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3. Pre-existent NRTI and NNRTI resistance impacts on maintenance of virological suppression in HIV-1-infected patients who switch to a tenofovir/emtricitabine/rilpivirine single-tablet regimen

Author

Armenia, D., Di Carlo, D., Calcagno, A., Vendemiati, G., Forbici, F., Bertoli, A., Berno, G., Carta, S., Continenza, F., Fedele, V., Bellagamba, R., Cicalini, S., Ammassari, A., Libertone, R., Zaccarelli, M., Ghisetti, V., Andreoni, M., Ceccherini-Silberstein, F., Bonora, S., Di Perri, G., Antinori, A., Perno, C. F., and Santoro, M. M.

Published
2017
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4. HIV-1 integrase genotyping is reliable and reproducible for routine clinical detection of integrase resistance mutations even in patients with low-level viraemia

Author

Armenia, D., Fabeni, L., Alteri, C., Di Pinto, D., Di Carlo, D., Bertoli, A., Gori, C., Carta, S., Fedele, V., Forbici, F., DʼArrigo, R., Svicher, V., Berno, G., Pizzi, D., Nicastri, E., Sarmati, L., Pinnetti, C., Ammassari, A., DʼOffizi, G., Latini, A., Andreoni, M., Antinori, A., Ceccherini-Silberstein, F., Perno, C. F., and Santoro, M. M.

Published
2015
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14. Cerebrospinal Fluid Abacavir Concentrations in HIV-positive Patients Following Once-daily Administration

Author

Calcagno, A., Pinnetti, C., De Nicolò, A., Scarvaglieri, E., Gisslen, M., Tempestilli, M., D'Avolio, A., Fedele, V., Di Perri, G., Antinori, A., and Bonora, S.

Subjects
Adult, Male, Time Factors, Anti-HIV Agents, abacavir, protease inhibitors, virus diseases, HIV Infections, Middle Aged, central nervous system, Dideoxynucleosides, Drug Administration Schedule, cerebrospinal fluid, age, pharmacokinetics, Treatment Outcome, Short Reports, Italy, immune system diseases, Tandem Mass Spectrometry, Humans, Female, Drug Monitoring, Chromatography, High Pressure Liquid
Abstract

Abacavir is a widely used nucleotide reverse transcriptase inhibitor, for which cerebrospinal fluid (CSF) exposure has been previously assessed in twice‐daily recipients. We studied abacavir CSF concentrations in 61 and nine HIV‐positive patients taking abacavir once daily and twice daily, respectively. Patients on once‐daily abacavir had higher plasma and CSF concentrations (96 vs. 22 ng ml(−1), P = 0.038 and 123 vs. 49 ng ml(−1), P = 0.038) but similar CSF‐to‐plasma ratios (0.8 vs. 0.5, P = 0.500). CSF abacavir concentrations were adequate in patients receiving once‐daily treatment.

Published
2018

16. Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation

Author

Meier, JC, Tallant, C, Fedorov, O, Witwicka, H, Hwang, SY, van Stiphout, RG, Lambert, JP, Rogers, C, Yapp, C, Gerstenberger, BS, Fedele, V, Savitsky, P, Heidenreich, D, Daniels, DL, Owen, DR, Fish, PV, Igoe, NM, Bayle, ED, Haendler, B, Oppermann, UCT, Buffa, F, Brennan, PE, Müller, S, Gingras, AC, Odgren, PR, Birnbaum, MJ, and Knapp, S

Subjects
Models, Molecular, Protein Conformation, Stem Cells, Protein Array Analysis, Computational Biology, Osteoclasts, Bone Marrow Cells, Cell Differentiation, Articles, Protein Domains, Multigene Family, Animals, Humans, Carrier Proteins
Abstract

Histone acetyltransferases of the MYST family are recruited to chromatin by BRPF scaffolding proteins. We explored functional consequences and the therapeutic potential of inhibitors targeting acetyl-lysine dependent protein interaction domains (bromodomains) present in BRPF1-3 in bone maintenance. We report three potent and selective inhibitors: one (PFI-4) with high selectivity for the BRPF1B isoform and two pan-BRPF bromodomain inhibitors (OF-1, NI-57). The developed inhibitors displaced BRPF bromodomains from chromatin and did not inhibit cell growth and proliferation. Intriguingly, the inhibitors impaired RANKL-induced differentiation of primary murine bone marrow cells and human primary monocytes into bone resorbing osteoclasts by specifically repressing transcriptional programs required for osteoclastogenesis. The data suggest a key role of BRPF in regulating gene expression during osteoclastogenesis, and the excellent druggability of these bromodomains may lead to new treatment strategies for patients suffering from bone loss or osteolytic malignant bone lesions.

Published
2017

21. Pre-existent NRTI and NNRTI resistance impacts on maintenance of virological suppression in HIV-1-infected patients who switch to a tenofovir/emtricitabine/rilpivirine single-tablet regimen

Author

Armenia, D., primary, Di Carlo, D., additional, Calcagno, A., additional, Vendemiati, G., additional, Forbici, F., additional, Bertoli, A., additional, Berno, G., additional, Carta, S., additional, Continenza, F., additional, Fedele, V., additional, Bellagamba, R., additional, Cicalini, S., additional, Ammassari, A., additional, Libertone, R., additional, Zaccarelli, M., additional, Ghisetti, V., additional, Andreoni, M., additional, Ceccherini-Silberstein, F., additional, Bonora, S., additional, Di Perri, G., additional, Antinori, A., additional, Perno, C. F., additional, and Santoro, M. M., additional

Published
2016
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22. La polis del futuro

Author

Aro, J., Heiskala, R., Camorrino, A., Cerroni, A., Giuffredi, R., Facioni, C., Fedele, V., Patalano, R., Paura, R., and Verdi, Laura

Subjects
urban regeneration, ecological limitations, Innovation, social responsibility, ethical and political action, urban regeneration, retraining, reuse, contraction, ecological limitations, social responsibility, contraction, ethical and political action, retraining, Innovation, reuse
Published
2015

23. Contenimento dello sprawl , governance inclusiva e pratiche innovative nella città di Portland -Oregon.

Author

Agustoni, A, Barazzetti, D, Beretta, I, Borelli, G, Borrelli, N, Campennì, A, Campolongo, F, Carrà, C, Caruso, FS, Catalano, G, Ciccone, S, Corbisiero, F, Coscarello, M, Cosentino, D, De Falco, CC, Debernardi, B, Diamantini, D, Dionesalvi, C, Elia, A, Ercole, E, Fama, M, Fedele, V, Fraire, M, Garofalo, S, Giunta, I, Granitto, A, Groe, L, Maltese, F, Marino, S, Musolino, E, Patrucco, D, Punzi, C, Roccisano, F, Romita, T, Ruspini, E, Salerno, G, Sciarrone, C, Scotti, I, Sessa, F, Spagnuolo, S, Stasi, S, Sturniolo, L, Trezza, D, Vignola, M, Vingelli, G, Vitale, A, BORRELLI, NUNZIA, DIAMANTINI, DAVIDE, Agustoni, A, Barazzetti, D, Beretta, I, Borelli, G, Borrelli, N, Campennì, A, Campolongo, F, Carrà, C, Caruso, FS, Catalano, G, Ciccone, S, Corbisiero, F, Coscarello, M, Cosentino, D, De Falco, CC, Debernardi, B, Diamantini, D, Dionesalvi, C, Elia, A, Ercole, E, Fama, M, Fedele, V, Fraire, M, Garofalo, S, Giunta, I, Granitto, A, Groe, L, Maltese, F, Marino, S, Musolino, E, Patrucco, D, Punzi, C, Roccisano, F, Romita, T, Ruspini, E, Salerno, G, Sciarrone, C, Scotti, I, Sessa, F, Spagnuolo, S, Stasi, S, Sturniolo, L, Trezza, D, Vignola, M, Vingelli, G, Vitale, A, BORRELLI, NUNZIA, and DIAMANTINI, DAVIDE

Published
2016

24. Identification and characterization of c-Jun-N-terminal phosphorylation as an epigenetic regulator of highly methylated gene promoter regions in glioblastoma multiforme

Author

Heiland, DH, Ferrarese, R, Dai, F, Claus, R, Masilamani, A, Unterkircher, T, Fedele, V, Bug, E, Carro, MS, and Weyerbrock, A

Subjects
glioblastoma multiforme, ddc: 610, epigenetics, methylation, 610 Medical sciences, Medicine
Abstract

Objective: High-grade gliomas (HGG) are the most common brain tumors with an average survival of 14 months. A large number of highly methylated gene loci (G-CIMP) are associated with the proneural subgroup and better clinical outcome. Our aim was to identify and characterize putative transcription factors[for full text, please go to the a.m. URL], 65. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Published
2014
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25. Gastro-intestinal strongyle faecal egg count and worm burden in goats

Author

CRINGOLI, GIUSEPPE, VENEZIANO, VINCENZO, RINALDI, LAURA, Santaniello, Mirella, Pennacchio, Saverio, Morgoglione, Maria Elena, Fedele, V., Cringoli, Giuseppe, Veneziano, Vincenzo, Rinaldi, Laura, Santaniello, Mirella, Pennacchio, Saverio, Morgoglione, Maria Elena, and Fedele, V.

Published
2008

26. Trattamenti strategici per il controllo delle strongilosi gastrointestinali degli ovini: efficacia antiparassitaria ed efficacia produttiva

Author

VENEZIANO, VINCENZO, RINALDI, LAURA, CRINGOLI, GIUSEPPE, Mezzino L., Morgoglione M. E., Santaniello A., Rufrano D., Fedele V., Manfredi MT, Veneziano, Vincenzo, Rinaldi, Laura, Mezzino, L., Morgoglione, M. E., Santaniello, A., Rufrano, D., Fedele, V., and Cringoli, Giuseppe

Subjects
ovini, Strongili gastrointestinali, trattamenti antielmintici
Published
2008

28. Economic efficacy of anthelmintic treatments in dairy sheep naturally infected by gastrointestinal strongyles

Author

Cringoli, G., Vincenzo VENEZIANO, Pennacchio, S., Mezzino, L., Santaniello, M., Schioppi, M., Fedele, V., Rinaldi, L., Cringoli, Giuseppe, Veneziano, Vincenzo, Pennacchio, S., Mezzino, L., Santaniello, M., Schioppi, M., Fedele, V., and Rinaldi, Laura

Subjects
Anthelmintics, Sheep, Sheep Diseases, Comorbidity, Puerperal Disorders, Guanidines, Dairying, Italy, Pregnancy, Animals, Drug Evaluation, Lactation, Female, Macrolides, Helminthiasis, Animal, Intestinal Diseases, Parasitic, Pregnancy Complications, Infectious, Parasite Egg Count, Strongylida Infections
Abstract

The aim of the present paper was to assess benefit of strategic anthelmintic treatments on milk production in six commercial dairy sheep farms, located in southern Italy, whose animals were naturally infected with gastrointestinal strongyles. On each farm, two similar groups were formed, one untreated control group and one treated group. In all the treated groups, the strategic anthelmintic schemes were based on: (i) only one treatment with moxidectin in the periparturient period (February, Farm No. 6), or; (ii) two treatments, i.e. the first with moxidectin performed in the periparturient period (February, Farms Nos. 1, 2, 3 and 4) or in the postparturient period (April, Farm No. 5), and the second with netobimin at the mid/end of lactation (June, Farms Nos. 1, 2, 3, 4 and 5). Faecal egg count reduction (FECR) tests were performed on each farm in order to asses the anthelmintic efficacy of the drugs used. In addition, milk yield measurements for each animal fortnightly in each farm for the lactation period were performed. In terms of FECR, both moxidectin and netobimin were effective in all the 6 studied farms. Regarding milk production, overall in the 6 study farms the mean daily milk productions of the treated groups were higher than those of the control group. However, there were important differences between the 6 farms, i.e. the increase of milk production in the treated groups versus the control groups was as follows: +18.9% (Farm 1), +30.4% (Farm 2), +4.0% (Farm 3), +37.0% (Farm 4), +5.5% (Farm 5) and +40.8% (Farm 6). The results of the study showed that the economic efficacy of an anthelmintic treatment is not a cause-effect issue, but is a multifactorial issue which depends upon the quali-quantitative parasitological status of the animals, the pathogenesis of the species of parasites, the virulence of the strains of parasites, the local epidemiology, the timing of treatment, the breed of animal in terms of genetics and production types, nutrient supply.

Published
2007

38. Activation of mitochondrial pathway is the central event of the apoptosis in the human placenta during pregnancy

Author

MASTROGIACOMO A, COBELLIS, Luigi, DE FALCO M, LEONE S, GIRALDI D, FEDELE V, LAFORGIA V, DE LUCA B., DE LUCA, Antonio, A., Mastrogiacomo, L., Cobelli, DE FALCO, Maria, S., Leone, D., Giraldi, V., Fedele, A., De Luca, Laforgia, Vincenza, B., De Luca, Mastrogiacomo, A, Cobellis, Luigi, DE FALCO, M, Leone, S, Giraldi, D, Fedele, V, DE LUCA, Antonio, Laforgia, V, and DE LUCA, B.

Published
2003

42. Vasoactive intestinal peptide stimulation modulates the expression of Bcl-2 family members in the adrenal gland of the lizard Podarcis sicula

Author

DE FALCO M, LAFORGIA V, FEDELE V, DE LUCA L, COTTONE G, DE FALCO G, DE LUCA, Antonio, DE FALCO, Maria, Laforgia, Vincenza, V., Fedele, L., De Luca, G., Cottone, G., De Falco, A., De Luca, DE FALCO, M, Laforgia, V, Fedele, V, DE LUCA, L, Cottone, G, DE FALCO, G, and DE LUCA, Antonio

Subjects
Male, Proto-Oncogene Proteins c-bcl-2, Proto-Oncogene Proteins, Adrenal Glands, In Situ Nick-End Labeling, Animals, Apoptosis, Female, Lizards, Immunohistochemistry, Injections, Intraperitoneal, Vasoactive Intestinal Peptide, bcl-2-Associated X Protein
Abstract

The adrenal gland of the lizard Podarcis sicula is formed by a dorsal ribbon of chromaffin cells, generally defined as medullary tissue, arranged along a central part of steroidogenic cells considered as cortical tissue. These two tissues produce catecholamines and steroids as part of the hypothalamo-hypophyseal-adrenal gland axis. Recent studies have demonstrated that Podarcis sicula adrenal gland is not only under hypothalamo-hypophyseal axis control but that several peptides may influence the physiological activity of the gland; among these, vasoactive intestinal peptide is able to enhance strongly both catecholamine and steroid hormone production. The aim of the present study was to verify whether vasoactive intestinal peptide administration could become deleterious. For this reason, we monitored the pattern of expression of two members of the Bcl-2 family, Bcl-2 and Bax, in control and vasoactive intestinal peptide treated specimens. Furthermore, we also tested if peptide treatment induces apoptosis by TUNEL assay.

Published
2001

44. Effetti dell'attività fisica su performance cognitivi e tono dell'umore in una popolazione di ultra settantenni

Author

Pirrone, S, Schifilliti, C, Minicuccio, G, Fedele, V, Cucinotta, L, Salerno, A, Luca, Salvatore, Maugeri, D, and Leotta, C.

Subjects
elderlypeople, affective tone, Physical activity, elderlypeople, affective tone, cognitive tone, attività fisica, anziani, tono cognitivo, tono affettivo, attività fisica, tono affettivo, Physical activity, cognitive tone, tono cognitivo, anziani
Published
2010

47. Dégradabilité ruminale de monoterpènes présents dans le régime de printemps de la chèvre laitière dans le Basilicate (italie)

Author

Malecky, Mostafa, Fedele, V., Broudiscou, Laurent, Physiologie de la Nutrition et Alimentation (PNA), Institut National Agronomique Paris-Grignon (INA P-G)-Institut National de la Recherche Agronomique (INRA), Instituto sperimentale per la zootecnia, Partenaires INRAE, Institut National de la Recherche Agronomique (INRA)-Institut National Agronomique Paris-Grignon (INA P-G), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], [INFO] Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2006

50. Effects of grass-based diets on the content of micronutrients and fatty acids in bovine and caprine dairy products

Author

Martin, B., Fedele, V., Ferlay, Anne, Grolier, Pascal, Rock, Edmond, Gruffat, Dominique, Chilliard, Yves, Unité de Recherches sur les Herbivores (URH), Institut National de la Recherche Agronomique (INRA), Unité de recherche Maladies Métaboliques et Micronutriments (U3M), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], [INFO] Computer Science [cs], VALEUR NUTRITIONNELLE, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2004

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