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269 results on '"Femat, R."'

11. Artificial Neural Network-Based Serum Biomarkers Analysis Improves Sensitivity in the Diagnosis of Lung Cancer

Author

Flores, J. M., Herrera, E., Leal, G., González, M. G., Sánchez, F., Rojas, A., Cabrera, P. A., Femat, R., Martínez-Velázquez, M., Folgueras Méndez, José, editor, Aznielle Rodríguez, Tania Y., editor, Calderón Marín, Carlos F., editor, Llanusa Ruiz, Susana Beatriz, editor, Castro Medina, Jorge, editor, Vega Vázquez, Haddid, editor, Carballo Barreda, Maylen, editor, and Rodríguez Rojas, Rafael, editor

Published
2013
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36. Fuzzy-based controller for glucose regulation in type-1 diabetic patients by subcutaneous route

Author

Campos-Delgado, D.U., Hernandez-Ordonez, M., Femat, R., and Gordillo-Moscoso, A.

Subjects
Diabetes -- Research, Fuzzy algorithms -- Analysis, Fuzzy logic -- Analysis, Fuzzy systems -- Analysis, Dextrose -- Research, Dextrose -- Physiological aspects, Glucose -- Research, Glucose -- Physiological aspects, Fuzzy logic, Biological sciences, Business, Computers, Health care industry
Abstract

This paper presents an advisory/control algorithm for a type-1 diabetes mellitus (TIDM) patient under an intensive insulin treatment based on a multiple daily injections regimen (MDIR). The advisory/control algorithm incorporates expert knowledge about the treatment of this disease by using Mamdani-type fuzzy logic controllers to regulate the blood glucose level (BGL). The overall control strategy is based on a two-loop feedback strategy to overcome the variability in the glucose-insulin dynamics from patient to patient. An inner-loop provides the amount of both rapid/short and intermediate/long acting insulin (RSAI and ILAI) formulations that are programmed in a three-shots daily basis before meals. The combined preparation is then injected by the patient through a subcutaneous route. Meanwhile, an outer-loop adjusts the maximum amounts of insulin provided to the patient in a time-scale of days. The outer-loop controller aims to work as a supervisor of the inner-loop controller. Extensive closed-loop simulations are illustrated, using a detailed compartmental model of the insulin-glucose dynamics in a TIDM patient with meal intake. Index Terms--Diabetes mellitus, fuzzy control, glucose regulation, intensive insulin therapy.

Published
2006

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