Search

Your search keyword '"Feng, Hua‐Jun"' showing total 349 results
Start Over Author "Feng, Hua‐Jun"
349 results on '"Feng, Hua‐Jun"'

25. 5-HT receptors exert differential effects on seizure-induced respiratory arrest in DBA/1 mice.

Author

Pan, Yundan, Tan, Zheren, Guo, Jialing, and Feng, Hua-Jun

Subjects
FISHER exact test, MICE, SUDDEN death
Abstract

Both clinical and animal studies demonstrated that seizure-induced respiratory arrest (S-IRA) contributes importantly to sudden unexpected death in epilepsy (SUDEP). It has been shown that enhancing serotonin (5-HT) function relieves S-IRA in animal models of SUDEP, including DBA/1 mice. Direct activation of 5-HT3 and 5-HT4 receptors suppresses S-IRA in DBA/1 mice, indicating that these receptors are involved in S-IRA. However, it remains unknown if other subtypes of 5-HT receptors are implicated in S-IRA in DBA/1 mice. In this study, we investigated the action of an agonist of the 5-HT1A (8-OH-DPAT), 5-HT2A (TCB-2), 5-HT2B (BW723C86), 5-HT2C (MK-212), 5-HT6 (WAY-208466) and 5-HT7 (LP-211) receptor on S-IRA in DBA/1 mice. An agonist of the 5-HT receptor or a vehicle was intraperitoneally administered 30 min prior to acoustic simulation, and the effect of each drug/vehicle on the incidence of S-IRA was videotaped for offline analysis. We found that the incidence of S-IRA was significantly reduced by TCB-2 at 10 mg/kg (30%, n = 10; p < 0.01, Fisher's exact test) but was not altered by other agonists compared with the corresponding vehicle controls in DBA/1 mice. Our data demonstrate that 5-HT2A receptors are implicated in S-IRA, and 5-HT1A, 5-HT2B, 5-HT2C, 5-HT6 and 5-HT7 receptors are not involved in S-IRA in DBA/1 mice. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

29. Interspecies electron transfer between Geobacter and denitrifying bacteria for nitrogen removal in bioelectrochemical system

Author

Guo, Wei, Ying, Xian-Bin, Zhao, Nan-Nan, Yu, Sheng-Song, Zhang, Xu, Feng, Hua-Jun, Zhang, Yi-Feng, Yu, Han-Qing, Guo, Wei, Ying, Xian-Bin, Zhao, Nan-Nan, Yu, Sheng-Song, Zhang, Xu, Feng, Hua-Jun, Zhang, Yi-Feng, and Yu, Han-Qing

Abstract

Groundwater nitrate pollution is a severe environmental problem causing global concern. Among others, autotrophic denitrification on polarized electrodes is one of the energy-efficient and sustainable solutions. However, the poor nitrogen-removal rate severely hinders the application of this process. Herein, biofilms consisted of the symbiotic growth of Geobacter and denitrifying bacteria with interspecies electron transfer ability were formed on carbon paper electrodes through periodic polarity inversion. The biofilm with an inversion period of 12h obtained the highest cathode current density (2.19 A/m2 on average), and the total nitrogen removal rate reached 4.98 g/m2Ca/d, which was an order of magnitude higher than that of the control cathode (current density 0.13 A/m2, total nitrogen removal rate 0.52 g/m2Ca/d). The excellent performance of the biofilms was attributed to the symbiotic interactions between Geobacter and denitrifying bacteria, in which Geobacter transferred electrons from the electrodes to the denitrifying bacteria for denitrification via cytochrome c-like species. Such an electron transfer process was further verified by suppressing current generation and denitrification through dosing either electron transfer inhibitors or denitrifying inhibitors. This work reveals a new extracellular electron transfer mechanism underlying the autotrophic denitrification on the cathode electrode and provides an insight into the development of efficient biocathodes for treating nitrate pollution in groundwater.

Published
2023

Catalog

Books, media, physical & digital resources
See catalog results