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Multimodal Large Language Models (MLLMs) demonstrate remarkable performance across a wide range of domains, with increasing emphasis on enhancing their zero-shot generalization capabilities for unseen tasks across various modalities. Instruction tuning has emerged as an effective strategy for achieving zero-shot generalization by finetuning pretrained models on diverse multimodal tasks. As the scale of MLLMs continues to grow, parameter-efficient finetuning becomes increasingly critical. However, most existing parameter-efficient approaches focus only on single modalities and often overlook the multimodal characteristics during finetuning. In this work, we introduce a novel Multimodal Prompt Tuning (M$^2$PT) approach for efficient instruction tuning of MLLMs. M$^2$PT effectively integrates visual and textual prompts into the vision encoder and language processor respectively during finetuning, facilitating the extraction and alignment of features across modalities. Empirical results on various multimodal evaluation datasets demonstrate the superior performance of our approach compared to several state-of-the-art baselines. A comprehensive set of ablation studies validates the effectiveness of our prompt design and the efficiency of our approach., Comment: EMNLP 2024

Recommending items solely catering to users' historical interests narrows users' horizons. Recent works have considered steering target users beyond their historical interests by directly adjusting items exposed to them. However, the recommended items for direct steering might not align perfectly with users' interests evolution, detrimentally affecting target users' experience. To avoid this issue, we propose a new task named Proactive Recommendation in Social Networks (PRSN) that indirectly steers users' interest by utilizing the influence of social neighbors, i.e., indirect steering by adjusting the exposure of a target item to target users' neighbors. The key to PRSN lies in answering an interventional question: what would a target user's feedback be on a target item if the item is exposed to the user's different neighbors? To answer this question, we resort to causal inference and formalize PRSN as: (1) estimating the potential feedback of a user on an item, under the network interference by the item's exposure to the user's neighbors; and (2) adjusting the exposure of a target item to target users' neighbors to trade off steering performance and the damage to the neighbors' experience. To this end, we propose a Neighbor Interference Recommendation (NIRec) framework with two key modules: (1)an interference representation-based estimation module for modeling potential feedback; and (2) a post-learning-based optimization module for optimizing a target item's exposure to trade off steering performance and the neighbors' experience by greedy search. We conduct extensive semi-simulation experiments based on three real-world datasets, validating the steering effectiveness of NIRec.

Recommender systems aim to capture users' personalized preferences from the cast amount of user behaviors, making them pivotal in the era of information explosion. However, the presence of the dynamic preference, the "information cocoons", and the inherent feedback loops in recommendation make users interact with a limited number of items. Conventional recommendation algorithms typically focus on the positive historical behaviors, while neglecting the essential role of negative feedback in user interest understanding. As a promising but easy-to-ignored area, negative sampling is proficients in revealing the genuine negative aspect inherent in user behaviors, emerging as an inescapable procedure in recommendation. In this survey, we first discuss the role of negative sampling in recommendation and thoroughly analyze challenges that consistently impede its progress. Then, we conduct an extensive literature review on the existing negative sampling strategies in recommendation and classify them into five categories with their discrepant techniques. Finally, we detail the insights of the tailored negative sampling strategies in diverse recommendation scenarios and outline an overview of the prospective research directions toward which the community may engage and benefit., Comment: 38 pages, 9 figures; Under review

Recommender systems have achieved increasing accuracy over the years. However, this precision often leads users to narrow their interests, resulting in issues such as limited diversity and the creation of echo chambers. Current research addresses these challenges through proactive recommender systems by recommending a sequence of items (called influence path) to guide user interest in the target item. However, existing methods struggle to construct a coherent influence path that builds up with items the user is likely to enjoy. In this paper, we leverage the Large Language Model's (LLMs) exceptional ability for path planning and instruction following, introducing a novel approach named LLM-based Influence Path Planning (LLM-IPP). Our approach maintains coherence between consecutive recommendations and enhances user acceptability of the recommended items. To evaluate LLM-IPP, we implement various user simulators and metrics to measure user acceptability and path coherence. Experimental results demonstrate that LLM-IPP significantly outperforms traditional proactive recommender systems. This study pioneers the integration of LLMs into proactive recommender systems, offering a reliable and user-engaging methodology for future recommendation technologies., Comment: 5 pages, 1 figure

Recent work has improved recommendation models remarkably by equipping them with debiasing methods. Due to the unavailability of fully-exposed datasets, most existing approaches resort to randomly-exposed datasets as a proxy for evaluating debiased models, employing traditional evaluation scheme to represent the recommendation performance. However, in this study, we reveal that traditional evaluation scheme is not suitable for randomly-exposed datasets, leading to inconsistency between the Recall performance obtained using randomly-exposed datasets and that obtained using fully-exposed datasets. Such inconsistency indicates the potential unreliability of experiment conclusions on previous debiasing techniques and calls for unbiased Recall evaluation using randomly-exposed datasets. To bridge the gap, we propose the Unbiased Recall Evaluation (URE) scheme, which adjusts the utilization of randomly-exposed datasets to unbiasedly estimate the true Recall performance on fully-exposed datasets. We provide theoretical evidence to demonstrate the rationality of URE and perform extensive experiments on real-world datasets to validate its soundness., Comment: 11 pages, 5 figures

With recent generative models facilitating photo-realistic image synthesis, the proliferation of synthetic images has also engendered certain negative impacts on social platforms, thereby raising an urgent imperative to develop effective detectors. Current synthetic image detection (SID) pipelines are primarily dedicated to crafting universal artifact features, accompanied by an oversight about SID training paradigm. In this paper, we re-examine the SID problem and identify two prevalent biases in current training paradigms, i.e., weakened artifact features and overfitted artifact features. Meanwhile, we discover that the imaging mechanism of synthetic images contributes to heightened local correlations among pixels, suggesting that detectors should be equipped with local awareness. In this light, we propose SAFE, a lightweight and effective detector with three simple image transformations. Firstly, for weakened artifact features, we substitute the down-sampling operator with the crop operator in image pre-processing to help circumvent artifact distortion. Secondly, for overfitted artifact features, we include ColorJitter and RandomRotation as additional data augmentations, to help alleviate irrelevant biases from color discrepancies and semantic differences in limited training samples. Thirdly, for local awareness, we propose a patch-based random masking strategy tailored for SID, forcing the detector to focus on local regions at training. Comparative experiments are conducted on an open-world dataset, comprising synthetic images generated by 26 distinct generative models. Our pipeline achieves a new state-of-the-art performance, with remarkable improvements of 4.5% in accuracy and 2.9% in average precision against existing methods.

Recommender systems require the simultaneous optimization of multiple objectives to accurately model user interests, necessitating the application of multi-task learning methods. However, existing multi-task learning methods in recommendations overlook the specific characteristics of recommendation scenarios, falling short in achieving proper gradient balance. To address this challenge, we set the target of multi-task learning as attaining the appropriate magnitude balance and the global direction balance, and propose an innovative methodology named GradCraft in response. GradCraft dynamically adjusts gradient magnitudes to align with the maximum gradient norm, mitigating interference from gradient magnitudes for subsequent manipulation. It then employs projections to eliminate gradient conflicts in directions while considering all conflicting tasks simultaneously, theoretically guaranteeing the global resolution of direction conflicts. GradCraft ensures the concurrent achievement of appropriate magnitude balance and global direction balance, aligning with the inherent characteristics of recommendation scenarios. Both offline and online experiments attest to the efficacy of GradCraft in enhancing multi-task performance in recommendations. The source code for GradCraft can be accessed at https://github.com/baiyimeng/GradCraft., Comment: Accepted by KDD'24

Model inversion attacks (MIAs) aim to reconstruct private images from a target classifier's training set, thereby raising privacy concerns in AI applications. Previous GAN-based MIAs tend to suffer from inferior generative fidelity due to GAN's inherent flaws and biased optimization within latent space. To alleviate these issues, leveraging on diffusion models' remarkable synthesis capabilities, we propose Diffusion-based Model Inversion (Diff-MI) attacks. Specifically, we introduce a novel target-specific conditional diffusion model (CDM) to purposely approximate target classifier's private distribution and achieve superior accuracy-fidelity balance. Our method involves a two-step learning paradigm. Step-1 incorporates the target classifier into the entire CDM learning under a pretrain-then-finetune fashion, with creating pseudo-labels as model conditions in pretraining and adjusting specified layers with image predictions in fine-tuning. Step-2 presents an iterative image reconstruction method, further enhancing the attack performance through a combination of diffusion priors and target knowledge. Additionally, we propose an improved max-margin loss that replaces the hard max with top-k maxes, fully leveraging feature information and soft labels from the target classifier. Extensive experiments demonstrate that Diff-MI significantly improves generative fidelity with an average decrease of 20% in FID while maintaining competitive attack accuracy compared to state-of-the-art methods across various datasets and models. We will release our code and models., Comment: Preprint. Under review

Active clustering aims to boost the clustering performance by integrating human-annotated pairwise constraints through strategic querying. Conventional approaches with semi-supervised clustering schemes encounter high query costs when applied to large datasets with numerous classes. To address these limitations, we propose a novel Adaptive Active Aggregation and Splitting (A3S) framework, falling within the cluster-adjustment scheme in active clustering. A3S features strategic active clustering adjustment on the initial cluster result, which is obtained by an adaptive clustering algorithm. In particular, our cluster adjustment is inspired by the quantitative analysis of Normalized mutual information gain under the information theory framework and can provably improve the clustering quality. The proposed A3S framework significantly elevates the performance and scalability of active clustering. In extensive experiments across diverse real-world datasets, A3S achieves desired results with significantly fewer human queries compared with existing methods.

Ratings of a user to most items in recommender systems are usually missing not at random (MNAR), largely because users are free to choose which items to rate. To achieve unbiased learning of the prediction model under MNAR data, three typical solutions have been proposed, including error-imputation-based (EIB), inverse-propensity-scoring (IPS), and doubly robust (DR) methods. However, these methods ignore an alternative form of bias caused by the inconsistency between the observed ratings and the users' true preferences, also known as noisy feedback or outcome measurement errors (OME), e.g., due to public opinion or low-quality data collection process. In this work, we study intersectional threats to the unbiased learning of the prediction model from data MNAR and OME in the collected data. First, we design OME-EIB, OME-IPS, and OME-DR estimators, which largely extend the existing estimators to combat OME in real-world recommendation scenarios. Next, we theoretically prove the unbiasedness and generalization bound of the proposed estimators. We further propose an alternate denoising training approach to achieve unbiased learning of the prediction model under MNAR data with OME. Extensive experiments are conducted on three real-world datasets and one semi-synthetic dataset to show the effectiveness of our proposed approaches. The code is available at https://github.com/haoxuanli-pku/KDD24-OME-DR., Comment: KDD 24 Research Track Paper

Adapting Large Language Models (LLMs) for recommendation requires careful consideration of the decoding process, given the inherent differences between generating items and natural language. Existing approaches often directly apply LLMs' original decoding methods. However, we find these methods encounter significant challenges: 1) amplification bias -- where standard length normalization inflates scores for items containing tokens with generation probabilities close to 1 (termed ghost tokens), and 2) homogeneity issue -- generating multiple similar or repetitive items for a user. To tackle these challenges, we introduce a new decoding approach named Debiasing-Diversifying Decoding (D3). D3 disables length normalization for ghost tokens to alleviate amplification bias, and it incorporates a text-free assistant model to encourage tokens less frequently generated by LLMs for counteracting recommendation homogeneity. Extensive experiments on real-world datasets demonstrate the method's effectiveness in enhancing accuracy and diversity.

Adapting Large Language Models (LLMs) for agent tasks is critical in developing language agents. Direct Preference Optimization (DPO) is a promising technique for this adaptation with the alleviation of compounding errors, offering a means to directly optimize Reinforcement Learning (RL) objectives. However, applying DPO to multi-turn tasks presents challenges due to the inability to cancel the partition function. Overcoming this obstacle involves making the partition function independent of the current state and addressing length disparities between preferred and dis-preferred trajectories. In this light, we replace the policy constraint with the state-action occupancy measure constraint in the RL objective and add length normalization to the Bradley-Terry model, yielding a novel loss function named DMPO for multi-turn agent tasks with theoretical explanations. Extensive experiments on three multi-turn agent task datasets confirm the effectiveness and superiority of the DMPO loss.

Gradient-free prompt optimization methods have made significant strides in enhancing the performance of closed-source Large Language Models (LLMs) across a wide range of tasks. However, existing approaches make light of the importance of high-quality prompt initialization and the identification of effective optimization directions, thus resulting in substantial optimization steps to obtain satisfactory performance. In this light, we aim to accelerate prompt optimization process to tackle the challenge of low convergence rate. We propose a dual-phase approach which starts with generating high-quality initial prompts by adopting a well-designed meta-instruction to delve into task-specific information, and iteratively optimize the prompts at the sentence level, leveraging previous tuning experience to expand prompt candidates and accept effective ones. Extensive experiments on eight datasets demonstrate the effectiveness of our proposed method, achieving a consistent accuracy gain over baselines with less than five optimization steps.

Retrieval-Augmented Generation (RAG) can alleviate hallucinations of Large Language Models (LLMs) by referencing external documents. However, the misinformation in external documents may mislead LLMs' generation. To address this issue, we explore the task of "credibility-aware RAG", in which LLMs automatically adjust the influence of retrieved documents based on their credibility scores to counteract misinformation. To this end, we introduce a plug-and-play method named $\textbf{Cr}$edibility-aware $\textbf{A}$ttention $\textbf{M}$odification (CrAM). CrAM identifies influential attention heads in LLMs and adjusts their attention weights based on the credibility of the documents, thereby reducing the impact of low-credibility documents. Experiments on Natual Questions and TriviaQA using Llama2-13B, Llama3-8B, and Qwen-7B show that CrAM improves the RAG performance of LLMs against misinformation pollution by over 20%, even surpassing supervised fine-tuning methods., Comment: Under review

Large Language Models (LLMs) excel in various natural language processing tasks but struggle with hallucination issues. Existing solutions have considered utilizing LLMs' inherent reasoning abilities to alleviate hallucination, such as self-correction and diverse sampling methods. However, these methods often overtrust LLMs' initial answers due to inherent biases. The key to alleviating this issue lies in overriding LLMs' inherent biases for answer inspection. To this end, we propose a CounterFactual Multi-Agent Debate (CFMAD) framework. CFMAD presets the stances of LLMs to override their inherent biases by compelling LLMs to generate justifications for a predetermined answer's correctness. The LLMs with different predetermined stances are engaged with a skeptical critic for counterfactual debate on the rationality of generated justifications. Finally, the debate process is evaluated by a third-party judge to determine the final answer. Extensive experiments on four datasets of three tasks demonstrate the superiority of CFMAD over existing methods.

Product attribute value extraction involves identifying the specific values associated with various attributes from a product profile. While existing methods often prioritize the development of effective models to improve extraction performance, there has been limited emphasis on extraction efficiency. However, in real-world scenarios, products are typically associated with multiple attributes, necessitating multiple extractions to obtain all corresponding values. In this work, we propose an Efficient product Attribute Value Extraction (EAVE) approach via lightweight sparse-layer interaction. Specifically, we employ a heavy encoder to separately encode the product context and attribute. The resulting non-interacting heavy representations of the context can be cached and reused for all attributes. Additionally, we introduce a light encoder to jointly encode the context and the attribute, facilitating lightweight interactions between them. To enrich the interaction within the lightweight encoder, we design a sparse-layer interaction module to fuse the non-interacting heavy representation into the lightweight encoder. Comprehensive evaluation on two benchmarks demonstrate that our method achieves significant efficiency gains with neutral or marginal loss in performance when the context is long and number of attributes is large. Our code is available \href{https://anonymous.4open.science/r/EAVE-EA18}{here}.

Fairness has become a crucial aspect in the development of trustworthy machine learning algorithms. Current fairness metrics to measure the violation of demographic parity have the following drawbacks: (i) the average difference of model predictions on two groups cannot reflect their distribution disparity, and (ii) the overall calculation along all possible predictions conceals the extreme local disparity at or around certain predictions. In this work, we propose a novel fairness metric called Maximal Cumulative ratio Disparity along varying Predictions' neighborhood (MCDP), for measuring the maximal local disparity of the fairness-aware classifiers. To accurately and efficiently calculate the MCDP, we develop a provably exact and an approximate calculation algorithm that greatly reduces the computational complexity with low estimation error. We further propose a bi-level optimization algorithm using a differentiable approximation of the MCDP for improving the algorithmic fairness. Extensive experiments on both tabular and image datasets validate that our fair training algorithm can achieve superior fairness-accuracy trade-offs.

When adapting Large Language Models for Recommendation (LLMRec), it is crucial to integrate collaborative information. Existing methods achieve this by learning collaborative embeddings in LLMs' latent space from scratch or by mapping from external models. However, they fail to represent the information in a text-like format, which may not align optimally with LLMs. To bridge this gap, we introduce BinLLM, a novel LLMRec method that seamlessly integrates collaborative information through text-like encoding. BinLLM converts collaborative embeddings from external models into binary sequences -- a specific text format that LLMs can understand and operate on directly, facilitating the direct usage of collaborative information in text-like format by LLMs. Additionally, BinLLM provides options to compress the binary sequence using dot-decimal notation to avoid excessively long lengths. Extensive experiments validate that BinLLM introduces collaborative information in a manner better aligned with LLMs, resulting in enhanced performance. We release our code at https://github.com/zyang1580/BinLLM., Comment: Accepted by ACL 2024

The rapid advancement of Large Language Models (LLMs) in the realm of mathematical reasoning necessitates comprehensive evaluations to gauge progress and inspire future directions. Existing assessments predominantly focus on problem-solving from the examinee perspective, overlooking a dual perspective of examiner regarding error identification and correction. From the examiner perspective, we define four evaluation tasks for error identification and correction along with a new dataset with annotated error types and steps. We also design diverse prompts to thoroughly evaluate eleven representative LLMs. Our principal findings indicate that GPT-4 outperforms all models, while open-source model LLaMA-2-7B demonstrates comparable abilities to closed-source models GPT-3.5 and Gemini Pro. Notably, calculation error proves the most challenging error type. Moreover, prompting LLMs with the error types can improve the average correction accuracy by 47.9\%. These results reveal potential directions for developing the mathematical reasoning abilities of LLMs. Our code and dataset is available on https://github.com/LittleCirc1e/EIC., Comment: ACL Findings 2024

Recommendation performance usually exhibits a long-tail distribution over users -- a small portion of head users enjoy much more accurate recommendation services than the others. We reveal two sources of this performance heterogeneity problem: the uneven distribution of historical interactions (a natural source); and the biased training of recommender models (a model source). As addressing this problem cannot sacrifice the overall performance, a wise choice is to eliminate the model bias while maintaining the natural heterogeneity. The key to debiased training lies in eliminating the effect of confounders that influence both the user's historical behaviors and the next behavior. The emerging causal recommendation methods achieve this by modeling the causal effect between user behaviors, however potentially neglect unobserved confounders (\eg, friend suggestions) that are hard to measure in practice. To address unobserved confounders, we resort to the front-door adjustment (FDA) in causal theory and propose a causal multi-teacher distillation framework (CausalD). FDA requires proper mediators in order to estimate the causal effects of historical behaviors on the next behavior. To achieve this, we equip CausalD with multiple heterogeneous recommendation models to model the mediator distribution. Then, the causal effect estimated by FDA is the expectation of recommendation prediction over the mediator distribution and the prior distribution of historical behaviors, which is technically achieved by multi-teacher ensemble. To pursue efficient inference, CausalD further distills multiple teachers into one student model to directly infer the causal effect for making recommendations., Comment: TKDE 2023

Utilizing powerful Large Language Models (LLMs) for generative recommendation has attracted much attention. Nevertheless, a crucial challenge is transforming recommendation data into the language space of LLMs through effective item tokenization. Current approaches, such as ID, textual, and codebook-based identifiers, exhibit shortcomings in encoding semantic information, incorporating collaborative signals, or handling code assignment bias. To address these limitations, we propose LETTER (a LEarnable Tokenizer for generaTivE Recommendation), which integrates hierarchical semantics, collaborative signals, and code assignment diversity to satisfy the essential requirements of identifiers. LETTER incorporates Residual Quantized VAE for semantic regularization, a contrastive alignment loss for collaborative regularization, and a diversity loss to mitigate code assignment bias. We instantiate LETTER on two models and propose a ranking-guided generation loss to augment their ranking ability theoretically. Experiments on three datasets validate the superiority of LETTER, advancing the state-of-the-art in the field of LLM-based generative recommendation., Comment: Accepted by CIKM 2024

As recommender systems are indispensable in various domains such as job searching and e-commerce, providing equitable recommendations to users with different sensitive attributes becomes an imperative requirement. Prior approaches for enhancing fairness in recommender systems presume the availability of all sensitive attributes, which can be difficult to obtain due to privacy concerns or inadequate means of capturing these attributes. In practice, the efficacy of these approaches is limited, pushing us to investigate ways of promoting fairness with limited sensitive attribute information. Toward this goal, it is important to reconstruct missing sensitive attributes. Nevertheless, reconstruction errors are inevitable due to the complexity of real-world sensitive attribute reconstruction problems and legal regulations. Thus, we pursue fair learning methods that are robust to reconstruction errors. To this end, we propose Distributionally Robust Fair Optimization (DRFO), which minimizes the worst-case unfairness over all potential probability distributions of missing sensitive attributes instead of the reconstructed one to account for the impact of the reconstruction errors. We provide theoretical and empirical evidence to demonstrate that our method can effectively ensure fairness in recommender systems when only limited sensitive attributes are accessible., Comment: 8 pages, 5 figures, accepted by SIGIR'24

Selection bias in recommender system arises from the recommendation process of system filtering and the interactive process of user selection. Many previous studies have focused on addressing selection bias to achieve unbiased learning of the prediction model, but ignore the fact that potential outcomes for a given user-item pair may vary with the treatments assigned to other user-item pairs, named neighborhood effect. To fill the gap, this paper formally formulates the neighborhood effect as an interference problem from the perspective of causal inference and introduces a treatment representation to capture the neighborhood effect. On this basis, we propose a novel ideal loss that can be used to deal with selection bias in the presence of neighborhood effect. We further develop two new estimators for estimating the proposed ideal loss. We theoretically establish the connection between the proposed and previous debiasing methods ignoring the neighborhood effect, showing that the proposed methods can achieve unbiased learning when both selection bias and neighborhood effect are present, while the existing methods are biased. Extensive semi-synthetic and real-world experiments are conducted to demonstrate the effectiveness of the proposed methods., Comment: ICLR 24

With the information explosion on the Web, search and recommendation are foundational infrastructures to satisfying users' information needs. As the two sides of the same coin, both revolve around the same core research problem, matching queries with documents or users with items. In the recent few decades, search and recommendation have experienced synchronous technological paradigm shifts, including machine learning-based and deep learning-based paradigms. Recently, the superintelligent generative large language models have sparked a new paradigm in search and recommendation, i.e., generative search (retrieval) and recommendation, which aims to address the matching problem in a generative manner. In this paper, we provide a comprehensive survey of the emerging paradigm in information systems and summarize the developments in generative search and recommendation from a unified perspective. Rather than simply categorizing existing works, we abstract a unified framework for the generative paradigm and break down the existing works into different stages within this framework to highlight the strengths and weaknesses. And then, we distinguish generative search and recommendation with their unique challenges, identify open problems and future directions, and envision the next information-seeking paradigm.

The evolving paradigm of Large Language Model-based Recommendation (LLMRec) customizes Large Language Models (LLMs) through parameter-efficient fine-tuning (PEFT) using recommendation data. The inclusion of user data in LLMs raises privacy concerns. To protect users, the unlearning process in LLMRec, specifically removing unusable data (e.g., historical behaviors) from established LLMRec models, becomes crucial. However, existing unlearning methods are insufficient for the unique characteristics of LLM-Rec, mainly due to high computational costs or incomplete data erasure. In this study, we introduce the Adapter Partition and Aggregation (APA) framework for exact and efficient unlearning while maintaining recommendation performance. APA achieves this by establishing distinct adapters for partitioned training data shards and retraining only the adapters impacted by unusable data for unlearning. To preserve recommendation performance and mitigate considerable inference costs, APA employs parameter-level adapter aggregation with sample-adaptive attention for individual testing samples. Extensive experiments substantiate the effectiveness and efficiency of our proposed framework

Medication recommendation systems have gained significant attention in healthcare as a means of providing tailored and effective drug combinations based on patients' clinical information. However, existing approaches often suffer from fairness issues, as recommendations tend to be more accurate for patients with common diseases compared to those with rare conditions. In this paper, we propose a novel model called Robust and Accurate REcommendations for Medication (RAREMed), which leverages the pretrain-finetune learning paradigm to enhance accuracy for rare diseases. RAREMed employs a transformer encoder with a unified input sequence approach to capture complex relationships among disease and procedure codes. Additionally, it introduces two self-supervised pre-training tasks, namely Sequence Matching Prediction (SMP) and Self Reconstruction (SR), to learn specialized medication needs and interrelations among clinical codes. Experimental results on two real-world datasets demonstrate that RAREMed provides accurate drug sets for both rare and common disease patients, thereby mitigating unfairness in medication recommendation systems.

Self-detection for Large Language Models (LLMs) seeks to evaluate the trustworthiness of the LLM's output by leveraging its own capabilities, thereby alleviating the issue of output hallucination. However, existing self-detection approaches only retrospectively evaluate answers generated by LLM, typically leading to the over-trust in incorrectly generated answers. To tackle this limitation, we propose a novel self-detection paradigm that considers the comprehensive answer space beyond LLM-generated answers. It thoroughly compares the trustworthiness of multiple candidate answers to mitigate the over-trust in LLM-generated incorrect answers. Building upon this paradigm, we introduce a two-step framework, which firstly instructs LLM to reflect and provide justifications for each candidate answer, and then aggregates the justifications for comprehensive target answer evaluation. This framework can be seamlessly integrated with existing approaches for superior self-detection. Extensive experiments on six datasets spanning three tasks demonstrate the effectiveness of the proposed framework., Comment: EMNLP findings 2024

Recommender systems mainly tailor personalized recommendations according to user interests learned from user feedback. However, such recommender systems passively cater to user interests and even reinforce existing interests in the feedback loop, leading to problems like filter bubbles and opinion polarization. To counteract this, proactive recommendation actively steers users towards developing new interests in a target item or topic by strategically modulating recommendation sequences. Existing work for proactive recommendation faces significant hurdles: 1) overlooking the user feedback in the guidance process; 2) lacking explicit modeling of the guiding objective; and 3) insufficient flexibility for integration into existing industrial recommender systems. To address these issues, we introduce an Iterative Preference Guidance (IPG) framework. IPG performs proactive recommendation in a flexible post-processing manner by ranking items according to their IPG scores that consider both interaction probability and guiding value. These scores are explicitly estimated with iteratively updated user representation that considers the most recent user interactions. Extensive experiments validate that IPG can effectively guide user interests toward target interests with a reasonable trade-off in recommender accuracy. The code is available at https://github.com/GabyUSTC/IPG-Rec., Comment: Accepted by WWW 2024 (Short)

The rise of generative models has driven significant advancements in recommender systems, leaving unique opportunities for enhancing users' personalized recommendations. This workshop serves as a platform for researchers to explore and exchange innovative concepts related to the integration of generative models into recommender systems. It primarily focuses on five key perspectives: (i) improving recommender algorithms, (ii) generating personalized content, (iii) evolving the user-system interaction paradigm, (iv) enhancing trustworthiness checks, and (v) refining evaluation methodologies for generative recommendations. With generative models advancing rapidly, an increasing body of research is emerging in these domains, underscoring the timeliness and critical importance of this workshop. The related research will introduce innovative technologies to recommender systems and contribute to fresh challenges in both academia and industry. In the long term, this research direction has the potential to revolutionize the traditional recommender paradigms and foster the development of next-generation recommender systems.

Recommender systems are vulnerable to injective attacks, which inject limited fake users into the platforms to manipulate the exposure of target items to all users. In this work, we identify that conventional injective attackers overlook the fact that each item has its unique potential audience, and meanwhile, the attack difficulty across different users varies. Blindly attacking all users will result in a waste of fake user budgets and inferior attack performance. To address these issues, we focus on an under-explored attack task called target user attacks, aiming at promoting target items to a particular user group. In addition, we formulate the varying attack difficulty as heterogeneous treatment effects through a causal lens and propose an Uplift-guided Budget Allocation (UBA) framework. UBA estimates the treatment effect on each target user and optimizes the allocation of fake user budgets to maximize the attack performance. Theoretical and empirical analysis demonstrates the rationality of treatment effect estimation methods of UBA. By instantiating UBA on multiple attackers, we conduct extensive experiments on three datasets under various settings with different target items, target users, fake user budgets, victim models, and defense models, validating the effectiveness and robustness of UBA., Comment: Accepted by WWW'24 as an oral paper

Optimization metrics are crucial for building recommendation systems at scale. However, an effective and efficient metric for practical use remains elusive. While Top-K ranking metrics are the gold standard for optimization, they suffer from significant computational overhead. Alternatively, the more efficient accuracy and AUC metrics often fall short of capturing the true targets of recommendation tasks, leading to suboptimal performance. To overcome this dilemma, we propose a new optimization metric, Lower-Left Partial AUC (LLPAUC), which is computationally efficient like AUC but strongly correlates with Top-K ranking metrics. Compared to AUC, LLPAUC considers only the partial area under the ROC curve in the Lower-Left corner to push the optimization focus on Top-K. We provide theoretical validation of the correlation between LLPAUC and Top-K ranking metrics and demonstrate its robustness to noisy user feedback. We further design an efficient point-wise recommendation loss to maximize LLPAUC and evaluate it on three datasets, validating its effectiveness and robustness., Comment: WWW 2024; 15 pages

Planning for both immediate and long-term benefits becomes increasingly important in recommendation. Existing methods apply Reinforcement Learning (RL) to learn planning capacity by maximizing cumulative reward for long-term recommendation. However, the scarcity of recommendation data presents challenges such as instability and susceptibility to overfitting when training RL models from scratch, resulting in sub-optimal performance. In this light, we propose to leverage the remarkable planning capabilities over sparse data of Large Language Models (LLMs) for long-term recommendation. The key to achieving the target lies in formulating a guidance plan following principles of enhancing long-term engagement and grounding the plan to effective and executable actions in a personalized manner. To this end, we propose a Bi-level Learnable LLM Planner framework, which consists of a set of LLM instances and breaks down the learning process into macro-learning and micro-learning to learn macro-level guidance and micro-level personalized recommendation policies, respectively. Extensive experiments validate that the framework facilitates the planning ability of LLMs for long-term recommendation. Our code and data can be found at https://github.com/jizhi-zhang/BiLLP., Comment: 11 pages, 5 figures

The new kind of Agent-oriented information system, exemplified by GPTs, urges us to inspect the information system infrastructure to support Agent-level information processing and to adapt to the characteristics of Large Language Model (LLM)-based Agents, such as interactivity. In this work, we envisage the prospect of the recommender system on LLM-based Agent platforms and introduce a novel recommendation paradigm called Rec4Agentverse, comprised of Agent Items and Agent Recommender. Rec4Agentverse emphasizes the collaboration between Agent Items and Agent Recommender, thereby promoting personalized information services and enhancing the exchange of information beyond the traditional user-recommender feedback loop. Additionally, we prospect the evolution of Rec4Agentverse and conceptualize it into three stages based on the enhancement of the interaction and information exchange among Agent Items, Agent Recommender, and the user. A preliminary study involving several cases of Rec4Agentverse validates its significant potential for application. Lastly, we discuss potential issues and promising directions for future research.

Outfit Recommendation (OR) in the fashion domain has evolved through two stages: Pre-defined Outfit Recommendation and Personalized Outfit Composition. However, both stages are constrained by existing fashion products, limiting their effectiveness in addressing users' diverse fashion needs. Recently, the advent of AI-generated content provides the opportunity for OR to transcend these limitations, showcasing the potential for personalized outfit generation and recommendation. To this end, we introduce a novel task called Generative Outfit Recommendation (GOR), aiming to generate a set of fashion images and compose them into a visually compatible outfit tailored to specific users. The key objectives of GOR lie in the high fidelity, compatibility, and personalization of generated outfits. To achieve these, we propose a generative outfit recommender model named DiFashion, which empowers exceptional diffusion models to accomplish the parallel generation of multiple fashion images. To ensure three objectives, we design three kinds of conditions to guide the parallel generation process and adopt Classifier-Free-Guidance to enhance the alignment between the generated images and conditions. We apply DiFashion on both personalized Fill-In-The-Blank and GOR tasks and conduct extensive experiments on iFashion and Polyvore-U datasets. The quantitative and human-involved qualitative evaluation demonstrate the superiority of DiFashion over competitive baselines., Comment: accepted for publication in SIGIR'24

Recommendation systems for Web content distribution intricately connect to the information access and exposure opportunities for vulnerable populations. The emergence of Large Language Models-based Recommendation System (LRS) may introduce additional societal challenges to recommendation systems due to the inherent biases in Large Language Models (LLMs). From the perspective of item-side fairness, there remains a lack of comprehensive investigation into the item-side fairness of LRS given the unique characteristics of LRS compared to conventional recommendation systems. To bridge this gap, this study examines the property of LRS with respect to item-side fairness and reveals the influencing factors of both historical users' interactions and inherent semantic biases of LLMs, shedding light on the need to extend conventional item-side fairness methods for LRS. Towards this goal, we develop a concise and effective framework called IFairLRS to enhance the item-side fairness of an LRS. IFairLRS covers the main stages of building an LRS with specifically adapted strategies to calibrate the recommendations of LRS. We utilize IFairLRS to fine-tune LLaMA, a representative LLM, on \textit{MovieLens} and \textit{Steam} datasets, and observe significant item-side fairness improvements. The code can be found in https://github.com/JiangM-C/IFairLRS.git., Comment: Accepted by the Proceedings of the ACM Web Conference 2024

Common click-through rate (CTR) prediction recommender models tend to exhibit feature-level bias, which leads to unfair recommendations among item groups and inaccurate recommendations for users. While existing methods address this issue by adjusting the learning of CTR models, such as through additional optimization objectives, they fail to consider how the bias is caused within these models. To address this research gap, our study performs a top-down analysis on representative CTR models. Through blocking different components of a trained CTR model one by one, we identify the key contribution of the linear component to feature-level bias. We conduct a theoretical analysis of the learning process for the weights in the linear component, revealing how group-wise properties of training data influence them. Our experimental and statistical analyses demonstrate a strong correlation between imbalanced positive sample ratios across item groups and feature-level bias. Based on this understanding, we propose a minimally invasive yet effective strategy to counteract feature-level bias in CTR models by removing the biased linear weights from trained models. Additionally, we present a linear weight adjusting strategy that requires fewer random exposure records than relevant debiasing methods. The superiority of our proposed strategies are validated through extensive experiments on three real-world datasets.

Leveraging Large Language Models (LLMs) for recommendation has recently garnered considerable attention, where fine-tuning plays a key role in LLMs' adaptation. However, the cost of fine-tuning LLMs on rapidly expanding recommendation data limits their practical application. To address this challenge, few-shot fine-tuning offers a promising approach to quickly adapt LLMs to new recommendation data. We propose the task of data pruning for efficient LLM-based recommendation, aimed at identifying representative samples tailored for LLMs' few-shot fine-tuning. While coreset selection is closely related to the proposed task, existing coreset selection methods often rely on suboptimal heuristic metrics or entail costly optimization on large-scale recommendation data. To tackle these issues, we introduce two objectives for the data pruning task in the context of LLM-based recommendation: 1) high accuracy aims to identify the influential samples that can lead to high overall performance; and 2) high efficiency underlines the low costs of the data pruning process. To pursue the two objectives, we propose a novel data pruning method based on two scores, i.e., influence score and effort score, to efficiently identify the influential samples. Particularly, the influence score is introduced to accurately estimate the influence of sample removal on the overall performance. To achieve low costs of the data pruning process, we use a small-sized surrogate model to replace LLMs to obtain the influence score. Considering the potential gap between the surrogate model and LLMs, we further propose an effort score to prioritize some hard samples specifically for LLMs. Empirical results on three real-world datasets validate the effectiveness of our proposed method. In particular, the proposed method uses only 2% samples to surpass the full data fine-tuning, reducing time costs by 97%., Comment: Accepted by SIGIR 2024

In this work, we address question answering (QA) over a hybrid of tabular and textual data that are very common content on the Web (e.g. SEC filings), where discrete reasoning capabilities are often required. Recently, large language models (LLMs) like GPT-4 have demonstrated strong multi-step reasoning capabilities. We then consider harnessing the amazing power of LLMs to solve our task. We abstract a Step-wise Pipeline for tabular and textual QA, which consists of three key steps, including Extractor, Reasoner and Executor, and initially design an instruction to instantiate the pipeline and validate that GPT-4 outperforms all existing methods. However, utilizing an online LLM like GPT-4 holds various challenges in terms of cost, latency, and data security risk, which motivates us to specialize smaller LLMs in this task. We develop a TAT-LLM language model by fine-tuning LLaMA 2 with the training data generated automatically from existing expert-annotated datasets following the Step-wise Pipeline. The experimental results have verified that our TAT-LLM model can outperform all baseline models, including the previous best fine-tuned models and very large-scale LLMs like GPT-4 on FinQA, TAT-QA and TAT-DQA benchmarks., Comment: ACL 2024 (Under Review)

Recommender systems often grapple with noisy implicit feedback. Most studies alleviate the noise issues from data cleaning perspective such as data resampling and reweighting, but they are constrained by heuristic assumptions. Another denoising avenue is from model perspective, which proactively injects noises into user-item interactions and enhances the intrinsic denoising ability of models. However, this kind of denoising process poses significant challenges to the recommender model's representation capacity to capture noise patterns. To address this issue, we propose Denoising Diffusion Recommender Model (DDRM), which leverages multi-step denoising process of diffusion models to robustify user and item embeddings from any recommender models. DDRM injects controlled Gaussian noises in the forward process and iteratively removes noises in the reverse denoising process, thereby improving embedding robustness against noisy feedback. To achieve this target, the key lies in offering appropriate guidance to steer the reverse denoising process and providing a proper starting point to start the forward-reverse process during inference. In particular, we propose a dedicated denoising module that encodes collaborative information as denoising guidance. Besides, in the inference stage, DDRM utilizes the average embeddings of users' historically liked items as the starting point rather than using pure noise since pure noise lacks personalization, which increases the difficulty of the denoising process. Extensive experiments on three datasets with three representative backend recommender models demonstrate the effectiveness of DDRM., Comment: Accepted by SIGIR 2024

Adapting Large Language Models for Recommendation (LLM4Rec) has shown promising results. However, the challenges of deploying LLM4Rec in real-world scenarios remain largely unexplored. In particular, recommender models need incremental adaptation to evolving user preferences, while the suitability of traditional incremental learning methods within LLM4Rec remains ambiguous due to the unique characteristics of Large Language Models (LLMs). In this study, we empirically evaluate two commonly employed incremental learning strategies (full retraining and fine-tuning) for LLM4Rec. Surprisingly, neither approach shows significant improvements in the performance of LLM4Rec. Instead of dismissing the role of incremental learning, we attribute the lack of anticipated performance enhancement to a mismatch between the LLM4Rec architecture and incremental learning: LLM4Rec employs a single adaptation module for learning recommendations, limiting its ability to simultaneously capture long-term and short-term user preferences in the incremental learning context. To test this speculation, we introduce a Long- and Short-term Adaptation-aware Tuning (LSAT) framework for incremental learning in LLM4Rec. Unlike the single adaptation module approach, LSAT utilizes two distinct adaptation modules to independently learn long-term and short-term user preferences. Empirical results verify that LSAT enhances performance, thereby validating our speculation. We release our code at: https://github.com/TianhaoShi2001/LSAT., Comment: accepted in the short paper track of the 2024 ACM International Conference on Information and Knowledge Management (CIKM 2024)

Short video recommendations often face limitations due to the quality of user feedback, which may not accurately depict user interests. To tackle this challenge, a new task has emerged: generating more dependable labels from original feedback. Existing label generation methods rely on manual rules, demanding substantial human effort and potentially misaligning with the desired objectives of the platform. To transcend these constraints, we introduce LabelCraft, a novel automated label generation method explicitly optimizing pivotal operational metrics for platform success. By formulating label generation as a higher-level optimization problem above recommender model optimization, LabelCraft introduces a trainable labeling model for automatic label mechanism modeling. Through meta-learning techniques, LabelCraft effectively addresses the bi-level optimization hurdle posed by the recommender and labeling models, enabling the automatic acquisition of intricate label generation mechanisms.Extensive experiments on real-world datasets corroborate LabelCraft's excellence across varied operational metrics, encompassing usage time, user engagement, and retention. Codes are available at https://github.com/baiyimeng/LabelCraft., Comment: Accepted by WSDM'24

Collaborative Filtering (CF) recommender models highly depend on user-item interactions to learn CF representations, thus falling short of recommending cold-start items. To address this issue, prior studies mainly introduce item features (e.g., thumbnails) for cold-start item recommendation. They learn a feature extractor on warm-start items to align feature representations with interactions, and then leverage the feature extractor to extract the feature representations of cold-start items for interaction prediction. Unfortunately, the features of cold-start items, especially the popular ones, tend to diverge from those of warm-start ones due to temporal feature shifts, preventing the feature extractor from accurately learning feature representations of cold-start items. To alleviate the impact of temporal feature shifts, we consider using Distributionally Robust Optimization (DRO) to enhance the generation ability of the feature extractor. Nonetheless, existing DRO methods face an inconsistency issue: the worse-case warm-start items emphasized during DRO training might not align well with the cold-start item distribution. To capture the temporal feature shifts and combat this inconsistency issue, we propose a novel temporal DRO with new optimization objectives, namely, 1) to integrate a worst-case factor to improve the worst-case performance, and 2) to devise a shifting factor to capture the shifting trend of item features and enhance the optimization of the potentially popular groups in cold-start items. Substantial experiments on three real-world datasets validate the superiority of our temporal DRO in enhancing the generalization ability of cold-start recommender models. The code is available at https://github.com/Linxyhaha/TDRO/., Comment: Accepted by AAAI'24

Fine-tuning pre-trained language models (LMs) has become the de facto standard in many NLP tasks. Nevertheless, fine-tuned LMs are still prone to robustness issues, such as adversarial robustness and model calibration. Several perspectives of robustness for LMs have been studied independently, but lacking a unified consideration in multiple perspectives. In this paper, we propose Robustifying LMs via Adversarial perturbation with Selective Training (RoAST), a simple yet effective fine-tuning technique to enhance the multi-perspective robustness of LMs in a unified way. RoAST effectively incorporates two important sources for the model robustness, robustness on the perturbed inputs and generalizable knowledge in pre-trained LMs. To be specific, RoAST introduces adversarial perturbation during fine-tuning while the model parameters are selectively updated upon their relative importance to minimize unnecessary deviation. Under a unified evaluation of fine-tuned LMs by incorporating four representative perspectives of model robustness, we demonstrate the effectiveness of RoAST compared to state-of-the-art fine-tuning methods on six different types of LMs, which indicates its usefulness in practice., Comment: 33 pages, accepted at EMNLP 2023 Findings

Leveraging Large Language Models as Recommenders (LLMRec) has gained significant attention and introduced fresh perspectives in user preference modeling. Existing LLMRec approaches prioritize text semantics, usually neglecting the valuable collaborative information from user-item interactions in recommendations. While these text-emphasizing approaches excel in cold-start scenarios, they may yield sub-optimal performance in warm-start situations. In pursuit of superior recommendations for both cold and warm start scenarios, we introduce CoLLM, an innovative LLMRec methodology that seamlessly incorporates collaborative information into LLMs for recommendation. CoLLM captures collaborative information through an external traditional model and maps it to the input token embedding space of LLM, forming collaborative embeddings for LLM usage. Through this external integration of collaborative information, CoLLM ensures effective modeling of collaborative information without modifying the LLM itself, providing the flexibility to employ various collaborative information modeling techniques. Extensive experiments validate that CoLLM adeptly integrates collaborative information into LLMs, resulting in enhanced recommendation performance. We release the code and data at https://github.com/zyang1580/CoLLM.

Large language models (LLMs) are susceptible to red teaming attacks, which can induce LLMs to generate harmful content. Previous research constructs attack prompts via manual or automatic methods, which have their own limitations on construction cost and quality. To address these issues, we propose an integrated approach that combines manual and automatic methods to economically generate high-quality attack prompts. Specifically, considering the impressive capabilities of newly emerged LLMs, we propose an attack framework to instruct LLMs to mimic human-generated prompts through in-context learning. Furthermore, we propose a defense framework that fine-tunes victim LLMs through iterative interactions with the attack framework to enhance their safety against red teaming attacks. Extensive experiments on different LLMs validate the effectiveness of our proposed attack and defense frameworks. Additionally, we release a series of attack prompts datasets named SAP with varying sizes, facilitating the safety evaluation and enhancement of more LLMs. Our code and dataset is available on https://github.com/Aatrox103/SAP ., Comment: Accepted to EMNLP 2023 (Findings)

Harnessing Large Language Models (LLMs) for recommendation is rapidly emerging, which relies on two fundamental steps to bridge the recommendation item space and the language space: 1) item indexing utilizes identifiers to represent items in the language space, and 2) generation grounding associates LLMs' generated token sequences to in-corpus items. However, previous methods exhibit inherent limitations in the two steps. Existing ID-based identifiers (e.g., numeric IDs) and description-based identifiers (e.g., titles) either lose semantics or lack adequate distinctiveness. Moreover, prior generation grounding methods might generate invalid identifiers, thus misaligning with in-corpus items. To address these issues, we propose a novel Transition paradigm for LLM-based Recommender (named TransRec) to bridge items and language. Specifically, TransRec presents multi-facet identifiers, which simultaneously incorporate ID, title, and attribute for item indexing to pursue both distinctiveness and semantics. Additionally, we introduce a specialized data structure for TransRec to ensure generating valid identifiers only and utilize substring indexing to encourage LLMs to generate from any position of identifiers. Lastly, TransRec presents an aggregated grounding module to leverage generated multi-facet identifiers to rank in-corpus items efficiently. We instantiate TransRec on two backbone models, BART-large and LLaMA-7B. Extensive results on three real-world datasets under diverse settings validate the superiority of TransRec., Comment: Accepted by KDD 2024

In recent years, recommender systems have become a ubiquitous part of our daily lives, while they suffer from a high risk of being attacked due to the growing commercial and social values. Despite significant research progress in recommender attack and defense, there is a lack of a widely-recognized benchmarking standard in the field, leading to unfair performance comparison and limited credibility of experiments. To address this, we propose RecAD, a unified library aiming at establishing an open benchmark for recommender attack and defense. RecAD takes an initial step to set up a unified benchmarking pipeline for reproducible research by integrating diverse datasets, standard source codes, hyper-parameter settings, running logs, attack knowledge, attack budget, and evaluation results. The benchmark is designed to be comprehensive and sustainable, covering both attack, defense, and evaluation tasks, enabling more researchers to easily follow and contribute to this promising field. RecAD will drive more solid and reproducible research on recommender systems attack and defense, reduce the redundant efforts of researchers, and ultimately increase the credibility and practical value of recommender attack and defense. The project is released at https://github.com/gusye1234/recad.

Learning from corrupted labels is very common in real-world machine-learning applications. Memorizing such noisy labels could affect the learning of the model, leading to sub-optimal performances. In this work, we propose a novel framework to learn robust machine-learning models from noisy labels. Through an empirical study, we find that different models make relatively similar predictions on clean examples, while the predictions on noisy examples vary much more across different models. Motivated by this observation, we propose \em denoising with cross-model agreement \em (DeCA) which aims to minimize the KL-divergence between the true label distributions parameterized by two machine learning models while maximizing the likelihood of data observation. We employ the proposed DeCA on both the binary label scenario and the multiple label scenario. For the binary label scenario, we select implicit feedback recommendation as the downstream task and conduct experiments with four state-of-the-art recommendation models on four datasets. For the multiple-label scenario, the downstream application is image classification on two benchmark datasets. Experimental results demonstrate that the proposed methods significantly improve the model performance compared with normal training and other denoising methods on both binary and multiple-label scenarios., Comment: arXiv admin note: substantial text overlap with arXiv:2105.09605

As the focus on Large Language Models (LLMs) in the field of recommendation intensifies, the optimization of LLMs for recommendation purposes (referred to as LLM4Rec) assumes a crucial role in augmenting their effectiveness in providing recommendations. However, existing approaches for LLM4Rec often assess performance using restricted sets of candidates, which may not accurately reflect the models' overall ranking capabilities. In this paper, our objective is to investigate the comprehensive ranking capacity of LLMs and propose a two-step grounding framework known as BIGRec (Bi-step Grounding Paradigm for Recommendation). It initially grounds LLMs to the recommendation space by fine-tuning them to generate meaningful tokens for items and subsequently identifies appropriate actual items that correspond to the generated tokens. By conducting extensive experiments on two datasets, we substantiate the superior performance, capacity for handling few-shot scenarios, and versatility across multiple domains exhibited by BIGRec. Furthermore, we observe that the marginal benefits derived from increasing the quantity of training samples are modest for BIGRec, implying that LLMs possess the limited capability to assimilate statistical information, such as popularity and collaborative filtering, due to their robust semantic priors. These findings also underline the efficacy of integrating diverse statistical information into the LLM4Rec framework, thereby pointing towards a potential avenue for future research. Our code and data are available at https://github.com/SAI990323/Grounding4Rec., Comment: 17 pages

Adverse drug reaction (ADR) prediction plays a crucial role in both health care and drug discovery for reducing patient mortality and enhancing drug safety. Recently, many studies have been devoted to effectively predict the drug-ADRs incidence rates. However, these methods either did not effectively utilize non-clinical data, i.e., physical, chemical, and biological information about the drug, or did little to establish a link between content-based and pure collaborative filtering during the training phase. In this paper, we first formulate the prediction of multi-label ADRs as a drug-ADR collaborative filtering problem, and to the best of our knowledge, this is the first work to provide extensive benchmark results of previous collaborative filtering methods on two large publicly available clinical datasets. Then, by exploiting the easy accessible drug characteristics from non-clinical data, we propose ADRNet, a generalized collaborative filtering framework combining clinical and non-clinical data for drug-ADR prediction. Specifically, ADRNet has a shallow collaborative filtering module and a deep drug representation module, which can exploit the high-dimensional drug descriptors to further guide the learning of low-dimensional ADR latent embeddings, which incorporates both the benefits of collaborative filtering and representation learning. Extensive experiments are conducted on two publicly available real-world drug-ADR clinical datasets and two non-clinical datasets to demonstrate the accuracy and efficiency of the proposed ADRNet. The code is available at https://github.com/haoxuanli-pku/ADRnet., Comment: RecSys '23