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6. [In vitro studies of the adsorption behavior of Wofatit Y 88 in relation to various drugs].

Author

Demme U, Günther K, Werner R, Schwachula G, Kehnscherper R, Stein G, Feistel L, and Junge W

Subjects
Adsorption, Barbiturates analogs & derivatives, Barbiturates pharmacokinetics, Blood Flow Velocity physiology, Humans, Metabolic Clearance Rate physiology, Methaqualone pharmacokinetics, Phenobarbital pharmacokinetics, Pyridones pharmacokinetics, Hemoperfusion methods, Hypnotics and Sedatives pharmacokinetics, Polystyrenes
Abstract

The adsorber Wofatit Y 88 (VEB Chemiekombinat Bitterfeld) was tested regarding its adsorption properties in comparison with Hämoresin (B. Braun, Melsungen, FRG) Hemosorbent SKN-2K (USSR) and the own product Wofatit UH 91. As adsorptives the hypnotics Metaqualon, Pyrithyldion, Crotylbarbital and Phenobarbital were used. The investigation have been performed in a single-pass system in a relation of 1:25 to the clinical practice conditions. The concentration measurements to the estimation of adsorbed amounts were made by UV-VIS spectrometry. It was found that Wofatit Y 88 is superior to Hämoresin with regard to adsorbed amounts and adsorption speed. For all drugs Wofatit Y 88 was superior to UH 91.

Published
1990

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