Raquel Linares, Brigita Bax, Andreas Karwautz, Susana Jiménez-Murcia, Daniel Stein, Michiko Nakazato, Michael Zeiler, Violeta L. Moize, Lucero Munguía, Carlota Gudiol, Gema Frühbeck, Daniel Le Grange, Hana Papezova, Jue Chen, Laurence Claes, Katie Rowlands, Jéssica Sánchez-González, Teresa Rangil, Sara Bujalance-Arguijo, Sergey V. Popov, Jose Soriano-Pacheco, Mikhail F. Borisenkov, Mikel Etxandi, Jordi Carratalà, Ia Shekriladze, Maria Eulalia Loran Meler, Bea Pászthy, Gemma Mestre-Bach, Kate Tchanturia, Anders Håkansson, Fernando Fernández-Aranda, Ferenc Túry, Mar Carceller-Sindreu, Tetiana Ilnytska, Emilio Ortega, Nathalie Godart, Trevor Steward, Janet Treasure, Robert van Voren, Youl-Ri Kim, José Manuel Fernández-Real, Carlos Dieguez, Angela Favaro, Eduardo Serrano-Troncoso, Roser Granero, Francisco J. Tinahones, Isabel Sánchez, Koen Luyckx, Alba Andreu, Paulo P. P. Machado, Meritxell Lozano, Isabel Baenas, University Hospital of Bellvitge, CIBER Fisiopatología de la Obesidad y Nutrición ( (CIBEROBN)), Instituto de Salud Carlos III [Madrid] (ISC), University of Barcelona, Universidad Internacional de la Rioja (UNIR), University of Melbourne, Universitat Autònoma de Barcelona (UAB), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona (UB), Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Girona Biomedical Research Institute [Girona, Spain] (IDIBGI), Instituto de Investigación Biomédica de Málaga [Malaga, Espagne] (IBIMA), Universidad de Málaga [Málaga] = University of Málaga [Málaga], CIMUS Biomedical Research Institute [Santiago de Compostela], Clínica Universidad de Navarra [Pamplona], University of California [San Francisco] (UCSF), University of California, Institute of Psychiatry, Psychology & Neuroscience, King's College London, King‘s College London, Ilia State University [Tbilisi], Medizinische Universität Wien = Medical University of Vienna, University of Padua, KU Leuven (KU Leuven), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium, University of the Free State [South Africa], Institut de Recerca Pediàtrica Hospital Sant Joan de Déu [Barcelona, Spain], Germans Trias i Pujol University Hospital, Centro de Investigación Biomédica en Red Salud Mental [Madrid] (CIBER-SAM), Institut Català d'Oncologia--IDIBELL. L'Hospitalet de Llobregat, REIPI (Spanish Network for Research in Infectious Diseases), University of Minho [Braga], Lund University [Lund], Semmelweis University [Budapest], The Chaim Sheba Medical Center [Tel Hashomer, Israel], Vilnius University [Vilnius], Inje University, International University of Health and Welfare Hospital (IUHW Hospital), Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Institut Mutualiste de Montsouris (IMM), Vytautas Magnus University - Vytauto Didziojo Universitetas (VDU), Taras Shevchenko National University of Kyiv, School of Medicine [Shanghai Jiaotong University], Shanghai Jiaotong University, Ministerio de Economía y Competitividad, MINECO: PSI2015-68701-R Generalitat de Catalunya Generalitat de Catalunya Fundação para a Ciência e a Tecnologia, FCT: POCI-01-0145-FEDER-028145 European Regional Development Fund, FEDER Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas, CIBERDEM Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición, CIBEROBN Consejo Nacional de Ciencia y Tecnología, CONACYT Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM European Regional Development Fund, FEDER Instituto de Salud Carlos III, ISCIII: INT19/00046, PI17/01167, We thank CERCA Programme/Generalitat de Catalunya for institutional support. This manuscript and research was supported by grants from the Ministerio de Econom?a y Competitividad (PSI2015-68701-R), Instituto de Salud Carlos III (ISCIII) (INT19/00046 and PI17/01167) and co-funded by FEDER funds /European Regional Development Fund (ERDF), a way to build Europe. CIBERobn, CIBERsam and CIBERDEM are all initiatives of ISCIII. GMB is supported by a postdoctoral grant from FUNCIVA. This initiative is supported by Generalitat de Catalunya. LM is supported by a postdoctoral grant of the Mexican institution Consejo Nacional de Ciencia y Tecnolog?a (CONACYT). PPM was supported, in part, by a Portuguese Foundation for Science and Technology grant (POCI-01-0145-FEDER-028145). IB was partially supported by a Post-Residency Grant from Research Committee of the University Hospital of Bellvitge (HUB, Barcelona, Spain) 2019-2020. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript., and Universidade do Minho