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146 results on '"Fenoy, Albert J."'

26. Surgical Management for Dystonia: Efficacy of Deep Brain Stimulation in the Long Term

Author

Kamel, Walaa A., Majumdar, Pritam, Matis, Georgios, Fenoy, Albert J., Balakrishnan, Shankar, Zirh, Ali T., Cevik, Aslihan, Tomar, Amit Kumar, Ouerchefani, Naoufel, Kamel, Walaa A., Majumdar, Pritam, Matis, Georgios, Fenoy, Albert J., Balakrishnan, Shankar, Zirh, Ali T., Cevik, Aslihan, Tomar, Amit Kumar, and Ouerchefani, Naoufel

Abstract

Introduction: Dystonia is a movement disorder substantially affecting the quality of life. Botulinum Neurotoxin (BoNT) is used intramuscularly as a treatment for dystonia; however, not all dystonia patients respond to this treatment. Deep brain stimulation (DBS) is an established treatment for Parkinson's disease (PD) and essential tremor, but it can help in dystonia as well. Objectives: We studied a total of 67 dystonia patients who were treated with DBS over a period of 7 years to find out the long-term efficacy of DBS in those patients. First, we calculated patient improvement in post-surgery follow-up programs using the Global Dystonia Severity scale (GDS) and Burke-Fahn-Marsden dystonia rating scale (BFMDRS). Secondly, we analyzed the scales scores to see if there was any statistical significance. Methods: In our study we analyzed patients with ages from 38 to 78 years with dystonia who underwent DBS surgery between January 2014 and December 2020 in four different centers (India, Kuwait, Egypt, and Turkey). The motor response to DBS surgery was retrospectively measured for each patient during every follow-up visit using the GDS and the BFMDRS scales. Results: Five to 7 years post-DBS, the mean reduction in the GDS score was 30 +/- 1.0 and for the BFMDRS score 26 +/- 1.0. The longitudinal change in scores at 12 and 24 months post-op was also significant with mean reductions in GDS and BFMDRS scores of 68 +/- 1.0 and 56 +/- 1.0, respectively. The p-values were <0.05 for our post-DBS dystonia patients. Conclusions: This study illustrates DBS is an established, effective treatment option for patients with different dystonias, such as generalized, cervical, and various brain pathology-induced dystonias. Although symptoms are not completely eliminated, continuous improvements are noticed throughout the post-stimulation time frame.

Published
2021

31. Contributors

Author

Aarabi, Bizhan, primary, Ahn, Jaimo, additional, Ain, Michael C., additional, Alexander, Lawrence, additional, An, Howard S., additional, Anderson, Paul A., additional, Apfelbaum, Ronald I., additional, Asghar, Jahangir, additional, Barrett, Matthew Owen, additional, Basra, Sushil, additional, Bhargava, Amit, additional, Bell, Randy, additional, Bellabarba, Carlo, additional, Bessey, Jason T., additional, Betz, Randal R., additional, Biyani, Ashok, additional, Blake, Brian J., additional, Bono, Christopher M., additional, Brockmeyer, Douglas, additional, Brodke, Darrel S., additional, Brothers, Justin G., additional, Buchowski, Jacob M., additional, Carmouche, Jonathan, additional, Carter, Kawanaa D., additional, Chaichana, Kaisorn L., additional, Chang, Jae-Chil, additional, Chapman, Jens R., additional, Chi, John H., additional, Chin, Kingsley R., additional, Chou, Dean, additional, Christie, Sean D., additional, Chu, Gordon K.T., additional, Cunningham, Mary, additional, Canto, Richard A. Dal, additional, DePass, Keisha, additional, Deutsch, Harel, additional, Dvorak, Marcel F., additional, Elgafy, Hossein, additional, Erulkar, Jonathan S., additional, Farhadi, H. Francis, additional, Fassett, Daniel, additional, Fehlings, Michael G., additional, Fenoy, Albert J., additional, Ferguson, Bryan, additional, Finn, Michael A., additional, France, John C., additional, Freedman, Brett A., additional, Gabos, Peter G., additional, Gaines, Robert W., additional, Garfin, Steven, additional, Gelb, Daniel E., additional, Gibula, Douglas Robert, additional, Gorman, Peter H., additional, Grauer, Jonathan N., additional, Harris, Mitchel B., additional, Heary, Robert F., additional, Hecht, Andrew C., additional, Hurlbert, R. John, additional, Iguchi, Mark, additional, Johnson, Bryce A., additional, Johnson, J. Patrick, additional, Kelly, Dori, additional, Khanna, A. Jay, additional, Kim, Choll, additional, Kim, Daniel H., additional, Kim, David H., additional, Kim, Kee D., additional, Kim, Se-Hoon, additional, Kim, Terrence T., additional, Klimo, Paul, additional, Kuklo, Timothy R., additional, Kumar, Sanjeev, additional, Lawrence, James P., additional, Levi, Allan D., additional, Louis-Ugbo, John, additional, Ludwig, Steven C., additional, Manzano, Glen, additional, Mathur, Sameer, additional, McCall, Todd, additional, McCutcheon, Ian E., additional, Mehta, Samir, additional, Mendel, Ehud, additional, Menezes, Arnold H., additional, Molinari, Robert W., additional, Mummaneni, Praveen, additional, Nathan, David J., additional, Newton, Peter O., additional, Ondra, Stephen L., additional, O'Shaughnessy, Brian, additional, Pait, T. Glenn, additional, Park, Jongsoo, additional, Patel, Rakesh, additional, Perry, Andrew, additional, Phillips, Frank M., additional, Poelstra, Kornelis A., additional, Pryor, John D., additional, Quinnan, Stephan M., additional, Qureshi, Sheeraz, additional, Rampersaud, Y. Raja, additional, Randolph, Gannon B., additional, Rao, Ganesh, additional, Riesenburger, Ron I., additional, Reiter, Mitchell F., additional, Resnick, Daniel K., additional, Roberto, Rolando F., additional, Routt, M.L. “Chip”, additional, Rustamzadeh, Edward, additional, Salas, Virginia M., additional, Samartzis, Dino, additional, Samdani, Amer, additional, Schildhauer, Thomas A., additional, Schkrohowsky, Joshua G., additional, Schmidt, Meic H., additional, Scioscia, Thomas N., additional, Scuderi, Gaetano, additional, Sebastian, Cyril T., additional, Segal, Lee S., additional, Sethi, Rajiv K., additional, Shah, Suken A., additional, Sheth, Rishi N., additional, Siddique, Khawar, additional, Singh, Kern, additional, Sponseller, Paul D., additional, Steinmetz, Michael P., additional, Stevens, David, additional, Traynelis, Vincent C., additional, Tredway, Trent L., additional, Tribus, Clifford B., additional, Truumees, Eeric, additional, Vaccaro, Alexander R., additional, VanderHave, Kelly L., additional, Vibert, Brady T., additional, Vincent, Frederick, additional, Walker, Matthew H., additional, Wallach, David M., additional, Walsh, Brian, additional, Wang, Jeffrey C., additional, White, Andrew P., additional, Wood, Kirkham B., additional, Yeon, Howard B., additional, Yoon, S. Tim, additional, and Youssef, Jim A., additional

Published
2008
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34. Deep Brain Stimulation of the Pedunculopontine Nucleus Area in Parkinson Disease

Author

Goetz, Laurent, primary, Bhattacharjee, Manik, additional, Ferraye, Murielle U, additional, Fraix, Valérie, additional, Maineri, Carina, additional, Nosko, Daniela, additional, Fenoy, Albert J, additional, Piallat, Brigitte, additional, Torres, Napoléon, additional, Krainik, Alexandre, additional, Seigneuret, Eric, additional, David, Olivier, additional, Parent, Martin, additional, Parent, André, additional, Pollak, Pierre, additional, Benabid, Alim -Louis, additional, Debu, Bettina, additional, and Chabardès, Stéphan, additional

Published
2019
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35. Medial Forebrain Bundle Deep Brain Stimulation Reverses Anhedonic-Like Behavior in a Chronic Model of Depression: Importance of BDNF and Inflammatory Cytokines

Author

Dandekar, Manoj P., primary, Saxena, Ashwini, additional, Scaini, Giselli, additional, Shin, Joo Hyun, additional, Migut, Agata, additional, Giridharan, Vijayasree Vayalanellore, additional, Zhou, Yuzhi, additional, Barichello, Tatiana, additional, Soares, Jair C., additional, Quevedo, Joao, additional, and Fenoy, Albert J., additional

Published
2018
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45. Low Cerebral Glucose Metabolism: A Potential Predictor for the Severity of Vascular Parkinsonism and Parkinson's Disease.

Author

Yunqi Xu, Xiaobo Wei, Xu Liu, Jinchi Liao, Jiaping Lin, Cansheng Zhu, Xiaochun Xiaochun, Dongsi Xie, Dongman Chao, Fenoy, Albert J., Muhua Cheng, Beisha Tang, Zhuohua Zhang, Ying Xia, and Qing Wang

Subjects
GLUCOSE, PARKINSONIAN disorders, PARKINSON'S disease
Abstract

This study explored the association between cerebral metabolic rates of glucose (CMRGlc) and the severity of Vascular Parkinsonism (VP) and Parkinson's disease (PD). A cross-sectional study was performed to compare CMRGlc in normal subjects vs. VP and PD patients. Twelve normal subjects, 22 VP, and 11 PD patients were evaluated with the H&Y and MMSE, and underwent 18F-FDG measurements. Pearson's correlations were used to identify potential associations between the severity of VP/PD and CMRGlc. A pronounced reduction of CMRGlc in the frontal lobe and caudate putamen was detected in patients with VP and PD when compared with normal subjects. The VP patients displayed a slight CMRGlc decrease in the caudate putamen and frontal lobe in comparison with PD patients. These decreases in CMRGlc in the frontal lobe and caudate putamen were significantly correlated with the VP patients' H&Y, UPDRS II, UPDRS III, MMSE, cardiovascular, and attention/memory scores. Similarly, significant correlations were observed in patients with PD. This is the first clinical study finding strong evidence for an association between low cerebral glucose metabolism and the severity of VP and PD. Our findings suggest that these changes in glucose metabolism in the frontal lobe and caudate putamen may underlie the pathophysiological mechanisms of VP and PD. As the scramble to find imaging biomarkers or predictors of the disease intensifies, a better understanding of the roles of cerebral glucose metabolism may give us insight into the pathogenesis of VP and PD. [ABSTRACT FROM AUTHOR]

Published
2015
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46. Primary bone tumors of the spine in children

Author

Fenoy, Albert J., primary, Greenlee, Jeremy D. W., additional, Menezes, Arnold H., additional, Donovan, Kathleen A., additional, Sato, Yutaka, additional, Hitchon, Patrick W., additional, and Chaloupka, John C., additional

Published
2006
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48. Contributors

Author

Aarabi, Bizhan, Ahn, Jaimo, Ain, Michael C., Alexander, Lawrence, An, Howard S., Anderson, Paul A., Apfelbaum, Ronald I., Asghar, Jahangir, Barrett, Matthew Owen, Basra, Sushil, Bhargava, Amit, Bell, Randy, Bellabarba, Carlo, Bessey, Jason T., Betz, Randal R., Biyani, Ashok, Blake, Brian J., Bono, Christopher M., Brockmeyer, Douglas, Brodke, Darrel S., Brothers, Justin G., Buchowski, Jacob M., Carmouche, Jonathan, Carter, Kawanaa D., Chaichana, Kaisorn L., Chang, Jae-Chil, Chapman, Jens R., Chi, John H., Chin, Kingsley R., Chou, Dean, Christie, Sean D., Chu, Gordon K.T., Cunningham, Mary, Canto, Richard A. Dal, DePass, Keisha, Deutsch, Harel, Dvorak, Marcel F., Elgafy, Hossein, Erulkar, Jonathan S., Farhadi, H. Francis, Fassett, Daniel, Fehlings, Michael G., Fenoy, Albert J., Ferguson, Bryan, Finn, Michael A., France, John C., Freedman, Brett A., Gabos, Peter G., Gaines, Robert W., Jr., Garfin, Steven, Gelb, Daniel E., Gibula, Douglas Robert, Gorman, Peter H., Grauer, Jonathan N., Harris, Mitchel B., Heary, Robert F., Hecht, Andrew C., Hurlbert, R. John, Iguchi, Mark, Johnson, Bryce A., Johnson, J. Patrick, Kelly, Dori, Khanna, A. Jay, Kim, Choll, Kim, Daniel H., Kim, David H., Kim, Kee D., Kim, Se-Hoon, Kim, Terrence T., Klimo, Paul, Jr., Kuklo, Timothy R., Kumar, Sanjeev, Lawrence, James P., Levi, Allan D., Louis-Ugbo, John, Ludwig, Steven C., Manzano, Glen, Mathur, Sameer, McCall, Todd, McCutcheon, Ian E., Mehta, Samir, Mendel, Ehud, Menezes, Arnold H., Molinari, Robert W., Mummaneni, Praveen, Nathan, David J., Newton, Peter O., Ondra, Stephen L., O'Shaughnessy, Brian, Pait, T. Glenn, Park, Jongsoo, Patel, Rakesh, Perry, Andrew, Phillips, Frank M., Poelstra, Kornelis A., Pryor, John D., Quinnan, Stephan M., Qureshi, Sheeraz, Rampersaud, Y. Raja, Randolph, Gannon B., Rao, Ganesh, Riesenburger, Ron I., Reiter, Mitchell F., Resnick, Daniel K., Roberto, Rolando F., Routt, M.L. “Chip”, Rustamzadeh, Edward, Salas, Virginia M., Samartzis, Dino, Samdani, Amer, Schildhauer, Thomas A., Schkrohowsky, Joshua G., Schmidt, Meic H., Scioscia, Thomas N., Scuderi, Gaetano, Sebastian, Cyril T., Segal, Lee S., Sethi, Rajiv K., Shah, Suken A., Sheth, Rishi N., Siddique, Khawar, Singh, Kern, Sponseller, Paul D., Steinmetz, Michael P., Stevens, David, Traynelis, Vincent C., Tredway, Trent L., Tribus, Clifford B., Truumees, Eeric, Vaccaro, Alexander R., VanderHave, Kelly L., Vibert, Brady T., Vincent, Frederick, Walker, Matthew H., Wallach, David M., Walsh, Brian, Wang, Jeffrey C., White, Andrew P., Wood, Kirkham B., Yeon, Howard B., Yoon, S. Tim, and Youssef, Jim A.

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49. A narrative review on invasive brain stimulation for treatment-resistant depression.

Author

Dandekar MP, Diaz AP, Rahman Z, Silva RH, Nahas Z, Aaronson S, Selvaraj S, Fenoy AJ, Sanches M, Soares JC, Riva-Posse P, and Quevedo J

Subjects
Brain, Depression, Humans, Psychotherapy, Deep Brain Stimulation methods, Depressive Disorder, Treatment-Resistant therapy
Abstract

While most patients with depression respond to pharmacotherapy and psychotherapy, about one-third will present treatment resistance to these interventions. For patients with treatment-resistant depression (TRD), invasive neurostimulation therapies such as vagus nerve stimulation, deep brain stimulation, and epidural cortical stimulation may be considered. We performed a narrative review of the published literature to identify papers discussing clinical studies with invasive neurostimulation therapies for TRD. After a database search and title and abstract screening, relevant English-language articles were analyzed. Vagus nerve stimulation, approved by the U.S. Food and Drug Administration as a TRD treatment, may take several months to show therapeutic benefits, and the average response rate varies from 15.2-83%. Deep brain stimulation studies have shown encouraging results, including rapid response rates (> 30%), despite conflicting findings from randomized controlled trials. Several brain regions, such as the subcallosal-cingulate gyrus, nucleus accumbens, ventral capsule/ventral striatum, anterior limb of the internal capsule, medial-forebrain bundle, lateral habenula, inferior-thalamic peduncle, and the bed-nucleus of the stria terminalis have been identified as key targets for TRD management. Epidural cortical stimulation, an invasive intervention with few reported cases, showed positive results (40-60% response), although more extensive trials are needed to confirm its potential in patients with TRD.

Published
2022
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