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Purpose: To present updated information on odontogenic keratocyst (OKC) classification, etiology, genetic and molecular alterations, epidemiology, clinical presentation, radiographic characteristics, histological and immune histochemical features, differential diagnosis, treatment, and controversies, as well as a literature review of case frequencies in different countries. Materials and Methods: Studies were selected using the key words 'odontogenic keratocyst,' 'odontogenic cysts,' 'odontogenic keratocyst and clinical study'. Full-text papers were reviewed on the basis of the inclusion and exclusion criteria. The literature search aimed to find articles that would show the frequency of OKC, dentigerous cyst, radicular cyst, and other cysts. Results: OKC presents local aggression and high recurrence; therefore, a better understanding of its clinical characteristics and the genetic and molecular factors involved in this peculiar and controversial lesion is required. It is always essential to discuss treatment alternatives. Although OKC is an entity with a high recurrence, aggressive treatment is not advisable in all cases because factors such as commitment to anatomical structures and possible complications should be considered. However, periodic radiographic controls are advised. Conclusion: To reduce the high number of present cases worldwide, it is important to improve knowledge on this pathology so that accurate diagnoses can be achieved and appropriate treatment can be provided. OKC presents local aggression and high recurrence; therefore, a better understanding is needed of the clinical characteristics and genetic and molecular factors involved in OKC. Furthermore, it is always essential to discuss treatment alternatives. [ABSTRACT FROM AUTHOR]

Genome integrity is essential for the health and continuity of species. Micronuclei are biomarkers of genotoxicity and protagonists of instability and genetic chaos. A micronucleus, or Howell-Jolly body, contains DNA independent of the nucleus, which originates from anaphase delay, whose membrane is unstable and prone to rupture without repair. The DNA contained in these structures can condense, replicate, divide, however, in an asynchronous manner to the nuclear genetic material, and can even undergo chromothripsis and reincorporate into the nucleus, which causes genetic chaos and thus cancer. On the other hand, if DNA from the micronucleus is released into the cytosol, it triggers a chronic inflammatory response, senescence and apoptosis. Thus, it is vital to timely detect individuals susceptible to genomic damage, which would allow prioritizing prophylactic care. Therefore, the objective was to make a descriptive review of the most used and innovative models in the micronucleus test and the cellular and molecular advances in the knowledge of these structures, as well as their health effects, to outline a perspective and propose them as a preventive alternative of easy execution in the detection of individuals vulnerable to genotoxic agents. We searched for articles in MEDLINE published in the years 2000-2023, which included the terms "micronuclei use and causes" and "micronuclei cause and consequences". The final inclusion was determined after a review of the abstracts and subsequent analysis of the full text; articles were not included once the contributions were repetitive. [ABSTRACT FROM AUTHOR]