1. Potential High-Risk Drug-Drug Interactions Among Elderly Outpatients With Dementia: A Cross-Sectional Study
- Author
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Felipe Ferreira, Julia Silva Valério Diniz, Patrícia Medeiros-Souza, Marco Polo Dias Freitas, Einstein Francisco Camargos, Liana Tieko Evangelista Kusano, and Leopoldo Luiz dos Santos-Neto
- Subjects
aged ,drug interactions ,geriatrics ,dementia ,Nursing ,RT1-120 ,Geriatrics ,RC952-954.6 ,Public aspects of medicine ,RA1-1270 - Abstract
OBJECTIVE: To analyse the occurrence of potential high-risk drug-drug interactions in elderly individuals with dementia. METHODS: The sample was chosen from a geriatric outpatient clinic of the Multidisciplinary Center for the Elderly in the University Hospital of Brasília. This cross-sectional study included patients aged 60 or older with a diagnosis of dementia. The prescriptions were analyzed using the Lexi-Interact® database to identify possible potential drug-drug interactions. RESULTS: The study included 97 participants. Sixty-one patients (62.9%) had at least one clinically important potential drug-drug interactions (risks C and D). Of the 264 interactions identified, 23 (8.7%) were classified as risk D, 14 were pharmacodynamics and nine pharmacokinetic. CONCLUSION: The results of this study suggest an increased frequency in the occurrence of clinically significant potential drug-drug interactions in dementia patients. This reinforces the need for drug-drug interaction studies in specific populations.
- Published
- 2024