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ABSTRACTBackground California school nurses have cited a lack of training as an obstacle to conducting dental screenings. The objectives of this pilot project were to develop educational materials, train school nurses to perform basic dental screening examinations, and evaluate the acceptability and perceived effectiveness of the training program.Methods A two-part training program (synchronous webinar followed by practical session) to train school nurses from Santa Rosa City Schools, California, for conducting basic screening surveys was developed during the COVID-19 pandemic. This was a mixed methods study.Results At baseline, half of the nurses did not feel confident in performing dental screening (10-point Likert scale scores ranged from 2 to 4). After the training, the nurses reported enjoying the training program as well as an improvement in their knowledge and increase in confidence to 1) screen children’s mouths, 2) identify decayed teeth that need treatment, 3) triage oral health care needs appropriately, and 4) refer children to a dentist (average Likert scale scores of 7–8).Conclusions The training program was acceptable to school nurses and increased their perceived capacity to perform school dental screening. This study shows that by training and educating school nurses, it is possible to build their capacity up to the point where they are empowered to confidently perform basic dental screenings.Practical Implications School-based dental programs should consider partnering with school nurses to screen for children with dental needs. This study adds to the literature on inter-sectoral collaborations and team-based partnerships to improve oral health.

A low-noise Low Dropout Regulator (LDO) is designed in a Semiconductor Manufacturing International Corporation (SMIC) $0.18~\mu $ m process, aiming at supply of a clean and constant clamping voltage in the operation of Correlated Double Sampling (CDS) for elimination of switching and reset noise in CMOS Pixel Sensors (CPS) applied to high energy physics experiments. In order to decrease noise of the LDO, a noise model of the LDO consisting of blocks, such as a pass transistor, a resistor network, and an error amplifier, is constructed and noise contributions made by these blocks are analyzed in detail. According to results of the noise analysis, the error amplifier is identified as the major noise source. For the purpose of reduction in noise, especially 1/f noise, an error amplifier exploiting a chopper stabilization technique is proposed. Simulation results demonstrate the effectiveness of the proposed method. The Power Spectral Density (PSD) of the LDO’s output noise is only 60 nV/ $\surd $ Hz at 10 Hz and total integrated noise within the bandwidth is $40~\mu $ V.

Microfibrillar-associated protein 2 (MFAP2) is a small glycoprotein that is involved in vascular development and metabolic disease. The present study aims to explore the regulatory role of MFAP2 in the development and progression of oral squamous cell carcinoma (OSCC), including the underlying mechanisms. MFAP2 expression and its association with the progression of OSCC are explored using bioinformatics. MFAP2 expression in OSCC tissues is detected by immunohistochemical staining. SCC15 cell migration, invasion, apoptosis, proliferation, and viability are detected by wound healing, Transwell, flow cytometry, colony formation, and cell counting kit-8 assays. An in vivo experiment is used to detect tumor formation. Western blot analysis is used to determine MFAP2’s regulatory role in autophagy and the Wnt/β-catenin signaling pathway. MFAP2 is highly expressed in SCC15 cells and OSCC tissues, which correlates positively with the poor prognosis of patients with OSCCs. Functionally, MFAP2 promotes oncogenic autophagy to increase cell invasion, migration, and proliferation but inhibits apoptosis in SCC15 cells and promotes tumor growth in vivo. Mechanistically, MFAP2 upregulates autophagy and Wnt/β-catenin signaling to stimulate OSCC development. Intriguingly, regulation of Wnt/β-catenin signaling dependent on autophagy contributes to the malignant behaviors of SCC15 cells. MFAP2 could serve as a novel biomarker for OSCC and could affect OSCC tumorigenesis and development via autophagic regulation of Wnt/β-catenin signaling.

Introduction: This work investigates the compatibility of integrated care and competition in China and analyses the impact of integrated care on regional care quality (DeptQ) within a competitive framework. Method: The study was built on multivariate correspondence analysis and a two-way fixed-effects model. The data were collected from Xiamen's Big Data Application Open Platform and represent nine specialised departments that regularly performed inter-institutional referrals between 2016 and 2019. Results: First, care quality for referred patients (ReferQ) and the relative scale of referred patients (ReferScale) and competition have an antagonistic but not completely mutually exclusive relationship. Second, ReferQ and competition both have a significant effect on DeptQ, but only when competition is weak can ReferQ and competition act synergistically on DeptQ. When competition is fierce, competition will weaken the impact of ReferQ on DeptQ. Conclusion: Changes in the intensity of integrated care and competition ultimately affect care quality.

The transition towards renewable energy sources necessitates efficient energy storage systems to meet growing demands. Electrochemical capacitors, particularly electric double-layer capacitors (EDLCs), show promising performance due to their superior properties. However, the presence of resistance limits their performance. This study explores using an external magnetic field to mitigate ion transfer resistance and enhance capacitance in magnetite-reduced graphene oxide (M-rGO) nanocomposites. M-rGO nanocomposites with varying weight ratios of magnetite were synthesized and comprehensively characterized. Characterization highlighted the difference in certain parameters such as C/O ratio, the Id/Ig ratio, surface area and particle size that contribute towards alteration of M-rGO's capacitive behaviour. Electrochemical studies demonstrated that applying a magnetic field increased specific capacitance by approximately 20% and reduced resistance by 33%. Notably, a maximum specific capacitance of 16.36 F/g (at a scan rate of 0.1 V/s) and 27.24 F/g (at a current density of 0.25 A/g) was achieved. These improvements were attributed to enhanced ion transportation and migration at the electrode/electrolyte interface, lowering overall resistance. However, it was also observed that the aforementioned parameters can also limit the M-rGO's performance, resulting in saturated capacitive state despite a reduced resistance. The integration of magnetic fields enhances energy storage in nanocomposite systems, necessitating further investigation into underlying mechanisms and practical applications.

Introduction: The burden of cognitive impairment in heart failure (HF) patients is significant and leads to longer hospital stay, higher readmission rates, and increased mortality. This review seeks to synthesize the available studies to determine the prevalence and incidence of cognitive impairment and dementia in HF patients. Methods: PubMed, Embase, PsychoINFO, and Cochrane databases were systematically searched from their inception through to May 3, 2021. Study and population characteristics, total patients with HF, prevalence of cognitive impairment and dementia in HF patients, and cognitive assessment tool were abstracted by two reviewers. Results: In HF patients, the overall prevalence for cognitive impairment and dementia was 41.42% (CI) and 19.79% (dementia), respectively. We performed a meta-regression analysis, which demonstrated that the risk of cognitive impairment and dementia increased with age. Discussion: Further research should investigate whether HF accelerates the rate of cognitive decline and the progression of dementia.

There is no doubt that organic dyes currently play an indispensable role in our daily life; they are used in products such as furniture, textiles, and leather accessories. However, the main problems related to the widespread use of these dyes are their toxicity and non-biodegradable nature, which mainly are responsible for various environmental risks and threaten human life. Therefore, the elimination of these toxic materials from aqueous media is highly recommended to save freshwater resources, as well as our health and environment. Heterogeneous photocatalysis is a potential technique for dye degradation, in which a photocatalyst is used to absorb light (UV or visible) and produce electron–hole pairs that enable the reaction participants to undergo chemical changes. In the past, various metal oxides have been successfully applied as promising photocatalysts for the degradation of dyes and various organic pollutants due to their wide bandgap, optical, and electronic properties, in addition to their low cost, high abundance, and chemical stability in aqueous solutions. Various parameters play critical roles in the total performance of the photocatalyst during the photocatalytic degradation of dyes, including morphology, which is a critical factor in the overall degradation process. In our article, the recent progress on the morphological dependence of photocatalysts will be reviewed.

ObjectivePrior studies have shown that plaque inflammation on FDG-PET and the symptomatic carotid atheroma inflammation lumen-stenosis (SCAIL) score were associated with recurrent ischemic events, but the findings have thus far not been widely validated. Therefore, we aimed to validate the findings of prior studies.MethodsA single-center prospective cohort study that recruited patients with (1) recent TIA or ischemic stroke within the past 30 days, (2) ipsilateral carotid artery stenosis of ≥50%, and (3) were not considered for early carotid revascularization. The (1) maximum standardized uptake value (SUVmax) of the symptomatic carotid plaque, (2) the SCAIL score, and (3) stenosis severity of the symptomatic carotid artery were measured for all patients. The outcomes were (1) a 90-day ipsilateral ischemic stroke and (2) a 90-day ipsilateral symptomatic TIA or major adverse cardiovascular event (MACE).ResultsAmong the 131 patients included in the study, the commonest cardiovascular risk factor was hypertension (95 patients, 72.5%), followed by diabetes mellitus (77 patients, 58.8%) and being a current smoker (64 patients, 48.9%). The median (IQR) duration between the index cerebral ischemic event and recruitment to the study was 1 (0, 2.5) days. The median (IQR) duration between the index cerebral ischemic event and FDG-PET was 5 (4, 7) days. A total of 14 (10.7%) patients had a 90-day stroke, and 41 (31.3%) patients had a 90-day TIA or MACE. On comparison of the predictive performances of the SCAIL score and SUVmax, SUVmax was found to be superior to the SCAIL score for predicting both 90-day ipsilateral ischemic stroke (AUC: SCAIL = 0.79, SUVmax = 0.92; p < 0.001; 95% CI = 0.072, 0.229) and 90-day TIA or MACE (AUC: SCAIL = 0.76, SUVmax = 0.84; p = 0.009; 95% CI = 0.020, 0.143).ConclusionPlaque inflammation as quantified on FDG-PET may serve as a reliable biomarker for risk stratification among patients with ECAD and recent TIA or ischemic stroke. Future studies should evaluate whether patients with significant plaque inflammation as quantified on FDG-PET benefit from carotid revascularization and/or anti-inflammatory therapy.