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3. Comprehensive whole-genome sequence analyses provide insights into the genomic architecture of cerebral palsy

Author

Fehlings, Darcy L., Zarrei, Mehdi, Engchuan, Worrawat, Sondheimer, Neal, Thiruvahindrapuram, Bhooma, MacDonald, Jeffrey R., Higginbotham, Edward J., Thapa, Ritesh, Behlim, Tarannum, Aimola, Sabrina, Switzer, Lauren, Ng, Pamela, Wei, John, Danthi, Prakroothi S., Pellecchia, Giovanna, Lamoureux, Sylvia, Ho, Karen, Pereira, Sergio L., de Rijke, Jill, Sung, Wilson W. L., Mowjoodi, Alireza, Howe, Jennifer L., Nalpathamkalam, Thomas, Manshaei, Roozbeh, Ghaffari, Siavash, Whitney, Joseph, Patel, Rohan V., Hamdan, Omar, Shaath, Rulan, Trost, Brett, Knights, Shannon, Samdup, Dawa, McCormick, Anna, Hunt, Carolyn, Kirton, Adam, Kawamura, Anne, Mesterman, Ronit, Gorter, Jan Willem, Dlamini, Nomazulu, Merico, Daniele, Hilali, Murto, Hirschfeld, Kyle, Grover, Kritika, Bautista, Nelson X., Han, Kara, Marshall, Christian R., Yuen, Ryan K. C., Subbarao, Padmaja, Azad, Meghan B., Turvey, Stuart E., Mandhane, Piush, Moraes, Theo J., Simons, Elinor, Maxwell, George, Shevell, Michael, Costain, Gregory, Michaud, Jacques L., Hamdan, Fadi F., Gauthier, Julie, Uguen, Kevin, Stavropoulos, Dimitri J., Wintle, Richard F., Oskoui, Maryam, and Scherer, Stephen W.

Published
2024
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7. Early Intervention for Children Aged 0 to 2 Years With or at High Risk of Cerebral Palsy

Author

Morgan, Catherine, Fetters, Linda, Adde, Lars, Badawi, Nadia, Bancale, Ada, Boyd, Roslyn N, Chorna, Olena, Cioni, Giovanni, Damiano, Diane L, Darrah, Johanna, de Vries, Linda S, Dusing, Stacey, Einspieler, Christa, Eliasson, Ann-Christin, Ferriero, Donna, Fehlings, Darcy, Forssberg, Hans, Gordon, Andrew M, Greaves, Susan, Guzzetta, Andrea, Hadders-Algra, Mijna, Harbourne, Regina, Karlsson, Petra, Krumlinde-Sundholm, Lena, Latal, Beatrice, Loughran-Fowlds, Alison, Mak, Catherine, Maitre, Nathalie, McIntyre, Sarah, Mei, Cristina, Morgan, Angela, Kakooza-Mwesige, Angelina, Romeo, Domenico M, Sanchez, Katherine, Spittle, Alicia, Shepherd, Roberta, Thornton, Marelle, Valentine, Jane, Ward, Roslyn, Whittingham, Koa, Zamany, Alieh, and Novak, Iona

Subjects
Prevention, Pediatric, Brain Disorders, Cerebral Palsy, Clinical Research, Clinical Trials and Supportive Activities, Neurosciences, Rehabilitation, Behavioral and Social Science, Perinatal Period - Conditions Originating in Perinatal Period, Child, Preschool, Early Diagnosis, Early Intervention, Educational, Humans, Infant, Infant, Newborn, Parents, Practice Guidelines as Topic, Paediatrics and Reproductive Medicine, Pediatrics
Abstract

ImportanceCerebral palsy (CP) is the most common childhood physical disability. Early intervention for children younger than 2 years with or at risk of CP is critical. Now that an evidence-based guideline for early accurate diagnosis of CP exists, there is a need to summarize effective, CP-specific early intervention and conduct new trials that harness plasticity to improve function and increase participation. Our recommendations apply primarily to children at high risk of CP or with a diagnosis of CP, aged 0 to 2 years.ObjectiveTo systematically review the best available evidence about CP-specific early interventions across 9 domains promoting motor function, cognitive skills, communication, eating and drinking, vision, sleep, managing muscle tone, musculoskeletal health, and parental support.Evidence reviewThe literature was systematically searched for the best available evidence for intervention for children aged 0 to 2 years at high risk of or with CP. Databases included CINAHL, Cochrane, Embase, MEDLINE, PsycInfo, and Scopus. Systematic reviews and randomized clinical trials (RCTs) were appraised by A Measurement Tool to Assess Systematic Reviews (AMSTAR) or Cochrane Risk of Bias tools. Recommendations were formed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework and reported according to the Appraisal of Guidelines, Research, and Evaluation (AGREE) II instrument.FindingsSixteen systematic reviews and 27 RCTs met inclusion criteria. Quality varied. Three best-practice principles were supported for the 9 domains: (1) immediate referral for intervention after a diagnosis of high risk of CP, (2) building parental capacity for attachment, and (3) parental goal-setting at the commencement of intervention. Twenty-eight recommendations (24 for and 4 against) specific to the 9 domains are supported with key evidence: motor function (4 recommendations), cognitive skills (2), communication (7), eating and drinking (2), vision (4), sleep (7), tone (1), musculoskeletal health (2), and parent support (5).Conclusions and relevanceWhen a child meets the criteria of high risk of CP, intervention should start as soon as possible. Parents want an early diagnosis and treatment and support implementation as soon as possible. Early intervention builds on a critical developmental time for plasticity of developing systems. Referrals for intervention across the 9 domains should be specific as per recommendations in this guideline.

Published
2021

8. Pharmacological and neurosurgical management of cerebral palsy and dystonia: Clinical practice guideline update.

Author

Fehlings, Darcy, Agnew, Brenda, Gimeno, Hortensia, Harvey, Adrienne, Himmelmann, Kate, Lin, Jean‐Pierre, Mink, Jonathan W., Monbaliu, Elegast, Rice, James, Bohn, Emma, and Falck‐Ytter, Yngve

Abstract

Dystonia, typically characterized by slow repetitive involuntary movements, stiff abnormal postures, and hypertonia, is common among individuals with cerebral palsy (CP). Dystonia can interfere with activities and have considerable impact on motor function, pain/comfort, and ease of caregiving. Although pharmacological and neurosurgical approaches are used clinically in individuals with CP and dystonia that is causing interference, evidence to support these options is limited. This clinical practice guideline update comprises 10 evidence‐based recommendations on the use of pharmacological and neurosurgical interventions for individuals with CP and dystonia causing interference, developed by an international expert panel following the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. The recommendations are intended to help inform clinicians in their use of these management options for individuals with CP and dystonia, and to guide a shared decision‐making process in selecting a management approach that is aligned with the individual's and the family's values and preferences. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Randomized Trial of Oral Iron and Diet Advice versus Diet Advice Alone in Young Children with Nonanemic Iron Deficiency

Author

Stoneman, Charles Keown, Malhi, Tarandeep, Thompson, Julia, Kowal, Christine, Mason, Dalah, Thompson, Laurie, Barozzino, Tony, Campbell, Douglas, Chisamore, Brian, Danayan, Karoon, Do, Anh, Jacobson, Sheila, Kadar, Paul, Lau, Eddy, Naymark, Sharon, Peer, Michael, Perlmutar, Marty, Persaud, Nav, Saunderson, Janet, Sgro, Michael, Wong, Peter, Zajdman, Michael, Parkin, Patricia C., Borkhoff, Cornelia M., Macarthur, Colin, Abdullah, Kawsari, Birken, Catherine S., Fehlings, Darcy, Koroshegyi, Christine, Maguire, Jonathon L., Mamak, Eva, Mamdani, Muhammad, Thorpe, Kevin E., Zlotkin, Stanley H., and Zuo, Fei

Published
2021
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13. Early, Accurate Diagnosis and Early Intervention in Cerebral Palsy: Advances in Diagnosis and Treatment

Author

Novak, Iona, Morgan, Cathy, Adde, Lars, Blackman, James, Boyd, Roslyn N, Brunstrom-Hernandez, Janice, Cioni, Giovanni, Damiano, Diane, Darrah, Johanna, Eliasson, Ann-Christin, de Vries, Linda S, Einspieler, Christa, Fahey, Michael, Fehlings, Darcy, Ferriero, Donna M, Fetters, Linda, Fiori, Simona, Forssberg, Hans, Gordon, Andrew M, Greaves, Susan, Guzzetta, Andrea, Hadders-Algra, Mijna, Harbourne, Regina, Kakooza-Mwesige, Angelina, Karlsson, Petra, Krumlinde-Sundholm, Lena, Latal, Beatrice, Loughran-Fowlds, Alison, Maitre, Nathalie, McIntyre, Sarah, Noritz, Garey, Pennington, Lindsay, Romeo, Domenico M, Shepherd, Roberta, Spittle, Alicia J, Thornton, Marelle, Valentine, Jane, Walker, Karen, White, Robert, and Badawi, Nadia

Subjects
Clinical Research, Perinatal Period - Conditions Originating in Perinatal Period, Biomedical Imaging, Cerebral Palsy, Brain Disorders, Prevention, Pediatric, Neurosciences, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Neurological, Child, Early Diagnosis, Early Intervention, Educational, Humans, Infant, Infant, Newborn, Paediatrics and Reproductive Medicine, Pediatrics
Abstract

ImportanceCerebral palsy describes the most common physical disability in childhood and occurs in 1 in 500 live births. Historically, the diagnosis has been made between age 12 and 24 months but now can be made before 6 months' corrected age.ObjectivesTo systematically review best available evidence for early, accurate diagnosis of cerebral palsy and to summarize best available evidence about cerebral palsy-specific early intervention that should follow early diagnosis to optimize neuroplasticity and function.Evidence reviewThis study systematically searched the literature about early diagnosis of cerebral palsy in MEDLINE (1956-2016), EMBASE (1980-2016), CINAHL (1983-2016), and the Cochrane Library (1988-2016) and by hand searching. Search terms included cerebral palsy, diagnosis, detection, prediction, identification, predictive validity, accuracy, sensitivity, and specificity. The study included systematic reviews with or without meta-analyses, criteria of diagnostic accuracy, and evidence-based clinical guidelines. Findings are reported according to the PRISMA statement, and recommendations are reported according to the Appraisal of Guidelines, Research and Evaluation (AGREE) II instrument.FindingsSix systematic reviews and 2 evidence-based clinical guidelines met inclusion criteria. All included articles had high methodological Quality Assessment of Diagnostic Accuracy Studies (QUADAS) ratings. In infants, clinical signs and symptoms of cerebral palsy emerge and evolve before age 2 years; therefore, a combination of standardized tools should be used to predict risk in conjunction with clinical history. Before 5 months' corrected age, the most predictive tools for detecting risk are term-age magnetic resonance imaging (86%-89% sensitivity), the Prechtl Qualitative Assessment of General Movements (98% sensitivity), and the Hammersmith Infant Neurological Examination (90% sensitivity). After 5 months' corrected age, the most predictive tools for detecting risk are magnetic resonance imaging (86%-89% sensitivity) (where safe and feasible), the Hammersmith Infant Neurological Examination (90% sensitivity), and the Developmental Assessment of Young Children (83% C index). Topography and severity of cerebral palsy are more difficult to ascertain in infancy, and magnetic resonance imaging and the Hammersmith Infant Neurological Examination may be helpful in assisting clinical decisions. In high-income countries, 2 in 3 individuals with cerebral palsy will walk, 3 in 4 will talk, and 1 in 2 will have normal intelligence.Conclusions and relevanceEarly diagnosis begins with a medical history and involves using neuroimaging, standardized neurological, and standardized motor assessments that indicate congruent abnormal findings indicative of cerebral palsy. Clinicians should understand the importance of prompt referral to diagnostic-specific early intervention to optimize infant motor and cognitive plasticity, prevent secondary complications, and enhance caregiver well-being.

Published
2017

15. Physician Approaches to the Pharmacologic Treatment of Dystonia in Cerebral Palsy.

Author

Lott, Emma, Fehlings, Darcy, Gelineau-Morel, Rose, Kruer, Michael, Mink, Jonathan W., Thomas, Sruthi P., Wisniewski, Steve, and Aravamuthan, Bhooma

Subjects
*DRUG dosage, *BACLOFEN, *HETEROCYCLIC compounds, *CANNABIDIOL, *DIAZEPAM, *RESEARCH funding, *PIPERIDINE, *METHYLDOPA, *CLONIDINE, *CEREBRAL palsy, *DESCRIPTIVE statistics, *DECISION making in clinical medicine, *SEVERITY of illness index, *FUNCTIONAL status, *PHYSICIANS' attitudes, *INJECTIONS, *SPASTICITY, *DYSTONIA, *PHYSICIAN practice patterns, *GABAPENTIN, *DRUG efficacy, *PAIN, *RETENTION of urine, *PHYSICIANS, *DRUG prescribing, *DRUGS, *CLONAZEPAM, *DRUG utilization, *DOPA, *CLOBAZAM, *CONSTIPATION, *DISEASE complications
Abstract

The article discusses research which investigated physician approaches to the pharmacologic dystonia treatment in people with cerebral palsy. The study surveyed physician approaches regarding medications for dystonia in CP including baclofen, trihexyphenidyl, gabapentin, carbidopa/levodopa, clonazepam, diazepam, clonidine, tetrabenazine, clobazam and cannabidiol. It described physician's prescribing practices and choice of medications for dystonia.

Published
2024
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16. Current Referral Practices for Diagnosis and Intervention for Children with Cerebral Palsy: A National Environmental Scan

Author

Bergman, Howard, Burko, Benjamin, Dagenais, Emmanuelle, Dagenais, Lynn, Darsaklis, Vasiliki Betty, Leduc, Denis, Li, Patricia, Shiller, Mitchell, Snider, Laurie, Thibault, Julie, Ahmed, Sara, Bussières, André, Rodriguez, Rosario, Shikako Thomas, Keiko, Boychuck, Zachary, Andersen, John, Fehlings, Darcy, Kirton, Adam, Oskoui, Maryam, Shevell, Michael, and Majnemer, Annette

Published
2020
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19. The Hammersmith Infant Neurological Exam Scoring Aid supports early detection for infants with high probability of cerebral palsy.

Author

Fehlings, Darcy, Makino, Amber, Church, Paige, Banihani, Rudaina, Thomas, Karen, Luther, Maureen, Lam‐Damji, Sophie, Vollmer, Brigitte, Haataja, Leena, Cowan, Frances, Romeo, Domenico M., George, Joanne, and Kumar, Swetlana

Abstract

This letter to the editor is in response to the original articles by Romeo et al. and Tian et al. on pages 1173–1180 and 1181–1189 of this issue. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Answering the call: co-designing a global trials network for cerebral palsy

Author

Adde, Lars, Arnaud, Catherine, Brandao, Marina, Brochard, Sylvain, Buizer, Annemieke, Craig, Simon, Dan, Bernard, Fahey, Michael, Fairhurst, Charlie, Fehlings, Darcy, Friel, Kathleen, Gross, Paul, Guzzetta, Andrea, Eliasson, Ann-Christin, Høi-Hansen, Christina, Jahnsen, Reidun Birgitta, Johansen, Mette, Mwesige, Angelina Kakooza, Ketelaar, Marjolijn, Lind, Karin, Longo, Egmar, Maimann, Bente, Namara, Maria Mc, Mesterman, Ronit, Mitchell, Jenna, Monbaliu, Elegast, Morgan, Catherine, Newman, Christopher J., Nielsen, Jens Bo, Novak, Iona, Ortibus, Els, Rackauskaite, Gija, Ritterband-Rosenbaum, Anina, Sigurdardottir, Solveig, Snelling, Tom, Shrader, M. Wade, Griffin, Alexandra, Justiniano, Mikkel Damgaard, Webb, Annabel, and Snelling, Thomas

Published
2024
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23. Clinical actionability of genetic findings in cerebral palsy

Author

Lewis, Sara A, primary, Chopra, Maya, additional, Cohen, Julie S., additional, Bain, Jennifer, additional, Aravamuthan, Bhooma, additional, Carmel, Jason B, additional, Fahey, Michael C, additional, Segel, Reeval, additional, Wintle, Richard F, additional, Zech, Michael, additional, May, Halie, additional, Haque, Nahla, additional, Fehlings, Darcy, additional, Srivastava, Siddharth, additional, and Kruer, Michael C, additional

Published
2023
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28. Validating Accelerometry as a Measure of Arm Movement for Children With Hemiplegic Cerebral Palsy

Author

Dawe, Jaclyn, Yang, Jaynie F., Fehlings, Darcy, Likitlersuang, Jirapat, Rumney, Peter, Zariffa, Jose, and Musselman, Kristin E.

Subjects
Cerebral palsy, Pediatrics, Child development, Pediatricians, Hemiplegia, Handbooks, Children, Health, University of Toronto, University Health Network
Abstract

Background. For children with hemiplegic cerebral palsy (HCP), rehabilitation aims to increase movement of the affected arm. However, no validated measure objectively examines this construct in pediatric practice or daily life. Objective. The objective of this study was to evaluate the criterion and known-groups validity of accelerometry as a measure of arm movement in children and adolescents with HCP. Design. This was a prospective cross-sectional study. Methods. Twenty-seven children and adolescents with typical development (3.4-13.9 years old) and 11 children and adolescents with HCP (4.7-14.7 years old; Manual Ability Classification System rating I or II) wore accelerometers on their wrists while engaged in 20 minutes of play, which included intermittent intervals of stillness and vigorous movement of the arms. Vector magnitude (VM) values identified the presence (VM > 2.0 counts per epoch) and absence (VM [less than or equal to] 2.0 counts per epoch) of arm movement for every 2-second epoch. Video was simultaneously recorded; each 2-second interval of footage was scored as 'movement' or 'no movement' for each arm. Results. Agreement between accelerometry and video observation was greater than or equal to 81%, and the prevalence-adjusted and bias-adjusted K value was greater than or equal to 0.69 for both groups of participants; these results supported the criterion validity of accelerometry. The ratio of nondominant arm movement to dominant arm movement measured by accelerometry was significantly greater in participants with typical development (mean [SD] = 0.87 [0.09]) than in participants with HCP (mean = 0.78 [0.07]) on the basis of 10 age- and sex-matched pairs; these results supported known-groups validity. Limitations. The small sample size of the group with HCP prevented the stratification of data by age. Participants with HCP had high or moderately high function of the affected arm; hence, the findings do not apply to children and adolescents with more significant hemiparesis. Conclusions. Accelerometry is a valid measure of arm movement in children with HCP and children without HCP. These findings contribute to the development of innovative upper limb assessments for children with hemiparesis., Hemiparetic cerebral palsy (HCP) is the most common form of cerebral palsy (CP), which is the leading cause of physical disability in childhood. (1,2) HCP is characterized by 1-sided impairments [...]

Published
2019
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29. Whole Genome Sequencing to Resolve the Genomic Architecture of Cerebral Palsy in a Canadian Cohort (P13-9.003)

Author

Oskoui, Maryam, primary, Zarrei, Mehdi, additional, Engchuan, Worrawat, additional, Sondheimer, Neal, additional, Thiruv, Bhooma, additional, Higginbotham, Edward, additional, Thapa, Ritesh, additional, Behlim, Tarannum, additional, Aimola, Sabrina, additional, Wei, John, additional, Danthi, Prakroothi, additional, Pellecchia, Giovanna, additional, Ho, Karen, additional, de Rijke, Jill, additional, Howe, Jennifer, additional, Nalpathamkalam, Thomas, additional, Manshaei, Roozbeh, additional, Whitney, Joseph, additional, Patel, Rohan, additional, Hamdan, Omar, additional, Shaath, Rulan, additional, Knights, Shannon, additional, Trost, Brett, additional, Samdup, Dawa, additional, MCCORMICK, ANNA, additional, Hunt, Carolyn, additional, Kirton, Adam, additional, Kawamura, Anne, additional, Mesterman, Ronit, additional, Gorter, Jan Willem, additional, Dlamini, Nomazulu, additional, Merico, Daniele, additional, Yuen, Ryan, additional, Shevell, Michael, additional, Stavropoulos, Dimitri, additional, Wintle, Richard, additional, Fehlings, Darcy, additional, and Scherer, Stephen, additional

Published
2023
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42. Contributors

Author

Aaen, Gregory S., primary, Abend, Nicholas Scott, additional, Abou-Hamden, Amal, additional, Allen, Jeffrey C., additional, Amato, Anthony A., additional, Amlie-Lefond, Catherine, additional, Ashwal, Stephen, additional, Bailey, Russell C., additional, Bale, James F., additional, Banwell, Brenda, additional, Barañano, Kristin W., additional, Barkovich, A. James, additional, Barohn, Richard J., additional, Bartels, Ute K., additional, Bartnik-Olson, Brenda, additional, Barzilai, Ori, additional, Bassuk, Alexander, additional, Bearden, David R., additional, Ben-Sira, Liat, additional, Bernard, Timothy J., additional, Berry-Kravis, Elizabeth, additional, Beslow, Lauren A., additional, Biegel, Jaclyn A., additional, Billinghurst, Lori, additional, Birnbaum, Angela K., additional, Blackburn, Joanna S., additional, Bobowski, Nuala, additional, Boire, Adrienne, additional, Bönnemann, Carsten G., additional, Bonifacio, Sonia L., additional, Bonthius, Daniel J., additional, Borcherding, Breck, additional, Branchford, Brian R., additional, Brandsema, John, additional, Brennan, Kathryn M., additional, Brenton, J. Nicholas, additional, Brooks-Kayal, Amy R., additional, Brown, Lawrence W., additional, Buchalter, Jeffrey, additional, Camfield, Carol S., additional, Camfield, Peter R., additional, Campoy, Cristina, additional, Carpenter, Jessica L., additional, Chang, Taeun, additional, Chau, Vann, additional, Chi, Susan N., additional, Chiriboga, Claudia A., additional, Cho, Yoon-Jae, additional, Christian, Cindy W., additional, Chrestian, Nicholas, additional, Cilio, Maria Roberta, additional, Clark, Robin D., additional, Cohen, Bruce H., additional, Cohn, Ronald D., additional, Connolly, Anne M., additional, Constable, Todd, additional, Constantini, Shlomi, additional, Conway, Jeannine M., additional, Coulter, David L., additional, Cowan, Tina M., additional, Dale, Russell C., additional, Darbro, Benjamin, additional, Darras, Basil T., additional, Dastgir, Jahannaz, additional, De Meirleir, Linda, additional, De Vivo, Darryl C., additional, de Vries, Linda S., additional, Deisch, Jeremy K., additional, Deltenre, Paul, additional, Desai, Jay, additional, Descartes, Maria, additional, deVeber, Gabrielle, additional, Dhamne, Sameer C., additional, Diaz, Jullianne, additional, DiMauro, Salvatore, additional, Dobyns, William B., additional, Doherty, Dan, additional, Donner, Elizabeth J., additional, Dosenbach, Nico U.F., additional, Dowling, James J., additional, Drake, James M., additional, Ejerskov, Cecile, additional, Engel, Andrew G., additional, Enns, Gregory M., additional, Escolano-Margarit, María Victoria, additional, Etzion, Iris, additional, Fatemi, S. Ali, additional, Fehlings, Darcy L., additional, Feinberg, Michelle Lauren, additional, Ferriero, Donna M., additional, Filipek, Pauline A., additional, Finkel, Richard S., additional, Fisher, Paul G., additional, Flanigan, Kevin, additional, Foreman, Nicholas K., additional, Franco, Israel, additional, Frank, Yitzchak, additional, Fredrick, Douglas R., additional, Freeze, Hudson H., additional, Fuente-Mora, Cristina, additional, Furman, Joseph M., additional, Gallagher, Renata C., additional, Garel, Catherine, additional, Gertsch, Emily, additional, Gilbert, Donald L., additional, Gilles, Elizabeth E., additional, Giza, Christopher C., additional, Glaser, Carol A., additional, Glass, Hannah C., additional, Glauser, Tracy, additional, Glykys, Joseph, additional, Goldstein, Amy, additional, Gonorazky, Hernan Dario, additional, Gonzalez, Rodolfo, additional, Goodkin, Howard P., additional, Graham, John M., additional, Greninger, Alexander L., additional, Gronseth, Gary, additional, Gropman, Andrea L., additional, Grundy, Richard, additional, Guerrini, Renzo, additional, Gupta, Nalin, additional, Hahn, Jin S., additional, Hamblin, Milton H., additional, Hani, Abeer J., additional, Hanmantgad, Sharyu, additional, Harbert, Mary J., additional, Harini, Chellamani, additional, Harriott, Andrea M., additional, Heatwole, Chad, additional, Hershey, Andrew D., additional, Hirtz, Deborah G., additional, Holmes, Gregory L., additional, Holshouser, Barbara A., additional, Hurwitz, Kathleen A., additional, Hwang, Eugene, additional, Ichord, Rebecca N., additional, Jafar-Nejad, Paymaan, additional, Jain, Sejal V., additional, Jordan, Lori, additional, Kabbouche, Marielle A., additional, Kacperski, Joanne, additional, Kang, Peter B., additional, Kariannis, Matthias A., additional, Kaufmann, Horacio, additional, Kaye, Harper L., additional, Keating, Robert, additional, Kennedy, Colin R., additional, Khakoo, Yasmin, additional, Kirton, Adam, additional, Kissel, John T., additional, Knupp, Kelly G., additional, Korf, Bruce R., additional, Kossoff, Eric H., additional, Kothare, Sanjeev V., additional, Kupfer, Oren, additional, LaFrance, W. Curt, additional, Latal, Beatrice, additional, Leber, Steven M., additional, Lee, Jean-Pyo, additional, Leppik, Ilo E., additional, Lerman-Sagie, Tally, additional, Lerner, Jason T., additional, Leventer, Richard J., additional, Licht, Daniel J., additional, Lichter-Konecki, Uta, additional, Lidar, Zvi, additional, Liem, Djin Gie, additional, Loddenkemper, Tobias, additional, Long, Roger K., additional, Luc, Quyen N., additional, Mackay, Mark, additional, Majnemer, Annette, additional, Makhani, Naila, additional, Malinger, Gustavo, additional, Mandelbaum, David E., additional, Maricich, Stephen M., additional, Maski, Kiran P., additional, Mathur, Mudit, additional, Matthews, Dennis J., additional, McMahon, Kelly, additional, DeMara-Hoth, Megan B., additional, Mendelsohn, Bryce, additional, Mennella, Julie A., additional, Ment, Laura R., additional, Mercuri, Eugenio, additional, Michelson, David J., additional, Mikati, Mohamad A., additional, Mikhail, Fady M., additional, Miller, Steven Paul, additional, Milunsky, Jeff M., additional, Mink, Jonathan W., additional, Mirzaa, Ghayda M., additional, Mitchell, Wendy G., additional, Mohan, Michael A., additional, Mohassel, Payam, additional, Moharir, Mahendranath, additional, Monani, Umrao R., additional, Monje Deisseroth, Michelle, additional, Moodley, Manikum, additional, Mower, Andrew, additional, Moxley, Richard T., additional, Mueller, Sabine, additional, Muotri, Alysson R., additional, Nagamani, Sandesh C.S., additional, Narayanan, Mohan J., additional, Narayanan, Vinodh, additional, Nass, Ruth D., additional, Neul, Jeffrey L., additional, Nevo, Yoram, additional, Ng, Bobby G., additional, Nickels, Katherine C., additional, Nimmo, Graeme A.M., additional, Noetzel, Michael J., additional, Norcliffe-Kaufmann, Lucy, additional, Nordli, Douglas R., additional, Nowak-Göttl, Ulrike, additional, O'Brien, Hope L., additional, Oleszek, Joyce, additional, Oskoui, Maryam, additional, Paciorkowski, Alex R., additional, Packer, Roger J., additional, Packman, Seymour, additional, Palma, Jose-Alberto, additional, Pardo, Andrea C., additional, Parsons, Julie A., additional, Partridge, John Colin, additional, Pastores, Gregory M., additional, Patterson, Marc C., additional, Pearce, William J., additional, Pearl, Phillip L., additional, Penner, Melanie, additional, Percival, Leila, additional, Pereira, Marcia, additional, Pfister, Stefan M., additional, Phillips, John, additional, Plecko, Barbara, additional, Plioplys, Sigita, additional, Poduri, Annapurna, additional, Poisson, Sharon, additional, Pomeroy, Scott L., additional, Poretti, Andrea, additional, Powers, Scott W., additional, Pranzatelli, Michael R., additional, Przekop, Allison, additional, Rabie, Malcolm, additional, Rangasamy, Sampathkumar, additional, Raymond, Gerald V., additional, Reddy, Alyssa T., additional, Rendleman, Rebecca L., additional, Rho, Jong M., additional, Rodan, Lance H., additional, Roddy, Sarah M., additional, Rogers, Elizabeth E., additional, Rosenthal, Stephen M., additional, Rosman, N. Paul, additional, Ross, M. Elizabeth, additional, Rotenberg, Alexander, additional, Rust, Robert S., additional, Sanchez, Cheryl P., additional, Sanchez, Pedro, additional, Sánchez Fernández, Iván, additional, Sands, Tristan T., additional, Sanger, Terence D., additional, Sannagowdara, Kumar, additional, Scheinost, Dustin, additional, Scher, Mark S., additional, Schor, Nina F., additional, Schrauwen, Isabelle, additional, Segal, Michael M., additional, Seinfeld, Syndi, additional, Selcen, Duygu, additional, Seltzer, Laurie E., additional, Semrud-Clikeman, Margaret, additional, Shaw, Dennis W., additional, Shaywitz, Bennett A., additional, Shaywitz, Sally E., additional, Shellhaas, Renée A., additional, Sherr, Elliott H., additional, Sheth, Rita D., additional, Shevell, Michael I., additional, Shinnar, Shlomo, additional, Shofty, Ben, additional, Shu, Stanford K., additional, Shy, Michael E., additional, Silveira Moriyama, Laura, additional, Silvestri, Nicholas J., additional, Sims, Katherine B., additional, Singer, Harvey S., additional, Singhal, Nilika Shah, additional, Smith, Craig M., additional, Smith, Edward, additional, Smith, Stephen A., additional, Snyder, Evan Y., additional, Soul, Janet, additional, Spalink, Christy L., additional, Spencer, Karen A., additional, Stafstrom, Carl E., additional, Steinfeld, Robert, additional, Strober, Jonathan B., additional, Sullivan, Joseph, additional, Swaiman, Kenneth F., additional, Swoboda, Kathryn J., additional, Tate, Elizabeth D., additional, Tatum, William O., additional, Tein, Ingrid, additional, Tekulve, Kristyn, additional, Tenney, Jeffrey R., additional, Thiele, Elizabeth A., additional, Thompson-Stone, Robert, additional, Tochen, Laura, additional, Tormoehlen, Laura M., additional, Tran, Lily, additional, Trauner, Doris A., additional, Turnacioglu, Sinan O., additional, Ullrich, Nicole J., additional, Urion, David K., additional, Van Camp, Guy, additional, Van Hirtum-Das, Michèle, additional, van Karnebeek, Clara D.M., additional, Van Maldergem, Lionel, additional, Vanderver, Adeline, additional, Vitanza, Nicholas A., additional, von Rhein, Michael, additional, von Scheven, Emily, additional, Wagner, Ann, additional, Wainwright, Mark S., additional, Walker, Melissa A., additional, Walkup, John T., additional, Walsh, Laurence, additional, Walters-Sen, Lauren C., additional, Wang, Raymond Y., additional, Warner, Thomas T., additional, Whelan, Harry T., additional, Weinberg, Geoffrey A., additional, Wells, Elizabeth M., additional, Wheless, James W., additional, Wirrell, Elaine C., additional, Wisoff, Jeffrey H., additional, Wolf, Nicole I., additional, Wolfe, Gil I., additional, Wright, F. Virginia, additional, Wycliffe, Nathaniel D., additional, Yang, Michele L., additional, Yuskaitis, Christopher J., additional, Zoghbi, Huda Y., additional, and Zupanc, Mary L., additional

Published
2017
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45. Gross motor change after inpatient rehabilitation for children with acquired brain injury: A 10‐year retrospective review.

Author

Ryan, Jennifer L., Zhou, Chuanlin, Levac, Danielle E., Fehlings, Darcy L., Beal, Deryk S., Hung, Ryan, and Wright, F. Virginia

Subjects
BRAIN injuries, GOAL Attainment Scaling, RETROSPECTIVE studies, SCHOOL children, REHABILITATION
Abstract

Aim: To estimate gross motor change in inpatient school‐aged children with subacute acquired brain injury (ABI), identify factors associated with gross motor change, and describe inpatient physiotherapy focus. Method: This retrospective chart review involved inpatient children (5–18 years) with subacute ABI who had either two Gross Motor Function Measure (GMFM‐88) assessments or one GMFM‐88 with another pre/post gross motor outcome measure. Outcome change scores and Goal Attainment Scaling (GAS) T scores were calculated. Regression analyses examined factors predicting gross motor change. GAS goal areas were analysed to determine physiotherapy focus. Results: Of the 546 charts screened, 266 (118 female) met study criteria. The GMFM‐88 was generally administered first, followed by other measures. GMFM‐88 (n = 202), Community Balance and Mobility Scale (n = 89), and Six‐Minute Walk Test (6MWT) (n = 98) mean change scores were 18.03% (SD 19.34), 17.85% (SD 10.77), and 142.3 m (SD 101.8) respectively. The mean GAS T score was 55.06 (SD 11.50). Lower baseline scores and increased time between assessments were most predictive of greater GMFM‐88 change (r ≥ 0.40). Twenty‐five percent of GAS goals were ambulation‐based. Interpretation: Appropriate outcome measure selection is integral to detecting gross motor change in pediatric inpatient ABI rehabilitation. Mean change score estimates can be used to compare standard inpatient rehabilitation with new treatment approaches. [ABSTRACT FROM AUTHOR]

Published
2023
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46. Effectiveness of parent-mediated participation promoting interventions for children with physical disabilities: A Protocol for a Systematic Review

Author

Testani, Daniela, Shearer, Heather, Munce, Sarah, King, Gillian, and Fehlings, Darcy

Subjects
Rehabilitation and Therapy, children, physical disability, Medicine and Health Sciences, parent-mediated intervention, participation
Abstract

The purpose of this systematic review is to synthesize and critically appraise the literature on the effectiveness of parent-mediated participation promoting interventions in children with physical disabilities.

Published
2022
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48. Comparison of intrathecal baclofen pump insertion and selective dorsal rhizotomy for nonambulatory children with predominantly spastic cerebral palsy

Author

Mansur, Ann, primary, Morgan, Benjamin, additional, Lavigne, Alexandre, additional, Phaneuf-Garand, Nicolas, additional, Diabira, Jocelyne, additional, Yan, Han, additional, Narayanan, Unni G., additional, Fehlings, Darcy, additional, Milo-Manson, Golda, additional, Dalziel, Blythe, additional, Breitbart, Sara, additional, Mercier, Claude, additional, Venne, Dominic, additional, Marois, Pierre, additional, Weil, Alexander G., additional, Raskin, Jeffrey S., additional, Thomas, Sruthi P., additional, and Ibrahim, George M., additional

Published
2022
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