Search

Your search keyword '"Feng, Yiwen"' showing total 45 results
Start Over Author "Feng, Yiwen"
45 results on '"Feng, Yiwen"'

6. Tracing the unspeakable : painting as embodied seeing

Author

Feng, Yiwen

Subjects
750
Abstract

My PhD research Tracing the Unspeakable: Painting as Embodied Seeing originates from the dramatic incident of my mother’s imprisonment and my state of disorientation caused by it. The event becomes a story that I live out and turns into imagined experiences that I gain access to through drawing and painting. I attempt to take possession of the event and its psychological effects on me through my art practice. By continuously enacting mother’s narrative and negotiating my relationship with it, I explore how artmaking can impart meaning to an ongoing life event and furthermore, make possible the forming and empowerment of oneself. This research involves studio-based investigations alongside a written report. Throughout the research, painting is employed as a methodology for exploring life experiences. In painting, I search for a language to represent the reality of my mother’s event and other events of entrapment, marginalisation and displacement. I examine how the absent and the unspeakable can be embodied in painting; how painting can open gaps for emotional and meaningful engagements in unsettled events; and whether painting is able to represent phenomena that are putatively unrepresentable. In the written report, I reflect on my studio practice in relation to my changing relationship with mother’s narrative and my use of it to make work. I investigate the competence of painting in representing memory, events and atrocity by examining the discourse of history painting and other relevant artistic practices. I also present an analytical account of my research in phenomenology and psychoanalysis on notions of perception, emotion, embodiment, body image, trauma and the self. Derived from the personal and moving into a wider social context, this research aims to seek new representations of existence in times of great political and cultural changes, and to offer new ways of engaging experiences of the other through embodied seeing in painting.

Published
2020

9. A Discussion of the Long-term Implementation of the 'Double Reduction' Policy Dilemma and its Countermeasures

Author

Feng, Yiwen, Striełkowski, Wadim, Editor-in-Chief, Black, Jessica M., Series Editor, Butterfield, Stephen A., Series Editor, Chang, Chi-Cheng, Series Editor, Cheng, Jiuqing, Series Editor, Dumanig, Francisco Perlas, Series Editor, Al-Mabuk, Radhi, Series Editor, Scheper-Hughes, Nancy, Series Editor, Urban, Mathias, Series Editor, Webb, Stephen, Series Editor, Holl, Augustin, editor, Chen, Jun, editor, and Guan, Guiyun, editor

Published
2022
Full Text
View/download PDF

17. Nature-inspired micro/nanomotors

Author

Dekai Zhou, Feng Yiwen, Longqiu Li, Bin Guo, and Xiaocong Chang

Subjects
Preparation method, Materials science, Animals, Humans, Nanotechnology, General Materials Science, Swarm behavior, Nature inspired
Abstract

Living things in nature have evolved with unique morphologies, structures, materials, behaviors, and functions to survive in complex natural environments. Nature has inspired the design ideas, preparation methods, and applications of versatile micro/nanomotors. This review summarizes diverse nature-inspired micro/nanomotors, which can be divided into five groups: (i) natural morphology-inspired micro/nanomotors, whose shapes are designed to imitate the morphologies of plants, animals, and objects in nature. (ii) Natural structure-inspired micro/nanomotors, which use structures from plants, red blood cells, and platelet cells as components of micro/nanomotors, or directly use sperm cells and microorganisms as the engines of micro/nanomotors. (iii) Natural behavior-inspired micro/nanomotors, which are proposed to mimic natural behaviors such as motion behavior, swarm behavior, and communication behavior between individuals. (iv) Micro/nanomotors inspired by both natural morphology and behavior. Nature makes it possible for synthetic micro/nanomotors to possess interesting morphologies, novel preparation methods, new propulsion modes, innovative functions, and broad applications. The nature-inspired micro/nanomotors could provide a promising platform for various practical fields.

Published
2022

18. Inhibition of integrated stress response protects against lipid-induced senescence in hypothalamic neural stem cells in adamantinomatous craniopharyngioma

Author

Wang, Chaohu, primary, Zhang, Huarong, additional, Fan, Jun, additional, Li, Qing, additional, Guo, Rongrong, additional, Pan, Jun, additional, Liu, Yawei, additional, Peng, Junxiang, additional, Zhu, Qianchao, additional, Feng, Yiwen, additional, Wu, Chengdong, additional, Luo, Peng, additional, Qiu, Xiaoyu, additional, Shi, Jin, additional, Deng, Yingying, additional, Qi, Songtao, additional, and Liu, Yi, additional

Published
2022
Full Text
View/download PDF

27. Downregulation of miR-145-5p in cancer cells and their derived exosomes may contribute to the development of ovarian cancer by targeting CT

Author

Feng Yiwen, Zhenyu Sang, Ya-Ping Zhu, Wenzhao Hang, Xiaowei Xi, Ye Yang, and Qian Huang

Subjects
0301 basic medicine, Carcinogenesis, Down-Regulation, Kaplan-Meier Estimate, exosomes, Biology, 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, microRNA, Genetics, Humans, Gene Regulatory Networks, Hippo signaling pathway, Ovarian Neoplasms, Oncogene, Microarray analysis techniques, Gene Expression Profiling, microRNA-145-5p, Connective Tissue Growth Factor, General Medicine, Articles, Cell cycle, Middle Aged, Prognosis, CTGF, Gene Expression Regulation, Neoplastic, MicroRNAs, 030104 developmental biology, ovarian cancer, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, Female, Toxicogenomics
Abstract

The present study aimed to identify shared microRNAs (miRNAs) in ovarian cancer (OC) cells and their exosomes using microarray data (accession number GSE103708) available from the Gene Expression Omnibus database, including exosomal samples from 13 OC cell lines and 3 normal ovarian surface epithelial cell lines, and their original cell samples. Differentially expressed miRNAs (DE‑miRNAs) were identified using the Linear Models for Microarray data method, and mRNA targets of DE‑miRNAs were predicted using the miRWalk2 database. The potential functions of target genes were analyzed using Database for Annotation, Visualization and Integrated Discovery and intersected with known OC‑associated pathways downloaded from the Comparative Toxicogenomics Database. The associations between crucial miRNAs and target genes, and their clinical associations, were validated using data from The Cancer Genome Atlas. As a result, 16 upregulated and 6 downregulated DE‑miRNAs were shared in OC cell lines and their exosomes compared with normal controls. The target genes of 11 common DE‑miRNAs were predicted. Among these DE‑miRNAs, a low expression of homo sapiens (hsa)‑miR‑145‑5p was significantly correlated with a poor prognosis and higher stages. Although 91 target genes were predicted for hsa‑miR‑145‑5p, only 4 genes [connective tissue growth factor (CTGF), myotubularin‑related protein 14, protein phosphatase 3 catalytic subunit alpha and suppressor of cytokine signaling 7] were suggested as risk factors for prognosis. The subsequent Pearson's correlation analysis validated a significant negative correlation between hsa‑miR‑145‑5p and CTGF (r=‑0.1126, P=0.02188). According to the results of the functional analysis, CTGF is involved in the Hippo signaling pathway (hsa04390). In conclusion, decreased expression of hsa‑miR‑145 in OC and OC‑derived exosomes may be a crucial biomarker for the diagnosis and treatment of OC.

Published
2018

40. Coexisting Cooperative Cognitive Micro‐/Nanorobots.

Author

Chang, Xiaocong, Tang, Wentian, Feng, Yiwen, Yu, Hao, Wu, Zhiguang, Xu, Tailin, Dong, Huijuan, and Li, Tianlong

Subjects
TARGETED drug delivery, ENVIRONMENTAL remediation, ECOSYSTEMS, COOPERATIVENESS, ZERO-valent iron
Abstract

Interaction behaviors are a crucial, distinctive feature of organisms in ecological systems. Inspired by nature, micro‐/nanorobots also show interaction behaviors with a significant number of novel and advanced functionalities. The micro‐/nanoscale size and self‐driven abilities of micro‐/nanorobots have attracted considerable attention for potential applications. The mission of micro‐/nanorobots has evolved from basic mechanical transfer or assistance to a diverse range of complex tasks, such as targeted drug delivery, biosensing, and environmental remediation. Herein, we focus on the interaction behavior of coexisting cooperative cognitive (Tri‐Co) micro‐/nanorobots, summarize recent research, and classify the interactions into three broad types: with the environment, with robot peers, and with human external control. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

43. Mechanistic modelling of relative biological effectiveness of carbon ion beams and comparison with experiments.

Author

Feng H, Li W, Zhang Y, Chang C, Hua L, Feng Y, Lai Y, and Geng L

Subjects
Relative Biological Effectiveness, DNA Damage, Ions, Monte Carlo Method, Carbon therapeutic use, Heavy Ion Radiotherapy
Abstract

Objective. Relative biological effectiveness (RBE) plays a vital role in carbon ion radiotherapy, which is a promising treatment method for reducing toxic effects on normal tissues and improving treatment efficacy. It is important to have an effective and precise way of obtaining RBE values to support clinical decisions. A method of calculating RBE from a mechanistic perspective is reported. Approach. Ratio of dose to obtain the same number of double strand breaks (DSBs) between different radiation types was used to evaluate RBE. Package gMicroMC was used to simulate DSB yields. The DSB inductions were then analyzed to calculate RBE. The RBE values were compared with experimental results. Main results. Furusawa's experiment yielded RBE values of 1.27, 2.22, 3.00 and 3.37 for carbon ion beam with dose-averaged LET of 30.3 keV μ m -1 , 54.5 keV μ m -1 , 88 keV μ m -1 and 137 keV μ m -1 , respectively. RBE values computed from gMicroMC simulations were 1.75, 2.22, 2.87 and 2.97. When it came to a more sophisticated carbon ion beam with 6 cm spread-out Bragg peak, RBE values were 1.61, 1.63, 2.19 and 2.36 for proximal, middle, distal and distal end part, respectively. Values simulated by gMicroMC were 1.50, 1.87, 2.19 and 2.34. The simulated results were in reasonable agreement with the experimental data. Significance. As a mechanistic way for the evaluation of RBE for carbon ion radiotherapy by combining the macroscopic simulation of energy spectrum and microscopic simulation of DNA damages, this work provides a promising tool for RBE calculation supporting clinical applications such as treatment planning., (© 2024 Institute of Physics and Engineering in Medicine.)

Published
2024
Full Text
View/download PDF

44. Tumor-selective Blockade of CD47 Signaling with CD47 Antibody for Enhanced Anti-tumor Activity in Malignant Meningioma.

Author

Liu X, Zhang H, Wang C, Li Z, Zhu Q, Feng Y, Fan J, Qi S, Wu Z, and Liu Y

Subjects
Humans, Antibodies, Cell Line, Tumor, Macrophages metabolism, Meningeal Neoplasms drug therapy, Meningeal Neoplasms metabolism, Meningeal Neoplasms pathology, Meningioma drug therapy, Meningioma metabolism, Meningioma pathology
Abstract

Background: Patients with WHO grade III meningioma have a poor prognosis with a median survival of less than two years and a high risk of recurrence. However, traditional treatment options have failed to improve prognosis. Therefore, development of novel immunotherapy targets is urgently needed. CD47 acting as a "don't eat me" signal to macrophages can trigger tumor immune escape. However, the role of CD47 in malignant meningioma is not well understood., Methods: We collected 190 clinical meningioma samples and detected the expression of CD47 and immune infiltration in WHO grade I-III by immunohistochemistry, western blot, qPCR. We also examined the functional effects of anti-CD47 on cell proliferation, migration and invasion, macrophagemediated phagocytosis and tumorigenicity both in vitro and in vivo ., Results: We found that the expression of CD47 was increased in malignant meningioma along with a decreased number of T cells and an increase in CD68 + macrophages. Blocking CD47 with anti-CD47 antibody (B6H12) suppressed tumor cell growth, motility and promoted macrophage-mediated phagocytosis in IOMM-Lee cells in vitro . In vivo experiments showed that anti-CD47 antibody (B6H12 or MIAP301) significantly inhibited the tumor growth and this effect was partly blocked by the depletion of macrophages. Finally, p-ERK and EGFR showed higher expression in malignant meningioma with high expression of CD47, which was verified by western blot., Conclusion: Our results demonstrated that CD47 maybe involved in the meningioma progression and prognosis and offered a novel therapeutic option by targeting CD47 in malignant meningioma., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)

Published
2023
Full Text
View/download PDF

45. Coexisting Cooperative Cognitive Micro-/Nanorobots.

Author

Chang X, Tang W, Feng Y, Yu H, Wu Z, Xu T, Dong H, and Li T

Subjects
Humans, Particle Size, Surface Properties, Microfluidic Analytical Techniques instrumentation, Nanotechnology
Abstract

Interaction behaviors are a crucial, distinctive feature of organisms in ecological systems. Inspired by nature, micro-/nanorobots also show interaction behaviors with a significant number of novel and advanced functionalities. The micro-/nanoscale size and self-driven abilities of micro-/nanorobots have attracted considerable attention for potential applications. The mission of micro-/nanorobots has evolved from basic mechanical transfer or assistance to a diverse range of complex tasks, such as targeted drug delivery, biosensing, and environmental remediation. Herein, we focus on the interaction behavior of coexisting cooperative cognitive (Tri-Co) micro-/nanorobots, summarize recent research, and classify the interactions into three broad types: with the environment, with robot peers, and with human external control., (© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results