1. Volumetric alterations in the basal ganglia in autism Spectrum disorder: A systematic review.
- Author
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de Medeiros Marcos, Gabriel Victor Teodoro, Feitosa, Deymisson Damitene Martins, Paiva, Karina Maia, Oliveira, Rodrigo Freire, da Rocha, Gabriel Sousa, de Medeiros Guerra, Luís Marcos, de Araújo, Dayane Pessoa, Goes, Hosana Mirelle, Costa, Silva, de Oliveira, Lucidio Clebeson, Guzen, Fausto Pierdoná, de Souza Júnior, José Edvan, de Moura Freire, Marco Aurélio, de Aquino, Antonio Carlos Queiroz, de Gois Morais, Paulo Leonardo Araújo, and de Paiva Cavalcanti, José Rodolfo Lopes
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AUTISM spectrum disorders , *BASAL ganglia , *NEURAL circuitry , *BRAIN anatomy , *BASAL ganglia diseases - Abstract
Introduction: Recent research indicates that some brain structures show alterations in conditions such as Autism Spectrum Disorder (ASD). Among them, are the basal ganglia that are involved in motor, cognitive and behavioral neural circuits. Objective: Review the literature that describes possible volumetric alterations in the basal ganglia of individuals with ASD and the impacts that these changes have on the severity of the condition. Methodology: This systematic review was registered in the design and reported according to the PRISMA Items and registered in PROSPERO (CRD42023394787). The study analyzed data from published clinical, case‐contemplate, and cohort trials. The following databases were consulted: PubMed, Embase, Scopus, and Cochrane Central Register of Controlled Trials, using the Medical Subject Titles (MeSH) "Autism Spectrum Disorder" and "Basal Ganglia". The last search was carried out on February 28, 2023. Results: Thirty‐five eligible articles were collected, analyzed, and grouped according to the levels of alterations. Conclusion: The present study showed important volumetric alterations in the basal ganglia in ASD. However, the examined studies have methodological weaknesses that do not allow generalization and correlation with ASD manifestations. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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