Author: "Feige, M." - Searchworks@Jio Institute Digital Library Search Results

Your search keyword '"Feige, M."' showing total 40 results

Start Over Author "Feige, M."

40 results on '"Feige, M."'

1. The variability patterns of the TeV blazar PG 1553+113 from a decade of MAGIC and multi-band observations

Author: MAGIC Collaboration, Abe, H., Abe, S., Abhir, J., Acciari, V. A., Agudo, I., Aniello, T., Ansoldi, S., Antonelli, L. A., Engels, A. Arbet, Arcaro, C., Artero, M., Asano, K., Baack, D., Babić, A., Baquero, A., de Almeida, U. Barres, Batković, I., Baxter, J., González, J. Becerra, Bernardini, E., Bernete, J., Berti, A., Besenrieder, J., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Bošnjak, Ž., Burelli, I., Busetto, G., Campoy-Ordaz, A., Carosi, A., Carosi, R., Carretero-Castrillo, M., Castro-Tirado, A. J., Chai, Y., Cifuentes, A., Cikota, S., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Amico, G., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Del Popolo, A., Delfino, M., Delgado, J., Mendez, C. Delgado, Depaoli, D., Di Pierro, F., Di Venere, L., Prester, D. Dominis, Donini, A., Dorner, D., Doro, M., Elsaesser, D., Emery, G., Escudero, J., Fariña, L., Fattorini, A., Foffano, L., Font, L., Fukami, S., Fukazawa, Y., López, R. J. García, Gasparyan, S., Gaug, M., Paiva, J. G. Giesbrecht, Giglietto, N., Giordano, F., Gliwny, P., Grau, R., Green, J. G., Hadasch, D., Hahn, A., Heckmann, L., Herrera, J., Hovatta, T., Hrupec, D., Hütten, M., Imazawa, R., Inada, T., Iotov, R., Ishio, K., Martínez, I. Jiménez, Jormanainen, J., Kerszberg, D., Kluge, G. W., Kobayashi, Y., Kouch, P. M., Kubo, H., Kushida, J., Lezáun, M. Láinez, Lamastra, A., Leone, F., Lindfors, E., Liodakis, I., Lombardi, S., Longo, F., López-Moya, M., López-Oramas, A., Loporchio, S., Lorini, A., Fraga, B. Machado de Oliveira, Majumdar, P., Makariev, M., Maneva, G., Mang, N., Manganaro, M., Mannheim, K., Mariotti, M., Martínez, M., Martínez-Chicharro, M., Mas-Aguilar, A., Mazin, D., Menchiari, S., Mender, S., Miceli, D., Miener, T., Miranda, J. M., Mirzoyan, R., González, M. Molero, Molina, E., Mondal, H. A., Moralejo, A., Morcuende, D., Nakamori, T., Nanci, C., Neustroev, V., Nigro, C., Nikolić, L., Nilsson, K., Nishijima, K., Ekoume, T. Njoh, Noda, K., Nozaki, S., Ohtani, Y., Okumura, A., Otero-Santos, J., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavlović, D., Persic, M., Pihet, M., Pirola, G., Podobnik, F., Moroni, P. G. Prada, Prandini, E., Principe, G., Priyadarshi, C., Rhode, W., Ribó, M., Rico, J., Righi, C., Sahakyan, N., Saito, T., Satalecka, K., Saturni, F. G., Schleicher, B., Schmidt, K., Schmuckermaier, F., Schubert, J. L., Schweizer, T., Sciaccaluga, A., Sitarek, J., Spolon, A., Stamerra, A., Strišković, J., Strom, D., Suda, Y., Suutarinen, S., Tajima, H., Takeishi, R., Tavecchio, F., Temnikov, P., Terauchi, K., Terzić, T., Teshima, M., Tosti, L., Truzzi, S., Tutone, A., Ubach, S., van Scherpenberg, J., Ventura, S., Verguilov, V., Viale, I., Vigorito, C. F., Vitale, V., Walter, R., Wunderlich, C., Yamamoto, T., collaborators, MWL, Jermak, H., Steele, I. A., Smith, P. S., Blinov, D., Raiteri, C. M., Villata, M., Mirzaqulov, D. O., Kurtanidze, S. O., Carosati, D., Savchenko, S. S., Acosta-Pulido, J. A., Borman, G. A., Bozhilov, V., Carnerero, M. I., Chigladze, R. A., Damljanovic, G., Ehgamberdiev, S. A., Feige, M., Grishina, T. S., Gupta, A. C., Hagen-Thorn, V. A., Ibryamov, S., Ivanidze, R. Z., Jorstad, S. G., Kania, J., Kimeridze, G. N., Kopatskaya, E. N., Kopp, M., Kunkel, L., Kurtanidze, O. M., Larionov, V. M., Larionova, E. G., Larionova, L. V., Lorey, C., Marchini, A., Marscher, A. P., Minev, M., Morozova, D. A., Nikolashvili, M. G., Ovcharov, E., Reinhart, D., Sadun, A. C., Scherbantin, A., Schneider, L., Semkov, E., Sigua, L. A., Steineke, R., Troitskaya, Yu. V., Troitskiy, I. S., Valcheva, A., Vasilyev, A. A., Vince, O., Zaharieva, E., Zottmann, N., Kiehlmann, S., Readhead, A., Max-Moerbeck, W., Reeves, R. A., Sandrinelli, A., Ramazani, V. Fallah, Giroletti, M., Righini, S., Marchili, N., Patricelli, B., Ghirlanda, G., and Lico, R.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: PG 1553+113 is one of the few blazars with a convincing quasi-periodic emission in the gamma-ray band. The source is also a very high-energy (VHE; >100 GeV) gamma-ray emitter. To better understand its properties and identify the underlying physical processes driving its variability, the MAGIC Collaboration initiated a multiyear, multiwavelength monitoring campaign in 2015 involving the OVRO 40-m and Medicina radio telescopes, REM, KVA, and the MAGIC telescopes, Swift and Fermi satellites, and the WEBT network. The analysis presented in this paper uses data until 2017 and focuses on the characterization of the variability. The gamma-ray data show a (hint of a) periodic signal compatible with literature, but the X-ray and VHE gamma-ray data do not show statistical evidence for a periodic signal. In other bands, the data are compatible with the gamma-ray period, but with a relatively high p-value. The complex connection between the low and high-energy emission and the non-monochromatic modulation and changes in flux suggests that a simple one-zone model is unable to explain all the variability. Instead, a model including a periodic component along with multiple emission zones is required., Comment: Accepted for publication in Monthly Notices of the Royal Astronomical Society. 19 pages, 9 figures. Corresponding authors: Elisa Prandini, Antonio Stamerra, Talvikki Hovatta
Published: 2024
Full Text: View/download PDF

2. Extreme photometric and polarimetric variability of blazar S4 0954+65 at its maximum optical and $\gamma$-ray brightness levels

Author: Raiteri, C. M., Villata, M., Carnerero, M. I., Savchenko, S. S., Kurtanidze, S. O., Vlasyuk, V. V., Marchini, A., Matsumoto, K., Lorey, C., Joner, M. D., Gazeas, K., Carosati, D., Mirzaqulov, D. O., Pulido, J. A. Acosta, Agudo, I., Bachev, R., Benítez, E., Borman, G. A., Calcidese, P., Chen, W. P., Damljanovic, G., Ehgamberdiev, S. A., Elsässer, D., Feige, M., Frasca, A., Gaur, H., Grishina, T. S., Gupta, A. C., Hiriart, D., Holland, M., Horst, B., Ibryamov, S., Ivanidze, R. Z., Jensen, J., Jithesh, V., Jovanovic, M. D., Kiehlmann, S., Kimeridze, G. N., Kishore, S., Kopatskaya, E. N., Kurtanidze, O. M., Larionova, E. G., Lin, H. C., Mannheim, K., Marinelli, C., Reyes, J. Moreira, Morozova, D. A., Nikolashvili, M. G., Reinhart, D., Romanov, F. D., Semkov, E., Seufert, J., Shishkina, E. V., Sigua, L. A., Skalidis, R., Spiridonova, O. I., Stojanovic, M., Strigachev, A., Troitskaya, Y. V., Troitskiy, I. S., Tsai, A., Vasilyev, A. A., Vince, O., Vrontaki, K., Wani, K., Watts, D., and Zhovtan, A. V.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: In 2022 the BL Lac object S4 0954+65 underwent a major variability phase, reaching its historical maximum brightness in the optical and $\gamma$-ray bands. We present optical photometric and polarimetric data acquired by the Whole Earth Blazar Telescope (WEBT) Collaboration from 2022 April 6 to July 6. Many episodes of unprecedented fast variability were detected, implying an upper limit to the size of the emitting region as low as $10^{-4}$ parsec. The WEBT data show rapid variability in both the degree and angle of polarization. We analyse different models to explain the polarization behaviour in the framework of a twisting jet model, which assumes that the long-term trend of the flux is produced by variations in the emitting region viewing angle. All the models can reproduce the average trend of the polarization degree, and can account for its general anticorrelation with the flux, but the dispersion of the data requires the presence of intrinsic mechanisms, such as turbulence, shocks, or magnetic reconnection. The WEBT optical data are compared to $\gamma$-ray data from the Fermi satellite. These are analysed with both fixed and adaptive binning procedures. We show that the strong correlation between optical and $\gamma$-ray data without measurable delay assumes different slopes in faint and high brightness states, and this is compatible with a scenario where in faint states we mainly see the imprint of the geometrical effects, while in bright states the synchrotron self-Compton process dominates., Comment: 12 pages, 13 figures, in press for MNRAS
Published: 2023

3. Multi-messenger characterization of Mrk 501 during historically low X-ray and $\gamma$-ray activity

Author: MAGIC collaboration, Abe, H., Abe, S., Acciari, V. A., Agudo, I., Aniello, T., Ansoldi, S., Antonelli, L. A., Engels, A. Arbet, Arcaro, C., Artero, M., Asano, K., Baack, D., Babić, A., Baquero, A., de Almeida, U. Barres, Barrio, J. A., Batković, I., Baxter, J., González, J. Becerra, Bednarek, W., Bernardini, E., Bernardos, M., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Bošnjak, Ž., Burelli, I., Busetto, G., Carosi, R., Carretero-Castrillo, M., Castro-Tirado, A. J., Ceribella, G., Chai, Y., Chilingarian, A., Cikota, S., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Amico, G., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Del Popolo, A., Delfino, M., Delgado, J., Mendez, C. Delgado, Depaoli, D., Di Pierro, F., Di Venere, L., Espiñeira, E. Do Souto, Prester, D. Dominis, Donini, A., Dorner, D., Doro, M., Elsaesser, D., Emery, G., Escudero, J., Ramazani, V. Fallah, Fariña, L., Fattorini, A., Foffano, L., Font, L., Fruck, C., Fukami, S., Fukazawa, Y., López, R. J. García, Garczarczyk, M., Gasparyan, S., Gaug, M., Paiva, J. G. Giesbrecht, Giglietto, N., Giordano, F., Gliwny, P., Godinović, N., Grau, R., Green, D., Green, J. G., Hadasch, D., Hahn, A., Hassan, T., Heckmann, L., Herrera, J., Hrupec, D., Hütten, M., Imazawa, R., Inada, T., Iotov, R., Ishio, K., Martínez, I. Jiménez, Jormanainen, J., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Linhoff, L., Lombardi, S., Longo, F., López-Coto, R., López-Moya, M., López-Oramas, A., Loporchio, S., Lorini, A., Lyard, E., Fraga, B. Machado de Oliveira, Majumdar, P., Makariev, M., Maneva, G., Mang, N., Manganaro, M., Mangano, S., Mannheim, K., Mariotti, M., Martínez, M., Mas-Aguilar, A., Mazin, D., Menchiari, S., Mender, S., Mićanović, S., Miceli, D., Miener, T., Miranda, J. M., Mirzoyan, R., Molina, E., Mondal, H. A., Moralejo, A., Morcuende, D., Moreno, V., Nakamori, T., Nanci, C., Nava, L., Neustroev, V., Rosillo, M. Nievas, Nigro, C., Nilsson, K., Nishijima, K., Ekoume, T. Njoh, Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Okumura, A., Otero-Santos, J., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavletić, L., Persic, M., Pihet, M., Pirola, G., Podobnik, F., Moroni, P. G. Prada, Prandini, E., Principe, G., Priyadarshi, C., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Saturni, F. G., Schleicher, B., Schmidt, K., Schmuckermaier, F., Schubert, J. L., Schweizer, T., Sitarek, J., Sliusar, V., Sobczynska, D., Spolon, A., Stamerra, A., Strišković, J., Strom, D., Strzys, M., Suda, Y., Surić, T., Tajima, H., Takahashi, M., Takeishi, R., Tavecchio, F., Temnikov, P., Terauchi, K., Terzić, T., Teshima, M., Tosti, L., Truzzi, S., Tutone, A., Ubach, S., van Scherpenberg, J., Acosta, M. Vazquez, Ventura, S., Verguilov, V., Viale, I., Vigorito, C. F., Vitale, V., Vovk, I., Walter, R., Will, M., Wunderlich, C., Yamamoto, T., Zarić, D., groups, Other, collaborations, Cerruti, M., Acosta-Pulido, J. A., Apolonio, G., Bachev, R., Baloković, M., Benítez, E., Björklund, I., Bozhilov, V., Brown, L. F., Bugg, A., Carbonell, W., Carnerero, M. I., Carosati, D., Casadio, C., Chamani, W., Chen, W. P., Chigladze, R. A., Damljanovic, G., Epps, K., Erkenov, A., Feige, M., Finke, J., Fuentes, A., Gazeas, K., Giroletti, M., Grishina, T. S., Gupta, A. C., Gurwell, M. A., Heidemann, E., Hiriart, D., Hou, W. J., Hovatta, T., Ibryamov, S., Joner, M. D., Jorstad, S. G., Kania, J., Kiehlmann, S., Kimeridze, G. N., Kopatskaya, E. N., Kopp, M., Korte, M., Kotas, B., Koyama, S., Kramer, J. A., Kunkel, L., Kurtanidze, S. O., Kurtanidze, O. M., Lähteenmäki, A., López, J. M., Larionov, V. M., Larionova, E. G., Larionova, L. V., Leto, C., Lorey, C., Mújica, R., Madejski, G. M., Marchili, N., Marscher, A. P., Minev, M., Modaressi, A., Morozova, D. A., Mufakharov, T., Myserlis, I., Nikiforova, A. A., Nikolashvili, M. G., Ovcharov, E., Perri, M., Raiteri, C. M., Readhead, A. C. S., Reimer, A., Reinhart, D., Righini, S., Rosenlehner, K., Sadun, A. C., Savchenko, S. S., Scherbantin, A., Schneider, L., Schoch, K., Seifert, D., Semkov, E., Sigua, L. A., Singh, C., Sola, P., Sotnikova, Y., Spencer, M., Steineke, R., Stojanovic, M., Strigachev, A., Tornikoski, M., Traianou, E., Tramacere, A., Troitskaya, Yu. V., Troitskiy, I. S., Trump, J. B., Tsai, A., Valcheva, A., Vasilyev, A. A., Verrecchia, F., Villata, M., Vince, O., Vrontaki, K., Weaver, Z. R., Zaharieva, E., and Zottmann, N.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We study the broadband emission of Mrk 501 using multi-wavelength observations from 2017 to 2020 performed with a multitude of instruments, involving, among others, MAGIC, Fermi-LAT, NuSTAR, Swift, GASP-WEBT, and OVRO. Mrk 501 showed an extremely low broadband activity, which may help to unravel its baseline emission. Nonetheless, significant flux variations are detected at all wavebands, with the highest occurring at X-rays and very-high-energy (VHE) $\gamma$-rays. A significant correlation ($>$3$\sigma$) between X-rays and VHE $\gamma$-rays is measured, supporting leptonic scenarios to explain the variable parts of the emission, also during low activity. This is further supported when we extend our data from 2008 to 2020, and identify, for the first time, significant correlations between Swift-XRT and Fermi-LAT. We additionally find correlations between high-energy $\gamma$-rays and radio, with the radio lagging by more than 100 days, placing the $\gamma$-ray emission zone upstream of the radio-bright regions in the jet. Furthermore, Mrk 501 showed a historically low activity in X-rays and VHE $\gamma$-rays from mid-2017 to mid-2019 with a stable VHE flux ($>$0.2 TeV) of 5% the emission of the Crab Nebula. The broadband spectral energy distribution (SED) of this 2-year-long low-state, the potential baseline emission of Mrk 501, can be characterized with one-zone leptonic models, and with (lepto)-hadronic models fulfilling neutrino flux constraints from IceCube. We explore the time evolution of the SED towards the low-state, revealing that the stable baseline emission may be ascribed to a standing shock, and the variable emission to an additional expanding or traveling shock., Comment: 55 pages, 30 figures, 14 tables, accepted by APJS. Corresponding authors are L. Heckmann, D. Paneque, S. Gasparyan, M. Cerruti, and N. Sahakyan
Published: 2022
Full Text: View/download PDF

4. Investigation of the correlation patterns and the Compton dominance variability of Mrk 421 in 2017

Author: MAGIC Collaboration, Acciari, V. A., Ansoldi, S., Antonelli, L. A., Engels, A. Arbet, Artero, M., Asano, K., Babić, A., Baquero, A., de Almeida, U. Barres, Barrio, J. A., Batković, I., González, J. Becerra, Bednarek, W., Bellizzi, L., Bernardini, E., Bernardos, M., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Blanch, O., Bošnjak, Ž., Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colak, S. M., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Amico, G., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Mendez, C. Delgado, Depaoli, D., Di Pierro, F., Di Venere, L., Espiñeira, E. Do Souto, Prester, D. Dominis, Donini, A., Doro, M., Ramazani, V. Fallah, Fattorini, A., Ferrara, G., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., López, R. J. García, Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinović, N., Green, J. G., Green, D., Hadasch, D., Hahn, A., Heckmann, L., Herrera, J., Hoang, J., Hrupec, D., Hütten, M., Inada, T., Inoue, S., Ishio, K., Iwamura, Y., Jiménez, I., Jormanainen, J., Jouvin, L., Kajiwara, Y., Karjalainen, M., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., López-Coto, R., López-Moya, M., López-Oramas, A., Loporchio, S., Fraga, B. Machado de Oliveira, Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Maraschi, L., Mariotti, M., Martínez, M., Mazin, D., Menchiari, S., Mender, S., Mićanović, S., Miceli, D., Miener, T., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Neustroev, V., Nigro, C., Nilsson, K., Nishijima, K., Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavletić, L., Peñil, P., Perennes, C., Persic, M., Moroni, P. G. Prada, Prandini, E., Priyadarshi, C., Puljak, I., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Saturni, F. G., Schmidt, K., Schweizer, T., Sitarek, J., Šnidarić, I., Sobczynska, D., Spolon, A., Stamerra, A., Strom, D., Strzys, M., Suda, Y., Surić, T., Takahashi, M., Tavecchio, F., Temnikov, P., Terzić, T., Teshima, M., Tosti, L., Truzzi, S., Tutone, A., Ubach, S., van Scherpenberg, J., Vanzo, G., Acosta, M. Vazquez, Ventura, S., Verguilov, V., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Wunderlich, C., Zarić, D., Collaboration, FACT, Baack, D., Balbo, M., Biederbeck, N., Biland, A., Bretz, T., Buss, J., Dorner, D., Eisenberger, L., Elsaesser, D., Hildebrand, D., Iotov, R., Mannheim, K., Neise, D., Noethe, M., Paravac, A., Rhode, W., Schleicher, B., Sliusar, V., Walter, R., groups, Other, collaborations, D'Ammando, F., Horan, D., Lien, A. Y., Baloković, M., Madejski, G. M., Perri, M., Verrecchia, F., Leto, C., Lähteenmäki, A., Tornikoski, M., Ramakrishnan, V., Järvelä, E., Vera, R. J. C., Villata, M., Raiteri, C. M., Gupta, A. C., Pandey, A., Fuentes, A., Agudo, I., Casadio, C., Semkov, E., Ibryamov, S., Marchini, A., Bachev, R., Strigachev, A., Ovcharov, E., Bozhilov, V., Valcheva, A., Zaharieva, E., Damljanovic, G., Vince, O., Larionov, V. M., Borman, G. A., Grishina, T. S., Hagen-Thorn, V. A., Kopatskaya, E. N., Larionova, E. G., Larionova, L. V., Morozova, D. A., Nikiforova, A. A., Savchenko, S. S., Troitskiy, I. S., Troitskaya, Y. V., Vasilyev, A. A., Merkulova, O. A., Chen, W. P., Samal, M., Lin, H. C., Moody, J. W., Sadun, A. C., Jorstad, S. G., Marscher, A. P., Weaver, Z. R., Feige, M., Kania, J., Kopp, M., Kunkel, L., Reinhart, D., Scherbantin, A., Schneider, L., Lorey, C., Acosta-Pulido, J. A., Carnerero, M. I., Carosati, D., Kurtanidze, S. O., Kurtanidze, O. M., Nikolashvili, M. G., Chanishvili, R. G., Chigladze, R. A., Ivanidze, R. Z., Kimeridze, G. N., Sigua, L. A., Joner, M. D., Spencer, M., Giroletti, M., Marchili, N., Righini, S., Rizzi, N., and Bonnoli, G.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We present a detailed characterisation and theoretical interpretation of the broadband emission of the paradigmatic TeV blazar Mrk 421, with special focus on the multi-band flux correlations. The dataset has been collected through an extensive multiwavelength campaign organised between 2016 December and 2017 June. The instruments involved are MAGIC, FACT, Fermi-LAT, Swift, GASP-WEBT, OVRO, Medicina and Mets\"ahovi. Additionally, four deep exposures (several hours long) with simultaneous MAGIC and NuSTAR observations allowed a precise measurement of the falling segments of the two spectral components. The very-high-energy (VHE; E > 100 GeV) gamma rays and X-rays are positively correlated at zero time lag, but the strength and characteristics of the correlation change substantially across the various energy bands probed. The VHE versus X-ray fluxes follow different patterns, partly due to substantial changes in the Compton dominance during a few days without a simultaneous increase in the X-ray flux (i.e. orphan gamma-ray activity). Studying the broadband spectral energy distribution (SED) during the days including NuSTAR observations, we show that these changes can be explained within a one-zone leptonic model with a blob that increases its size over time. Our multi-band correlation study also hints at an anti-correlation between UV/optical and X-ray at a significance higher than 3 sigmas. A VHE flare observed on 2017 February 4 shows gamma-ray variability on multi-hour timescales, with a factor 10 increase in the TeV flux but only a moderate increase in the keV flux. The related broadband SED is better described by a two-zone leptonic scenario rather than by a one-zone scenario. We find that the flare can be produced by the appearance of a compact second blob populated by high energetic electrons spanning a narrow range of Lorentz factors., Comment: 38 pages, 23 figures, accepted for publication in Astronomy and Astrophysics. Corresponding authors: Axel Arbet-Engels, David Paneque
Published: 2021
Full Text: View/download PDF

5. Very-high-energy gamma-rays from the Universe's middle age: detection of the z=0.940 blazar PKS 1441+25 with MAGIC

Author: MAGIC Collaboration, Ahnen, M. L., Ansoldi, S., Antonelli, A., Antoranz, P., Babic, A., Banerjee, B., Bangale, P., de Almeida, U. Barres, Barrio, J. A., Bednarek, W., Bernardini, E., Biassuzzi, B., Biland, A., Blanch, O., Bonnefoy, S., Bonnoli, G., Borracci, F., Bretz, T., Carmona, E., Carosi, A., Chatterjee, A., Clavero, R., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Wilhelmi, E. de Oña, Mendez, C. Delgado, Di Pierro, F., Prester, D. Dominis, Dorner, D., Doro, M., Einecke, S., Glawion, D. Eisenacher, Elsaesser, D., Fernández-Barral, A., Fidalgo, D., Fonseca, M. V., Font, L., Frantzen, K., Fruck, C., Galindo, D., López, R. J. García, Garczarczyk, M., Terrats, D. Garrido, Gaug, M., Giammaria, P., Godinović, N., Muñoz, A. González, Guberman, D., Hahn, A., Hanabata, Y., Hayashida, M., Herrera, J., Hose, J., Hrupec, D., Hughes, G., Idec, W., Kodani, K., Konno, Y., Kubo, H., Kushida, J., La Barbera, A., Lelas, D., Lindfors, E., Lombardi, S., López, M., López-Coto, R., López-Oramas, A., Lorenz, E., Majumdar, P., Makariev, M., Mallot, K., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Marcote, B., Mariotti, M., Martínez, M., Mazin, D., Menzel, U., Miranda, J. M., Mirzoyan, R., Moralejo, A., Moretti, E., Nakajima, D., Neustroev, V., Niedzwiecki, A., Rosillo, M. Nievas, Nilsson, K., Nishijima, K., Noda, K., Orito, R., Overkemping, A., Paiano, S., Palacio, J., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Paredes-Fortuny, X., Persic, M., Poutanen, J., Moroni, P. G. Prada, Prandini, E., Puljak, I., Rhode, W., Ribó, M., Rico, J., Garcia, J. Rodriguez, Saito, T., Satalecka, K., Schultz, C., Schweizer, T., Shore, S. N., Sillanpää, A., Sitarek, J., Snidaric, I., Sobczynska, D., Stamerra, A., Steinbring, T., Strzys, M., Takalo, L., Takami, H., Tavecchio, F., Temnikov, P., Terzić, T., Tescaro, D., Teshima, M., Thaele, J., Torres, D. F., Toyama, T., Treves, A., Verguilov, V., Vovk, I., Ward, J. E., Will, M., Wu, M. H., Zanin, R., Collaboration, FERMI-LAT, Ajello, M., Baldini, L., Barbiellini, G., Bastieri, D., González, J. Becerra, Bellazzini, R., Bissaldi, E., Blandford, R. D., Bonino, R., Bregeon, J., Bruel, P., Buson, S., Caliandro, G. A., Cameron, R. A., Caragiulo, M., Caraveo, P. A., Cavazzuti, E., Chiang, J., Chiaro, G., Ciprini, S., D'Ammando, F., de Palma, F., Desiante, R., Di Venere, L., Domínguez, A., Fusco, P., Gargano, F., Gasparrini, D., Giglietto, N., Giordano, F., Giroletti, M., Grenier, I. A., Guiriec, S., Hays, E., Hewitt, J. W., Jogler, T., Kuss, M., Larsson, S., Li, J., Li, L., Longo, F., Loparco, F., Lovellette, M. N., Lubrano, P., Maldera, S., Mayer, M., Mazziotta, M. N., McEnery, J. E., Mirabal, N., Mizuno, T., Monzani, M. E., Morselli, A., Moskalenko, I. V., Nuss, E., Ojha, R., Ohsugi, T., Omodei, N., Orlando, E., Perkins, J. S., Pesce-Rollins, M., Piron, F., Pivato, G., Porter, T. A., Rainò, S., Rando, R., Razzano, M., Reimer, A., Reimer, O., Sgrò, C., Siskind, E. J., Spada, F., Spandre, G., Spinelli, P., Tajima, H., Takahashi, H., Thayer, J. B., Thompson, D. J., Troja, E., Wood, K. S., Balokovic, M., Berdyugin, A., Carraminana, A., Carrasco, L., Chavushyan, V., Ramazani, V. Fallah, Feige, M., Haarto, S., Haeusner, P., Hovatta, T., Kania, J., Klamt, J., Lähteenmäki, A., Leon-Tavares, J., Lorey, C., Pacciani, L., Porras, A., Recillas, E., Reinthal, R., Tornikoski, M., Wolfert, D., and Zottmann, N.
Subjects: Astrophysics - Astrophysics of Galaxies, Astrophysics - High Energy Astrophysical Phenomena
Abstract: The flat-spectrum radio quasar PKS 1441+25 at a redshift of z = 0.940 is detected between 40 and 250 GeV with a significance of 25.5 {\sigma} using the MAGIC telescopes. Together with the gravitationally lensed blazar QSO B0218+357 (z = 0.944), PKS 1441+25 is the most distant very high energy (VHE) blazar detected to date. The observations were triggered by an outburst in 2015 April seen at GeV energies with the Large Area Telescope on board Fermi. Multi-wavelength observations suggest a subdivision of the high state into two distinct flux states. In the band covered by MAGIC, the variability time scale is estimated to be 6.4 +/- 1.9 days. Modeling the broadband spectral energy distribution with an external Compton model, the location of the emitting region is understood as originating in the jet outside the broad line region (BLR) during the period of high activity, while being partially within the BLR during the period of low (typical) activity. The observed VHE spectrum during the highest activity is used to probe the extragalactic background light at an unprecedented distance scale for ground-based gamma-ray astronomy., Comment: Corresponding Authors: J. Becerra (josefa.becerra@nasa.gov), M. Nievas Rosillo (mnievas@ucm.es), M. Manganaro (manganaro@iac.es), F. Tavecchio (fabrizio.tavecchio@brera.inaf.it) Published in The Astrophysical Journal Letters (ApJL), 2015ApJ...815L..23A, DOI: 10.1088/2041-8205/815/2/L23
Published: 2015
Full Text: View/download PDF

6. Extreme photometric and polarimetric variability of blazar S4 0954+65 at its maximum optical and γ-ray brightness levels

Author: Raiteri, C M, primary, Villata, M, additional, Carnerero, M I, additional, Savchenko, S S, additional, Kurtanidze, S O, additional, Vlasyuk, V V, additional, Marchini, A, additional, Matsumoto, K, additional, Lorey, C, additional, Joner, M D, additional, Gazeas, K, additional, Carosati, D, additional, Mirzaqulov, D O, additional, Acosta Pulido, J A, additional, Agudo, I, additional, Bachev, R, additional, Benítez, E, additional, Borman, G A, additional, Calcidese, P, additional, Chen, W P, additional, Damljanovic, G, additional, Ehgamberdiev, S A, additional, Elsässer, D, additional, Feige, M, additional, Frasca, A, additional, Gaur, H, additional, Grishina, T S, additional, Gupta, A C, additional, Hiriart, D, additional, Holland, M, additional, Horst, B, additional, Ibryamov, S, additional, Ivanidze, R Z, additional, Jensen, J, additional, Jithesh, V, additional, Jovanovic, M D, additional, Kiehlmann, S, additional, Kimeridze, G N, additional, Kishore, S, additional, Kopatskaya, E N, additional, Kurtanidze, O M, additional, Larionova, E G, additional, Lin, H C, additional, Mannheim, K, additional, Marinelli, C, additional, Moreira Reyes, J, additional, Morozova, D A, additional, Nikolashvili, M G, additional, Reinhart, D, additional, Romanov, F D, additional, Semkov, E, additional, Seufert, J, additional, Shishkina, E V, additional, Sigua, L A, additional, Skalidis, R, additional, Spiridonova, O I, additional, Stojanovic, M, additional, Strigachev, A, additional, Troitskaya, Y V, additional, Troitskiy, I S, additional, Tsai, A, additional, Vasilyev, A A, additional, Vince, O, additional, Vrontaki, K, additional, Wani, K, additional, Watts, D, additional, and Zhovtan, A V, additional
Published: 2023
Full Text: View/download PDF

7. Multimessenger Characterization of Markarian 501 during Historically Low X-Ray and γ-Ray Activity

Author: Abe, H., primary, Abe, S., additional, Acciari, V. A., additional, Agudo, I., additional, Aniello, T., additional, Ansoldi, S., additional, Antonelli, L. A., additional, Arbet-Engels, A., additional, Arcaro, C., additional, Artero, M., additional, Asano, K., additional, Baack, D., additional, Babić, A., additional, Baquero, A., additional, de Almeida, U. Barres, additional, Barrio, J. A., additional, Batković, I., additional, Baxter, J., additional, Becerra González, J., additional, Bednarek, W., additional, Bernardini, E., additional, Bernardos, M., additional, Berti, A., additional, Besenrieder, J., additional, Bhattacharyya, W., additional, Bigongiari, C., additional, Biland, A., additional, Blanch, O., additional, Bonnoli, G., additional, Bošnjak, Ž., additional, Burelli, I., additional, Busetto, G., additional, Carosi, R., additional, Carretero-Castrillo, M., additional, Castro-Tirado, A. J., additional, Ceribella, G., additional, Chai, Y., additional, Chilingarian, A., additional, Cikota, S., additional, Colombo, E., additional, Contreras, J. L., additional, Cortina, J., additional, Covino, S., additional, D’Amico, G., additional, D’Elia, V., additional, Da Vela, P., additional, Dazzi, F., additional, De Angelis, A., additional, De Lotto, B., additional, Del Popolo, A., additional, Delfino, M., additional, Delgado, J., additional, Delgado Mendez, C., additional, Depaoli, D., additional, Di Pierro, F., additional, Di Venere, L., additional, Souto Espiñeira, E. Do, additional, Dominis Prester, D., additional, Donini, A., additional, Dorner, D., additional, Doro, M., additional, Elsaesser, D., additional, Emery, G., additional, Escudero, J., additional, Fallah Ramazani, V., additional, Fariña, L., additional, Fattorini, A., additional, Foffano, L., additional, Font, L., additional, Fruck, C., additional, Fukami, S., additional, Fukazawa, Y., additional, García López, R. J., additional, Garczarczyk, M., additional, Gasparyan, S., additional, Gaug, M., additional, Giesbrecht Paiva, J. G., additional, Giglietto, N., additional, Giordano, F., additional, Gliwny, P., additional, Godinović, N., additional, Grau, R., additional, Green, D., additional, Green, J. G., additional, Hadasch, D., additional, Hahn, A., additional, Hassan, T., additional, Heckmann, L., additional, Herrera, J., additional, Hrupec, D., additional, Hütten, M., additional, Imazawa, R., additional, Inada, T., additional, Iotov, R., additional, Ishio, K., additional, Jiménez Martínez, I., additional, Jormanainen, J., additional, Kerszberg, D., additional, Kobayashi, Y., additional, Kubo, H., additional, Kushida, J., additional, Lamastra, A., additional, Lelas, D., additional, Leone, F., additional, Lindfors, E., additional, Linhoff, L., additional, Lombardi, S., additional, Longo, F., additional, López-Coto, R., additional, López-Moya, M., additional, López-Oramas, A., additional, Loporchio, S., additional, Lorini, A., additional, Lyard, E., additional, Machado de Oliveira Fraga, B., additional, Majumdar, P., additional, Makariev, M., additional, Maneva, G., additional, Mang, N., additional, Manganaro, M., additional, Mangano, S., additional, Mannheim, K., additional, Mariotti, M., additional, Martínez, M., additional, Mas-Aguilar, A., additional, Mazin, D., additional, Menchiari, S., additional, Mender, S., additional, Mićanović, S., additional, Miceli, D., additional, Miener, T., additional, Miranda, J. M., additional, Mirzoyan, R., additional, Molina, E., additional, Mondal, H. A., additional, Moralejo, A., additional, Morcuende, D., additional, Moreno, V., additional, Nakamori, T., additional, Nanci, C., additional, Nava, L., additional, Neustroev, V., additional, Nievas Rosillo, M., additional, Nigro, C., additional, Nilsson, K., additional, Nishijima, K., additional, Njoh Ekoume, T., additional, Noda, K., additional, Nozaki, S., additional, Ohtani, Y., additional, Oka, T., additional, Okumura, A., additional, Otero-Santos, J., additional, Paiano, S., additional, Palatiello, M., additional, Paneque, D., additional, Paoletti, R., additional, Paredes, J. M., additional, Pavletić, L., additional, Persic, M., additional, Pihet, M., additional, Pirola, G., additional, Podobnik, F., additional, Moroni, P. G. Prada, additional, Prandini, E., additional, Principe, G., additional, Priyadarshi, C., additional, Rhode, W., additional, Ribó, M., additional, Rico, J., additional, Righi, C., additional, Rugliancich, A., additional, Sahakyan, N., additional, Saito, T., additional, Sakurai, S., additional, Satalecka, K., additional, Saturni, F. G., additional, Schleicher, B., additional, Schmidt, K., additional, Schmuckermaier, F., additional, Schubert, J. L., additional, Schweizer, T., additional, Sitarek, J., additional, Sliusar, V., additional, Sobczynska, D., additional, Spolon, A., additional, Stamerra, A., additional, Strišković, J., additional, Strom, D., additional, Strzys, M., additional, Suda, Y., additional, Surić, T., additional, Tajima, H., additional, Takahashi, M., additional, Takeishi, R., additional, Tavecchio, F., additional, Temnikov, P., additional, Terauchi, K., additional, Terzić, T., additional, Teshima, M., additional, Tosti, L., additional, Truzzi, S., additional, Tutone, A., additional, Ubach, S., additional, van Scherpenberg, J., additional, Acosta, M. Vazquez, additional, Ventura, S., additional, Verguilov, V., additional, Viale, I., additional, Vigorito, C. F., additional, Vitale, V., additional, Vovk, I., additional, Walter, R., additional, Will, M., additional, Wunderlich, C., additional, Yamamoto, T., additional, Zarić, D., additional, Cerruti, M., additional, Acosta-Pulido, J. A., additional, Apolonio, G., additional, Bachev, R., additional, Baloković, M., additional, Benítez, E., additional, Björklund, I., additional, Bozhilov, V., additional, Brown, L. F., additional, Bugg, A., additional, Carbonell, W., additional, Carnerero, M. I., additional, Carosati, D., additional, Casadio, C., additional, Chamani, W., additional, Chen, W. P., additional, Chigladze, R. A., additional, Damljanovic, G., additional, Epps, K., additional, Erkenov, A., additional, Feige, M., additional, Finke, J., additional, Fuentes, A., additional, Gazeas, K., additional, Giroletti, M., additional, Grishina, T. S., additional, Gupta, A. C., additional, Gurwell,, M. A., additional, Heidemann, E., additional, Hiriart, D., additional, Hou, W. J., additional, Hovatta, T., additional, Ibryamov, S., additional, Joner, M. D., additional, Jorstad, S. G., additional, Kania, J., additional, Kiehlmann, S., additional, Kimeridze, G. N., additional, Kopatskaya, E. N., additional, Kopp, M., additional, Korte, M., additional, Kotas, B., additional, Koyama, S., additional, Kramer, J. A., additional, Kunkel, L., additional, Kurtanidze, S. O., additional, Kurtanidze, O. M., additional, Lähteenmäki, A., additional, López, J. M., additional, Larionov, V. M., additional, Larionova, E. G., additional, Larionova, L. V., additional, Leto, C., additional, Lorey, C., additional, Mújica, R., additional, Madejski, G. M., additional, Marchili, N., additional, Marscher, A. P., additional, Minev, M., additional, Modaressi, A., additional, Morozova, D. A., additional, Mufakharov, T., additional, Myserlis, I., additional, Nikiforova, A. A., additional, Nikolashvili, M. G., additional, Ovcharov, E., additional, Perri, M., additional, Raiteri, C. M., additional, Readhead, A. C. S., additional, Reimer, A., additional, Reinhart, D., additional, Righini, S., additional, Rosenlehner, K., additional, Sadun, A. C., additional, Savchenko, S. S., additional, Scherbantin, A., additional, Schneider, L., additional, Schoch, K., additional, Seifert, D., additional, Semkov, E., additional, Sigua, L. A., additional, Singh, C., additional, Sola, P., additional, Sotnikova, Y., additional, Spencer, M., additional, Steineke, R., additional, Stojanovic, M., additional, Strigachev, A., additional, Tornikoski, M., additional, Traianou, E., additional, Tramacere, A., additional, Troitskaya, Yu. V., additional, Troitskiy, I. S., additional, Trump, J. B., additional, Tsai, A., additional, Valcheva, A., additional, Vasilyev, A. A., additional, Verrecchia, F., additional, Villata, M., additional, Vince, O., additional, Vrontaki, K., additional, Weaver, Z. R., additional, Zaharieva, E., additional, and Zottmann, N., additional
Published: 2023
Full Text: View/download PDF

8. The optical behaviour of BL Lacertae at its maximum brightness levels: a blend of geometry and energetics

Author: Raiteri, C M, primary, Villata, M, additional, Jorstad, S G, additional, Marscher, A P, additional, Acosta Pulido, J A, additional, Carosati, D, additional, Chen, W P, additional, Joner, M D, additional, Kurtanidze, S O, additional, Lorey, C, additional, Marchini, A, additional, Matsumoto, K, additional, Mirzaqulov, D O, additional, Savchenko, S S, additional, Strigachev, A, additional, Vince, O, additional, Aceti, P, additional, Apolonio, G, additional, Arena, C, additional, Arkharov, A, additional, Bachev, R, additional, Bader, N, additional, Banfi, M, additional, Bonnoli, G, additional, Borman, G A, additional, Bozhilov, V, additional, Brown, L F, additional, Carbonell, W, additional, Carnerero, M I, additional, Damljanovic, G, additional, Dhiman, V, additional, Ehgamberdiev, S A, additional, Elsaesser, D, additional, Feige, M, additional, Gabellini, D, additional, Galán, D, additional, Galli, G, additional, Gaur, H, additional, Gazeas, K, additional, Grishina, T S, additional, Gupta, A C, additional, Hagen-Thorn, V A, additional, Hallum, M K, additional, Hart, M, additional, Hasuda, K, additional, Heidemann, K, additional, Horst, B, additional, Hou, W-J, additional, Ibryamov, S, additional, Ivanidze, R Z, additional, Jovanovic, M D, additional, Kimeridze, G N, additional, Kishore, S, additional, Klimanov, S, additional, Kopatskaya, E N, additional, Kurtanidze, O M, additional, Kushwaha, P, additional, Lane, D J, additional, Larionova, E G, additional, Leonini, S, additional, Lin, H C, additional, Mannheim, K, additional, Marino, G, additional, Minev, M, additional, Modaressi, A, additional, Morozova, D A, additional, Mortari, F, additional, Nazarov, S V, additional, Nikolashvili, M G, additional, Otero Santos, J, additional, Ovcharov, E, additional, Papini, R, additional, Pinter, V, additional, Privitera, C A, additional, Pursimo, T, additional, Reinhart, D, additional, Roberts, J, additional, Romanov, F D, additional, Rosenlehner, K, additional, Sakamoto, T, additional, Salvaggio, F, additional, Schoch, K, additional, Semkov, E, additional, Seufert, J, additional, Shakhovskoy, D, additional, Sigua, L A, additional, Singh, C, additional, Steineke, R, additional, Stojanovic, M, additional, Tripathi, T, additional, Troitskaya, Y V, additional, Troitskiy, I S, additional, Tsai, A, additional, Valcheva, A, additional, Vasilyev, A A, additional, Vrontaki, K, additional, Weaver, Z R, additional, Wooley, J H F, additional, Zaharieva, E, additional, and Zhovtan, A V, additional
Published: 2023
Full Text: View/download PDF

9. 1350 “TO BE A DEMENTIA-FRIENDLY HOSPITAL, I THINK YOU NEED TO HAVE…” - THE PERSPECTIVES OF PROFESSIONAL DEMENTIA EXPERTS

Author: Manietta, C, primary, Purwins, D, additional, Reinhard, A, additional, Pinkert, C, additional, Fink, L, additional, Feige, M, additional, Knecht, C, additional, and Roes, M, additional
Published: 2023
Full Text: View/download PDF

10. Multiwavelength Observations of the Blazar VER J0521+211 during an Elevated TeV Gamma-Ray State

Author: Abe, H., Abe, S., Acciari, V. A., Agudo, I., Aniello, T., Ansoldi, S., Antonelli, L. A., Arbet Engels, A., Arcaro, C., Artero, M., Asano, K., Baack, D., Babić, A., Baquero, A., Barres de Almeida, U., Barrio, J. A., Batković, I., Baxter, J., Becerra González, J., Bednarek, W., Bernardini, E., Bernardos, M., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Bošnjak, Ž., Burelli, I., Busetto, G., Carosi, R., Carretero-Castrillo, M., Castro-Tirado, A. J., Ceribella, G., Chai, Y., Chilingarian, A., Cikota, S., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Amico, G., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Del Popolo, A., Delfino, M., Delgado, J., Delgado Mendez, C., Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espiñeira, E., Dominis Prester, D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Emery, G., Escudero, J., Fallah Ramazani, V., Fariña, L., Fattorini, A., Foffano, L., Font, L., Fruck, C., Fukami, S., Fukazawa, Y., García López, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giesbrecht Paiva, J. G., Giglietto, N., Giordano, F., Gliwny, P., Godinović, N., Grau, R., Green, D., Green, J. G., Hadasch, D., Hahn, A., Hassan, T., Heckmann, L., Herrera, J., Hrupec, D., Hütten, M., Imazawa, R., Inada, T., Iotov, R., Ishio, K., Jiménez Martínez, I., Jormanainen, J., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Linhoff, L., Lombardi, S., Longo, F., López-Coto, R., López-Moya, M., López-Oramas, A., Loporchio, S., Lorini, A., Lyard, E., Machado de Oliveira Fraga, B., Majumdar, P., Makariev, M., Maneva, G., Mang, N., Manganaro, M., Mangano, S., Mannheim, K., Mariotti, M., Martínez, M., Mas-Aguilar, A., Mazin, D., Menchiari, S., Mender, S., Mićanović, S., Miceli, D., Miener, T., Miranda, J. M., Mirzoyan, R., Molina, E., Mondal, H. A., Moralejo, A., Morcuende, D., Moreno, V., Nakamori, T., Nanci, C., Nava, L., Neustroev, V., Nievas Rosillo, M., Nigro, C., Nilsson, K., Nishijima, K., Njoh Ekoume, T., Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Okumura, A., Otero-Santos, J., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavletić, L., Persic, M., Pihet, M., Pirola, G., Podobnik, F., Prada Moroni, P. G., Prandini, E., Principe, G., Priyadarshi, C., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Saturni, F. G., Schleicher, B., Schmidt, K., Schmuckermaier, F., Schubert, J. L., Schweizer, T., Sitarek, J., Sliusar, V., Sobczynska, D., Spolon, A., Stamerra, A., Strišković, J., Strom, D., Strzys, M., Suda, Y., Surić, T., Tajima, H., Takahashi, M., Takeishi, R., Tavecchio, F., Temnikov, P., Terauchi, K., Terzić, T., Teshima, M., Tosti, L., Truzzi, S., Tutone, A., Ubach, S., van Scherpenberg, J., Vazquez Acosta, M., Ventura, S., Verguilov, V., Viale, I., Vigorito, C. F., Vitale, V., Vovk, I., Walter, R., Will, M., Wunderlich, C., Yamamoto, T., Zarić, D., Other, Groups, Cerruti, collaborations: M., Acosta-Pulido, J. A., Apolonio, G., Bachev, R., Baloković, M., Benítez, E., Björklund, I., Bozhilov, V., Brown, L. F., Bugg, A., Carbonell, W., Carnerero, M. I., Carosati, D., Casadio, C., Chamani, W., Chen, W. P., Chigladze, R. A., Damljanovic, G., Epps, K., Erkenov, A., Feige, M., Finke, J., Fuentes, A., Gazeas, K., Giroletti, M., Grishina, T. S., Gupta, A. C., Gurwell, M. A., Heidemann, E., Hiriart, D., Hou, W. J., Hovatta, T., Ibryamov, S., Joner, M. D., Jorstad, S. G., Kania, J., Kiehlmann, S., Kimeridze, G. N., Kopatskaya, E. N., Kopp, M., Korte, M., Kotas, B., Koyama, S., Kramer, J. A., Kunkel, L., Kurtanidze, S. O., Kurtanidze, O. M., Lähteenmäki, A., López, J. M., Larionov, V. M., Larionova, E. G., Larionova, L. V., Leto, C., Lorey, C., Mújica, R., Madejski, G. M., Marchili, N., Marscher, A. P., Minev, M., Modaressi, A., Morozova, D. A., Mufakharov, T., Myserlis, I., Nikiforova, A. A., Nikolashvili, M. G., Ovcharov, E., Perri, M., Raiteri, C. M., Readhead, A. C. S., Reimer, A., Reinhart, D., Righini, S., Rosenlehner, K., Sadun, A. C., Savchenko, S. S., Scherbantin, A., Schneider, L., Schoch, K., Seifert, D., Semkov, E., Sigua, L. A., Singh, C., Sola, P., Sotnikova, Y., Spencer, M., Steineke, R., Stojanovic, M., Strigachev, A., Tornikoski, M., Traianou, E., Tramacere, A., Troitskaya, Yu. V., Troitskiy, I. S., Trump, J. B., Tsai, A., Valcheva, A., Vasilyev, A. A., Verrecchia, F., Villata, M., Vince, O., Vrontaki, K., Weaver, Z. R., Zaharieva, E., Zottmann, N., Ministerio de Ciencia e Innovación (España), European Commission, Federal Ministry of Education and Research (Germany), Istituto Nazionale di Fisica Nucleare, Istituto Nazionale di Astrofisica, Swiss National Science Foundation, Department of Atomic Energy (India), Ministry of Education, Culture, Sports, Science and Technology (Japan), Ministry of Education and Science (Bulgaria), and Academy of Finland
Subjects: High Energy Astrophysical Phenomena (astro-ph.HE), BL Lacertae objects: individual (VER J0521+211 = RGB J0521.8+2112) – galaxies: active – galaxies: jets – gamma rays: galaxies – radiation mechanisms: non-thermal, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astronomy and Astrophysics, Active galactic nuclei, High energy astrophysics, Blazars, BL Lacertae objects, Relativistic jets, Gamma-rays, Non-thermal radiation sources, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics - Astrophysics of Galaxies, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), ddc:520, Física nuclear, Astrophysics - High Energy Astrophysical Phenomena
Abstract: Full list of authors: Adams, C. B.; Batista, P.; Benbow, W.; Brill, A.; Brose, R.; Buckley, J. H.; Capasso, M.; Christiansen, J. L.; Errando, M.; Feng, Q.; Finley, J. P.; Foote, G. M.; Fortson, L.; Furniss, A.; Gallagher, G.; Gent, A.; Giuri, C.; Hanlon, W. F.; Hanna, D.; Hassan, T.; Hervet, O.; Holder, J.; Hona, B.; Hughes, G.; Humensky, T. B.; Jin, W.; Kaaret, P.; Kertzman, M.; Kieda, D.; Kleiner, T. K.; Krennrich, F.; Kumar, S.; Lang, M. J.; Lundy, M.; Maier, G.; Millis, J.; Moriarty, P.; Mukherjee, R.; Nievas-Rosillo, M.; Ong, R. A.; Otte, A. N.; Patel, S.; Patel, S. R.; Pfrang, K.; Pohl, M.; Prado, R. R.; Pueschel, E.; Quinn, J.; Ragan, K.; Reynolds, P. T.; Ribeiro, D.; Roache, E.; Ryan, J. L.; Sadeh, I; Santander, M.; Sembroski, G. H.; Shang, R.; Stevenson, B.; Tucci, J., V; Vassiliev, V. V.; Wakely, S. P.; Weinstein, A.; Wells, R. M.; Williams, D. A.; Williamson, T. J.; Acciari, V. A.; Aniello, T.; Ansoldi, S.; Antonelli, L. A.; Engels, A. Arbet; Arcaro, C.; Artero, M.; Asano, K.; Baack, D.; Babic, A.; Baquero, A.; de Almeida, U. Barres; Barrio, J. A.; Batkovic, I; Becerra Gonzalez, J.; Bednarek, W.; Bernardini, E.; Bernardos, M.; Berti, A.; Besenrieder, J.; Bhattacharyya, W.; Bigongiari, C.; Biland, A.; Blanch, O.; Bokenkamp, H.; Bonnoli, G.; Bosnjak, Z.; Burelli, I; Busetto, G.; Carosi, R.; Ceribella, G.; Cerruti, M.; Chai, Y.; Chilingarian, A.; Cikota, S.; Colombo, E.; Contreras, J. L.; Cortina, J.; Covino, S.; D'Amico, G.; D'Elia, V; Da Vela, P.; Dazzi, F.; De Angelis, A.; De Lotto, B.; Del Popolo, A.; Delfino, M.; Delgado, J.; Delgado Mendez, C.; Depaoli, D.; Di Pierro, F.; Di Venere, L.; Do Souto Espineira, E.; Prester, D. Dominis; Donini, A.; Dorner, D.; Doro, M.; Elsaesser, D.; Ramazani, V. Fallah; Farina, L.; Fattorini, A.; Font, L.; Fruck, C.; Fukami, S.; Fukazawa, Y.; Garcia Lopez, R. J.; Garczarczyk, M.; Gasparyan, S.; Gaug, M.; Giglietto, N.; Giordano, F.; Gliwny, P.; Godinovic, N.; Green, J. G.; Green, D.; Hadasch, D.; Hahn, A.; Hassan, T.; Heckmann, L.; Herrera, J.; Hrupec, D.; Hutten, M.; Inada, T.; Iotov, R.; Ishio, K.; Iwamura, Y.; Jimenez Martinez, I; Jormanainen, J.; Jouvin, L.; Kerszberg, D.; Kobayashi, Y.; Kubo, H.; Kushida, J.; Lamastra, A.; Lelas, D.; Leone, F.; Lindfors, E.; Linhoff, L.; Lombardi, S.; Longo, F.; Lopez-Coto, R.; Lopez-Moya, M.; Lopez-Oramas, A.; Loporchio, S.; Lorini, A.; de Oliveira Fraga, B. Machado; Maggio, C.; Majumdar, P.; Makariev, M.; Maneva, G.; Manganaro, M.; Mannheim, K.; Mariotti, M.; Martinez, M.; Aguilar, A. Mas; Mazin, D.; Menchiari, S.; Mender, S.; Micanovic, S.; Miceli, D.; Miener, T.; Miranda, J. M.; Mirzoyan, R.; Molina, E.; Mondal, H. A.; Moralejo, A.; Morcuende, D.; Moreno, V; Nakamori, T.; Nanci, C.; Nava, L.; Neustroev, V; Nievas Rosillo, M.; Nigro, C.; Nilsson, K.; Nishijima, K.; Noda, K.; Nozaki, S.; Ohtani, Y.; Oka, T.; Otero-Santos, J.; Paiano, S.; Palatiello, M.; Paneque, D.; Paoletti, R.; Paredes, J. M.; Pavletic, L.; Penil, P.; Persic, M.; Pihet, M.; Moroni, P. G. Prada; Prandini, E.; Priyadarshi, C.; Puljak, I; Rhode, W.; Ribo, M.; Rico, J.; Righi, C.; Rugliancich, A.; Sahakyan, N.; Saito, T.; Sakurai, S.; Satalecka, K.; Saturni, F. G.; Schleicher, B.; Schmidt, K.; Schmuckermaier, F.; Schubert, J. L.; Schweizer, T.; Sitarek, J.; Snidaric, I; Sobczynska, D.; Spolon, A.; Stamerra, A.; Striskovic, J.; Strom, D.; Strzys, M.; Suda, Y.; Suric, T.; Takahashi, M.; Takeishi, R.; Tavecchio, F.; Temnikov, P.; Terzic, T.; Teshima, M.; Tosti, L.; Truzzi, S.; Tutone, A.; Ubach, S.; van Scherpenberg, J.; Vanzo, G.; Vazquez Acosta, M.; Ventura, S.; Verguilov, V.; Viale, I; Vigorito, C. F.; Vitale, V.; Vovk, I; Will, M.; Wunderlich, C.; Yamamoto, T.; Zaric, D.; VERITAS Collaboration; MAGIC Collaboration.--This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited., We report on a long-lasting, elevated gamma-ray flux state from VER J0521+211 observed by VERITAS, MAGIC, and Fermi-LAT in 2013 and 2014. The peak integral flux above 200 GeV measured with the nightly binned light curve is (8.8 ± 0.4) × 10−7 photons m−2 s−1, or ∼37% of the Crab Nebula flux. Multiwavelength observations from X-ray, UV, and optical instruments are also presented. A moderate correlation between the X-ray and TeV gamma-ray fluxes was observed, and the X-ray spectrum appeared harder when the flux was higher. Using the gamma-ray spectrum and four models of the extragalactic background light (EBL), a conservative 95% confidence upper limit on the redshift of the source was found to be z ≤ 0.31. Unlike the gamma-ray and X-ray bands, the optical flux did not increase significantly during the studied period compared to the archival low-state flux. The spectral variability from optical to X-ray bands suggests that the synchrotron peak of the spectral energy distribution (SED) may become broader during flaring states, which can be adequately described with a one-zone synchrotron self-Compton model varying the high-energy end of the underlying particle spectrum. The synchrotron peak frequency of the SED and the radio morphology of the jet from the MOJAVE program are consistent with the source being an intermediate-frequency-peaked BL Lac object. © 2022. The Author(s). Published by the American Astronomical Society., This research is supported by grants from the U.S. Department of Energy Office of Science, the U.S. National Science Foundation, and the Smithsonian Institution in the U.S.; by NSERC in Canada; and by the Helmholtz Association in Germany. This research used resources provided by the Open Science Grid, which is supported by the National Science Foundation and the U.S. Department of Energy's Office of Science, and resources of the National Energy Research Scientific Computing Center (NERSC), a U.S. Department of Energy Office of Science User Facility operated under contract No. DE-AC02-05CH11231. We acknowledge the excellent work of the technical support staff at the Fred Lawrence Whipple Observatory and at the collaborating institutions in the construction and operation of the instrument. The MAGIC Collaboration would like to thank the Instituto de Astrofísica de Canarias for the excellent working conditions at the Observatorio del Roque de los Muchachos in La Palma. The financial support of the German BMBF, MPG, and HGF; the Italian INFN and INAF; the Swiss National Fund SNF; the ERDF under the Spanish Ministerio de Ciencia e Innovación (MICINN) (PID2019-104114RB-C31, PID2019-104114RB-C32, PID2019-104114RB-C33, PID2019-105510GB-C31,PID2019-107847RB-C41, PID2019-107847RB-C42, PID2019-107847RB-C44, PID2019-107988GB-C22); the Indian Department of Atomic Energy; the Japanese ICRR, the University of Tokyo, JSPS, and MEXT; the Bulgarian Ministry of Education and Science, National RI Roadmap Project DO1-400/18.12.2020; and the Academy of Finland grant No. 320045 is gratefully acknowledged. This work was also supported by the Spanish Centro de Excelencia "Severo Ochoa" (SEV-2016-0588, SEV-2017-0709, CEX2019-000920-S), the Unidad de Excelencia "María de Maeztu" (CEX2019-000918-M, MDM-2015-0509-18-2), and the CERCA program of the Generalitat de Catalunya; by the Croatian Science Foundation (HrZZ) Project IP-2016-06-9782 and the University of Rijeka Project uniri-prirod-18-48; by the DFG Collaborative Research Centers SFB823/C4 and SFB876/C3; by the Polish National Research Centre grant UMO-2016/22/M/ST9/00382; and by the Brazilian MCTIC, CNPq, and FAPERJ. Q.F. was supported by NSF grant PHY-1806554 at Barnard College.
Published: 2022
Full Text: View/download PDF

11. Unveiling the complex correlation patterns in Mrk 421

Author: Arbet-Engels, A., Paneque, D., Heckmann, L., Acciari, V. A., Ansoldi, S., Antonelli, L. A., Artero, M., Asano, K., Baack, D., Babić, A., Baquero, A., Barres Almeida, U., Barrio, J. A., Batković, I., Becerra González, J., Bednarek, W., Bellizzi, L., Bernardini, E., Bernardos, M., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bökenkamp, H., Bonnoli, G., Bošnjak, Ž, Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colak, S. M., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Giacomo D'Amico, D Elia, V., Da Vela, P., Dazzi, F., Angelis, A., Lotto, B., Delfino, M., Delgado, J., Delgado Mendez, C., Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espiñeira, E., Dominis Prester, D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Fukazawa, Y., García López, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinović, N., Green, J. G., Green, D., Hadasch, D., Hahn, A., Herrera, J., Hoang, J., Hrupec, D., Hütten, M., Inada, T., Ishio, K., Iwamura, Y., Jiménez Martínez, I., Jormanainen, J., Jouvin, L., Karjalainen, M., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Linhoff, L., Lombardi, S., Longo, F., López-Coto, R., López-Moya, M., López-Oramas, A., Loporchio, S., Machado Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Mazin, D., Menchiari, S., Mender, S., Mićanović, S., Miceli, D., Miener, T., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Nakamori, T., Nava, L., Neustroev, V., Nigro, C., Nilsson, K., Nishijima, K., Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Paiano, S., Palatiello, M., Paoletti, R., Paredes, J. M., Pavletić, L., Peñil, P., Persic, M., Pihet, M., Prada Moroni, P. G., Prandini, E., Priyadarshi, C., Puljak, I., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Saturni, F. G., Schleicher, B., Schmidt, K., Schweizer, T., Sitarek, J., Šnidarić, I., Sobczynska, D., Spolon, A., Stamerra, A., Strišković, J., Strom, D., Strzys, M., Suda, Y., Surić, T., Takahashi, M., Takeishi, R., Tavecchio, F., Temnikov, P., Terzić, T., Teshima, M., Tosti, L., Truzzi, S., Tutone, A., Ubach, S., Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Ventura, S., Verguilov, V., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Wunderlich, C., Yamamoto, T., Zarić, D., Balbo, M., Bretz, T., Buss, J., Eisenberger, L., Hildebrand, D., Iotov, R., Kalenski, A., D Ammando, F., Horan, D., Lien, A. Y., Baloković, M., Madejski, G. M., Perri, M., Verrecchia, F., Leto, C., Lähteenmäki, A., Tornikoski, M., Ramakrishnan, V., Järvelä, E., Vera, R. J. C., Villata, M., Raiteri, C. M., Gupta, A. C., Pandey, A., Fuentes, A., Agudo, I., Casadio, C., Semkov, E., Ibryamov, S., Marchini, A., Bachev, R., Strigachev, A., Ovcharov, E., Bozhilov, V., Valcheva, A., Zaharieva, E., Damljanovic, G., Vince, O., Larionov, V. M., Borman, G. A., Grishina, T. S., Hagen-Thorn, V. A., Kopatskaya, E. N., Larionova, E. G., Larionova, L. V., Morozova, D. A., Nikiforova, A. A., Savchenko, S. S., Troitskiy, I. S., Troitskaya, Y. V., Vasilyev, A. A., Merkulova, O. A., Chen, W. P., Samal, M., Lin, H. C., Moody, J. W., Sadun, A. C., Jorstad, S. G., Marscher, A. P., Weaver, Z. R., Feige, M., Kania, J., Kopp, M., Kunkel, L., Reinhart, D., Scherbantin, A., Schneider, L., Lorey, C., Acosta-Pulido, J. A., Carnerero, M. I., Carosati, D., Kurtanidze, S. O., Kurtanidze, O. M., Nikolashvili, M. G., Chanishvili, R. G., Chigladze, R. A., Ivanidze, R. Z., Kimeridze, G. N., Sigua, L. A., Joner, M. D., Spencer, M., Giroletti, M., Marchili, N., Righini, S., and Rizzi, N.
Subjects: Physics, education.field_of_study, Astrophysics::High Energy Astrophysical Phenomena, Population, Flux, Sigma, Astrophysics, Synchrotron, Redshift, law.invention, law, MAGIC (telescope), education, Blazar, Flare
Abstract: The blazar Mrk421 (redshift z=0.031) is one of the brightest and closest BL Lac type objects, making it an ideal target to probe blazar physics. We report on an extensive multi-wavelength observing campaign in 2017, during which the intra-band correlation patterns show some disparity and complex behaviours. Observations from several instruments are used to achieve an optimal temporal coverage from radio to TeV energies. In particular, four multi-hour NuSTAR observations organised simultaneously with MAGIC allow to obtain a precise measurement of the falling segments of the two spectral components. A detailed investigation of the very-high-energy (VHE; >100 GeV) versus X-ray flux correlation is performed, by binning the data into several sub-energy bands. A positively correlated variability is observed, but the correlation characteristics change substantially across the various bands probed. Furthermore, during the simultaneous MAGIC and NuSTAR observations a clear change of the Compton dominance is detected without a simultaneous change in the synchrotron regime, indicating "orphan gamma-ray activity". We also investigate an intriguing bright flare at VHE without a substantial flux increase in the X-rays. Within a leptonic scenario, this behaviour is best explained by the appearance of a second population of highly-energetic electrons spanning a narrow range of energies. Finally, our multi-wavelength correlation study also reveals an anti-correlation between the UV/optical and X-ray bands at a significance level above 3 sigma.
Published: 2022

12. Life-time prediction for rocks under static compressive and tensile loads: a new simulation approach

Author: Konietzky, H., Heftenberger, A., and Feige, M.
Published: 2009
Full Text: View/download PDF

13. Simulation von Gruppenarbeit in der Montage

Author: Seliger, G., Wang, Y., Feige, M., and Publica
Subjects: Prozeßorganisation, Fließmontage, Arbeitsorganisation, Gruppenarbeit
Abstract: Die flexible Automatisierung in der Montage, einhergebend mit der Erweiterung herkömmlicher Organisationsformen, hat sich erst vereinzelt durchgesetzt. Die Einführung von Gruppenarbeit zählt zu den wichtigsten organisatorischen Maßnahmen. Simulation kann die Planung der erforderlichen Arbeitsabläufe unterstützen.
Published: 1993

14. Technikgestaltung in der flexibel automatisierten Serienmontage

Author: Barbey, J., Feige, M., and Publica
Subjects: Materialfluss, Serienmontage, Umfeldgestaltung, Organisationsgestaltung, flexibel automatisierte Serienmontage, Kapazitätsteilung, Montage-Evaluierung, Montagestation, Arbeitsplatzgestaltung, Montage, Montagesystem, Arbeitsstrukturierung, Fördermittel, Ergonomie, Technikgestaltung, flexible Serienmontage, Entkoppelung
Abstract: Ein großes Potential zur Senkung von Herstellkosten liegt in der Automatisierung von Montagevorrichtungen. Dabei setzt sich zunehmend die Erkenntnis durch, daß Automatisierungsmaßnahmen nur unter Berücksichtigung der geamtbetrieblichen Zusammenhänge von Technik, Organisation und Personal wirtschaftlich durchführbar sind. Positive Erfahrungen liegen aus Unternehmen vor, die organisatorische und personelle Voraussetzungen abgeleitet und vorbereitend umgesetzt haben. Humanisierungsmaßnahmen können die Attraktivität von Industriearbeit durch Verbesserung der individuellen Arbeitsbedingungen bei gleichzeitiger Produktivitätssteigerung erhöhen. Es werden Empfehlungen für die Gestaltung von Materialflußsystemen, Montagesystemen und -stationen gegeben. Dazu werden Ergebnisse von Modellvorhaben und Fallstudien zusammengefaßt, die im Rahmen eines Verbundprojekts mit der Bezeichnung "Evaluierung von betrieblichen Modellvorhaben zur menschengerechten Anwendung neuer Technologien in der Serienmonta ge" durchgeführt werden.
Published: 1992

15. Simulationsunterstützte Planung von Gruppenarbeit in der Montage

Author: Seliger, G., primary, Feige, M., additional, and Wang, Y., additional
Published: 1993
Full Text: View/download PDF

16. Neuheiten der Montage- und Handhabungstechnik

Author: Feige, M., primary
Published: 1990
Full Text: View/download PDF

17. Investigation of the correlation patterns and the Compton dominance variability of Mrk 421 in 2017

Author: Acciari, V. A., Ansoldi, S., Antonelli, L. A., Engels, A. Arbet, Artero, M., Asano, K., Babi��, A., Baquero, A., de Almeida, U. Barres, Barrio, J. A., Batkovi��, I., Gonz��lez, J. Becerra, Bednarek, W., Bellizzi, L., Bernardini, E., Bernardos, M., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Blanch, O., Bo��njak, Z., Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colak, S. M., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Amico, G., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Mendez, C. Delgado, Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espi��eira, E., Prester, D. Dominis, Donini, A., Doro, M., Ramazani, V. Fallah, Fattorini, A., Ferrara, G., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., L��pez, R. J. Garc��a, Garczarczyk, Markus, Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinovi��, N., Green, J. G., Green, D., Hadasch, D., Hahn, A., Heckmann, L., Herrera, J., Hoang, J., Hrupec, D., H��tten, M., Inada, T., Inoue, S., Ishio, K., Iwamura, Y., Jim��nez, I., Jormanainen, J., Jouvin, L., Kajiwara, Y., Karjalainen, M., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., L��pez-Coto, R., L��pez-Moya, M., L��pez-Oramas, A., Loporchio, S., de Oliveira Fraga, B. Machado, Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Maraschi, L., Mariotti, M., Mart��nez, M., Mazin, D., Menchiari, S., Mender, S., Mi��anovi��, S., Miceli, D., Miener, T., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Neustroev, V., Nigro, C., Nilsson, K., Nishijima, K., Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavleti��, L., Pe��il, P., Perennes, C., Persic, M., Moroni, P. G. Prada, Prandini, E., Priyadarshi, C., Puljak, I., Rib��, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Saturni, F. G., Schmidt, K., Schweizer, T., Sitarek, J., ��nidari��, I., Sobczynska, D., Spolon, A., Stamerra, A., Strom, D., Strzys, M., Suda, Y., Suri��, T., Takahashi, M., Tavecchio, F., Temnikov, P., Terzi��, T., Teshima, M., Tosti, L., Truzzi, S., Tutone, A., Ubach, S., van Scherpenberg, J., Vanzo, G., Acosta, M. Vazquez, Ventura, S., Verguilov, V., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Wunderlich, C., Zari��, D., Baack, D., Balbo, M., Biederbeck, N., Biland, A., Bretz, T., Buss, J., Dorner, D., Eisenberger, L., Elsaesser, D., Hildebrand, D., Iotov, R., Mannheim, K., Neise, D., Noethe, M., Paravac, A., Rhode, W., Schleicher, B., Sliusar, V., Walter, R., D'Ammando, F., Horan, D., Lien, A. Y., Balokovi��, M., Madejski, G. M., Perri, M., Verrecchia, F., Leto, C., L��hteenm��ki, A., Tornikoski, M., Ramakrishnan, V., J��rvel��, E., Vera, R. J. C., Chamani, W., Villata, M., Raiteri, C. M., Gupta, A. C., Pandey, A., Fuentes, A., Agudo, I., Casadio, C., Semkov, E., Ibryamov, S., Marchini, A., Bachev, R., Strigachev, A., Ovcharov, E., Bozhilov, V., Valcheva, A., Zaharieva, E., Damljanovic, G., Vince, O., Larionov, V. M., Borman, G. A., Grishina, T. S., Hagen-Thorn, V. A., Kopatskaya, E. N., Larionova, E. G., Larionova, L. V., Morozova, D. A., Nikiforova, A. A., Savchenko, S. S., Troitskiy, I. S., Troitskaya, Y. V., Vasilyev, A. A., Merkulova, O. A., Chen, W. P., Samal, M., Lin, H. C., Moody, J. W., Sadun, A. C., Jorstad, S. G., Marscher, A. P., Weaver, Z. R., Feige, M., Kania, J., Kopp, M., Kunkel, L., Reinhart, D., Scherbantin, A., Schneider, L., Lorey, C., Acosta-Pulido, J. A., Carnerero, M. I., Carosati, D., Kurtanidze, S. O., Kurtanidze, O. M., Nikolashvili, M. G., Chanishvili, R. G., Chigladze, R. A., Ivanidze, R. Z., Kimeridze, G. N., Sigua, L. A., Joner, M. D., Spencer, M., Giroletti, M., Marchili, N., Righini, S., Rizzi, N., and Bonnoli, G.
Subjects: electron, galaxies: active, flux: correlation, GeV, radiation mechanisms: non-thermal, 7. Clean energy, MAGIC, GLAST, blazar, gamma ray: VHE, ultraviolet, optical, spectral, TeV, BL Lacertae objects: individual: Mrk 421, X-ray: flux, model: leptonic, Lorentz
Abstract: Astronomy and astrophysics 655, A89 (2021). doi:10.1051/0004-6361/202141004, Aims. We present a detailed characterisation and theoretical interpretation of the broadband emission of the paradigmatic TeV blazar Mrk 421, with a special focus on the multi-band flux correlations.Methods. The dataset has been collected through an extensive multi-wavelength campaign organised between 2016 December and 2017 June. The instruments involved are MAGIC, FACT, Fermi-LAT, Swift, GASP-WEBT, OVRO, Medicina, and Mets��hovi. Additionally, four deep exposures (several hours long) with simultaneous MAGIC and NuSTAR observations allowed a precise measurement of the falling segments of the two spectral components.Results. The very-high-energy (VHE; E > 100 GeV) gamma rays and X-rays are positively correlated at zero time lag, but the strength and characteristics of the correlation change substantially across the various energy bands probed. The VHE versus X-ray fluxes follow different patterns, partly due to substantial changes in the Compton dominance for a few days without a simultaneous increase in the X-ray flux (i.e., orphan gamma-ray activity). Studying the broadband spectral energy distribution (SED) during the days including NuSTAR observations, we show that these changes can be explained within a one-zone leptonic model with a blob that increases its size over time. The peak frequency of the synchrotron bump varies by two orders of magnitude throughout the campaign. Our multi-band correlation study also hints at an anti-correlation between UV-optical and X-ray at a significance higher than 3��. A VHE flare observed on MJD 57788 (2017 February 4) shows gamma-ray variability on multi-hour timescales, with a factor ten increase in the TeV flux but only a moderate increase in the keV flux. The related broadband SED is better described by a two-zone leptonic scenario rather than by a one-zone scenario. We find that the flare can be produced by the appearance of a compact second blob populated by high energetic electrons spanning a narrow range of Lorentz factors, from ��$_{min}$=2��10$^4$ to ��$_{max}$=6��10$^5$.Key words: galaxies: active / BL Lacertae objects: individual: Mrk 421 / radiation mechanisms: non-thermal�� Light curves and spectral energy distributions data are only available at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/cat/J/A+A/655/A89�� Corresponding authors: A. Arbet Engels and D. Paneque; e-mail: contact.magic@mpp.mpg.de.�� Also member of the MAGIC Collaboration.�� Also member of the FACT Collaboration., Published by EDP Sciences, Les Ulis

18. Determination of the two major metabolites of ebselen in human plasma by high-performance liquid chromatography

Author: Terlinden, R., primary, Feige, M., additional, and Römer, A., additional
Published: 1988
Full Text: View/download PDF

19. VERY HIGH ENERGY γ -RAYS FROM THE UNIVERSE’S MIDDLE AGE: DETECTION OF THE z = 0.940 BLAZAR PKS 1441+25 WITH MAGIC

Author: M. Pesce Rollins, Lluis Font, Francesco Longo, Abelardo Moralejo, I. Snidaric, Thomas Bretz, M. Feige, E. Moretti, Mosè Mariotti, A.-K. Overkemping, M. Makariev, D. Wolfert, E. Lorenz, Max Ludwig Ahnen, S. Haarto, P. Giammaria, T. Steinbring, S. Maldera, F. de Palma, D. Dominis Prester, Nicola Omodei, Marcel Strzys, P. Haeusner, R. Clavero, W. Bednarek, Fabrizio Tavecchio, R. Reinthal, R. Zanin, Elina Lindfors, D. Nakajima, Daniela Dorner, Adrian Biland, P. G. Prada Moroni, R. A. Cameron, M. Gaug, M. Caragiulo, Johan Bregeon, Saverio Lombardi, Kyoshi Nishijima, Arka Chatterjee, D. Fidalgo, U. Barres de Almeida, Damir Lelas, J. Kushida, Daniel Mazin, Igor V. Moskalenko, Olaf Reimer, Julie McEnery, Anne Lähteenmäki, Hiromitsu Takahashi, Julian Sitarek, A. López Oramas, J. Herrera, Wolfgang Rhode, J. Rico, J. Klamt, Dorota Sobczyńska, Jose Luis Contreras, Hiroyasu Tajima, X. Paredes Fortuny, Koji Noda, J. Li, A. Niedzwiecki, Masahiro Teshima, P. Bruel, E. Orlando, Yusuke Konno, T. Toyama, E. Recillas, V. Fallah Ramazani, Elisa Bernardini, K. S. Wood, Carmelo Sgrò, Riccardo Rando, Nikola Godinovic, T. Ohsugi, Eleonora Troja, Juan Cortina, D. J. Thompson, F. Di Pierro, Benito Marcote, P. Fusco, E. Colombo, Stefano Ansoldi, Ievgen Vovk, Oscar Blanch, N. Zottmann, E. Hays, Talvikki Hovatta, Riccardo Paoletti, M. Razzano, Ivica Puljak, E. Nuss, David Paneque, C. Delgado Mendez, Filippo D'Ammando, F. Piron, Pierre Colin, B. De Lotto, Stefano Covino, A. De Angelis, Luigi Pacciani, A. Treves, Vitaly Neustroev, T. Schweizer, M. Kuss, R. Bonino, J. Palacio, R. Mirzoyan, I. A. Grenier, P. Temnikov, Stefano Ciprini, E. de Oña Wilhelmi, Nestor Mirabal, P. Da Vela, L. Carrasco, Marcello Giroletti, L. O. Takalo, D. Guberman, M. I. Martínez, J. M. Paredes, E. Cavazzuti, M. Mayer, Juri Poutanen, S. Rainò, Antonio Stamerra, F. Borracci, Tsunefumi Mizuno, Y. Hanabata, A. González Muñoz, G. Maneva, Marina Manganaro, P. Spinelli, S. Bonnefoy, Kari Nilsson, T. A. Porter, Gloria Spandre, J. Hose, P. Antoranz, Tomoki Saito, D. Tescaro, D. Galindo, U. Menzel, E. Prandini, M. Will, G. Chiaro, Marco Ajello, J. B. Thayer, Merja Tornikoski, F. Loparco, Markus Garczarczyk, Francesco Giordano, B. Banerjee, Sabrina Einecke, D. Elsaesser, J. W. Hewitt, R. Desiante, D. Garrido Terrats, A. Fernández Barral, Diego F. Torres, James Chiang, H. Takami, M. Palatiello, S. Buson, Alessandro Carosi, J. Rodriguez Garcia, P. Lubrano, Mislav Baloković, A. Carraminana, Konstancja Satalecka, A. Sillanpää, L. Di Venere, Dario Gasparrini, Michele Doro, Roger Blandford, Vassil Verguilov, Roopesh Ojha, L. Maraschi, Francesco Dazzi, Ana Babić, Gareth Hughes, F. Spada, Julia Thaele, Tomislav Terzić, A. Porras, M. E. Monzani, A. Morselli, Jose Miguel Miranda, G. A. Caliandro, A. Reimer, W. Idec, A. Hahn, E. Carmona, Stefan Larsson, J. Kania, M. Hayashida, Wu M. H., Steven N. Shore, C. Lorey, Marc Ribó, P. Bangale, E. J. Siskind, Hidetoshi Kubo, Dario Hrupec, M. A. Lopez, G. Bonnoli, F. Gargano, K. Mallot, R. J. García López, R. Lopez Coto, Massimo Persic, V. H. Chavushyan, Liang Li, Guido Barbiellini, J. León Tavares, Pratik Majumdar, M. V. Fonseca, K. Kodani, Reiko Orito, Aaron Dominguez, Juan Abel Barrio, Luca Baldini, J. E. Ward, Sylvain Guiriec, Mn Mazziotta, Christian Fruck, J. S. Perkins, Nicola Giglietto, B. Biasuzzi, M. N. Lovellette, P. A. Caraveo, J. Becerra González, Elisabetta Bissaldi, G. Pivato, Andrei Berdyugin, T. Jogler, Ronaldo Bellazzini, C. Schultz, Louis Antonelli, K. Frantzen, Denis Bastieri, S. Paiano, Karl Mannheim, A. La Barbera, D. Eisenacher Glawion, M. Nievas Rosillo, Universitat de Barcelona, Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire Univers et Particules de Montpellier (LUPM), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), ITA, USA, GBR, FRA, DEU, ESP, AFG, ALB, DZA, AND, AGO, BGR, BFA, BDI, KHM, CMR, CAN, CPV, CS, TCD, CYM, COD, CHL, TWN, CYP, VAT, COL, COM, COG, PRK, KOR, CIV, DOM, CCK, CRI, HRV, CUB, DNK, DMA, ECU, EGY, SLV, ARE, CHN, ERI, AIA, EST, ETH, FJI, PHL, FIN, GAB, GMB, GAZA, ZAF, GEO, COK, GHA, JAM, JPN, GIB, DJI, JOR, GRC, REU, GRD, GRL, GLP, FRO, GUM, GTM, GIN, GNB, GNQ, GUI, ROU, GUY, GUF, HTI, HND, FLK, HKG, IND, IDN, IRN, MNP, RWA, MHL, MUS, UMI, SLB, TCA, VIR, ATA, VGB, ISR, KAZ, RUS, KGZ, KIR, SCG, KWT, LAO, LSO, LVA, ATG, LBN, LBR, ESH, LBY, LIE, LTU, LUX, MAC, MKD, MDG, MWI, ANT, MDV, AUS, MYS, MLI, MLT, MAR, MTQ, MRT, MYT, MEX, MDA, SAU, IRQ, MCO, MNG, MSR, MOZ, MMR, NAM, NRU, NPL, NIC, NER, KNA, ARG, NGA, NIU, NOR, NCL, NZL, OMN, NLD, PAK, PLW, SPM, PAN, ARM, PNG, PRY, PER, PCN, PYF, POL, PRI, PRT, VCT, QAT, CZE, ABW, CAF, ASM, WSM, SMR, LCA, SHN, STP, SEN, IRL, AUT, SYC, SLE, SGP, SYR, SVK, SVN, SOM, LKA, ISL, FSM, AZE, SGS, SDN, SUR, SJM, SWE, CHE, SWZ, TJK, BVT, TZA, IOT, BHS, ATF, PSE, THA, TLS, TGO, TKL, TON, MAN, TTO, TUN, TUR, BHR, TKM, TUV, UKR, UGA, HUN, URY, CXR, UZB, VUT, VEN, VNM, BGD, WLF, YEM, ZMB, ZWE, BRB, HMD, BEL, BLZ, BEN, BMU, BTN, BLR, BOL, BIH, BWA, BRA, NFK, BRN, Ahnen, M. L., Ansoldi, S., Antonelli, L. A., Antoranz, P., Babic, A., Banerjee, B., Bangale, P., De Almeida, U. Barre, Barrio, J. A., Bednarek, W., Bernardini, E., Biasuzzi, B., Biland, A., Blanch, O., Bonnefoy, S., Bonnoli, G., Borracci, F., Bretz, T., Carmona, E., Carosi, A., Chatterjee, A., Clavero, R., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., De Oña Wilhelmi, E., Mendez, C. Delgado, Di Pierro, F., Prester, D. Domini, Dorner, D., Doro, M., Einecke, S., Glawion, D. Eisenacher, Elsaesser, D., Fernández Barral, A., Fidalgo, D., Fonseca, M. V., Font, L., Frantzen, K., Fruck, C., Galindo, D., López, R. J. García, Garczarczyk, M., Terrats, D. Garrido, Gaug, M., Giammaria, P., Godinović, N., Muñoz, A. González, Guberman, D., Hahn, A., Hanabata, Y., Hayashida, M., Herrera, J., Hose, J., Hrupec, D., Hughes, G., Idec, W., Kodani, K., Konno, Y., Kubo, H., Kushida, J., La Barbera, A., Lelas, D., Lindfors, E., Lombardi, S., López, M., López Coto, R., López Oramas, A., Lorenz, E., Majumdar, P., Makariev, M., Mallot, K., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Marcote, B., Mariotti, M., Martínez, M., Mazin, D., Menzel, U., Miranda, J. M., Mirzoyan, R., Moralejo, A., Moretti, E., Nakajima, D., Neustroev, V., Niedzwiecki, A., Rosillo, M. Nieva, Nilsson, K., Nishijima, K., Noda, K., Orito, R., Overkemping, A., Paiano, S., Palacio, J., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Paredes Fortuny, X., Persic, M., Poutanen, J., Moroni, P. G. Prada, Prandini, E., Puljak, I., Rhode, W., Ribó, M., Rico, J., Garcia, J. Rodriguez, Saito, T., Satalecka, K., Schultz, C., Schweizer, T., Shore, S. N., Sillanpää, A., Sitarek, J., Snidaric, I., Sobczynska, D., Stamerra, A., Steinbring, T., Strzys, M., Takalo, L., Takami, H., Tavecchio, F., Temnikov, P., Terzić, T., Tescaro, D., Teshima, M., Thaele, J., Torres, D. F., Toyama, T., Treves, A., Verguilov, V., Vovk, I., Ward, J. E., Will, M., Wu, M. H., Zanin, R., Ajello, M., Baldini, L., Barbiellini, G., Bastieri, D., González, J. Becerra, Bellazzini, R., Bissaldi, E., Blandford, R. D., Bonino, R., Bregeon, J., Bruel, P., Buson, S., Caliandro, G. A., Cameron, R. A., Caragiulo, M., Caraveo, P. A., Cavazzuti, E., Chiang, J., Chiaro, G., Ciprini, S., D'Ammando, F., De Palma, F., Desiante, R., Di Venere, L., Domínguez, A., Fusco, P., Gargano, F., Gasparrini, D., Giglietto, N., Giordano, F., Giroletti, M., Grenier, I. A., Guiriec, S., Hays, E., Hewitt, J. W., Jogler, T., Kuss, M., Larsson, S., Li, J., Li, L., Longo, Francesco, Loparco, F., Lovellette, M. N., Lubrano, P., Maldera, S., Mayer, M., Mazziotta, M. N., Mcenery, J. E., Mirabal, N., Mizuno, T., Monzani, M. E., Morselli, A., Moskalenko, I. V., Nuss, E., Ojha, R., Ohsugi, T., Omodei, N., Orlando, E., Perkins, J. S., Pesce Rollins, M., Piron, F., Pivato, G., Porter, T. A., Raino, S., Rando, R., Razzano, M., Reimer, A., Reimer, O., Sgro, C., Siskind, E. J., Spada, F., Spandre, G., Spinelli, P., Tajima, H., Takahashi, H., Thayer, J. B., Thompson, D. J., Troja, E., Wood, K. S., Balokovic, M., Berdyugin, A., Carraminana, A., Carrasco, L., Chavushyan, V., Ramazani, V. Fallah, Feige, M., Haarto, S., Haeusner, P., Hovatta, T., Kania, J., Klamt, J., Lähteenmäki, A., Leon Tavares, J., Lorey, C., Pacciani, L., Porras, A., Recillas, E., Reinthal, R., Tornikoski, M., Wolfert, D., Zottmann, N., Ahnen ML, Ansoldi S, Antonelli LA, Antoranz P, Babic A, Banerjee B, Bangale P, De Almeida UB, Barrio JA, Bednarek W, Bernardini E, Biasuzzi B, Biland A, Blanch O, Bonnefoy S, Bonnoli G, Borracci F, Bretz T, Carmona E, Carosi A, Chatterjee A, Clavero R, Colin P, Colombo E, Contreras JL, Cortina J, Covino S, Da Vela P, Dazzi F, De Angelis A, De Lotto B, Wilhelmi ED, Mendez CD, Di Pierro F, Prester DD, Dorner D, Doro M, Einecke S, Glawion DE, Elsaesser D, Fernandez-Barral A, Fidalgo D, Fonseca MV, Font L, Frantzen K, Fruck C, Galindo D, Lopez RJG, Garczarczyk M, Terrats DG, Gaug M, Giammaria P, Godinovic N, Munoz AG, Guberman D, Hahn A, Hanabata Y, Hayashida M, Herrera J, Hose J, Hrupec D, Hughes G, Idec W, Kodani K, Konno Y, Kubo H, Kushida J, La Barbera A, Lelas D, Lindfors E, Lombardi S, Lopez M, Lopez-Coto R, Lopez-Oramas A, Lorenz E, Majumdar P, Makariev M, Mallot K, Maneva G, Manganaro M, Mannheim K, Maraschi L, Marcote B, Mariotti M, Martinez M, Mazin D, Menzel U, Miranda JM, Mirzoyan R, Moralejo A, Moretti E, Nakajima D, Neustroev V, Niedzwiecki A, Rosillo M, Nilsson K, Nishijima K, Noda K, Orito R, Overkemping A, Paiano S, Palacio J, Palatiello M, Paneque D, Paoletti R, Paredes JM, Paredes-Fortuny X, Persic M, Poutanen J, Moroni PGP, Prandini E, Puljak I, Rhode W, Ribo M, Rico J, Garcia JR, Saito T, Satalecka K, Schultz C, Schweizer T, Shore SN, Sillanpaa A, Sitarek J, Snidaric I, Sobczynska D, Stamerra A, Steinbring T, Strzys M, Takalo L, Takami H, Tavecchio F, Temnikov P, Terzic T, Tescaro D, Teshima M, Thaele J, Torres DF, Toyama T, Treves A, Verguilov V, Vovk I, Ward JE, Will M, Wu MH, Zanin R, Ajello M, Baldini L, Barbiellini G, Bastieri D, Gonzalez JB, Bellazzini R, Bissaldi E, Blandford RD, Bonino R, Bregeon J, Bruel P, Buson S, Caliandro GA, Cameron RA, Caragiulo M, Caraveo PA, Cavazzuti E, Chiang J, Chiaro G, Ciprini S, DAmmando F, de Palma F, Desiante R, Di Venere L, Dominguez A, Fusco P, Gargano F, Gasparrini D, Giglietto N, Giordano F, Giroletti M, Grenier IA, Guiriec S, Hays E, Hewitt JW, Jogler T, Kuss M, Larsson S, Li J, Li L, Longo F, Loparco F, Lovellette MN, Lubrano P, Maldera S, Mayer M, Mazziotta MN, McEnery JE, Mirabal N, Mizuno T, Monzani ME, Morselli A, Moskalenko IV, Nuss E, Ojha R, Ohsugi T, Omodei N, Orlando E, Perkins JS, Pesce-Rollins M, Piron F, Pivato G, Porter TA, Raino S, Rando R, Razzano M, Reimer A, Reimer O, Sgro C, Siskind EJ, Spada F, Spandre G, Spinelli P, Tajima H, Takahashi H, Thayer JB, Thompson DJ, Troja E, Wood KS, Balokovic M, Berdyugin A, Carraminana A, Carrasco L, Chavushyan V, Ramazani VF, Feige M, Haarto S, Haeusner P, Hovatta T, Kania J, Klamt J, Lahteenmaki A, Leon-Tavares J, Lorey C, Pacciani L, Porras A, Recillas E, Reinthal R, Tornikoski M, Wolfert D, and Zottmann N
Subjects: individual (PKS 1441+25) [quasars], cosmic background radiation, Astrophysics, 7. Clean energy, Raigs gamma, Jets (Astrofísica), galaxies: active, galaxies: jets, gamma rays: galaxies, quasars: individual (PKS 1441+25), MAGIC (telescope), Space and Planetary Science, Astronomy and Astrophysics, ComputingMilieux_MISCELLANEOUS, astro-ph.HE, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, Extragalactic background light, active [galaxies], Spectral energy distribution, Electrónica, Física nuclear, Electricidad, Astrophysics - High Energy Astrophysical Phenomena, astro-ph.GA, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], cosmic background radiation – galaxies: active – galaxies: jets – gamma rays: galaxies – quasars: individual (PKS 1441+25), galaxie [gamma rays], Blazar, Quasars, Quàsars, Gamma rays, Quasar, Astrophysics - Astrophysics of Galaxies, Redshift, Galaxy, Astrophysical jets, jet [galaxies], 13. Climate action, Astrophysics of Galaxies (astro-ph.GA), Galàxies actives, Active galaxies, ddc:520, Fermi Gamma-ray Space Telescope
Abstract: The flat-spectrum radio quasar PKS 1441+25 at a redshift of z = 0.940 is detected between 40 and 250 GeV with a significance of 25.5 {\sigma} using the MAGIC telescopes. Together with the gravitationally lensed blazar QSO B0218+357 (z = 0.944), PKS 1441+25 is the most distant very high energy (VHE) blazar detected to date. The observations were triggered by an outburst in 2015 April seen at GeV energies with the Large Area Telescope on board Fermi. Multi-wavelength observations suggest a subdivision of the high state into two distinct flux states. In the band covered by MAGIC, the variability time scale is estimated to be 6.4 +/- 1.9 days. Modeling the broadband spectral energy distribution with an external Compton model, the location of the emitting region is understood as originating in the jet outside the broad line region (BLR) during the period of high activity, while being partially within the BLR during the period of low (typical) activity. The observed VHE spectrum during the highest activity is used to probe the extragalactic background light at an unprecedented distance scale for ground-based gamma-ray astronomy., Comment: Corresponding Authors: J. Becerra (josefa.becerra@nasa.gov), M. Nievas Rosillo (mnievas@ucm.es), M. Manganaro (manganaro@iac.es), F. Tavecchio (fabrizio.tavecchio@brera.inaf.it) Published in The Astrophysical Journal Letters (ApJL), 2015ApJ...815L..23A, DOI: 10.1088/2041-8205/815/2/L23
Published: 2015

20. Investigation of the correlation patterns and the Compton dominance variability of Mrk 421 in 2017

Author: Katsuaki Asano, I. Jiménez, A. Fuentes, C. M. Raiteri, D. Dominis Prester, E. Molina, E. Colombo, Y. V. Troitskaya, Nikola Godinovic, Sidika Merve Colak, Jenni Jormanainen, Yuki Iwamura, Alessandra Lamastra, Lab Saha, Antoniya Valcheva, Sunay Ibryamov, Elena G. Larionova, B. De Lotto, Evgeni Ovcharov, D. Zarić, Kazuma Ishio, David A. Green, M. Villata, D. Horan, Givi N. Kimeridze, Alexander Hahn, S. Nozaki, M. Perri, Michael D. Joner, D. Neise, S. Loporchio, R. J. García López, Marcello Giroletti, Victor A. Acciari, V. Fallah Ramazani, Tomohiko Oka, Daniela Dorner, Narek Sahakyan, J. Kushida, M. Kopp, Lorenzo Bellizzi, Noah Biederbeck, Joseph Moody, M. Gaug, L. Schneider, A. López-Oramas, Daniel Morcuende, N. Rizzi, Jose Luis Contreras, G. Vanzo, Rodolfo Carosi, L. Maraschi, Andrés Baquero, M. I. Carnerero, R. Iotov, Mosè Mariotti, A. Paravac, John Hoang, Ashwani Pandey, Z. R. Weaver, Francesco Longo, F. D'Ammando, S. Paiano, Elina Lindfors, Moritz Hütten, J. Herrera, Koji Noda, Abelardo Moralejo, Laura Eisenberger, E. Moretti, Julian Sitarek, Marcos López-Moya, Wlodek Bednarek, L. Di Venere, Ashot Chilingarian, U. Barres de Almeida, Elisa Bernardini, I. Agudo, M. Feige, R. Z. Ivanidze, O. A. Merkulova, D. Depaoli, M. Spencer, Massimo Persic, J. van Scherpenberg, Pratik Majumdar, L. Kunkel, K. Nishijima, Stefano Ansoldi, Juan Cortina, Kai Phillip Schmidt, A. Berti, Riccardo Paoletti, Saverio Lombardi, Daniel Mazin, M. V. Fonseca, Damir Lelas, R. J. C. Vera, Sanae Inoue, Giacomo D'Amico, Dominik Baack, C. Perennes, A. A. Nikiforova, Yating Chai, Stefan Cikota, G. M. Madejski, A. Arbet Engels, Daniel Kerszberg, Manuel Artero, E. Do Souto Espiñeira, Tomislav Terzić, J. Becerra González, Martin Makariev, R. Mirzoyan, Yoshiki Ohtani, G. A. Borman, Pawel Gliwny, Jose Miguel Miranda, A. De Angelis, Vitaly Neustroev, Wara Chamani, Oscar Blanch, T. S. Grishina, Martin Will, M. Vazquez Acosta, Nicola Giglietto, L. V. Larionova, Lea Heckmann, Francesco Gabriele Saturni, Jorge Otero-Santos, R. A. Chigladze, M. Balbo, N. Marchili, D. Hadasch, P. G. Prada Moroni, A. A. Vasilyev, M. G. Nikolashvili, Jordi Delgado, V. Ramakrishnan, Christian Fruck, G. Busetto, Victoria Moreno, Luca Tosti, A. Rugliancich, C. Nigro, Marina Manganaro, Valeri M. Larionov, M. Balokovic, Manuel Delfino, A. Strigachev, J. M. Paredes, Manash R. Samal, Stefano Covino, I. Vovk, H. C. Lin, Ž. Bošnjak, Stefano Menchiari, Rumen Bachev, Marc Ribó, Dorota Sobczyńska, Carolin Wunderlich, Bernd Schleicher, M. Minev, Antonio Stamerra, Maria-Isabel Bernardos, I. S. Troitskiy, Merja Tornikoski, E. N. Kopatskaya, Shunsuke Sakurai, Camilla Maggio, Chiara Righi, F. Verrecchia, P. Temnikov, S. G. Jorstad, T. Schweizer, Hidetoshi Kubo, Lluis Font, A. Y. Lien, Toshiaki Inada, A. Scherbantin, Lorand A. Sigua, G. Maneva, Stefano Truzzi, B. Machado de Oliveira Fraga, V. Bozhilov, M. Palatiello, Alessandro Marchini, Chaitanya Priyadarshi, Alessia Spolon, Léa Jouvin, Konstancja Satalecka, Tomoki Saito, Giovanni Ceribella, Michele Doro, S. O. Kurtanidze, Carlo Vigorito, Pablo Peñil, D. Strom, Giacomo Bonnoli, Adrian Biland, Ana Babić, Alicia Fattorini, D. Hildebrand, Satoshi Fukami, G. Ferrara, Y. Kajiwara, Matteo Cerruti, P. Da Vela, Vassil Verguilov, Lovro Pavletić, C. Delgado Mendez, Emilia Järvelä, S. Mićanović, Sergey S. Savchenko, Ivica Puljak, M. Noethe, Simone Mender, Francesco Dazzi, V. Vitale, Manuela Mallamaci, Ivana Batković, F. Leone, M. I. Martínez, J. Rico, Alan P. Marscher, C. Lorey, S. Ventura, Tjark Miener, Anne Lähteenmäki, David Paneque, Masahiro Teshima, Jarred Gershon Green, Wrijupan Bhattacharyya, Kari Nilsson, R. Walter, M. Strzys, D. Reinhart, E. Zaharieva, Wen Ping Chen, Vitalii Sliusar, Jürgen Besenrieder, Francesco Giordano, Antonio Tutone, Thomas Bretz, J. Buss, Alok C. Gupta, Simona Righini, O. M. Kurtanidze, Ciro Bigongiari, O. Vince, D. Elsaesser, C. Leto, M. Garczarczyk, Sargis Gasparyan, J. Kania, Dario Hrupec, R. López-Coto, Wolfgang Rhode, I. Snidaric, D. A. Morozova, Vladimir A. Hagen-Thorn, Mitsunari Takahashi, J. A. Acosta-Pulido, E. Prandini, Marie Karjalainen, D. Miceli, Goran Damljanović, Evgeni Semkov, Alice Donini, L. A. Antonelli, J. A. Barrio, Y. Suda, D. Carosati, V. D'Elia, Fabrizio Tavecchio, A. C. Sadun, Tihomir Surić, C. Casadio, Karl Mannheim, Santiago Ubach, Y. Kobayashi, F. Di Pierro, European Commission, European Research Council, Ministerio de Ciencia e Innovación (España), Generalitat de Catalunya, Federal Ministry of Education and Research (Germany), German Research Foundation, Swiss National Science Foundation, Croatian Science Foundation, Ministry of Education, Science and Technological Development (Serbia), Bulgarian National Science Fund, National Aeronautics and Space Administration (US), Acciari, V. A., Ansoldi, S., Antonelli, L. A., Arbet Engels, A., Artero, M., Asano, K., Babi??, A., Baquero, A., Barres de Almeida, U., Barrio, J. A., Batkovi??, I., Becerra Gonz??lez, J., Bednarek, W., Bellizzi, L., Bernardini, E., Bernardos, M., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Blanch, O., Bo??njak, ??., Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colak, S. M., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D???amico, G., D???elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Delgado Mendez, C., Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espi??eira, E., Dominis Prester, D., Donini, A., Doro, M., Fallah Ramazani, V., Fattorini, A., Ferrara, G., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Garc??a L??pez, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinovi??, N., Green, J. G., Green, D., Hadasch, D., Hahn, A., Heckmann, L., Herrera, J., Hoang, J., Hrupec, D., H??tten, M., Inada, T., Inoue, S., Ishio, K., Iwamura, Y., Jim??nez, I., Jormanainen, J., Jouvin, L., Kajiwara, Y., Karjalainen, M., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., L??pez-Coto, R., L??pez-Moya, M., L??pez-Oramas, A., Loporchio, S., Machado de Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Maraschi, L., Mariotti, M., Mart??nez, M., Mazin, D., Menchiari, S., Mender, S., Mi??anovi??, S., Miceli, D., Miener, T., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Neustroev, V., Nigro, C., Nilsson, K., Nishijima, K., Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavleti??, L., Pe??il, P., Perennes, C., Persic, M., Prada Moroni, P. G., Prandini, E., Priyadarshi, C., Puljak, I., Rib??, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Saturni, F. G., Schmidt, K., Schweizer, T., Sitarek, J., nidari??, I., Sobczynska, D., Spolon, A., Stamerra, A., Strom, D., Strzys, M., Suda, Y., Suri??, T., Takahashi, M., Tavecchio, F., Temnikov, P., Terzi??, T., Teshima, M., Tosti, L., Truzzi, S., Tutone, A., Ubach, S., van Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Ventura, S., Verguilov, V., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Wunderlich, C., Zari??, D., Baack, D., Balbo, M., Biederbeck, N., Biland, A., Bretz, T., Buss, J., Dorner, D., Eisenberger, L., Elsaesser, D., Hildebrand, D., Iotov, R., Mannheim, K., Neise, D., Noethe, M., Paravac, A., Rhode, W., Schleicher, B., Sliusar, V., Walter, R., D???ammando, F., Horan, D., Lien, A. Y., Balokovi??, M., Madejski, G. M., Perri, M., Verrecchia, F., Leto, C., L??hteenm??ki, A., Tornikoski, M., Ramakrishnan, V., J??rvel??, E., Vera, R. J. C., Chamani, W., Villata, M., Raiteri, C. M., Gupta, A. C., Pandey, A., Fuentes, A., Agudo, I., Casadio, C., Semkov, E., Ibryamov, S., Marchini, A., Bachev, R., Strigachev, A., Ovcharov, E., Bozhilov, V., Valcheva, A., Zaharieva, E., Damljanovic, G., Vince, O., Larionov, V. M., Borman, G. A., Grishina, T. S., Hagen-Thorn, V. A., Kopatskaya, E. N., Larionova, E. G., Larionova, L. V., Morozova, D. A., Nikiforova, A. A., Savchenko, S. S., Troitskiy, I. S., Troitskaya, Y. V., Vasilyev, A. A., Merkulova, O. A., Chen, W. P., Samal, M., Lin, H. C., Moody, J. W., Sadun, A. C., Jorstad, S. G., Marscher, A. P., Weaver, Z. R., Feige, M., Kania, J., Kopp, M., Kunkel, L., Reinhart, D., Scherbantin, A., Schneider, L., Lorey, C., Acosta-Pulido, J. A., Carnerero, M. I., Carosati, D., Kurtanidze, S. O., Kurtanidze, O. M., Nikolashvili, M. G., Chigladze, R. A., Ivanidze, R. Z., Kimeridze, G. N., Sigua, L. A., Joner, M. D., Spencer, M., Giroletti, M., Marchili, N., Righini, S., Rizzi, N., Bonnoli, G., Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), MAGIC, FACT, Department of Electronics and Nanoengineering, Aalto-yliopisto, and Aalto University
Subjects: electron, PARTICLE-ACCELERATION, ELECTRON ACCELERATION, Radiation mechanisms: non-thermal, RAY, VHE [gamma ray], galaxies: active, BL Lacertae objects: individual: Mrk 421, radiation mechanisms: non-thermal, Electron, Astrophysics, GeV, 01 natural sciences, 7. Clean energy, LARGE-AREA TELESCOPE, law.invention, OBSERVATIONS, law, ultraviolet, optical, MAGIC (telescope), correlation [flux], 010303 astronomy & astrophysics, X-ray: flux, model: leptonic, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), BL-LACERTAE, individual: Mrk 421 [BL Lacertae objects], flux [X-ray], Gamma ray, flux: correlation, Galaxies: active, non-thermal [radiation mechanisms], Synchrotron, SWIFT OBSERVATIONS, active [galaxies], Spectral energy distribution, Física nuclear, Astrophysics - High Energy Astrophysical Phenomena, Lorentz, Flare, LOG-PARABOLIC SPECTRA, ACTIVE GALACTIC NUCLEI, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, radiation, mechanisms: non-thermal, LIGHT CURVES, X-RAY, MULTIWAVELENGTH, GLAST, leptonic [model], blazar, 0103 physical sciences, TeV, Blazar, 010308 nuclear & particles physics, Astronomy and Astrophysics, MAGIC, gamma ray: VHE, Space and Planetary Science, ddc:520, spectral, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Fermi Gamma-ray Space Telescope
Abstract: Full list of authors: Acciari, V. A.; Ansoldi, S.; Antonelli, L. A.; Arbet Engels, A.; Artero, M.; Asano, K.; Babić, A.; Baquero, A.; Barres de Almeida, U.; Barrio, J. A.; Batković, I.; Becerra González, J.; Bednarek, W.; Bellizzi, L.; Bernardini, E.; Bernardos, M.; Berti, A.; Besenrieder, J.; Bhattacharyya, W.; Bigongiari, C.; Blanch, O.; Bošnjak, Ž.; Busetto, G.; Carosi, R.; Ceribella, G.; Cerruti, M.; Chai, Y.; Chilingarian, A.; Cikota, S.; Colak, S. M.; Colombo, E.; Contreras, J. L.; Cortina, J.; Covino, S.; D'Amico, G.; D'Elia, V.; da Vela, P.; Dazzi, F.; de Angelis, A.; de Lotto, B.; Delfino, M.; Delgado, J.; Delgado Mendez, C.; Depaoli, D.; di Pierro, F.; di Venere, L.; Do Souto Espiñeira, E.; Dominis Prester, D.; Donini, A.; Doro, M.; Fallah Ramazani, V.; Fattorini, A.; Ferrara, G.; Fonseca, M. V.; Font, L.; Fruck, C.; Fukami, S.; García López, R. J.; Garczarczyk, M.; Gasparyan, S.; Gaug, M.; Giglietto, N.; Giordano, F.; Gliwny, P.; Godinović, N.; Green, J. G.; Green, D.; Hadasch, D.; Hahn, A.; Heckmann, L.; Herrera, J.; Hoang, J.; Hrupec, D.; Hütten, M.; Inada, T.; Inoue, S.; Ishio, K.; Iwamura, Y.; Jiménez, I.; Jormanainen, J.; Jouvin, L.; Kajiwara, Y.; Karjalainen, M.; Kerszberg, D.; Kobayashi, Y.; Kubo, H.; Kushida, J.; Lamastra, A.; Lelas, D.; Leone, F.; Lindfors, E.; Lombardi, S.; Longo, F.; López-Coto, R.; López-Moya, M.; López-Oramas, A.; Loporchio, S.; Machado de Oliveira Fraga, B.; Maggio, C.; Majumdar, P.; Makariev, M.; Mallamaci, M.; Maneva, G.; Manganaro, M.; Maraschi, L.; Mariotti, M.; Martínez, M.; Mazin, D.; Menchiari, S.; Mender, S.; Mićanović, S.; Miceli, D.; Miener, T.; Minev, M.; Miranda, J. M.; Mirzoyan, R.; Molina, E.; Moralejo, A.; Morcuende, D.; Moreno, V.; Moretti, E.; Neustroev, V.; Nigro, C.; Nilsson, K.; Nishijima, K.; Noda, K.; Nozaki, S.; Ohtani, Y.; Oka, T.; Otero-Santos, J.; Paiano, S.; Palatiello, M.; Paneque, D.; Paoletti, R.; Paredes, J. M.; Pavletić, L.; Peñil, P.; Perennes, C.; Persic, M.; Prada Moroni, P. G.; Prandini, E.; Priyadarshi, C.; Puljak, I.; Ribó, M.; Rico, J.; Righi, C.; Rugliancich, A.; Saha, L.; Sahakyan, N.; Saito, T.; Sakurai, S.; Satalecka, K.; Saturni, F. G.; Schmidt, K.; Schweizer, T.; Sitarek, J.; Šnidarić, I.; Sobczynska, D.; Spolon, A.; Stamerra, A.; Strom, D.; Strzys, M.; Suda, Y.; Surić, T.; Takahashi, M.; Tavecchio, F.; Temnikov, P.; Terzić, T.; Teshima, M.; Tosti, L.; Truzzi, S.; Tutone, A.; Ubach, S.; van Scherpenberg, J.; Vanzo, G.; Vazquez Acosta, M.; Ventura, S.; Verguilov, V.; Vigorito, C. F.; Vitale, V.; Vovk, I.; Will, M.; Wunderlich, C.; Zarić, D.; Baack, D.; Balbo, M.; Biederbeck, N.; Biland, A.; Bretz, T.; Buss, J.; Dorner, D.; Eisenberger, L.; Elsaesser, D.; Hildebrand, D.; Iotov, R.; Mannheim, K.; Neise, D.; Noethe, M.; Paravac, A.; Rhode, W.; Schleicher, B.; Sliusar, V.; Walter, R.; D'Ammando, F.; Horan, D.; Lien, A. Y.; Baloković, M.; Madejski, G. M.; Perri, M.; Verrecchia, F.; Leto, C.; Lähteenmäki, A.; Tornikoski, M.; Ramakrishnan, V.; Järvelä, E.; Vera, R. J. C.; Chamani, W.; Villata, M.; Raiteri, C. M.; Gupta, A. C.; Pandey, A.; Fuentes, A.; Agudo, I.; Casadio, C.; Semkov, E.; Ibryamov, S.; Marchini, A.; Bachev, R.; Strigachev, A.; Ovcharov, E.; Bozhilov, V.; Valcheva, A.; Zaharieva, E.; Damljanovic, G.; Vince, O.; Larionov, V. M.; Borman, G. A.; Grishina, T. S.; Hagen-Thorn, V. A.; Kopatskaya, E. N.; Larionova, E. G.; Larionova, L. V.; Morozova, D. A.; Nikiforova, A. A.; Savchenko, S. S.; Troitskiy, I. S.; Troitskaya, Y. V.; Vasilyev, A. A.; Merkulova, O. A.; Chen, W. P; Samal, M.; Lin, H. C.; Moody, J. W.; Sadun, A. C.; Jorstad, S. G.; Marscher, A. P.; Weaver, Z. R.; Feige, M.; Kania, J.; Kopp, M.; Kunkel, L.; Reinhart, D.; Scherbantin, A.; Schneider, L.; Lorey, C.; Acosta-Pulido, J. A.; Carnerero, M. I.; Carosati, D.; Kurtanidze, S. O.; Kurtanidze, O. M.; Nikolashvili, M. G.; Chigladze, R. A.; Ivanidze, R. Z.; Kimeridze, G. N.; Sigua, L. A.; Joner, M. D.; Spencer, M.; Giroletti, M.; Marchili, N.; Righini, S.; Rizzi, N.; Bonnoli, G.; MAGIC Collaboration; Fact Collaboration.-- This is an Open Access article, published by EDP Sciences, under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited., Aims. We present a detailed characterisation and theoretical interpretation of the broadband emission of the paradigmatic TeV blazar Mrk 421, with a special focus on the multi-band flux correlations. Methods. The dataset has been collected through an extensive multi-wavelength campaign organised between 2016 December and 2017 June. The instruments involved are MAGIC, FACT, Fermi-LAT, Swift, GASP-WEBT, OVRO, Medicina, and Metsahovi. Additionally, four deep exposures (several hours long) with simultaneous MAGIC and NuSTAR observations allowed a precise measurement of the falling segments of the two spectral components. Results. The very-high-energy (VHE; E 100 GeV) gamma rays and X-rays are positively correlated at zero time lag, but the strength and characteristics of the correlation change substantially across the various energy bands probed. The VHE versus X-ray fluxes follow dierent patterns, partly due to substantial changes in the Compton dominance for a few days without a simultaneous increase in the X-ray flux (i.e., orphan gamma-ray activity). Studying the broadband spectral energy distribution (SED) during the days including NuSTAR observations, we show that these changes can be explained within a one-zone leptonic model with a blob that increases its size over time. The peak frequency of the synchrotron bump varies by two orders of magnitude throughout the campaign. Our multi-band correlation study also hints at an anti-correlation between UV-optical and X-ray at a significance higher than 3. A VHE flare observed on MJD 57788 (2017 February 4) shows gamma-ray variability on multi-hour timescales, with a factor ten increase in the TeV flux but only a moderate increase in the keV flux. The related broadband SED is better described by a two-zone leptonic scenario rather than by a one-zone scenario.We find that the flare can be produced by the appearance of a compact second blob populated by high energetic electrons spanning a narrow range of Lorentz factors, from 0 min = 2104 to 0 max = 6105. © 2021 Georg Thieme Verlag. All rights reserved., The MAGIC Collaboration would like to thank the Instituto de Astrofísica de Canarias for the excellent working conditions at the Observatorio del Roque de los Muchachos in La Palma. The financial support of the German BMBF, MPG and HGF; the Italian INFN and INAF; the Swiss National Fund SNF; the ERDF under the Spanish Ministerio de Ciencia e Innovación (MICINN) (FPA2017-87859-P, FPA2017-85668-P, FPA2017-82729-C6-5-R, FPA2017-90566-REDC, PID2019-104114RB-C31, PID2019-104114RB-C32, PID2019-105510GB-C31,PID2019-107847RB-C41, PID2019-107847RB-C42, PID2019-107847RB-C44, PID2019-107988GB-C22); the Indian Department of Atomic Energy; the Japanese ICRR, the University of Tokyo, JSPS, and MEXT; the Bulgarian Ministry of Education and Science, National RI Roadmap Project DO1-268/16.12.2019 and the Academy of Finland grant nr. 320045 is gratefully acknowledged. This work was also supported by the Spanish Centro de Excelencia “Severo Ochoa” SEV-2016-0588, SEV-2017-0709 and CEX2019-000920-S, and “María de Maeztu” CEX2019-000918-M, the Unidad de Excelencia “María de Maeztu” MDM-2015-0509-18-2 and the “la Caixa” Foundation (fellowship LCF/BQ/PI18/11630012) and by the CERCA program of the Generalitat de Catalunya; by the Croatian Science Foundation (HrZZ) Project IP-2016-06-9782 and the University of Rijeka Project 13.12.1.3.02; by the DFG Collaborative Research Centers SFB823/C4 and SFB876/C3; the Polish National Research Centre grant UMO-2016/22/M/ST9/00382; and by the Brazilian MCTIC, CNPq and FAPERJ. The important contributions from ETH Zurich grants ETH-10.08-2 and ETH-27.12-1 as well as the funding by the Swiss SNF and the German BMBF (Verbundforschung Astro- und Astroteilchenphysik) and HAP (Helmoltz Alliance for Astroparticle Physics) are gratefully acknowledged. Part of this work is supported by Deutsche Forschungsgemeinschaft (DFG) within the Collaborative Research Center SFB 876 “Providing Information by Resource-Constrained Analysis”, project C3. We are thankful for the very valuable contributions from E. Lorenz, D. Renker and G. Viertel during the early phase of the project. We thank the Instituto de Astrofísica de Canarias for allowing us to operate the telescope at the Observatorio del Roque de los Muchachos in La Palma, the Max-Planck-Institut für Physik for providing us with the mount of the former HEGRA CT3 telescope, and the MAGIC collaboration for their support. The Fermi LAT Collaboration acknowledges generous ongoing support from a number of agencies and institutes that have supported both the development and the operation of the LAT as well as scientific data analysis. These include the National Aeronautics and Space Administration and the Department of Energy in the United States, the Commissariat à l’Energie Atomique and the Centre National de la Recherche Scientifique/Institut National de Physique Nucléaire et de Physique des Particules in France, the Agenzia Spaziale Italiana and the Istituto Nazionale di Fisica Nucleare in Italy, the Ministry of Education, Culture, Sports, Science and Technology (MEXT), High Energy Accelerator Research Organization (KEK) and Japan Aerospace Exploration Agency (JAXA) in Japan, and the K. A. Wallenberg Foundation, the Swedish Research Council and the Swedish National Space Board in Sweden. Additional support for science analysis during the operations phase is gratefully acknowledged from the Istituto Nazionale di Astrofisica in Italy and the Centre National d’Études Spatiales in France. This work performed in part under DOE Contract DE-AC02-76SF00515. This work made use of data from the NuSTAR mission, a project led by the California Institute of Technology, managed by the Jet Propulsion Laboratory, and funded by the National Aeronautics and Space Administration. We thank the NuSTAR Operations, Software, and Calibration teams for support with the execution and analysis of these observations. This research has made use of the NuSTAR Data Analysis Software (NuSTARDAS) jointly developed by the ASI Science Data Center (ASDC; Italy) and the California Institute of Technology (USA). This research has also made use of the XRT Data Analysis Software (XRTDAS) developed under the responsibility of the ASI Science Data Center (ASDC), Italy. A.A.E and D.P acknowledge support from the Deutsche Forschungs gemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy – EXC-2094 – 390783311. M. B. acknowledges support from the YCAA Prize Postdoctoral Fellowship and from the Black Hole Initiative at Harvard University, which is funded in part by the Gordon and Betty Moore Foundation (grant GBMF8273) and in part by the John Templeton Foundation. This publication makes use of data obtained at the Metsähovi Radio Observatory, operated by Aalto University in Finland. This research has made use of data from the OVRO 40-m monitoring program (Richards et al. 2011) which is supported in part by NASA grants NNX08AW31G, NNX11A043G, and NNX14AQ89G and NSF grants AST-0808050 and AST-1109911. I.A. acknowledges financial support from the Spanish “Ministerio de Ciencia e Innovación” (MCINN) through the “Center of Excellence Severo Ochoa” award for the Instituto de Astrofísica de Andalucía-CSIC (SEV-2017-0709). Acquisition and reduction of the MAPCAT data was supported in part by MICINN through grants AYA2016-80889-P and PID2019-107847RB-C44. The MAPCAT observations were carried out at the German-Spanish Calar Alto Observatory, which is jointly operated by Junta de Andalucía and Consejo Superior de Investigaciones Científicas. C.C. acknowledges support from the European Research Council (ERC) under the European Union Horizon 2020 research and innovation program under the grant agreement No 771282. This research was partially supported by the Bulgarian National Science Fund of the Ministry of Education and Science under grants KP-06-H28/3 (2018), KP-06-H38/4 (2019) and KP-06-KITAJ/2 (2020). We acknowledge support by Bulgarian National Science Fund under grant DN18-10/2017 and National RI Roadmap Projects DO1-277/16.12.2019 and DO1-268/16.12.2019 of the Ministry of Education and Science of the Republic of Bulgaria. This research was supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia (contract No 451-03-68/2020-14/200002). G.D. acknowledges observing grant support from the Institute of Astronomy and Rozhen NAO BAS through the bilateral joint research project “Gaia Celestial Reference Frame (CRF) and fast variable astronomical objects” (2020–2022, head – G. Damljanovic). The BU group was supported in part by NASA Fermi guest investigator program grants 80NSSC19K1505 and 80NSSC20K1566. This study was based in part on observations conducted using the 1.8 m Perkins Telescope Observatory (PTO) in Arizona, which is owned and operated by Boston University. This article is partly based on observations made with the LCOGT Telescopes, one of whose nodes is located at the Observatorios de Canarias del IAC on the island of Tenerife in the Observatorio del Teide. This article is also based partly on data obtained with the STELLA robotic telescopes in Tenerife, an AIP facility jointly operated by AIP and IAC. The Abastumani team acknowledges financial support by the Shota Rustaveli National Science Foundation under contract FR-19-6174. Based on observations with the Medicina telescope operated by INAF – Istituto di Radioastronomia.
Published: 2021

21. Transient High Salt Intake Promotes T-Cell-Mediated Hypertensive Vascular Injury.

Author: Yakoub M, Rahman M, Kleimann P, Hoffe J, Feige M, Bouvain P, Alter C, Kluczny JI, Reidel S, Nederlof R, Hering L, Argov D, Arifaj D, Kantauskaite M, Meister J, Kleinewietfeld M, Rump LC, Jantsch J, Flögel U, Müller DN, Temme S, and Stegbauer J
Abstract: Background: Dietary high salt (HS) intake has a strong impact on cardiovascular diseases. Here, we investigated the link between HS-aggravated immune responses and the development of hypertensive vascular disease., Methods: ApolipoproteinE-deficient mice were transiently treated with HS (1% NaCl) via drinking water for 2 weeks, followed by a washout period, and subsequent Ang II (angiotensin II) infusion (1000 ng/kg per min for 10 days) to induce abdominal aortic aneurysms/dissections and inflammation., Results: While transient HS intake alone triggered nonpathologic infiltration of activated T cells into the aorta, subsequent Ang II infusion increased mortality and the incidence of abdominal aortic aneurysms/dissections and atherosclerosis compared with hypertensive control mice. There were no differences in blood pressure between both groups. In transient HS-treated hypertensive mice, the aortic injury was associated with increased inflammation, accumulation of neutrophils, monocytes, CD69 + CD4 + T cells, as well as CD4 + and CD8 + memory T cells. Mechanistically, transient HS intake increased expression levels of aortic RORγt as well as splenic CD4 + T H 17 and CD8 + T C 1 T cells in Ang II-treated mice. Isolated aortas of untreated mice were incubated with supernatants of T H 17, T H 1, or T C 1 cells polarized in vitro under HS or normal conditions which revealed that secreted factors of HS-differentiated T H 17 and T C 1 cells, but not T H 1 cells accelerated endothelial dysfunction., Conclusions: Our data suggest that transient HS intake induces a subclinical T-cell-mediated aortic immune response, which is enhanced by Ang II. We propose a 2-hit model, in which HS acts as a predisposing factor to enhance hypertension-induced T H 17 and T C 1 polarization and aortic disease.
Published: 2024
Full Text: View/download PDF

22. Rational combinatorial targeting by adapter CAR-T-cells (AdCAR-T) prevents antigen escape in acute myeloid leukemia.

Author: Atar D, Ruoff L, Mast AS, Krost S, Moustafa-Oglou M, Scheuermann S, Kristmann B, Feige M, Canak A, Wolsing K, Schlager L, Schilbach K, Zekri L, Ebinger M, Nixdorf D, Subklewe M, Schulte J, Lengerke C, Jeremias I, Werchau N, Mittelstaet J, Lang P, Handgretinger R, Schlegel P, and Seitz CM
Subjects: Humans, Animals, Mice, Child, Xenograft Model Antitumor Assays, Antigens, Neoplasm immunology, T-Lymphocytes immunology, T-Lymphocytes metabolism, Leukemia, Myeloid, Acute immunology, Leukemia, Myeloid, Acute therapy, Leukemia, Myeloid, Acute pathology, Immunotherapy, Adoptive methods, Receptors, Chimeric Antigen immunology, Receptors, Chimeric Antigen metabolism
Abstract: Targeting AML by chimeric antigen receptor T-cells (CAR-T) is challenging due to the promiscuous expression of AML-associated antigens in healthy hematopoiesis and high degree of inter- and intratumoral heterogeneity. Here, we present single-cell expression data of AML-associated antigens in 30 primary pediatric AML samples. We identified CD33, CD38, CD371, IL1RAP and CD123 as the most frequently expressed. Notably, high variability was observed not only across the different patient samples but also among leukemic cells of the same patient suggesting the necessity of multiplexed targeting approaches. To address this need, we utilized our modular Adapter CAR (AdCAR) platform, enabling precise qualitative and quantitative control over CAR-T-cell function. We show highly efficient and target-specific activity for newly generated adapter molecules (AMs) against CD33, CD38, CD123, CD135 and CD371, both in vitro and in vivo. We reveal that inherent intratumoral heterogeneity in antigen expression translates into antigen escape and therapy failure to monotargeted CAR-T therapy. Further, we demonstrate in PDX models that rational combinatorial targeting by AdCAR-T-cells can cure heterogenic disease. In conclusion, we elucidate the clinical relevance of heterogeneity in antigen expression in pediatric AML and present a novel concept for precision immunotherapy by combinatorial targeting utilizing the AdCAR platform., (© 2024. The Author(s).)
Published: 2024
Full Text: View/download PDF

23. Dementia-Friendly Hospital-The Perspective of Professional Dementia Experts.

Author: Manietta C, Purwins D, Pinkert C, Fink L, Rommerskirch-Manietta M, Feige M, Knecht C, and Roes M
Abstract: Aim: To investigate the professional dementia experts' understanding of a dementia-friendly hospital to identify its characteristics., Design: We used a qualitative design embedded in a case study. A total of 16 semi-structured expert interviews were conducted with 17 professional dementia experts. Using inductive content analysis, the interviews were analysed in a participatory manner involving a group of researchers and dementia experts., Results: We identified six characteristics of dementia-friendly hospitals: Proud to be dementia-friendly-That's what we want; Seeing the human being-Taking care of everyone; Having everyone on board-It's a collective task; Being professional-It takes more than being nice and kind; Rethinking the 'running' system-We have to change, not them; and Being part of the community-Thinking beyond the hospital., Conclusion: The concept of a dementia-friendly hospital seems complex and requires a rethinking of the traditional hospital. For a conceptualisation, the involvement of people with dementia and their relatives is important to gain a comprehensive understanding., Implications for the Profession and Patient Care: A dementia-friendly hospital is characterised by professional care that comprises a safe, familiar and supportive environment, is prepared but also flexible, has everyone on board, and sees the human being. To become dementia-friendly, individual interventions such as training courses can be a starting point. However, an overall concept is required that also includes components that contribute to successful implementation and a welcoming culture of people with dementia., Impact: Our findings on the perspective of professional dementia experts contribute to the conceptualisation of dementia-friendly hospitals., Reporting Method: We reported our study according to the COREQ checklist., Patient and Public Contribution: The investigation of the perspective of professional dementia experts is one part of a larger study. In this overall DEMfriendlyHospital study, we interviewed professional dementia experts, people with dementia and their relatives and also involved them in a participatory manner in various stages of the research process., (© 2024 The Author(s). Journal of Clinical Nursing published by John Wiley & Sons Ltd.)
Published: 2024
Full Text: View/download PDF

24. Precise in vivo RNA base editing with a wobble-enhanced circular CLUSTER guide RNA.

Author: Reautschnig P, Fruhner C, Wahn N, Wiegand CP, Kragness S, Yung JF, Hofacker DT, Fisk J, Eidelman M, Waffenschmidt N, Feige M, Pfeiffer LS, Schulz AE, Füll Y, Levanon EY, Mandel G, and Stafforst T
Abstract: Recruiting the endogenous editing enzyme adenosine deaminase acting on RNA (ADAR) with tailored guide RNAs for adenosine-to-inosine (A-to-I) RNA base editing is promising for safely manipulating genetic information at the RNA level. However, the precision and efficiency of editing are often compromised by bystander off-target editing. Here, we find that in 5'-UAN triplets, which dominate bystander editing, G•U wobble base pairs effectively mitigate off-target events while maintaining high on-target efficiency. This strategy is universally applicable to existing A-to-I RNA base-editing systems and complements other suppression methods such as G•A mismatches and uridine (U) depletion. Combining wobble base pairing with a circularized format of the CLUSTER approach achieves highly precise and efficient editing (up to 87%) of a disease-relevant mutation in the Mecp2 transcript in cell culture. Virus-mediated delivery of the guide RNA alone realizes functional MeCP2 protein restoration in the central nervous system of a murine Rett syndrome model with editing yields of up to 19% and excellent bystander control in vivo., (© 2024. The Author(s).)
Published: 2024
Full Text: View/download PDF

25. Application and challenges of TCR and BCR sequencing to investigate T- and B-cell clonality in elastase-induced experimental murine abdominal aortic aneurysm.

Author: Elster C, Ommer-Bläsius M, Lang A, Vajen T, Pfeiler S, Feige M, Yau Pang T, Böttenberg M, Verheyen S, Lê Quý K, Chernigovskaya M, Kelm M, Winkels H, Schmidt SV, Greiff V, and Gerdes N
Abstract: Background: An abdominal aortic aneurysm (AAA) is a life-threatening cardiovascular disease. Although its pathogenesis is still poorly understood, recent evidence suggests that AAA displays autoimmune disease characteristics. Particularly, T cells responding to AAA-related antigens in the aortic wall may contribute to an initial immune response. Single-cell RNA (scRNA) T cell receptor (TCR) and B cell receptor (BCR) sequencing is a powerful tool for investigating clonality. However, difficulties such as limited numbers of isolated cells must be considered during implementation and data analysis, making biological interpretation challenging. Here, we perform a representative single-cell immune repertoire analysis in experimental murine AAA and show a reliable bioinformatic processing pipeline highlighting opportunities and limitations of this approach., Methods: We performed scRNA TCR and BCR sequencing of isolated lymphocytes from the infrarenal aorta of male C57BL/6J mice 3, 7, 14, and 28 days after AAA induction via elastase perfusion of the aorta. Sham-operated mice at days 3 and 28 and non-operated mice served as controls., Results: Comparison of complementarity-determining region (CDR3) length distribution of 179 B cells and 796 T cells revealed neither differences between AAA and control nor between the disease stages. We found no clonal expansion of B cells in AAA. For T cells, we identified several clones in 11 of 16 AAA samples and one of eight control samples. Immune receptor repertoire comparison indicated that only a few clones were shared between the individual AAA samples. The most frequently used V-genes in the TCR beta chain in AAA were TRBV3, TRBV19, and the splicing variant TRBV12-2 + TRBV13-2., Conclusion: We found no clonal expansion of B cells but evidence for clonal expansion of T cells in elastase-induced AAA in mice. Our findings imply that a more precise characterization of TCR and BCR distribution requires a more extensive number of lymphocytes to prevent undersampling and potentially detect rare clones. Thus, further experiments are necessary to confirm our findings. In summary, this paper examines TCR and BCR sequencing results, identifies limitations and pitfalls, and offers guidance for future studies., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (© 2023 Elster, Ommer-Bläsius, Lang, Vajen, Pfeiler, Feige, Yau Pang, Böttenberg, Verheyen, Lê Quý, Chernigovskaya, Kelm, Winkels, Schmidt, Greiff and Gerdes.)
Published: 2023
Full Text: View/download PDF

26. Contextualizing the results of an integrative review on the characteristics of dementia-friendly hospitals: a workshop with professional dementia experts.

Author: Manietta C, Purwins D, Reinhard A, Feige M, Knecht C, Alpers B, and Roes M
Subjects: Humans, Germany epidemiology, Hospitals, Delivery of Health Care, Dementia diagnosis, Dementia epidemiology, Dementia therapy
Abstract: Background: To become a dementia-friendly hospital (DFH) is increasingly being discussed in health care practice, research, politics and society. In our previous integrative review, we identified six characteristics of DFHs. To thoroughly discuss and contextualize these characteristics in relation to hospitals in Germany, we involved professional dementia experts in our review process., Methods: At the end of our review process, we involved professional dementia experts at the 'contributing' level of the ACTIVE framework to discuss and reflect on the six DFH characteristics we identified. We conducted a group process in the form of a one-day workshop. The workshop consisted of four steps: 1. presentation of review results (input), 2. modification of DFH characteristics and rating of their relevance in smaller working groups, 3. discussion of group results in plenary and 4. questionnaire for prioritization and rating of feasibility. The data were analyzed in MAXQDA using content analysis and descriptive statistics., Results: A total of 16 professional dementia experts working in hospitals participated in the workshop. All the previously identified characteristics of a DFH were rated as relevant or very relevant for patients with dementia, their relatives and health care professionals from the professional dementia experts' perspective. They made a few modifications of the six characteristics at the level of subcategories, aspects, and descriptions. The feasibility of the characteristics in hospitals was critically discussed regarding resources, hospital structures and processes, the role of nurses, and the current care situation of people with dementia in hospitals. More than half of the subcategories of the characteristics were considered very difficult or difficult to implement by most professional dementia experts., Conclusion: The involvement of professional dementia experts helped us contextualize our review findings within the German hospital setting. These results highlight the need to consider resources, funding options, influencing factors, and the current situation and culture of care provided by hospitals before implementing DFH characteristics. Beside the involvement of professional dementia experts and various health care professionals, the involvement of other stakeholders, such as people with dementia and their relatives, is necessary in future research for the development of a DFH., (© 2023. BioMed Central Ltd., part of Springer Nature.)
Published: 2023
Full Text: View/download PDF

27. Abemaciclib restricts HCMV replication by suppressing pUL97-mediated phosphorylation of SAMHD1.

Author: Syrigos GV, Feige M, Dirlam A, Businger R, Gruska I, Wiebusch L, Hamprecht K, and Schindler M
Subjects: Infant, Newborn, Humans, Phosphorylation, SAM Domain and HD Domain-Containing Protein 1, Virus Replication, Cytomegalovirus, Antiviral Agents pharmacology
Abstract: Human cytomegalovirus (HCMV) is a herpesvirus that causes life-threatening infections in newborns or immunosuppressed patients. For viral replication, HCMV establishes a network of cellular interactions, among others cyclin-dependent kinases (CDK). Furthermore, HCMV encodes pUL97, a viral kinase, which is a CDK-homologue. HCMV uses pUL97 in order to phosphorylate and thereby antagonize SAMHD1, an antiviral host cell factor. Since HCMV has several mechanisms to evade restriction by SAMHD1, we first analyzed the kinetics of SAMHD1-inactivation and found that phosphorylation of SAMHD1 by pUL97 occurs directly after infection of macrophages. We hence hypothesized that inhibition of this process qualifies as efficient antiviral target and FDA approved CDK-inhibitors (CDKIs) might be potent antivirals that prevent the inactivation of SAMHD1. Indeed, Abemaciclib, a 2nd generation CDKI exhibited superior IC50s against HCMV in infected macrophages and the antiviral activity largely relied on its ability to block pUL97-mediated SAMHD1-phosphorylation. Altogether, our study highlights the therapeutic potential of clinically-approved CDKIs as antivirals against HCMV, sheds light on their mode of action and establishes SAMHD1 as a valid and highly potent therapeutic target., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)
Published: 2023
Full Text: View/download PDF

28. Evidence for direct interaction between the oncogenic proteins E6 and E7 of high-risk human papillomavirus (HPV).

Author: Lim J, Lilie H, Kalbacher H, Roos N, Frecot DI, Feige M, Conrady M, Votteler T, Cousido-Siah A, Corradini Bartoli G, Iftner T, Trave G, and Simon C
Subjects: Animals, Humans, Carcinogenesis, Human Papillomavirus Viruses, Neoplasms, Human papillomavirus 16 genetics, Human papillomavirus 16 metabolism, Oncogene Proteins, Viral genetics, Oncogene Proteins, Viral metabolism, Papillomavirus E7 Proteins genetics, Papillomavirus E7 Proteins metabolism, Papillomavirus Infections
Abstract: Human papillomaviruses (HPVs) are DNA tumor viruses that infect mucosal and cutaneous epithelial cells of more than 20 vertebrates. High-risk HPV causes about 5% of human cancers worldwide, and the viral proteins E6 and E7 promote carcinogenesis by interacting with tumor suppressors and interfering with many cellular pathways. As a consequence, they immortalize cells more efficiently in concert than individually. So far, the networks of E6 and E7 with their respective cellular targets have been studied extensively but independently. However, we hypothesized that E6 and E7 might also interact directly with each other in a novel interaction affecting HPV-related carcinogenesis. Here, we report a direct interaction between E6 and E7 proteins from carcinogenic HPV types 16 and 31. We demonstrated this interaction via cellular assays using two orthogonal methods: coimmunoprecipitation and flow cytometry-based FRET assays. Analytical ultracentrifugation of the recombinant proteins revealed that the stoichiometry of the E6/E7 complex involves two E7 molecules and two E6 molecules. In addition, fluorescence polarization showed that (I) E6 binds to E7 with a similar affinity for HPV16 and HPV31 (in the same micromolar range) and (II) that the binding interface involves the unstructured N-terminal region of E7. The direct interaction of these highly conserved papillomaviral oncoproteins may provide a new perspective for studying HPV-associated carcinogenesis and the overall viral life cycle., Competing Interests: Conflict of interest The authors declare that they have no conflicts of interest with the contents of this article., (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)
Published: 2023
Full Text: View/download PDF

29. Septic Deep Vein Thrombosis After Heroin Use.

Author: Feige M and Amann W
Subjects: Humans, Heroin adverse effects, Venous Thrombosis diagnostic imaging, Venous Thrombosis etiology
Published: 2023
Full Text: View/download PDF

30. Comparison of the '4-item assessment test' and 'nursing delirium screening scale' delirium screening tools on non-intensive care unit wards: A prospective mixed-method approach.

Author: Zastrow I, Tohsche P, Loewen T, Vogt B, Feige M, Behnke M, Wolff A, Kiefmann R, and Olotu C
Subjects: Aged, Hospitals, Humans, Mass Screening, Prospective Studies, Surveys and Questionnaires, Delirium diagnosis
Abstract: Background: In elderly patients following surgery, postoperative delirium (POD) is the most frequent complication and is associated with negative outcomes. The 2017 European Society of Anaesthesiology guideline on POD aims to improve patient care by implementing structured delirium prevention, diagnosis and treatment. However, these recommendations, especially systematic delirium screening, are still incompletely adopted in clinical practice. The aim of this study was to evaluate the feasibility and acceptance of validated delirium screening tools and to identify barriers to their implementation on nonintensive care unit wards., Methods: Screening rates, as well as practicability, acceptance and the interprofessional handling of positive results, were assessed for each group. Screening rates were calculated as a percentage of the total potential testing episodes completed (up to 15 per patient). Patients were considered eligible when aged 65 years and above. Barriers and motivating factors were assessed in a mixed method approach by utilising questionnaires and focus group discussions., Intervention: In a 3-month phase, a guideline-compliant screening protocol involving screening for POD three times daily for 5 days following surgery was introduced in five wards: both the 4-item assessment test (4AT) and the nursing delirium screening scale (NuDESC) were used. Before commencing the study and again after 6 weeks, medical staff of the respective wards underwent a 45 min training session., Results: Of a total of 3183 potential testing episodes, 999 (31.4%) were completed, with more NuDESC observational tests (43%) than 4AT bedside tests completed (20%). The 4AT was considered more difficult to integrate into daily working routines, it took longer to administer, and nurses felt uncomfortable conducting the screening (53 vs. 13%). Screening results indicating delirium were often not discussed within the team (47%), and nurses felt that often such results were not taken seriously by physicians (54%)., Conclusion: The observational NuDESC showed a higher completion rate than the bedside 4AT, although overall testing rates were low. The necessary time needed to conduct the screening, the negative reactions by patients, insufficient team communication and a lack of initiation of any therapy were identified as major barriers in the implementation of the guideline-compliant screening protocol. For all staff, further education and awareness of the importance of POD diagnosis and treatment might improve the screening rates. The NuDesc received better results concerning acceptance, practicability and introduction into daily work routine, leading to higher screening rates compared with the 4AT. The latter instrument, which was intended to be used rather selectively or when POD is suspected, might therefore not be suitable for guideline-compliant regular and repeated screening for POD., (Copyright © 2021 European Society of Anaesthesiology and Intensive Care. Unauthorized reproduction of this article is prohibited.)
Published: 2021
Full Text: View/download PDF

31. Evaluations of a Detector-Limited Digital Impedance Bridge.

Author: Feige M, Schlamminger S, Waltrip B, Berilla M, and Wang Y
Abstract: We tested a simple digital impedance bridge using two nominally equal resistors to form a 1:1 ratio. We focused on resolution and stability of the detectors. Fluctuations of the source voltages were largely removed through postprocessing of the digitized data, and the measurement results were limited by the detector noise. This detector-limited operating condition was first demonstrated using three modified Keysight 3458A multimeters for measurements of the voltage ratios, achieving 0.01 μV/V type A uncertainty in less than 15 min at 1 kHz. In an effort to extend the applicable frequency range and develop a system with off-the-shelf components, we tested a system using three lock-in detectors for measuring small deviations from the perfect AC ratio of unity magnitude, achieving stabilities and resolutions of 0.1 μV/V in a few hours for each point from 1 kHz to 5 kHz.
Published: 2021
Full Text: View/download PDF

32. Comparison of a 100-pF Capacitor With a 12 906-Ω Resistor Using a Digital Impedance Bridge.

Author: Feige M, Schlamminger S, Koffman AD, Jarrett DG, Payagala S, Panna A, Waltrip BC, Berilla M, Seifert F, and Wang Y
Abstract: We tested a digital impedance bridge in a hybrid structure for comparison of a capacitor with a resistor where the impedance ratio was measured in two separate parts. The modulus of the impedance ratio was matched arbitrarily close to the input-to-output ratio, in magnitude, of a two-stage inductive voltage divider by adjusting the operating frequency of the bridge; the residual deviation between the two together with the phase factor of the impedance ratio was measured using a custom detection system based on a four-channel 24-bit digitizer. The ratio of the inductive voltage divider was calibrated, in situ , using a conventional four-arm bridge with two known capacitors. Fluctuations of the source voltages were largely removed through postprocessing of the digitized data, and the measurement results were limited by the digitizer error. We have achieved an overall bridge resolution and stability of 0.02 μF/F in 2 h for measuring a 100-pF capacitor relative to a 12 906-Ω resistor at 1233 Hz. The relative combined standard uncertainty ( k = 1) is 0.13 μF/F, dominated by the digitizer error.
Published: 2021
Full Text: View/download PDF

33. Racial/Ethnic Differences in Comprehension of Biospecimen Collection: a Nationwide University of Rochester Cancer Center NCI Community Oncology Research Program Study.

Author: Asare M, Heckler CE, Culakova E, Kamen CS, Kleckner AS, Minasian LM, Wendler DS, Feige M, Weil CJ, Long J, Cole SK, Onitilo AA, Peppone LJ, Morrow GR, and Janelsins MC
Subjects: Adult, Black or African American education, Aged, Aged, 80 and over, Breast Neoplasms drug therapy, Breast Neoplasms psychology, Case-Control Studies, Cross-Sectional Studies, Female, Health Knowledge, Attitudes, Practice, Humans, Middle Aged, Patient Participation, Specimen Handling, White People education, Young Adult, Biological Specimen Banks statistics & numerical data, Breast Neoplasms ethnology, Clinical Trials as Topic statistics & numerical data, Comprehension, Ethnicity education, Ethnicity psychology, Health Status Disparities
Abstract: To examine whether (a) non-minority participants differed from racial minority participants in the understanding of biospecimens collected for research purposes, (b) patients differed from comparison group in their understanding of the ways their biospecimens could be used by researchers, and (c) participants received adequate information before consenting to donate blood for research studies. We analyzed cross-sectional data from female breast cancer patients scheduled to receive chemotherapy at the National Cancer Institute (NCI) Community Oncology Research Program (NCORP) clinical sites and a healthy comparison group. After reading a consent form related to biospecimens and consenting to participate in a clinical trial, participants' understanding of biospecimen collection was evaluated. Linear models were used to compare scores between non-minority and racial minority participants as well as cancer and non-cancer comparisons adjusting for possible confounding factors. A total of 650 participants provided evaluable data; 592 were non-minority (Caucasian) and 58 participants were a racial minority (71% Black and 29% other). There were 427 cancer patients and 223 comparisons. Non-minority participants scored higher than racial minorities on relevance-to-care items (diff. = 0.48, CI 0.13-0.80, p = 0.001). Comparison group scored higher than cancer patients on relevance-to-care items (diff. = 0.58, CI 0.37-0.78). A moderate number of the participants exhibited a poor understanding of biospecimen collection across all racial/ethnic backgrounds, but racial minority participants' scores remained lower in the relevance-to-care subscale even after adjusting for education and reading level. Differences were also noted among the patients and comparison group. Researchers should facilitate comprehension of biospecimen collection for all study participants, especially racial minority participants.
Published: 2020
Full Text: View/download PDF

34. Broad Consent for Research on Biospecimens: The Views of Actual Donors at Four U.S. Medical Centers.

Author: Warner TD, Weil CJ, Andry C, Degenholtz HB, Parker L, Carithers LJ, Feige M, Wendler D, and Pentz RD
Subjects: Attitude to Health, Data Collection ethics, Donor Selection, Humans, Informed Consent psychology, Living Donors psychology, Tissue Donors ethics, United States, Biological Specimen Banks ethics, Informed Consent ethics, Living Donors ethics
Abstract: Commentators are concerned that broad consent may not provide biospecimen donors with sufficient information regarding possible future research uses of their tissue. We surveyed with interviews 302 cancer patients who had recently provided broad consent at four diverse academic medical centers. The majority of donors believed that the consent form provided them with sufficient information regarding future possible uses of their biospecimens. Donors expressed very positive views regarding tissue donation in general and endorsed the use of their biospecimens in future research across a wide range of contexts. Concerns regarding future uses were limited to for-profit research and research by investigators in other countries. These results support the use of broad consent to store and use biological samples in future research.
Published: 2018
Full Text: View/download PDF

35. The significance of DNA double-strand breaks in the UV inactivation of yeast cells.

Author: Kiefer J and Feige M
Subjects: DNA, Fungal isolation & purification, Dose-Response Relationship, Radiation, Mutation, Saccharomyces cerevisiae genetics, Temperature, DNA Damage, DNA, Fungal genetics, DNA, Fungal radiation effects, Saccharomyces cerevisiae radiation effects, Ultraviolet Rays
Abstract: The radiation-sensitive mutant rad 54-3 of Saccharomyces cerevisiae temperature-conditional for the repair of DNA double-strand breaks was exposed to 254 nm ultraviolet radiation and incubated at the restrictive and permissive temperatures. A large difference in survival was seen indicating the involvement of double-strand breaks in cellular inactivation at least in this strain. Pulsed-field gel electrophoresis of DNA showed that double-strand breaks are not directly induced but develop upon incubation under growth conditions. Their number is highest after about 4 h, after 8 h repair is complete in wild-type cells. With the aid of the excision-deficient double mutant rad3rad54 it could be demonstrated that strand break formation proceeds independent of excision repair.
Published: 1993
Full Text: View/download PDF

36. Establishing standard rehabilitation evaluation forms. Arizona Association for Home Care.

Author: Feige M
Subjects: Arizona, Contract Services, Disability Evaluation, Documentation standards, Home Care Services standards, Humans, Occupational Therapy organization & administration, Occupational Therapy standards, Physical Therapy Modalities organization & administration, Physical Therapy Modalities standards, Rehabilitation standards, Speech Therapy organization & administration, Speech Therapy standards, Forms and Records Control standards, Home Care Services organization & administration, Medical Records standards, Patient Care Planning standards, Rehabilitation organization & administration
Abstract: Contract therapists work with several agencies, providing the same services to patients. Evaluation forms for these different agencies are many and varied, although the forms ask for the same information. Therapists' time would be better served--and thus so would patients--with the institution of standardized forms.
Published: 1992

37. [The effect of various food energy sources on the lipid metabolism. 3. Incorporation of radiocarbons from U14C glucose, U14C fructose and 1(14)c-fatty acids into the body lipids].

Author: Abel H, Rosenow H, Feige M, and Molnár S
Subjects: Animals, Fatty Acids metabolism, Fructose metabolism, Glucose metabolism, Lipids biosynthesis, Rats, Energy Metabolism
Published: 1976

38. [Pulmonary hypertension and cor pulmonale complicating ventricular vascular shunting for hydrocephalus (author's transl)].

Author: Keck EW, Feige M, and Riesner K
Subjects: Child, Preschool, Electrocardiography, Humans, Hydrocephalus surgery, Hypertension, Pulmonary diagnosis, Phonocardiography, Pulmonary Heart Disease diagnosis, Pulmonary Heart Disease diagnostic imaging, Radiography, Cerebrospinal Fluid Shunts adverse effects, Hypertension, Pulmonary etiology, Pulmonary Heart Disease etiology
Abstract: Obstructive pulmonary vascular disease and pulmonary hypertension are facts daily encountered by pediatric cardiologists. However longterm thromboembolism, pulmonary vascular obstruction and cor pulmonale are rare conditions in children. The case report of a four years old child treated by a Pudenz ventriculo venous shunt for hydrocephalus is presented. Due to fibrin thromboembolism from the Pudenz shunting tube pulmonary vascular obliteration, pulmonary hypertension and chronic cor pulmonale developed. The autopsy findings are in agreement with the ECG, x-ray, cardiac catheterization data and the angiocardiogram.
Published: 1978

39. [Results of the immunodiffusion test in the diagnosis of cattle leukosis].

Author: Albrecht A, Feige M, Heinert H, Mitscherlich E, Schmidt FW, and van der Wall G
Subjects: Animals, Antibody Formation, Cattle, Cattle Diseases diagnosis, Immunodiffusion, Leukemia diagnosis, Cattle Diseases immunology, Leukemia veterinary
Published: 1976

40. [Experimental wound grafting adhesion in artificial hypospadias without double-step sutures or urine catheterization].

Author: Vahlensieck W, Feige M, and Ehring H
Subjects: Animals, Collagen therapeutic use, Dogs, Edema prevention & control, Gossypium, Humans, Male, Methods, Postoperative Care, Saponins therapeutic use, Skin Transplantation, Surgery, Plastic instrumentation, Transplantation, Autologous, Hypospadias surgery, Tissue Adhesives
Published: 1969

Catalog

Books, media, physical & digital resources

See catalog results

Searchworks

Select search scope, currently: Articles Catalog books, media & more in Jio Institute collections Articles journal articles & other e-resources

Search

Search Constraints

Refine your results

Search Limiters

Topic

Publication Year Range

Language

Publication Type

Journal

Region

Database

Publisher

40 results on '"Feige, M."'

Search Results

Catalog

Select search scope, currently: Articles

Catalog

books, media & more in Jio Institute collections

Articles

journal articles & other e-resources