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7 results on '"Feng-I Chu"'

2. Solid-state NMR studies of the molecular structure of Taxol

Author

Yu Ho, Feng-I Chu, and Der-Lii M. Tzou

Subjects
Carbon Isotopes, Magnetic Resonance Spectroscopy, Molecular Structure, Paclitaxel, Stereochemistry, Chemistry, Molecular Conformation, Resonance, General Chemistry, Structural difference, Ring (chemistry), Antineoplastic Agents, Phytogenic, Molecular conformation, Crystallography, Solid-state nuclear magnetic resonance, Magic angle spinning, Molecule, General Materials Science, Spectroscopy
Abstract

Solid-state 13C{1H} cross-polarization/magic angle spinning spectroscopy (CP/MAS) has been utilized to extract the molecular structure information of Taxol, which is an anti-tumor therapeutic medicine extracted from the yew bark. The 13C signals have chemical shift values quite consistent with those measured in solution phase, and the overall chemical shift range is over 200 ppm. Notably, most of the 13C resonances of the taxane ring have two clearly resolved spectral components except the resonance peaks of C-15, C-16 and C-17, which are located at the central part of the taxane ring. On the basis of our NMR data, we propose that these doublets originate from two slightly different molecular conformations of the taxane ring and still the central part of the ring remains structurally similar. Furthermore, it is demonstrated that the 13C chemical shift difference deduced from the doublet splittings can serve as a direct measure of the structural difference between the two conformations, which could possibly correlate with the anti-tumor activity of Taxol. Copyright © 2006 John Wiley & Sons, Ltd.

Published
2006

3. 1H, 13C and 15N resonance assignments for proapoptotic protein Nix (residue 1∼156) from Danio rerio

Author

Chang-Jen Huang, Feng-I Chu, Der-Lii M. Tzou, and Yu Ho

Subjects
biology, Chemistry, Danio, Resonance, biology.organism_classification, Biochemistry, Structure and function, law.invention, Crystallography, Residue (chemistry), Structural Biology, law, Apoptosis, Recombinant DNA, biological phenomena, cell phenomena, and immunity, Zebrafish, Mitochondrial protein
Abstract

Nix protein is a BH3-only pro-apoptotic mitochondrial protein. Here we reported the 1H, 13C and 15N resonance assignments of zebrafish Nix protein for further understanding the structure and function relationship.

Published
2007

4. Cyber-physical handshake

Author

Yu-Chee Tseng, Feng-I Chu, and Fang-Jing Wu

Subjects
Authentication, Ubiquitous computing, Participatory sensing, Handshake, Social network, Computer Networks and Communications, Computer science, business.industry, Cyber-physical system, Computer security, computer.software_genre, Handshaking, Sensing data, business, Personally identifiable information, Wireless sensor network, computer, Software
Abstract

While sensor-enabled devices have greatly enriched human interactions in our daily life, discovering the essential knowledge behind sensing data is a critical issue to connect the cyber world and the physical world. This motivates us to design an innovative sensor-aided social network system, termed cyber-physical handshake. It allows two users to naturally exchange personal information with each other after detecting and authenticating the handshaking patterns between them. This work describes our design of detection and authentication mechanisms to achieve this purpose and our prototype system to facilitate handshake social behavior.

Published
2011

5. NMR assignment of the vaccinia virus envelope protein A27L

Author

Yu Ho, Der-Lii M. Tzou, and Feng-I Chu

Subjects
Magnetic Resonance Spectroscopy, Protein Conformation, Chemistry, Stereochemistry, Heparitin Sulfate, Vaccinia virus, Nuclear magnetic resonance spectroscopy, Biochemistry, Virology, Viral Proteins, chemistry.chemical_compound, Protein structure, Viral envelope, Vaccinia, Spectroscopy
Published
2005

6. Service-Oriented Architecture Application in Long-Term Care Institution: A Case Study on an Information System Project Based on the Whole Person Concept in Taiwan

Author

Feng-I Chung and Chia Lun Lo

Subjects
long-term care institutions, service oriented architecture, long-term care information management system, cross-referencing, anomalous incidents, Computer engineering. Computer hardware, TK7885-7895, Information technology, T58.5-58.64, Science, Electronic computers. Computer science, QA75.5-76.95
Abstract

Purpose–The caring approach for long-term care is different with the general care because it emphasizes comprehensive health care. If the system establishment lacks integrated concepts, the system will then be unsuitable. This study aims to develop an innovative system project based on the whole person concept and provides the experience for applying the concept of Service-Oriented Architecture (SOA) to integrate different operations of the system which called U-care project. Method–This involves substituting the function module of the original system architecture with a service-based approach to provide a service interface. In addition, there must be a connection between the well-defined interface for the services and the formation of comprehensively integrated system architecture. Evaluations were conducted both on the programmers of the U-care project and on end user experience form using the system.Results–The results describe our resulting functional design of the system. The implanted experience based on SOA was also presented and the services were success practice in a long term care institution. Conclusion–The contribution of this paper is the project functional design and practical feasibility. It also showed the SOA platform with a set of reusable domain function service is suitable for the long term care institution. It can support the actual improvement on the project development schedule and operational performance of personnel.Recommendations–Further work on emphasizing the establishment of domain knowledge by developers when developing long-term care related software to reduce difficulties in communication with users, refining the process applied to the SOA is recommended to improve the efficiency of the project. Research Implications–Service-oriented computing promotes the approach of assembling application components into a network of services that can be loosely coupled to create flexible, dynamic business processes and agile applications. Therefore, the architecture of service oriented uses services to support development teams can achieve rapid, low cost, interoperable, evolvable and massively distributed long term care system.

Published
2017
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