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263 results on '"Feng, Jian‐feng"'

11. The genetic architecture of the human hypothalamus and its involvement in neuropsychiatric behaviours and disorders

Author

Chen, Shi-Dong, You, Jia, Zhang, Wei, Wu, Bang-Sheng, Ge, Yi-Jun, Xiang, Shi-Tong, Du, Jing, Kuo, Kevin, Banaschewski, Tobias, Barker, Gareth J., Bokde, Arun L. W., Desrivières, Sylvane, Flor, Herta, Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Brühl, Rüdiger, Martinot, Jean-Luc, Martinot, Marie-Laure Paillère, Artiges, Eric, Nees, Frauke, Orfanos, Dimitri Papadopoulos, Lemaitre, Herve, Paus, Tomáš, Poustka, Luise, Hohmann, Sarah, Millenet, Sabina, Baeuchl, Christian, Smolka, Michael N., Vaidya, Nilakshi, Walter, Henrik, Whelan, Robert, Schumann, Gunter, Feng, Jian-Feng, Dong, Qiang, Cheng, Wei, and Yu, Jin-Tai

Published
2024
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42. Whole exome sequencing analyses identified novel genes for Alzheimer's disease and related dementia.

Author

Zhang, Ya‐Ru, Wu, Bang‐Sheng, Chen, Shi‐Dong, Yang, Liu, Deng, Yue‐Ting, Guo, Yu, Wu, Xin‐Rui, Liu, Wei‐Shi, Kang, Ju‐Jiao, Feng, Jian‐Feng, Cheng, Wei, and Yu, Jin‐Tai

Abstract

INTRODUCTION: The heritability of Alzheimer's disease (AD) is estimated to be 58%–79%. However, known genes can only partially explain the heritability. METHODS: Here, we conducted gene‐based exome‐wide association study (ExWAS) of rare variants and single‐variant ExWAS of common variants, utilizing data of 54,569 clinically diagnosed/proxy AD and related dementia (ADRD) and 295,421 controls from the UK Biobank. RESULTS: Gene‐based ExWAS identified 11 genes predicting a higher ADRD risk, including five novel ones, namely FRMD8, DDX1, DNMT3L, MORC1, and TGM2, along with six previously reported ones, SORL1, GRN, PSEN1, ABCA7, GBA, and ADAM10. Single‐variant ExWAS identified two ADRD‐associated novel genes, SLCO1C1 and NDNF. The identified genes were predominantly enriched in amyloid‐β process pathways, microglia, and brain regions like hippocampus. The druggability evidence suggests that DDX1, DNMT3L, TGM2, SLCO1C1, and NDNF could be effective drug targets. DISCUSSION: Our study contributes to the current body of evidence on the genetic etiology of ADRD. Highlights: Gene‐based analyses of rare variants identified five novel genes for Alzheimer's disease and related dementia (ADRD), including FRMD8, DDX1, DNMT3L, MORC1, and TGM2.Single‐variant analyses of common variants identified two novel genes for ADRD, including SLCO1C1 and NDNF.The identified genes were predominantly enriched in amyloid‐β process pathways, microglia, and brain regions like hippocampus.DDX1, DNMT3L, TGM2, SLCO1C1, and NDNF could be effective drug targets. [ABSTRACT FROM AUTHOR]

Published
2024
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44. Osteoarthritis, osteoarthritis treatment and risk of incident dementia: a prospective cohort study based on UK Biobank.

Author

Guo, Rong, Ou, Ya-Nan, Ma, Li-Yun, Tang, Lian, Yang, Liu, Feng, Jian-Feng, Cheng, Wei, Tan, Lan, and Yu, Jin-Tai

Subjects
DEMENTIA risk factors, OSTEOARTHRITIS treatment, BRAIN anatomy, RISK assessment, RESEARCH funding, ALZHEIMER'S disease, DESCRIPTIVE statistics, VASCULAR dementia, MANN Whitney U Test, MULTIVARIATE analysis, LONGITUDINAL method, ANALYSIS of variance, DEMENTIA, CONFIDENCE intervals, REGRESSION analysis, PATIENT aftercare, PROPORTIONAL hazards models
Abstract

Background We aimed to investigate the association between OA and treatment with dementia risk and structural brain abnormalities. Methods We recruited a total of 466,460 individuals from the UK Biobank to investigate the impact of OA on the incidence of dementia. Among the total population, there were 63,081 participants diagnosed with OA. We subsequently categorised the OA patients into medication and surgery groups based on treatment routes. Cox regression models explored the associations between OA/OA treatment and dementia risk, with the results represented as hazard ratios (HRs) and 95% confidence intervals (95% CI). Linear regression models assessed the associations of OA/OA therapy with alterations in cortical structure. Results During an average of 11.90 (± 1.01) years of follow-up, 5,627 individuals were diagnosed with all-cause dementia (ACD), including 2,438 AD (Alzheimer's disease), and 1,312 VaD (vascular dementia) cases. Results revealed that OA was associated with the elevated risk of ACD (HR: 1.116; 95% CI: 1.039–1.199) and AD (HR: 1.127; 95% CI: 1.013–1.254). OA therapy lowered the risk of dementia in both medication group (HR: 0.746; 95% CI: 0.652–0.854) and surgery group (HR: 0.841; 95% CI: 0.736–0.960). OA was negatively associated with cortical area, especially precentral, postcentral and temporal regions. Conclusions Osteoarthritis increased the likelihood of developing dementia, and had an association with regional brain atrophy. OA treatment lowered the dementia risk. OA is a promising modifiable risk factor for dementia. [ABSTRACT FROM AUTHOR]

Published
2024
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45. Exome sequencing identifies novel genetic variants associated with varicose veins.

Author

Zhang, Dan-Dan, He, Xiao-Yu, Yang, Liu, Wu, Bang-Sheng, Fu, Yan, Liu, Wei-Shi, Guo, Yu, Fei, Chen-Jie, Kang, Ju-Jiao, Feng, Jian-Feng, Cheng, Wei, Tan, Lan, and Yu, Jin-Tai

Subjects
GENETIC variation, EXOMES, VARICOSE veins, GENOME-wide association studies, GENE mapping, BODY size
Abstract

Background: Varicose veins (VV) are one of the common human diseases, but the role of genetics in its development is not fully understood. Methods: We conducted an exome-wide association study of VV using whole-exome sequencing data from the UK Biobank, and focused on common and rare variants using single-variant association analysis and gene-level collapsing analysis. Findings: A total of 13,823,269 autosomal genetic variants were obtained after quality control. We identified 36 VV-related independent common variants mapping to 34 genes by single-variant analysis and three rare variant genes (PIEZO1, ECE1, FBLN7) by collapsing analysis, and most associations between genes and VV were replicated in FinnGen. PIEZO1 was the closest gene associated with VV (P = 5.05 × 10−31), and it was found to reach exome-wide significance in both single-variant and collapsing analyses. Two novel rare variant genes (ECE1 and METTL21A) associated with VV were identified, of which METTL21A was associated only with females. The pleiotropic effects of VV-related genes suggested that body size, inflammation, and pulmonary function are strongly associated with the development of VV. Conclusions: Our findings highlight the importance of causal genes for VV and provide new directions for treatment. Author summary: In this study, whole-exome sequencing data from the UK Biobank were used to explore the effect of genetic variants on varicose veins (VV) and search for new VV-related genes. In contrast to traditional association studies, large-scale whole-exome sequencing analysis is more capable of identifying rare genetic variants (MAF < 1%) in diseases. The current study identified 34 VV-associated common variant genes by single-variant analysis and three rare variant genes (PIEZO1, ECE1, FBLN7) by collapsing analysis, and most associations were validated in FinnGen. In addition to replicating several genes reported in previous genome-wide association studies, we identified 17 novel genes that may be associated with VV. Through subsequent phenome-wide association analyses of identified genes, we found that these genes are also strongly associated with body size, inflammation, and pulmonary function. These findings contribute to understanding the underlying mechanisms of pathogenesis and developing novel therapeutic strategies for VV. [ABSTRACT FROM AUTHOR]

Published
2024
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46. Glymphatic system dysfunction predicts amyloid deposition, neurodegeneration, and clinical progression in Alzheimer's disease.

Author

Huang, Shu‐Yi, Zhang, Ya‐Ru, Guo, Yu, Du, Jing, Ren, Peng, Wu, Bang‐Sheng, Feng, Jian‐Feng, Cheng, Wei, and Yu, Jin‐Tai

Abstract

INTRODUCTION: Although glymphatic function is involved in Alzheimer's disease (AD), its potential for predicting the pathological and clinical progression of AD and its sequential association with core AD biomarkers is poorly understood. METHODS: Whole‐brain glymphatic activity was measured by diffusion tensor image analysis along the perivascular space (DTI‐ALPS) in participants with AD dementia (n = 47), mild cognitive impairment (MCI; n = 137), and normal controls (n = 235) from the Alzheimer's Disease Neuroimaging Initiative. RESULTS: ALPS index was significantly lower in AD dementia than in MCI or controls. Lower ALPS index was significantly associated with faster changes in amyloid positron emission tomography (PET) burden and AD signature region of interest volume, higher risk of amyloid‐positive transition and clinical progression, and faster rates of amyloid‐ and neurodegeneration‐related cognitive decline. Furthermore, the associations of the ALPS index with cognitive decline were fully mediated by amyloid PET and brain atrophy. DISCUSSION: Glymphatic failure may precede amyloid pathology, and predicts amyloid deposition, neurodegeneration, and clinical progression in AD. Highlights: The analysis along the perivascular space (ALPS) index is reduced in patients with Alzheimer's disease (AD) dementia, prodromal AD, and preclinical AD.Lower ALPS index predicted accelerated amyloid beta (Aβ) positron emission tomography (PET) burden and Aβ‐positive transition.The decrease in the ALPS index occurs before cerebrospinal fluid Aβ42 reaches the positive threshold.ALPS index predicted brain atrophy, clinical progression, and cognitive decline.Aβ PET and brain atrophy mediated the link of ALPS index with cognitive decline. [ABSTRACT FROM AUTHOR]

Published
2024
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47. Socioeconomic status, lifestyle and risk of incident dementia: a prospective cohort study of 276730 participants

Author

Ou, Ya-Nan, primary, Zhang, Yan-Bo, additional, Li, Yu-Zhu, additional, Huang, Shu-Yi, additional, Zhang, Wei, additional, Deng, Yue-Ting, additional, Wu, Bang-Sheng, additional, Tan, Lan, additional, Dong, Qiang, additional, Pan, An, additional, Chen, Ren-Jie, additional, Feng, Jian-Feng, additional, Smith, A. David, additional, Cheng, Wei, additional, and Yu, Jin-Tai, additional

Published
2023
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50. Longitudinal associations of cardiovascular health and vascular events with incident dementia

Author

Ou, Ya-Nan, primary, Kuo, Kevin, additional, Yang, Liu, additional, Zhang, Ya-Ru, additional, Huang, Shu-Yi, additional, Chen, Shi-Dong, additional, Deng, Yue-Ting, additional, Guo, Yu, additional, Zhang, Rui-Qi, additional, Wu, Bang-Sheng, additional, Tan, Lan, additional, Dong, Qiang, additional, Feng, Jian-Feng, additional, Cheng, Wei, additional, and Yu, Jin-Tai, additional

Published
2023
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