., Covolo, L., Donato, F., Feretti, D., Festa, A., Limina, R. M., Viola, G. C., Zerbini, I., Fatigoni, C., Levorato, S., Monarca, S., Moretti, M., Salvatori, T., Donzelli, G., Verani, M., Bruni, B., Bonetta, Si., Carraro, E., Gilli, G., Pignata, C., Romanazzi, V., Furia, C., Codenotti, R., Colombi, P., Crottini, S., Gaffurini, L., and Zagni, L.

Published
2016

37. Feasibility and reliability of a questionnaire for evaluation of the exposure to indoor and outdoor air pollutants, diet and physical activity in 6-8-year-old children

Author

Zani, C., Donato, F., Grioni, S., Viola, G. C. V., Ceretti, E., Feretti, D., Festa, A., Bonizzoni, S., Bonetti, A., Monarca, S., Villarini, M., Levorato, S., Carducci, A., Verani, M., Casini, B., De Donno, M. A., Grassi, T., Idolo, A., Carraro, Elisabetta, Gilli, Giorgio, Bonetta, Sara, Gelatti, MAPEC LIFE study Group, U., Bonetta, Silvia, Romanazzi, Valeria, Pignata, Cristina, and Schiliro', Tiziana

Subjects
Male, Parents, food-frequency questionnaire, repeatability, reliability, children, Health Status, Children, Food-frequency questionnaire, Reliability, Repeatability, Reproducibility of Results, Children, Food-frequency questionnaire, Reliability, Repeatability, Environmental Exposure, Motor Activity, Health Surveys, Diet, Italy, Air Pollution, Indoor, Surveys and Questionnaires, Feasibility Studies, Humans, Female, Child, Environmental Monitoring
Abstract

The MAPEC-Life project aims to study the biological effects of early exposure to air pollutants on the oral mucosa cells of school-age children in five Italian cities. A questionnaire was created to evaluate the association between outdoor and indoor airborne pollutants, lifestyle, diet and biomarker effects. The feasibility and reliability of the questionnaire were evaluated.A questionnaire was drawn up to be filled in by the parents of 6-8-year-old children. It consisted of 148 questions on the children's health, physical activity, environmental exposures and the frequency of food consumption at the main meals. First we conducted a questionnaire feasibility study involving 53 volunteer parents. We then performed a reliability study by administering the questionnaire to a further 156 parents and again one month later (test/retest method). The correlations between answers at the first and second administration of the questionnaire were evaluated using the Kappa statistic and Spearman's coefficient.After verifying the feasibility of the questionnaire, we conducted a reliability analysis on 132 completed questionnaires. The percentage of agreement between the first and the second responses given was over 70%, all K values being greater than 0.6. The analysis of calories and macronutrients also showed good agreement.The questionnaire drawn up for the study proved to be sufficiently reliable for gathering information about the factors of interest in our study of the relationship between air pollution and early biological effects in children.

Published
2015

40. The MAPEC_LIFE study (LIFE12 ENV/IT/000614): monitoring air pollution effects in children for supporting public health policy

Author

MARCO VERANI, annalaura carducci, BEATRICE CASINI, Marrese, M. R., Bonetti, A., Monarca, S., Donno, M. A., Carraro, E., Gelatti, U., Caponi, Elisa, Donzelli, Gabriele, Bruni, Beatrice, Ceretti, E., Covolo, L., Donato, F., Feretti, D., Festa, A., Limina, R. M., Viola, G. C. V., Zani, C., Zerbini, I., Levaggi, R., Mazzoleni, G., Bonizzoni, S., Furia, C., Codenotti, R., Colombi, P., Crottini, S., Mario, E., Dominici, L., Fatigoni, C., Levorato, S., Moretti, M., Vannini, S., Villarini, M., Bagordo, F., Grassi, T., Guido, M., and Idolo, A.

Published
2014

47. [Assessment of the genotoxic effects of gaseous emissions and percolates from three municipal landfills using plant bioassays]

Author

Feretti D, Elisabetta Ceretti, Zerbini I, Rm, Limina, Dominici L, Moretti M, Monarca S, and Donato F

Subjects
Chromosome Aberrations, Air Pollutants, Mutagenicity Tests, Meristem, Chromosomes, Plant, Refuse Disposal, Italy, Tradescantia, Onions, Humans, Soil Pollutants, Biological Assay, Environmental Pollutants, Cities, Environmental Monitoring, Mutagens
Abstract

The biomonitoring of genotoxic effects in environmental complex mixtures using higher plants is very useful for hazard evaluation. In this study we evaluated the potential application of plant genotoxicity tests in monitoring mutagens in landfill environment. The clastogenic effects of gaseous emissions (biogas)from three municipal landfills were evaluated by in situ monitoring using the Tradescantia micronucleus assay. The cytotoxicity and genotoxicity of leachates were studied using the Allium cepa test. We found no significant differences in micronuclei frequency in pollen cells of Tradescantia. Leachate samples showed elevated toxicity that inhibited root tip development in Allium cepa. Genotoxicity of the leachates was evaluated in diluted samples only. We found a significant increase in chromosomal metaphase aberrations only in one of the samples analyzed. In conclusion, biogas was not shown to be a real hazard, whereas leachates were found to display elevated toxicity. It would be advisable to treat leachates before releasing them into the environment as they can cause ecological damages. Since plant bioassays are very useful for the in situ monitoring of environmental genotoxins they are important for the prevention of environmental pollution resulting from the disposal of solid waste.

Published
2009

49. Genotossicità di clorito e clorato

Author

Feretti, D, Zerbini, I, Ceretti, E, Zani, C, Donato, F, Fatigoni, Cristina, Villarini, Milena, Moretti, Massimo, and Monarca, Silvano

Published
2009

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