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2. Formulation of Thermo-Sensitive In Situ Gels Loaded with Dual Spectrum Antibiotics of Azithromycin and Ofloxacin.

Author

Alsheikh, Raghad, Haimhoffer, Ádám, Nemes, Dániel, Ujhelyi, Zoltán, Fehér, Pálma, Józsa, Liza, Vasvári, Gábor, Pető, Ágota, Kósa, Dóra, Nagy, Lajos, Horváth, László, Balázs, Bence, and Bácskay, Ildikó

Subjects
OPHTHALMIC drugs, DRUG delivery systems, PATIENT compliance, DRUG absorption, RHEOLOGY
Abstract

In situ gels have been developed as an innovative strategy to prolong corneal residence time and enhance drug absorption compared to traditional eye drops. Our study aimed to formulate an ophthalmic in situ gel with a combination of two thermosensitive poloxamers, P407 and P188, in an optimal ratio not only to increase the time of action but also to increase the solubility of selected antibiotics for the treatment of ophthalmic infections. Two BSC II class substances, Azithromycin and Ofloxacin, with different mechanisms of action, have been incorporated into the in situ gel system after determining their solubility. The antibiotics-loaded in situ gel formulation was evaluated for its clarity, pH, rheological properties, and gel characteristics of gelling time, temperature, and capacity. The formulation demonstrated satisfactory clarity, appropriate pH, effective gelation properties in simulated tear fluid, and suitable rheological characteristics. In addition, APIs release insight has been studied through a dissolution test, and the effectivity against sensitive and resistant bacterial strains has been proved through the antimicrobial study. Therefore, our in situ gel system based on thermosensitive poloxamers, with two hydrophobic antibiotics, AZM and OFX, can be considered a valuable approach for ophthalmic drug delivery with an enhancement of the antibiotics bioavailability through increasing the contact time with the ocular surface and enhancing patient compliance. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Exploring the Correlation between the PASI and DLQI Scores in Psoriasis Treatment with Topical Ointments Containing Rosa × damascena Mill. Extract.

Author

Gavra, Diana Ioana, Kósa, Dóra, Pető, Ágota, Józsa, Liza, Ujhelyi, Zoltán, Fehér, Pálma, Pallag, Annamária, Ghitea, Timea Claudia, Frățilă, Simona, Jurca, Tünde, and Bácskay, Ildikó

Subjects
DAMASK rose, NATUROPATHY, QUALITY of life, PSORIASIS, OINTMENTS
Abstract

Psoriasis is a chronic autoimmune skin condition characterized by red, circumscribed, scaly, and erythematous plaques that can cover large skin areas. While conventional treatments such as topical corticosteroids and systemic medications are commonly prescribed, the interest in natural remedies for psoriasis has grown due to concerns about potential side effects and the desire for alternative treatment options. Rosa × damascena Mill. is rich in bioactive compounds that possess anti-inflammatory, antioxidant, and antimicrobial properties; these properties make Rosa × damascena Mill. a promising candidate for the management of skin disorders such as psoriasis. In our previous studies, we successfully formulated and tested different topical preparations containing Rosa × damascena Mill. In this study, we investigated the correlation between the Psoriasis Area and Severity Index (PASI) and Dermatology Life Quality Index (DLQI) scores in psoriasis treatment using the abovementioned creams containing Rosa × damascena Mill. extract. Several tests were performed to study the correlation between the PASI and DLQI scores in psoriasis patients. Consequently, we were able to observe an improvement in terms of the area, induration, desquamation, and erythema; such an improvement implicitly produces an improvement in patients' quality of life. The PASI and DLQI scores showed significant progress between visits. These results confirm Rosa × damascena Mill. to be a promising candidate for the topical treatment of psoriatic lesions. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Formulation and Investigation of CK2 Inhibitor-Loaded Alginate Microbeads with Different Excipients

Author

Papp, Boglárka, primary, Le Borgne, Marc, additional, Perret, Florent, additional, Marminon, Christelle, additional, Józsa, Liza, additional, Pető, Ágota, additional, Kósa, Dóra, additional, Nagy, Lajos, additional, Kéki, Sándor, additional, Ujhelyi, Zoltán, additional, Pallér, Ádám, additional, Budai, István, additional, Bácskay, Ildikó, additional, and Fehér, Pálma, additional

Published
2023
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15. In Vitro and In Vivo Efficacy of Topical Dosage Forms Containing Self-Nanoemulsifying Drug Delivery System Loaded with Curcumin

Author

Frei, Gréta, primary, Haimhoffer, Ádám, additional, Csapó, Enikő, additional, Bodnár, Krisztina, additional, Vasvári, Gábor, additional, Nemes, Dániel, additional, Lekli, István, additional, Gyöngyösi, Alexandra, additional, Bácskay, Ildikó, additional, Fehér, Pálma, additional, and Józsa, Liza, additional

Published
2023
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16. Determination of the Bioactive Compounds from Echinacea purpurea (L.) Moench Leaves Extracts in Correlation with the Antimicrobial Activity and the In Vitro Wound Healing Potential

Author

Burlou-Nagy, Cristina, primary, Bănică, Florin, additional, Negrean, Rodica Anamaria, additional, Jurca, Tünde, additional, Vicaș, Laura Grațiela, additional, Marian, Eleonora, additional, Bácskay, Ildikó, additional, Kiss, Rita, additional, Fehér, Pálma, additional, Vicaș, Simona Ioana, additional, Miere (Groza), Florina, additional, Memete, Adriana Ramona, additional, and Pallag, Annamaria, additional

Published
2023
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17. Formulation and Evaluation of Insulin-Loaded Sodium-Alginate Microparticles for Oral Administration.

Author

Bácskay, Ildikó, Papp, Boglárka, Pártos, Péter, Budai, István, Pető, Ágota, Fehér, Pálma, Ujhelyi, Zoltán, and Kósa, Dóra

Subjects
ORAL drug administration, SODIUM alginate, INSULIN, BIOPOLYMERS, DRUG delivery systems, NONIONIC surfactants, INSULIN therapy, PEPTIDES
Abstract

The development of oral insulin drug delivery systems is still an ongoing challenge for pharmaceutical technology researchers, as the formulation process has to overcome a number of obstacles due to the adverse characteristics of peptides. The aim of this study was to formulate different sodium-alginate microparticles as a possible method for oral insulin administration. In our previous studies, the method has been successfully optimized using a small model peptide. The incorporation of insulin into alginate carriers containing nonionic surfactants has not been described yet. In order to enhance the absorption of insulin through biological barriers, Labrasol ALF and Labrafil M 2125 CS were selected as permeation-enhancing excipients. They were applied at a concentration of 0.10% (v/v%), along with various combinations of the two, to increase oral bioavailability. Encapsulation efficiency showed sufficient drug incorporation, as it resulted in over 80% in each composition. In vitro dissolution and enzymatic stability test results proved that, as a pH-responsive polymer, alginate bead swelling and drug release occur at higher pH, thus protecting insulin against the harsh environment of the gastrointestinal tract. The remaining insulin content was 66% due to SIF degradation after 120 min. Permeability experiments revealed the impact of permeation enhancers and natural polymers on drug absorption, as they enhanced drug transport significantly through Caco-2 cells in the case of alginate microparticle formulations, as opposed to the control insulin solution. These results suggest that these formulations are able to improve the oral bioavailability of insulin. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Formulation and Evaluation of Transdermal Patches Containing BGP-15.

Author

Bácskay, Ildikó, Hosszú, Zsolt, Budai, István, Ujhelyi, Zoltán, Fehér, Pálma, Kósa, Dóra, Haimhoffer, Ádám, and Pető, Ágota

Subjects
TRANSDERMAL medication, EXPERIMENTAL design, ETHANOL, BIOAVAILABILITY, POLYVINYL alcohol
Abstract

BGP-15 is an active ingredient with many advantages, e.g., beneficial cardiovascular and anti-inflammatory effects. The transdermal administration of BGP-15 has great potential, which has not been investigated yet, despite the fact that it is a non-invasive and safe form of treatment. The aim of our study was to formulate transdermal patches containing BGP-15 and optimize the production with the Box–Behnken design of experiment. The most optimal formulation was further combined with penetration enhancers to improve bioavailability of the active ingredient, and the in vitro drug release and in vitro permeation of BGP-15 from the patches were investigated. FTIR spectra of BGP-15, the formulations and the components were also studied. The most optimal formulation based on the tested parameters was dried for 24 h, with 67% polyvinyl alcohol (PVA) content and low ethanol content. The selected penetration enhancer excipients were not cytotoxic on HaCaT cells. The FTIR measurements and SEM photography proved the compatibility of the active substance and the vehicle; BGP-15 was present in the polymer matrix in dissolved form. The bioavailability of BGP-15 was most significantly enhanced by the combination of Transcutol and Labrasol. The in vitro permeation study confirmed that the formulated patches successfully enabled the transdermal administration of BGP-15. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Development and Evaluation of an FDM Printed Nasal Device for CPZ Solid Nanoparticles

Author

To Quoc, Thinh, primary, Bíró, Krisztina, additional, Pető, Ágota, additional, Kósa, Dóra, additional, Sinka, Dávid, additional, Lekli, István, additional, Kiss-Szikszai, Attila, additional, Budai, István, additional, Béres, Mónika, additional, Vecsernyés, Miklós, additional, Fehér, Pálma, additional, Bácskay, Ildikó, additional, and Ujhelyi, Zoltán, additional

Published
2023
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22. Formulation and Characterization of Mucoadhesive Polymeric Films Containing Extracts of Taraxaci Folium and Matricariae Flos

Author

Neagu, Oana Mihaela, primary, Ghitea, Timea, additional, Marian, Eleonora, additional, Vlase, Laurian, additional, Vlase, Ana-Maria, additional, Ciavoi, Gabriela, additional, Fehér, Pálma, additional, Pallag, Annamária, additional, Bácskay, Ildikó, additional, Nemes, Dániel, additional, Vicaș, Laura Grațiela, additional, Teușdea, Alin, additional, and Jurca, Tünde, additional

Published
2023
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27. Personalized Nasal Protective Devices: Importance and Perspectives.

Author

Quoc, Thinh To, Bácskay, Ildikó, Fehér, Pálma, Pallér, Ádám, Papp, Boglárka, Bíró, Krisztina, and Ujhelyi, Zoltán

Subjects
SAFETY appliances, POLLUTANTS, ENVIRONMENTAL degradation, POLLUTION, SUSTAINABILITY, ELECTRONIC noses, INHALERS, DRUG disposal
Abstract

Nowadays, in addition to diseases caused by environmental pollution, the importance of personalized protection against various infectious agents has become of paramount importance. Besides medicine, several technical and technological studies have been carried out to develop suitable devices. One such revolutionary solution is the use of personalized nasal filters, which allow our body to defend itself more effectively against external environmental damage and pathogens. These filters are small devices that are placed in the nose and specifically filter the inhaled environmental contaminants, allergens, and microorganisms according to individual needs. These devices not only play a key role in maintaining our health but also contribute to environmental protection, reducing the inhalation of pollutants and their harmful impact on the natural environment. Another advantage of personalized filters is that they also provide an opportunity to strengthen our individual immune systems. The use of personalized filters allows medicine to provide optimized protection for everyone, focusing on individual genetic and immunological conditions. The momentum behind the development and research of personalized nasal filters has reached astonishing proportions today. Nowadays, many research groups and medical institutions are working to create new materials, nanotechnologies, and bioinformatics solutions in order to create even more effective personalized nasal filters that can also be shaped easily and safely. Considering the needs of the users is at least as important during development as the efficiency of the device. These two properties together determine the success of the product. Industry research focuses not only on improving the efficiency of devices, but also on making them more responsive to user needs, comfort, and portability. Based on all this, it can be concluded that personalized nasal filters can be a promising and innovative solution for protection against environmental pollutants and pathogens. Through a commitment to the research and development of technology, the long-term impact of such devices on our health and the environment can be significant, contributing to improving people's quality of life and creating a sustainable future. With unique solutions and continuous research, we give hope that in the future, despite the environmental challenges, we can enjoy the protection of our health with even more efficient and sophisticated devices. [ABSTRACT FROM AUTHOR]

Published
2023
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29. Enhanced Antioxidant and Anti-Inflammatory Effects of Self-Nano and Microemulsifying Drug Delivery Systems Containing Curcumin

Author

Józsa, Liza, primary, Vasvári, Gábor, additional, Sinka, Dávid, additional, Nemes, Dániel, additional, Ujhelyi, Zoltan, additional, Vecsernyés, Miklós, additional, Váradi, Judit, additional, Fenyvesi, Ferenc, additional, Lekli, István, additional, Gyöngyösi, Alexandra, additional, Bácskay, Ildikó, additional, and Fehér, Pálma, additional

Published
2022
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30. In Vitro and Human Pilot Studies of Different Topical Formulations Containing Rosa Species for the Treatment of Psoriasis

Author

Gavra, Diana Ioana, primary, Endres, Laura, additional, Pető, Ágota, additional, Józsa, Liza, additional, Fehér, Pálma, additional, Ujhelyi, Zoltán, additional, Pallag, Annamária, additional, Marian, Eleonora, additional, Vicas, Laura Gratiela, additional, Ghitea, Timea Claudia, additional, Muresan, Mariana, additional, Bácskay, Ildikó, additional, and Jurca, Tünde, additional

Published
2022
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36. Formulation, Characterization and Permeability Studies of Fenugreek (Trigonella foenum-graecum) Containing Self-Emulsifying Drug Delivery System (SEDDS)

Author

Sinka, Dávid, primary, Doma, Enikő, additional, Szendi, Nóra, additional, Páll, Jázmin, additional, Kósa, Dóra, additional, Pető, Ágota, additional, Fehér, Pálma, additional, Ujhelyi, Zoltán, additional, Fenyvesi, Ferenc, additional, Váradi, Judit, additional, Vecsernyés, Miklós, additional, Szűcs, Zsolt, additional, Gonda, Sándor, additional, Cziáky, Zoltán, additional, Kiss-Szikszai, Attila, additional, Vasas, Gábor, additional, and Bácskay, Ildikó, additional

Published
2022
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37. Topical Dosage Formulation of Lyophilized Philadelphus coronarius L. Leaf and Flower: Antimicrobial, Antioxidant and Anti-Inflammatory Assessment of the Plant

Author

Pető, Ágota, primary, Kósa, Dóra, additional, Haimhoffer, Ádám, additional, Nemes, Dániel, additional, Fehér, Pálma, additional, Ujhelyi, Zoltán, additional, Vecsernyés, Miklós, additional, Váradi, Judit, additional, Fenyvesi, Ferenc, additional, Frum, Adina, additional, Gligor, Felicia Gabriela, additional, Vicaș, Laura Grațiela, additional, Marian, Eleonora, additional, Jurca, Tunde, additional, Pallag, Annamaria, additional, Muresan, Mariana Eugenia, additional, Tóth, Zoltán, additional, and Bácskay, Ildikó, additional

Published
2022
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38. Investigation of the Role and Effectiveness of Chitosan Coating on Probiotic Microcapsules

Author

Erdélyi, Lóránd, primary, Fenyvesi, Ferenc, additional, Gál, Bernadett, additional, Haimhoffer, Ádám, additional, Vasvári, Gábor, additional, Budai, István, additional, Remenyik, Judit, additional, Bereczki, Ilona, additional, Fehér, Pálma, additional, Ujhelyi, Zoltán, additional, Bácskay, Ildikó, additional, Vecsernyés, Miklós, additional, Kovács, Renátó, additional, and Váradi, Judit, additional

Published
2022
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42. Nicotinic Amidoxime Derivate BGP-15, Topical Dosage Formulation and Anti-Inflammatory Effect

Author

Pető, Ágota, Kósa, Dóra, Haimhoffer, Ádám, Fehér, Pálma, Ujhelyi, Zoltán, Sinka, Dávid, Fenyvesi, Ferenc, Váradi, Judit, Vecsernyés, Miklós, Gyöngyösi, Alexandra, Lekli, István, Szentesi, Péter, Marton, Annamária, Gombos, Imre, Dukic, Barbara, Vígh, László, and Bácskay, Ildikó

Subjects
RS1-441, antioxidant, PARP inhibitor, Pharmacy and materia medica, anti-inflammatory drug, ointments, drug delivery, dosage formulation, BGP-15, nicotinic amidoxime derivate, Article, surfactants
Abstract

BGP-15 is a Hungarian-developed drug candidate with numerous beneficial effects. Its potential anti-inflammatory effect is a common assumption, but it has not been investigated in topical formulations yet. The aim of our study was to formulate 10% BGP-15 creams with different penetration enhancers to ensure good drug delivery, improve bioavailability of the drug and investigate the potential anti-inflammatory effect of BGP-15 creams in vivo. Since the exact mechanism of the effect is still unknown, the antioxidant effect (tested with UVB radiation) and the ability of BGP-15 to decrease macrophage activation were evaluated. Biocompatibility investigations were carried out on HaCaT cells to make sure that the formulations and the selected excipients can be safely used. Dosage form studies were also completed with texture analysis and in vitro release with Franz diffusion chamber apparatus. Our results show that the ointments were able to reduce the extent of local inflammation in mice, but the exact mechanism of the effect remains unknown since BGP-15 did not show any antioxidant effect, nor was it able to decrease LPS-induced macrophage activation. Our results support the hypothesis that BGP-15 has a potential anti-inflammatory effect, even if it is topically applied, but the mechanism of the effect remains unclear and requires further pharmacological studies.

Published
2021

47. Pharmacological Overview of the Drug Candidate BGP-15

Author

Pető, Ágota, primary, Kósa, Dóra, additional, Fehér, Pálma, additional, Jhelyi, Zoltán, additional, Sinka, Dávid, additional, Vecsernyés, Miklós, additional, Szilvássy, Zoltán, additional, Juhász, Béla, additional, Csanádi, Zoltán, additional, and Bácskay, Ildikó, additional

Published
2021
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