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3 results on '"Feng Chen Ifrim"'

1. Ld/Mm+ Simulation of Some Aristolochic and Humic Acids Species Coupled in Periodic Box with Water

Author

Alina-Maria Petrescu, Feng Chen Ifrim, Gheorghe Ilia, Virgil Paunescu, and Mihai V. Putz

Subjects
Models, Molecular, chemistry.chemical_classification, Molecular model, Analytical chemistry, Water, General Medicine, Molecular Docking Simulation, chemistry, Volume (thermodynamics), Drug Discovery, Molecular Medicine, Humic acid, Molecule, Computer Simulation, Total energy, Langevin dynamics, Humic Substances, PubChem
Abstract

Background: This study is one of the dynamics molecular docking that presents the interactions between a molecular model of the mixture of humic acid structure and 18 aristolochic acids structures, from PubChem database in a water box that simulates the environment reactions. Objective: The major objective was to identify what happens in this procedure(LD/MM+) with the coupled species. Method: LD/MM+ SIMULATION ( Langevin dynamics simulation) Results: The R-Squared statistic indicates that the model as fitted by MLR , explains 90.9437% of the variability in Volume. Conclusion: The interactions of these acids, the types of forces, and the way that these molecules can get closer to each other, in terms of total energy density, while identifying the specificities vis-à-vis of wateraromaticity or water-reactivity behaviors.

Published
2021

2. Cannabidiol—from Plant to Human Body: A Promising Bioactive Molecule with Multi-Target Effects in Cancer

Author

Zorita Diaconeasa, Ioana Zinuca Pavel, Cristina Dehelean, Diana Antal, Codruta Soica, Feng Chen Ifrim, Virgil Paunescu, Florina Ardelean, Brigitta Kis, Stefana Avram, Valentina Buda, and Corina Danciu

Subjects
Antineoplastic Agents, Review, Biology, Cannabis sativa, Catalysis, Brain cancer, Inorganic Chemistry, cannabidiol, Multi target, breast cancer, glioma, Neoplasms, medicine, melanoma, Humans, Physical and Theoretical Chemistry, Molecular Biology, Spectroscopy, Cannabis, brain cancer, pharmacological and toxicological profile, Traditional medicine, Plant Extracts, Organic Chemistry, Cancer, General Medicine, medicine.disease, prostate cancer, Prognosis, digestive system diseases, Computer Science Applications, lung cancer, clinical evidence, colon cancer, immunomodulatory effects, Clinical evidence, Cannabidiol, medicine.drug, Phytotherapy
Abstract

Cannabis sativa L. is a plant long used for its textile fibers, seed oil, and oleoresin with medicinal and psychoactive properties. It is the main source of phytocannabinoids, with over 100 compounds detected so far. In recent years, a lot of attention has been given to the main phytochemicals present in Cannabis sativa L., namely, cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC). Compared to THC, CBD has non-psychoactive effects, an advantage for clinical applications of anti-tumor benefits. The review is designed to provide an update regarding the multi-target effects of CBD in different types of cancer. The main focus is on the latest in vitro and in vivo studies that present data regarding the anti-proliferative, pro-apoptotic, cytotoxic, anti-invasive, anti-antiangiogenic, anti-inflammatory, and immunomodulatory properties of CBD together with their mechanisms of action. The latest clinical evidence of the anticancer effects of CBD is also outlined. Moreover, the main aspects of the pharmacological and toxicological profiles are given.

Published
2019

3. CHEMOMETRICS STUDY OF GERMS PLANT FOR DETERMINING ANTICANCER ACTIVITY.

Author

Petrescu, Alina-Maria, Zbîrcea, Lauriana-Eunice, Buzan, Maria-Roxana, Jucos, Gianina-Loredana, Feng Chen Ifrim, Ilia, Gheorghe, and Paunescu, Virgil

Subjects
*PLANT germplasm, *TRANSGENIC plants, *ANTIOXIDANTS, *GERMINATION, *PLANT embryology
Abstract

This project started from the premise that in nature, there are substances capable of preventing the occurrence of cancer, or, at least keeping it in its early stages, by using plant germs. Germs were obtained from Biovita germs machine, like: watercress, unshelled and genetically modified soybeans, hyssop, sage, fennel, amaranth, broccoli, radish, alfalfa, cumin, caraway, rye, wheat, buckwheat, and the next step was to extract the substances from these germs, and analyzed by LS/MS, for the identification of polyphenolic compounds, which are antioxidants, which play a very important role in the prevention of cancer, mainly alphalinolenic acid, the main source of omega 3 fatty acids, essential for the human body. The process was carried out in several stages, namely: the germination period was 4-5 days, followed by maceration in hydroalcoholic solution with 99% ethyl alcohol, then the decoction and percolation in the system provided with separating funnel, filter and Erlenmayer glass. The antioxidant activity was determined using spectrophotometry (Tecan SunriseM - A Reliable Absorbance Reader), using as a calibration sample, ascorbic acid, the absorbance of which was already known from the literature data, namely 600 nm. The presence of riboflavin, at an absorbance of 440 nm, allantoin, 517 nm, quercetin, at an absorbance of 385 nm, choline, at 570 nm, and thiamine at an absorbance of 520 nm, was identified. The calibration curve was obtained based on the values of the concentrations used and the absorbance obtained. The scavering was determined, on the basis of which the antioxidant activity was identified. [ABSTRACT FROM AUTHOR]

Published
2020

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