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623 results on '"Feng, Jiachun"'

4. Context Reinforced Neural Topic Modeling over Short Texts

Author

Feng, Jiachun, Zhang, Zusheng, Ding, Cheng, Rao, Yanghui, and Xie, Haoran

Subjects
Computer Science - Information Retrieval, Computer Science - Computation and Language
Abstract

As one of the prevalent topic mining tools, neural topic modeling has attracted a lot of interests for the advantages of high efficiency in training and strong generalisation abilities. However, due to the lack of context in each short text, the existing neural topic models may suffer from feature sparsity on such documents. To alleviate this issue, we propose a Context Reinforced Neural Topic Model (CRNTM), whose characteristics can be summarized as follows. Firstly, by assuming that each short text covers only a few salient topics, CRNTM infers the topic for each word in a narrow range. Secondly, our model exploits pre-trained word embeddings by treating topics as multivariate Gaussian distributions or Gaussian mixture distributions in the embedding space. Extensive experiments on two benchmark datasets validate the effectiveness of the proposed model on both topic discovery and text classification.

Published
2020

13. Reward-Modulated Adversarial Topic Modeling

Author

Feng, Yuhao, Feng, Jiachun, Rao, Yanghui, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Nah, Yunmook, editor, Cui, Bin, editor, Lee, Sang-Won, editor, Yu, Jeffrey Xu, editor, Moon, Yang-Sae, editor, and Whang, Steven Euijong, editor

Published
2020
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17. Characterization of physiochemical properties of caveolin-1 from normal and prion-infected human brains.

Author

Xiao, Xiangzhu, Shen, Pingping, Wang, Zerui, Dang, Johnny, Adornato, Alise, Zou, Lewis, Dong, Zhiqian, Yuan, Jue, Feng, Jiachun, Cui, Li, and Zou, Wen-Quan

Subjects
Gerotarget, aggregation, caveolin-1, human brain, prion disease, solubility
Abstract

Caveolin-1 is a major component protein of the caveolae-a type of flask shaped, 50-100 nm, nonclathrin-coated, microdomain present in the plasma membrane of most mammalian cells. Caveolin-1 functions as a scaffolding protein to organize and concentrate signaling molecules within the caveolae, which may be associated with its unique physicochemical properties including oligomerization, acquisition of detergent insolubility, and association with cholesterol. Here we demonstrate that caveolin-1 is detected in all brain areas examined and recovered in both detergent-soluble and -insoluble fractions. Surprisingly, the recovered molecules from the two different fractions share a similar molecular size ranging from 200 to 2,000 kDa, indicated by gel filtration. Furthermore, both soluble and insoluble caveolin-1 molecules generate a proteinase K (PK)-resistant C-terminal core fragment upon the PK-treatment, by removing ˜36 amino acids from the N-terminus of the protein. Although it recognizes caveolin-1 from A431 cell lysate, an antibody against the C-terminus of caveolin-1 fails to detect the brain protein by Western blotting, suggesting that the epitope in the brain caveolin-1 is concealed. No significant differences in the physicochemical properties of caveolin-1 between uninfected and prion-infected brains are observed.

Published
2017

42. In Vitro Seeding Activity of Glycoform-Deficient Prions from Variably Protease-Sensitive Prionopathy and Familial CJD Associated with PrPV180I Mutation

Author

Wang, Zerui, Yuan, Jue, Shen, Pingping, Abskharon, Romany, Lang, Yue, Dang, Johnny, Adornato, Alise, Xu, Ling, Chen, Jiafeng, Feng, Jiachun, Moudjou, Mohammed, Kitamoto, Tetsuyuki, Lee, Hyoung-gon, Kim, Yong-Sun, Langeveld, Jan, Appleby, Brian, Ma, Jiyan, Kong, Qingzhong, Petersen, Robert B., Zou, Wen-Quan, and Cui, Li

Published
2019
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