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INFAT®PLUS, is a sn-2 palmitate enriched fat ingredient intended for infant formula. A battery of toxicological studies was conducted in accordance with the Food Safety Toxicological Assessment GB-15193 (China), to confirm the safety of INFAT®PLUS. In the acute oral toxicity test, the LD50 of INFAT® PLUS was higher than 53.4 g /kg BW and 26.7 g/kg BW for ICR mice and SD rats, respectively. In a subchronic study, INFAT® PLUS was administered by oral gavage to SD rats with maximal daily dose of 8.90 g/kg BW for 90 days. No treatment-related clinical signs or mortalities were observed. The no-observed-adverse-effect level (NOAEL) was set at 8.90 g/kg BW. Similarly, no evidence of genotoxicity effect was noted in several in vitro and in vivo tests, including bacterial reverse mutation (Ames) test, mouse erythrocyte micronucleus test, and chromosome aberration test of mouse spermatogonia/spermatocyte. For the teratogenic evaluations, no toxicological signs were observed in both pregnant SD rat and fetuses, and the NOAEL of INFAT® PLUS was determined to be 8.90 g/kg BW. Based on the obtained results we concluded that INFAT® PLUS was found non-toxic under the experimental conditions, and the totality of the safety data supports its use for infant nutrition.

The economic development of tight carbonate reservoirs requires hydraulic or acid fracturing stimulation. Acid fracturing better activates natural fractures, resulting in increased stimulated reservoir volume and improving oil and gas flowability. In order to solve the problem of excessive acid-rock reaction due to high temperature, this paper screened four kinds of solid forms of acid with the maximum quantity of acid and reaction rate as the index and formed a high temperature-resistant mixed solid acid system with solid organic acid as the main part and inorganic solid acid as the auxiliary part. The maximum quantity of acid produced and effective acid concentration of the system were greater than 50%, and no residue was precipitated after the complete reaction. Dynamic acid-rock rate tests were performed on different types of retarded acid at 140 °C. The test results show that the solid acid dissolves to form a low-viscosity acid solution, and the reaction rate is one order of magnitude lower than that of gelled and cross-linked acids at the same hydrogen ion concentration, and it is little affected by temperature. Moreover, the paper compares the treatment effect of micro-proppants and solid acids on micro-fractures. The results show that the core permeability improvement multiples up to 900 times under low dissolution of solid acid and the formation of oil and gas flow channels with the same scale as micro-proppants. The experimental results demonstrated the ability of solid delayed acid to transport the fracture leading edge at high temperatures and effectively activate micro-fractures. [ABSTRACT FROM AUTHOR]