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1. Massive Fetomaternal Hemorrhage Caused by an Intraplacental Choriocarcinoma: Case Report and Review of the Literature

Author: Felice Sorrentino, Teresa Silvestris, Francesca Greco, Lorenzo Vasciaveo, Guglielmo Stabile, Veronica Falcone, Andrea Etrusco, Antonio D’Amato, Antonio Simone Laganà, and Luigi Nappi
Subjects: intraplacental choriocarcinoma (IC), massive fetomaternal hemorrhage (FMH), placenta, gestational trophoblastic disease, Medicine (General), R5-920
Abstract: Intraplacental choriocarcinoma (IC) is a gestational trophoblastic neoplasia located within the placenta. Due to its silent presentation, more than half of the cases are diagnosed incidentally. An association with fetomaternal hemorrhage (FMH), stillbirth, and intrauterine growth restriction has been found. The aim of this review is to describe the clinical management of this rare condition stemming from a case report of an incidental diagnosis following an emergency cesarean section, and taking into account the available literature. Emergency interventions and examination of the placenta, even for the smallest IC lesion can ensure timely treatment and improve maternal and fetal outcomes.
Published: 2024
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2. Exploring the Father’s Role in Determining Neonatal Birth Weight: A Narrative Review

Author: Alessandro Libretti, Federica Savasta, Anthony Nicosia, Christian Corsini, Alberto De Pedrini, Livio Leo, Antonio Simone Laganà, Libera Troìa, Miriam Dellino, Raffaele Tinelli, Felice Sorrentino, and Valentino Remorgida
Subjects: anthropometry, birthweight, paternal influence on birthweight, Medicine (General), R5-920
Abstract: Birth weight, which exhibits variability across different populations, is influenced by a mix of genetic, environmental, and dietary factors originating from both the mother and father. Maternal characteristics, including age, socioeconomic status, prior pregnancies, weight, height, and weight increase throughout pregnancy, have a substantial influence on fetal growth and the health of the infant. On the other hand, the influence of paternal characteristics on the weight of newborns is still not fully comprehended in a consistent manner. Birth weight is an important factor that can help predict various maternal complications, such as the probability of having a C-section, experiencing postpartum hemorrhage or infections. It can also indicate future health challenges like asthma, cognitive impairment, and chronic diseases such as hypertension and diabetes. Nineteen publications were found through a thorough search of the Medline, PubMed, and Scopus databases, which provide insights into how paternal variables contribute to variations in birth weight. Significantly, the age of the father was found to be associated with higher chances of preterm birth and having a smaller size for gestational age in premature infants, while full-term children were more likely to have a larger size for gestational age. In addition, there is a constant correlation between the height of the father and the birth weight of the child. Taller dads are more likely to have babies with a higher birth weight and a lower likelihood of being small for gestational age (SGA). Although there were some discrepancies in the data about the weight and BMI of fathers, it was found that the height of fathers played a significant role in determining the size of the fetus and the weight of the newborn. While there may be differences in the conducted studies, these findings provide valuable insights into the complex connection between parental characteristics and fetal development. This data can be utilized to enhance clinical treatment strategies and enhance our comprehension of outcomes for neonates. Further homogeneous investigations are required to conclusively validate and build upon these findings.
Published: 2024
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3. Primary Malignant Melanoma of The Endocervix Uteri and Outpatient Hysteroscopy as a Diagnostic Tool: Case Report and Literature Overview

Author: Davide Dealberti, David Bosoni, Federica Spissu, Carla Pisani, Corinna Pizio, Luigi Nappi, Felice Sorrentino, Stefania Carlucci, and Guglielmo Stabile
Subjects: melanoma of the cervix, endocervix, hysteroscopy, malignant neoplasia, Medicine
Abstract: Mucosal malignant melanoma has a low incidence and only 2% are diagnosed in the gynecological tract. Diagnosis of primary cervical malignant melanoma is often challenging. The clinical presentation mimics other malignant cervical tumors, usually with abnormal bleeding or discharge. Cervical screening tests, such as cytology, often fail to detect malignant melanomas because of the rarity of the disorder, and histological evaluation of lesions is of paramount importance. The treatment is often based on regimens used for cutaneous malignant melanoma. We present the first case in the literature of primary malignant melanoma of the endocervix diagnosed by outpatient hysteroscopy and we have performed a narrative review of the literature on PubMed, Scopus and Web of Science from 1980 to December 2023, identifying 137 cases. The most common initial symptom was vaginal bleeding in 82.8% of cases, and 84.8% of patients were menopausal at the time of diagnosis. The first diagnostic modality was biopsy in 67.7%; 90% of patients underwent surgery and 64.5% of the deaths occurred within the first 12 months after diagnosis. Primary malignant melanoma of the cervix is extremely rare and difficult to diagnose at an early stage which is due to the aggressiveness of the disease and the non-specificity of the symptoms. To improve survival, early diagnosis is essential and hysteroscopy could be a useful tool in achieving it. It is crucial to increase the attention of gynecologists on primary malignant melanoma of the cervix to also perform a diagnostic hysteroscopy in case of doubtful symptoms.
Published: 2024
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4. Exploring the Relationship between Neuroticism and Perinatal Depressive Symptoms: Findings from a 2-Year, Multicenter Study in Italy

Author: Melania Severo, Annamaria Petito, Antonio Ventriglio, Salvatore Iuso, Giulio Ianzano, Alessia Marconcini, Elisa Giannaccari, Giuseppe Luigi Palma, Mario Altamura, Felice Sorrentino, Giuseppe Maruotti, Luigi Nappi, Antonella Caroli, and Antonello Bellomo
Subjects: neuroticism, personality, perinatal depression, pregnancy, EPDS, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract: Neuroticism is a personality trait associated with the risk of affective disorders and perinatal depression. We investigated the relationship between different levels of neuroticism, psychological characteristics, and depressive symptoms in a sample of pregnant women (N = 2631) who accessed the gynecology departments in the Puglia Region (Italy) from July 2020 to November 2022. Women were assessed for depressive symptoms and associated risk factors in their third trimester of pregnancy (T0) and after childbirth (T1), and followed-up at 6 months and 1 year after delivery if presenting signs of depression (T2–T3). The Edinburgh Postnatal Depression Scale (EPDS) was used to screen depressive symptoms, and neuroticism was assessed through the subscales of the NEO Five Factor Inventory. Standardized measures of resilience, coping strategies, partner attachment, and quality of life were also employed. Higher levels of neuroticism were significantly associated with: (a) higher scores on the EPDS; (b) higher anxiety in the experience of close relationships; (c) lower psychological wellbeing; (d) lower levels of resilience; (e) lower levels of active coping; and (f) higher levels of self-blame. Our findings may suggest that neuroticism is a specific associated factor of perinatal depression and should be routinely assessed in the clinical screening of pregnant women in order to promote an early referral to psychological or psychiatric support services.
Published: 2024
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5. Use of Diode Laser in Hysteroscopy for the Management of Intrauterine Pathology: A Systematic Review

Author: Andrea Etrusco, Giovanni Buzzaccarini, Antonio Simone Laganà, Vito Chiantera, Salvatore Giovanni Vitale, Stefano Angioni, Maurizio Nicola D’Alterio, Luigi Nappi, Felice Sorrentino, Amerigo Vitagliano, Tommaso Difonzo, Gaetano Riemma, Liliana Mereu, Alessandro Favilli, Panagiotis Peitsidis, and Antonio D’Amato
Subjects: diode laser, hysteroscopy, hysteroscopic surgery, endometrial polyps, fibroids, septate uterus, Medicine (General), R5-920
Abstract: Background: Hysteroscopy currently represents the gold standard for the diagnosis and treatment of intrauterine pathologies. Recent technological progress has enabled the integration of diagnostic and operative time, leading to the “see and treat” approach. Diode laser technology is emerging as one of the most innovative and intriguing techniques in this context. Methods: A comprehensive search of the literature was carried out on the main databases. Only original studies reporting the treatment of intrauterine pathologies using diode laser were deemed eligible for inclusion in this systematic review (PROSPERO ID: CRD42023485452). Results: Eight studies were included in the qualitative analysis for a total of 474 patients undergoing laser hysteroscopic surgery. Eighty-three patients had female genital tract abnormalities, 63 had submucosal leiomyomas, 327 had endometrial polyps, and one patient had a scar pregnancy. Except for leiomyomas, whose technique already included two surgical times at the beginning, only seven patients required a second surgical step. Cumulative rates of intraoperative and postoperative complications of 2.7% and 0.6%, respectively, were reported. Conclusions: Diode laser through “see and treat” hysteroscopy appears to be a safe and effective method. However, additional studies with larger sample sizes and improved designs are needed to consolidate the evidence currently available in the literature.
Published: 2024
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6. Obstetric outcomes in pregnant COVID-19 women: the imbalance of von Willebrand factor and ADAMTS13 axis

Author: Elvira Grandone, Antonella Vimercati, Felice Sorrentino, Donatella Colaizzo, Angelo Ostuni, Oronzo Ceci, Manuela Capozza, Giovanni Tiscia, Antonio De Laurenzo, Mario Mastroianno, Filomena Cappucci, Lucia Fischetti, Maurizio Margaglione, Ettore Cicinelli, and Luigi Nappi
Subjects: ADAMTS13, COVID-19, von Willebrand factor, AB0 blood group system, Pregnancy, Gynecology and obstetrics, RG1-991
Abstract: Abstract Background Thrombotic microangiopathy has been invoked as one of the most important mechanisms of damage in COVID-19 patients. Protease ADAMTS13 is a marker of microangiopathy responsible for controlling von Willebrand multimers size. Von Willebrand factor/ADAMTS13 ratio has been found impaired in COVID-19 patients outside pregnancy. Methods We prospectively investigated 90 pregnant women admitted to two tertiary academic hospitals in Italy with a laboratory-confirmed diagnosis of SARS-CoV-2 infection. Demographic, clinical information and routine laboratory data were collected at the hospital admission and until discharge. We investigated whether vonWillebrand /ADAMTS13 axis imbalance is a predictor of adverse outcomes. Logistic regression analysis, which controlled for potential confounders, was performed to evaluate the association between laboratory parameters and clinical outcomes. Results Most women (55.6%) were parae, with median gestational age at admission of 39 weeks. At hospital admission, 63.3% were asymptomatic for COVID-19 and 24.4% showed more than one sign or symptom of infection. Nulliparae with group O showed Willebrand / ADA MTS-13 ratios significantly lower than non-O, whereas in multiparae this difference was not observed. Logistic regression showed that ratio von Willebrand to ADAMTS13 was significantly and independently associated with preterm delivery (OR 1.9, 95%CI 1.1–3.5). Conclusion This study shows an imbalance of vonWillebrand /ADAMTS13 axis in pregnant women with COVID-19, leading to a significantly higher and independent risk of preterm delivery. Monitoring these biomarkers might support decision making process to manage and follow-up pregnancies in this setting.
Published: 2022
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7. Adenomyosis and Infertility: A Literature Review

Author: George Pados, Stephan Gordts, Felice Sorrentino, Michelle Nisolle, Luigi Nappi, and Angelos Daniilidis
Subjects: adenomyosis, diagnosis, classification, pathogenesis, infertility, treatment, Medicine (General), R5-920
Abstract: Background and Objectives: Adenomyosis (the presence of ectopic endometrial glands and stroma below the endometrial–myometrial junction) is a benign condition which is increasingly diagnosed in younger women suffering from infertility. The aim of this narrative review was to study the pathophysiology and prevalence of adenomyosis, the mechanisms causing infertility, treatment options, and reproductive outcomes in infertile women suffering from adenomyosis. Materials and Methods: A literature search for suitable articles published in the English language was performed using PubMed from January 1970 to July 2022. Results: The literature search retrieved 50 articles that met the purpose of this review and summarized the most recent findings regarding the accuracy of diagnostic methods, pathophysiology, and the prevalence of adenomyosis and optimal strategies for the treatment of infertile women with adenomyosis. Conclusions: Adenomyosis is a common gynecological disorder, affecting women of reproductive age. It negatively affects in vitro fertilization, pregnancy and the live birth rate, as well as increases the risk of miscarriage. With the advent of non-invasive diagnoses with MRI and TVUS, the role of adenomyosis in infertility has been better recognized. Overall, more randomized controlled trials (RCTs) are needed to provide strong data on the accuracy of diagnostic methods, the pathophysiology and the prevalence of adenomyosis, the fertility outcomes of patients and the optimal strategy for the treatment.
Published: 2023
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8. Aggressive Pelvic Angiomyxoma in a Patient with Twin Pregnancy: Diagnosis, Treatment, and Clinical Complications in Light of the Literature

Author: Carmen Imma Aquino, Raffaele Tinelli, Alessandro Libretti, Riccardo Bertinato, Renzo Luciano Boldorini, Michele Giana, Felice Sorrentino, Luigi Nappi, Valentino Remorgida, and Daniela Surico
Subjects: angiomyxoma, pregnancy, cancer, soft mass, Medicine (General), R5-920
Abstract: (1) Background: Aggressive angiomyxoma is a mesenchymal cancer that is rare during pregnancy. It is a neoplasm that relapses and infiltrates the nearest structures. Our aim is to evaluate the management and outcomes of an observed case, in light of the current literature. (2) Methods: We observed this condition at the “Maggiore della Carità” Hospital in Novara (Italy) in a patient with an initial twin pregnancy and a suspected pelvic mass. The words “angiomyxoma” and “pregnancy” were searched on the main online scientific search sources (PubMed, Google Scholar, Scopus, WES, and Embase, etc.). (3) Results: The patient underwent surgery with a complicated follow-up, but recent negative controls. We analyzed the literature about the topic and found only 24 similar clinical cases. (4) Conclusions: Considering the current literature, it is useful to assess an aggressive angiomyxoma in the differential diagnosis of soft masses in pregnant women. The treatment of choice is surgical excision, and vaginal delivery is feasible. The therapeutic decision depends on each case.
Published: 2023
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9. Ex vivo myolysis with dual wavelengths diode laser system: macroscopic and histopathological examination

Author: Maurizio Nicola D’Alterio, Francesco Scicchitano, Daniela Fanni, Gavino Faa, Antonio Simone Laganà, Marco Noventa, Felice Sorrentino, Luigi Nappi, and Stefano Angioni
Subjects: uterine fibroids, myolysis, diode laser, dwls, hysteroscopy, ex vivo, Gynecology and obstetrics, RG1-991
Abstract: Background: Uterine fibroids are the most common benign gynaecological tumours in women. When symptomatic, heavy menstrual bleeding is the principal manifestation of uterine fibroids. Nowadays, several conservative procedures have been utilized to discourage hysterectomy or myomectomy and great interest has been focused on laser energy technology associated with mini-invasive approaches. Diode lasers demonstrated many advantages in laparoscopic and hysteroscopic surgery. Methods: To evaluate the Dual Wavelength Diode Laser System (DWLS) ablation techniques for treating fibroids, we devised an experimental system for characterizing the myolysis fibre ablation performance with a particular fibre designed to create a thermal ablation in the centre of the myoma. All the myomas were used for the experiment after a total hysterectomy and their excision from the fresh uteri. The experiment setup was composed of two beaker containers filled with isotonic saline water, temperature monitoring myoma surface and water bath, a diode laser fibre and a diode laser energy deposition system. Results: Good macroscopic results have been found for fibroids of about 60 cm3 ablated with a setting of 10 W of 980 nm + 10 W of 1470 nm and for samples of about 15 cm3 ablated with a setting of 5 W of 980 nm + 5 W of 1470 nm, where the volume of the ablated fibroids were 46.6% and 41.6%, respectively. Conclusion: This is the first ex vivo study with a new DWLS, which made it possible to understand which one of its settings could be recommended for the safest and best macroscopic results in myolysis.
Published: 2021
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10. Left External Iliac Vein Injury During Laparoscopic Pelvic Lymphadenectomy for Early-Stage Ovarian Cancer: Our Experience and Review of Literature

Author: Raffaele Tinelli, Miriam Dellino, Luigi Nappi, Felice Sorrentino, Maurizio Nicola D'Alterio, Stefano Angioni, Giorgio Bogani, Salvatore Pisconti, Stefano Uccella, and Erica Silvestris
Subjects: injury, iliac vein, laparoscopy, lymphadenectomy, repair, ovarian cancer, Surgery, RD1-811
Abstract: Laparoscopic surgical staging is the standard treatment of early-stage ovarian tumors with similar survival outcomes if compared with laparotomic procedures. In this article, we report a case regarding an incidental external iliac vein injury during a pelvic lymphadenectomy for fertility sparing treatment of early-stage ovarian cancer with a video showing the laparoscopic repair without any consequence or side effect. A 36 year-old obese woman with Body Mass Index 30 kg/m2 referred at our hospital with an histological diagnosis of high grade ovarian serous carcinoma after a left laparoscopic salpingo-oophorectomy performed in another hospital. After an hysteroscopy with endometrial biopsy, a laparoscopic surgical staging with a pelvic and aortic lymphadenectomy with lymph-node dissection until the left renal vein, omentectomy, and appendectomy were performed. A thermal injury to the left external iliac vein occurred using the bipolar forceps during lymphadenectomy and was repaired after an immediate clamping of the site using endoclinch and the suction irrigator probe. The laceration on the iliac vein was successfully repaired using 10 mm laparoscopic titanium clips; after a follow-up of 42 months no recurrence was detected. In conclusion, laparoscopy is a safe and effective therapeutic option for fertility sparing treatment patients with early stage ovarian carcinoma with a significantly low morbidity and postoperative hospitalization, but it should be reserved for oncologic surgeons trained in advanced laparoscopic procedures and repair of vascular injuries potentially associated with high mortality rate.
Published: 2022
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11. Progression Free Survival, Overall Survival, and Relapse Rate in Endometrioid Ovarian Cancer and Synchronous Endometrial-Ovarian Endometrioid Cancer (SEO-EC): Results from a Large Retrospective Analysis

Author: Basilio Pecorino, Antonio Simone Laganà, Vito Chiantera, Martina Ferrara, Andrea Benedetto Di Stefano, Mariano Catello Di Donna, Felice Sorrentino, Luigi Nappi, Mislav Mikuš, and Paolo Scollo
Subjects: endometrioid ovarian cancer, synchronous endometrial-ovarian endometrioid cancer, lymphadenectomy, gynecological surgery, gynecological oncology, gynecological cancer, Medicine (General), R5-920
Abstract: Background and Objectives: We aimed to evaluate Progression Free Survival (PFS), Overall Survival (OS), and relapse rate in women affected by endometrioid ovarian cancer and synchronous endometrial-ovarian endometrioid cancer (SEO-EC). As secondary outcome, we assessed whether systematic pelvic and para-aortic lymphadenectomy could be considered a determinant of relapse rate in this population. Materials and Methods: We performed a retrospective analysis of women with diagnosis of endometrioid ovarian cancer or SEO-EC between January 2010 to September 2020, and calculated PFS, OS and relapse rate. Results: In almost all the patients (97.6%) who underwent systematic pelvic and para-aortic lymphadenectomy, there were no lymph node metastases confirmed by histology. We did not find a significant difference (p = 0.6570) for the rate of relapse in the group of women who underwent systematic pelvic and para-aortic lymphadenectomy (4/42; 9.5%) compared with the group of women who did not undergo the same procedure (1/21; 4.8%). During a median follow-up was 23 months, both PFS and OS were excellent. Conclusions: Women affected by early-stage low-grade endometrioid cancer and SEO-EC without apparent lymph node involvement at pre-operative imaging showed a very low rate of lymph node metastasis and similar relapse rate with or without lymphadenectomy.
Published: 2022
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12. Hysteroscopic Removal of Intrauterine Device in Pregnancy: A Scoping Review to Guide Personalized Care

Author: Guglielmo Stabile, Francesco Cracco, Luigi Nappi, Felice Sorrentino, Salvatore Giovanni Vitale, Stefano Angioni, Stefania Carlucci, and Giuseppe Ricci
Subjects: embryoscopy, intrauterine device, intrauterine system, hysteroscopy, pregnancy, Medicine (General), R5-920
Abstract: Background and objectives: Pregnancies that occur with an intrauterine device (IUD) in situ are at increased risk for developing severe conditions which may affect the fetus and the mother. The incidence of such adverse consequences significantly drops after device removal. A scoping review of the literature was performed to highlight the risks, benefits, and outcomes of hysteroscopic removal of intrauterine devices in early pregnancy. Materials and Methods: PubMed, Scopus, and Web of Science were searched. The review included all reports from 1990 to October 2022. The research strategy adopted included different combinations of the following terms: (“hysteroscopy”) AND (“pregnancy”) AND (“intrauterine device” or “IUD”) AND (“intrauterine system” or “IUS”). A scoping review of the hysteroscopic removal of IUDs during pregnancy was performed. All studies identified were listed by citation, title, authors, and abstract. Duplicates were identified by an independent manual screening performed by two researchers and then removed. For the eligibility process, two authors independently screened the titles and abstracts of all non-duplicated papers and excluded those not pertinent to the topic. Results: PRISMA guidelines were followed. Nine manuscripts were detected, accounting for 153 patients. Most IUD removals occurred during the first trimester of pregnancy. Most of the time, the procedure was safe and without consequences. Conclusions: This review highlights the safety and efficacy of operative hysteroscopy as a method of IUD removal in early pregnancy. We recommend using a 3 to 5 mm hysteroscope, avoiding cervical dilation, and maintaining low infusion pressure during the procedure to avoid potential damage to the gestational sac and IUD fragment displacement. Heating the distension media to 30 °C should be considered.
Published: 2022
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13. Caesarean Section on Maternal Request-Ethical and Juridic Issues: A Narrative Review

Author: Felice Sorrentino, Francesca Greco, Tea Palieri, Lorenzo Vasciaveo, Guglielmo Stabile, Stefania Carlucci, Antonio Simone Laganà, and Luigi Nappi
Subjects: caesarean section, medico-legal, CDMR, tokophobia, defensive medicine, Medicine (General), R5-920
Abstract: In recent decades, the rate of caesarean deliveries has increased worldwide. The reasons for this trend are still largely misunderstood and controversial among researchers. The decision often depends on the obstetrician, his beliefs and experience, the characteristics of the patients, the hospital environment and its internal protocols, the increasing use of induction of labor, the medico-legal implications, and, finally, the mother’s ability to request delivery by caesarean section without medical indication. This review aims to describe the reasons behind the increasing demand for caesarean sections by patients (CDMR) and strategies aimed at reducing caesarean section rates and educating women about the risks and benefits of CS.
Published: 2022
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14. Surgical Treatment Following Failed Medical Treatment of an Interstitial Pregnancy

Author: Stefano Restaino, Elena De Gennaro, Stefano Floris, Guglielmo Stabile, Giulia Zinicola, Felice Sorrentino, Giuseppe Vizzielli, and Lorenza Driul
Subjects: interstitial pregnancy, medical treatment, laparoscopy, salpingectomy, mifepristone, methotrexate, Medicine (General), R5-920
Abstract: Interstitial pregnancy (IP) is a type of ectopic pregnancy in which the embryo implants in the interstitial part of the Fallopian tube. It accounts for 2% of all ectopic pregnancies. Signs and symptoms appear later than the other forms of ectopic pregnancies because of its peculiar location. The gold standard for its diagnosis is transvaginal ultrasound. The treatment can be medical or surgical. Medical treatment is based on the systemic or local injection of methotrexate (MTX); a dose of mifepristone can be added with a reported 85–90% success rate. The surgical option is laparoscopic unilateral cornuostomy or unilateral salpingectomy. The therapeutic choice is based on symptoms, serum β-human chorionic gonadotropin (β-hCG) values, and sonographic features. Furthermore, the patient’s fertility perspectives should be considered. We report a case of IP in a Caucasian woman of 29 years old, with a previous salpingectomy for ectopic pregnancy medically treated by a double dose of intramuscular MTX 50 mg/m2 combined with a single dose of leucovorin 15 mg and a single dose of mifepristone 600 mg orally. Medical therapy failed as suggested by the sudden onset of intense pelvic pain after 10 days. Because of the clinical symptoms and the sonographic suspicious of pregnancy rupture due to the modest amount of fluid in the pouch of Douglas, clinicians decided on an urgent unilateral laparoscopic salpingectomy. The hemoperitoneum was drained. The patient was discharged two days later and β-hCG serum levels became negative after 45 days. The advantages of fertility sparing should be weighted according to the patient’s reproductive perspectives. Appropriate counseling is therefore key in managing the treatment of interstitial pregnancy.
Published: 2022
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15. Scar-Free Laparoscopy in BRCA-Mutated Women

Author: Stefano Restaino, Angelo Finelli, Giulia Pellecchia, Anna Biasioli, Jessica Mauro, Carlo Ronsini, Monica della Martina, Martina Arcieri, Luigi Della Corte, Felice Sorrentino, Lorenza Driul, and Giuseppe Vizzielli
Subjects: BRCA, oncology, laparoscopy, scar free, percutaneous, Medicine (General), R5-920
Abstract: Background and Objectives: BRCA 1 and 2 mutations have a cumulative risk of developing ovarian cancer at 70 years of 41% and 15%, respectively, while a cumulative risk of breast cancer by 80 years of age was 72% for BRCA1 mutation carriers and 69% for BRCA2 mutation carriers. The NCCN recommends risk-reducing salpingo-oophorectomy (RRSO), typically between 35 and 40 years, and upon completion of childbearing in BRCA1 mutation, while it is reasonable to delay RRSO for management of ovarian cancer risk until age 40–45 years in patients with BRCA2. In recent years there have been two main lines of evolution in laparoscopy. The former concerning the development of a single-site laparoscopic and the latter concerning the miniaturisation of laparoscopic instruments (mini/micro-laparoscopy). Materials and Methods: In this case report, we show our experience in prophylactic adnexectomy, on a mutated-BRCA patient, using the MiniLap® percutaneous surgical system. Results: This type of technique is safe and effective and does not require a particular learning curve compared to single-port laparoscopy. Conclusions: The considerable aesthetic advantage of the scars, we believe, albeit to a lesser extent, is useful to find in these patients burdened by an important stress load.
Published: 2022
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16. Case Report: Bowel Occlusion Following the Use of Barbed Sutures in Abdominal Surgery. A Single-Center Experience and Literature Review

Author: Guglielmo Stabile, Federico Romano, Davide De Santo, Felice Sorrentino, Luigi Nappi, Francesco Cracco, and Giuseppe Ricci
Subjects: barbed suture, bowel occlusion, laparoscopy, hernia surgical repair, myomectomy, Surgery, RD1-811
Abstract: Introduction: A high level of surgical ability is required to perform endoscopic knot tying. Barbed sutures help in avoiding this procedure, thus reducing intraoperative time and lowering blood loss and hospitalization time when compared to traditional sutures. Some cases of bowel occlusion following the use of barbed sutures have been described in literature. All of them are characterized by the entanglement of an intestinal loop in wire barbs with bowel occlusion symptoms.Case Presentation: We report two more cases which occurred in our Institute in 2020 and review those which have been reported in the literature by searching on Pubmed, Scopus, and Embase. We used the search terms: “Barbed,” ”Suture,” “Bowel,” and ”Obstruction.” We examined in the literature the surgical procedures, the type of complications, the time to onset of the complications, and the type of barbed suture.Discussion: Twenty-two cases in total were reported in the literature from 2011 to 2020, and bowel complications were largely subsequent to interventions such as hernia surgical repair and myomectomy. In order to take advantage of barbed sutures while minimizing the risk of adverse events, such as intestinal occlusion, some precautions may be considered, such as the shortening of thread tails and use of antiadhesive barriers. Moreover, performing a few stitches backwards when ending the suture might be a useful suggestion. Further studies in this field may be useful in order to assess whether it might be better avoiding barbed suture application on serosal tissues to prevent bowel damage.
Published: 2021
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17. Umbilical Cord Knots: Is the Number Related to Fetal Risk?

Author: Guglielmo Stabile, Stefania Carlucci, Lucia De Bonis, Felice Sorrentino, Luigi Nappi, and Giuseppe Ricci
Subjects: umbilical cord knot, true knot, double knot, fetal risk, Medicine (General), R5-920
Abstract: True knots of the umbilical cord (UC) are a rare occurrence and are reported in 0.4–1.2% of deliveries. The compression of true knot of the UC can cause obstruction of the fetal circulation, leading to intra-uterine growth retardation or fetal death. Predisposing factors for the genesis of the true UC knot are numerous and include all the conditions, which lead to a relatively large uterine volume. This situation may predispose to free and excessive fetal movements. Although not all true knots lead to perinatal complications, they have been associated with adverse pregnancy outcomes, including fetal distress, fetal hypoxia, intra-uterine growth restriction (IUGR), long-term neurological damage, caesarean delivery and stillbirth. We present a rare case of operative delivery with vacuum in a multiparous woman at term of pregnancy with a double true knot of the UC. As in most cases, the diagnosis was made after delivery, as there were no fetal symptoms during pregnancy. Some authors assume that 3D power sonography may be useful in the diagnosis of true UC knots. However, 3D power Doppler cannot be considered as a definitive method. There are no specific prenatal indications to induce the physician to look for ultrasound signs suggestive of umbilical true knot. Some studies argue that cases of fetal death and fetal risk are directly related to the number of knots. We also support this thesis, even if further observational and retrospective studies are needed to demonstrate it.
Published: 2022
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18. Eradication of Isolated Para-Aortic Nodal Recurrence in a Patient with an Advanced High Grade Serous Ovarian Carcinoma: Our Experience and Review of Literature

Author: Raffaele Tinelli, Miriam Dellino, Luigi Nappi, Felice Sorrentino, Maurizio Nicola D’Alterio, Stefano Angioni, Giorgio Bogani, Salvatore Pisconti, and Erica Silvestris
Subjects: aortic, lymphadenectomy, lymphnodes, ovarian cancer, recurrence, recurrent ovarian cancer, Medicine (General), R5-920
Abstract: We report a case report regarding the eradication of isolated lymph-nodal para-aortic recurrence in the aortic region down the left renal vein (LRV) in a patient treated two years earlier in another hospital for a FIGO stage IC2 high-grade serous ovarian carcinoma with a video showing the para-aortic space after eradication of the metastatic tissue. A 66 year-old woman was admitted 24 months after the initial surgical procedure for an increased Ca 125 level and CT scan that revealed a 3 cm para-aortic infrarenal lymph-nodal recurrence that was confirmed by PET/CT scan. A secondary cytoreductive surgery (SCS) with a para-aortic lymph-nodal dissection of the tissue down the LRV and radical omentectomy were performed: during the cytoreduction, the right hemicolon was mobilized. The anterior surface of the inferior vena cava (IVC), aorta and LRV were exposed. The metastatic lymph nodes were detected in the para-ortic space down the proximal part of the LRV and eradicated; an en bloc infrarenal lymph-node dissection from the aortocaval region was performed. The operative time during the surgical procedure was 212 min with a blood loss of 120 mL. No intra- and postoperative complications, including ureteral or vascular injury or renal dysfunction, occurred. At histological examination, three dissected lymph nodes were positive for metastasis, and the patient was discharged five days after laparotomy without side effects and underwent chemotherapy 3 weeks later; after a follow-up of 42 months, no recurrence was detected. In conclusion, secondary debulking surgery can be considered a safe and effective therapeutic option for the management of recurrences, although long-term follow-ups are necessary to evaluate the overall oncologic outcomes of this procedure.
Published: 2022
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19. Diagnostic accuracy of hysteroscopy vs dilation and curettage (D&C) for atypical endometrial hyperplasia in patients performing hysterectomy or serial follow-up

Author: Luigi Nappi, Stefano Angioni, Vincenzo De Feo, Pantaleo Greco, Guglielmo Stabile, Francesca Greco, Maurizio Nicola D'Alterio, and Felice Sorrentino
Subjects: endometrial hyperplasia (eh), office hysteroscopy (oh), dilation and curettage (d&c), transvaginal ultrasound (tvus), endometrial biopsy (eb), endometrial carcinoma, Gynecology and obstetrics, RG1-991
Abstract: Background: Endometrial hyperplasia (EH) is considered a heterogeneous pre-neoplastic clinical entity characterized by an abnormal glandular proliferation, with less than half of the tissue area occupied by the stroma. The aim of this retrospective study was to evaluate the correlation between the histological diagnosis of atypical endometrial hyperplasia (AEH) obtained through office hysteroscopy (OH) or uterine dilation and curettage (D&C) and the definitive histological evaluation after hysterectomy. Methods: Among 112 patients with atypical EH, 45 (40%) underwent hysteroscopy and 67 (60%) curettage. Results: The diagnostic accuracy of OH was very high: in particular, it showed a diagnostic coincidence in 87% of cases with the definitive histological diagnosis through hysteroscopy. The curettage, instead, had diagnostic coincidence only in 14% of cases. Conclusion: Office hysteroscopy is the ideal procedure for both diagnosis and follow-up of endometrial hyperplasia.
Published: 2022
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20. Fetal Noncompaction Cardiomyopathy and Histologic Diagnosis of Spongy Myocardium: Case Report and Review of the Literature

Author: Luigi Nappi, Lorenzo Vasciaveo, Felice Sorrentino, Gennaro Scutiero, Piergiorgio Iannone, and Pantaleo Greco
Subjects: noncompaction cardiomyopathy, spongy myocardium, left ventricular noncompaction cardiomyopathy, Gynecology and obstetrics, RG1-991
Abstract: Abstract Noncompaction cardiomyopathy (NCCM) and left ventricular noncompaction (LVNC), in their isolated form, are rare cardiomyopathies. They are characterized by a thickened myocardium due to the presence of deep trabeculae recesses, and to thick trabeculae. This condition is associated with a variable clinical phenotype including heart failure, thromboembolism, and sudden death. We report a case of LVNC at 26 weeks and 4 days of gestation revised on the basis of what is currently reported in the literature. A review of the literature was performed to better describe this rare condition. Left ventricular noncompaction is a rare fetal condition and it should be suspected in case of cardiomyopathy.
Published: 2018
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21. Data on correction of pelvic organ prolapse by laparoscopic lateral suspension with mesh: A clinical series

Author: Ruby Martinello, Gennaro Scutiero, Angelo Stuto, Ugo Indraccolo, Francesco Cracco, Chiara Borghi, Felice Sorrentino, Luigi Nappi, and Pantaleo Greco
Subjects: Computer applications to medicine. Medical informatics, R858-859.7, Science (General), Q1-390
Abstract: This DIB article provides additional data on laparoscopic lateral suspension with mesh for correcting pelvic organ prolapse. Data come from a multicentric sample of Italian women (https://doi.org/10.1016/j.ejogrb.2019.07.025). Data are collected retrospectively. Descriptive and raw data on surgery and descriptive and raw data on symptoms of pelvic organ prolapse pre-surgery and post-surgery are provided. Kaplan-Meier curves and scores of 7-items King's Health Questionnaire for quality of life assessment are also reported. Keywords: Pelvic organ prolapse, Laparoscopic lateral suspension, Surgical treatment, Mesh
Published: 2019
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22. Cesarean Scar Pregnancy Treated by Artery Embolization Combined with Diode Laser: A Novel Approach for a Rare Disease

Author: Felice Sorrentino, Vincenzo De Feo, Guglielmo Stabile, Raffaele Tinelli, Maurizio Nicola D’Alterio, Giuseppe Ricci, Stefano Angioni, and Luigi Nappi
Subjects: scar pregnancy, hysteroscopy, uterine artery embolization (UAE), laser, Medicine (General), R5-920
Abstract: Cesarean scar pregnancy (CSP) is a rare form of ectopic pregnancy which represents a consequence of a previous cesarean section. It is associated with major maternal morbidity and mortality and has potential implications on future fertility. Because of possible serious complications, CSP should be swiftly diagnosed and treated. There is no management protocol for this rare, life-threatening condition, and each patient should be evaluated individually. Several types of conservative treatment have been used to treat cesarean scar pregnancy: dilation and curettage (D&C), excision of trophoblastic tissues, local or systemic administration of methotrexate, bilateral hypogastric artery ligation, and selective uterine artery embolization with curettage and/or methotrexate administration. In our study we present a cesarean scar pregnancy of a 40-year-old woman who was treated with angiographic uterine artery embolization (UAE) followed by hysteroscopic diode laser resection. Our combined UAE–hysteroscopic laser surgery appears to offer an effective, safe, and minimally invasive surgical treatment.
Published: 2021
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23. Comments on: Isolated Nonocompaction Suggests Subclinical Myopathy

Author: Josef Finsterer, Luigi Nappi, Lorenzo Vasciaveo, Felice Sorrentino, Gennaro Scutiero, Piergiorgio Iannone, and Pantaleo Greco
Subjects: Gynecology and obstetrics, RG1-991
Published: 2019
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24. International Urogynecological Consultation (IUC): pathophysiology of pelvic organ prolapse (POP)

Author: Jan A. Deprest, Rufus Cartwright, Hans Peter Dietz, Luiz Gustavo Oliveira Brito, Marianne Koch, Kristina Allen-Brady, Jittima Manonai, Adi Y. Weintraub, John W. F. Chua, Romana Cuffolo, Felice Sorrentino, Laura Cattani, Judith Decoene, Anne-Sophie Page, Natalie Weeg, Glaucia M. Varella Pereira, Marina Gabriela M. C. Mori da Cunha de Carvalho, Katerina Mackova, Lucie Hajkova Hympanova, Pamela Moalli, Oksana Shynlova, Marianna Alperin, and Maria Augusta T. Bortolini
Subjects: Pregnancy, Urology, Vagina, Parturition, Humans, Obstetrics and Gynecology, Female, Delivery, Obstetric, Referral and Consultation, Pelvic Organ Prolapse
Abstract: This manuscript is the International Urogynecology Consultation (IUC) on pelvic organ prolapse (POP) chapter one, committee three, on the Pathophysiology of Pelvic Organ Prolapse assessing genetics, pregnancy, labor and delivery, age and menopause and animal models.An international group of urogynecologists and basic scientists performed comprehensive literature searches using pre-specified terms in selected biomedical databases to summarize the current knowledge on the pathophysiology of the development of POP, exploring specifically factors including (1) genetics, (2) pregnancy, labor and delivery, (3) age and menopause and (4) non-genetic animal models. This manuscript represents the summary of three systematic reviews with meta-analyses and one narrative review, to which a basic scientific comment on the current understanding of pathophysiologic mechanisms was added.The original searches revealed over 15,000 manuscripts and abstracts which were screened, resulting in 202 manuscripts that were ultimately used. In the area of genetics the DNA polymorphisms rs2228480 at the ESR1 gene, rs12589592 at the FBLN5 gene, rs1036819 at the PGR gene and rs1800215 at the COL1A1 gene are significantly associated to POP. In the area of pregnancy, labor and delivery, the analysis confirmed a strong etiologic link between vaginal birth and symptoms of POP, with the first vaginal delivery (OR: 2.65; 95% CI: 1.81-3.88) and forceps delivery (OR: 2.51; 95% CI: 1.24-3.83) being the main determinants. Regarding age and menopause, only age was identified as a risk factor (OR : 1.102; 95% CI: 1.02-1.19) but current data do not identify postmenopausal status as being statistically associated with POP. In several animal models, there are measurable effects of pregnancy, delivery and iatrogenic menopause on the structure/function of vaginal support components, though not on the development of POP.Genetics, vaginal birth and age all have a strong etiologic link to the development of POP, to which other factors may add or protect against the risk.
Published: 2022
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25. Multi-port robotic assisted (Da Vinci) laparoscopic myomectomy: a systematic review and meta-analysis of comparative clinical and fertility outcomes

Author: Elias Tsakos, Emmanouil Xydias, Apostolos C. Ziogas, Felice Sorrentino, Luigi Nappia, Nikolaos Vlachos, and Aggelos Daniilidis
Published: 2023
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26. New Topical Therapy for Provoked Vestibulodynia: Improvement of Psychological and Sexual Well-Being

Author: Francesco De Seta, Patrizia Ianniello, Stefania Carlucci, Luigi Nappi, Felice Sorrentino, and Guglielmo Stabile
Subjects: Health, Toxicology and Mutagenesis, topical therapy, Public Health, Environmental and Occupational Health, provoked vestibulodynia, new therapy, vulvodynia, sexual well-being, vulvar vestibulitis syndrome
Abstract: Vulvodynia is a vulvar discomfort that occurs in the absence of any specific, clinically identifiable disorder. Few therapies have shown to be effective for the treatment of vulvodynia. In our recently published study, we tested a drug-free gel in women affected by vulvar vestibulitis. It is a cosmetic gel which acts locally without any metabolic, pharmacological or immunological effect. In order to further promote the validity of this new product, in this manuscript we analyzed the results obtained from the administration of four questionnaires in the same two groups of women affected by PVD and treated with a placebo and the new product. The questionnaires used: Female Sexual Function Index Scoring (FSFI), Female Sexual Distress Scale (FSDS), Hospital Anxiety and Depression Scale (HADS), and health-related quality of life measured by SF-36 (SF-36). The results obtained by this current analysis showed that the new gel has also proven benefits on women’s quality of life and sexual function, including improvements in arousal, desire, orgasm and satisfaction.
Published: 2023
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27. Research development of a new GnRH antagonist (Elagolix) for the treatment of endometriosis: a review of the literature

Author: Alessandro, Pontis, Luigi, Nappi, Felice, Sorrentino, Maria, Paoletti Anna, Benedetto, Melis Gian, and Stefano, Angioni
Published: 2017
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28. Pathophysiology of Female Reproduction and Clinical Management

Author: Luigi Nappi, Felice Sorrentino, Francesca Greco, Laura Vona, Francesco Maria Zullo, and Stefano Bettocchi
Abstract: The female genital system is made up of dynamic organs that change during the woman’s life cycle. Ovarian cycle consists of the growth and development of the ovarian follicle, its bursting, and transformation into the corpus luteum with relative production of estrogens and progesterone.The normal menstrual cycle is the result of the integration of the primary neuroendocrine complex (the hypothalamus–pituitary–ovarian axis) into a control system regulated by a series of peripheral mechanisms of feedback and nerve signals that result in the release of a single mature oocyte from a pool of hundreds of thousands of primordial oocytes. Alterations of these mechanisms can lead to pathological conditions and affect fertility of patients.
Published: 2022
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29. Erratum: Searches for continuous gravitational waves from 15 supernova remnants and fomalhaut b with advanced LIGO (2019, ApJ, 875, 122)*

Author: A. Parida, S. S. Eikenberry, F. Frasconi, Chris A. Collins, R. Flaminio, Marcus E. Lower, Rosa Poggiani, V. Frey, E. K. Wessel, Nikhil Sarin, Odylio D. Aguiar, I. W. Martin, S. Farinon, P. Raffai, Andrew Matas, C. F. Da Silva Costa, M. A. Okada, G. Rutins, Graham Woan, Sebastiano Bernuzzi, D. Passuello, A. Cirone, H. S. Chen, Hyun Lee, J. D. Lough, K. Mason, S. A. Bilgili, E. C. Ferreira, Robert L. Byer, J. Calderón Bustillo, Sanjeev Dhurandhar, O. Halim, N. A. Robertson, Stuart Reid, F. J. Hayes, Patrick Godwin, N. Sennett, P. Kumar, Jacob Scheuer, B. R. Hall, J. Hanks, R. M. Martin, David A. Nichols, Edward K. Porter, J. G. Bartlett, Márton Tápai, K. W. Tsang, C. Horst, W. A. Campbell, Andreas Freise, C. V. Kalaghatgi, M. Rakhmanov, G. Pagano, Paul D. Lasky, J. W. Westhouse, M. C. Araya, Srishti Tiwari, C. Lazzaro, Patricia Schmidt, V. Brisson, Bernard F. Schutz, Li Ju, Matthew Pitkin, D. Cohen, Kiran Prasai, P. J. Veitch, S. A. Usman, C. Messenger, Liam Cunningham, E. A. M. Muniz, Daniel A. Shaddock, P. Gruning, Brittany Kamai, Riccardo Ciolfi, Alberto Vecchio, Geoffrey Mo, J. M. Fishner, Roman Schnabel, J. Hanson, M. Wade, M. Montani, P. Sharma, Héctor Estellés, N. Letendre, F. Ricci, A. Lenon, J. E. Brau, A. A. van Veggel, Richard Gray, Efim A. Khazanov, Peter T. H. Pang, C. Affeldt, G. Ballardin, Moritz Mehmet, A. A. Ciobanu, M. Granata, Minchuan Zhou, F. Marion, P. Brockill, Nancy Aggarwal, Hang Yu, P. G. Murray, Fabien Kéfélian, J. H. Hough, P. W. F. Forsyth, S. R. Thondapu, J. R. Palamos, Michele Zanolin, S. Mukherjee, T. J. Massinger, T. Vo, V. Kalogera, N. Leroy, G. D. Hammond, Javed Rana, H. Fong, G. Greco, M. Haney, T. A. Callister, Alec Mishkin, R. Cavalieri, S. R. P. Mohapatra, G. Giordano, K. Toland, A. K. Srivastava, A. E. Pace, H. Ohta, Vuk Mandic, B. Bécsy, M. Kasprzack, I. Dave, B. D. Lackey, R. L. Ward, Scott Coughlin, A.J. Weinstein, K. H. Lai, M. Phelps, H. S. Cho, L. Kuo, H. Yamamoto, E. Capocasa, M. Chan, S. Walsh, D. J. McManus, A. Schönbeck, B. Rajbhandari, Andrew Mehta, S. D. Linker, R. Robie, M. Fletcher, B. Hughey, R. D. Kennedy, José A. Font, Gregorio Carullo, S. Kumar, J. Prasad, H. K. Gulati, V. Raymond, Steven Bloemen, H. J. Bulten, Shiuh Chao, P. J. Sutton, N. Singh, C. Buy, Samuele Cortese, J. McIver, Vivishek Sudhir, P. A. Altin, A. Basti, N. A. Lockerbie, E. Schreiber, Charalampos Markakis, P. Grassia, Kipp Cannon, M. Steinke, P.H. Nguyen, Ryan N. Lang, Z. Doctor, Alyssa Garcia, J. H. Romie, Carlos O. Lousto, S. Sitmukhambetov, Alejandro Torres-Forné, A. Samajdar, D. M. Wysocki, T. Mistry, Mark A. Scheel, Charlie Hoy, F. Clara, M. A. Aloy, T. M. Evans, C. North, Thomas Dent, P. Corban, P. Ajith, B. Mours, Mandar Patil, Abhirup Ghosh, J. Neilson, Bala R. Iyer, Y. K. Lecoeuche, M. Muratore, Karsten Danzmann, Fabrizio Barone, N. Mukund, P. B. Covas, M. C. Edwards, T. Hinderer, Marta Colleoni, J. A. Giaime, Michael Pürrer, R. Pedurand, Benno Willke, A. Grado, D. C. Vander-Hyde, S. S. Y. Chua, J. Eichholz, J.-P. Coulon, Hua Wang, E. A. Chase, J. Betzwieser, G. Kang, L. R. Cominsky, O. A. Hannuksela, Z. Frei, A. Pal-Singh, S. Caride, Kevin Barkett, N. Bode, S. E. Gossan, Tristan Briant, R. Gustafson, Antoine Heidmann, Rana X. Adhikari, S. McCormick, C. Casentini, Slawomir Gras, D. Töyrä, H. Overmier, S. W. S. Ng, G. Wang, M. C. Heintze, J. S. Areeda, I. Belahcene, B. B. Lane, N. Mazumder, Maher Yazback, F. Donovan, J. Bosveld, N. A. Holland, N. V. Keerthana, M.L. Walker, C. Cahillane, L. Sun, M. C. Milovich-Goff, Dániel Barta, J. D. E. Creighton, V. Gayathri, P. Puppo, J.-D. Fournier, S. J. Kapadia, A. L. Stuver, A. S. Sengupta, H. W. Lee, I. Di Palma, S. T. Countryman, Francesco Pannarale, E. A. Huerta, J. L. Wright, Alessandra Corsi, B. W. Schulte, A. Rocchi, J. P. Zendri, R. Kashyap, Chandra Kant Mishra, R. Bhandare, Sylvain Marsat, Lee McCuller, T. Bulik, T. D. Abbott, O. Puncken, J. M. Gonzalez Castro, Philip F. Hopkins, C. Cocchieri, B. Goncharov, R. Birney, M. Kinley-Hanlon, I. Fiori, Shawn Rosofsky, Jun Liu, S. Raja, S. E. Strigin, D. Sellers, J. Meidam, Jeff R. Powell, Riccardo Sturani, D. Hoak, Stefan L. Danilishin, Patrick Brady, L. Matone, Haocun Yu, M. Landry, R. M. S. Schofield, Surabhi Sachdev, Christopher J. Moore, V. Avendano, R. Mittleman, Nelson Christensen, Geoffrey Lovelace, Soichiro Morisaki, John Worden, P. Couvares, Carl-Johan Haster, O. J. Piccinni, L. Rolland, C. L. Romel, Miriam Cabero, Alessandra Buonanno, L. Wallace, S. Biscoveanu, M. B. Shaner, Benjamin J. Owen, Alexander Urban, Antoni Ramos-Buades, V. V. Frolov, A. Singhal, F. Carbognani, Jordan Camp, R. L. Savage, A. S. Bell, M. Laxen, Anchal Gupta, A. Królak, B. D. Cheeseboro, G. Cerretani, P. J. Easter, J. F. J. van den Brand, M. J. Szczepańczyk, L. Di Fiore, E. Bonilla, S. Sunil, M. Tacca, Jessica Steinlechner, A. Neunzert, P.-F. Cohadon, M. Heurs, Irina Kowalska, E. Katsavounidis, Xiuling Li, C. I. Torrie, Jan Harms, Kazuhiro Agatsuma, Kin Sing Stephen Lee, Frank Ohme, M. Tonelli, R. De Rosa, Kwan-Lok Li, I. Nardecchia, Reed Essick, Martin Hendry, Cecilio García-Quirós, S. Kandhasamy, M. Fishbach, B. Sorazu, Christopher Wipf, Archisman Ghosh, A. P. Lundgren, Gabrielle Allen, E. J. Daw, M. Punturo, F. Garufi, Antonio Marquina, Surendra Nadh Somala, I. Dorrington, Robert J. McCarthy, T. A. Ferreira, R. Frey, Joseph Smith, S. Brunett, J. Zweizig, A. W. Heptonstall, E. L. Merilh, D. Barker, K. D. Giardina, Denis Martynov, Marco Bazzan, C. Ingram, L. Pinard, L. Naticchioni, Salvatore Vitale, R. Kirchhoff, B. L. Pearlstone, N. Man, Antonios Kontos, D. Moffa, J. J. McCann, J.-M. Isac, D. Hofman, Linqing Wen, A. Bisht, A. Kutynia, M. A. Page, Tyson Littenberg, Z. Tornasi, Junwei Cao, Sebastian Steinlechner, T. J. Slaven-Blair, S. ShyamSundar, C. Stachie, Hongyu Shen, O. de Varona, J. B. Kanner, Federico Ferrini, Lijing Shao, G. Vajente, S. M. Gaebel, Christopher P. L. Berry, S. H. Huttner, G. M. Harry, Andrea Chincarini, K. Venkateswara, Yuri Levin, C. Austin, C.D. Booth, M. Barsuglia, S. Appert, A. Giazotto, P. Shawhan, I. Ferrante, T. Z. Summerscales, A. Viceré, T. Huynh-Dinh, Fabio Hernandez, H. Cao, Ashok Kumar, D. J. Vine, W. Katzman, Alena Ananyeva, D. C. Coyne, Stanislav Babak, Rico K. L. Lo, Kendall Ackley, R. K. Nayak, F. Y. Khalili, Ken K. Y. Ng, A. Hreibi, M. Thomas, D. Fiorucci, Manuela Rizzo, H. Radkins, A. Bozzi, A. K. Prajapati, A. R. Wade, M. Agathos, M. Brinkmann, R. Quitzow-James, N. N. Janthalur, B. Sassolas, K. Izumi, L. Xiao, J. S. Lange, H. Y. Chia, M. C. Díaz, W. S. Kim, M. H. Wimmer, K. Haughian, S. Hochheim, M. Yvert, M. Nery, Marc Favata, L. E. Wade, Roger Jones, V. J. Roma, A. P. Spencer, G. Kuehn, C. M. Mow-Lowry, Sergey P. Vyatchanin, Andrew Melatos, M. Lorenzini, A. Masserot, M. Khursheed, Ettore Majorana, Robert Stone, Alessandro Nagar, D. D. Brown, Anthony A. Amato, N. van Bakel, Sebastien Biscans, P. Fulda, P. Charlton, F. Magaña-Sandoval, L. Aiello, M. Gosselin, A. R. Williamson, D. Huet, R. Green, M. Was, M. C. Tringali, A. K. Zadrożny, E. E. Cowan, V. Boschi, L. Zhang, J. H. Klika, M. Bawaj, J. Junker, M. van Beuzekom, K. W. Chung, David Coward, T. Hardwick, D. Steinmeyer, F. Travasso, M. Constancio, A. Allocca, Sascha Husa, G. Venugopalan, D.B. DeBra, Mikhail L. Gorodetsky, C. Whittle, Z. Khan, P. Ehrens, Paul M. Ricker, Y. Setyawati, H. Khan, S. E. Barclay, B. F. Whiting, F. Brighenti, C. Talbot, J. H. Briggs, J. Casanueva Diaz, D. H. Reitze, A. F. Brooks, P. J. Quinonez, V. Kringel, J. L. Willis, Ofek Birnholtz, M. F. Carney, P. Schale, R. Bonnand, Mariana Fazio, H. Vocca, C. Van Den Broeck, E. Sowell, Albrecht Rüdiger, Xing-Jiang Zhu, Jochen Kissel, Felice Sorrentino, V. Srivastava, D. Talukder, Michał Bejger, M. Standke, M. Croquette, David A. Williams, A. Effler, I. W. Harry, D. Mukherjee, Y. R. Chen, J. Jiang, Alessandro Bertolini, M. Fays, D. Moraru, J. C. Driggers, Matthew Evans, M. Bitossi, G. Bergmann, K. Wette, M. M. Hanke, Leo Singer, E. Cesarini, M. Hulko, T. D. Creighton, Eugeniy E. Mikhailov, Jörg Hennig, Eric Howell, A. Strunk, G. Vedovato, L. E. H. Datrier, D. B. Kozak, D. Stocks, C. Vorvick, P. Thomas, M. Arène, S. B. Anderson, Tim Dietrich, A. Perreca, G. Gemme, A. Di Lieto, R. A. Eisenstein, S. J. Chamberlin, Jishnu Suresh, G. D. Meadors, Z. A. Warden, R. Gouaty, T. Zelenova, Riccardo Bassiri, John J. Oh, M. Vasúth, Jonathan Cripe, N. Kijbunchoo, E. Cuoco, Sheelu Abraham, K. Kawabe, S. M. Aston, Michael W. Coughlin, G. D. O'Dea, Bruno Giacomazzo, Giuseppe Intini, M. Drago, Guenakh Mitselmakher, B. A. Boom, A. M. Sergeev, T. Etzel, J.-G. Ducoin, M. Eisenmann, A. Dmitriev, S. Leavey, Hai-Ping Cheng, A. Iess, L. K. Nuttall, D. Wilken, S. Katsanevas, R. Goetz, C. Adams, R. M. Blair, D. Sigg, S. W. Ballmer, D. M. Shoemaker, Binlei Ding, V. Bossilkov, Lindsay DeMarchi, I. Khan, K. Siellez, D. Sentenac, R. Macas, G. Billingsley, S. Macfoy, Sergio Gaudio, D. B. Tanner, A. Trovato, Olivier Minazzoli, Magnus Manske, M. Razzano, C. C. Yancey, F. Vetrano, Zachariah B. Etienne, Jennifer Watchi, E. Maros, R. C. Walet, V. P. Mitrofanov, R. Colgan, C. S. Unnikrishnan, G. Moreno, V. Kondrashov, P. Leaci, S. Meshkov, Seog Oh, S. P. Stevenson, Achamveedu Gopakumar, R. Inta, C. J. Richardson, S. Klimenko, M. J. Yap, C. Palomba, W. G. Anderson, G. Cella, F.L. Linde, P. Booker, L. Milano, S. C. Tait, N. V. Krishnendu, A. Pasqualetti, W. Del Pozzo, W. M. Farr, A. C. Green, Fausto Acernese, M. Korobko, B. C. Pant, C. Messick, J. Derby, J. Healy, K. A. Thorne, A. Cumming, M. Denys, M. Tse, S. Ascenzi, S. E. Dwyer, R. M. Magee, David Keitel, V. Germain, S. J. Cooper, Giacomo Ciani, K. Rao, Yongjung Kim, Peter Weßels, I. A. Bilenko, L. Haegel, David J. Ottaway, B. P. Abbott, H. Vahlbruch, J. C. Mills, E. K. Gustafson, K. Riles, J. Y. Vinet, H. Middleton, S. Doravari, H. Heitmann, Piotr Jaranowski, M. S. Shahriar, P. Ruggi, M. Weinert, H. A. G. Gabbard, D. M. Macleod, Karan Jani, B. L. Swinkels, Arunava Mukherjee, S. Privitera, L. Glover, Imre Bartos, Isabel Cordero-Carrión, H. Qi, E. Genin, J. Zhang, F. Baldaccini, B. U. Gadre, A. Lartaux-Vollard, B. Irwin, R. Shink, L. Rei, Huang-Wei Pan, Gijs Nelemans, S. Vass, Kenneth A. Strain, Jimin George, R. Coyne, C. Gray, G. H. Ogin, T. J. Shaffer, M. Sieniawska, Fabrice Matichard, A. Paoli, K. A. Santiago, F. Fidecaro, G. M. Guidi, G. Cagnoli, Arnold Miller, H. N. Isa, Suvadeep Bose, V. Tiwari, V. Quetschke, Yann Bouffanais, Martin M. Fejer, L. F. Ortega, D. Lumaca, M. Pedraza, R. Bork, S. Ghonge, Y. Minenkov, P. Bacon, K. AultONeal, K. Chakravarti, E. D. Hall, L. Sammut, Lionel London, D. George, R. K. Lanza, Y. Boetzel, Alexander C. Jenkins, P. Dupej, Eric B. Flynn, Z. Márka, M. Mantovani, T. Prestegard, D. W. Yeeles, Xie Chen, A. Markowitz, Fabio Marchesoni, P. Hello, Samuel Deléglise, M. Merzougui, A. Fernandez-Galiana, S. M. Scott, M. Obergaulinger, Turlough P. Downes, F. Cavalier, A. Ain, R. J. Trudeau, K. Holt, Chunglee Kim, L. van der Schaaf, S. A. Pai, C. De Rossi, W. Parker, A. Gennai, Rahul Kumar, Harald P. Pfeiffer, Milan Gupta, G. Dálya, B. Gateley, G. Cho, J. C. Bayley, Aaron Buikema, V. Sandberg, E. J. King, M. J. Cowart, S. Koley, M. Boer, G. Mendell, S. J. Jadhav, B. Idzkowski, V. Loriette, V. Skliris, J. K. Blackburn, E. Chassande-Mottin, Shubhanshu Tiwari, G. Koekoek, L. Trozzo, C. Pankow, P. M. Meyers, Koh Ueno, Christian Pedersen, Albert Lazzarini, Kyungmin Kim, N. Koper, H. Wittel, M. Deenadayalan, B. O'Reilly, A. W. Jones, Sheila Rowan, S. G. Schwalbe, D. Pascucci, R. De Pietri, S. Mitra, T. Sadecki, W. Ren, Rocco Romano, John D. Scott, J. Z. Wang, S. Grunewald, R. Prasanna, R. Cotesta, R. G. Ormiston, S. Kaufer, Rainer Weiss, David E. McClelland, Paul J. Groot, M. Zevin, R. A. Mercer, S. Ossokine, Jinsook Kim, Rebecca Fisher, J. Li, A. M. Holgado, H. Fair, Samaya Nissanke, X. Liu, M. A. Bizouard, K. Bossie, John Veitch, J. Lehmann, Al Imran Malik, K. G. Arun, J. D. Tasson, C. K. Cheong, J. R. Gair, M. Fitz-Axen, B. K. Berger, S. D'Antonio, N. Arnaud, K. E. Ramirez, W. Z. Korth, Daniel E. Holz, F. Di Renzo, Torrey Cullen, B. J. J. Slagmolen, Archana Pai, F. Paoletti, Vijay Varma, M. MacInnis, Marco Romanelli, M. Fyffe, F. Cipriano, David Blair, C. Fee, Gabriela Gonzalez, F. Aubin, G. Stratta, Jesper Munch, K. R. Corley, A. Mullavey, T. J. N. Nelson, J. Birch, S. Bae, P. Rapagnani, F. J. Raab, D. Tuyenbayev, B. Patricelli, D. S. Wu, Margaret Millhouse, S. Barnum, D. Buskulic, S. G. Gaonkar, E. Coccia, M. E. Zucker, C. Graef, B. A. Weaver, Xiaohui Fan, J. G. Rollins, Richard O'Shaughnessy, B. Barr, M. De Laurentis, D. Ugolini, P. Clearwater, G. Valdes, David Jones, M. R. Ganija, L.-W. Wei, Haixing Miao, G. Bogaert, R. Taylor, P. Popolizio, Koji Arai, Ryan Lynch, A. D. Viets, D. Meacher, E. J. Fauchon-Jones, E. J. Sanchez, S. Ponrathnam, G. A. Prodi, K. L. Dooley, Fangchen Feng, Lisa Barsotti, Kris Ryan, E. A. Quintero, Marco Cavaglia, J.J. Bero, Leo Tsukada, David H. Shoemaker, M. Lormand, D. J. Stops, S. Karki, Anirban Dasgupta, E. Z. Hamilton, R. J. G. Jonker, J. S. H. Lee, T. Dal Canton, J. Warner, R. Passaquieti, D. Verkindt, Mairi Sakellariadou, G. Pillant, S. H. R. Yuen, Keith Rose, K. S. Karvinen, F. Martelli, C. Rajan, Pablo Cerdá-Durán, Peter R. Saulson, V. Sequino, Tenglin Li, R. DeSalvo, D. Estevez, B. Pang, Paul T. Baker, O. V. Palashov, Sean T. McWilliams, D. Rosińska, J. C. Barayoga, V. Fafone, R. Tso, Jonathan Richardson, F. Piergiovanni, Chang-Hwan Lee, N. Sanchis-Gual, N. Radulescu, L. Mereni, Terry G. McRae, S. Mastrogiovanni, Richard J. Abbott, L. G. Prokhorov, Patrick M. Koch, S. Antier, S. Banagiri, A. Grant, D. Chatterjee, T. L. Lam, A. Pele, A. Chiummo, Nergis Mavalvala, Alessandro Longo, Richard J. Oram, M. Davier, Jerome Degallaix, François Bondu, F. Badaracco, Sebastian Khan, B. C. Barish, Hartmut Grote, R. J. E. Smith, John A. Clark, Ben Farr, Christophe Collette, Ho-Gyu Lee, G. Losurdo, Luca Gammaitoni, R. Metzdorff, C. J. Perez, B. D. O'Brien, M. K. M. Bader, O. Chaibi, Devon S. Johnson, C. Bradaschia, P. Oppermann, Neil J. Cornish, S. Frasca, M. Di Giovanni, Ik Siong Heng, Kai Staats, F-L. Lin, L. Conti, M. Chaturvedi, S. Márka, Stephen Fairhurst, Carl Blair, Peter Aufmuth, T. Di Girolamo, V. Mangano, A. L. Miller, S. Ghosh, László Á. Gergely, A. Macquet, P. Astone, B. Lantz, Daichi Tsuna, K. Mogushi, P. J. King, J. T. Whelan, S. G. Crowder, J. Feicht, Joey Shapiro Key, J. R. Sanders, António Alves da Silva, Q. Chu, S. V. Angelova, L. Magaña Zertuche, Lili Yang, Laura Cadonati, D. A. Steer, M. Branchesi, Zefeng Zhou, D. Y. T. Pong, L. Kleybolte, E. Massera, F. Wellmann, Edward Seidel, O. E. S. Sauter, J. Woehler, S. Chung, K. S. Phukon, A. Avila-Alvarez, Chad Hanna, A. Bramley, C. Kimball, J. Oberling, M. Pirello, K. Gill, Walter Winkler, A. S. Markosyan, Harald Lück, J. Bidler, M. Cho, G. Gaur, S. C. McGuire, J. F. Read, F. Nocera, C. Zhao, Alicia M. Sintes, S. Di Pace, K. Haris, T. Zhang, N. Demos, Thibaut Jacqmin, T. Regimbau, I. Maksimovic, G. Hemming, S. M. Koehlenbeck, M. Saleem, M. Oliver, Douglas Davis, Geraint Pratten, E. Goetz, Tarun Souradeep, Andrea Taracchini, D. Bersanetti, G. Ashton, S. Penn, J. V. van Heijningen, Yu Wang, F. Thies, G. L. Mansell, V. Dattilo, Edwin J. Son, Eric Thrane, Stefan Hild, Y. Ma, A. Brillet, C. Michel, M. Vardaro, Sarah Caudill, T. D. Knowles, F. Robinet, V. B. Adya, J. K. Wofford, F. Cleva, M. P. Ross, T. B. Edo, M. Pichot, Maximiliano Isi, E. M. Gretarsson, Ying Guo, D. Beniwal, Peter Fritschel, Wenxiao Wang, M. Masso-Reid, S. Kwang, L. E. Sanchez, Enrico Calloni, G. Traylor, Thomas Corbitt, L. Salconi, C. A. Costa, Zhihui Du, Laboratoire des matériaux avancés (LMA), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), (Astro)-Particles Physics, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)
Subjects: Physics, [PHYS]Physics [physics], 010504 meteorology & atmospheric sciences, Gravitational wave, Astronomy, Astronomy and Astrophysics, 01 natural sciences, LIGO, Supernova, Fomalhaut, Space and Planetary Science, 0103 physical sciences, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], 010303 astronomy & astrophysics, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences
Abstract: Equation (5) of the published article?(Abbott et al. 2019) is in error; it should read (Formula Presented) The upper limits on ò presented in the published article are unaffected by this error.
Published: 2021
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30. Laparoscopic treatment of deep endometriosis with a diode laser: our experience

Author: Alessandro Pontis, Angelos Daniilidis, Felice Sorrentino, Stefano Angioni, Maurizio Nicola D'Alterio, Raffaele Tinelli, Luigi Nappi, and Michele Peiretti
Subjects: Laparoscopic surgery, Quality of life, Adult, medicine.medical_specialty, medicine.medical_treatment, Endometriosis, law.invention, Young Adult, Pelvic pain, Randomized controlled trial, law, Pregnancy, medicine, Humans, Retrospective Studies, Surgical treatment, business.industry, Chronic pain, Obstetrics and Gynecology, Retrospective cohort study, General Medicine, Diode laser, Deep endometriosis, medicine.disease, Surgery, Dissection, Rectal Diseases, Treatment Outcome, Female, Laparoscopy, medicine.symptom, General Gynecology, Lasers, Semiconductor, business
Abstract: PurposeTo evaluate whether laparoscopic treatment with a diode laser is feasible, safe, and effective in symptomatic patients affected by deep endometriosis (DE).MethodsThis retrospective study was performed using medical record data. The surgical reports, chronic pain scores, and quality of life (QoL) data were evaluated for 50 patients who had undergone laparoscopic surgery between November 2017 and March 2019 at two university hospitals (Monserrato (CA) and Foggia, Italy). Indications for surgery were chronic pelvic pain and/or infertility in patients who wished to conceive spontaneously. Endometriosis lesions/nodules were excised using a diode laser (Leonardo®, Biolitec® DUAL 45) that can combine 980 and 1470 nm wavelengths transmitted through a 1000 µm conical optical fibre.ResultsThe median patient age was 32 years (range 21–44), with a body mass index (BMI) mean of 21.7 ± 2.9 kg/m2. The mean operation time was 147 min (range 106–190). No intraoperative or early complications (p ConclusionThe diode laser confirmed its feasibility and safety for treating endometriosis. During the shaving surgical procedure, the diode laser system ensures a safe and effective laparoscopic dissection of deep endometriotic lesions. Further comprehensive randomized trials are necessary to confirm these preliminary data in terms of efficacy, recurrence rates, and pregnancy outcomes.
Published: 2021

31. Reduced prevalence of fetal exposure to alcohol in Italy: a nationwide survey

Author: La Maida, Nunzia, Di Giorgi, Alessandro, Pellegrini, Manuela, Ceccanti, Mauro, Caruso, Salvatore, Ricci, Giuseppe, Neri, Isabella, Lana, Sheherazade, Minutillo, Adele, Berretta, Paolo, Busardò, Francesco Paolo, Pichini, Simona, Franco, Camandona, Lucia, Vaccari, Laura, Travan, Giampaolo, Maso, Tamara, Stampalija, Lucia, Zanazzo, Paola, Pisana, Lorenza, Driul, Elisa, Barbui, Claudia, Caissutti, Valente, Elena, Alba, Ricchi, Elisa, Bettiga, Elisa, Piccolo, Mariangela, Pati, Simona, Pedori, Patrizio, Antonazzo, Gilda, Sottile, Fabrizio Lo Faro, Anastasio, Tini, Mario, Massacesi, Carmen, Rapisarda, Gabriella, Vivirito, Giampiero, Pinna, Mariarosa, D'Anna, Lili, Klein, Antonino, Bucolo, Rosario, D'Anna, Caterina, Monaco, Giuseppe La Ferrera, Giampiero, Capobianco, Mauro Giorgio Olzai, Stefano, Angioni, Maurizio Nicola D'Alterio, Paolo, Serravalle, Christine, Vicquéry, Sabrina, Scalchi, Carla, Morando, Margherita, Meneghin, Cinzia, Scapolan, Tiziano, Maggino, Barbara, Guarinoni, Giovanna, M Cristina Napolitano, Maria Grazia De Vita, Costantino Di Carlo, Fabiana, Interlandi, Massimo, Bisceglia, Michelangelo, Barbaglia, Alberto, Arnulfo, Enrico, Finale, Luca, Marozio, Ilaria, Natali, Signoretti Maria Grazia, Alex, Staffler, Luigi, Tarani, Giovanna, Coriale, Marisa Patrizia Messina, Alessio, D'Angelo, Marco, Bonito, Cristina, Haass, Letizia, Capasso, Francesco, Raimondi, Giuseppe De Bernardo, Pietro, Iacobelli, Simona, Spadarella, Enrica, Mastantuoni, Raffaello, Rabuano, Francesco, Calzatini, Anna, Bossi, Aversa, Salvatore, Prefumo, Federico, Cristina, Bellan, Giovanna, Leone, Massimo, Ciammella, Silvia, Von-Wunster, Antonella, Liguori, Sara, Ornaghi, Fumagalli, Simona, Fabio, Sanguineti, Gaia, Gianola, Angelo, Cagnacci, Arianna, Amidani, Antonio, Sisto, Francesca Di Marcello, Vincenzo, Santillo, Cristina Di Bartolomeo, Sandro, Gerli, Giacomo, Cagnoli, Mirella, Petrisano, Simona, Pesce, Nicola Di Lascio, Sonia, Falvino, Petronilla, Appio, Vincenza, Targiani, Anna Franca Cavaliere, Irene, Turrini, Gilda, Belli, Beatrice, Gambi, Pasquale, Florio, Elena Degli Innocenti, Letizia, Magi, Flavio, Civitelli, Luigi, Nappi, Felice, Sorrentino, Teresa, Silvestris, Flavia, Indrio, Nicola, Laforgia, Valentina, Rizzo, Maria La Rocca, Ugo, Pradal, Luigi, Memo, Claudio, Diaz, Patrizia, Riscica, and Stefania, Bazz
Subjects: Obstetrics and Gynecology, General Medicine
Published: 2023
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32. Impact of anxiety levels on the perception of pain in patients undergoing office hysteroscopy

Author: Francesco D'Antonio, Raffaele Tinelli, Luigi Nappi, Melania Severo, Annamaria Petito, Felice Sorrentino, Stefano Angioni, and Maria Cristina Solazzo
Subjects: medicine.medical_specialty, Psychometrics, Office Visits, media_common.quotation_subject, Perceived Stress Scale, Pain, Hysteroscopy, Anxiety, Stress, Perception, Surveys and Questionnaires, medicine, Pain perception, Humans, In patient, Vas score, media_common, Pain Measurement, medicine.diagnostic_test, business.industry, Obstetrics and Gynecology, Pain Perception, General Medicine, Middle Aged, Ambulatory, Physical therapy, Female, medicine.symptom, General Gynecology, VAS, business
Abstract: Objective This study aimed at assessing the impact of anxiety on pain perception during hysteroscopy and to highlight the possible contribution of factors related to pain perception. Materials and methods 104 women with indication for office hysteroscopy fullfilled anonymous self-report questionnaires during the waiting time, before the procedure. The first self-report questionnaire included general patient information and an overall assessment of the degree of satisfaction with the information received before the procedure. The level of pre-procedural anxiety was measured through the State-Trait Anxiety Inventory STAI-Y1 (state anxiety). The perceived stress was assessed using the Perceived Stress Scale (PSS). The intensity of pain during the procedure and 20 min later was assessed with VAS score. Results The average waiting time was of 192.33 ± 91 min. 59 patients (56.7%) performed the examination without analgesia while 45 women (43.3%) required analgesia. 28 women (27%) experienced mild pain, 34 (33%) moderate pain and 42 (40%) severe pain. The patients who performed the procedure without analgosedation had an average STAI-Y1 score of 44.81 ± 1.20, compared to women who required analgosedation (average score of 49.40 ± 1.64). The perceived level of stress was also associated with the use of analgosedation. Patients who did not request any anesthetic intervention obtained a PSS average score of 16.66 ± 0.75, compared to the subgroup with anesthesia (score of 19.76 ± 0.90). Conclusions Anxiety represents a key element for the success of ambulatory hysteroscopy. The management of anxiety can reduce the request for analgesia with a consequent optimization of time, costs and safety.
Published: 2020

33. Pathophysiology of hypoxic–ischemic encephalopathy: a review of the past and a view on the future

Author: Francesco D'Antonio, Felice Sorrentino, Giulia Nencini, Carlo Alberto Volta, Francesca Greco, I Cocco, I Piva, Gloria Bonaccorsi, Savino Spadaro, Luigi Nappi, Margherita Neri, M Scioscia, and Pantaleo Greco
Subjects: Male, Pediatrics, medicine.medical_specialty, Neurology, Encephalopathy, Excitotoxicity, medicine.disease_cause, Hypoxic Ischemic Encephalopathy, NO, Hypoxic–ischemic encephalopathy, Neonatal brain, Oxidative stress, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, 030212 general & internal medicine, Asphyxia Neonatorum, business.industry, Incidence (epidemiology), Infant, Newborn, General Medicine, Hypothermia, medicine.disease, Pathophysiology, Hypoxia-Ischemia, Brain, Female, Neurology (clinical), medicine.symptom, business, 030217 neurology & neurosurgery
Abstract: Hypoxic-ischemic encephalopathy, also referred as HIE, is a type of brain injury or damage that is caused by a lack of oxygen to the brain during neonatal period. The incidence is approximately 1.5 cases per 1000 live births in developed countries. In low and middle-income countries, the incidence is much higher (10‒20 per 1000 live births). The treatment for neonatal HIE is hypothermia that is only partially effective (not more than 50% of the neonates treated achieve an improved outcome). HIE pathophysiology involves oxidative stress, mitochondrial energy production failure, glutaminergic excitotoxicity, and apoptosis. So, in the last years, many studies have focused on peptides that act somewhere in the pathway activated by severe anoxic injury leading to HIE. This review describes the pathophysiology of perinatal HIE and the mechanisms that could be the target of innovative HIE treatments.
Published: 2020
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34. Obstetric outcomes in pregnant COVID-19 women: the imbalance of von Willebrand factor and ADAMTS13 axis

Author: Elvira Grandone, Antonella Vimercati, Felice Sorrentino, Donatella Colaizzo, Angelo Ostuni, Oronzo Ceci, Manuela Capozza, Giovanni Tiscia, Antonio De Laurenzo, Mario Mastroianno, Filomena Cappucci, Lucia Fischetti, Maurizio Margaglione, Ettore Cicinelli, and Luigi Nappi
Subjects: Adult, Academic Medical Centers, Adolescent, SARS-CoV-2, Thrombotic Microangiopathies, Obstetrics and Gynecology, ADAMTS13 Protein, COVID-19, Middle Aged, Pregnancy Complications, Tertiary Care Centers, Young Adult, Italy, Pregnancy, von Willebrand Factor, Humans, Premature Birth, Female, Biomarkers
Abstract: Background Thrombotic microangiopathy has been invoked as one of the most important mechanisms of damage in COVID-19 patients. Protease ADAMTS13 is a marker of microangiopathy responsible for controlling von Willebrand multimers size. Von Willebrand factor/ADAMTS13 ratio has been found impaired in COVID-19 patients outside pregnancy. Methods We prospectively investigated 90 pregnant women admitted to two tertiary academic hospitals in Italy with a laboratory-confirmed diagnosis of SARS-CoV-2 infection. Demographic, clinical information and routine laboratory data were collected at the hospital admission and until discharge. We investigated whether vonWillebrand /ADAMTS13 axis imbalance is a predictor of adverse outcomes. Logistic regression analysis, which controlled for potential confounders, was performed to evaluate the association between laboratory parameters and clinical outcomes. Results Most women (55.6%) were parae, with median gestational age at admission of 39 weeks. At hospital admission, 63.3% were asymptomatic for COVID-19 and 24.4% showed more than one sign or symptom of infection. Nulliparae with group O showed Willebrand / ADA MTS-13 ratios significantly lower than non-O, whereas in multiparae this difference was not observed. Logistic regression showed that ratio von Willebrand to ADAMTS13 was significantly and independently associated with preterm delivery (OR 1.9, 95%CI 1.1–3.5). Conclusion This study shows an imbalance of vonWillebrand /ADAMTS13 axis in pregnant women with COVID-19, leading to a significantly higher and independent risk of preterm delivery. Monitoring these biomarkers might support decision making process to manage and follow-up pregnancies in this setting.
Published: 2021

35. Postcoital Vaginal Perforation and Evisceration in Women with No Prior Pelvic Surgery: Laparoscopic Management and Systematic Review of the Literature

Author: Guglielmo Stabile, Giuseppe Ricci, Nicolò de Manzini, Felice Sorrentino, Luigi Nappi, Federico Romano, Francesco Paolo Mangino, Stefania Carlucci, Denise Mordeglia, Stabile, G., Mordeglia, D., Romano, F., Carlucci, S., Mangino, F. P., Nappi, L., Sorrentino, F., De Manzini, N., and Ricci, G.
Subjects: medicine.medical_specialty, Health, Toxicology and Mutagenesis, medicine.medical_treatment, Vaginal Diseases, vaginal perforation, MEDLINE, laparoscopy, Review, Disease, Sexual intercourse, Evisceration, Vaginal perforation, medicine, Humans, Postcoital, Surgical emergency, Laparoscopy, Evisceration (ophthalmology), Rupture, medicine.diagnostic_test, business.industry, General surgery, Vaginal rupture, evisceration, Coitus, Public Health, Environmental and Occupational Health, sexual intercourse, postcoital, medicine.anatomical_structure, Vaginal fornix, vaginal rupture, Medicine, Female, business
Abstract: Objective: to evaluate risk factors, causes, management and surgical therapy of postcoital vaginal perforation and evisceration in women with no prior pelvic surgery. Data sources: We used MEDLINE (PubMed), Scopus, Embase and Web of Science for our research. Our review includes all reports from 1980 to November 2020. The research strategy adopted included different combinations of the following terms: (intercourse) AND (coitus) AND (vaginal perforation). Methods of study selection: we report a case of vaginal evisceration after consensual intercourse in a young and healthy woman. In addition, we performed a systematic review of vaginal perforations with or without evisceration in women without prior surgery or any other predisposing disease. All studies identified were listed by citation, title, authors and abstract. Duplicates were identified by an independent manual screening, performed by one researcher and then removed. For the eligibility process, two authors independently screened the title and abstracts of all non-duplicated papers and excluded those not pertinent to the topic. Tabulation, integration and results: We have followed the PRISMA guidelines. Five manuscripts were detected through the references of the works that had been identified with the research on MEDLINE (PubMed), Scopus, Embase and Web of Science. We found 16 cases between 1980 and 2020. The young age and the virginal status represent the principal risk factors and all the lacerations occurred in the posterior vaginal fornix. The most common surgical technique was the laparotomic approach and, in the remaining cases, the laparoscopic and vaginal route was performed. Conclusions: Post-coital vaginal perforation and evisceration in women with no prior pelvic surgery is a rare condition in the clinical practice and, when it is associated with evisceration it is a surgical emergency. Usually, these injuries are not life-threatening conditions but, a delay in diagnosis, can lead to severe complications. In consideration of the high heterogeneity of the data in the literature, it is essential to define a diagnostic–therapeutic management for the patients with vaginal perforation. With our review, we try to identify the associated risk factors, the best and fastest diagnosis, and the best surgical approach. We believe that a combined vaginal and laparoscopic approach can be the best surgical treatment, useful to diagnose injuries of the abdominal organs and to improve postoperative outcome.
Published: 2021

36. Differential diagnosis of adenomyosis: the role of hysteroscopy and laparoscopy

Author: Felice Sorrentino, L. Nappi, Alessandro Pontis, and Stefano Angioni
Subjects: medicine.medical_specialty, Reproductive Medicine, medicine.diagnostic_test, Hysteroscopy, business.industry, medicine, Obstetrics and Gynecology, Adenomyosis, Radiology, Differential diagnosis, business, Laparoscopy, medicine.disease
Published: 2019
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37. Interstitial Pregnancy Treated with Mifepristone and Methotrexate with High Serum β-hCG Level in a Patient Wishing to Preserve Fertility: Time to Define Standardized Criteria for Medical/Surgical Therapy?

Author: Felice Sorrentino, Lorenzo Vasciaveo, Vincenzo De Feo, Erika Zanzarelli, Elvira Grandone, Guglielmo Stabile, and Luigi Nappi
Subjects: Health, Toxicology and Mutagenesis, Public Health, Environmental and Occupational Health
Abstract: Interstitial pregnancy (IP) accounts for 2% of all ectopic pregnancies and has a mortality rate of 2–2.5%. The diagnosis is made by a transvaginal ultrasound and the treatment can be medical or surgical. We report the case of a 36-year-old primigravida who was 6 + 5 weeks pregnant, diagnosed with interstitial pregnancy by ultrasound, who had a very high serum β-hCG level (31,298 mIU/mL) and wanted to preserve her fertility. The patient was treated with one dose of mifepristone and a double dose of methotrexate since the decrease in the β-hCG serum level was less than 15% after the first dose. At the beginning, medical therapy was effective, as no embryonal cardiac activity was detected and serum β-hCG levels decreased early, but on the 20th day of hospitalization, the patient underwent surgery for her clinical symptoms and the evidence of free fluid in the Douglas pouch at a transvaginal ultrasound exam. Our experience showed that medical treatment should be considered, especially in women wishing to preserve their fertility. Further studies are needed to establish a standardized protocol and maybe a clinical score that can be useful in predicting the patients in which medical therapy could be most successful.
Published: 2022
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38. Endometriosis and adverse pregnancy outcome

Author: Maristella De Padova, Maurizio Nicola D'Alterio, Maddalena Falagario, Felice Sorrentino, Luis Alonso Pacheco, Attilio Di Spiezio Sardo, J. Carugno, and Luigi Nappi
Subjects: Infertility, medicine.medical_specialty, Oral contraceptive pill, Endometriosis, Disease, Miscarriage, Pregnancy, medicine, Humans, Obstetrics, business.industry, Cesarean Section, Pelvic pain, Infant, Newborn, Pregnancy Outcome, Obstetrics and Gynecology, medicine.disease, United States, Placenta previa, Abortion, Spontaneous, Premature Birth, Female, medicine.symptom, business
Abstract: Endometriosis is a gynecologic disease affecting approximately 10% of reproductive age women, around 21-47% of women presenting subfertility and 71-87% of women with chronic pelvic pain. Main symptoms are chronic pelvic pain, dysmenorrhea, dyspareunia and infertility that seem to be well controlled by oral contraceptive pill, progestogens, GnRh antagonists. The aim of this review was to illustrate the modern diagnosis of endometriosis during pregnancy, to evaluate the evolution of endometriotic lesions during pregnancy and the incidence of adverse outcomes.Published literature was retrieved through searches of the database PubMed (National Center for Biotechnology Information, US National Library of Medicine, Bethesda, MD, USA). We searched for all original articles published in English through April 2020 and decided to extract every notable information for potential inclusion in this review. The search included the following MeSH search terms, alone or in combination: "endometriosis" combined with "endometrioma," "biomarkers," "complications," "bowel," "urinary tract," "uterine rupture," "spontaneous hemoperitoneum in pregnancy" and more "adverse pregnancy outcome," "preterm birth," "miscarriage," "abruption placentae," "placenta previa," "hypertensive disorder," "preeclampsia," "fetal grow restriction," "small for gestation age," "cesarean delivery."Pregnancy in women with endometriosis does not always lead to disappearance of symptoms and decrease in the size of endometriotic lesions, but it may be possible to observe a malignant transformation of ovarian endometriotic lesions. Onset of complications may be caused by many factors: chronic inflammation, adhesions, progesterone resistance and a dysregulation of genes involved in the embryo implantation. As results, the pregnancy can be more difficult because of endometriosis related complications (spontaneous hemoperitoneum [SH], bowel complications, etc.) or adverse outcomes like preterm birth, FGR, hypertensive disorders, obstetrics hemorrhages (placenta previa, abruptio placenta), miscarriage or cesarean section. Due to insufficient knowledge about its pathogenesis, currently literature data are contradictory and do not show a strong correlation between endometriosis and these complications except for miscarriage and cesarean delivery.Future research should focus on the potential biological pathways underlying these relationships in order to inform patients planning a birth about possible complications during pregnancy.
Published: 2021

39. Role of surgical treatment in endometriosis

Author: Felice Sorrentino, Stefania Saponara, Margherita Russo, Gianmarco D'Ancona, Stefano Angioni, Luigi Nappi, Maurizio Nicola D'Alterio, and Antonio Simone Laganà
Subjects: Pregnancy, medicine.medical_specialty, Ovarian cyst, business.industry, Pelvic pain, General surgery, Endometriosis, Obstetrics and Gynecology, Context (language use), Disease, medicine.disease, Pelvic Pain, Pelvis, medicine.anatomical_structure, Medicine, Humans, Female, Laparoscopy, Presentation (obstetrics), medicine.symptom, Peritoneum, business
Abstract: Endometriosis can take one of three forms depending on its clinical presentation and management: endometriotic ovarian cyst (ovarian endometrioma), superficial or peritoneal endometriosis and deep infiltrating endometriosis (DIE).1Among them, DIE is considered the most aggressive, and the patient is often affected by more than one type together. The therapeutic methodology should not be influenced by a combination of different types of endometriotic lesion. According to the clinical context and the patient's needs, the treatment of this pathology can be medical or surgical. Although medical therapy could improve endometriosis-associated symptoms, it never offers a definite treatment for symptomatic patients, who often require surgical treatment. The rationale behind endometriosis surgical treatment is to achieve the complete removal of all lesions through a one-step surgical procedure; to obtain promising long-term results for pelvic pain, recurrence rate, and fertility; and to protect the functionality of the involved organs. Achieving these results depends on the total removal of the pathology from the pelvis, in an attempt to preserve, as much as possible, the healthy tissues surrounding the site of the disease. The choice of a surgical approach rather than medical therapy is subject to the patient's expectations, such as pregnancy desire, the effectiveness of treatment compared to possible complications, the type of pain and its intensity, and the location and severity of the disease. In this context, surgical management using a multidisciplinary endometriosis team is an important factor for achieving good outcomes.
Published: 2021

40. Fertility outcomes after hysteroscopic removal of intrauterine leiomyomas and polyps

Author: Maria Chiara De Angelis, Jose Carugno, Felice Sorrentino, Alfonso Manzi, Attilio Di Spiezio Sardo, and Luigi Nappi
Subjects: medicine.medical_specialty, media_common.quotation_subject, Fertility, Hysteroscopy, Endometrium, law.invention, Polyps, Randomized controlled trial, law, Pregnancy, medicine, Endometrial Polyp, Humans, media_common, Uterine Diseases, medicine.diagnostic_test, Leiomyoma, Obstetrics, business.industry, Obstetrics and Gynecology, medicine.disease, medicine.anatomical_structure, Female, Uterine cavity, business, Infertility, Female, Evidence synthesis
Abstract: Introduction Thanks to the progress of science, it is now understood that a successful implantation not only depends on the quality of the embryo, but also on having a receptive endometrium. During the years, several authors have reviewed the important role of the uterine factor, ranging from the congenital anomalies, such as uterine septa and subsepta, and acquired conditions such as endometrial polyps and submucous myomas. Currently, hysteroscopy has proved to be a powerful and accurate tool for visualizing the uterine cavity and treating intrauterine pathologies. Evidence acquisition This review of the literature aims to report the current available data on the effects of the two most common endouterine pathologies (i.e. endometrial polyps and submucous myomas) and the impact of hysteroscopic removal on fertility outcomes. Evidence synthesis To date, the low number of randomized controlled trials available does not yet make it possible to give a definitive answer on what are the reproductive outcomes following treatment of endometrial polyps and leiomyomas. Nevertheless, existing evidence points to a benefit of removal of this two pathologies in infertile women, mostly when they have a history of recurrent pregnancy loss. Conclusions Further studies are needed to demonstrate that surgical treatments of endometrial polyps and myomas could improve not only the morphology but also the function of the uterine cavity before undergoing any assisted fertility treatment.
Published: 2021

41. Pregnancy outcomes in women with polycystic ovarian syndrome

Author: Antonio G. Succu, Valeria Ghisu, Felice Sorrentino, Marco Sigilli, Luigi Nappi, Stefano Angioni, Maurizio Nicola D'Alterio, Raffaele Tinelli, and Antonio Simone Laganà
Subjects: Adult, medicine.medical_specialty, endocrine system diseases, Birth weight, Population, Preeclampsia, Pregnancy, Risk Factors, medicine, Humans, education, education.field_of_study, business.industry, Obstetrics, Cesarean Section, Hyperandrogenism, Infant, Newborn, Pregnancy Outcome, Obstetrics and Gynecology, Gestational age, medicine.disease, female genital diseases and pregnancy complications, Gestational diabetes, Small for gestational age, Premature Birth, Female, business, Polycystic Ovary Syndrome
Abstract: Polycystic ovarian syndrome (PCOS) is the most common endocrinological disease of reproductive-aged women, with an estimated incidence ranging from 5% to 15%. The clinical manifestations of PCOS are heterogeneous and vary according to the age of the patient. Insulin resistance (IR), hyperandrogenism, and obesity are widely assumed to play a pivotal role in the pathophysiological mechanism of PCOS. As previously stated by many conducted meta-analyses, PCOS can cause a rising risk of pregnancy complications, including maternal, fetal, and neonatal complications. Pregnancy-induced hypertension (PIH), preeclampsia (PE), gestational diabetes mellitus (GDM), spontaneous preterm birth (PTB), and an increased necessity for a cesarean section (CS) are the most documented maternal implications. Regarding fetal outcomes, PCOS has also been correlated with elevated neonatal morbidity, prematurity, fetal growth restriction (FGR), birth weight variations (large for gestational age (LGA) and small for gestational age (SGA), and transfer to the neonatal intensive care unit (NICU). Owing to the variability of the studies performed, the association of PCOS with an elevated risk of adverse pregnancy outcomes is still controversial. This variability is found in the diagnosis and clinical presentations of PCOS, and can be influenced by pre-pregnancy circumstances and therapies as well as particular population and environmental features. The Amsterdam consensus guidelines confirm that obesity and IR can worsen maternal and fetal complications; thus, a closer follow-up should be offered to PCOS women during pregnancy.
Published: 2021

42. Possible role of microbiome in the pathogenesis of endometriosis

Author: Germano Orrù, Carlotta Giuliani, Felice Sorrentino, Francesco Scicchitano, Maurizio Nicola D'Alterio, Stefano Angioni, Antonio Simone Laganà, Noemi M Oltolina, and Luigi Nappi
Subjects: business.industry, Microbiota, Endometriosis, Obstetrics and Gynecology, medicine.disease, Bioinformatics, Pathogenesis, Cohort Studies, Medicine, Animals, Humans, Female, Microbiome, Electronic database, business, Animal species, Evidence synthesis, Systematic search
Abstract: Introduction There is an urgent necessity to explore the complex pathophysiological nature of endometriosis, which may enable the rationale for new diagnostic and therapeutic strategies to be discovered. This systematic review aimed to clarify the bidirectional relationship between endometriosis and the microbiome and evaluate if the microbiome may be involved in endometriosis's pathogenesis, establishing a potential connection between the different studies. Evidence acquisition Studies were identified through a systematic literature search of papers that evaluated the microbiomes of human or other animal species with endometriosis and of those without in the electronic database PubMed/Medline, and Embase without a date restriction. We included all cohort studies focusing on the interaction between endometriosis and the microbiomes of humans or other mammals, evaluating if the microbiome may be involved in endometriosis's pathogenesis. Evidence synthesis Endometriosis appears to be associated with elevated levels of different microorganisms across various microbiome sites. An ineffective immune response seems to play a key role in endometriosis pathogenesis, and there is some scientific proof to state that the immune response may be modulated by the microbiome. Interestingly, nine studies of our review detected species belonging to the phyla Proteobacteria, Bacteroidetes, and Negativicutes characterized by Gram-negative staining, that were significantly increased in endometriosis cohorts. Conclusions Laboratory and clinical investigations indicate that hosts' microbiome profiles with and without endometriosis can be significantly different. To further our understanding of the relationships between endometriosis and the host microbiome, more studies are necessary.
Published: 2021

43. Systematic review and meta-analysis of genetic association studies of pelvic organ prolapse

Author: Marianne Koch, Rufus Cartwright, Romana Cuffolo, Felice Sorrentino, John W F Chua, Kristina Allen-Brady, and Medical Research Council (MRC)
Subjects: Urology, VARIANT, 030232 urology & nephrology, HAPLOTYPE, SUSCEPTIBILITY, Bioinformatics, Pelvic Organ Prolapse, ALPHA-1 POLYMORPHISM, 03 medical and health sciences, 0302 clinical medicine, Genetic etiology, Prolapse, Genetics, Humans, Medicine, Obstetrics & Reproductive Medicine, Genetic Association Studies, LAMININ GAMMA-1, Genetic association, Genetic testing, Pelvic organ, 030219 obstetrics & reproductive medicine, Science & Technology, medicine.diagnostic_test, business.industry, Obstetrics and Gynecology, Obstetrics & Gynecology, WOMEN, Urology & Nephrology, Random effects model, Twin study, Meta-analysis, ESTROGEN-RECEPTOR, INCONTINENCE, FBLN5, RISK-FACTORS, MUTATION SCREEN, 1114 Paediatrics and Reproductive Medicine, Original Article, business, Life Sciences & Biomedicine
Abstract: Introduction and hypothesis Family and twin studies demonstrate that pelvic organ prolapse (POP) is heritable, but the genetic etiology is poorly understood. This review aimed to identify genetic loci and specific polymorphisms associated with POP, while assessing the strength, consistency, and risk of bias among reported associations. Methods Updating an earlier systematic review, PubMed and HuGE Navigator as well as relevant conference abstracts were searched using genetic and phenotype keywords from 2015 to 2020. Screening and data extraction were performed in duplicate. Fixed and random effects meta-analyses were conducted using co-dominant models of inheritance. We assessed credibility of pooled associations using interim Venice criteria. Results We screened 504 new abstracts and included 46 published and 7 unpublished studies. In pooled analyses we found significant associations for four polymorphisms: rs2228480 at the ESR1 gene (OR 0.67 95% CI 0.46–0.98, I2 = 0.0%, Venice rating BAB), rs12589592 at the FBLN5 gene (OR 1.46 95% CI 1.11–1.82, I2 = 36.3%, Venice rating BBB), rs484389 in the PGR gene (OR 0.61 95% CI 0.39–0.96, I2 = 32.4%, Venice rating CBB), and rs1800012 at the COL1A1 gene (OR 0.80 95% CI 0.66–0.96, I2 = 0.0%, Venice rating BAB). Further credible novel variants have also been recently identified in genome-wide association studies. Conclusion The genetic contributions to POP remain poorly understood. Several biologically plausible variants have been identified, but much work is required to establish the role of these genes in the pathogenesis of POP or to establish a role for genetic testing in clinical practice.
Published: 2021

44. Risk factors associated with adverse fetal outcomes in pregnancies affected by Coronavirus disease 2019 (COVID-19): a secondary analysis of the WAPM study on COVID-19

Author: Eran Hadar, Chiara Benedetto, Agnese Maria Chiara Rapisarda, Renato Augusto Moreira de Sá, Deena Elkafrawi, Daniela Luvero, Noa A Brzezinski Sinai, Alicia Martínez-Varea, Antonio Schiattarella, Anna Nunzia Della Gatta, Giovanni Scambia, Albert Lila, Luciano Di Tizio, Andrea Carosso, Giovanni Nazzaro, G. Schera, Giuseppe Rizzo, Giuseppe Maria Maruotti, Giusella D'Urso, Albaro José Nieto-Calvache, Ilenia Mappa, Ozlem Uyaniklar, Fabio Barra, Gilles Faron, Luigi Nappi, Jacopo Ferrari, Giulio Sozzi, Simone Ferrero, Mirjam Druškovič, Tanja Premru-Srsen, Leonardo Borrello, Fabiana Cecchini D, George Daskalakis, Giuliano Petriglia, Caroline Kadji, Felipe Mercado-Olivares, Zeliha Atak, Aylin Pelin Cil, Claudio Gustavino, Axelle Pintiaux, Pantaleo Greco, Rita Figueiredo, Stefano Cosma, Ludovica Puri, Valentina Esposito, Anupam Parange, Simone Garzon, Alessandra Gatti, Ioannis Kyvernitakis, Roberto Brunelli, Maddalena Morlando, Attilio Di Spiezio Sardo, Ignacio Cueto Hernández, Giuseppe Zoccali, Brian Rodriguez, Antonio Mollo, Flaminia Vena, Cihat Sen, Ciuhodaru Madalina, Felice Sorrentino, Francesca Di Sebastiano, Gennady T. Sukhikh, Ilma Floriana Carbone, Andrea Villasco, Blanka Zlatohlavkova, Gabriele Saccone, Erasmo Huertas, Marcel Malan, Leonardo Gucciardo, Eutalia Esposito, Otto Henrique May Feuerschuette, Sarah Dollinger, María de Los Angeles Anaya Baz, Jun Yoshimatsu, Sifa Turan, Vincente Diago, Alicia Yeliz Aykanat, Ignacio Herraiz, Javier Alfonso Schvartzman, Diego Gazzolo, Natalina Buono, Milan Stanojević, Erich Cosmi, Valentina De Robertis, Elena Costa, Angelo Cagnacci, Eleonora Valori, Nicoletta Biglia, Şerife Özlem Genç, Vincenzo Berghella, Francesco Maria Colaleo, Esther Vanessa Aguilar Galán, Gabriela Loscalzo, Marco Palumbo, Fabrizio Sandri, Irmeli Nupponen, Antonio Lanzone, Juan Antonio De León Luis, Amos Grunebaum, Giuseppe Bifulco, Marinella Lenzi, Serena Xodo, Fulvio Zullo, Ozhan Turan, Josefine Königbauer, Anna Luengo Piqueras, Nicola Volpe, Holger Maul, Chiara Taccaliti, Juan Manuel Burgos-Luna, Giovanni Sisti, Rosanna Esposito, Alfredo Ercoli, Panos Antsaklis, Dolores Esteban Oliva, Aly Youssef, Pedro Viana Pinto, Alberto Galindo, Asim Kurjak, Erhan Okuyan, Roberto Angioli, Maria Luisa Gonzalez-Duran, Ana Concheiro Guisan, Massimo Franchi, Maria Carmela Di Dedda, Giovanni Gerosolima, Francesco D'Antonio, Caroline Daelemans, Quintino Cesare Ianniciello, Pasquale De Franciscis, Maurizio Guida, Maria Cristina Rovellotti, Liana Ples, Frank A. Chervenak, Nicola Colacurci, Lilijana Kornhauser Cerar, Zulfiya Khodjaeva, Valentina Longo, Francesca Stollagli, Daniele Di Mascio, Mariavittoria Locci, Amadeo Sanchez, Angelo Sirico, Stefania Fieni, Rebeca Garrote Molpeceres, Pierluigi Benedetti Panici, Vito Chiantera, Esra Tustas Haberal, Liviu Cojocaru, Maria Elena Flacco, Antonella Cromi, Roberta Granese, Antonio Simone Laganà, Maria Giulia Lombana Marino, Silvia Visentin, Beatrice Bianchi, Roberta Venturella, Federica Laraud, Amanda Bermejo, Reyhan Gündüz, Marina Moucho, Zita Maria Gambacorti-Passerini, Danila Morano, Pedro Arango, Francesca Della Sala, Gaetana Di Donna, Jesús S Jimenez Lopez, Mariano Catello Di Donna, Giuliana Simonazzi, Snezana Zdjelar, Vedran Stefanovic, Cecilia Villalain, Antonio Coviello, Lars Hellmeyer, Antonella Giancotti, Elisa Bevilacqua, Igor Samardjiski, Riccardo Buscemi, Arianna Ramone, Marco Cerbone, Lorenza Driul, Danilo Buca, Tiziana Frusca, Elisa Done, Marco Liberati, José Morales Roselló, Fabio Ghezzi, Lorenzo Vasciaveo, Bernd Froessler, Alejandro Pittaro, Yolanda Cuñarro López, Andrew Carlin, Sakine Rahimli Ocakouglu, Giorgia Gattei, I. Cataneo, María José Suárez, Giada Ameli, Lamberto Manzoli, Kaisa Nelskylä, Ludovico Muzii, Peter Palm, Olus Api, Elisa Cueto, Martina Leombroni, Ksenia A. Gorina, HUS Gynecology and Obstetrics, Department of Obstetrics and Gynecology, Children's Hospital, HUS Children and Adolescents, HUS Perioperative, Intensive Care and Pain Medicine, Anestesiologian yksikkö, Department of Diagnostics and Therapeutics, Dicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı, Gündüz, Reyhan, Di Mascio D., Sen C., Saccone G., Galindo A., Grunebaum A., Yoshimatsu J., Stanojevic M., Kurjak A., Chervenak F., Suarez M.J.R., Gambacorti-Passerini Z.M., De Los Angeles Anaya Baz M., Galan E.V.A., Lopez Y.C., De Leon Luis J.A., Hernandez I.C., Herraiz I., Villalain C., Venturella R., Rizzo G., Mappa I., Gerosolima G., Hellmeyer L., Konigbauer J., Ameli G., Frusca T., Volpe N., Schera G.B.L., Fieni S., Esposito E., Simonazzi G., Di Donna G., Youssef A., Della Gatta A.N., Di Donna M.C., Chiantera V., Buono N., Sozzi G., Greco P., Morano D., Bianchi B., Marino M.G.L., Laraud F., Ramone A., Cagnacci A., Barra F., Gustavino C., Ferrero S., Ghezzi F., Cromi A., Lagana A.S., Longo V.L., Stollagli F., Sirico A., Lanzone A., Driul L., Fabiana Cecchini D., Xodo S., Rodriguez B., Mercado-Olivares F., Elkafrawi D., Sisti G., Esposito R., Coviello A., Cerbone M., Morlando M., Schiattarella A., Colacurci N., De Franciscis P., Cataneo I., Lenzi M., Sandri F., Buscemi R., Gattei G., Della Sala F., Valori E., Rovellotti M.C., Done E., Faron G., Gucciardo L., Esposito V., Vena F., Giancotti A., Brunelli R., Muzii L., Nappi L., Sorrentino F., Vasciaveo L., Liberati M., Buca D., Leombroni M., Di Sebastiano F., Di Tizio L., Gazzolo D., Franchi M., Ianniciello Q.C., Garzon S., Petriglia G., Borrello L., Nieto-Calvache A.J., Burgos-Luna J.M., Kadji C., Carlin A., Bevilacqua E., Moucho M., Pinto P.V., Figueiredo R., Rosello J.M., Loscalzo G., Martinez-Varea A., Diago V., Lopez J.S.J., Aykanat A.Y., Cosma S., Carosso A., Benedetto C., Bermejo A., Feuerschuette O.H.M., Uyaniklar O., Ocakouglu S.R., Atak Z., Gunduz R., Haberal E.T., Froessler B., Parange A., Palm P., Samardjiski I., Taccaliti C., Okuyan E., Daskalakis G., De Sa R.A.M., Pittaro A., Gonzalez-Duran M.L., Guisan A.C., Genc S.O., Zlatohlavkova B., Piqueras A.L., Oliva D.E., Cil A.P., Api O., Antsaklis P., Ples L., Kyvernitakis I., Maul H., Malan M., Lila A., Granese R., Ercoli A., Zoccali G., Villasco A., Biglia N., Madalina C., Costa E., Daelemans C., Pintiaux A., Cueto E., Hadar E., Dollinger S., Sinai N.A.B., Huertas E., Arango P., Sanchez A., Schvartzman J.A., Cojocaru L., Turan S., Turan O., Di Dedda M.C., Molpeceres R.G., Zdjelar S., Premru-Srsen T., Cerar L.K., Druskovie M., De Robertis V., Stefanovic V., Nupponen I., Nelskyla K., Khodjaeva Z., Gorina K.A., Sukhikh G.T., Maruotti G.M., Visentin S., Cosmi E., Ferrari J., Gatti A., Luvero D., Angioli R., Puri L., Palumbo M., D'Urso G., Colaleo F., Rapisarda A.M.C., Carbone I.F., Mollo A., Nazzaro G., Locci M., Guida M., Di Spiezio Sardo A., Panici P.B., Berghella V., Flacco M.E., Manzoli L., Bifulco G., Scambia G., Zullo F., D'Antonio F., Di Mascio D, Sen C, Saccone G, Galindo A, Grünebaum A, Yoshimatsu J, Stanojevic M, Kurjak A, Chervenak F, Rodríguez Suárez MJ, Gambacorti-Passerini ZM, Baz MLAA, Aguilar Galán EV, López YC, De León Luis JA, Hernández IC, Herraiz I, Villalain C, Venturella R, Rizzo G, Mappa I, Gerosolima G, Hellmeyer L, Königbauer J, Ameli G, Frusca T, Volpe N, Luca Schera GB, Fieni S, Esposito E, Simonazzi G, Di Donna G, Youssef A, Della Gatta AN, Di Donna MC, Chiantera V, Buono N, Sozzi G, Greco P, Morano D, Bianchi B, Lombana Marino MG, Laraud F, Ramone A, Cagnacci A, Barra F, Gustavino C, Ferrero S, Ghezzi F, Cromi A, Laganà AS, Laurita Longo V, Stollagli F, Sirico A, Lanzone A, Driul L, Cecchini D F, Xodo S, Rodriguez B, Mercado-Olivares F, Elkafrawi D, Sisti G, Esposito R, Coviello A, Cerbone M, Morlando M, Schiattarella A, Colacurci N, De Franciscis P, Cataneo I, Lenzi M, Sandri F, Buscemi R, Gattei G, Sala FD, Valori E, Rovellotti MC, Done E, Faron G, Gucciardo L, Esposito V, Vena F, Giancotti A, Brunelli R, Muzii L, Nappi L, Sorrentino F, Vasciaveo L, Liberati M, Buca D, Leombroni M, Di Sebastiano F, Di Tizio L, Gazzolo D, Franchi M, Ianniciello QC, Garzon S, Petriglia G, Borrello L, Nieto-Calvache AJ, Burgos-Luna JM, Kadji C, Carlin A, Bevilacqua E, Moucho M, Pinto PV, Figueiredo R, Roselló JM, Loscalzo G, Martinez-Varea A, Diago V, Jimenez Lopez JS, Aykanat AY, Cosma S, Carosso A, Benedetto C, Bermejo A, May Feuerschuette OH, Uyaniklar O, Ocakouglu SR, Atak Z, Gündüz R, Haberal ET, Froessler B, Parange A, Palm P, Samardjiski I, Taccaliti C, Okuyan E, Daskalakis G, Moreira de Sa RA, Pittaro A, Gonzalez-Duran ML, Guisan AC, Genç ŞÖ, Zlatohlávková B, Piqueras AL, Oliva DE, Cil AP, Api O, Antsaklis P, Ples L, Kyvernitakis I, Maul H, Malan M, Lila A, Granese R, Ercoli A, Zoccali G, Villasco A, Biglia N, Madalina C, Costa E, Daelemans C, Pintiaux A, Cueto E, Hadar E, Dollinger S, Brzezinski Sinai NA, Huertas E, Arango P, Sanchez A, Schvartzman JA, Cojocaru L, Turan S, Turan O, Di Dedda MC, Molpeceres RG, Zdjelar S, Premru-Srsen T, Cerar LK, Druškovič M, De Robertis V, Stefanovic V, Nupponen I, Nelskylä K, Khodjaeva Z, Gorina KA, Sukhikh GT, Maruotti GM, Visentin S, Cosmi E, Ferrari J, Gatti A, Luvero D, Angioli R, Puri L, Palumbo M, D'Urso G, Colaleo F, Chiara Rapisarda AM, Carbone IF, Mollo A, Nazzaro G, Locci M, Guida M, Di Spiezio Sardo A, Panici PB, Berghella V, Flacco ME, Manzoli L, Bifulco G, Scambia G, Zullo F, D'Antonio F, Di Mascio, D., Sen, C., Saccone, G., Galindo, A., Grunebaum, A., Yoshimatsu, J., Stanojevic, M., Kurjak, A., Chervenak, F., Suarez, M. J. R., Gambacorti-Passerini, Z. M., De Los Angeles Anaya Baz, M., Galan, E. V. A., Lopez, Y. C., De Leon Luis, J. A., Hernandez, I. C., Herraiz, I., Villalain, C., Venturella, R., Rizzo, G., Mappa, I., Gerosolima, G., Hellmeyer, L., Konigbauer, J., Ameli, G., Frusca, T., Volpe, N., Schera, G. B. L., Fieni, S., Esposito, E., Simonazzi, G., Di Donna, G., Youssef, A., Della Gatta, A. N., Di Donna, M. C., Chiantera, V., Buono, N., Sozzi, G., Greco, P., Morano, D., Bianchi, B., Marino, M. G. L., Laraud, F., Ramone, A., Cagnacci, A., Barra, F., Gustavino, C., Ferrero, S., Ghezzi, F., Cromi, A., Lagana, A. S., Longo, V. L., Stollagli, F., Sirico, A., Lanzone, A., Driul, L., Fabiana Cecchini, D., Xodo, S., Rodriguez, B., Mercado-Olivares, F., Elkafrawi, D., Sisti, G., Esposito, R., Coviello, A., Cerbone, M., Morlando, M., Schiattarella, A., Colacurci, N., De Franciscis, P., Cataneo, I., Lenzi, M., Sandri, F., Buscemi, R., Gattei, G., Della Sala, F., Valori, E., Rovellotti, M. C., Done, E., Faron, G., Gucciardo, L., Esposito, V., Vena, F., Giancotti, A., Brunelli, R., Muzii, L., Nappi, L., Sorrentino, F., Vasciaveo, L., Liberati, M., Buca, D., Leombroni, M., Di Sebastiano, F., Di Tizio, L., Gazzolo, D., Franchi, M., Ianniciello, Q. C., Garzon, S., Petriglia, G., Borrello, L., Nieto-Calvache, A. J., Burgos-Luna, J. M., Kadji, C., Carlin, A., Bevilacqua, E., Moucho, M., Pinto, P. V., Figueiredo, R., Rosello, J. M., Loscalzo, G., Martinez-Varea, A., Diago, V., Lopez, J. S. J., Aykanat, A. Y., Cosma, S., Carosso, A., Benedetto, C., Bermejo, A., Feuerschuette, O. H. M., Uyaniklar, O., Ocakouglu, S. R., Atak, Z., Gunduz, R., Haberal, E. T., Froessler, B., Parange, A., Palm, P., Samardjiski, I., Taccaliti, C., Okuyan, E., Daskalakis, G., De Sa, R. A. M., Pittaro, A., Gonzalez-Duran, M. L., Guisan, A. C., Genc, S. O., Zlatohlavkova, B., Piqueras, A. L., Oliva, D. E., Cil, A. P., Api, O., Antsaklis, P., Ples, L., Kyvernitakis, I., Maul, H., Malan, M., Lila, A., Granese, R., Ercoli, A., Zoccali, G., Villasco, A., Biglia, N., Madalina, C., Costa, E., Daelemans, C., Pintiaux, A., Cueto, E., Hadar, E., Dollinger, S., Sinai, N. A. B., Huertas, E., Arango, P., Sanchez, A., Schvartzman, J. A., Cojocaru, L., Turan, S., Turan, O., Di Dedda, M. C., Molpeceres, R. G., Zdjelar, S., Premru-Srsen, T., Cerar, L. K., Druskovie, M., De Robertis, V., Stefanovic, V., Nupponen, I., Nelskyla, K., Khodjaeva, Z., Gorina, K. A., Sukhikh, G. T., Maruotti, G. M., Visentin, S., Cosmi, E., Ferrari, J., Gatti, A., Luvero, D., Angioli, R., Puri, L., Palumbo, M., D'Urso, G., Colaleo, F., Rapisarda, A. M. C., Carbone, I. F., Mollo, A., Nazzaro, G., Locci, M., Guida, M., Di Spiezio Sardo, A., Panici, P. B., Berghella, V., Flacco, M. E., Manzoli, L., Bifulco, G., Scambia, G., Zullo, F., D'Antonio, F., Di Mascio, Daniele, Sen, Cihat, Saccone, Gabriele, Galindo, Alberto, Grünebaum, Amo, Yoshimatsu, Jun, Stanojevic, Milan, Kurjak, Asım, Chervenak, Frank, Rodríguez Suárez, María José, Gambacorti-Passerini, Zita Maria, Baz, María de Los Angeles Anaya, Aguilar Galán, Esther Vanessa, López, Yolanda Cuñarro, De León Luis, Juan Antonio, Hernández, Ignacio Cueto, Herraiz, Ignacio, Villalain, Cecilia, Venturella, Roberta, Rizzo, Giuseppe, Mappa, Ilenia, Gerosolima, Giovanni, Hellmeyer, Lar, Königbauer, Josefine, Ameli, Giada, Frusca, Tiziana, Volpe, Nicola, Luca Schera, Giovanni Battista, Fieni, Stefania, Esposito, Eutalia, Simonazzi, Giuliana, Di Donna, Gaetana, Youssef, Aly, Della Gatta, Anna Nunzia, Di Donna, Mariano Catello, Chiantera, Vito, Buono, Natalina, Sozzi, Giulio, Greco, Pantaleo, Morano, Danila, Bianchi, Beatrice, Lombana Marino, Maria Giulia, Laraud, Federica, Ramone, Arianna, Cagnacci, Angelo, Barra, Fabio, Gustavino, Claudio, Ferrero, Simone, Ghezzi, Fabio, Cromi, Antonella, Laganà, Antonio Simone, Longo, Valentina Laurita, Stollagli, Francesca, Sirico, Angelo, Lanzone, Antonio, Driul, Lorenza, Cecchini D, Fabiana, Xodo, Serena, Rodriguez, Brian, Mercado-Olivares, Felipe, Elkafrawi, Deena, Sisti, Giovanni, Esposito, Rosanna, Coviello, Antonio, Cerbone, Marco, Morlando, Maddalena, Schiattarella, Antonio, Colacurci, Nicola, De Franciscis, Pasquale, Cataneo, Ilaria, Lenzi, Marinella, Sandri, Fabrizio, Buscemi, Riccardo, Gattei, Giorgia, Sala, Francesca Della, Valori, Eleonora, Rovellotti, Maria Cristina, Done, Elisa, Faron, Gille, Gucciardo, Leonardo, Esposito, Valentina, Vena, Flaminia, Giancotti, Antonella, Brunelli, Roberto, Muzii, Ludovico, Nappi, Luigi, Sorrentino, Felice, Vasciaveo, Lorenzo, Liberati, Marco, Buca, Danilo, Leombroni, Martina, Di Sebastiano, Francesca, Di Tizio, Luciano, Gazzolo, Diego, Franchi, Massimo, Ianniciello, Quintino Cesare, Garzon, Simone, Petriglia, Giuliano, Borrello, Leonardo, Nieto-Calvache, Albaro Josè, Burgos-Luna, Juan Manuel, Kadji, Caroline, Carlin, Andrew, Bevilacqua, Elisa, Moucho, Marina, Pinto, Pedro Viana, Figueiredo, Rita, Roselló, José Morale, Loscalzo, Gabriela, Martinez-Varea, Alicia, Diago, Vincente, Jimenez Lopez, Jesús S, Aykanat, Alicia Yeliz, Cosma, Stefano, Carosso, Andrea, Benedetto, Chiara, Bermejo, Amanda, May Feuerschuette, Otto Henrique, Uyaniklar, Ozlem, Ocakouglu, Sakine Rahimli, Atak, Zeliha, Haberal, Esra Tusta, Froessler, Bernd, Parange, Anupam, Palm, Peter, Samardjiski, Igor, Taccaliti, Chiara, Okuyan, Erhan, Daskalakis, George, Moreira de Sa, Renato Augusto, Pittaro, Alejandro, Gonzalez-Duran, Maria Luisa, Guisan, Ana Concheiro, Genç, Şerife Özlem, Zlatohlávková, Blanka, Piqueras, Anna Luengo, Oliva, Dolores Esteban, Cil, Aylin Pelin, Api, Olu, Antsaklis, Pano, Ples, Liana, Kyvernitakis, Ioanni, Maul, Holger, Malan, Marcel, Lila, Albert, Granese, Roberta, Ercoli, Alfredo, Zoccali, Giuseppe, Villasco, Andrea, Biglia, Nicoletta, Madalina, Ciuhodaru, Costa, Elena, Daelemans, Caroline, Pintiaux, Axelle, Yapar Eyi, Elif Gül, Cueto, Elisa, Hadar, Eran, Dollinger, Sarah, Brzezinski Sinai, Noa A, Huertas, Erasmo, Arango, Pedro, Sanchez, Amadeo, Schvartzman, Javier Alfonso, Cojocaru, Liviu, Turan, Sifa, Turan, Ozhan, Di Dedda, Maria Carmela, Molpeceres, Rebeca Garrote, Zdjelar, Snezana, Premru-Srsen, Tanja, Cerar, Lilijana Kornhauser, Druškovič, Mirjam, De Robertis, Valentina, Stefanovic, Vedran, Nupponen, Irmeli, Nelskylä, Kaisa, Khodjaeva, Zulfiya, Gorina, Ksenia A, Sukhikh, Gennady T, Maruotti, Giuseppe Maria, Visentin, Silvia, Cosmi, Erich, Ferrari, Jacopo, Gatti, Alessandra, Luvero, Daniela, Angioli, Roberto, Puri, Ludovica, Palumbo, Marco, D'Urso, Giusella, Colaleo, Francesco, Chiara Rapisarda, Agnese Maria, Carbone, Ilma Floriana, Mollo, Antonio, Nazzaro, Giovanni, Locci, Mariavittoria, Guida, Maurizio, Di Spiezio Sardo, Attilio, Panici, Pierluigi Benedetti, Berghella, Vincenzo, Flacco, Maria Elena, Manzoli, Lamberto, Bifulco, Giuseppe, Scambia, Giovanni, Zullo, Fulvio, and D'Antonio, Francesco
Subjects: COVID-19 Vaccine, Infectious Disease Transmission, Perinatal Death, Abortion, Clinical Laboratory Technique, Miscarriage, Cohort Studies, 0302 clinical medicine, COVID-19 Testing, Pregnancy, Risk Factors, 3123 Gynaecology and paediatrics, Secondary analysis, Perinatal medicine, Abortion, Spontaneou, Medicine, Vertical, 030212 general & internal medicine, Viral, Pregnancy Complications, Infectious, coronavirus, perinatal morbidity, perinatal mortality, covid-19, Coronavirus, Abortion, Spontaneous, COVID-19, COVID-19 Vaccines, Clinical Laboratory Techniques, Coronavirus Infections, Female, Gestational Age, Humans, Infant, Newborn, Infant, Premature, Infectious Disease Transmission, Vertical, Pandemics, Pneumonia, Viral, Pregnancy Outcome, Reverse Transcriptase Polymerase Chain Reaction, SARS-CoV-2, Betacoronavirus, Fetal Death, 030219 obstetrics & reproductive medicine, Obstetrics, Infectious, Gestational age, Obstetrics and Gynecology, 3. Good health, Settore MED/40, Gestation, Human, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Coronaviru, Socio-culturale, Intrauterine device, 03 medical and health sciences, PARVOVIRUS B19 INFECTION, Coronavirus, perinatal morbidity, perinatal mortality, Adverse effect, Premature, Fetus, Betacoronaviru, Pandemic, Coronavirus Infection, business.industry, Risk Factor, Spontaneous, MORTALITY, Infant, Odds ratio, Pneumonia, medicine.disease, Newborn, Pregnancy Complications, Pediatrics, Perinatology and Child Health, Pregnancy Complications, Infectiou, Cohort Studie, business
Abstract: Objectives To evaluate the strength of association between maternal and pregnancy characteristics and the risk of adverse perinatal outcomes in pregnancies with laboratory confirmed COVID-19. Methods Secondary analysis of a multinational, cohort study on all consecutive pregnant women with laboratory-confirmed COVID-19 from February 1, 2020 to April 30, 2020 from 73 centers from 22 different countries. A confirmed case of COVID-19 was defined as a positive result on real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay of nasal and pharyngeal swab specimens. The primary outcome was a composite adverse fetal outcome, defined as the presence of either abortion (pregnancy loss before 22 weeks of gestations), stillbirth (intrauterine fetal death after 22 weeks of gestation), neonatal death (death of a live-born infant within the first 28 days of life), and perinatal death (either stillbirth or neonatal death). Logistic regression analysis was performed to evaluate parameters independently associated with the primary outcome. Logistic regression was reported as odds ratio (OR) with 95% confidence interval (CI). Results Mean gestational age at diagnosis was 30.6±9.5 weeks, with 8.0% of women being diagnosed in the first, 22.2% in the second and 69.8% in the third trimester of pregnancy. There were six miscarriage (2.3%), six intrauterine device (IUD) (2.3) and 5 (2.0%) neonatal deaths, with an overall rate of perinatal death of 4.2% (11/265), thus resulting into 17 cases experiencing and 226 not experiencing composite adverse fetal outcome. Neither stillbirths nor neonatal deaths had congenital anomalies found at antenatal or postnatal evaluation. Furthermore, none of the cases experiencing IUD had signs of impending demise at arterial or venous Doppler. Neonatal deaths were all considered as prematurity-related adverse events. Of the 250 live-born neonates, one (0.4%) was found positive at RT-PCR pharyngeal swabs performed after delivery. The mother was tested positive during the third trimester of pregnancy. The newborn was asymptomatic and had negative RT-PCR test after 14 days of life. At logistic regression analysis, gestational age at diagnosis (OR: 0.85, 95% CI 0.8–0.9 per week increase; p Conclusions Early gestational age at infection, maternal ventilatory supports and low birthweight are the main determinants of adverse perinatal outcomes in fetuses with maternal COVID-19 infection. Conversely, the risk of vertical transmission seems negligible.
Published: 2021

45. Systematic review and meta-analysis of genetic association studies of pelvic organ prolapse

Author: Kristina, Allen-Brady, John W F, Chua, Romana, Cuffolo, Marianne, Koch, Felice, Sorrentino, and Rufus, Cartwright
Subjects: Polymorphism, Genetic, Humans, Genetic Association Studies, Pelvic Organ Prolapse, Genome-Wide Association Study
Abstract: Family and twin studies demonstrate that pelvic organ prolapse (POP) is heritable, but the genetic etiology is poorly understood. This review aimed to identify genetic loci and specific polymorphisms associated with POP, while assessing the strength, consistency, and risk of bias among reported associations.Updating an earlier systematic review, PubMed and HuGE Navigator as well as relevant conference abstracts were searched using genetic and phenotype keywords from 2015 to 2020. Screening and data extraction were performed in duplicate. Fixed and random effects meta-analyses were conducted using co-dominant models of inheritance. We assessed credibility of pooled associations using interim Venice criteria.We screened 504 new abstracts and included 46 published and 7 unpublished studies. In pooled analyses we found significant associations for four polymorphisms: rs2228480 at the ESR1 gene (OR 0.67 95% CI 0.46-0.98, IThe genetic contributions to POP remain poorly understood. Several biologically plausible variants have been identified, but much work is required to establish the role of these genes in the pathogenesis of POP or to establish a role for genetic testing in clinical practice.
Published: 2021

46. Search for anisotropic gravitational-wave backgrounds using data from Advanced LIGO and Advanced Virgo's first three observing runs

Author: A. Grimaldi, M. A. Barton, Samuele Cortese, Charlie Hoy, Charalampos Markakis, L. Trozzo, Albert Lazzarini, Benno Willke, A. Grado, P. Booker, C. Cahillane, Norichika Sago, J. Hennig, V. Gayathri, J. Baird, M. Jeunon, Sascha Husa, Samaya Nissanke, S. Walsh, A. Hreibi, M. J. Szczepańczyk, M. Chaturvedi, G. Venugopalan, S. R. Mohite, Alessandra Buonanno, Gabrielle Allen, H. Y. Cheung, Rana X. Adhikari, Om Sharan Salafia, F. Donovan, Edoardo Milotti, B. Lantz, M. A. Bizouard, B. K. Berger, Denis Martynov, Claudia Moreno, N. V. Krishnendu, Marco Bazzan, Satoshi Tsuchida, C. Ingram, D. A. Melchor, F. Marion, E. Goetz, Matthew Giesler, D.B. DeBra, Giuseppe Castaldi, S. G. Crowder, K. Ito, E. Lalande, M. Cannavacciuolo, E. N. Clark, Geoffrey Lovelace, L. Nguyen Quynh, J. D. E. Creighton, Lijing Shao, M. Carpinelli, J. Liu, A. Pasqualetti, R. Bajpai, F. Garufi, Archana Pai, Surendra Nadh Somala, Yoshiyuki Obuchi, C. Talbot, Carl-Johan Haster, S. Nozaki, H. Sun, V. JaberianHamedan, Tyson Littenberg, T. Washimi, T. D. Creighton, L. A. Rees, Silvia Corezzi, S. Bae, Kai-Feng Chen, F. Paoletti, Felice Sorrentino, C. L. Chan, P. Szewczyk, A. K. Prajapati, M. Patel, C. M. Mow-Lowry, Sergey P. Vyatchanin, L. Aiello, Luigi Troiano, M. Gosselin, R. Green, H. Yuzurihara, D. Hoyland, B. F. Whiting, J. Casanueva Diaz, V. M. Bedakihale, Masako Kakizaki, R. Maggiore, C. Van Den Broeck, E. Sowell, E. Coccia, M. E. Zucker, B. A. Weaver, G. Vajente, S. M. Gaebel, T. Shimoda, Y. Okutani, J. G. Rollins, A. Mhaske, H. Hansen, T. Wlodarczyk, Laura Cadonati, L. Rolland, S. T. Countryman, S. Penn, R. M. S. Schofield, K. Mogushi, H. Estelles, Y. Huang, P. A. Duverne, S. Karki, D. Moraru, A. Dmitriev, E. Floden, V. B. Adya, A. Renzini, G. L. Mansell, Y. K. Lecoeuche, G. M. Harry, L. Naticchioni, T. Shishido, Salvatore Vitale, A. Cumming, F. Di Renzo, Gianpietro Cagnoli, L.-W. Wei, S. Katsanevas, Madeline Wade, M. Tse, D. S. Tsai, D. M. Macleod, T. D. Ramirez, M. T. Hübner, Yasufumi Kojima, J. F. J. van den Brand, C. Pluchar, P. Chanial, Abhirup Ghosh, S. Sunil, M. Tacca, G. Kang, E. Capote, A. K. Mehta, N. Man, H. Pang, K. A. Strain, K. Haughian, P. Ruggi, A. Puecher, A. Mullavey, T. J. N. Nelson, Filip Morawski, P. J. Easter, G. Guixé, Xiaohui Fan, P. Leaci, Y. R. Chen, Alessandro Bertolini, J. C. Driggers, John A. Clark, Ben Farr, Fabrizio Barone, Giuseppe Intini, D. Rozza, V. Dattilo, Tejinder Kaur, Edwin J. Son, Isobel M. Romero-Shaw, T. C. Pechsiri, Umakant D. Rapol, G. S. Wallace, Stefan Hild, J. D. Jones, A. C. Baylor, L. M. DaneshgaranBajastani, R. Huxford, Surabhi Sachdev, Christopher J. Moore, V. V. Frolov, Kazuhiro Hayama, K. Venkateswara, R. Cotesta, R. Mittleman, Kentaro Komori, Soubhik Kumar Bhaumik, Yuri Levin, Akito Araya, J. Von Wrangel, T. Kajita, L. Kleybolte, S. Oshino, G. S. Davies, T. Huynh-Dinh, Hajime Sotani, A. Z. Jan, C. Makarem, Martin Hendry, Cecilio García-Quirós, Hong Wu, J.-G. Ducoin, Richard O'Shaughnessy, B. Barr, M. C. Díaz, A. Menendez-Vazquez, P. Figura, C. M. Compton, Antonios Kontos, B. L. Swinkels, Wei-Tou Ni, V. Tiwari, K. A. Thorne, Hisa-aki Shinkai, Isabel Cordero-Carrión, S. Wu, Ll. M. Mir, Junwei Cao, R. Kirchhoff, S. P. Jadhav, M. C. Heintze, Yann Bouffanais, V. Fafone, A. Pereira, J. A. Rocha, Nelson Christensen, S. A. Usman, E. G. Seo, E. K. Porter, Kendall Ackley, R. K. Nayak, A. Allocca, Marco Romanelli, Christophe Collette, C. J. Perez, B. D. O'Brien, R. P. Udall, R. C. Walet, C. Di Fronzo, T. R. Saravanan, J. Zhang, L. F. Ortega, V. P. Mitrofanov, R. Cummings, G. Koekoek, J. Betzwieser, M. Zhan, D. W. Yeeles, Antoine Heidmann, A. Brillet, G. Eddolls, A. D. Viets, D. Meacher, E. N. Tapia San Martin, K. Haris, F. Vetrano, Z. Hong, K. Kaihotsu, S. E. Dwyer, David Keitel, A. Hagiwara, L. C. Strang, R. L. Savage, Chunglee Kim, F. W. Yang, J. S. Kissel, H. Cao, Marc Favata, A. J. Weinstein, Fumihiro Uraguchi, Roger Jones, V. Villa-Ortega, David A. Williams, S. J. Cooper, N. Raza, I. W. Harry, C-Y. Lin, N. Y. Washington, N. Letendre, Nikhil Sarin, J. Heinzel, Thanh D. Nguyen, V. J. Roma, Leo Tsukada, E. Z. Hamilton, M. Matiushechkina, Nikita S. Shcheblanov, B. H. Hsieh, Y. Miyazaki, A. D. Huddart, N. Kawai, R. J. Trudeau, Anindita Ganguly, M. Diaz-Ortiz, J. Venneberg, W. Del Pozzo, P. F. Cohadon, K. E. Ramirez, H. Heitmann, D. Sawant, M. Laxen, Anchal Gupta, Kei Kotake, H. Y. Chia, E. Cuoco, N. A. Didio, E. N.Tapia San Mertin, Fabrizio Giulio Luca Pilo, F. E. Peña Arellano, A. Ueda, D. Lumaca, L. Xiao, A. P. Spencer, A. M. Farah, M. F. Carney, D. D. Brown, Chad Hanna, A. Bramley, Yue Zhao, C. Kimball, Sakae Araki, J. J. McCann, T. J. Slaven-Blair, S. ShyamSundar, C. Stachie, A. Parisi, J. Oberling, M. Pirello, Alena Ananyeva, A. Lartaux-Vollard, Suvadeep Bose, A. Depasse, A. F. Helmling-Cornell, Ajay Kumar, N. D. Ormsby, C. Whittle, Yuki Inoue, A. M. Gretarsson, C. Bradaschia, W-R. Xu, F. Carbognani, Yang Yang, Yoshiaki Himemoto, I. M. Pinto, I. La Rosa, Jean-René Cudell, C. De Rossi, Stanislav Babak, S. Sayah, H. Overmier, B. Garaventa, Nobutada Kimura, Ka Yee C. Lee, M. A. Okada, Matteo Pegoraro, Piero Rettegno, R. Gouaty, A. V. Bhandari, Z. Márka, M. Boer, Shubhanshu Tiwari, T. B. Edo, R. Gray, Masashi Ohkawa, V. Srivastava, Y. Aso, M. Fays, N. van Bakel, M. Leonardi, Osamu Miyakawa, Lior Cohen, R. Zhang, Ik Siong Heng, Geert Raaijmakers, P. Fulda, M. Mondin, K. Mason, S. Shibagaki, D. Rosińska, E. R. G. von Reis, Ray-Kuang Lee, F. Y. Khalili, Ofelia Durante, Jay D. Tasson, J. L. Willis, M. Eisenmann, Ofek Birnholtz, Sanjeev Dhurandhar, M. Merzougui, Sebastien Biscans, S. A. Nichols, A. Malik, S. Gaudio, G. Valdes, Pulak Ranjan Giri, A. Adams, I. Tosta e Melo, Deirdre Shoemaker, F. Robinet, J. K. Blackburn, Q. Chu, F. L. Linde, R. Tenorio, N. A. Holland, Yichen Huang, D. Sellers, G. R. Johns, S. Ponrathnam, Michael Williams, Moritz Mehmet, L. Terkowski, E. Cesarini, P. Kumar, A. Singha, Ken K. Y. Ng, M. Constancio, E. 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Bossilkov, A. Ramos-Buades, M. Bischi, Kiran Prasai, G. Ueshima, Kyujin Kwak, S. Nagano, V. Kringel, J. Bidler, R. Dean, A. B. Yelikar, D. Gao, E. Katsavounidis, K. Shimode, D. C. Y. Hui, F. Nocera, A. Grant, C. Zhao, D. Bankar, I. Dorrington, Xiuling Li, M. Branchesi, Xing-Jiang Zhu, Takuma Yamada, G. Vedovato, L. E. H. Datrier, Y. Sakai, I. Di Palma, J. Gais, L. K. Nuttall, R. Macas, G. Billingsley, D. Jariwala, K. Jung, R. Jaume, R. A. Eisenstein, Hee-Suk Cho, M. H. P. M. van Putten, Jishnu Suresh, L. Prudenzi, T. Zelenova, Riccardo Bassiri, D. B. Kozak, C. Vorvick, Ryan Magee, Nandita Khetan, R. Tso, M. Kovalam, Alec Mishkin, R. Cavalieri, Magnus Manske, A. K. Srivastava, A. E. Pace, K. Miyo, A. S. Hines, Roberto Chierici, P. Clearwater, S. Sudhagar, M. Pürrer, S. Kwang, I. Dave, S. Sato, D. Agarwal, Thierry Pradier, David Jones, A. Shoda, Marco Cavaglia, B. Hughey, N. Hirata, M. Curyło, Subroto Mukherjee, P. Astone, V. Kondrashov, Bruno Giacomazzo, L. Errico, D. B. Tanner, Kevin M. Ryan, Patrick M. Koch, Carmen S. Menoni, M. Korobko, T. Zhang, S. M. Aston, Michael W. Coughlin, Zhoujian Cao, I. Khan, S. Banagiri, T. Kawasaki, H. Radkins, J. Brooks, R. Musenich, M. Kamiizumi, J. Lange, Tania Regimbau, A. J. Tanasijczuk, A. M. Knee, K. Merfeld, Y. Tomigami, A. Viceré, Frances Hellman, K. Chakravarti, Arunava Mukherjee, Haruki Kitazawa, Fabio Marchesoni, J. Park, A. Chiummo, Kyungmin Kim, Debarati Chatterjee, B. O'Reilly, P. Gruning, Mario Spera, Peter Aufmuth, T. L. Lam, K. W. Tsang, E. J. Fauchon-Jones, Atsushi Nishizawa, Gianluca Grignani, D. Y. T. Pong, A. Gennai, A. Ain, E. Massera, Y. Asali, Y. Bae, D. Schaetzl, Thibaut Jacqmin, C. Olivetto, A. Yoon, M. Lormand, L. Zhang, D. Töyrä, O. Sauter, S. B. Anderson, K. M. Aleman, Graham Woan, Robert L. Byer, Stuart Reid, Riccardo Ciolfi, Yi Chen, Harald P. Pfeiffer, Peter T. H. Pang, Tomasz Bulik, T. Tomura, Francesco Chiadini, F. J. Hayes, A. Basti, C. I. Torrie, Alessandro Longo, Jürgen Heinze, K. Oohara, E. Maros, J. Glanzer, Manel Molina-Ruiz, Edward Seidel, Richard J. Oram, A. Bozzi, S. B. Coughlin, W. G. Anderson, G. Cella, Ryan N. Lang, D. D'Urso, Krzysztof Piotrzkowski, B. W. Schulte, Vuk Mandic, D. J. Stops, S. Ide, Y. Minenkov, M. Turconi, J. Junker, H. M. Lee, Jessica Steinlechner, M. Pracchia, A. Neunzert, Norikatsu Mio, D. Sentenac, M. Heurs, J. S. H. Lee, P. Couvares, Patrick Brady, T. Dal Canton, Felix Wellmann, J. Warner, Podila Satya Venkata Narasimha Sharma, E. K. Gustafson, M. Rizzo, G. Cho, Pablo Cerdá-Durán, Vivien Raymond, A. A. Ciobanu, David E. McClelland, J. C. Bayley, J.-P. Coulon, François Bondu, H. Chu, M. Kolstein, P. J. Veitch, M. Ball, M. L. Lollie, P. J. Sutton, M. Deenadayalan, Sung-Po Chao, R. De Simone, S. Ghosh, D. Passuello, F. Badaracco, E. A. Chase, Z. Frei, Jacob Scheuer, Astrid Lamberts, J. Woehler, S. V. Angelova, Kyohei Kawaguchi, I. Michaloliakos, R. Passaquieti, G. Pagano, Reed Essick, C. Nguyen, N. Kita, J. N. Hohmann, C. Jeon, A. Cirone, R. Coyne, Fabrice Matichard, R. De Rosa, Kazuyuki Tanaka, Bernard F. Schutz, Kwan-Lok Li, M. Ying, M. Saleem, Veronica Granata, Yi-Ting Hsu, M. Haney, A. Balsamo, S. Khadka, Marta Colleoni, Yuta Michimura, P. Thomas, M. Arène, J. A. Giaime, I. Nardecchia, A. Amato, L. E. Wade, B. U. Gadre, A. C. Green, J. Z. Wang, Y-K. Chu, K. Yokogawa, D. Corre, Y. M. Kim, R. G. Ormiston, Hyun Lee, J. Calderón Bustillo, Safura Sharifi, J. H. Romie, B. Edelman, G. Mendell, C. Rajan, S. Kandhasamy, M. Fishbach, R. Abbott, Samuel Deléglise, S. J. Jadhav, A. R. Williamson, A. Miyamoto, Felipe Guzman, I. Belahcene, Albert K. H. Kong, B. Sorazu, E. O'Shea, Y. Nakayama, Piotr Jaranowski, Kazuhiro Yamamoto, Geraint Pratten, H. Fair, H. W. Lee, Robert J. McCarthy, S. Takano, Linqing Wen, T. A. Callister, G. Kuehn, T. Sekiguchi, László Á. Gergely, A. Macquet, M. Boldrini, Philip F. Hopkins, Y. Kao, Fausto Acernese, K. Kuns, C-Y. Chiang, Laurent Pinard, Shaon Ghosh, F. J. Raab, N. Mukund, V. Savant, Valérie Martinez, M. Cieślar, Terry G. McRae, Takahiro Tanaka, J. B. Kanner, Li Ju, Yoshio Arai, Brittany Kamai, Andreu Sanuy, Y. Hiranuma, A. Fernandez-Galiana, Hideki Asada, C. V. Kalaghatgi, J. Hanson, H. Fong, G. Greco, Zong-Hong Zhu, Francesco Pannarale, A. L. Stuver, David Coward, A. Miani, Jan Harms, A. S. Sengupta, D. Bhattacharjee, Daniele A. Steer, H. Satari, D. Bersanetti, G. Ashton, B. Ikenoue, T. Yamamoto, E. Fenyvesi, C. Messenger, Fabrizio Bobba, Stephan Grimm, F. Hernandez Vivanco, C. H. Chan, E. Payne, Takashi Uchiyama, C. Gray, I. Fiori, A. K. Zadrożny, S. Ha, Kohei Yamamoto, T. J. Shaffer, Tomotada Akutsu, Shawn Rosofsky, H-S. Kuo, C. Osthelder, Daichi Tsuna, Anupreeta More, Y. Kuromiya, P. Relton, Michela Mapelli, Z. Chen, T. Mishra, R. Gustafson, G. A. Prodi, Andrea Chincarini, Minkyun Noh, Cesare Barbieri, Walter Winkler, A. S. Markosyan, R. DeSalvo, T. Z. Summerscales, A. Lemaître, J. N. Linley, F. Cipriano, Soichiro Morisaki, M. Bals, N. Radulesco, Kunihito Ioka, L. G. Prokhorov, Harald Lück, E. Knyazev, D. Verkindt, A. Rocchi, B. Goncharov, R. Birney, Zachariah B. Etienne, D. Lopez, Y. Drori, Jennifer Watchi, V. Boschi, M. van Beuzekom, H. L. Lin, A. L. James, Jade Powell, V. Mangano, C. Pankow, P. Dupej, M. Mantovani, Eric B. Flynn, J. Kume, Jianfang Wang, B. Gateley, A. Sur, T. Di Girolamo, Aaron Buikema, Hang Yu, N. Leroy, Kentaro Somiya, Iii H.W. Cain, D. Tsai, Christos Karathanasis, Eric Thrane, P. Barneo, W. Katzman, A. F. Vargas, T. Sadecki, Sheon Chua, R. Bonnand, Mariana Fazio, S. C. McGuire, J. F. Read, S. Di Pace, S. Otabe, Toshikazu Suzuki, Aldo Ejlli, M. Piendibene, M. K. M. Bader, D. L. Ferguson, Y. Sakuno, Miriam Lucio Martinez, Michael Thomas, S. Biscoveanu, W. Ogaki, E. Polini, B. Bécsy, Matthias H. Hennig, N. Van Remortel, Des Gibson, H. K. Gulati, Hiroyuki Nakano, Eric Grimes, P. M. Meyers, A. Branch, K. Sakai, J. V. van Heijningen, C. C. Wipf, M. Fyffe, S. Koley, M. Brinkmann, P. Prosposito, S. Grunewald, R. Prasanna, P. Popolizio, Koji Arai, Gabriela Gonzalez, K. R. Corley, S. Choudhary, J. N. Leviton, D. Pascucci, T. Uehara, R. Gamba, M. J. Cowart, M. Nery, S. Raja, S. Maliakal, Yuka Fujii, O. V. Palashov, Sean T. McWilliams, F. Piergiovanni, D. E. Cohen, C. Michel, Maria Luisa Chiofalo, A. E. Gleckl, Rajesh Kumar, Kuo-Chuan Pan, I. Maksimovic, A. Effler, A. Franke, Vivishek Sudhir, C. C. Kuo, R. L. Ward, G. Hemming, Valeria Sipala, David H. Reitze, H. Masalehdan, D. Buskulic, Rahul Kashyap, C. McIsaac, N. De Lillo, N. Sorrentino, W. Jia, H. Zhang, I. J. Hollows, D. H. Shoemaker, James Healy, Y. Moriwaki, Masaki Ando, H. Vahlbruch, Gunnar Riemenschneider, J. C. Mills, K. Riles, K. Kusayanagi, J. Y. Vinet, H. Middleton, C. Affeldt, Ettore Majorana, R. P. Fisher, S. Mitra, M. Zevin, M. Fukunaga, S. Frasca, Jonathan Richardson, Sarah Caudill, M. P. Thirugnanasambandam, E. J. Sanchez, D. Tuyenbayev, Maria Ilaria Del Principe, Yogesh Verma, Kai Staats, S. Mastrogiovanni, L. 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Cousins, Rory Smith, C. Adams, O. J. Piccinni, R. D. Rodriguez-Soto, Gor Oganesyan, C. Frederick, HyunGyu Suh, Doğa Veske, J. P. Zendri, A. F. Brooks, P. J. Quinonez, R. M. Blair, D. Sigg, C. García-Núñez, S. W. Ballmer, C. Kozakai, M. Takeda, E. M. Gretarsson, Ying Guo, D. Beniwal, J. McIver, Peter Fritschel, Wenxiao Wang, D. Davis, V. Valsan, E. Bonilla, Karsten Danzmann, T. Harder, Andrea H. Tapia, K. S. Phukon, Javier Sánchez, M. Masso-Reid, Michelle E. Walker, Z. J. Holmes, V. Del Favero, J. Eichholz, G. Moreno, H. Inchauspe, Y. Fujikawa, K. Isleif, Naoki Aritomi, E. Schwartz, A. W. Criswell, Lindsay DeMarchi, J. Petermann, Kenta Tanaka, A. Schindler-Tyka, Kimio Tsubono, J. Vanosky, Kazuhiro Agatsuma, M. Punturo, M. BenYaala, B. C. Pant, C. Messick, Matthew Evans, S. J. Rowlinson, D. Petterson, C. Magazzù, N. Arnaud, P. J. King, Jun'ichi Yokoyama, J. G. Guerrero, K. A. Pham, Frank Ohme, E. Leon, O. Halim, S. Klimenko, Ryutaro Takahashi, M. Tonelli, F. Muciaccia, M. J. Yap, K. 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Haegel, Viola Sordini, Masatake Ohashi, D. Mukherjee, B. Champion, P. Kolitsidou, B. Ratto, Nergis Mavalvala, Jerome Degallaix, M. Schneewind, C. Casentini, Naoko Ohishi, Sebastian Khan, B. C. Barish, F. De Matteis, Archisman Ghosh, Institut Lumière Matière [Villeurbanne] (ILM), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Astrophysique Relativiste Théories Expériences Métrologie Instrumentation Signaux (ARTEMIS), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut des Fonctions Optiques pour les Technologies de l'informatiON (Institut FOTON), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Nationale Supérieure des Sciences Appliquées et de Technologie (ENSSAT)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Kastler Brossel (LKB [Collège de France]), Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des matériaux avancés (LMA), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Joseph Louis LAGRANGE (LAGRANGE), Université Paris-Est Marne-la-Vallée (UPEM), Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL), Institut des Hautes Études Scientifiques (IHES), IHES, KAGRA, Virgo, LIGO Scientific, Spectroscopies optiques des matériaux verres, amorphes et à nanoparticules (SOPRANO), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-École Nationale Supérieure des Sciences Appliquées et de Technologie (ENSSAT)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut des Hautes Etudes Scientifiques (IHES), Abbott, R., Abbott, T. D., Abraham, S., Acernese, F., Ackley, K., Adams, A., Adams, C., Adhikari, R. X., Adya, V. B., Affeldt, C., Agarwal, D., Agathos, M., Agatsuma, K., Aggarwal, N., Aguiar, O. D., Aiello, L., Ain, A., Ajith, P., Akutsu, T., Aleman, K. M., Allen, G., Allocca, A., Altin, P. A., Amato, A., Anand, S., Ananyeva, A., Anderson, S. B., Anderson, W. G., Ando, M., Angelova, S. V., Ansoldi, S., Antelis, J. M., Antier, S., Appert, S., Arai, Koya, Arai, Koji, Arai, Y., Araki, S., Araya, A., Araya, M. C., Areeda, J. S., Arène, M., Aritomi, N., Arnaud, N., Aronson, S. M., Asada, H., Asali, Y., Ashton, G., Aso, Y., Aston, S. M., Astone, P., Aubin, F., Aufmuth, P., Aultoneal, K., Austin, C., Babak, S., Badaracco, F., Bader, M. K. M., Bae, S., Bae, Y., Baer, A. M., Bagnasco, S., Bai, Y., Baiotti, L., Baird, J., Bajpai, R., Ball, M., Ballardin, G., Ballmer, S. W., Bals, M., Balsamo, A., Baltus, G., Banagiri, S., Bankar, D., Bankar, R. S., Barayoga, J. C., Barbieri, C., Barish, B. C., Barker, D., Barneo, P., Barone, F., Barr, B., Barsotti, L., Barsuglia, M., Barta, D., Bartlett, J., Barton, M. A., Bartos, I., Bassiri, R., Basti, A., Bawaj, M., Bayley, J. C., Baylor, A. C., Bazzan, M., Bécsy, B., Bedakihale, V. M., Bejger, M., Belahcene, I., Benedetto, V., Beniwal, D., Benjamin, M. G., Bennett, T. F., Bentley, J. D., Benyaala, M., Bergamin, F., Berger, B. K., Bernuzzi, S., Bersanetti, D., Bertolini, A., Betzwieser, J., Bhandare, R., Bhandari, A. V., Bhattacharjee, D., Bhaumik, S., Bidler, J., Bilenko, I. A., Billingsley, G., Birney, R., Birnholtz, O., Biscans, S., Bischi, M., Biscoveanu, S., Bisht, A., Biswas, B., Bitossi, M., Bizouard, M. -A., Blackburn, J. K., Blackman, J., Blair, C. D., Blair, D. G., Blair, R. M., Bobba, F., Bode, N., Boer, M., Bogaert, G., Boldrini, M., Bondu, F., Bonilla, E., Bonnand, R., Booker, P., Boom, B. A., Bork, R., Boschi, V., Bose, N., Bose, S., Bossilkov, V., Boudart, V., Bouffanais, Y., Bozzi, A., Bradaschia, C., Brady, P. 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A., Chassande-Mottin, E., Chatterjee, D., Chaturvedi, M., Chen, A., Chen, C., Chen, H. Y., Chen, J., Chen, K., Chen, X., Chen, Y. -B., Chen, Y. -R., Chen, Z., Cheng, H., Cheong, C. K., Cheung, H. Y., Chia, H. Y., Chiadini, F., Chiang, C-Y., Chierici, R., Chincarini, A., Chiofalo, M. L., Chiummo, A., Cho, G., Cho, H. S., Choate, S., Choudhary, R. K., Choudhary, S., Christensen, N., Chu, H., Chu, Q., Chu, Y-K., Chua, S., Chung, K. W., Ciani, G., Ciecielag, P., Cieślar, M., Cifaldi, M., Ciobanu, A. A., Ciolfi, R., Cipriano, F., Cirone, A., Clara, F., Clark, E. N., Clark, J. A., Clarke, L., Clearwater, P., Clesse, S., Cleva, F., Coccia, E., Cohadon, P. -F., Cohen, D. E., Cohen, L., Colleoni, M., Collette, C. G., Colpi, M., Compton, C. M., Constancio, M., Conti, L., Cooper, S. J., Corban, P., Corbitt, T. R., Cordero-Carrión, I., Corezzi, S., Corley, K. R., Cornish, N., Corre, D., Corsi, A., Cortese, S., Costa, C. A., Cotesta, R., Coughlin, M. W., Coughlin, S. B., Coulon, J. -P., Countryman, S. T., Cousins, B., Couvares, P., Covas, P. B., Coward, D. M., Cowart, M. J., Coyne, D. C., Coyne, R., Creighton, J. D. E., Creighton, T. D., Criswell, A. W., Croquette, M., Crowder, S. G., Cudell, J. R., Cullen, T. J., Cumming, A., Cummings, R., Cuoco, E., Curyło, M., Canton, T. Dal, Dálya, G., Dana, A., Daneshgaranbajastani, L. M., D’Angelo, B., Danilishin, S. L., D’Antonio, S., Danzmann, K., Darsow-Fromm, C., Dasgupta, A., Datrier, L. E. H., Dattilo, V., Dave, I., Davier, M., Davies, G. S., Davis, D., Daw, E. J., Dean, R., Debra, D., Deenadayalan, M., Degallaix, J., De Laurentis, M., Deléglise, S., Del Favero, V., De Lillo, F., De Lillo, N., Del Pozzo, W., Demarchi, L. M., De Matteis, F., D’Emilio, V., Demos, N., Dent, T., Depasse, A., De Pietri, R., De Rosa, R., De Rossi, C., Desalvo, R., De Simone, R., Dhurandhar, S., Díaz, M. C., Diaz-Ortiz, M., Didio, N. A., Dietrich, T., Di Fiore, L., Di Fronzo, C., Di Giorgio, C., Di Giovanni, F., Di Girolamo, T., Di Lieto, A., Ding, B., Di Pace, S., Di Palma, I., Di Renzo, F., Divakarla, A. K., Dmitriev, A., Doctor, Z., D’Onofrio, L., Donovan, F., Dooley, K. L., Doravari, S., Dorrington, I., Drago, M., Driggers, J. C., Drori, Y., Du, Z., Ducoin, J. -G., Dupej, P., Durante, O., D’Urso, D., Duverne, P. -A., Dwyer, S. E., Easter, P. J., Ebersold, M., Eddolls, G., Edelman, B., Edo, T. B., Edy, O., Effler, A., Eguchi, S., Eichholz, J., Eikenberry, S. S., Eisenmann, M., Eisenstein, R. A., Ejlli, A., Enomoto, Y., Errico, L., Essick, R. C., Estellés, H., Estevez, D., Etienne, Z., Etzel, T., Evans, M., Evans, T. M., Ewing, B. E., Fafone, V., Fair, H., Fairhurst, S., Fan, X., Farah, A. M., Farinon, S., Farr, B., Farr, W. M., Farrow, N. W., Fauchon-Jones, E. J., Favata, M., Fays, M., Fazio, M., Feicht, J., Fejer, M. M., Feng, F., Fenyvesi, E., Ferguson, D. L., Fernandez-Galiana, A., Ferrante, I., Ferreira, T. A., Fidecaro, F., Figura, P., Fiori, I., Fishbach, M., Fisher, R. P., Fittipaldi, R., Fiumara, V., Flaminio, R., Floden, E., Flynn, E., Fong, H., Font, J. A., Fornal, B., Forsyth, P. W. F., Franke, A., Frasca, S., Frasconi, F., Frederick, C., Frei, Z., Freise, A., Frey, R., Fritschel, P., Frolov, V. V., Fronzé, G. G., Fujii, Y., Fujikawa, Y., Fukunaga, M., Fukushima, M., Fulda, P., Fyffe, M., Gabbard, H. A., Gadre, B. U., Gaebel, S. M., Gair, J. R., Gais, J., Galaudage, S., Gamba, R., Ganapathy, D., Ganguly, A., Gao, D., Gaonkar, S. G., Garaventa, B., García-Núñez, C., García-Quirós, C., Garufi, F., Gateley, B., Gaudio, S., Gayathri, V., Ge, G., Gemme, G., Gennai, A., George, J., Gergely, L., Gewecke, P., Ghonge, S., Ghosh, Abhirup., Ghosh, Archisman, Ghosh, Shaon, Ghosh, Shrobana, Ghosh, Sourath, Giacomazzo, B., Giacoppo, L., Giaime, J. A., Giardina, K. D., Gibson, D. R., Gier, C., Giesler, M., Giri, P., Gissi, F., Glanzer, J., Gleckl, A. E., Godwin, P., Goetz, E., Goetz, R., Gohlke, N., Goncharov, B., González, G., Gopakumar, A., Gosselin, M., Gouaty, R., Grace, B., Grado, A., Granata, M., Granata, V., Grant, A., Gras, S., Grassia, P., Gray, C., Gray, R., Greco, G., Green, A. C., Green, R., Gretarsson, A. M., Gretarsson, E. M., Griffith, D., Griffiths, W., Griggs, H. L., Grignani, G., Grimaldi, A., Grimes, E., Grimm, S. J., Grote, H., Grunewald, S., Gruning, P., Guerrero, J. G., Guidi, G. M., Guimaraes, A. R., Guixé, G., Gulati, H. K., Guo, H. -K., Guo, Y., Gupta, Anchal, Gupta, Anuradha, Gupta, P., Gustafson, E. K., Gustafson, R., Guzman, F., Ha, S., Haegel, L., Hagiwara, A., Haino, S., Halim, O., Hall, E. D., Hamilton, E. Z., Hammond, G., Han, W. -B., Haney, M., Hanks, J., Hanna, C., Hannam, M. D., Hannuksela, O. A., Hansen, H., Hansen, T. J., Hanson, J., Harder, T., Hardwick, T., Haris, K., Harms, J., Harry, G. M., Harry, I. W., Hartwig, D., Hasegawa, K., Haskell, B., Hasskew, R. K., Haster, C. -J., Hattori, K., Haughian, K., Hayakawa, H., Hayama, K., Hayes, F. J., Healy, J., Heidmann, A., Heintze, M. C., Heinze, J., Heinzel, J., Heitmann, H., Hellman, F., Hello, P., Helmling-Cornell, A. F., Hemming, G., Hendry, M., Heng, I. S., Hennes, E., Hennig, J., Hennig, M. H., Vivanco, F. Hernandez, Heurs, M., Hild, S., Hill, P., Himemoto, Y., Hines, A. S., Hiranuma, Y., Hirata, N., Hirose, E., Hochheim, S., Hofman, D., Hohmann, J. N., Holgado, A. M., Holland, N. A., Hollows, I. J., Holmes, Z. J., Holt, K., Holz, D. E., Hong, Z., Hopkins, P., Hough, J., Howell, E. J., Hoy, C. G., Hoyland, D., Hreibi, A., Hsieh, B-H., Hsu, Y., Huang, G-Z., Huang, H-Y., Huang, P., Huang, Y-C., Huang, Y. -J., Huang, Y. -W., Hübner, M. T., Huddart, A. D., Huerta, E. A., Hughey, B., Hui, D. C. Y., Hui, V., Husa, S., Huttner, S. H., Huxford, R., Huynh-Dinh, T., Ide, S., Idzkowski, B., Iess, A., Ikenoue, B., Imam, S., Inayoshi, K., Inchauspe, H., Ingram, C., Inoue, Y., Intini, G., Ioka, K., Isi, M., Isleif, K., Ito, K., Itoh, Y., Iyer, B. R., Izumi, K., Jaberianhamedan, V., Jacqmin, T., Jadhav, S. J., Jadhav, S. P., James, A. L., Jan, A. Z., Jani, K., Janssens, K., Janthalur, N. N., Jaranowski, P., Jariwala, D., Jaume, R., Jenkins, A. C., Jeon, C., Jeunon, M., Jia, W., Jiang, J., Jin, H. -B., Johns, G. R., Jones, A. W., Jones, D. I., Jones, J. D., Jones, P., Jones, R., Jonker, R. J. G., Ju, L., Jung, K., Jung, P., Junker, J., Kaihotsu, K., Kajita, T., Kakizaki, M., Kalaghatgi, C. V., Kalogera, V., Kamai, B., Kamiizumi, M., Kanda, N., Kandhasamy, S., Kang, G., Kanner, J. B., Kao, Y., Kapadia, S. J., Kapasi, D. P., Karat, S., Karathanasis, C., Karki, S., Kashyap, R., Kasprzack, M., Kastaun, W., Katsanevas, S., Katsavounidis, E., Katzman, W., Kaur, T., Kawabe, K., Kawaguchi, K., Kawai, N., Kawasaki, T., Kéfélian, F., Keitel, D., Key, J. S., Khadka, S., Khalili, F. Y., Khan, I., Khan, S., Khazanov, E. A., Khetan, N., Khursheed, M., Kijbunchoo, N., Kim, C., Kim, J. C., Kim, J., Kim, K., Kim, W. S., Kim, Y. -M., Kimball, C., Kimura, N., King, P. J., Kinley-Hanlon, M., Kirchhoff, R., Kissel, J. S., Kita, N., Kitazawa, H., Kleybolte, L., Klimenko, S., Knee, A. M., Knowles, T. D., Knyazev, E., Koch, P., Koekoek, G., Kojima, Y., Kokeyama, K., Koley, S., Kolitsidou, P., Kolstein, M., Komori, K., Kondrashov, V., Kong, A. K. H., Kontos, A., Koper, N., Korobko, M., Kotake, K., Kovalam, M., Kozak, D. B., Kozakai, C., Kozu, R., Kringel, V., Krishnendu, N. V., Królak, A., Kuehn, G., Kuei, F., Kumar, A., Kumar, P., Kumar, Rahul, Kumar, Rakesh, Kume, J., Kuns, K., Kuo, C., Kuo, H-S., Kuromiya, Y., Kuroyanagi, S., Kusayanagi, K., Kwak, K., Kwang, S., Laghi, D., Lalande, E., Lam, T. L., Lamberts, A., Landry, M., Lane, B. B., Lang, R. N., Lange, J., Lantz, B., La Rosa, I., Lartaux-Vollard, A., Lasky, P. D., Laxen, M., Lazzarini, A., Lazzaro, C., Leaci, P., Leavey, S., Lecoeuche, Y. K., Lee, H. K., Lee, H. M., Lee, H. W., Lee, J., Lee, K., Lee, R., Lehmann, J., Lemaître, A., Leon, E., Leonardi, M., Leroy, N., Letendre, N., Levin, Y., Leviton, J. N., Li, A. K. Y., Li, B., Li, J., Li, K. L., Li, T. G. F., Li, X., Lin, C-Y., Lin, F-K., Lin, F-L., Lin, H. L., Lin, L. C. -C., Linde, F., Linker, S. D., Linley, J. N., Littenberg, T. B., Liu, G. C., Liu, J., Liu, K., Liu, X., Llorens-Monteagudo, M., Lo, R. K. L., Lockwood, A., Lollie, M. L., London, L. T., Longo, A., Lopez, D., Lorenzini, M., Loriette, V., Lormand, M., Losurdo, G., Lough, J. D., Lousto, C. O., Lovelace, G., Lück, H., Lumaca, D., Lundgren, A. P., Luo, L. -W., Macas, R., Macinnis, M., Macleod, D. M., Macmillan, I. A. O., Macquet, A., Hernandez, I. Magaña, Magaña-Sandoval, F., Magazzù, C., Magee, R. M., Maggiore, R., Majorana, E., Makarem, C., Maksimovic, I., Maliakal, S., Malik, A., Man, N., Mandic, V., Mangano, V., Mango, J. L., Mansell, G. L., Manske, M., Mantovani, M., Mapelli, M., Marchesoni, F., Marchio, M., Marion, F., Mark, Z., Márka, S., Márka, Z., Markakis, C., Markosyan, A. S., Markowitz, A., Maros, E., Marquina, A., Marsat, S., Martelli, F., Martin, I. W., Martin, R. M., Martinez, M., Martinez, V., Martinovic, K., Martynov, D. V., Marx, E. J., Masalehdan, H., Mason, K., Massera, E., Masserot, A., Massinger, T. J., Masso-Reid, M., Mastrogiovanni, S., Matas, A., Mateu-Lucena, M., Matichard, F., Matiushechkina, M., Mavalvala, N., Mccann, J. J., Mccarthy, R., Mcclelland, D. E., Mcclincy, P., Mccormick, S., Mcculler, L., Mcghee, G. I., Mcguire, S. C., Mcisaac, C., Mciver, J., Mcmanus, D. J., Mcrae, T., Mcwilliams, S. T., Meacher, D., Mehmet, M., Mehta, A. K., Melatos, A., Melchor, D. A., Mendell, G., Menendez-Vazquez, A., Menoni, C. S., Mercer, R. A., Mereni, L., Merfeld, K., Merilh, E. L., Merritt, J. D., Merzougui, M., Meshkov, S., Messenger, C., Messick, C., Meyers, P. M., Meylahn, F., Mhaske, A., Miani, A., Miao, H., Michaloliakos, I., Michel, C., Michimura, Y., Middleton, H., Milano, L., Miller, A. L., Millhouse, M., Mills, J. C., Milotti, E., Milovich-Goff, M. C., Minazzoli, O., Minenkov, Y., Mio, N., Mir, Ll. M., Mishkin, A., Mishra, C., Mishra, T., Mistry, T., Mitra, S., Mitrofanov, V. P., Mitselmakher, G., Mittleman, R., Miyakawa, O., Miyamoto, A., Miyazaki, Y., Miyo, K., Miyoki, S., Mo, Geoffrey, Mogushi, K., Mohapatra, S. R. P., Mohite, S. R., Molina, I., Molina-Ruiz, M., Mondin, M., Montani, M., Moore, C. J., Moraru, D., Morawski, F., More, A., Moreno, C., Moreno, G., Mori, Y., Morisaki, S., Moriwaki, Y., Mours, B., Mow-Lowry, C. M., Mozzon, S., Muciaccia, F., Mukherjee, Arunava, Mukherjee, D., Mukherjee, Soma, Mukherjee, Subroto, Mukund, N., Mullavey, A., Munch, J., Muñiz, E. A., Murray, P. G., Musenich, R., Nadji, S. L., Nagano, K., Nagano, S., Nakamura, K., Nakano, H., Nakano, M., Nakashima, R., Nakayama, Y., Nardecchia, I., Narikawa, T., Naticchioni, L., Nayak, B., Nayak, R. K., Negishi, R., Neil, B. F., Neilson, J., Nelemans, G., Nelson, T. J. N., Nery, M., Neunzert, A., Ng, K. Y., Ng, S. W. S., Nguyen, C., Nguyen, P., Nguyen, T., Quynh, L. Nguyen, Ni, W. -T., Nichols, S. A., Nishizawa, A., Nissanke, S., Nocera, F., Noh, M., Norman, M., North, C., Nozaki, S., Nuttall, L. K., Oberling, J., O’Brien, B. D., Obuchi, Y., O’Dell, J., Ogaki, W., Oganesyan, G., Oh, J. J., Oh, K., Oh, S. H., Ohashi, M., Ohishi, N., Ohkawa, M., Ohme, F., Ohta, H., Okada, M. 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Subjects: gravitational radiation: anisotropy, Physics and Astronomy (miscellaneous), gravitational radiation: stochastic, Astronomy, Astrophysics, 01 natural sciences, General Relativity and Quantum Cosmology, Physics, Particles & Fields, Cosmology & Astrophysics, energy: flux, energy: density, gravitational radiation: energy, LIGO, QC, QB, Physics, Settore FIS/01, Spectral index, Galactic Center, Amplitude, General relativity, Sidereal time, Physical Sciences, [PHYS.GRQC]Physics [physics]/General Relativity and Quantum Cosmology [gr-qc], gravitational radiation: power spectrum, Gravitation, data analysis method, Anisotropic stochastic gravitational-wave background, Experimental studies of gravity, FOS: Physical sciences, O3, O2, General Relativity and Quantum Cosmology (gr-qc), Astronomy & Astrophysics, Stochastic Background, Gravitational Waves, LIGO, Virgo, O1, O2, O3, O1, Gravitational waves, UPPER LIMITS, statistical analysis, 0103 physical sciences, advanced LIGO and Virgo, ddc:530, KAGRA, 010306 general physics, STFC, gravitational waves, Virgo, Gravitational Waves, Science & Technology, 010308 nuclear & particles physics, Gravitational wave, gravitational radiation: background, RCUK, Galaxy, VIRGO, gravitational radiation: emission, spectrum: density, RADIATION, CROSS-CORRELATION SEARCH, Stochastic Background, Dewey Decimal Classification::500 | Naturwissenschaften::530 | Physik, galaxy
Abstract: We report results from searches for anisotropic stochastic gravitational-wave backgrounds using data from the first three observing runs of the Advanced LIGO and Advanced Virgo detectors. For the first time, we include Virgo data in our analysis and run our search with a new efficient pipeline called {\tt PyStoch} on data folded over one sidereal day. We use gravitational-wave radiometry (broadband and narrow band) to produce sky maps of stochastic gravitational-wave backgrounds and to search for gravitational waves from point sources. A spherical harmonic decomposition method is employed to look for gravitational-wave emission from spatially-extended sources. Neither technique found evidence of gravitational-wave signals. Hence we derive 95\% confidence-level upper limit sky maps on the gravitational-wave energy flux from broadband point sources, ranging from $F_{\alpha, \Theta} < {\rm (0.013 - 7.6)} \times 10^{-8} {\rm erg \, cm^{-2} \, s^{-1} \, Hz^{-1}},$ and on the (normalized) gravitational-wave energy density spectrum from extended sources, ranging from $\Omega_{\alpha, \Theta} < {\rm (0.57 - 9.3)} \times 10^{-9} \, {\rm sr^{-1}}$, depending on direction ($\Theta$) and spectral index ($\alpha$). These limits improve upon previous limits by factors of $2.9 - 3.5$. We also set 95\% confidence level upper limits on the frequency-dependent strain amplitudes of quasimonochromatic gravitational waves coming from three interesting targets, Scorpius X-1, SN 1987A and the Galactic Center, with best upper limits range from $h_0 < {\rm (1.7-2.1)} \times 10^{-25},$ a factor of $\geq 2.0$ improvement compared to previous stochastic radiometer searches., Comment: 23 Pages, 9 Figures
Published: 2021
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47. The singular case of multiple chorangioma syndrome in an IVF pregnancy. Analysis of the case and review of literature

Author: Felice Sorrentino, Stefania Carlucci, Bianca Masturzo, Guido Menato, Giovanni Botta, Luigi Nappi, and Guglielmo Stabile
Subjects: 0301 basic medicine, Placenta Diseases, Perinatal Death, Disease, Chorangiomatosis, Hydrops, IVF pregnancy, Multiple chorangiomas, Villous capillary lesions, Anemia, Neonatal, Cardiovascular Diseases, Fatal Outcome, Female, Hemangioma, Humans, Hypoxia, Infant, Newborn, Middle Aged, Neoplasms, Multiple Primary, Pregnancy, Syndrome, Uterine Neoplasms, Fertilization in Vitro, 0302 clinical medicine, Multiple Primary, Neonatal, Neoplasms, Medicine, 030219 obstetrics & reproductive medicine, Obstetrics, Incidence (epidemiology), Obstetrics and Gynecology, Anemia, medicine.symptom, medicine.medical_specialty, Lesion, 03 medical and health sciences, Advanced maternal age, Fetus, business.industry, Chorangiosis, Infant, Chorangioma, medicine.disease, Newborn, 030104 developmental biology, Reproductive Medicine, business, Developmental Biology
Abstract: The redacted classification of placental lesions identifies in the group of fetal-stromal vascular lesions a subgroup called villous capillary lesions. The causes of villous capillary lesions appear to involve excessive angiogenesis. These conditions include chorangiosis, chorangiomatosis, chorangioma and a rare variant of the latter called multiple chorangioma syndrome where multiple chorangiomas, ranging from very small early precursor lesions to typical macroscopic chorangioma, occupy up to 80% of the total placental parenchyma. We present the first case of multiple chorangioma syndrome in an oncologic patient who obtained the pregnancy by egg donation, comparing the clinical case with ones available in literature. Fifteen cases have been previously published in literature but only 11 were eligible for the present review. We compared clinical characteristics and fetal outcomes with our clinical case, to highlight similarities and differences useful for a better understanding of this rare and partially unknown disease. Multiple chorangioma syndrome is a rare villous capillary lesion associated with poor fetal condition. All cases analyzed have been conceived naturally and our case is the first described in an IVF pregnancy. We believe that in our case the advanced maternal age, the method of conception and the previous chemo-therapeutic treatments might have played an important role in determining the manifestation of this rare placental condition. However, there is not appropriate literature supporting our consideration and, for future studies, it could be reasonable investigate the incidence of this condition, or even the incidence of all cluster of villous capillary lesions, in oncologic and IVF patients.
Published: 2021

48. Maternal and perinatal outcomes of pregnant women with SARS-CoV-2 infection

Author: Di Mascio Daniele, Gabriele, Saccone, Cihat, Sen, Daniele Di Mascio, Alberto, Galindo, Amos, Grünebaum, Jun, Yoshimatsu, Milan, Stanojevic, Asım, Kurjak, Frank, Chervenak, María José Rodríguez Suárez, Zita Maria Gambacorti-Passerini, María de Los Angeles Anaya Baz, Esther Vanessa Aguilar Galán, Yolanda Cuñarro López, Juan Antonio De León Luis, Ignacio Cueto Hernández, Ignacio, Herraiz, Cecilia, Villalain, Roberta, Venturella, Rizzo, GIUSEPPE DAVIDE, Ilenia, Mappa, Giovanni, Gerosolima, Lars, Hellmeyer, Josefine, Königbauer, Giada, Ameli, Tiziana, Frusca, Nicola, Volpe, Giovanni Battista Luca Schera, Stefania, Fieni, Eutalia, Esposito, Giuliana, Simonazzi, Gaetana Di Donna, Aly, Youssef, Anna Nunzia Della Gatta, Mariano Catello Di Donna, Vito, Chiantera, Natalina, Buono, Giulio, Sozzi, Pantaleo, Greco, Danila, Morano, Beatrice, Bianchi, Maria Giulia Lombana Marino, Federica, Laraud, Arianna, Ramone, Angelo, Cagnacci, Fabio, Barra, Claudio, Gustavino, Ferrero, Simone, Fabio, Ghezzi, Antonella, Cromi, Antonio Simone Laganà, Valentina Laurita Longo, Francesca, Stollagli, Angelo, Sirico, Antonio, Lanzone, Lorenza, Driul, Fabiana, Cecchini, Serena, Xodo, Brian, Rodriguez, Felipe, Mercado-Olivares, Deena, Elkafrawi, Giovanni, Sisti, Rosanna, Esposito, Antonio, Coviello, Marco, Cerbone, Maddalena, Morlando, Antonio, Schiattarella, Nicola, Colacurci, Pasquale De Franciscis, Ilaria, Cataneo, Marinella, Lenzi, Fabrizio, Sandri, Riccardo, Buscemi, Giorgia, Gattei, Francesca Della Sala, Eleonora, Valori, Maria Cristina Rovellotti, Elisa, Done, Gilles, Faron, Leonardo, Gucciardo, Esposito, Valentina, Flaminia, Vena, Antonella, Giancotti, Roberto, Brunelli, Ludovico, Muzii, Luigi, Nappi, Felice, Sorrentino, Marco, Liberati, Danilo, Buca, Martina, Leombroni, Francesca Di Sebastiano, Massimo, Franchi, Quintino Cesare Ianniciello, Simone, Garzon, Giuliano, Petriglia, Leonardo, Borrello, Albaro Josè Nieto-Calvache, Juan Manuel Burgos-Luna, Caroline, Kadji, Andrew, Carlin, Elisa, Bevilacqua, Marina, Moucho, Pedro, Viana, Rita, Figueiredo, José Morales Roselló, Gabriela, Loscalzo, Alicia, Martinez-Varea, Vincente, Diago, Jesús, S Jimenez Lopez, Alicia Yeliz Aykanat, Cosma, Stefano Domenico, Carosso, ANDREA ROBERTO, Benedetto, Chiara, Amanda, Bermejo, Otto Henrique May Feuerschuette, Ozlem, Uyaniklar, Sakine Rahimli Ocakouglu, Zeliha, Atak, Reyhan, Gündüz, Esra Tustas Haberal, Bernd, Froessler, Anupam, Parange, Peter, Palm, Igor, Samardjiski, Chiara, Taccaliti, Erhan, Okuyan, George, Daskalakis, Renato Augusto Moreira de Sa, Alejandro, Pittaro, Maria Luisa Gonzalez-Duran, Ana Concheiro Guisan, Şerife Özlem Genç, Blanka, Zlatohlávková, Anna Luengo Piqueras, Dolores Esteban Oliva, Aylin Pelin Cil, Olus, Api, Panos, Antsaklis, Liana, Ples, Ioannis, Kyvernitakis, Holger, Maul, Marcel, Malan, Albert, Lila, Roberta, Granese, Alfredo, Ercoli, Giuseppe, Zoccali, Villasco, Andrea, Biglia, Nicoletta, Ciuhodaru, Madalina, Costa, Elena, Caroline, Daelemans, Axelle, Pintiaux, Elif Gül Yapar Eyi, Elisa, Cueto, Eran, Hadar, Sarah, Dollinger, Noa, A Brzezinski-Sinai, Erasmo, Huertas, Pedro, Arango, Amadeo, Sanchez, Javier Alfonso Schvartzman, Liviu, Cojocaru, Sifa, Turan, Ozhan, Turan, Maria Carmela Di Dedda, Rebeca Garrote Molpeceres, Snezana, Zdjelar, Tanja, Premru-Srsen, Lilijana, Kornhauser-Cerar, Mirjam, Druškovič, Valentina De Robertis, Vedran, Stefanovic, Irmeli, Nupponen, Kaisa, Nelskylä, Zulfiya, Khodjaeva, Ksenia, A Gorina, Gennady, T Sukhikh, Giuseppe Maria Maruotti, Silvia, Visentin, Erich, Cosmi, Jacopo, Ferrari, Alessandra, Gatti, Daniela, Luvero, Roberto, Angioli, Ludovica, Puri, Marco, Palumbo, Giusella, D'Urso, Francesco, Colaleo, Agnese Maria Chiara Rapisarda, Ilma Floriana Carbone, Manzoli, Lamberto, Maria Elena Flacco, Giovanni, Nazzaro, Mariavittoria, Locci, Maurizio, Guida, Attilio Di Spiezio Sardo, Pierluigi Benedetti Panici, Asma, Khalil, Vincenzo, Berghella, Giuseppe, Bifulco, Giovanni, Scambia, Fulvio, Zullo, Francesco, D'Antonio, Saccone, Gabriele, Sen, Cihat, Di Mascio, Daniele, Galindo, Alberto, Grünebaum, Amo, Yoshimatsu, Jun, Stanojevic, Milan, Kurjak, Asım, Chervenak, Frank, Suárez, María José Rodríguez, Gambacorti‐Passerini, Zita Maria, de los Angeles Anaya Baz, María, Galán, Esther Vanessa Aguilar, López, Yolanda Cuñarro, Luis, Juan Antonio De León, Hernández, Ignacio Cueto, Herraiz, Ignacio, Villalain, Cecilia, Venturella, Roberta, Rizzo, Giuseppe, Mappa, Ilenia, Gerosolima, Giovanni, Hellmeyer, Lar, Königbauer, Josefine, Ameli, Giada, Frusca, Tiziana, Volpe, Nicola, Schera, Giovanni Battista Luca, Fieni, Stefania, Esposito, Eutalia, Simonazzi, Giuliana, Di Donna, Gaetana, Youssef, Aly, Gatta, Anna Nunzia Della, Di Donna, Mariano Catello, Chiantera, Vito, Buono, Natalina, Sozzi, Giulio, Greco, Pantaleo, Morano, Danila, Bianchi, Beatrice, Marino, Maria Giulia Lombana, Laraud, Federica, Ramone, Arianna, Cagnacci, Angelo, Barra, Fabio, Gustavino, Claudio, Ferrero, Simone, Ghezzi, Fabio, Cromi, Antonella, Laganà, Antonio Simone, Longo, Valentina Laurita, Stollagli, Francesca, Sirico, Angelo, Lanzone, Antonio, Driul, Lorenza, Cecchini, Fabiana, Xodo, Serena, Rodriguez, Brian, Mercado‐Olivares, Felipe, Elkafrawi, Deena, Sisti, Giovanni, Esposito, Rosanna, Coviello, Antonio, Cerbone, Marco, Morlando, Maddalena, Schiattarella, Antonio, Colacurci, Nicola, De Franciscis, Pasquale, Cataneo, Ilaria, Lenzi, Marinella, Sandri, Fabrizio, Buscemi, Riccardo, Gattei, Giorgia, Sala, Francesca Della, Valori, Eleonora, Rovellotti, Maria Cristina, Done, Elisa, Faron, Gille, Gucciardo, Leonardo, Esposito, Valentina, Vena, Flaminia, Giancotti, Antonella, Brunelli, Roberto, Muzii, Ludovico, Nappi, Luigi, Sorrentino, Felice, Liberati, Marco, Buca, Danilo, Leombroni, Martina, Di Sebastiano, Francesca, Franchi, Massimo, Ianniciello, Quintino Cesare, Garzon, Simone, Petriglia, Giuliano, Borrello, Leonardo, Nieto‐Calvache, Albaro Josè, Burgos‐Luna, Juan Manuel, Kadji, Caroline, Carlin, Andrew, Bevilacqua, Elisa, Moucho, Marina, Viana Pinto, Pedro, Figueiredo, Rita, Morales Roselló, José, Loscalzo, Gabriela, Martinez‐Varea, Alicia, Diago, Vincente, Jimenez Lopez, Jesús S, Aykanat, Alicia Yeliz, Cosma, Stefano, Carosso, Andrea, Benedetto, Chiara, Bermejo, Amanda, Feuerschuette, Otto Henrique May, Uyaniklar, Ozlem, Ocakouglu, Sakine Rahimli, Atak, Zeliha, Gündüz, Reyhan, Haberal, Esra Tusta, Froessler, Bernd, Parange, Anupam, Palm, Peter, Samardjiski, Igor, Taccaliti, Chiara, Okuyan, Erhan, Daskalakis, George, de Sa, Renato Augusto Moreira, Pittaro, Alejandro, Gonzalez‐Duran, Maria Luisa, Guisan, Ana Concheiro, Genç, Şerife Özlem, Zlatohlávková, Blanka, Piqueras, Anna Luengo, Oliva, Dolores Esteban, Cil, Aylin Pelin, Api, Olu, Antsaklis, Pano, Ples, Liana, Kyvernitakis, Ioanni, Maul, Holger, Malan, Marcel, Lila, Albert, Granese, Roberta, Ercoli, Alfredo, Zoccali, Giuseppe, Villasco, Andrea, Biglia, Nicoletta, Madalina, Ciuhodaru, Costa, Elena, Daelemans, Caroline, Pintiaux, Axelle, Eyi, Elif Gül Yapar, Cueto, Elisa, Hadar, Eran, Dollinger, Sarah, Brzezinski‐Sinai, Noa A., Huertas, Erasmo, Arango, Pedro, Sanchez, Amadeo, Schvartzman, Javier Alfonso, Cojocaru, Liviu, Turan, Sifa, Turan, Ozhan, Di Dedda, Maria Carmela, Molpeceres, Rebeca Garrote, Zdjelar, Snezana, Premru‐Srsen, Tanja, Kornhauser‐Cerar, Lilijana, Druškovič, Mirjam, De Robertis, Valentina, Stefanovic, Vedran, Nupponen, Irmeli, Nelskylä, Kaisa, Khodjaeva, Zulfiya, Gorina, Ksenia A., Sukhikh, Gennady T., Maruotti, Giuseppe Maria, Visentin, Silvia, Cosmi, Erich, Ferrari, Jacopo, Gatti, Alessandra, Luvero, Daniela, Angioli, Roberto, Puri, Ludovica, Palumbo, Marco, D'Urso, Giusella, Colaleo, Francesco, Rapisarda, Agnese Maria Chiara, Carbone, Ilma Floriana, Manzoli, Lamberto, Flacco, Maria Elena, Nazzaro, Giovanni, Locci, Mariavittoria, Guida, Maurizio, Sardo, Attilio Di Spiezio, Panici, Pierluigi Benedetti, Khalil, Asma, Berghella, Vincenzo, Bifulco, Giuseppe, Scambia, Giovanni, Zullo, Fulvio, D'Antonio, Francesco, Dicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve DoğumAna Bilim Dalı, University of Helsinki, Department of Obstetrics and Gynecology, HUS Gynecology and Obstetrics, HUS Children and Adolescents, Children's Hospital, HUS Perioperative, Intensive Care and Pain Medicine, Anestesiologian yksikkö, Department of Diagnostics and Therapeutics, Saccone, G., Sen, C., Di Mascio, D., Galindo, A., Grunebaum, A., Yoshimatsu, J., Stanojevic, M., Kurjak, A., Chervenak, F., Suarez, M. J. R., Gambacorti-Passerini, Z. M., de los Angeles Anaya Baz, M., Galan, E. V. A., Lopez, Y. C., Luis, J. A. D. L., Hernandez, I. C., Herraiz, I., Villalain, C., Venturella, R., Rizzo, G., Mappa, I., Gerosolima, G., Hellmeyer, L., Konigbauer, J., Ameli, G., Frusca, T., Volpe, N., Schera, G. B. L., Fieni, S., Esposito, E., Simonazzi, G., Di Donna, G., Youssef, A., Gatta, A. N. D., Di Donna, M. C., Chiantera, V., Buono, N., Sozzi, G., Greco, P., Morano, D., Bianchi, B., Marino, M. G. L., Laraud, F., Ramone, A., Cagnacci, A., Barra, F., Gustavino, C., Ferrero, S., Ghezzi, F., Cromi, A., Lagana, A. S., Longo, V. L., Stollagli, F., Sirico, A., Lanzone, A., Driul, L., Cecchini, F., Xodo, S., Rodriguez, B., Mercado-Olivares, F., Elkafrawi, D., Sisti, G., Esposito, R., Coviello, A., Cerbone, M., Morlando, M., Schiattarella, A., Colacurci, N., De Franciscis, P., Cataneo, I., Lenzi, M., Sandri, F., Buscemi, R., Gattei, G., Sala, F. D., Valori, E., Rovellotti, M. C., Done, E., Faron, G., Gucciardo, L., Esposito, V., Vena, F., Giancotti, A., Brunelli, R., Muzii, L., Nappi, L., Sorrentino, F., Liberati, M., Buca, D., Leombroni, M., Di Sebastiano, F., Franchi, M., Ianniciello, Q. C., Garzon, S., Petriglia, G., Borrello, L., Nieto-Calvache, A. J., Burgos-Luna, J. M., Kadji, C., Carlin, A., Bevilacqua, E., Moucho, M., Viana Pinto, P., Figueiredo, R., Morales Rosello, J., Loscalzo, G., Martinez-Varea, A., Diago, V., Jimenez Lopez, J. S., Aykanat, A. Y., Cosma, S., Carosso, A., Benedetto, C., Bermejo, A., Feuerschuette, O. H. M., Uyaniklar, O., Ocakouglu, S. R., Atak, Z., Gunduz, R., Haberal, E. T., Froessler, B., Parange, A., Palm, P., Samardjiski, I., Taccaliti, C., Okuyan, E., Daskalakis, G., de Sa, R. A. M., Pittaro, A., Gonzalez-Duran, M. L., Guisan, A. C., Genc, S. O., Zlatohlavkova, B., Piqueras, A. L., Oliva, D. E., Cil, A. P., Api, O., Antsaklis, P., Ples, L., Kyvernitakis, I., Maul, H., Malan, M., Lila, A., Granese, R., Ercoli, A., Zoccali, G., Villasco, A., Biglia, N., Madalina, C., Costa, E., Daelemans, C., Pintiaux, A., Cueto, E., Hadar, E., Dollinger, S., Brzezinski-Sinai, N. A., Huertas, E., Arango, P., Sanchez, A., Schvartzman, J. A., Cojocaru, L., Turan, S., Turan, O., Di Dedda, M. C., Molpeceres, R. G., Zdjelar, S., Premru-Srsen, T., Kornhauser-Cerar, L., Druskovic, M., De Robertis, V., Stefanovic, V., Nupponen, I., Nelskyla, K., Khodjaeva, Z., Gorina, K. A., Sukhikh, G. T., Maruotti, G. M., Visentin, S., Cosmi, E., Ferrari, J., Gatti, A., Luvero, D., Angioli, R., Puri, L., Palumbo, M., D'Urso, G., Colaleo, F., Rapisarda, A. M. C., Carbone, I. F., Manzoli, L., Flacco, M. E., Nazzaro, G., Locci, M., Guida, M., Sardo, A. D. S., Panici, P. B., Khalil, A., Berghella, V., Bifulco, G., Scambia, G., Zullo, F., D'Antonio, F., José Rodríguez Suárez, María, Maria Gambacorti-Passerini, Zita, de Los Angeles Anaya Baz, María, Vanessa Aguilar Galán, Esther, Cuñarro López, Yolanda, Antonio De León Luis, Juan, Cueto Hernández, Ignacio, Battista Luca Schera, Giovanni, Nunzia Della Gatta, Anna, Catello Di Donna, Mariano, Giulia Lombana Marino, Maria, Simone Laganà, Antonio, Laurita Longo, Valentina, Mercado-Olivares, Felipe, Della Sala, Francesca, Cristina Rovellotti, Maria, Cesare Ianniciello, Quintino, Josè Nieto-Calvache, Albaro, Manuel Burgos-Luna, Juan, Viana, Pedro, Martinez-Varea, Alicia, S Jimenez Lopez, Jesú, Yeliz Aykanat, Alicia, DI BENEDETTO, Chiara, Henrique May Feuerschuette, Otto, Rahimli Ocakouglu, Sakine, Tustas Haberal, Esra, Augusto Moreira de Sa, Renato, Luisa Gonzalez-Duran, Maria, Concheiro Guisan, Ana, Özlem Genç, Şerife, Luengo Piqueras, Anna, Esteban Oliva, Dolore, Pelin Cil, Aylin, Gül Yapar Eyi, Elif, A Brzezinski-Sinai, Noa, Alfonso Schvartzman, Javier, Carmela Di Dedda, Maria, Garrote Molpeceres, Rebeca, Premru-Srsen, Tanja, Kornhauser-Cerar, Lilijana, A Gorina, Ksenia, T Sukhikh, Gennady, Maruotti, GIUSEPPE MARIA, Maria Chiara Rapisarda, Agnese, Floriana Carbone, Ilma, Elena Flacco, Maria, DI SPIEZIO SARDO, Attilio, Benedetti Panici, Pierluigi, Saccone G., Sen C., Di Mascio D., Galindo A., Grunebaum A., Yoshimatsu J., Stanojevic M., Kurjak A., Chervenak F., Suarez M.J.R., Gambacorti-Passerini Z.M., de los Angeles Anaya Baz M., Galan E.V.A., Lopez Y.C., Luis J.A.D.L., Hernandez I.C., Herraiz I., Villalain C., Venturella R., Rizzo G., Mappa I., Gerosolima G., Hellmeyer L., Konigbauer J., Ameli G., Frusca T., Volpe N., Schera G.B.L., Fieni S., Esposito E., Simonazzi G., Di Donna G., Youssef A., Gatta A.N.D., Di Donna M.C., Chiantera V., Buono N., Sozzi G., Greco P., Morano D., Bianchi B., Marino M.G.L., Laraud F., Ramone A., Cagnacci A., Barra F., Gustavino C., Ferrero S., Ghezzi F., Cromi A., Lagana A.S., Longo V.L., Stollagli F., Sirico A., Lanzone A., Driul L., Cecchini F., Xodo S., Rodriguez B., Mercado-Olivares F., Elkafrawi D., Sisti G., Esposito R., Coviello A., Cerbone M., Morlando M., Schiattarella A., Colacurci N., De Franciscis P., Cataneo I., Lenzi M., Sandri F., Buscemi R., Gattei G., Sala F.D., Valori E., Rovellotti M.C., Done E., Faron G., Gucciardo L., Esposito V., Vena F., Giancotti A., Brunelli R., Muzii L., Nappi L., Sorrentino F., Liberati M., Buca D., Leombroni M., Di Sebastiano F., Franchi M., Ianniciello Q.C., Garzon S., Petriglia G., Borrello L., Nieto-Calvache A.J., Burgos-Luna J.M., Kadji C., Carlin A., Bevilacqua E., Moucho M., Viana Pinto P., Figueiredo R., Morales Rosello J., Loscalzo G., Martinez-Varea A., Diago V., Jimenez Lopez J.S., Aykanat A.Y., Cosma S., Carosso A., Benedetto C., Bermejo A., Feuerschuette O.H.M., Uyaniklar O., Ocakouglu S.R., Atak Z., Gunduz R., Haberal E.T., Froessler B., Parange A., Palm P., Samardjiski I., Taccaliti C., Okuyan E., Daskalakis G., de Sa R.A.M., Pittaro A., Gonzalez-Duran M.L., Guisan A.C., Genc S.O., Zlatohlavkova B., Piqueras A.L., Oliva D.E., Cil A.P., Api O., Antsaklis P., Ples L., Kyvernitakis I., Maul H., Malan M., Lila A., Granese R., Ercoli A., Zoccali G., Villasco A., Biglia N., Madalina C., Costa E., Daelemans C., Pintiaux A., Cueto E., Hadar E., Dollinger S., Brzezinski-Sinai N.A., Huertas E., Arango P., Sanchez A., Schvartzman J.A., Cojocaru L., Turan S., Turan O., Di Dedda M.C., Molpeceres R.G., Zdjelar S., Premru-Srsen T., Kornhauser-Cerar L., Druskovic M., De Robertis V., Stefanovic V., Nupponen I., Nelskyla K., Khodjaeva Z., Gorina K.A., Sukhikh G.T., Maruotti G.M., Visentin S., Cosmi E., Ferrari J., Gatti A., Luvero D., Angioli R., Puri L., Palumbo M., D'Urso G., Colaleo F., Rapisarda A.M.C., Carbone I.F., Manzoli L., Flacco M.E., Nazzaro G., Locci M., Guida M., Sardo A.D.S., Panici P.B., Khalil A., Berghella V., Bifulco G., Scambia G., Zullo F., D'Antonio F., Mother and Child, Surgical clinical sciences, Obstetrics, and Clinical sciences
Subjects: COVID19, medicine.medical_treatment, coronavirus, COVID-19, infection, pregnancy, SARS-CoV-2, Abortion, infectious diseases, law.invention, Cohort Studies, 0302 clinical medicine, law, 3123 Gynaecology and paediatrics, Pregnancy, Obstetrics and Gynaecology, 030212 general & internal medicine, Pregnancy Complications, Infectious, 030219 obstetrics & reproductive medicine, Radiological and Ultrasound Technology, Transmission (medicine), Obstetrics, Pregnancy Outcome, Obstetrics and Gynecology, Coronavirus, SARS-COV-2, General Medicine, Disease 2019 Covid-19, Intensive care unit, 3. Good health, Hospitalization, Intensive Care Units, Maternal Mortality, Settore MED/40, Radiology Nuclear Medicine and imaging, Gestation, Female, coronavirus, Pandemics, Pregnancy, Pregnancy Complications, Infectious, Pregnancy Outcome, Respiration, Artificial, Retrospective Studies, SARS-CoV-2, COVID-19, Infant, Newborn, Intensive Care Units,Maternal Mortality, Infection, Cohort study, Adult, medicine.medical_specialty, NO, 03 medical and health sciences, medicine, Humans, Radiology, Nuclear Medicine and imaging, Pandemics, Retrospective Studies, Mechanical ventilation, business.industry, Infant, Newborn, Infant, Retrospective cohort study, medicine.disease, Respiration, Artificial, coronaviru, Reproductive Medicine, business
Abstract: WOS:000613461600006 PubMed ID: 32926494 Objectives To evaluate the maternal and perinatal outcomes of pregnancies affected by SARS-CoV-2 infection. Methods This was a multinational retrospective cohort study including women with a singleton pregnancy and laboratory-confirmed SARS-CoV-2 infection, conducted in 72 centers in 22 different countries in Europe, the USA, South America, Asia and Australia, between 1 February 2020 and 30 April 2020. Confirmed SARS-CoV-2 infection was defined as a positive result on real-time reverse-transcription polymerase chain reaction (RT-PCR) assay of nasopharyngeal swab specimens. The primary outcome was a composite measure of maternal mortality and morbidity, including admission to the intensive care unit (ICU), use of mechanical ventilation and death. Results In total, 388 women with a singleton pregnancy tested positive for SARS-CoV-2 on RT-PCR of a nasopharyngeal swab and were included in the study. Composite adverse maternal outcome was observed in 47/388 (12.1%) women; 43 (11.1%) women were admitted to the ICU, 36 (9.3%) required mechanical ventilation and three (0.8%) died. Of the 388 women included in the study, 122 (31.4%) were still pregnant at the time of data analysis. Among the other 266 women, six (19.4% of the 31 women with first-trimester infection) had miscarriage, three (1.1%) had termination of pregnancy, six (2.3%) had stillbirth and 251 (94.4%) delivered a liveborn infant. The rate of preterm birth before 37 weeks' gestation was 26.3% (70/266). Of the 251 liveborn infants, 69/251(27.5%) were admitted to the neonatal ICU, and there were five (2.0%) neonatal deaths. The overall rate of perinatal death was 4.1% (11/266). Only one (1/251, 0.4%) infant, born to a mother who tested positive during the third trimester, was found to be positive for SARS-CoV-2 on RT-PCR. Conclusions SARS-CoV-2 infection in pregnant women is associated with a 0.8% rate of maternal mortality, but an 11.1% rate of admission to the ICU. The risk of vertical transmission seems to be negligible. (C) 2020 International Society of Ultrasound in Obstetrics and Gynecology.
Published: 2021

49. Erratum: Search for gravitational waves from Scorpius X-1 in the second Advanced LIGO observing run with an improved hidden Markov model [Phys. Rev. D 100, 122002 (2019)]

Author: S. J. Jadhav, Samuele Cortese, Charlie Hoy, V. Srivastava, M. Fays, Rebecca Fisher, J. Li, Chris A. Collins, T. Hinderer, A. Di Lieto, Rana X. Adhikari, Al Imran Malik, S. J. Chamberlin, M. Vasúth, Nikhil Sarin, Jonathan Cripe, M. Fyffe, Gabriela Gonzalez, K. R. Corley, F. Donovan, C. F. Da Silva Costa, V. Bossilkov, D. Lumaca, M. A. Okada, K. Mason, S. A. Bilgili, J. D. E. Creighton, Soichiro Morisaki, Jun Liu, E. C. Ferreira, Sanjeev Dhurandhar, D. B. Tanner, Sebastiano Bernuzzi, O. Halim, K. W. Tsang, W. Katzman, M. Yvert, R. M. S. Schofield, M. Nery, L. Naticchioni, R. M. Martin, David A. Nichols, M. Korobko, P. J. Veitch, W. A. Campbell, Ettore Majorana, Benjamin J. Owen, J. F. J. van den Brand, J. Junker, S. Sunil, M. Tacca, S. Hochheim, Martin Hendry, Cecilio García-Quirós, P. Ehrens, Paul M. Ricker, H. Khan, T. Prestegard, G. Cho, H. Fong, G. Greco, M. Bitossi, G. Bergmann, P. A. Altin, Antonios Kontos, S. Walsh, J. G. Bartlett, Márton Tápai, P.H. Nguyen, Junwei Cao, Y. Boetzel, A. Samajdar, K. Wette, F. Thies, John J. Oh, E. A. M. Muniz, Riccardo Ciolfi, Peter T. H. Pang, B. W. Schulte, L. Xiao, F. Ricci, C. Affeldt, R. Goetz, D. C. Vander-Hyde, C. Adams, A. A. Ciobanu, B. Mours, Mandar Patil, Abhirup Ghosh, Liam Cunningham, Archana Pai, F. Paoletti, Z. B. Etienne, Tristan Briant, P. Ruggi, P. Fulda, S. H. Huttner, A. Mullavey, T. J. N. Nelson, Peter Aufmuth, Gregorio Carullo, R. M. Blair, D. Sigg, T. Di Girolamo, S. W. Ballmer, D. M. Shoemaker, Hua Wang, L. Sun, S. R. P. Mohapatra, J. D. Lough, G. Giordano, K. Toland, D. J. Hofman, M. Punturo, Slawomir Gras, S. W. S. Ng, G. Moreno, S. Kumar, C. Buy, Callum Dale Booth, A. M. Sintes, Andrew Melatos, M. Lorenzini, A. Masserot, S. E. Barclay, J. L. Willis, J. McIver, J. H. Briggs, Mark Hannam, Ofek Birnholtz, S. Ghosh, László Á. Gergely, D. M. Wysocki, A. Macquet, B. Lantz, Daichi Tsuna, R. D. Kennedy, José A. Font, N. Singh, Eric Howell, S. Leavey, Chandra Kant Mishra, R. Bhandare, Piotr Jaranowski, K. Mogushi, N. Bode, D. George, Dániel Barta, R. K. Lanza, P. Dupej, Eric B. Flynn, B. Gateley, Aaron Buikema, R. W. L. Jones, C. C. Wipf, E. J. King, A. Strunk, N. Kijbunchoo, Sheelu Abraham, M. J. Cowart, Hai-Ping Cheng, A. Iess, L. K. Nuttall, S. T. Countryman, Surabhi Sachdev, Christopher J. Moore, S. Biscoveanu, Antoni Ramos-Buades, V. V. Frolov, S. Mitra, Xiaohui Fan, Richard O'Shaughnessy, B. Barr, A. D. Viets, D. Meacher, D. Tuyenbayev, Kevin Barkett, I. Dorrington, I. Di Palma, R. Kirchhoff, B. L. Pearlstone, Kendall Ackley, R. K. Nayak, H. Y. Chia, F. Magaña-Sandoval, A. Allocca, M. F. Carney, Ajay Kumar, Jörg Hennig, Charalampos Markakis, R. Pedurand, Benno Willke, A. Grado, T. Sadecki, W. Ren, S. Grunewald, R. Prasanna, R. L. Ward, P. J. Sutton, Alyssa Garcia, J. H. Romie, P. J. King, J. T. Whelan, K. H. Lai, S. G. Crowder, J. Feicht, Joey Shapiro Key, J. R. Sanders, M. Bawaj, M. M. Hanke, S. B. Anderson, M. R. Ganija, S. Ponrathnam, S. Karki, D. Verkindt, O. Puncken, M. B. Shaner, S. B. Coughlin, A. Neunzert, P.-F. Cohadon, M. Heurs, Reed Essick, Kazuhiro Agatsuma, F. Frasconi, T. Hardwick, D. Steinmeyer, F. Travasso, Michał Bejger, M. Standke, M. Croquette, A. Effler, J. Jiang, A. Perreca, G. Gemme, M. Drago, Guenakh Mitselmakher, Zhihui Du, A. Parida, S. S. Eikenberry, K. E. Ramirez, S. Barnum, Ryan Lynch, D. C. Williams, Sung-Po Chao, R. De Rosa, Kwan-Lok Li, D. Passuello, I. Nardecchia, A. Cirone, Hiroyuki Ohta, Robert J. McCarthy, Tim Dietrich, Jennifer Watchi, Sergio Gaudio, C. J. Richardson, J. Healy, V. Kringel, A. M. Holgado, R. Macas, G. Billingsley, S. Macfoy, N. Mukund, L. R. Cominsky, R. Gustafson, Linqing Wen, R. Flaminio, B. A. Boom, A. M. Sergeev, B. Pang, Z. Tornasi, P. Kumar, S. Kandhasamy, M. Fishbach, B. Sorazu, A. Kutynia, Paul T. Baker, A. K. Lenon, S. Mastrogiovanni, M. Pedraza, F. Cavalier, M. Fitz-Axen, Marcus E. Lower, J. S. Kissel, Hartmut Grote, S. Doravari, A. 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Ballardin, Moritz Mehmet, Kiran Prasai, Alessandra Buonanno, C.-J. Haster, Gabrielle Allen, J.-M. Isac, F. Marion, N. Leroy, Nancy Aggarwal, Zahoor Ali Khan, M. Phelps, S. Babak, Alexander C. Jenkins, Xie Chen, A. Markowitz, S. Vitale, G. Dálya, M. Laxen, Anchal Gupta, F. Y. Khalili, Robert L. Byer, Stuart Reid, F. J. Hayes, Jacob Scheuer, B. Bécsy, M. Kasprzack, Bala R. Iyer, S. S. Y. Chua, S. McCormick, C. Casentini, G. Wang, L. Matone, Vuk Mandic, Neil J. Cornish, M. J. Szczepańczyk, Denis Martynov, Marco Bazzan, F-L. Lin, D. J. McManus, C. Ingram, L. Pinard, B. R. Hall, Héctor Estellés, N. Letendre, Alec Mishkin, R. Cavalieri, I. Dave, C. Talbot, E. J. Daw, Maurizio Canepa, Antonio Marquina, Rosa Poggiani, V. Frey, A. K. Mehta, E. K. Wessel, S. Farinon, P. Raffai, T. L. Lam, Alessandro Longo, Richard J. Oram, François Bondu, F. Badaracco, Daniel E. Holz, B. J. J. Slagmolen, B. Patricelli, D. S. Wu, Margaret Millhouse, N. Sennett, Patrick Godwin, K. L. Dooley, Marta Colleoni, J. A. 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Green, E. E. Cowan, B. F. Whiting, J. Casanueva Diaz, P. Schale, C. Van Den Broeck, E. Sowell, T. Zhang, Thibaut Jacqmin, T. Regimbau, C. I. Torrie, M. Saleem, M. Oliver, Douglas Davis, Geraint Pratten, D. Bersanetti, G. Ashton, J. V. van Heijningen, Yu Wang, Francisco Hernandez Vivanco, Eric Thrane, C. Michel, T. D. Knowles, F. Ohme, F. Cleva, M. P. Ross, T. B. Edo, M. Pichot, Maximiliano Isi, E. M. Gretarsson, Ying Guo, D. Beniwal, Peter Fritschel, Wenxiao Wang, M. Masso-Reid, K. C. Cannon, S. Kwang, L. E. Sanchez, Enrico Calloni, G. Traylor, Thomas Corbitt, L. Salconi, C. A. Costa, Laura Cadonati, D. A. Steer, L. Kleybolte, Chad Hanna, A. Bramley, C. Kimball, J. Oberling, M. Pirello, J. Bidler, F. Nocera, C. Zhao, Milan Gupta, G. Mendell, Laboratoire des matériaux avancés (LMA), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Astrophysique Relativiste Théories Expériences Métrologie Instrumentation Signaux (ARTEMIS), Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Institut des Fonctions Optiques pour les Technologies de l'informatiON (Institut FOTON), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-École Nationale Supérieure des Sciences Appliquées et de Technologie (ENSSAT)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Laboratoire Kastler Brossel (LKB [Collège de France]), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Collège de France (CdF (institution)), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL), Institut des Hautes Etudes Scientifiques (IHES), IHES, LIGO Scientific, VIRGO, Abbott, B. 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R., Thorne, K. A., Thrane, E., Tiwari, S., Tiwari, V., Toland, K., Tonelli, M., Tornasi, Z., Torres-Forne, A., Torrie, C. I., Toyra, D., Travasso, F., Traylor, G., Tringali, M. C., Trovato, A., Trozzo, L., Trudeau, R., Tsang, K. W., Tse, M., Tso, R., Tsukada, L., Tsuna, D., Tuyenbayev, D., Ueno, K., Ugolini, D., Unnikrishnan, C. S., Urban, A. L., Usman, S. A., Vahlbruch, H., Vajente, G., Valdes, G., Van Bakel, N., Van Beuzekom, M., Van Den Brand, J. F. J., Van Den Broeck, C., Vander-Hyde, D. C., Van Heijningen, J. V., Van Der Schaaf, L., Van Veggel, A. A., Vardaro, M., Varma, V., Vass, S., Vasuth, M., Vecchio, A., Vedovato, G., Veitch, J., Veitch, P. J., Venkateswara, K., Venugopalan, G., Verkindt, D., Vetrano, F., Vicere, A., Viets, A. D., Vine, D. J., Vinet, J. -Y., Vitale, S., Vo, T., Vocca, H., Vorvick, C., Vyatchanin, S. P., Wade, A. R., Wade, L. E., Wade, M., Walet, R., Walker, M., Wallace, L., Walsh, S., Wang, G., Wang, H., Wang, J. Z., Wang, W. H., Wang, Y. F., Ward, R. 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Subjects: Physics, data analysis method, erratum, 010308 nuclear & particles physics, Gravitational wave, Scorpius X-1, LIGO, gravitational radiation, gravitational radiation: direct detection, 01 natural sciences, gravitational radiation detector, Theoretical physics, cosmic rays, binary: spin, gravitational radiation: emission, 0103 physical sciences, [PHYS.GRQC]Physics [physics]/General Relativity and Quantum Cosmology [gr-qc], Experiments in gravity, X-ray: binary, Hidden Markov model, numerical calculations, 010303 astronomy & astrophysics, cosmology
Abstract: International audience; We present results from a semicoherent search for continuous gravitational waves from the low-mass x-ray binary Scorpius X-1, using a hidden Markov model (HMM) to track spin wandering. This search improves on previous HMM-based searches of LIGO data by using an improved frequency domain matched filter, the J-statistic, and by analyzing data from Advanced LIGO’s second observing run. In the frequency range searched, from 60 to 650 Hz, we find no evidence of gravitational radiation. At 194.6 Hz, the most sensitive search frequency, we report an upper limit on gravitational wave strain (at 95% confidence) of h095%=3.47×10-25 when marginalizing over source inclination angle. This is the most sensitive search for Scorpius X-1, to date, that is specifically designed to be robust in the presence of spin wandering.
Published: 2021
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50. New Insights into Physical Science Vol. 10

Author: B. D'Angelo, Felice Sorrentino, Bob W. N. J. Ursem, Md. Samiul Haque, Thomas F. Valone, V. Sequino, M. Bawaj, V. E. Shapiro, J. P. Zendri, Uzi Notev, Maria Vilenchik, L. Naticchioni, B. Garaventa, Lev Z. Vilenchik, G. Somashekhara Somashekhara, Floyd. L. Williams, Jurgen Michael Honig, C. Nguyen, Boris Sedunov, M. De Laurentis, Ross D. Hoehn, Daniel Sepunaru, Alexander Alexandrovich Antonov, S. Di Pace, G S Shivaprasanna, and I. Khan
Subjects: Engineering, business.industry, Physical science, Engineering ethics, business
Published: 2020
Full Text: View/download PDF

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