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8. Dopamine D2 receptor gene polymorphisms in newborn infants of drug-using women

Author

Oei, Ju Lee, Xu, H. X., ABDEL-LATIF, Mohamed E., Vunnam, K., Al-Amry, A., Clews, S., Falconer, J., Feller, J. M., Lui, K., Oei, Ju Lee, Xu, H. X., ABDEL-LATIF, Mohamed E., Vunnam, K., Al-Amry, A., Clews, S., Falconer, J., Feller, J. M., and Lui, K.

Abstract

OBJECTIVES To determine the characteristics of dopamine D2 receptor gene (DRD2) polymorphisms in drug-exposed and unexposed neonates and the relationship to neonatal abstinence syndrome (NAS). DESIGN Retrospective case-control analysis between drug-exposed and unexposed infants between DRD2 polymorphisms, drug exposure and NAS treatment. PATIENTS Drug-exposed (n=48) and drug-free (n=49) infants born between March 1999 and December 2006. METHODS Analysis of DNA for the Taq1A, -141Ins/Del and Ser311Cys DRD2 polymorphisms. Drug exposure was determined by antenatal maternal drug and alcohol history. Frequency measures of DRD2 polymorphisms were compared between drug-exposed infants, treatment NAS medication and with control infants. SETTING Tertiary maternity hospital, Sydney, Australia. MAIN OUTCOME MEASURES All infants were born in a good condition (25.7% <37 weeks gestation). Opiates (methadone and heroin) were used by 45 (93.8%) of drug-exposed mothers. The A2A2 allele was more common in drug-exposed infants (37 (77.0%) versus 23 (46.9%), p=0.003) but the A1A2 allele was more common in control infants (23 (46.9%) versus 4 (8.3%), p=0.00002). The-ins allele was more common in control (39 (79.6%) versus 20 (41.7%), p=<0.01) and unmedicated drug-exposed (14/25 (56%) versus 5/23 (21.7%), p=0.02) infants. The majority of infants (41 (83.7%) controls versus 41 (85.4%), p=1.000) expressed the least common, Ser polymorphism. CONCLUSIONS DRD2 polymorphisms are detectable from DNA obtained from stored blood spots. The -ins allele is more common in control and unmedicated drug-exposed infants. Further study is recommended to explore postneonatal outcomes especially in relation to neuropsychiatric behaviours.

Published
2011

9. Coordinated outpatient care of the narcotic-dependent infant.

Author

Oei, Julee, Oei, J, Feller, JM, Lui, K, and Feller, J M

Subjects
TREATMENT of drug withdrawal symptoms, INFANT care, PEDIATRICS, THERAPEUTIC use of narcotics, METHADONE treatment programs, LENGTH of stay in hospitals, SUBSTANCE abuse, OUTPATIENT medical care, NEONATAL diseases, RETROSPECTIVE studies, PRENATAL exposure delayed effects, CHILD health services, PREGNANCY complications, DISEASE complications
Abstract

Objective: Concern regarding parental capacity to manage their infant's drug withdrawal traditionally leads to prolonged hospitalization for both mother and infant. This study examines the impact of a multidisciplinary follow-up clinic for infants discharged home on morphine.Methodology: Records of full-term infants born to mothers with narcotic dependency were reviewed retrospectively. Two periods were compared: 1995-1997 (period A) and 1998 to September 1999 with clinic established (period B).Results: Twenty-five and 26 mothers were identified in periods A and B, respectively. Almost half had fewer than four antenatal clinic visits and most were on methadone with other substance usage. Despite higher maternal methadone doses (mean 48.5 vs 89.5 mg/day, P = 0.009) and withdrawal rates, the mean length of stay was significantly shorter for period B mothers (7.8 +/- 4.8 vs 5.4 +/- 3.3 days, P = 0.01) and babies (14.8 +/- 9.7 vs 8.7 +/- 7.2, P = 0.01). Median duration of morphine treatment was significantly shorter in period A (17 vs 60 days, P = 0.0001) when only four babies were discharged on morphine. In contrast, 18 treated period B babies were discharged on morphine. No families were lost to follow up. Compliance with clinic attendance was 92%.Conclusions: Hospital stay was reduced with establishment of the clinic. The shorter treatment duration before establishment of the clinic could have been related to a lesser abstinence severity or a perceived need of a more rapid weaning prior to discharge. Further studies are needed to assess the impact of this model of care on the health outcome of the narcotic-dependent mother and infant unit. [ABSTRACT FROM AUTHOR]

Published
2001
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11. Inclusive Baryon Production ine+e−Annihilation

Author

Piccolo, M., primary, Peruzzi, I., additional, Lüke, D., additional, Lüth, V., additional, Richter, B., additional, Abrams, G. S., additional, Alam, M. S., additional, Barbaro-Galtieri, A., additional, Boyarski, A. M., additional, Breidenbach, M., additional, Chinowsky, W., additional, Dorfan, J. M., additional, Ely, R., additional, Feldman, G. J., additional, Feller, J. M., additional, Fong, A., additional, Gobbi, B., additional, Goldhaber, G., additional, Hanson, G., additional, Jaros, J. A., additional, Johnson, A. D., additional, Kadyk, J. A., additional, Kwan, B. P., additional, Larsen, R. R., additional, LeComte, P., additional, Litke, A. M., additional, Lynch, H., additional, Madaras, R. J., additional, Martin, J. F., additional, Miller, D. H., additional, Nguyen, H. K., additional, Parker, S. I., additional, Paterson, J. M., additional, Perl, M. L., additional, Pun, T. P., additional, Rapidis, P. A., additional, Ronan, M. T., additional, Ross, R. R., additional, Scharre, D. L., additional, Schwitters, R. F., additional, Tanenbaum, W., additional, Trippe, T. G., additional, Trilling, G. H., additional, Vuillemin, V., additional, Wiss, J. E., additional, and Yount, D. E., additional

Published
1977
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12. Observation ofμ3πEvents ine+e−Annihilation

Author

Jaros, J. A., primary, Abrams, G. S., additional, Alam, M. S., additional, Barbaro-Galtieri, A., additional, Boyarski, A. M., additional, Breidenbach, M., additional, Chinowsky, W., additional, Dorfan, J. M., additional, Ely, R., additional, Feldman, G. J., additional, Feller, J. M., additional, Fong, A., additional, Gobbi, B., additional, Goldhaber, G., additional, Hanson, G., additional, Johnson, A. D., additional, Kadyk, J. A., additional, Kwan, B. P., additional, Lecomte, P., additional, Litke, A., additional, Lüke, D., additional, Lüth, V., additional, Madaras, R. J., additional, Martin, J. F., additional, Miller, D. H., additional, Nguyen, H. K., additional, Parker, S. I., additional, Paterson, J. M., additional, Perl, M. L., additional, Peruzzi, I., additional, Piccolo, M., additional, Pun, T. P., additional, Rapidis, P. A., additional, Ronan, M. T., additional, Ross, R. R., additional, Scharre, D. L., additional, Schwitters, R. F., additional, Tanenbaum, W., additional, Trippe, T. G., additional, Trilling, G. H., additional, Vuillemin, V., additional, and Yount, D. E., additional

Published
1978
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13. Study ofDMesons Produced in the Decay of theψ(3772)

Author

Peruzzi, I., primary, Piccolo, M., additional, Feldman, G. J., additional, Lecomte, P., additional, Vuillemin, V., additional, Barbaro-Galtieri, A., additional, Dorfan, J. M., additional, Ely, R., additional, Feller, J. M., additional, Fong, A., additional, Gobbi, B., additional, Hanson, G., additional, Jaros, J. A., additional, Kwan, B. P., additional, Litke, A. M., additional, Lüke, D., additional, Madaras, R. J., additional, Martin, J. F., additional, Miller, D. H., additional, Parker, S. I., additional, Perl, M. L., additional, Pun, T. P., additional, Rapidis, P. A., additional, Ronan, M. T., additional, Ross, R. R., additional, Scharre, D. L., additional, Trippe, T. G., additional, and Yount, D. E., additional

Published
1977
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14. Observation of a Resonance ine+e−Annihilation Just above Charm Threshold

Author

Rapidis, P. A., primary, Gobbi, B., additional, Lüke, D., additional, Barbaro-Galtieri, A., additional, Dorfan, J. M., additional, Ely, R., additional, Feldman, G. J., additional, Feller, J. M., additional, Fong, A., additional, Hanson, G., additional, Jaros, J. A., additional, Kwan, B. P., additional, Lecomte, P., additional, Litke, A. M., additional, Madaras, R. J., additional, Martin, J. F., additional, Mast, T. S., additional, Miller, D. H., additional, Parker, S. I., additional, Perl, M. L., additional, Peruzzi, I., additional, Piccolo, M., additional, Pun, T. P., additional, Ronan, M. T., additional, Ross, R. R., additional, Sadoulet, B., additional, Trippe, T. G., additional, Vuillemin, V., additional, and Yount, D. E., additional

Published
1977
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15. Inclusive Studies ofD-Meson Decays at theψ(3772)

Author

Vuillemin, V., primary, Feldman, G. J., additional, Feller, J. M., additional, Fong, A., additional, Barbaro-Galtieri, A., additional, Ely, R., additional, Gobbi, B., additional, Hanson, G., additional, Jaros, J. A., additional, Kwan, B. P., additional, Lecomte, P., additional, Litke, A. M., additional, Lüke, D., additional, Madaras, R. J., additional, Miller, D. H., additional, Parker, S. I., additional, Peruzzi, I., additional, Piccolo, M., additional, Pun, T. P., additional, Rapidis, P. A., additional, Ronan, M. T., additional, Ross, R. R., additional, Scharre, D. L., additional, Trippe, T. G., additional, and Yount, D. E., additional

Published
1978
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16. Inclusiveγandπ0Production ine+e−Annihilation

Author

Scharre, D. L., primary, Fong, A., additional, Pun, T. P., additional, Barbaro-Galtieri, A., additional, Dorfan, J. M., additional, Ely, R., additional, Feldman, G. J., additional, Feller, J. M., additional, Gobbi, B., additional, Hanson, G., additional, Jaros, J. A., additional, Kwan, B. P., additional, Lecomte, P., additional, Litke, A. M., additional, Lüke, D., additional, Madaras, R. J., additional, Martin, J. F., additional, Miller, D. H., additional, Parker, S. I., additional, Perl, M. L., additional, Peruzzi, I., additional, Piccolo, M., additional, Rapidis, P. A., additional, Ronan, M. T., additional, Ross, R. R., additional, Trippe, T. G., additional, Vuillemin, V., additional, and Yount, D. E., additional

Published
1978
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17. Inclusive Electron Production in Multiprong Events Produced bye+e−Annihilation

Author

Feller, J. M., primary, Litke, A. M., additional, Madaras, R. J., additional, Ronan, M. T., additional, Barbaro-Galtieri, A., additional, Dorfan, J. M., additional, Ely, R., additional, Feldman, G. J., additional, Fong, A., additional, Gobbi, B., additional, Hanson, G., additional, Jaros, J. A., additional, Kwan, B. P., additional, Lecomte, P., additional, Lüke, D., additional, Martin, J. F., additional, Miller, D. H., additional, Parker, S. I., additional, Perl, M. L., additional, Peruzzi, I., additional, Piccolo, M., additional, Pun, T. P., additional, Rapidis, P. A., additional, Ross, R. R., additional, Scharre, D. L., additional, Trippe, T. G., additional, Vuillemin, V., additional, and Yount, D. E., additional

Published
1978
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18. Evidence for DirectγProduction at Largexinψ(3100)Decay

Author

Ronan, M. T., primary, Trippe, T. G., additional, Barbaro-Galtieri, A., additional, Ely, R., additional, Feller, J. M., additional, Fong, A., additional, Gobbi, B., additional, Lecomte, P., additional, Litke, A. M., additional, Madaras, R. J., additional, Miller, D. H., additional, Parker, S. I., additional, Pun, T. P., additional, Ross, R. R., additional, Vuillemin, V., additional, and Yount, D. E., additional

Published
1980
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19. Electron-Muon and Electron-Hadron Production ine+e−Collisions

Author

Barbaro-Galtieri, A., primary, Kwan, B. P., additional, Litke, A. M., additional, Dorfan, J. M., additional, Ely, R., additional, Feldman, G. J., additional, Feller, J. M., additional, Fong, A., additional, Gobbi, B., additional, Hanson, G., additional, Jaros, J. A., additional, Lecomte, P., additional, Lüke, D., additional, Madaras, R. J., additional, Martin, J. F., additional, Mast, T. S., additional, Miller, D. H., additional, Parker, S. I., additional, Perl, M. L., additional, Peruzzi, I., additional, Piccolo, M., additional, Pun, T. P., additional, Rapidis, P. A., additional, Ronan, M. T., additional, Ross, R. R., additional, Sadoulet, B., additional, Trippe, T. G., additional, Vuillemin, V., additional, and Yount, D. E., additional

Published
1977
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20. Observation ofD0-Meson Decay intoK−π+π0

Author

Scharre, D. L., primary, Barbaro-Galtieri, A., additional, Dorfan, J. M., additional, Ely, R., additional, Feldman, G. J., additional, Feller, J. M., additional, Fong, A., additional, Gobbi, B., additional, Hanson, G., additional, Jaros, J. A., additional, Kwan, B. P., additional, Lecomte, P., additional, Litke, A. M., additional, Lüke, D., additional, Madaras, R. J., additional, Martin, J. F., additional, Miller, D. H., additional, Parker, S. I., additional, Perl, M. L., additional, Peruzzi, I., additional, Piccolo, M., additional, Pun, T. P., additional, Rapidis, P. A., additional, Ronan, M. T., additional, Ross, R. R., additional, Trippe, T. G., additional, Vuillemin, V., additional, and Yount, D. E., additional

Published
1978
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21. Measurement of Semileptonic Decays ofDMesons to Electrons at theψ(3772)

Author

Feller, J. M., primary, Litke, A. M., additional, Madaras, R. J., additional, Ronan, M. T., additional, Barbaro-Galtieri, A., additional, Dorfan, J. M., additional, Ely, R., additional, Feldman, G. J., additional, Fong, A., additional, Gobbi, B., additional, Hanson, G., additional, Jaros, J. A., additional, Kwan, B. P., additional, Lecomte, P., additional, Lüke, D., additional, Martin, J. F., additional, Mast, T. S., additional, Miller, D. H., additional, Parker, S. I., additional, Perl, M. L., additional, Peruzzi, I., additional, Piccolo, M., additional, Pun, T. P., additional, Rapidis, P. A., additional, Ross, R. R., additional, Sadoulet, B., additional, Trippe, T. G., additional, Vuillemin, V., additional, and Yount, D. E., additional

Published
1978
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23. Induction of apoptosis in peripheral blood lymphocytes following treatment in vitro with hydroxychloroquine.

Author

Meng XW, Feller JM, Ziegler JB, Pittman SM, and Ireland CM

Subjects
Antirheumatic Agents, Apoptosis drug effects, Cell Survival drug effects, Humans, Lupus Erythematosus, Systemic blood, T-Lymphocyte Subsets cytology, Hydroxychloroquine pharmacology, Lymphocytes cytology
Abstract

Objective: Defective regulation of apoptosis may be central to the development of autoimmune disorders. This study investigated the possibility that the antirheumatic effect of hydroxycholoroquine (HCQ) may be achieved by up-regulation of apoptosis., Methods: Peripheral blood lymphocytes collected from normal controls and patients with systemic lupus erythematosus (SLE) were cultured in the presence or absence of a range of concentrations of HCQ. Cells undergoing apoptosis were identified by several standard methods, including morphologic changes, DNA fragmentation, and flow cytometry. For some experiments, lymphocytes were simultaneously stained with antibodies to T cell surface markers and with propidium iodide for dual-stain flow cytometric studies., Results: HCQ was able to induce apoptosis in peripheral blood lymphocytes in a dose- and time-dependent manner. HCQ induced these changes in all T cell subpopulations studied. There was no significant difference between the controls and patients with SLE in terms of the percentage of apoptotic cells detected following treatment with HCQ., Conclusion: The present study demonstrated that HCQ induces apoptosis in peripheral blood lymphocytes, which leads to the speculation that HCQ may exert its antirheumatic effect through this mechanism.

Published
1997
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