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1. Contents Vol. 7, 2007

Author

Maxim S. Petrov, Alexander S. Gordetzov, J. A. Murphy, György M. Buzás, Timothy A. Woodward, Werner Van Steenbergen, Ru F. Chen, H. Oettle, Valerio Di Carlo, Zhi H. Li, Osman Yüksel, Quan B. Zhou, H. Riess, Eduardo Moreno-Osset, Marco Del Chiaro, Lorenzo Fantini, Gwen Lomberk, John A. Dumot, Daniel H. Palmer, Maria A. Caligo, Michelle A. Anderson, Fen Y. Yu, Mark J. Truty, Massimo Falconi, Silvano Presciuttini, Gulsen Yilmaz, David N. Criddle, Roberto Salvia, Ömer Başar, Fernando Gómez, Antonio López, Giorgio Casari, Emre Yıldırım, Jia J. Zhou, Maria Schipper, R.K. Vasishta, Martin E. Fernandez-Zapico, Mansour A. Parsi, María Jesús Martínez, R. Sopena, Pankaj Jain, Robert Sutton, J.D. Wig, Daniel D. Billadeau, Surakit Pungpapong, Jie Wang, Raffaele Pezzilli, P. Neuhaus, Alvaro Pascual-Leone, Euan McLaughlin, Hein G. Gooszen, S.K. Arora, Ji S. Chen, Steven D. Freedman, James M. Scheiman, J. Krysa, Karel J. van Erpecum, Mehmet Ibis, L. Bertacca, Laura Seynaeve, Qi B. Tang, Alessandro Zerbi, Raul Urrutia, Franco Mosca, Madhusudhan R. Sanaka, Nora Sartori, Kyung W. Noh, Paolo Pederzoli, Ricardo A. Cruciani, A. Steger, Ole H. Petersen, S. Majumdar, Leticia de la Cueva, Mikhail V. Kukosh, Fatma Meric Yilmaz, Zeynel Abidin Öztürk, Felipe Fregni, Antonio Maria Morselli-Labate, Philip R. Fischer, D.K. Bakshi, Tomás Ripollés, L. Singh, Biancamaria Longoni, Marco Polese, Matthew J. DiMagno, Erik Buskens, Ugo Boggi, Joel H. Rubenstein, Annemarie C. de Vries, Sandeep Nijhawan, Massimo Raimondo, Seyfettin Köklü, Qiu H. Pan, Marc G. Besselink, Michael B. Wallace, Mohammad A. Al-Haddad, and Ben U. Ridwan

Subjects
Hepatology, Traditional medicine, business.industry, Endocrinology, Diabetes and Metabolism, Gastroenterology, Medicine, business
Published
2007
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2. In vivo Radioiodide Imaging and Treatment of Pancreatic Cancer Xenografts after MUC1 Promoter-Driven Expression of the Human Sodium-Iodide Symporter

Author

Qiu H. Pan, Zhi H. Li, Fen Y. Yu, Quan B. Zhou, Jie Wang, Ru F. Chen, Qi B. Tang, Jia J. Zhou, and Ji S. Chen

Subjects
Sodium-iodide symporter, Endocrinology, Diabetes and Metabolism, Molecular Sequence Data, Fluorescent Antibody Technique, Mice, Nude, Iodine Radioisotopes, Mice, In vivo, Cell Line, Tumor, Pancreatic cancer, Animals, Humans, Medicine, Promoter Regions, Genetic, skin and connective tissue diseases, MUC1, Base Sequence, Symporters, Hepatology, business.industry, Mucin-1, Gastroenterology, Iodides, medicine.disease, Xenograft Model Antitumor Assays, Pancreatic Neoplasms, Symporter, Cancer research, Female, CA19-9, Tumor-associated glycoprotein 72, business, Ovarian cancer, HeLa Cells
Abstract

Mucin 1 (MUC1) is a transmembrane glycoprotein that is overexpressed in many tumor types, including breast, pancreatic, and ovarian cancer. The aim of this study was to create a construct containing sodium-iodide symporter (NIS) under the control of the 0.8-kb MUC1 promoter to infect pancreatic cancer cells both in vitro and in vivo, to investigate the potential for radioiodide imaging and ablation of this disease.We amplified the 797-bp MUC1 promoter by two-step nested PCR. Subsequently, a replication-deficient adenoviral construct was created containing the MUC1 promoter followed by the human NIS gene. Iodide uptake assays and immunofluorescence were used to confirm NIS expression and function. Pancreatic cancer xenografts in mice were infected with Ad/MUC1/NIS and then imaged and treated using radioiodide.A 23- and 15.5-fold increase in iodide uptake was observed in Ad/MUC1/NIS-infected MUC1-positive Capan-2 and SW1990 cells with no significant increase observed in MUC1-negative Hela cells or in cells infected with the control virus. The in vivo study showed a clear image of Ad/MUC1/NIS-infected tumor xenografts using (125)I. Administration of a therapeutic dose of (131)I resulted in a regression in size to 76 +/- 15% of their original volume, whereas control tumors continued to increase in size to200% of their original volume.These results show that the 0.8-kb MUC1 promoter was successfully used to drive human NIS-targeted expression in pancreatic cancer cells, and Ad/MUC1/NIS-mediated radiotherapy can make pancreatic cancer xenografts in mice shrinking. This could potentially have applications for both imaging and therapy in other MUC1-positive tumors.

Published
2007
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3. Subject Index Vol. 7, 2007

Author

R.K. Vasishta, L. Bertacca, Daniel H. Palmer, Maria A. Caligo, Jie Wang, Alessandro Zerbi, Martin E. Fernandez-Zapico, Marco Del Chiaro, Hein G. Gooszen, David N. Criddle, Nora Sartori, Roberto Salvia, Fen Y. Yu, Gwen Lomberk, Giorgio Casari, Gulsen Yilmaz, Leticia de la Cueva, Philip R. Fischer, Valerio Di Carlo, Laura Seynaeve, James M. Scheiman, Osman Yüksel, Quan B. Zhou, H. Riess, John A. Dumot, Michelle A. Anderson, Daniel D. Billadeau, Timothy A. Woodward, H. Oettle, P. Neuhaus, Raffaele Pezzilli, Raul Urrutia, Kyung W. Noh, Ömer Başar, Silvano Presciuttini, Massimo Falconi, María Jesús Martínez, Fernando Gómez, Alexander S. Gordetzov, Franco Mosca, Marc G. Besselink, Jia J. Zhou, Marco Polese, Mehmet Ibis, Ji S. Chen, J. Krysa, Steven D. Freedman, Fatma Meric Yilmaz, Sandeep Nijhawan, Massimo Raimondo, R. Sopena, Euan McLaughlin, Qi B. Tang, Maxim S. Petrov, Ole H. Petersen, Matthew J. DiMagno, Eduardo Moreno-Osset, Lorenzo Fantini, D.K. Bakshi, A. Steger, Mikhail V. Kukosh, Paolo Pederzoli, J. A. Murphy, Zeynel Abidin Öztürk, Tomás Ripollés, L. Singh, S. Majumdar, Werner Van Steenbergen, Mark J. Truty, Felipe Fregni, Seyfettin Köklü, Ru F. Chen, Joel H. Rubenstein, Ricardo A. Cruciani, Surakit Pungpapong, Qiu H. Pan, Michael B. Wallace, Annemarie C. de Vries, Maria Schipper, Biancamaria Longoni, Mohammad A. Al-Haddad, György M. Buzás, Zhi H. Li, S.K. Arora, Ben U. Ridwan, Pankaj Jain, Robert Sutton, J.D. Wig, Alvaro Pascual-Leone, Karel J. van Erpecum, Erik Buskens, Ugo Boggi, Antonio López, Emre Yıldırım, Mansour A. Parsi, Madhusudhan R. Sanaka, and Antonio Maria Morselli-Labate

Subjects
Index (economics), Hepatology, business.industry, Endocrinology, Diabetes and Metabolism, Statistics, Gastroenterology, Medicine, Subject (documents), business
Published
2007
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