6 results on '"Federico Menetti"'
Search Results
2. Intra-arterial therapy as a rescue strategy after clinically failed intravenous thrombolysis may increase the likelihood of a good outcome in patients with severe ischaemic stroke. A retrospective two centre study
- Author
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Andrea Zini, Paolo Carpeggiani, Tommy Andersson, Federico Menetti, Stefano Vallone, and Luca Verganti
- Subjects
Adult ,Male ,Reoperation ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Tissue plasminogen activator ,Brain Ischemia ,Brain ischemia ,Young Adult ,Fibrinolytic Agents ,Ischaemic stroke ,medicine ,Humans ,Thrombolytic Therapy ,Treatment Failure ,Young adult ,Stroke ,Aged ,Retrospective Studies ,Sweden ,Cerebral Revascularization ,business.industry ,Retrospective cohort study ,Thrombolysis ,Original Articles ,Cerebral Arteries ,Middle Aged ,medicine.disease ,Surgery ,Radiography ,Treatment Outcome ,Italy ,Anesthesia ,Tissue Plasminogen Activator ,Female ,business ,Fibrinolytic agent ,medicine.drug - Abstract
The purpose of this study was to evaluate the efficacy and safety of intra-arterial therapy as a rescue strategy after clinically failed intravenous thrombolysis (IVT) in acute ischaemic stroke patients. We conducted a retrospective analysis of consecutive acute ischaemic stroke patients treated with rescue therapy. The results from this study group were compared with those obtained from a control group consisting of 260 consecutive patients treated with IVT alone. The study group consisted of 52 patients with a mean age of 63 years and a median NIHSS score at admission of 17. Recanalization was achieved in 92% with a symptomatic haemorrhage rate of 9.6%. Rescue patients admitted with a severe stroke (NIHSS score >12) had a significantly better outcome at 90 days compared to patients with the same score but treated with IVT alone. No difference was seen for patients with a lower score at admission. This study indicates that rescue therapy may increase the proportion of patients with independent outcome if presenting with a severe stroke (NIHSS score >12) without increasing the rate of symptomatic haemorrhage.
- Published
- 2013
3. A classification tree approach for pituitary adenomas
- Author
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Marco Faustini-Fustini, Maria Pia Foschini, Andrea Sisto, Raffaele Agati, Anna Farnedi, Patrizia Agati, Giorgio Frank, Alberto Righi, Diego Mazzatenta, Gianluca Marucci, Federico Menetti, Righi A, Agati P, Sisto A, Frank G, Faustini-Fustini M, Agati R, Mazzatenta D, Farnedi A, Menetti F, Marucci G, and Foschini MP.
- Subjects
Oncology ,Adult ,Male ,medicine.medical_specialty ,Pathology ,Mitotic index ,Pituitary neoplasm ,Sensitivity and Specificity ,CLASSIFICATION ,PITUITARY ADENOMA ,Pathology and Forensic Medicine ,Correlation ,Pituitary adenoma ,Internal medicine ,medicine ,Biomarkers, Tumor ,Cutoff ,Humans ,Pituitary Neoplasms ,KI67 ,P53 ,biology ,Receiver operating characteristic ,business.industry ,Middle Aged ,medicine.disease ,Prognosis ,Prolactin ,Ki-67 Antigen ,ROC Curve ,Ki-67 ,Area Under Curve ,biology.protein ,Disease Progression ,Female ,Tumor Suppressor Protein p53 ,business - Abstract
It is difficult to evaluate the recurrence and progression potential of pituitary adenomas at presentation. The World Health Organization classification of endocrine tumors suggests that invasion of the surrounding structures, size at presentation, an elevated mitotic index, a Ki-67 labeling index higher than 3%, and extensive p53 expression are indicators of aggressive behavior. Nevertheless, Ki-67 and p53 labeling index evaluation is subject to interobserver variability, and their cutoff values are controversial. In the present study, the prognostic value of Ki-67 and p53 protein labeling indices and their correlation with clinical and radiologic parameters were evaluated using digital image analysis in a series of 166 pituitary adenomas in patients having undergone a follow-up of at least 6 years to evaluate the impact on the recurrence and progression potential of pituitary adenomas. The data were analyzed using the receiver operating characteristic curve and classification and regression tree analysis. The results showed that, in the unstratified data set, the commonly used threshold of the Ki-67 index of 3% has a high specificity (89.5%) but a low sensitivity (53.8%). Unsatisfactory performance results were obtained by performing receiver operating characteristic curve analysis on the p53 labeling index. On the contrary, the classification and regression tree analysis-derived tree demonstrated that each pituitary adenoma subtype has specific prognostic factors. Specifically, the Ki-67 labeling index is a useful prognostic factor in nonfunctioning, adrenocorticotropin, and prolactin adenomas, but with different thresholds. In conclusion, our study emphasizes that the term pituitary adenomas includes different types of tumors, each one having specific prognostic factors.
- Published
- 2011
4. Amyloidoma Involving the Orbit, Meckel's Cave and Infratemporal Fossa: 3T MRI Findings
- Author
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Raffaele Agati, Fabrizio Salvi, Andrea Ambrosini-Spaltro, Federico Menetti, Marco Leonardi, and I. Bartolomei
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Amyloidoma ,business.industry ,Infratemporal fossa ,General Medicine ,Foramen ovale (skull) ,Anatomy ,Cerebellopontine angle ,Lesion ,medicine.anatomical_structure ,Cavernous sinus ,Medicine ,Radiology, Nuclear Medicine and imaging ,Neurology (clinical) ,medicine.symptom ,business ,Jugular foramen ,Orbit (anatomy) - Abstract
Amyloidoma is a rare lesion characterized by tissue deposition of an abnormal fibrillary protein (amyloid). It is the focal and localized counterpart of systemic amyloidosis, where the deposition of amyloid diffusely involves several organs. The few literature reports of intracranial amyloidomas include lesions involving the pituitary gland, orbit, cerebral hemispheres, temporal bone, cerebellopontine angle and jugular foramen. We describe the case of a 27-year-old woman presenting with painless slowly progressive proptosis of the right eye. The patient underwent a contrast-enhanced CT study of the head, followed by 3T MRI which disclosed a homogeneous mass in the right Meckel's cave and cavernous sinus, extending through an enlarged foramen ovale to the infratemporal fossa. The right optic nerve and ocular muscles were enlarged and infiltrated along with the retrobulbar fat by contrast-enhancing tissue. Thin contrast-enhanced MRI scans through the area of interest showed the mass to extend posterior to the gasserian ganglion, involving the cerebellopontine angle cistern, where the intracisternal parts of the III, V, and VI nerves bilaterally appeared enlarged and showed perineural enhancement. The lesion closely mimicked a malignant tumor with perineural tumor infiltration, so we performed fine needle biopsy of the portion of the lesion near the right foramen ovale under fluoroscopic guidance. Histopathology revealed that the lesion was an amyloidoma. Further clinical and blood examinations, serum chemistry, followed by biopsy of the periumbilical fat showed no signs of systemic amyloidosis or an underlying inflammatory or neoplastic disorder. No further treatment was instituted, follow-up MRI six months later showed no enlargement of the mass.
- Published
- 2009
5. Age-dependent decreases of calcium, phosphorus, sulfur, and zinc in the cardiac valves of monkeys
- Author
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Pasuk Mahakkanukrauh, Cho Azuma, Takao Oishi, Hiroyasu Satoh, Setsuko Tohno, Yoshiyuki Tohno, Takeshi Minami, Federico Menetti, Yumi Moriwake, and Motoharu Hayashi
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medicine.medical_specialty ,Aging ,Endocrinology, Diabetes and Metabolism ,Clinical Biochemistry ,chemistry.chemical_element ,Age dependent ,Zinc ,Calcium ,Biochemistry ,Inorganic Chemistry ,Mitral valve ,Internal medicine ,Cardiac valve ,medicine ,Animals ,Calcium phosphorus ,Optical emission spectrometry ,Chemistry ,Spectrophotometry, Atomic ,Biochemistry (medical) ,Phosphorus ,General Medicine ,medicine.disease ,Heart Valves ,Macaca mulatta ,medicine.anatomical_structure ,Endocrinology ,cardiovascular system ,Cardiology ,Macaca ,Sulfur ,Calcification - Abstract
To elucidate compositional changes of the cardiac valves in monkey with aging, the authors investigated age-related changes of elements in the four cardiac valves of rhesus and Japanese monkeys and the relationships among elements by inductively coupled plasma-atomic emission spectrometry (ICP-AES). The four cardiac valves of the aortic, pulmonary, mitral, and tricuspid valves were resected from 19 rhesus and 11 Japanese monkeys, ranging in age from 10 d to 33 yr. The element contents were determined by ICP-AES. It was found that the Ca, P, S, and Zn contents were high in the four cardiac valves of the monkeys below 1 yr and thereafter decreased significantly with aging, except for Ca in the mitral valve, for which no significant correlation was found between age and Ca content. The Ca and P contents did not increase in the four cardiac valves at old age. This result revealed that calcification scarcely occurred in the four cardiac valves at old age. With regard to the relationships among elements, it was found that there were significant direct correlations among the Ca, P, S, and Zn contents in all of the four cardiac valves of the monkeys, with two exceptions between P and Zn contents in both the aortic and pulmonary valves. Therefore, as Ca decreased in the four cardiac valves, P, S, and Zn decreased simultaneously in the same cardiac valves.
- Published
- 2004
6. Age-Dependent Decreases of Calcium, Phosphorus, Sulfur, and Zinc in the Cardiac Valves of Monkeys.
- Author
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Federico Menetti, Setsuko Tohno, Yoshiyuki Tohno, Cho Azuma, Yumi Moriwake, Hiroyasu Satoh, Takeshi Minami, Pasuk Mahakkanukrauh, Takao Oishi, and Motoharu Hayashi
- Abstract
To elucidate compositional changes of the cardiac valves in monkey with aging, the authors investigated age-related changes of elements in the four cardiac valves of rhesus and Japanese monkeys and the relationships among elements by inductively coupled plasma–atomic emission spectrometry (ICP-AES). The four cardiac valves of the aortic, pulmonary, mitral, and tricuspid valves were resected from 19 rhesus and 11 Japanese monkeys, ranging in age from 10 d to 33 yr. The element contents were determined by ICP-AES. It was found that the Ca, P, S, and Zn contents were high in the four cardiac valves of the monkeys below 1 yr and thereafter decreased significantly with aging, except for Ca in the mitral valve, for which no significant correlation was found between age and Ca content. The Ca and P contents did not increase in the four cardiac valves at old age. This result revealed that calcification scarcely occurred in the four cardiac valves at old age. With regard to the relationships among elements, it was found that there were significant direct correlations among the Ca, P, S, and Zn contents in all of the four cardiac valves of the monkeys, with two exceptions between P and Zn contents in both the aortic and pulmonary valves. Therefore, as Ca decreased in the four cardiac valves, P, S, and Zn decreased simultaneously in the same cardiac valves. [ABSTRACT FROM AUTHOR]
- Published
- 2005
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