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6. The fly route of extended-spectrum-β-lactamase-producing Enterobacteriaceae dissemination in a cattle farm: from the ecosystem to the molecular scale

Author

Caderhoussin, Alann, primary, Couvin, David, additional, Gruel, Gaëlle, additional, Quétel, Isaure, additional, Pot, Matthieu, additional, Arquet, Rémy, additional, Dereeper, Alexis, additional, Bambou, Jean-Christophe, additional, Talarmin, Antoine, additional, and Ferdinand, Séverine, additional

Published
2024
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10. Limited Transmission of Klebsiella pneumoniae among Humans, Animals, and the Environment in a Caribbean Island, Guadeloupe (French West Indies)

Author

Dereeper, Alexis, primary, Gruel, Gaëlle, additional, Pot, Matthieu, additional, Couvin, David, additional, Barbier, Elodie, additional, Bastian, Sylvaine, additional, Bambou, Jean-Christophe, additional, Gelu-Simeon, Moana, additional, Ferdinand, Séverine, additional, Guyomard-Rabenirina, Stéphanie, additional, Passet, Virginie, additional, Martino, Frederic, additional, Piveteau, Pascal, additional, Reynaud, Yann, additional, Rodrigues, Carla, additional, Roger, Pierre-Marie, additional, Roy, Xavier, additional, Talarmin, Antoine, additional, Tressieres, Benoit, additional, Valette, Marc, additional, Brisse, Sylvain, additional, and Breurec, Sébastien, additional

Published
2022
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11. Emergence of a Novel Lineage and Wide Spread of a blaCTX-M-15/IncHI2/ST1 Plasmid among Nosocomial Enterobacter in Guadeloupe

Author

Pot, Matthieu, primary, Reynaud, Yann, additional, Couvin, David, additional, Dereeper, Alexis, additional, Ferdinand, Séverine, additional, Bastian, Sylvaine, additional, Foucan, Tania, additional, Pommier, Jean-David, additional, Valette, Marc, additional, Talarmin, Antoine, additional, Guyomard-Rabenirina, Stéphanie, additional, and Breurec, Sébastien, additional

Published
2022
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12. KaruBioNet: a network and discussion group for a better collaboration and structuring of bioinformatics in Guadeloupe (French West Indies)

Author

Couvin, David, Dereeper, Alexis, Meyer, Damien F, Noroy, Christophe, Gaete, Stanie, Bhakkan, Bernard, Poullet, Nausicaa, Gaspard, Sarra, Bezault, Etienne, Marcelino, Isabel, Pruneau, Ludovic, Segretier, Wilfried, Stattner, Erick, Cazenave, Damien, Garnier, Maëlle, Pot, Matthieu, Tressières, Benoît, Deloumeaux, Jacqueline, Breurec, Sébastien, Ferdinand, Séverine, Gonzalez-rizzo, Silvina, Reynaud, Yann, Mulder, Nicola, Couvin, David, Dereeper, Alexis, Meyer, Damien F, Noroy, Christophe, Gaete, Stanie, Bhakkan, Bernard, Poullet, Nausicaa, Gaspard, Sarra, Bezault, Etienne, Marcelino, Isabel, Pruneau, Ludovic, Segretier, Wilfried, Stattner, Erick, Cazenave, Damien, Garnier, Maëlle, Pot, Matthieu, Tressières, Benoît, Deloumeaux, Jacqueline, Breurec, Sébastien, Ferdinand, Séverine, Gonzalez-rizzo, Silvina, Reynaud, Yann, and Mulder, Nicola

Abstract

Sequencing and other biological data are now more frequently available and at a lower price. Mutual tools and strategies are needed to analyze the huge amount of heterogeneous data generated by several research teams and devices. Bioinformatics represents a growing field in the scientific community globally. This multidisciplinary field provides a great amount of tools and methods that can be used to conduct scientific studies in a more strategic way. Coordinated actions and collaborations are needed to find more innovative and accurate methods for a better understanding of real-life data. A wide variety of organizations are contributing to KaruBioNet in Guadeloupe (French West Indies), a Caribbean archipelago. The purpose of this group is to foster collaboration and mutual aid among people from different disciplines using a ‘one health’ approach, for a better comprehension and surveillance of humans, plants or animals’ health and diseases. The KaruBioNet network particularly aims to help researchers in their studies related to ‘omics’ data, but also more general aspects concerning biological data analysis. This transdisciplinary network is a platform for discussion, sharing, training and support between scientists interested in bioinformatics and related fields. Starting from a little archipelago in the Caribbean, we envision to facilitate exchange between other Caribbean partners in the future, knowing that the Caribbean is a region with non-negligible biodiversity which should be preserved and protected. Joining forces with other Caribbean countries or territories would strengthen scientific collaborative impact in the region. Information related to this network can be found at: http://www.pasteur-guadeloupe.fr/karubionet.html. Furthermore, a dedicated ‘Galaxy KaruBioNet’ platform is available at: http://calamar.univ-ag.fr/c3i/galaxy_karubionet.html.

Published
2022
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13. High Prevalence of blaCTXM–1/IncI1-Iγ/ST3 Plasmids in Extended-Spectrum β-Lactamase-Producing Escherichia coli Isolates Collected From Domestic Animals in Guadeloupe (French West Indies)

Author

Gruel, Gaëlle, primary, Couvin, David, additional, Guyomard-Rabenirina, Stéphanie, additional, Arlet, Guillaume, additional, Bambou, Jean-Christophe, additional, Pot, Matthieu, additional, Roy, Xavier, additional, Talarmin, Antoine, additional, Tressieres, Benoit, additional, Ferdinand, Séverine, additional, and Breurec, Sébastien, additional

Published
2022
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14. KaruBioNet: a network and discussion group for a better collaboration and structuring of bioinformatics in Guadeloupe (French West Indies)

Author

Couvin, David, primary, Dereeper, Alexis, additional, Meyer, Damien F, additional, Noroy, Christophe, additional, Gaete, Stanie, additional, Bhakkan, Bernard, additional, Poullet, Nausicaa, additional, Gaspard, Sarra, additional, Bezault, Etienne, additional, Marcelino, Isabel, additional, Pruneau, Ludovic, additional, Segretier, Wilfried, additional, Stattner, Erick, additional, Cazenave, Damien, additional, Garnier, Maëlle, additional, Pot, Matthieu, additional, Tressières, Benoît, additional, Deloumeaux, Jacqueline, additional, Breurec, Sébastien, additional, Ferdinand, Séverine, additional, Gonzalez-Rizzo, Silvina, additional, and Reynaud, Yann, additional

Published
2022
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17. Wide Distribution and Specific Resistance Pattern to Third-Generation Cephalosporins of Enterobacter cloacae Complex Members in Humans and in the Environment in Guadeloupe (French West Indies)

Author

Pot, Matthieu, primary, Reynaud, Yann, additional, Couvin, David, additional, Ducat, Célia, additional, Ferdinand, Séverine, additional, Gravey, François, additional, Gruel, Gaëlle, additional, Guérin, François, additional, Malpote, Edith, additional, Breurec, Sébastien, additional, Talarmin, Antoine, additional, and Guyomard-Rabenirina, Stéphanie, additional

Published
2021
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18. Emergence of a Novel Lineage and Wide Spread of a bla CTX-M-15 /IncHI2/ST1 Plasmid among Nosocomial Enterobacter in Guadeloupe.

Author

Pot, Matthieu, Reynaud, Yann, Couvin, David, Dereeper, Alexis, Ferdinand, Séverine, Bastian, Sylvaine, Foucan, Tania, Pommier, Jean-David, Valette, Marc, Talarmin, Antoine, Guyomard-Rabenirina, Stéphanie, and Breurec, Sébastien

Subjects
ENTEROBACTER, ENTEROBACTER cloacae, ENTEROBACTERIACEAE diseases, KLEBSIELLA pneumoniae, NOSOCOMIAL infections, GENETIC variation, ACINETOBACTER infections
Abstract

Between April 2018 and August 2019, a total of 135 strains of Enterobacter cloacae complex (ECC) were randomly collected at the University Hospital Center of Guadeloupe to investigate the structure and diversity of the local bacterial population. These nosocomial isolates were initially identified genetically by the hsp60 typing method, which revealed the clinical relevance of E. xiangfangensis (n = 69). Overall, 57/94 of the third cephalosporin-resistant strains were characterized as extended-spectrum-β-lactamase (ESBL) producers, and their whole-genome was sequenced using Illumina technology to determine the clonal relatedness and diffusion of resistance genes. We found limited genetic diversity among sequence types (STs). ST114 (n = 13), ST1503 (n = 9), ST53 (n = 5) and ST113 (n = 4), which belong to three different Enterobacter species, were the most prevalent among the 57 ESBL producers. The blaCTXM-15 gene was the most prevalent ESBL determinant (56/57) and was in most cases associated with IncHI2/ST1 plasmid replicon carriage (36/57). To fully characterize this predominant blaCTXM-15/IncHI2/ST1 plasmid, four isolates from different lineages were also sequenced using Oxford Nanopore sequencing technology to generate long-reads. Hybrid sequence analyses confirmed the circulation of a well-conserved plasmid among ECC members. In addition, the novel ST1503 and its associated species (ECC taxon 4) were analyzed, in view of its high prevalence in nosocomial infections. These genetic observations confirmed the overall incidence of nosocomial ESBL Enterobacteriaceae infections acquired in this hospital during the study period, which was clearly higher in Guadeloupe (1.59/1000 hospitalization days) than in mainland France (0.52/1,000 hospitalization days). This project revealed issues and future challenges for the management and surveillance of nosocomial and multidrug-resistant Enterobacter in the Caribbean. [ABSTRACT FROM AUTHOR]

Published
2022
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19. Dissemination of Extended-Spectrum-β-Lactamase-Producing Enterobacter cloacae Complex from a Hospital to the Nearby Environment in Guadeloupe (French West Indies): ST114 Lineage Coding for a Successful IncHI2/ST1 Plasmid

Author

Pot, Matthieu, primary, Guyomard-Rabenirina, Stéphanie, additional, Couvin, David, additional, Ducat, Célia, additional, Enouf, Vincent, additional, Ferdinand, Séverine, additional, Gruel, Gaëlle, additional, Malpote, Edith, additional, Talarmin, Antoine, additional, Breurec, Sébastien, additional, and Reynaud, Yann, additional

Published
2021
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22. High Prevalence of bla CTXM –1/IncI1-Iγ/ST3 Plasmids in Extended-Spectrum β-Lactamase-Producing Escherichia coli Isolates Collected From Domestic Animals in Guadeloupe (French West Indies).

Author

Gruel, Gaëlle, Couvin, David, Guyomard-Rabenirina, Stéphanie, Arlet, Guillaume, Bambou, Jean-Christophe, Pot, Matthieu, Roy, Xavier, Talarmin, Antoine, Tressieres, Benoit, Ferdinand, Séverine, and Breurec, Sébastien

Subjects
DOMESTIC animals, ESCHERICHIA coli, PETS, FOOD animals, BACTERIAL genes, DRUG resistance in bacteria, PLASMIDS, PET care
Abstract

Extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) have been classified in the group of resistant bacteria of highest priority. We determined the prevalence of ESBL-E collected in feces from household and shelter pets in Guadeloupe (French West Indies). A single rectal swab was taken from 125 dogs and 60 cats between June and September 2019. The prevalence of fecal carriage of ESBL-E was 7.6% (14/185, 95% CI: 4.2-12.4), within the range observed worldwide. The only risk factor associated with a higher prevalence of ESBL-E rectal carriage was a stay in a shelter, suggesting that refuges could be hotspots for their acquisition. All but one (Klebsiella pneumoniae from a cat) were Escherichia coli. We noted the presence of a bla CTX–M –1/IncI1-Iγ/sequence type (ST3) plasmid in 11 ESBL-producing E. coli isolates belonging to ST328 (n = 6), ST155 (n = 4) and ST953 (n = 1). A bla CTX–M –15 gene was identified in the three remaining ESBL-E isolates. The bla CTX–M –1 and most of the antimicrobial resistance genes were present in a well-conserved large conjugative IncI1-Iγ/ST3 plasmid characterized by two accessory regions containing antibiotic resistance genes. The plasmid has been detected worldwide in E. coli isolates from humans and several animal species, such as food-producing animals, wild birds and pets, and from the environment. This study shows the potential role of pets as a reservoir of antimicrobial-resistant bacteria or genes for humans and underlines the importance of basic hygiene measures by owners of companion animals. [ABSTRACT FROM AUTHOR]

Published
2022
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23. Klebsiella pneumoniae from humans, animals and the environment in Guadeloupe: first insights into genomic

Author

Gruel, Gaelle, Pazzé, S., Guyomard-Rabenirina, Stéphanie, Ferdinand, Séverine, Bastian, S., Brisse, S., Malpote, Edith, Passet, Virginie, Antoine, Talarmin, Reynaud, Yann, Breurec, Sebastien, Institut Pasteur de la Guadeloupe, Réseau International des Instituts Pasteur (RIIP), Laboratoire de Microbiologie clinique et environnementale [Pointe-à-Pitre, Guadeloupe, France], CHU Pointe-à-Pitre/Abymes [Guadeloupe], Biodiversité et Epidémiologie des Bactéries pathogènes - Biodiversity and Epidemiology of Bacterial Pathogens, Institut Pasteur [Paris] (IP), Université des Antilles - UFR des sciences médicales Hyacinthe Bastaraud (UA UFR SM), Université des Antilles (UA), and Institut Pasteur [Paris]

Subjects
[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, [SDE.BE]Environmental Sciences/Biodiversity and Ecology
Abstract

International audience; K. pneumoniae (Kp) represents nearly 10% of nosocomial infections in the Western world, including Guadeloupe, and is one of the most problematic multidrug resistant bacteria. Hypervirulent clonal groups of Kp are also responsible for invasive community-acquired infections, such as pyogenic liver abscess and meningitis. As the reservoir of clinically and epidemiologically prominent clonal groups of Kp is currently unknown, we expect to define the sources of human infections through an “One Health” approach.

Published
2019

27. Antimicrobial use and resistance level in food-producing animals in Guadeloupe

Author

Gruel, Gaelle, Sellin, A., Riveiro, H., Breurec, Sebastien, Guyomard, Stéphanie, Antoine, Talarmin, Ferdinand, Séverine, Gros, Olivier, Bactériologie médicale et Environnementale, Institut Pasteur de Dakar, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Institut Pasteur de la Guadeloupe, and Réseau International des Instituts Pasteur (RIIP)

Subjects
[SDE.BE] Environmental Sciences/Biodiversity and Ecology, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, [SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, [SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2019

28. Reptiles in Guadeloupe (French West Indies) are a reservoir of major human Salmonella enterica serovars

Author

Guyomard-Rabenirina, Stéphanie, primary, Weill, François-Xavier, additional, Le Hello, Simon, additional, Bastian, Sylvaine, additional, Berger, Franck, additional, Ferdinand, Séverine, additional, Legreneur, Pierre, additional, Loraux, Cécile, additional, Malpote, Edith, additional, Muanza, Blandine, additional, Richard, Vincent, additional, Talarmin, Antoine, additional, and Breurec, Sébastien, additional

Published
2019
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30. Mycobacterium tuberculosis complex genetic diversity: mining the fourth international spoligotyping database (SpolDB4) for classification, population genetics and epidemiology

Author

Sajduda Anna, Rüsch-Gerdes Sabine, Rossetti M Lucia, Rasolonavalona Tiana, Rasolofo-Razanamparany Voahangy, Rahim Zeaur, Parwati Ida, Niemann Stefan, Naumann Ludmilla, Ngeow Yun, Narvskaïa Olga, Mokrousov Igor, Martin Christian, Martin Carlos, Ly Ho, Lillebaek Troels, Liens Benjamin, Kulkarni Savita P, Kubin Milan, Kremer Kristin, Kreiswirth Barry N, Kadival Gurujaj V, van Helden Paul D, Hawkey Peter M, Guttierez M Cristina, Gomes Harrison M, Gazzola Lidia, Garzelli Carlo, de Viedma Dario, Ferdinand Séverine, Fauville-Dufaux Maryse, Evans Jason T, Ellermeier Christopher, Diel Roland, Cataldi Angel, Cheong Soonfatt, Cafrune Patricia, Binder Lothar, Baumanis Viesturs, Arora Jyoti, Allix Caroline, Aristimuño Liselotte, Al-Hajoj Sahal A, Gori Andrea, Prodinger Wolfgang M, Rigouts Leen, Driscoll Jeffrey R, Brudey Karine, Samper Sofia, Shemyakin Igor G, Singh Urvashi B, Somoskovi Akos, Skuce Robin A, van Soolingen Dick, Streicher Elisabeth M, Suffys Philip N, Tortoli Enrico, Tracevska Tatjana, Vincent Véronique, Victor Tommie C, Warren Robin M, Yap Sook, Zaman Khadiza, Portaels Françoise, Rastogi Nalin, and Sola Christophe

Subjects
Microbiology, QR1-502
Abstract

Abstract Background The Direct Repeat locus of the Mycobacterium tuberculosis complex (MTC) is a member of the CRISPR (Clustered regularly interspaced short palindromic repeats) sequences family. Spoligotyping is the widely used PCR-based reverse-hybridization blotting technique that assays the genetic diversity of this locus and is useful both for clinical laboratory, molecular epidemiology, evolutionary and population genetics. It is easy, robust, cheap, and produces highly diverse portable numerical results, as the result of the combination of (1) Unique Events Polymorphism (UEP) (2) Insertion-Sequence-mediated genetic recombination. Genetic convergence, although rare, was also previously demonstrated. Three previous international spoligotype databases had partly revealed the global and local geographical structures of MTC bacilli populations, however, there was a need for the release of a new, more representative and extended, international spoligotyping database. Results The fourth international spoligotyping database, SpolDB4, describes 1939 shared-types (STs) representative of a total of 39,295 strains from 122 countries, which are tentatively classified into 62 clades/lineages using a mixed expert-based and bioinformatical approach. The SpolDB4 update adds 26 new potentially phylogeographically-specific MTC genotype families. It provides a clearer picture of the current MTC genomes diversity as well as on the relationships between the genetic attributes investigated (spoligotypes) and the infra-species classification and evolutionary history of the species. Indeed, an independent Naïve-Bayes mixture-model analysis has validated main of the previous supervised SpolDB3 classification results, confirming the usefulness of both supervised and unsupervised models as an approach to understand MTC population structure. Updated results on the epidemiological status of spoligotypes, as well as genetic prevalence maps on six main lineages are also shown. Our results suggests the existence of fine geographical genetic clines within MTC populations, that could mirror the passed and present Homo sapiens sapiens demographical and mycobacterial co-evolutionary history whose structure could be further reconstructed and modelled, thereby providing a large-scale conceptual framework of the global TB Epidemiologic Network. Conclusion Our results broaden the knowledge of the global phylogeography of the MTC complex. SpolDB4 should be a very useful tool to better define the identity of a given MTC clinical isolate, and to better analyze the links between its current spreading and previous evolutionary history. The building and mining of extended MTC polymorphic genetic databases is in progress.

Published
2006
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31. Retrospective assessment of pregnancy exposure to particulate matter from desert dust on a Caribbean island: could satellite-based aerosol optical thickness be used as an alternative to ground PM10 concentration?

Author

Tuffier, Stéphane, Upegui, Erika, Raghoumandan, Christina, Viel, Jean François, for the BrumiSaTerre research group, Ayhan, Gulen, Ferdinand, Séverine, Garbin, Céline, Guyomard, Stéphanie, Kadhel, Philippe, Mercier, Fabien, Michineau, Léah, Multigner, Luc, Quénel, Philippe, Raghoumandan, Christian, Talarmin, Antoine, and Viel, Jean-Francois

Subjects
DUST, AEROSOLS, PARTICULATE matter, PREGNANCY tests, PREGNANCY, PREMATURE labor
Abstract

Desert dust transported from the Saharan-Sahel region to the Caribbean Sea is responsible for peak exposures of particulate matter (PM). This study explored the potential added value of satellite aerosol optical thickness (AOT) measurements, compared to the PM concentration at ground level, to retrospectively assess exposure during pregnancy. MAIAC MODIS AOT retrievals in blue band (AOT470) were extracted for the French Guadeloupe archipelago. AOT470 values and PM10 concentrations were averaged over pregnancy for 906 women (2005–2008). Regression modeling was used to examine the AOT470-PM10 relationship during pregnancy and test the association between dust exposure estimates and preterm birth. Moderate agreement was shown between mean AOT470 retrievals and PM10 ground-based measurements during pregnancy (R2 = 0.289). The magnitude of the association between desert dust exposure and preterm birth tended to be lower using the satellite method compared to the monitor method. The latter remains an acceptable trade-off between epidemiological relevance and exposure misclassification, in areas with few monitoring stations and complex topographical/meteorological conditions, such as tropical islands. [ABSTRACT FROM AUTHOR]

Published
2021
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33. Differences of microparticle patterns between sickle cell anemia and hemoglobin SC patients

Author

Garnier, Yohann, Ferdinand, Séverine, Etienne-Julan, Maryse, Elana, Gisèle, Petras, Marie, Doumdo, Lydia, Tressières, Benoit, Lalanne-Mistrih, Marie-Laure, Hardy-Dessources, Marie-Dominique, Connes, Philippe, Romana, Marc, ROMANA, marc, Biologie Intégrée du Globule Rouge (BIGR (UMR_S_1134 / U1134)), Institut National de la Transfusion Sanguine [Paris] (INTS)-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles (UA), Observatoire Régional de la Santé de la Guadeloupe, Unité Transversale de la Drépanocytose, CHU Pointe-à-Pitre/Abymes [Guadeloupe], CHU Fort de France, Centre d'investigation clinique Antilles-Guyane (CIC - Antilles Guyane), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de la Martinique [Fort de France]-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Dynamique des Structures et Interactions des Macromolécules Biologiques - Pôle de La Réunion (DSIMB Réunion), Institut National de la Transfusion Sanguine [Paris] (INTS)-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles (UA)-Institut National de la Transfusion Sanguine [Paris] (INTS)-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles (UA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles (UA)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Université de La Réunion (UR)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Transfusion Sanguine [Paris] (INTS), Laboratory of Excellence GR-Ex 'The red cell: from genesis to death', PRES Sorbonne Paris Cité, CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Hôpital Ricou, Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU de la Martinique [Fort de France]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM), Université des Antilles et de la Guyane (UAG), Hôpital Ricou-CHU Pointe-à-Pitre/Abymes [Guadeloupe], Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])

Subjects
Male, [SDV.MHEP.HEM] Life Sciences [q-bio]/Human health and pathology/Hematology, Erythrocytes, Physiology, [SDV]Life Sciences [q-bio], lcsh:Medicine, Biochemistry, Epithelium, Families, Spectrum Analysis Techniques, Animal Cells, Cell-Derived Microparticles, Medicine and Health Sciences, Child, lcsh:Science, Children, ComputingMilieux_MISCELLANEOUS, [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology, Hematology, Flow Cytometry, Body Fluids, Blood, Genetic Diseases, Spectrophotometry, Female, Cytophotometry, Anatomy, Cellular Types, Research Article, Platelets, Blood Platelets, congenital, hereditary, and neonatal diseases and abnormalities, Adolescent, Anemia, Sickle Cell, Phosphatidylserines, Research and Analysis Methods, Blood Plasma, Autosomal Recessive Diseases, Humans, Hemoglobin, Clinical Genetics, Sickle Cell Disease, Blood Cells, lcsh:R, Biology and Life Sciences, Proteins, Endothelial Cells, Epithelial Cells, Cell Biology, Hemoglobinopathies, Biological Tissue, Age Groups, People and Places, Population Groupings, lcsh:Q, Hemoglobin SC Disease
Abstract

International audience; Sickle cell anemia (SCA) and hemoglobin SC (HbSC) disease are the two most common forms of sickle cell disease (SCD), a frequent hemoglobinopathy which exhibits a highly variable clinical course. Although high levels of microparticles (MPs) have been consistently reported in SCA and evidence of their harmful impact on the SCA complication occurrences have been provided, no data on MP pattern in HbSC patients has been reported so far. In this study, we determined and compared the MP patterns of 84 HbSC and 96 SCA children, all at steady-state, using flow cytometry. Most of circulating MPs were derived from platelets (PLTs) and red blood cells (RBCs) in the two SCD syndromes. Moreover, we showed that HbSC patients exhibited lower blood concentration of total MPs compared to SCA patients, resulting mainly from a decrease of MP levels originated from RBCs and to a lesser extent from PLTs. We did not detect any association between blood MP concentrations and the occurrence of painful vaso-occlusive crises, acute chest syndrome and pulmonary hyper-tension in both patient groups. We also demonstrated for the first time, that whatever the considered genotype, RBC-derived MPs exhibited higher externalized phosphatidylserine level and were larger than PLT-derived MPs.

Published
2017
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37. Dissemination of Extended-Spectrum-β-Lactamase-Producing Enterobacter cloacaeComplex from a Hospital to the Nearby Environment in Guadeloupe (French West Indies): ST114 Lineage Coding for a Successful IncHI2/ST1 Plasmid

Author

Pot, Matthieu, Guyomard-Rabenirina, Stéphanie, Couvin, David, Ducat, Célia, Enouf, Vincent, Ferdinand, Séverine, Gruel, Gae¨lle, Malpote, Edith, Talarmin, Antoine, Breurec, Sébastien, and Reynaud, Yann

Abstract

Wastewater treatment plants are considered hot spots for antibiotic resistance. Most studies have addressed the impact on the aquatic environment, as water is an important source of anthropogenic pollutants.

Published
2021
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38. Measuring workload with electrodermal activity during common braking actions

Author

Messonnier, Laurent A., Chatel, Benjamin, Messonnier, Laurent, Barge, Quentin, Vilmen, Christophe, Noirez, Philippe, Bernard, Monique, Pialoux, Vincent, Bendahan, David, Brudey, Laura, Cita, Kizzy-Clara, Brureau, Laurent, Lemonne, Nathalie, Billaud, Marie, Connes, Philippe, Ferdinand, Séverine, Tressieres, Benoit, Tarer, Vanessa, Etienne-Julan, Maryse, Blanchet, Pascal, Elion, Jacques, Romana, Marc, Lam, Wilbur, Collet, C., Salvia, E., Petit-Boulanger, C., Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Laboratory of Exercise Physiology, University of Savoie, Chambery, and University Jean Monnet of Saint-Etienne, Saint-Etienne, Laboratory of Exercise Physiology, Institut national du sport, de l'expertise et de la performance (INSEP), Laboratoire de Physiologie-Biologie du Sport, Université d'Auvergne - Clermont-Ferrand I (UdA), Observatoire Régional de la Santé de la Guadeloupe, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Unité Transversale de la Drépanocytose [Pointe-à-Pitre, Guadeloupe], CHU Pointe-à-Pitre/Abymes [Guadeloupe], Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] (CRCTB), Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Centre d'investigation clinique Antilles-Guyane (CIC - Antilles Guyane), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de la Martinique [Fort de France]-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Service de Neurologie [CHU Pointe à Pitre], Insern, UMR 763, Hôpital Robert Debré, Université Paris Diderot - Paris 7 (UPD7), Pharmacogénétique et abords thérapeutiques des maladies héréditaires, Université des Antilles et de la Guyane (UAG)-Université Paris Diderot - Paris 7 (UPD7)-IFR2-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Lariboisière, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU de la Martinique [Fort de France]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Lariboisière-Université Paris Diderot - Paris 7 (UPD7), Laboratoire de Physiologie de l'Exercice (LPE), Université Jean Monnet - Saint-Étienne (UJM), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])

Subjects
Adult, medicine.medical_specialty, Automobile Driving, [SDV]Life Sciences [q-bio], Physical Therapy, Sports Therapy and Rehabilitation, Human Factors and Ergonomics, Workload, Galvanic Skin Response, Audiology, Middle Aged, Young Adult, Mental condition, Electrodermal response, medicine, Humans, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Mental load, Emergencies, Skin conductance, Psychology, Simulation, Stress, Psychological, ComputingMilieux_MISCELLANEOUS
Abstract

How to assess mental load remains a recurrent question. We aimed to explore whether slight differences in real-world driving task demands could be discriminated by electrodermal response (EDR). A sample of 33 participants was observed under five conditions: controlled braking from 50 to 30 km/h, 80 to 50 km/h, 50 to 0 km/h, 80 to 0 km/h, and a single unexpected emergency braking event from 80 to 0 km/h. The likelihood of EDR and, whenever present, its duration were both correlated with workload as represented by the deceleration demand. A higher base travel speed and the unexpected demand of the emergency braking situation impacted EDR, thus attesting higher workload level. EDR explains why stopping the vehicle from 50 km/h and slowing down from 80 to 50 km/h was of similar strain. The results further demonstrate that EDR measures can be successfully employed to discriminate multiple levels of workload.Common braking elicited different loads as revealed by electrodermal response (EDR) with sensitivity to deceleration of - 0.2 g. Even the slightest braking elicited a strain measurable with EDR. Accordingly, EDR may objectively assess the resulting strain during driving, with enhanced reliability if associated with other variables, e.g. cardiac activity.

Published
2014
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39. Effect of Age on Blood Rheology in Sickle Cell Anaemia and Sickle Cell Haemoglobin C Disease: A Cross-Sectional Study

Author

Renoux, Céline, primary, Romana, Marc, additional, Joly, Philippe, additional, Ferdinand, Séverine, additional, Faes, Camille, additional, Lemonne, Nathalie, additional, Skinner, Sarah, additional, Garnier, Nathalie, additional, Etienne-Julan, Maryse, additional, Bertrand, Yves, additional, Petras, Marie, additional, Cannas, Giovanna, additional, Divialle-Doumdo, Lydia, additional, Nader, Elie, additional, Cuzzubbo, Daniela, additional, Lamarre, Yann, additional, Gauthier, Alexandra, additional, Waltz, Xavier, additional, Kebaili, Kamila, additional, Martin, Cyril, additional, Hot, Arnaud, additional, Hardy-Dessources, Marie-Dominique, additional, Pialoux, Vincent, additional, and Connes, Philippe, additional

Published
2016
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40. Men with Sickle Cell Anemia and Priapism Exhibit Increased Hemolytic Rate, Decreased Red Blood Cell Deformability and Increased Red Blood Cell Aggregate Strength

Author

Cita, Kizzy-Clara, primary, Brureau, Laurent, additional, Lemonne, Nathalie, additional, Billaud, Marie, additional, Connes, Philippe, additional, Ferdinand, Séverine, additional, Tressières, Benoit, additional, Tarer, Vanessa, additional, Etienne-Julan, Maryse, additional, Blanchet, Pascal, additional, Elion, Jacques, additional, and Romana, Marc, additional

Published
2016
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46. Mycobacterium tuberculosis complex genetic diversity:Mining the fourth international spoligotyping database (SpolDB4) for classification, population genetics and epidemiology

Author

Brudey, Karine, Driscoll, Jeffrey R., Rigouts, Leen, Prodinger, Wolfgang M., Gori, Andrea, Al-Hajoj, Sahal A., Allix, Caroline, Aristimuño, Liselotte, Arora, Jyoti, Baumanis, Viesturs, Binder, Lothar, Cafrune, Patricia, Cataldi, Angel, Cheong, Soonfatt, Diel, Roland, Ellermeier, Christopher, Evans, Jason T., Fauville-Dufaux, Maryse, Ferdinand, Séverine, De Viedma, Dario Garcia, Garzelli, Carlo, Gazzola, Lidia, Gomes, Harrison M., Guttierez, M. Cristina, Hawkey, Peter M., Van Helden, Paul D., Kadival, Gurujaj V., Kreiswirth, Barry N., Kremer, Kristin, Kubin, Milan, Kulkarni, Savita P., Liens, Benjamin, Lillebaek, Troels, Ho, Minh Ly, Martin, Carlos, Martin, Christian, Mokrousov, Igor, Narvskaïa, Olga, Yun, Fong Ngeow, Naumann, Ludmilla, Niemann, Stefan, Parwati, Ida, Rahim, Zeaur, Rasolofo-Razanamparany, Voahangy, Rasolonavalona, Tiana, Rossetti, M. Lucia, Rüsch-Gerdes, Sabine, Sajduda, Anna, Samper, Sofia, Shemyakin, Igor G., Brudey, Karine, Driscoll, Jeffrey R., Rigouts, Leen, Prodinger, Wolfgang M., Gori, Andrea, Al-Hajoj, Sahal A., Allix, Caroline, Aristimuño, Liselotte, Arora, Jyoti, Baumanis, Viesturs, Binder, Lothar, Cafrune, Patricia, Cataldi, Angel, Cheong, Soonfatt, Diel, Roland, Ellermeier, Christopher, Evans, Jason T., Fauville-Dufaux, Maryse, Ferdinand, Séverine, De Viedma, Dario Garcia, Garzelli, Carlo, Gazzola, Lidia, Gomes, Harrison M., Guttierez, M. Cristina, Hawkey, Peter M., Van Helden, Paul D., Kadival, Gurujaj V., Kreiswirth, Barry N., Kremer, Kristin, Kubin, Milan, Kulkarni, Savita P., Liens, Benjamin, Lillebaek, Troels, Ho, Minh Ly, Martin, Carlos, Martin, Christian, Mokrousov, Igor, Narvskaïa, Olga, Yun, Fong Ngeow, Naumann, Ludmilla, Niemann, Stefan, Parwati, Ida, Rahim, Zeaur, Rasolofo-Razanamparany, Voahangy, Rasolonavalona, Tiana, Rossetti, M. Lucia, Rüsch-Gerdes, Sabine, Sajduda, Anna, Samper, Sofia, and Shemyakin, Igor G.

Abstract

Background: The Direct Repeat locus of the Mycobacterium tuberculosis complex (MTC) is a member of the CRISPR (Clustered regularly interspaced short palindromic repeats) sequences family. Spoligotyping is the widely used PCR-based reverse-hybridization blotting technique that assays the genetic diversity of this locus and is useful both for clinical laboratory, molecular epidemiology, evolutionary and population genetics. It is easy, robust, cheap, and produces highly diverse portable numerical results, as the result of the combination of (1) Unique Events Polymorphism (UEP) (2) Insertion-Sequence- mediated genetic recombination. Genetic convergence, although rare, was also previously demonstrated. Three previous international spoligotype databases had partly revealed the global and local geographical structures of MTC bacilli populations, however, there was a need for the release of a new, more representative and extended, international spoligotyping database. Results: The fourth international spoligotyping database, SpolDB4, describes 1939 shared-types (STs) representative of a total of 39,295 strains from 122 countries, which are tentatively classified into 62 clades/lineages using a mixed expert-based and bioinformatical approach. The SpolDB4 update adds 26 new potentially phylogeographically-specific MTC genotype families. It provides a clearer picture of the current MTC genomes diversity as well as on the relationships between the genetic attributes investigated (spoligotypes) and the infra-species classification and evolutionary history of the species. Indeed, an independent Naïve-Bayes mixture-model analysis has validated main of the previous supervised SpolDB3 classification results, confirming the usefulness of both supervised and unsupervised models as an approach to understand MTC population structure. Updated results on the epidemiological status of spoligotypes, as well as genetic prevalence maps on six main lineages are also shown. Our results sugg

Published
2006

47. Decrease of externalized phosphatidylserine density on red blood cell‐derived microparticles in SCA patients treated with hydroxycarbamide.

Author

Garnier, Yohann, Ferdinand, Séverine, Connes, Philippe, Garnier, Marie, Etienne‐Julan, Maryse, Lemonne, Nathalie, and Romana, Marc

Subjects
*SICKLE cell anemia, *HYDROXYUREA, *PHOSPHATIDYLSERINES, *PROTEIN C, *ERYTHROCYTES, *PATIENTS, *THERAPEUTICS
Abstract

The article presents a study which aims at comparing the microparticles (MP) pattern in a group of sickle cell anaemia (SCA) patients treated by hydroxycarbamide (HC). It states that HC treatment on MP concentration in SCA patients. It mentions that decrease of Phosphatidylserine (PS) externalization could be associated with the normalization of protein C level observed in SCA HC‐treated patients as red blood cells (RBC)-derived MPs have been associated with consumption of activated protein.

Published
2018
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49. Mycobacterium tuberculosis complex genetic diversity: mining the fourth international spoligotyping database (SpolDB4) for classification, population genetics and epidemiology

Author

Brudey, Karine, primary, Driscoll, Jeffrey R, additional, Rigouts, Leen, additional, Prodinger, Wolfgang M, additional, Gori, Andrea, additional, Al-Hajoj, Sahal A, additional, Allix, Caroline, additional, Aristimuño, Liselotte, additional, Arora, Jyoti, additional, Baumanis, Viesturs, additional, Binder, Lothar, additional, Cafrune, Patricia, additional, Cataldi, Angel, additional, Cheong, Soonfatt, additional, Diel, Roland, additional, Ellermeier, Christopher, additional, Evans, Jason T, additional, Fauville-Dufaux, Maryse, additional, Ferdinand, Séverine, additional, de Viedma, Dario Garcia, additional, Garzelli, Carlo, additional, Gazzola, Lidia, additional, Gomes, Harrison M, additional, Guttierez, M Cristina, additional, Hawkey, Peter M, additional, van Helden, Paul D, additional, Kadival, Gurujaj V, additional, Kreiswirth, Barry N, additional, Kremer, Kristin, additional, Kubin, Milan, additional, Kulkarni, Savita P, additional, Liens, Benjamin, additional, Lillebaek, Troels, additional, Ly, Ho Minh, additional, Martin, Carlos, additional, Martin, Christian, additional, Mokrousov, Igor, additional, Narvskaïa, Olga, additional, Ngeow, Yun Fong, additional, Naumann, Ludmilla, additional, Niemann, Stefan, additional, Parwati, Ida, additional, Rahim, Zeaur, additional, Rasolofo-Razanamparany, Voahangy, additional, Rasolonavalona, Tiana, additional, Rossetti, M Lucia, additional, Rüsch-Gerdes, Sabine, additional, Sajduda, Anna, additional, Samper, Sofia, additional, Shemyakin, Igor G, additional, Singh, Urvashi B, additional, Somoskovi, Akos, additional, Skuce, Robin A, additional, van Soolingen, Dick, additional, Streicher, Elisabeth M, additional, Suffys, Philip N, additional, Tortoli, Enrico, additional, Tracevska, Tatjana, additional, Vincent, Véronique, additional, Victor, Tommie C, additional, Warren, Robin M, additional, Yap, Sook Fan, additional, Zaman, Khadiza, additional, Portaels, Françoise, additional, Rastogi, Nalin, additional, and Sola, Christophe, additional

Published
2006
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