8 results on '"Felipe S. Bernardes"'
Search Results
2. Correlation between Beta1 integrin expression and prognosis in clinically localized prostate cancer
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Jose Pontes-Junior, Sabrina Thalita Reis, Felipe S. Bernardes, Luiz C. N. Oliveira, Erika Aparecida Felix de Barros, Marcos Francisco Dall'oglio, Luciana M. S. Timosczuk, Leopoldo A. Ribeiro-Filho, Miguel Srougi, and Katia R. M. Leite more...
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Prostatic Neoplasms ,Cell Adhesion Molecules ,Prognosis ,Integrins ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Integrins are transmembrane glycoprotein receptors that regulate cell-matrix interactions, thus functioning as sensors from the environment. They also act as cell adhesion molecules that are responsible for the maintenance of the normal epithelial phenotype. Some studies have reported a correlation between carcinogenesis and changes in integrin expression, especially β1 integrin, however its role in prostate cancer (PC) is unclear. The aim of our study was to evaluate the expression of β1 integrin in localized PC and to correlate the pattern of expression with recurrence after surgical treatment. Methods For this case-control study, we retrospectively selected surgical specimens from 111 patients with localized PC who underwent radical prostatectomy. Recurrence was defined as a PSA level exceeding 0.2ng/mL after surgery, and the median follow-up was 123 months. Integrin expression was evaluated by immunohistochemistry in a tissue microarray containing two samples from each tumor. We employed a semiquantitative analysis and considered a case as positive when the expression was strong and diffusely present. Results: There was a loss of 11 cases during the tissue micro array assembling. β1 expression was positive in 79 of the 100 evaluated cases (79%). The univariate and multivariate analyses showed that the negative expression of β1 integrin was associated with biochemical recurrence (p = 0.047) and time to recurrence after radical prostatectomy (p = 0.023). When β1 was negative, the odds ratio for recurrence was 2.78 times higher than that observed in the positive cases [OR = 2.78, p = 0.047, IC 95% (1.01-7.66)]. Conclusions: The loss of β1 integrin immune expression was correlated with biochemical recurrence in patients treated with radical prostatectomy for localized PC. more...
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- 2013
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3. Viral infections and implications for male reproductive health
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Joël R. Drevet, Jorge Hallak, Sandro C. Esteves, Thiago A Teixeira, Esper G. Kallas, Yasmin C Oliveira, Amaro Nunes Duarte-Neto, Felipe S. Bernardes, Universidade de São Paulo = University of São Paulo (USP), Universidade Federal do Amapà (UNIFAP), Universidade Estadual de Campinas = University of Campinas (UNICAMP), Génétique, Reproduction et Développement (GReD), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), and Drevet, Joel more...
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Male ,viruses ,030232 urology & nephrology ,Review ,medicine.disease_cause ,Zika virus ,viral persistence ,0302 clinical medicine ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,[SDV.BDD.GAM]Life Sciences [q-bio]/Development Biology/Gametogenesis ,[SDV.BDD.GAM] Life Sciences [q-bio]/Development Biology/Gametogenesis ,[SDV.BDLR.RS] Life Sciences [q-bio]/Reproductive Biology/Sexual reproduction ,030219 obstetrics & reproductive medicine ,biology ,Zika Virus Infection ,semen ,General Medicine ,Hepatitis B ,Hepatitis C ,Reproductive Health ,Virus Diseases ,[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Infertility ,Sexual transmission ,Urology ,Mumps virus ,testis ,sperm ,Virus ,[SDV.BDLR.RS]Life Sciences [q-bio]/Reproductive Biology/Sexual reproduction ,reproduction ,03 medical and health sciences ,male genital tract ,sexual transmission ,medicine ,Humans ,Viral shedding ,Ebola virus ,Herpes Genitalis ,business.industry ,Papillomavirus Infections ,biology.organism_classification ,medicine.disease ,Virology ,Diseases of the genitourinary system. Urology ,RC870-923 ,business - Abstract
International audience; Viral infections have haunted humankind since times immemorial. Overpopulation, globalization, and extensive deforestation have created an ideal environment for a viral spread with unknown and multiple shedding routes. Many viruses can infect the male reproductive tract, with potential adverse consequences to male reproductive health, including infertility and cancer. Moreover, some genital tract viral infections can be sexually transmitted, potentially impacting the resulting offspring's health. We have summarized the evidence concerning the presence and adverse effects of the relevant viruses on the reproductive tract (mumps virus, human immunodeficiency virus, herpes virus, human papillomavirus, hepatitis B and C viruses, Ebola virus, Zika virus, influenza virus, and coronaviruses), their routes of infection, target organs and cells, prevalence and pattern of virus shedding in semen, as well as diagnosis/testing and treatment strategies. The pathophysiological understanding in the male genital tract is essential to assess its clinical impact on male reproductive health and guide future research. more...
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- 2021
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4. SARS‐CoV‐2 and its relationship with the genitourinary tract: Implications for male reproductive health in the context of COVID‐19 pandemic
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Jorge Hallak, Sérgio Aloísio Duarte, Esper G. Kallas, Thiago A Teixeira, Paulo Hilário Nascimento Saldiva, Juliana Risso Pariz, Sandro C. Esteves, Felipe S. Bernardes, and Felipe Carneiro
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Male ,kidney ,medicine.medical_specialty ,viruses ,Urology ,Endocrinology, Diabetes and Metabolism ,Urogenital System ,Context (language use) ,Disease ,testis ,medicine.disease_cause ,Risk Assessment ,sperm ,Sex Factors ,Endocrinology ,Risk Factors ,angiotensin-converting enzyme 2 ,Pandemic ,medicine ,Animals ,Humans ,Intensive care medicine ,Infertility, Male ,Reproductive health ,Coronavirus ,SARS-CoV-2 ,business.industry ,Genitourinary system ,Acute kidney injury ,COVID-19 ,Outbreak ,semen ,Prognosis ,medicine.disease ,Fertility ,Reproductive Health ,Reproductive Medicine ,Host-Pathogen Interactions ,business - Abstract
Background: The current outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, named coronavirus disease 19 (COVID-19), is not the first well-known spillover of an animal originated virus to infect humans. However, one of the few to make such a fast jump in a powerful evolutionary shortcut. The incredible pattern of aggressiveness worldwide since the beginning of the outbreak is that up to 20% of those infected need hospitalization and 5% evolve to critical conditions, not limited to respiratory-related issues, but rather to systemic involvement. Objective: This study aims to summarize the current knowledge about the effects of SARS-CoV-2 infection on the male genitourinary tract. Materials and methods: A narrative review was carried out to identify articles on the SARS-CoV-2 infection on the male genitourinary system. Results: Considerations were made about the molecular characteristics of SARS-CoV-2 and immune response to coronavirus. We discussed the influence of the virus on the urinary system, potential mechanisms of COVID-19- related acute kidney injury (AKI), and the role of cytokine release syndrome on the renal pathophysiology of the disease. In the male reproductive tract, it was discussed the testis' vulnerability to SARS-CoV-2 invasion and the possible adverse effects on its function and the seminal findings of COVID-19. Discussion and conclusion: During the COVID-19 pandemic, an international coordinated scientific effort must arise to understand the role of the urogenital system in the SARS-CoV-2 infection in the clinical setting. more...
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- 2020
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5. Radiological patterns of incidental epididymitis in mild‐to‐moderate COVID‐19 patients revealed by colour Doppler ultrasound
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Marcelo dos Santos Pereira, Esper G. Kallas, Felipe S. Bernardes, Thiago A Teixeira, Giovanna Milani, Amaro Nunes Duarte-Neto, Maria Cristina Chammas, Jorge Hallak, Paulo Hilário Nascimento Saldiva, and Felipe Carneiro more...
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Adult ,Male ,medicine.medical_specialty ,Urology ,030232 urology & nephrology ,testis ,Severity of Illness Index ,SARS‐CoV‐2 ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,COVID‐19 ,Severity of illness ,Hydrocele ,Humans ,Medicine ,Ultrasonography, Doppler, Color ,Young adult ,Pathological ,Epididymitis ,030219 obstetrics & reproductive medicine ,SARS-CoV-2 ,ultrasound ,business.industry ,Ultrasound ,COVID-19 ,Echogenicity ,Original Articles ,General Medicine ,medicine.disease ,Testicular Hydrocele ,Cross-Sectional Studies ,Asymptomatic Diseases ,Testicular Involvement ,Original Article ,Radiology ,business ,Brazil - Abstract
The testis is a potential target organ for SARS‐CoV‐2 infection. Our study intended to investigate any testicular involvement in mild‐to‐moderate COVID‐19 men. We conduct a cross‐sectional study in 18 to 55‐year‐old men hospitalised for confirmed COVID‐19. A senior radiologist executed the ultrasound with multi‐frequency linear probe in all participants, regardless of any scrotal complaints. Exclusion criteria involved any situation that could impair testicular function. Statistical analysis compared independent groups, classified by any pathological change. Categorical and numerical outcome hypotheses were tested by Fisher's Exact and Mann–Whitney tests, using the Excel for Mac, version 16.29 (p 1.2 cm (p = .002). Two distinct epididymitis’ patterns were reported: (a) disseminated micro‐abscesses (n = 6) and (b) inhomogeneous echogenicity with reactional hydrocele (n = 5). Both patterns revealed increased epididymal head, augmented Doppler flow and scrotal skin thickening. The use of colour Doppler ultrasound in mild‐to‐moderate COVID‐19 men, even in the absence of testicular complaints, might be useful to diagnose epididymitis that could elicit fertility complications. more...
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- 2021
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6. CRYOPRESERVED SEMINAL SAMPLES FROM PATIENTS WITH ACUTE COVID-19 HAVE THE WORST POST-THAW QUALITY WHEN COMPARED TO OTHER ANDROLOGICAL DISEASES
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Mayara Rodrigues, Ana Clara Monteiro Barduchi, Jorge Hallak, Juliana Risso Pariz, Larissa Namie Chiba, Heloisa Faquineti, Felipe S. Bernardes, Raul Segundo Sanchez, Thiago Teixeira, and Joël R. Drevet more...
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2019-20 coronavirus outbreak ,medicine.medical_specialty ,Reproductive Medicine ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Internal medicine ,Obstetrics and Gynecology ,Medicine ,business ,Cryopreservation ,Article - Published
- 2021
7. Abstract 428: Positive correlation of beta1 integrin expression and prognosis in clinically localized prostate cancer
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Felipe S. Bernardes, Carlo C. Passerotti, Ellen Hagopian, Sabrina T. Reis, Alberto A. Antunes, Marcos F. Dall'Oglio, Luiz Cn Oliveira, Luciana S. Timoszczuk, Jose Pontes, Nayara I. Viana, Miguel Srougi, Katia Rm Leite, and Leopoldo A. Ribeiro-Filho more...
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PCA3 ,Oncology ,Cancer Research ,medicine.medical_specialty ,Prostate cancer ,business.industry ,Internal medicine ,medicine ,Beta1 Integrin ,Positive correlation ,business ,medicine.disease - Abstract
Introduction and objective: Integrins are transmembrane glycoprotein receptors that regulate cell-matrix interactions, functioning as sensors of the environment. They also act as cell adhesion molecules, being responsible for the maintenance of the epithelial phenotype. Some studies have reported correlation between alterations of integrins expression and carcinogenesis, specially β1 integrin, but their role in prostate cancer is unclear. Our aim is to study the expression of β1 integrin and evaluate its association with recurrence of prostate cancer after surgical treatment Methods: For this case-control study, we selected 111 patients with localized tumor submitted to radical prostatectomy by the same surgeon. 60 of these patients have not presented recurrence after a median follow-up of 123 months. Recurrence was defined as a PSA level above 0.4ng/ml. Integrin expression was evaluated by immunohistochemistry in a Tissue Microarray containing two samples from each tumor. We employed a semiquantitative analysis and considered a case as positive when the expression was strong and diffusely present. We correlated expression with recurrence employing the χ2 test and p Results: Positive expression of β1 integrin was found in 79 out of 100 evaluated cases, ten cases were lost in the tissue microarray. Correlating expression with recurrence we found in the univariate analysis that negative expression of β1 integrin was statistically associated with recurrence (p=0,042) and time to recurrence after radical prostatectomy, when expression of β1 is negative, the odds of recurrence was two times higher than that observed in positive cases (p=0.026 – IC 95% [1.09; 3.83]. In multivariate analysis, including PSA and Gleason, β1 integrin remained independently associated with recurrence p=0.01. Conclusions: In the present study we have shown that a down regulation of β1integrin expression was significantly correlated with recurrence after radical prostatectomy for localized prostate cancer, making this integrin a potential candidate as a marker of prognosis. Larger series will be evaluated in order to confirm our initial findings Figure Kaplan Meier curve for recurrence-free survival according to β1expression in 111primaryPCa submitted to RP Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 428. doi:10.1158/1538-7445.AM2011-428 more...
- Published
- 2011
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8. Viral infections and implications for male reproductive health
- Author
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Thiago A Teixeira, Yasmin C Oliveira, Felipe S Bernardes, Esper G Kallas, Amaro N Duarte-Neto, Sandro C Esteves, Joël R Drevet, and Jorge Hallak
- Subjects
male genital tract ,reproduction ,semen ,sexual transmission ,sperm ,testis ,viral persistence ,viruses ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Viral infections have haunted humankind since times immemorial. Overpopulation, globalization, and extensive deforestation have created an ideal environment for a viral spread with unknown and multiple shedding routes. Many viruses can infect the male reproductive tract, with potential adverse consequences to male reproductive health, including infertility and cancer. Moreover, some genital tract viral infections can be sexually transmitted, potentially impacting the resulting offspring's health. We have summarized the evidence concerning the presence and adverse effects of the relevant viruses on the reproductive tract (mumps virus, human immunodeficiency virus, herpes virus, human papillomavirus, hepatitis B and C viruses, Ebola virus, Zika virus, influenza virus, and coronaviruses), their routes of infection, target organs and cells, prevalence and pattern of virus shedding in semen, as well as diagnosis/testing and treatment strategies. The pathophysiological understanding in the male genital tract is essential to assess its clinical impact on male reproductive health and guide future research. more...
- Published
- 2021
- Full Text
- View/download PDF
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